,,ii  #aai? ,,congress  #a/ ,session    
,s4 #hed  ,,9 ,,! ,,s5ate ,,( ,,!       
,,unit$ ,,/ates  ,m>* #e1 #bjbe ,mr4    
,paul 7= himself & ,mr4 ,pet]s7         
introduc$ ! foll[+ bill2 :i* 0 read     
twice & ref]r$ to ! ,committee on       
,homel& ,security & ,gov]nm5tal ,affairs
  ,a ,,bill  ,to am5d title #ca1 ,unit$ 
,/ates ,code1 to e/abli% ! ,life        
,sci5ces ,rese>* ,security ,bo>d1 & =   
o!r purposes4  #a4 ,%ort title ,?is ,act
 may be cit$ z ! ,risky ,rese>* ,review 
,act4  #b4 ,life ,sci5ces ,rese>*       
,security ,bo>d  7a7 ,9 g5]al ,subtitle 
,v ( title #ca1 ,unit$ ,/ates ,code1 is 
am5d$ by add+ at ! end ! foll[+3  #gi   
,life ,sci5ces ,rese>* ,security ,bo>d  
#gija4 ,def9itions4 #gijb4 ,e/abli%m5t &
 memb]%ip4 #gijc4 ,bo>d p]sonnel4 #gijd4
 ,bo>d mission & functions4 #gije4      
,ag5cy proc$ures2 ref]ral to ,bo>d4     
#gijf4 ,bo>d review4 #gijg4 ,,gao       
,audits4 #gijh4 ,fund+4  #gija4         
,def9itions ,9 ?is *apt]3 7#a7 ,ag5cy ,!
 t]m ag5cy has ! mean+ giv5 ! t]m 9     

section #eeb7;f7 ( title #e4  7#b7      
,appropriate congressional committees ,!
 t]m appropriate congressional          
committees means ! ,committee on ,homel&
 ,security & ,gov]nm5tal ,affairs ( !   
,s5ate & ! ,committee on ,en]gy &       
,comm]ce ( ! ,h\se ( ,repres5tatives4   
7#c7 ,bo>d ,! t]m ,bo>d means ! ,life   
,sci5ces ,rese>* ,security ,bo>d        
e/abli%$ "u section #gijb7;a74  7#d7    
,dual use rese>* ( conc]n ,! t]m dual   
use rese>* ( conc]n-- 7,a7 means life   
sci5ces rese>* t1 bas$ on curr5t        
und]/&+1 c be reasonably anticipat$ to  
provide k1 in=mation1 products1 or      
te*nologies t c\ld--  7i7 be misappli$  
to d h>m ) no modification or only a    
m9or modification2 &  7ii7 pose a       
significant ?reat ) pot5tial consequ5ces
 to public heal? & safety1 agricultural 
crops & o!r plants1 animals1 mat]iel1 or
 national security2 &  7,b7 includes--  
7i7 life sci5ces rese>* t c\ld--  7,i7  
increase transmissibility ( a pa?og5 )9 
or betwe5 ho/ species2  7,,ii7 increase 

! virul5ce ( a pa?og5 or convey virul5ce
 to a non-pa?og52  7,,iii7 increase !   
toxicity ( a kn[n tox9 or produce a     
novel tox92  7,,iv7 increase--  7aa7 !  
/ability ( a pa?og5 or tox9 9 !         
environm5t2 or  7bb7 ! ability to       
dissem9ate a pa?og5 or tox92  7,v7 alt] 
! ho/ range or tropism ( a pa?og5 or    
tox92  7,,vi7 decrease ! ability = a    
human or vet]9>y pa?og5 or tox9 to be   
detect$ us+ /&>d diagno/ic or analytical
 me?ods2  7,,vii7 increase resi/ance ( a
 pa?og5 or tox9 to cl9ical or vet]9>y   
prophylactic or !rapeutic int]v5tions2  
7,,viii7 alt] a human or vet]9>y pa?og5 
or tox9 to disrupt ! effectiv5ess (     
pre-exi/+ immunity1 via immunization or 
natural infection1 aga9/ ! pa?og5 or    
tox92  7,,ix7 enhance ! susceptibility (
 a ho/ population to a pa?og5 or tox92  
7,x7 enhance transmissibility ( a pa?og5
 9 humans2  7,,xi7 enhance ! virul5ce ( 
a pa?og5 9 humans2  7,,xii7 enhance !   
immune evasion ( a pa?og5 9 humans1 su* 
z by modify+ ! pa?og5 to disrupt !      

effectiv5ess ( pre-exi/+ immunity via   
immunization or natural infection2 or   
7,,xiii7 g5]ate1 use1 recon/itute1 or   
transf] an eradicat$ or ext9ct          
high-consequ5ce pa?og52 &  7ii7 any o!r 
category ( life sci5ces rese>* t !      
,bo>d1 by majority vote ( ! memb]s ( !  
,bo>d1 id5tifies & publi%es 9 ! ,f$]al  
,regi/]4  7#e7 ,employee ,! t]m employee
 means an individual describ$ 9 section 
#baje7;a7 ( title #e4  7#f7 ,f$]al fund+
 ,! t]m ,f$]al fund+ means am\nts aw>d$ 
by an ag5cy pursuant to an intramural or
 extramural grant1 coop]ative agreem5t1 
int]ag5cy agreem5t1 contract1 or o!r    
in/rum5t4  7#g7 ,ga9 ( function rese>*  
,! t]m ga9 ( function rese>* means a    
rese>* exp]im5t t may enhance !         
transmissibility or virul5ce ( a        
high-consequ5ce pa?og54  7#h7           
,high-consequ5ce pa?og5 ,! t]m          
high-consequ5ce pa?og5--  7,a7 means a  
wild-type or syn!tic pa?og5 t-- 7i7 7,i7
 is likely capable ( wide &             
uncontrollable spread 9 human           

populations2 &  7,,ii7 w\ld likely cause
 mod]ate to sev]e disease or mortality 9
 humans2 or  7ii7 is--  7,i7 subject to 
subp>agraph 7,b71 influ5za ,a virus2    
7,,ii7 classifi$ "u subg5us             
,s>becovirus2  7,,iii7 classifi$ "u     
subg5us ,m]becovirus2  7,,iv7 ,v>iola   
or?opoxvirus2  7,v7 ,mpox or?opoxvirus2 
7,,vi7 ,nipah h5ipavirus2  7,,vii7      
,h5dra h5ipavirus2  7,,viii7 ,ebola     
or?oebolavirus2  7,,ix7 ,m>burg         
m>burgvirus2  7,x7 ,lassa mamm>5avirus2 
7,,xi7 ,jun9 ar5avirus2  7,,xii7        
,crimean-,congo hemorrhagic fev]        
or?onairovirus2  7,,xiii7 ,hantaan      
or?ohantavirus2  7,,xiv7 ,s9 ,nombre    
or?ohantavirus2  7,,xv7 ,y]s9ia pe/is2  
7,,xvi7 a select ag5t or tox91 "w ) :i* 
poses a significant risk ( delib]ate    
misuse2  7,,xvii7 any o!r pa?og5 or     
category ( pa?og5 t a majority ( memb]s 
( ! ,bo>d-- 7aa7 id5tifies z a          
high-consequ5ce pa?og52 &  7bb7 publi%es
 9 ! ,f$]al ,regi/]2 or  7,,xviii7 any  
syn!tic con/ruct ( a pa?og5 or category 

( pa?og5 describ$ 9 ?is clause2 &  7,b7 
does n include a seasonal influ5za      
virus1 unless a seasonal influ5za virus 
has be5 manipulat$ to include g5etic    
sequ5ces f a pa?og5 describ$ 9          
subp>agraph 7,a74  7#i7 ,high-risk life 
sci5ces rese>* ,! t]m high-risk life    
sci5ces rese>* means life sci5ces rese>*
 t is--  7,a7 dual use rese>* ( conc]n  
involv+ a high-consequ5ce pa?og52 or    
7,b7 ga9 ( function rese>*4  7#aj7 ,life
 sci5ces rese>* ,! t]m life sci5ces     
rese>*-- 7,a7 means ! /udy or use ( a   
liv+ organism1 a virus1 or a product ( a
 liv+ organism or virus2 &  7,b7        
includes ea* discipl9e1 me?odology1 &   
application ( biology1 includ+          
biote*nology1 g5omics1 proteomics1      
bio9=matics1 & ph>maceutical & biom$ical
 rese>* & te*niques4  7#aa7 ,select ag5t
 or tox9 ,! t]m select ag5t or tox9     
means a select ag5t or tox9 id5tifi$    
"u--  7,a7 section #gc4c7;b7 ( title    
#db1 ,code ( ,f$]al ,regulations1 z 9   
effect on ! date ( enactm5t ( ! ,risky  

,rese>* ,review ,act2  7,b7 section     
#cca4c7;b7 ( title #g1 ,code ( ,f$]al   
,regulations1 z 9 effect on ! date (    
enactm5t ( ! ,risky ,rese>* ,review     
,act2 or  7,c7 section #aba4c7;b7 (     
title #i1 ,code ( ,f$]al ,regulations1 z
 9 effect on ! date ( enactm5t ( !      
,risky ,rese>* ,review ,act4  #gijb4    
,e/abli%m5t & memb]%ip  7a7 ,e/abli%m5t 
,!re is e/abli%$ z an indep5d5t ag5cy )9
 ! ,executive ,bran* a bo>d to be kn[n z
 ! ,life ,sci5ces ,rese>* ,security     
,bo>d to review propos$ ,f$]al fund+ =  
life sci5ces rese>* 9 accordance )      
section #gijf4  7b7 ,appo9tm5t ( memb]s 
7#a7 ,9 g5]al ,! ,presid5t %all appo9t1 
)\t reg>d to political affiliation1 #i  
individuals :o are citiz5s ( ! ,unit$   
,/ates to s]ve z memb]s ( ! ,bo>d = n m 
?an #b t]ms ( #d ye>s ea*1 includ+--    
7,a7 ! ,executive ,director appo9t$ "u  
section #gijc7;a72  7,b7 #e             
nongov]nm5tal sci5ti/s 9 a life sci5ces 
field2  7,c7 #b nongov]nm5tal national  
security exp]ts2 &  7,d7 #a             

nongov]nm5tal biosafety exp]t4  7#b7    
,p]iod = nom9ations ,! ,presid5t %all   
make appo9tm5ts1 o!r ?an ! ,executive   
,director1 to ! ,bo>d n lat] ?an #cj    
days aft] ! date ( enactm5t ( ?is *apt]4
  7#c7 ,consid]ations ( recomm5dations  
,! ,presid5t %all make appo9tm5ts to !  
,bo>d aft] consid]+ individuals         
recomm5d$ by ! *air & rank+ memb] ( !   
appropriate congressional committees4   
7#d7 ,qualifications ,individuals       
appo9t$ to ! ,bo>d--  7,a7 %all-- 7i7 be
 imp>tial individuals2 &  7ii7 be       
di/+ui%$ individuals ( high national    
pr(essional reputation 9 _! respective  
fields :o are capable ( ex]cis+ !       
indep5d5t & objective judgm5t necess>y  
to conduct an imp>tial assessm5t ( !    
pot5tial risks & b5efits associat$ )    
,f$]al fund+ ( high-risk life sci5ces   
rese>* to public heal? & national       
security2 &  7,b7 may n be an employee  
on ! date ( ! appo9tm5t or dur+ ! #c-ye>
 p]iod prec$+ ! date ( ! appo9tm5t4     
7#e7 ,limitations ,n m ?an #d concurr5t 

memb]s ( ! ,bo>d may be an employee1 a  
subcontractor1 a previ\s employee1 or a 
previ\s subcontractor (-- 7,a7 !        
,dep>tm5t ( ,def5se2  7,b7 ! ,dep>tm5t (
 ,homel& ,security2  7,c7 ! ,national   
,in/itute ( ,all]gy & ,infecti\s        
,diseases ( ! ,dep>tm5t ( ,heal? &      
,human ,s]vices2  7,d7 ! ,(fice ( !     
,director ( ,national ,intellig5ce2 or  
7,e7 ! ,dep>tm5t ( ,en]gy4  7#f7        
,consid]ation by ! ,s5ate  7,a7 ,9 g5]al
 ,nom9ations = appo9tm5t to ! ,executive
 ,director ( ! ,bo>d %all be ref]r$ to !
 ,committee on ,homel& ,security &      
,gov]nm5tal ,affairs ( ! ,s5ate =       
consid]ation4  7,b7 ,r5om9ation ,a memb]
 ( ! ,bo>d :o is recomm5d$ to s]ve a    
second t]m %all be nom9at$ = appo9tm5t  
to ! ,bo>d1 & su* nom9ation %all be     
ref]r$ pursuant to subp>agraph 7,a74    
7#g7 ,vacancy ,n lat] ?an #cj days aft] 
! date on :i* a vacancy on ! ,bo>d      
occurs1 ! vacancy %all be fill$ 9 ! same
 mann] z specifi$ = ! orig9al appo9tm5t4
  7#h7 ,removal  7,a7 ,9 g5]al ,no memb]

 ( ! ,bo>d %all be remov$ f (fice1 o!r  
?an by--  7i7 impea*m5t & conviction2   
7ii7 ! action ( ! ,presid5t =           
ineffici5cy1 neglect ( duty1 malfeasance
 9 (fice1 physical disability1 m5tal    
incapacity1 or any o!r condition t      
sub/antially impairs ! p]=mance ( !     
memb]'s duties2 or  7iii7 ! ,bo>d 9     
accordance ) subp>agraph 7,b74  7,b7    
,action by ,bo>d ,if ! ,director ( !    
,(fice ( ,gov]nm5t ,e?ics det]m9es t    
p>ticipation by a memb] ( ! ,bo>d 9     
high-risk life sci5ces rese>* con/itutes
 a conflict ( int]e/1 ! ,bo>d %all take 
/eps to mitigate or manage ! conflict1  
:i* may include removal4  7,c7 ,notice (
 removal by ,presid5t  7i7 ,9 g5]al ,9 !
 case ( ! removal ( a memb] ( ! ,bo>d by
 ! ,presid5t z describ$ 9 subp>agraph   
7,a77ii71 n lat] ?an #aj days aft] !    
removal1 ! ,presid5t %all submit to !   
*air & rank+ memb] ( ! appropriate      
congressional committees a report       
specify+ ! facts f\nd & ! gr\nds =      
removal4  7ii7 ,publication ( report ,! 

,presid5t %all publi% 9 ! ,f$]al ,regi/]
 ea* report submitt$ "u clause 7i71     
except t ! ,presid5t may1 if necess>y to
 protect ! rights ( a p]son nam$ 9 !    
report or to prev5t undue int]f]5ce )   
any p5d+ prosecution1 po/pone or refra9 
f publicly publi%+ any or all ( ! report
 until ! completion ( su* p5d+ cases or 
pursuant to privacy protection          
requirem5ts 9 law4  7c7 ,m&atory        
conflicts ( int]e/ review  7#a7 ,9 g5]al
 ,! ,bo>d1 9 consultation ) ! ,director 
( ! ,(fice ( ,gov]nm5t ,e?ics1 %all--   
7,a7 n lat] ?an #ahj days aft] ! date ( 
! enactm5t ( ?is *apt]--  7i7 e/abli%   
crit]ia to det]m9e :e!r !re is a        
conflict ( int]e/ ) respect to any      
individual appo9t$ to ! ,bo>d1 tak+ into
 consid]ation requirem5ts "u ,f$]al law 
relat+ to e?ics requirem5ts = employees2
 &  7ii7 ^u an appo9tm5t ( a memb] to ! 
,bo>d "u subsection 7a77#a7 !reaft]1    
conduct a review ( ea* individual       
nom9at$ & appo9t$ to ! ,bo>d to ensure !
 individual does n h any conflict (     

int]e/ "u ! crit]ia e/abli%$ pursuant to
 clause 7i72 &  7,b7 p]iodically        
!reaft]1 conduct a review ( ea*         
individual nom9at$ & appo9t$ to ! ,bo>d 
to ensure ! individual does n h any     
conflict ( int]e/ "u ! crit]ia e/abli%$ 
pursuant to subp>agraph 7,a77i7 dur+ !  
t]m ( s]vice ( ! individual4  7#b7      
,notification  7,a7 ,9 g5]al ,n lat] ?an
 #c days aft] ! date on :i* ! ,director 
( ! ,(fice ( ,gov]nm5t ,e?ics becomes   
aw>e t a memb] ( ! ,bo>d possesses a    
pot5tial conflict ( int]e/ "u ! crit]ia 
e/abli%$ pursuant to p>agraph           
7#a77;,a77i71 ! ,director ( ! ,(fice (  
,gov]nm5t ,e?ics %all notify ! *air &   
rank+ memb] ( ! appropriate             
congressional committees ( ! pot5tial   
conflict ( int]e/4  7,b7 ,notification  
by memb] ,n lat] ?an #cj days aft] !    
date on :i* a memb] ( ! ,bo>d becomes   
aw>e t ano!r memb] ( ! ,bo>d possesses a
 pot5tial conflict ( int]e/ "u ! crit]ia
 e/abli%$ pursuant to p>agraph          
7#a77;,a77i71 ! memb] ( ! ,bo>d or !    

,executive ,director ( ! ,bo>d %all     
notify ! *air & rank+ memb] ( !         
appropriate congressional committees ( !
 pot5tial conflict ( int]e/4  7d7       
,security cle>ances ,all memb]s ( !     
,bo>d %all be grant$ all ! necess>y     
security cle>ances & accesses1 includ+  
to relevant ,presid5tial & dep>tm5t or  
ag5cy special access & comp>tm5t$ access
 programs1 9 an accel]at$ mann]1 subject
 to ! /&>d proc$ures = grant+ su*       
cle>ances4 ,all nom9ees = appo9tm5t to !
 ,bo>d %all qualify = ! necess>y        
security cle>ances & accesses prior to  
be+ consid]$ = confirmation by !        
,committee on ,homel& ,security &       
,gov]nm5tal ,affairs ( ! ,s5ate4  7e7   
,p>ticipation 9 high-,risk life sci5ces 
rese>*  7#a7 ,disclosure requir$ ,a     
memb] ( ! ,bo>d %all disclose :e!r !    
memb] has p>ticipat$ 9 or is curr5tly   
p>ticipat+ 9 high-risk life sci5ces     
rese>*4  7#b7 ,conflicts ( int]e/  7,a7 
,9 g5]al ,! p>ticipation 9 high-risk    
life sci5ces rese>* by a memb] ( !      

,bo>d--  7i7 %all be consid]$ a pot5tial
 conflict ( int]e/2 &  7ii7 %all be     
subject to scrut9y by ! ,director ( !   
,(fice ( ,gov]nm5t ,e?ics4  7,b7        
,det]m9ation ,if ! ,director ( ! ,(fice 
( ,gov]nm5t ,e?ics det]m9es t           
p>ticipation by a memb] ( ! ,bo>d 9     
high-risk life sci5ces rese>* con/itutes
 a conflict ( int]e/1 ! ,bo>d %all take 
/eps to mitigate or manage ! conflict1  
:i* may include-- 7i7 ! recusal ( !     
affect$ memb] f relevant discussions &  
det]m9ations2 &  7ii7 removal ( !       
affect$ memb] f ! ,bo>d4  7f7           
,comp5sation ( memb]s  7#a7 ,9 g5]al    
,subject to su* rules z may be adopt$ by
 ! ,bo>d1 )\t reg>d to ! provisions (   
*apt] #ea & sub*apt] ,,iii ( *apt] #ec (
 title #e relat+ to classification &    
,g5]al ,s*$ule pay rates1 a memb] ( !   
,bo>d1 o!r ?an ! ,executive ,director1  
%all be comp5sat$ at a rate--  7,a7     
propos$ by ! ,executive ,director &     
approv$ by ! ,bo>d2  7,b7 n to exce$ !  
rate ( basic pay = level ,,ii ( !       

,executive ,s*$ule2 &  7,c7 t is        
comm5surate )-- 7i7 ! "t a memb] ( !    
,bo>d sp5ds engag$ 9 ! p]=mance ( duties
 on ! ,bo>d2 &  7ii7 necess>y travel+   
exp5ses4  7#b7 ,outside employm5t       
,subject to t]ms & approval det]m9$ by !
 ,director ( ! ,(fice ( ,gov]nm5t       
,e?ics1 a memb] ( ! ,bo>d may ma9ta9    
outside employm5t & affiliations :ile   
s]v+ on ! ,bo>d4  7g7 ,ov]sight  7#a7   
,s5ate ,! ,committee on ,homel&         
,security & ,gov]nm5tal ,affairs ( !    
,s5ate %all-- 7,a7 h cont9u+ legislative
 ov]sight jurisdiction 9 ! ,s5ate )     
respect to ! (ficial conduct ( ! ,bo>d &
 ag5cy compliance ) requirem5ts issu$ by
 ! ,bo>d2 &  7,b7 h access to any       
records provid$ to or creat$ by ! ,bo>d4
  7#b7 ,h\se ( ,repres5tatives ,!       
,committee on ,en]gy & ,comm]ce ( !     
,h\se ( ,repres5tatives %all--  7,a7 h  
cont9u+ legislative ov]sight            
jurisdiction 9 ! ,h\se ( ,repres5tatives
 ) respect to ! (ficial conduct ( !     
,bo>d & ag5cy compliance ) requirem5ts  

issu$ by ! ,bo>d2 &  7,b7 h access to   
any records provid$ to or creat$ by !   
,bo>d4  7#c7 ,duty to coop]ate ,! ,bo>d 
%all h ! duty to coop]ate ) ! ex]cise ( 
ov]sight jurisdiction describ$ 9 ?is    
subsection4  7#d7 ,security cle>ances ,!
 *air & rank+ memb] ( ! appropriate     
congressional committees1 & designat$   
committee /aff1 %all be grant$ all      
security cle>ances & accesses held by ! 
,bo>d1 includ+ to relevant ,presid5tial 
& dep>tm5t or ag5cy special access &    
comp>tm5t$ access programs4  7h7 ,(fice 
space  7#a7 ,9 g5]al ,9 select+ (fice   
space = ! ,bo>d1 ! ,bo>d %all exhau/    
options = unus$ (fice spaces own$ by !  
,f$]al ,gov]nm5t z ( ! date ( enactm5t (
 ?is *apt]4  7#b7 ,secure (fice space   
7,a7 ,reque/s ,9 ord] to review or      
discuss classifi$ in=mation1 ! ,bo>d    
%all reque/ an accommodation f relevant 
ag5cies to access s5sitive comp>tm5t$   
in=mation facilities on an z-ne$$ basis4
  7,b7 ,fulfilm5t ,! head ( an ag5cy f  
:i* ! ,bo>d reque/s an accommodation "u 

subp>agraph 7,a7 %all accommodate !     
reque/ 9 a timely mann]4  #gijc4 ,bo>d  
p]sonnel  7a7 ,executive director  7#a7 
,appo9tm5t ,n lat] ?an #de days aft] !  
date ( enactm5t ( ?is *apt]1 ! ,presid5t
 %all appo9t1 by & ) ! advice & cons5t (
 ! ,s5ate1 #a individual :o is a citiz5 
( ! ,unit$ ,/ates1 )\t reg>d to         
political affiliation1 to ! position (  
,executive ,director ( ! ,bo>d = a t]m (
 #d ye>s4  7#b7 ,qualifications ,!      
individual appo9t$ z ,executive         
,director "u p>agraph 7#a7 %all be a    
private individual ( integrity &        
imp>tiality :o-- 7,a7 is a di/+ui%$     
sci5ti/ 9 a life sci5ces field2 &  7,b7 
is n1 & has n be5 = ! #c-ye> p]iod      
prec$+ ! date ( ! appo9tm5t-- 7i7 an    
employee2 or  7ii7 a p>ticipant 9       
high-risk life sci5ces rese>* support$  
by ,f$]al fund+4  7#c7 ,security        
cle>ances  7,a7 ,9 g5]al ,a c&idate =   
,executive ,director ( ! ,bo>d %all be  
grant$ all security cle>ances & accesses
 held by ! ,bo>d1 includ+ to relevant   

,presid5tial & dep>tm5t or ag5cy special
 access & comp>tm5t$ access programs 9  
an accel]at$ mann]1 subject to ! /&>d   
proc$ures = grant+ su* cle>ances4  7,b7 
,qualification prior to appo9tm5t ,!    
,presid5t %all ensure t a c&idate =     
,executive ,director ( ! ,bo>d qualifies
 = ! security cle>ances & accesses      
describ$ 9 subp>agraph 7,a7 prior to    
appo9tm5t4  7#d7 ,functions ,!          
,executive ,director ( ! ,bo>d %all--   
7,a7 s]ve z pr9cipal liaison to         
,congress & ag5cies2  7,b7 s]ve z *air (
 ! ,bo>d2  7,c7 be responsible = !      
adm9i/ration & coord9ation ( !          
responsibilities ( ! ,bo>d2 &  7,d7 be  
responsible = ! adm9i/ration ( all      
(ficial activities conduct$ by ! ,bo>d4 
7#e7 ,removal ,not)/&+ section          
#gijb7;b77#h71 ! ,executive ,director   
%all n be remov$ = reasons o!r ?an =    
cause on ! gr\nds ( ineffici5cy1 neglect
 ( duty1 malfeasance 9 (fice1 physical  
disability1 m5tal incapacity1 or any o!r
 condition t sub/antially impairs !     

p]=mance ( ! responsibilities ( !       
,executive ,director or ! /aff ( !      
,bo>d4  7#f7 ,t]ms ,an ,executive       
,director ( ! ,bo>d %all n s]ve m ?an #b
 t]ms4  7b7 ,/aff  7#a7 ,9 g5]al ,)\t   
reg>d to ! provisions ( sub*apt] ,i (   
*apt] #cc ( title #e gov]n+ appo9tm5ts 9
 ! competitive s]vice1 ! ,bo>d may      
appo9t n m ?an #be additional p]sonnel  
to enable ! ,bo>d & ! ,executive        
,director to p]=m ! duties ( ! ,bo>d4   
7#b7 ,qualifications ,ea* individual    
appo9t$ to ! /aff ( ! ,bo>d--  7,a7 %all
 be a citiz5 ( ! ,unit$ ,/ates (        
integrity & imp>tiality2  7,b7 %all h   
exp]tise 9 ! life sci5ces field or !    
national security field2 &  7,c7 may n  
be a p>ticipant 9 any f$]ally fund$     
rese>* activity on ! date ( ! appo9tm5t 
or dur+ ! c\rse ( s]vice ( ! individual 
on ! ,bo>d4  7#c7 ,security cle>ances   
7,a7 ,9 g5]al ,a c&idate = appo9tm5t to 
! /aff ( ! ,bo>d %all be grant$ all     
security cle>ances & accesses held by ! 
,bo>d1 includ+ to relevant ,presid5tial 

& dep>tm5t or ag5cy special access &    
comp>tm5t$ access programs1 9 an        
accel]at$ mann]1 subject to ! /&>d      
proc$ures = grant+ su* cle>ances4  7,b7 
,conditional employm5t  7i7 ,9 g5]al ,! 
,bo>d may (f] conditional employm5t to a
 c&idate = a /aff position ( ! ,bo>d    
p5d+ ! completion ( security cle>ance   
backgr\nd inve/igations4 ,dur+ ! p5d5cy 
( su* inve/igations1 ! ,bo>d %all ensure
 t any su* employee does n h access to1 
or responsibility involv+1 classifi$ or 
o!rwise re/rict$ mat]ials4  7ii7        
,unqualifi$ /aff ,if ! ,bo>d det]m9es t 
an individual hir$ on a conditional     
basis "u clause 7i7 is n eligible or    
o!rwise does n qualify = all security   
cle>ances necess>y to c>ry out !        
responsibilities ( ! position = :i*     
conditional employm5t has be5 (f]$1 !   
,bo>d %all imm$iately t]m9ate !         
individual's employm5t4  7#d7 ,support f
 ag5cies  7,a7 ,9 g5]al ,! head ( ea*   
ag5cy %all designate n less ?an #a      
full-"t employee ( ! ag5cy z !          

repres5tative ( ! ag5cy to-- 7i7 provide
 te*nical assi/ance to ! ,bo>d2 &  7ii7 
support ! review process ( ! ,bo>d )    
respect to ! ag5cy "u section #gijf 9 a 
non-vot+ /aff capacity4  7,b7           
,prohibition ,a repres5tative ( an ag5cy
 designat$ "u subp>agraph 7,a7 & any    
employee ( an ag5cy may n directly or   
indirectly influ5ce 9 any capacity a    
det]m9ation by ! ,bo>d "u section #gijf 
) respect to life sci5ces rese>* fund$  
by ! ag5cy4  7c7 ,comp5sation ,subject  
to su* rules z may be adopt$ by ! ,bo>d1
 )\t reg>d to ! provisions ( title #e   
gov]n+ appo9tm5ts 9 ! competitive s]vice
 & )\t reg>d to ! provisions ( *apt] #ea
 & sub*apt] ,,iii ( *apt] #ec ( t title 
relat+ to classification & ,g5]al       
,s*$ule pay rates1 ! ,executive         
,director ( ! ,bo>d %all-- 7#a7 be      
comp5sat$ at a rate n to exce$ ! rate ( 
basic pay = level ,,ii ( ! ,executive   
,s*$ule2  7#b7 s]ve ! entire t5ure z    
,executive ,director z #a full-"t       
employee2 &  7#c7 appo9t & fix !        

comp5sation ( su* o!r p]sonnel z may be 
necess>y to c>ry out ?is *apt]4  #gijd4 
,bo>d mission & functions  7a7 ,mission 
,! mission ( ! ,bo>d %all be to issue an
 indep5d5t det]m9ation z to :e!r an     
ag5cy may aw>d ,f$]al fund+ = propos$   
high-risk life sci5ces rese>*1 :i* %all 
be b9d+ ^u ! ag5cy4  7b7 ,p[]s ,! ,bo>d 
%all h ! au?ority to act 9 a mann] to   
c>ry out ! mission describ$ 9 subsection
 7a71 includ+ au?ority to--  7#a7       
prescribe regulations to c>ry out !     
responsibilities ( ! ,bo>d2  7#b7       
e/abli% a process = ! review ( ,f$]al   
fund+ = high-risk life sci5ces rese>*   
prior to ! aw>d ( ! ,f$]al fund+1 :i*   
%all be b9d+ ^u an ag5cy1 includ+       
in=mation designat$ z classifi$ or      
o!rwise protect$ f disclosure2  7#c7    
direct an ag5cy to make available to !  
,bo>d additional in=mation & records1   
includ+ in=mation designat$ z classifi$ 
or o!rwise protect$ f disclosure1 t !   
,bo>d det]m9es are requir$ to fulfill ! 
functions & responsibilities ,bo>d "u   

?is *apt]2  7#d7 review any classifi$   
rese>* conduct$ or fund$ by any ag5cy to
 det]m9e :e!r ! rese>* w\ld be consid]$ 
high-risk life sci5ces rese>*2 &  7#e7  
?r\gh ! promulgation ( regulations1     
e/abli% processes1 policies1 & proc$ures
 ( ! ,bo>d = r5d]+ decisions "u ?is     
*apt]4  7c7 ,initial requirem5ts ,!     
,bo>d %all--  7#a7 n lat] ?an #ahj days 
aft] ! date ( appo9tm5t ( ! initial     
memb]s ( ! ,bo>d "u section #gijb1      
publi% proc$ures 9 ! ,f$]al ,regi/]     
e/abli%+ ! process = ! review by ! ,bo>d
 "u section #gijf2  7#b7 prior to !     
e/abli%m5t ( ! proc$ures "u p>agraph    
7#a71 consult ) ! appropriate           
congressional committees & heads (      
ag5cies = purposes ( develop+ su*       
proc$ures2 &  7#c7 n lat] ?an #bgj days 
aft] ! date ( ! enactm5t ( ?is *apt]1   
beg9 c>ry+ out ! duties describ$ 9      
section #gijf4  7d7 ,responsiv5ess to   
,congress ,not)/&+ any o!r provision (  
law1 n lat] ?an #cj days aft] ! date on 
:i* ! ,bo>d receives a reque/ =         

in=mation f a ,memb] ( ,congress1 !     
,bo>d %all respond to ! reque/4  7e7    
,congressional brief+s ,n less frequ5tly
 ?an qu>t]ly1 ! ,bo>d %all brief !      
appropriate congressional committees on 
! "w ( ! ,bo>d4  7f7 ,select ag5t or    
tox9 updates  7#a7 ,9 g5]al ,n lat] ?an 
#ae days aft] ! date on :i* ! ,bo>d     
receives a notification t a select ag5t 
or tox9 has be5 add$ to a li/ ( ag5t or 
tox9s "u a regulation describ$ 9        
p>agraph 7#b71 ! ,bo>d %all--  7,a7     
review ! select ag5t or tox92  7,b7 by  
majority vote ( memb]s ( ! ,bo>d1       
det]m9e :e!r ! select ag5t or tox9 %\ld 
be add$ into ! def9ition ( select ag5t  
or tox9 "u section #gija2 &  7,c7 publi%
 any addition det]m9$ "u subp>agraph    
7,b7 9 ! ,f$]al ,regi/]4  7#b7          
,regulations describ$ ,a regulation     
describ$ 9 ?is p>agraph is--  7,a7      
section #gc4c7;b7 ( title #db1 ,code (  
,f$]al ,regulations1 or any successor   
regulation2  7,b7 section #cca4c7;b7 (  
title #g1 ,code ( ,f$]al ,regulations1  

or any successor regulation2 &  7,c7    
section #aba4c7;b7 ( title #i1 ,code (  
,f$]al ,regulations1 or any successor   
regulation4  7g7 ,f9al det]m9ation      
au?ority ,9 any dispute ) an ag5cy or   
entity relat+ to ! classification ( life
 sci5ces rese>* "u ?is *apt]1 ! ,bo>d   
%all reta9 f9al & ultimate au?ority 9-- 
7#a7 det]m9+ :e!r ! life sci5ces rese>* 
is high-risk life sci5ces rese>*1 dual  
use rese>* ( conc]n involv+ a           
high-consequ5ce pa?og5 or ga9 ( function
 rese>*2  7#b7 int]pret+ def9itions 9   
section #gija2 &  7#c7 det]m9+ :e!r a   
propos$ ,f$]al aw>d = life sci5ces      
rese>* is subject to ! review process ( 
! ,bo>d "u section #gijf7;a77#a74       
#gije4 ,ag5cy proc$ures2 ref]ral to     
,bo>d  7a7 ,9 g5]al  7#a7 ,prohibition  
,! head ( an ag5cy may n aw>d ,f$]al    
fund+ =--  7,a7 high-risk life sci5ces  
rese>* )\t approval by ! ,bo>d "u       
section #gijf7;a77#a77;,b72 or  7,b7    
life sci5ces rese>* if ! ,bo>d1 9       
accordance ) section                    

#gijf7;a77#b77;,a77ii71 submits         
notification to ! ag5cy "u section      
#gijf7;a77#b77;,b77i7 t ,bo>d is review+
 ! ,f$]al fund+ = life sci5ces rese>* "u
 section #gijf7;a7 until ! date on :i* !
 ,bo>d makes a f9al det]m9ation )       
respect to ! propos$ ,f$]al fund+4  7#b7
 ,effective date ,p>agraph 7#a7 %all    
take effect on ! date t is #ahj days    
aft] ! date ( enactm5t ( ?is *apt]4  7b7
 ,high-,risk atte/ation2 select ag5t or 
tox9 disclosure2 c]tification  7#a7 ,9  
g5]al ,an entity seek+ ,f$]al fund+ f an
 ag5cy = life sci5ces rese>* %all1 "u ! 
p5alty ( p]jury--  7,a7 atte/ :e!r-- 7i7
 ! life sci5ces rese>* w con/itute      
high-risk life sci5ces rese>*2 &  7ii7 !
 entity is p]=m+ active rese>* ) a      
select ag5t or tox92 &  7,b7 if ! entity
 makes a positive atte/ation "u         
subp>agraph 7,a71 disclose ! s\rce (    
fund+ = all active rese>*4  7#b7 ,active
 rese>* ) select ag5ts or tox9s  7,a7 ,9
 g5]al ,! head ( an ag5cy t receives a  
disclosure f an entity "u p>agraph      

7#a77;,b7 %all submit to ! ,bo>d !      
disclosure4  7,b7 ,bo>d inquiries ,!    
,bo>d may contact an entity t submits a 
disclosure "u p>agraph 7#a77;,b7 to     
reque/ additional in=mation relat+ to ! 
disclosure4  7#c7 ,ag5cy c]tification   
7,a7 ,positive atte/ations ,! head ( an 
ag5cy mak+ an aw>d ( ,f$]al fund+ to an 
entity t makes a positive atte/ation "u 
p>agraph 7#a77;,a77i7 %all-- 7i7 submit 
to ! ,bo>d ! high-risk life sci5ces     
proposal2 &  7ii7 us+ ! process e/abli%$
 by ! head ( ! ag5cy "u p>agraph 7#d71  
c]tify ! validity ( ! atte/ation4  7,b7 
,negative atte/ations ,! head ( an ag5cy
 mak+ an aw>d ( ,f$]al fund+ to an      
entity t makes a negative atte/ation "u 
p>agraph 7#a77;,a77i7 %all--  7i7 review
 ! atte/ation2 &  7ii7 us+ ! process    
e/abli%$ by ! head ( ! ag5cy "u p>agraph
 7#d71 c]tify ! validity ( ! atte/ation4
  7#d7 ,process = review ,! head ( ea*  
ag5cy t aw>ds ,f$]al fund+ = life       
sci5ces rese>*1 9 consultation ) !      
,bo>d1 %all e/abli% & implem5t a process

 = id5tify+ proposals f entities seek+  
,f$]al fund+ = life sci5ces rese>* f !  
ag5cy t w con/itute high-risk life      
sci5ces rese>*4  7#e7 ,ma9t5ance (      
records ,! head ( ea* ag5cy %all--  7,a7
 ma9ta9 records ( ! c]tification process
 describ$ 9 p>agraph 7#c7 = ea*         
application = ,f$]al fund+ 9 accordance 
) *apt] #ca ( title #dd2 &  7,b7 make ! 
records ma9ta9$ "u subp>agraph 7,a7     
available = audit & review ^u reque/ by 
! ,bo>d4  7c7 ,notification  7#a7 ,9    
g5]al ,n lat] ?an #cj days be=e ! date  
on :i* ! head ( an ag5cy plans to aw>d  
,f$]al fund+ to an entity = life sci5ces
 rese>*1 ! head ( ! ag5cy %all submit to
 ! ,bo>d a notification ( ! propos$     
,f$]al fund+4  7#b7 ,cont5ts ,!         
notification ( ,f$]al fund+ = life      
sci5ces rese>* requir$ "u p>agraph 7#a7 
%all include ! atte/ation & c]tification
 requir$ "u subsection 7b74  7#c7 ,bo>d 
reque/s  7,a7 ,9 g5]al ,! ,bo>d may     
reque/ additional in=mation f ! head (  
an ag5cy relat+ to a notification       

submitt$ "u p>agraph 7#a74  7,b7        
,provision ( in=mation ,! head ( an     
ag5cy f :i* ! ,bo>d reque/ additional   
in=mation "u subp>agraph 7,a7 %all      
provide ! in=mation 9 a timely mann]4   
7d7 ,ag5cy proc$ures ,n lat] ?an #ahj   
days aft] ! date on :i* ! ,bo>d publi%es
 ! process ( ! ,bo>d 9 ! ,f$]al ,regi/] 
pursuant to section #gijd7;c71 ! head ( 
ea* ag5cy %all publi% on ! website ( !  
ag5cy prepaym5t & preaw>d proc$ures ( ! 
ag5cy ) respect to ,f$]al fund+ = life  
sci5ces rese>* to-- 7#a7 gu>antee t--   
7,a7 all high-risk life sci5ce rese>*   
proposals are ref]r$ to ! ,bo>d be=e !  
aw>d ( ,f$]al fund+ by ! ag5cy2  7,b7 no
 ,f$]al fund+ = high-risk life sci5ces  
rese>* is aw>d$ by ! ag5cy )\t approval 
by ! ,bo>d2 &  7,c7 n lat] ?an #cj days 
be=e ! date on :i* ! head ( ! ag5cy     
plans to aw>d ! ,f$]al fund+1 ! ag5cy   
notifies ! ,bo>d ( ! proposal = ,f$]al  
fund+2 &  7#b7 o!rwise ensure compliance
 ) ?is *apt]4  7e7 ,provision (         
additional in=mation ,^u reque/ by !    

,bo>d1 ! head ( an ag5cy %all provide   
any in=mation relat+ to ,f$]al fund+    
aw>ds = life sci5ces rese>* det]m9$     
necess>y by ! ,bo>d to provide ov]sight 
( ! ag5cy4  7f7 ,*ange 9 circum/ances   
dur+ rese>* ,if1 dur+ ! c\rse ( life    
sci5ces rese>* 9 progress p]=m$ by an   
entity support$ by ,f$]al fund+ f an    
ag5cy1 circum/ances arise su* t ! life  
sci5ces rese>* 9 progress may con/itute 
high-risk life sci5ces rese>* 9         
contrav5tion to ! atte/ation ( ! entity 
"u subsection 7b77#a77;,a77i7--  7#a7 ! 
entity %all-- 7,a7 n lat] ?an #bd h\rs  
aft] ! id5tification ( ! *ange 9        
circum/ance1 pause ! life sci5ces rese>*
 9 progress2 &  7,b7 n lat] ?an #e days 
aft] ! date ( ! id5tification ( ! *ange 
9 circum/ance1 submit to ! head ( !     
ag5cy a writt5 notification ?r\gh an    
electronic or nonelectronic             
communication me?od t-- 7i7 notifies !  
head ( ! ag5cy ( ! possibility t ! life 
sci5ces rese>* 9 progress may con/itute 
high-risk life sci5ces rese>*2 &  7ii7  

includes a detail$ description ( ea*    
*ange 9 circum/ance t may trans=m ! life
 sci5ces rese>* 9 progress into         
high-risk life sci5ces rese>*2 &  7#b7 !
 head ( ! ag5cy %all--  7,a7 us+ !      
process ( ! ag5cy e/abli%$ "u subsection
 7b77#d71 det]m9e :e!r ! life sci5ces   
rese>* 9 progress con/itutes high-risk  
life sci5ces rese>*2  7,b7 if ! head ( !
 ag5cy makes a negative det]m9ation "u  
subp>agraph 7,a71 in=m ! entity t !     
entity may resume ! life sci5ces rese>* 
9 progress2 &  7,c7 if ! head ( ! ag5cy 
makes a positive det]m9ation "u         
subp>agraph 7,a71 imm$iately submit to !
 ,bo>d a notification ( ! ,f$]al fund+ (
 high-risk life sci5ces rese>* 9        
progress = review "u section            
#gijf7;a77#a74  7g7 ,en=cem5t  7#a7     
,applicant requirem5ts ,if an entity    
seek+ or receiv+ ,f$]al fund+ f an ag5cy
 kn[+ly fails to make a true atte/ation 
"u subsection 7b77#a7 or promptly notify
 ! ag5cy ( a *ange 9 circum/ance 9      
accordance ) subsection 7f77#a71 ! head 

( ! ag5cy %all ref] ! entity to !       
appropriate entity = susp5sion & deb>m5t
 proce$+s relat+ to ! receipt ( ,f$]al  
fund+4  7#b7 ,ref]ral to inspector g5]al
 ,! ,bo>d %all ref] any employee ( an   
ag5cy responsible = ov]see+ & review+   
rese>* proposals relat+ to ,f$]al fund+ 
t kn[+ly fails to comply ) subsection   
7b77#c7 to ! inspector g5]al ( ! ag5cy4 
7#c7 ,employee discipl9e  7,a7 ,9 g5]al 
,! head ( an ag5cy employ+ an employee  
:o kn[+ly violates any provision (      
subsection 7b77#c7 7or1 9 ! case ( !    
head ( an ag5cy :o violates any         
provision ( subsection 7b77#c71 !       
,presid5t7 %all impose on t employee--  
7i7 discipl9>y action 9 accordance )    
*apt] #ge ( title #e or an equival5t    
proc$ure ( ! ag5cy2 &  7ii7 p]man5t     
revocation ( any applicable security    
cle>ance held by ! employee4  7,b7      
,contractor p5alty ,9 ! case (          
contractor work+ "u a contract ) an     
ag5cy :o kn[+ly violates subsection     
7b77#a71 ! head ( ! ag5cy %all ref] !   

contractor to ! appropriate entity =    
susp5sion & deb>m5t proce$+s relat+ to !
 receipt ( ,f$]al fund+4  7,c7 ,employee
 discipl9e reports  7i7 ,9 g5]al ,n lat]
 ?an #cfj days aft] ! date ( enactm5t ( 
?is ,act1 & n less frequ5tly ?an once e 
#ij days !reaft]1 ! head ( ea* ag5cy    
%all submit to ! ,bo>d & ! appropriate  
congressional committees a report t     
discloses1 = ! p]iod cov]$ by ! report1 
ea* violation by an employee ( ! ag5cy (
 subsection 7b77#c74  7ii7 ,cont5ts ,ea*
 report submitt$ "u clause 7i7 %all     
include1 ) respect to a violation       
describ$ 9 t clause-- 7,i7 ! "n &       
pr(essional title ( ea* employee engag$ 
9 ! violation2  7,,ii7 a detail$        
explanation ( ! nature ( ! violation2 & 
7,,iii7 ! date ( ! violation4  7iii7    
,publication ,n lat] ?an #e days aft] ! 
date on :i* ! ,bo>d receives a report "u
 clause 7i71 ! ,bo>d %all publi% on a   
publicly accessible & se>*able website !
 am\nt ( violations t h be5 committ$ "u 
clause 7i74  7h7 ,subaw>d &             

subcontractor disclosure  7#a7 ,9 g5]al 
,dur+ ! c\rse ( high-risk life sci5ces  
rese>* 9 progress p]=m$ by an entity    
support$ by ,f$]al fund+ f an ag5cy1 !  
entity %all--  7,a7 cont9u\sly disclose 
to ! head ( ! ag5cy any subcontracts or 
subaw>ds made or plann$ to be made ) !  
,f$]al fund+2 &  7,b7 obta9 cons5t f !  
head ( ! ag5cy be=e aw>d+ a subcontract 
or aw>d describ$ 9 subp>agraph 7,a74    
7#b7 ,ag5cy submission ,n lat] ?an #cj  
days aft] ! date on :i* ! head ( an     
ag5cy receives a disclosure "u p>agraph 
7#a71 ! head ( ! ag5cy %all submit to ! 
,bo>d ! disclosure4  7#c7 ,bo>d         
inquiries  7,a7 ,9 g5]al ,! ,bo>d may   
contact an entity t submits a disclosure
 "u p>agraph 7#a7 to reque/ additional  
in=mation relat+ to ! disclosure4  7,b7 
,access to reports ,dur+ ! c\rse (      
high-risk life sci5ces rese>* 9 progress
 p]=m$ by an entity support$ by ,f$]al  
fund+ f an ag5cy1 ^u reque/1 ! ,bo>d    
%all h access to e annual report (-- 7i7
 ! ag5cy2  7ii7 ! entity p]=m+ !        

high-risk life sci5ces rese>*2 &  7iii7 
any subcontractor or subaw>dee ( an     
entity describ$ 9 clause 7ii74  #gijf4  
,bo>d review  7a7 ,9 g5]al  7#a7        
,high-risk life sci5ces rese>* ,n lat]  
?an #abj days aft] ! date on :i* ! ,bo>d
 receives a notification f an ag5cy "u  
section #gije7;c7 relat+ to propos$     
,f$]al fund+ = life sci5ces rese>* t    
con/itutes high-risk life sci5ces rese>*
 or ! ,bo>d receives a notification f an
 ag5cy "u section #gije7;f77#b77;,c7    
relat+ to ,f$]al fund+ ( rese>* 9       
progress t con/itutes high-risk life    
sci5ces rese>*1 ! ,bo>d %all-- 7,a7     
review ! propos$ ,f$]al fund+ or        
high-risk life sci5ces rese>* 9         
progress2  7,b7 by a majority vote1     
det]m9e :e!r ! ag5cy may aw>d ! propos$ 
,f$]al fund+ or cont9ue to aw>d ! ,f$]al
 fund+ = ! high-risk life sci5ces rese>*
 9 progress2 &  7,c7 by a majority vote1
 det]m9e ) respect to ! high-risk life  
sci5ces rese>* fund$ by ! propos$ ,f$]al
 fund+ or ,f$]al fund+ = high-risk life 

sci5ces rese>* 9 progress--  7i7 !      
m9imum requir$ biosafety conta9m5t      
level1 eng9e]+ controls1 & op]ational   
controls2  7ii7 ! m9imum requir$        
biosecurity eng9e]+ controls &          
op]ational controls2 &  7iii7 ! m9imum  
requir$ p]sonnel assurance controls4    
7#b7 ,propos$ life sci5ces rese>*  7,a7 
,9 g5]al ,) respect to propos$ ,f$]al   
fund+ by an ag5cy = life sci5ces rese>*1
 ! ,bo>d may--  7i7 review ! propos$    
,f$]al fund+2 &  7ii7 det]m9e :e!r !    
,bo>d %\ld review ! propos$ ,f$]al fund+
 9 accordance ) p>agraph 7#a74  7,b7    
,notification ,if ! ,bo>d makes a       
positive det]m9ation "u subp>agraph     
7,a77ii7 ) respect to propos$ ,f$]al    
fund+ by an ag5cy-- 7i7 ! ,bo>d %all    
notify ! head ( ! ag5cy2 &  7ii7 ! head 
( ! ag5cy may n aw>d ! propos$ ,f$]al   
fund+ until ! date on :i* ! ,bo>d makes 
a f9al det]m9ation ) respect to !       
propos$ ,f$]al fund+ "u p>agraph 7#a74  
7#c7 ,pa/ fund+ ,) respect to life      
sci5ces rese>* p]=m$ ) ,f$]al fund+     

aw>d$ by an ag5cy be=e ! date ( enactm5t
 ( ?is *apt]1 ! ,bo>d may review & audit
 ! rese>* 9 ord] to assess ! compliance 
( ! ag5cy ) ! provisions ( ?is *apt]4   
7#d7 ,ongo+ fund+ = life sci5ces rese>* 
,) respect to ,f$]al fund+ = life       
sci5ces rese>* 9 progress aw>d$ by an   
ag5cy be=e ! date ( enactm5t ( ?is ,act 
t ! ,bo>d det]m9es may con/itute        
high-risk life sci5ces rese>*1 ! ,bo>d  
may-- 7,a7 direct ! ag5cy to tempor>ily 
susp5d ! ,f$]al fund+2  7,b7 require !  
ag5cy to provide complete in=mation on !
 ,f$]al fund+ 9 ord] = ! ,bo>d to       
complete a review ( ! life sci5ces      
rese>* "u p>agraph 7#a72 &  7,c7 by a   
majority vote ( memb]s ( ! ,bo>d1       
det]m9e :e!r ! ag5cy may cont9ue !      
,f$]al fund+4  7b7 ,consid]ations  7#a7 
,9 g5]al ,9 mak+ a det]m9ation "u       
subsection 7a77#a77;,b71 ! ,bo>d %all   
consid]1 ) respect to ! high-risk life  
sci5ces rese>* t w be conduct$ ) !      
propos$ ,f$]al fund+ or high-risk life  
sci5ces rese>* 9 progress-- 7,a7 :e!r ! 

rese>* poses a ?reat to public heal?2   
7,b7 :e!r ! rese>* poses a ?reat to     
public safety2  7,c7 :e!r ! rese>* has a
 high probability ( produc+ b5efits =   
public heal?2  7,d7 :e!r ! rese>* poses 
a ?reat to l>ge populations ( animals & 
plants2  7,e7 :e!r ! rese>* poses a     
?reat to national security2  7,f7 :e!r !
 rese>* is propos$ to be conduct$ 9 :ole
 or at lea/ 9 "p 9 a =eign c\ntry2  7,g7
 ! reasonably anticipat$ mat]ial risks (
 ! rese>*2  7,h7 ! reasonably anticipat$
 in=mation risks ( ! rese>*2  7,i7 !    
reasonably anticipat$ b5efits ( !       
rese>*2  7,j7 :e!r ! reasonably         
anticipat$ b5efits ( ! rese>* outweigh !
 reasonably anticipat$ risks2 &  7,k7   
:e!r ! b5efits ( ! rese>* c\ld be obta9$
 ?r\gh proc$ures pos+ l[] risks4  7#b7  
,weight ( factors ,! pres5ce or abs5ce (
 any factor "u p>agraph 7#a7 %all n be  
decisive ) respect to ! det]m9ation ( ! 
,bo>d "u subsection 7a77#a77;,b74  7c7  
,notice foll[+ review & det]m9ation     
7#a7 ,ag5cy notification ,n lat] ?an #e 

days aft] ! date on :i* ! ,bo>d makes a 
det]m9ation "u subsection 7a77#a77;,b7 )
 respect to ,f$]al fund+ by an ag5cy1 ! 
,executive ,director ( ! ,bo>d %all     
notify ! head ( ! ag5cy ( ! det]m9ation4
  7#b7 ,bo>d consultation  7,a7 ,9 g5]al
 ,n lat] ?an #aj days aft] receiv+ a    
notification f ! ,bo>d "u p>agraph 7#a71
 ! head ( an ag5cy may reque/ a meet+ ) 
! ,bo>d to discuss ! det]m9ation ( !    
,bo>d4  7,b7 ,bo>d response ,! ,bo>d    
%all s*$ule a meet+ reque/$ by ! head ( 
an ag5cy "u subp>agraph 7,a7 9 a timely 
mann]4  7#c7 ,notification to           
appropriate congressional committees ,if
 ! ,bo>d det]m9es t ! head ( an ag5cy   
may n proce$ ) an aw>d ( propos$ ,f$]al 
fund+ "u ?is section1 ! ,executive      
,director ( ! ,bo>d %all notify !       
appropriate congressional committees :5 
! ,bo>d notifies ! head ( ! ag5cy4  7d7 
,reque/ = exp$it$ review  7#a7          
,def9ition ,9 ?is subsection1 ! t]m     
em]g5cy rese>* means high-risk life     
sci5ces rese>* submitt$ to ! ,bo>d t    

relates to a public heal? em]g5cy or    
addresses a specific national security  
conc]n4  7#b7 ,reque/2 notification ,!  
head ( an ag5cy seek+ exp$it$ review f !
 ,bo>d to aw>d ,f$]al fund+ = em]g5cy   
rese>* %all-- 7,a7 include a reque/ =   
exp$it$ review 9 ! notification requir$ 
"u section #gije7;c72 &  7,b7 on ! date 
( ! notification describ$ 9 subp>agraph 
7,a71 submit to ! ,bo>d & ! appropriate 
congressional committees a notification 
t expla9s :y ! specific public heal?    
em]g5cy or national security conc]n     
necessitates exp$it$ review "u ?is      
subsection4  7#c7 ,int]nal process ,!   
,bo>d %all e/abli% an int]nal process "u
 :i* ! ,bo>d w give propos$ em]g5cy     
rese>* exp$it$ review "u ?is section4   
7#d7 ,tempor>y em]g5cy rese>* ,if !     
,bo>d does n notify ! head ( an ag5cy ) 
a det]m9ation "u subsection 7a77#a77;,b7
 ) respect to propos$ em]g5cy rese>* by 
! #ae days aft] ! date on :i* ! head ( !
 ag5cy submits a reque/ "u p>agraph     
7#b77;,a71 ! head ( ! ag5cy may aw>d    

,f$]al fund+ = ! em]g5cy rese>* on a    
tempor>y basis4  7e7 ,sci5tific exp]t   
panels  7#a7 ,9 g5]al ,! ,bo>d may      
e/abli% a sci5tific panel (             
nongov]nm5tal exp]ts to advise ! ,bo>d 9
 ! review by ! ,bo>d ( life sci5ces     
rese>* pursuant to ?is *apt]4  7#b7     
,policies & proc$ures ,! ,bo>d %all     
e/abli% & publi% 9 ! ,f$]al ,regi/]     
proc$ures & policies relat+ to conflicts
 ( int]e/1 recusal1 exp]tise1 & relat$  
matt]s be=e ! e/abli%m5t ( ! panel      
describ$ 9 p>agraph 7#a74  7#c7         
,prohibition ,an individual s]v+ on !   
panel e/abli%$ "u p>agraph 7#a7 may n   
advise ! ,bo>d on any matt] ) respect to
 :i* ! individuals has an id5tifi$ or   
p]ceiv$ conflict ( int]e/4  7#d7 ,report
  7,a7 ,9 g5]al ,n lat] ?an #cj days    
aft] ! date on :i* ! ,bo>d e/abli%es a  
panel e/abli%$ "u p>agraph 7#a71 ! ,bo>d
 %all submit to ! appropriate           
congressional committees a report t     
includes ! names1 qualifications1 & any 
id5tifi$ or p]ceiv$ conflicts ( int]e/ (

 individuals :o s]ve on ! panel4  7,b7  
,panel *anges ,^u a *ange ( p]sonnel on 
! panel e/abli%$ "u p>agraph 7#a71 !    
,bo>d %all imm$iately submit to !       
appropriate congressional committees an 
update to ! report requir$ "u           
subp>agraph 7,a74  7f7 ,report  7#a7 ,9 
g5]al ,n lat] ?an #cfj days aft] ! date 
on :i* ! ,bo>d e/abli%es ! panel        
describ$ 9 subsection 7e77#a71 &        
annually !reaft]1 ! ,bo>d %all submit to
 ! appropriate congressional committees 
a report1 :i* %all include a classifi$  
annex1 summ>iz+1 ) respect to ea*       
det]m9ation by ! ,bo>d "u ?is section   
relat+ to high-risk life sci5ces        
rese>*-- 7,a7 ! f9d+s ( ! ,bo>d2  7,b7 !
 det]m9ation ( ! ,bo>d2  7,c7 ! "n &    
location ( ! entity propos+ ! life      
sci5ces rese>*2  7,d7 ! "n & location ( 
any recipi5t ( a subaw>d or             
subcontractor ( an entity propos+ life  
sci5ces rese>* & ! nature ( !           
p>ticipation ( su* a recipi5t or        
subcontractor2 &  7,e7 an acc\nt (      

significant *all5ges or problems1       
includ+ proc$ural or sub/antive *all5ges
 or problems1 t arise dur+ ! c\rse ( !  
"w ( ! ,bo>d1 includ+ ! views ( any     
memb] ( ! ,bo>d :o wi%es to h ^? views  
includ$ 9 ! report4  7#b7 ,public report
 ,on ! date on :i* ! ,bo>d submits a    
report requir$ "u p>agraph 7#a71 ! ,bo>d
 %all make ! report1 o!r ?an ! classifi$
 annex includ$ 9 ! report1 available on 
a website4  7g7 ,effective date ,?is    
section %all take effect on ! date t is 
#bgj days aft] ! date ( enactm5t ( ?is  
*apt]4  #gijg4 ,,gao ,audits ,!         
,comptroll] ,g5]al ( ! ,unit$ ,/ates    
%all p]iodically audit ! ,bo>d4  #gijh4 
,fund+ ,!re is au?oriz$ to be           
appropriat$ to ! ,bo>d to c>ry out ?is  
*apt] #cj1jjj1jjj = ea* ( fiscal ye>s   
#bjbf ?r\gh #bjce4  4  7b7 ,cl]ical     
am5dm5t ,! table ( *apt]s = subtitle ,v 
( title #ca1 ,unit$ ,/ates ,code1 is    
am5d$ by add+ at ! end ! foll[+3  #gi4  
,life ,sci5ces ,rese>* ,security        
,bo>d#gija  4  7c7 ,f9ancial disclosure 

reports ( ,bo>d memb]s ,section         
#acajc7;f7 ( title #e1 ,unit$ ,/ates    
,code1 is am5d$--  7#a7 9 p>agraph      
7#aa71 by /rik+ & at ! end2  7#b7 9     
p>agraph 7#ab71 by /rik+ ! p]iod at !   
end & ins]t+ 2 &2 &  7#c7 by add+ at !  
end ! foll[+3  7#ac7 a memb] ( ! ,life  
,sci5ces ,rese>* ,security ,bo>d        
e/abli%$ "u section #gijb ( title #ca4  
4