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Scientists reveal how cosignaling receptors dually regulate T cell activation via phase separation

Phys.org · WORLD · Science · 11/4/2026, 7:20:01 PM

Previous studies have shown that upon antigen stimulation, the T cell receptor (TCR) undergoes phase separation with the kinase Lck to mediate rapid T cell activation. However, the manner in which costimulating receptors regulate this process has remained unclear.

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