arXiv:2610.38245v1 Announce Type: new Abstract: Retrosynthesis planning seeks synthesis routes from purchasable starting materials to a target molecule. Search over predicted reactions can connect a target to available materials, yet an infeasible reaction can invalidate the resulting route. Evaluating route quality only after search has finished cannot correct errors made during search. We introduce Verification-Guided Reflow (VGR), incorporating reaction verification as a decision action in AND/OR search. Verification results are represented as binary verdicts; queries are scheduled from the search structure, and acquired verdicts exclude reactions or adjust search priorities. We define verified solvability as the fraction of targets for which a complete route accepted stepwise by the verifier is found. On Retro190, feeding verification results into search increases verified solvability from 51.1% to 62.6% relative to route evaluation without feedback. Further controlled experiments show that earlier verification and immediate prioritization of accepted reactions each improve route discovery, yet combining them performs worse than either change alone. We therefore propose early pruning and delayed guidance: rejected reactions are pruned immediately, while accepted reactions gain search priority when processed as part of a complete candidate route. In a separate comparison with the verification scheduling rule fixed, this strategy increases verified solvability from 61.1% with immediate guidance to 71.1%, using fewer proposal calls and unique verifier queries.
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