#aai? ,,congress  #b;d ,session  ,s4    
#ahch  ,,an ,,act  ,to am5d ! ,public   
,heal? ,s]vice ,act to au?orize !       
,secret>y ( ,heal? & ,human ,s]vices to 
c>ry out a program ( rese>*1 tra9+1 &   
inve/igation relat$ to ,d[n syndrome1 & 
= o!r purposes4  #a4 ,%ort title ,?is   
,act may be cit$ z ! ,de,ondra ,dixon   
,,include ,project ,act ( #bjbf4  #b4   
,de,ondra ,dixon ,,include ,project ,"p 
,b ( title ,,iv ( ! ,public ,heal?      
,s]vice ,act 7#db ,u4,s4,c4 #bhd et     
seq47 is am5d$ by add+ at ! end !       
foll[+3  #dji,k4 ,d[n syndrome rese>*   
7a7 ,9 g5]al ,! ,director ( ,,nih %all  
c>ry out a program ( rese>*1 tra9+1 &   
inve/igation relat$ to ,d[n syndrome to 
be kn[n z ! ,i,nvestigation (           
,co-occurr+ conditions across !         
,lifespan to ,und]/& ,d[n syndrom,e     
,project or ! ,,include ,project4  7b7  
,program elem5ts ,! program "u          
subsection 7a7 %all include-- 7#a7      
high-risk1 high-rew>d rese>* on !       
effects ( trisomy #ba on human          

developm5t & heal?2  7#b7 promot+ rese>*
 = p>ticipants ) ,d[n syndrome across ! 
lifespan1 includ+ cohort /udies to      
facilitate improv$ und]/&+ ( ,d[n       
syndrome & co-occurr+ conditions &      
developm5t ( new int]v5tions2  7#c7     
exp&+ ! numb] ( cl9ical trials t are    
inclusive (1 or expressly =1 p>ticipants
 ) ,d[n syndrome1 includ+ novel         
biom$ical & ph>macological int]v5tions &
 o!r !rapies design$ to promote or      
enhance activities ( daily liv+2  7#d7  
rese>* on ! biological me*anisms 9      
individuals ) ,d[n syndrome p]ta9+ to   
/ructural1 functional1 & behavioral     
anomalies & dysfunction z well z /unt$  
gr[?2  7#e7 support+ rese>* to improve  
diagnosis & treatm5t ( conditions       
co-occurr+ ) ,d[n syndrome1 includ+ !   
id5tification ( biom>k]s relat$ to risk 
factors1 diagnosis1 & cl9ical rese>* &  
!rapeutics2  7#f7 rese>* on ! causes (  
increas$ preval5ce1 & concurr5t         
treatm5t1 ( co-occurr+ conditions1 su* z
 ,alzheim]'s disease & relat$ dem5tias &

 autoimmunity1 9 individuals ) ,d[n     
syndrome2 &  7#g7 rese>*1 tra9+1 &      
inve/igation on improv+ ! quality ( life
 ( individuals ) ,d[n syndrome & _!     
families4  7c7 ,coord9ation2 prioritiz+ 
nonduplicative rese>* ,! ,director (    
,,nih %all ensure t-- 7#a7 ! programs & 
activities ( ! in/itutes & c5t]s ( !    
,national ,in/itutes ( ,heal? relat+ to 
,d[n syndrome & co-occurr+ conditions   
are coord9at$1 includ+ ?r\gh ! ,(fice ( 
! ,director ( ,,nih & priority-sett+    
reviews conduct$ pursuant to section    
#djb7;b77#c72 &  7#b7 su* in/itutes &   
c5t]s1 prioritize1 z appropriate1 ,d[n  
syndrome rese>* t does n duplicate exi/+
 rese>* activities ( ! ,national        
,in/itutes ( ,heal?4  7d7 ,consultation 
) /akehold]s ,9 c>ry+ out activities "u 
?is section1 ! ,director ( ,,nih %all1 z
 appropriate & to ! maximum ext5t       
feasible1 consult ) relevant /akehold]s1
 includ+ pati5t advocates1 to ensure t  
su* activities take into consid]ation ! 
ne$s ( individuals ) ,d[n syndrome4  7e7

 ,bi5nial reports to ,congress  7#a7 ,9 
g5]al ,! ,director ( ,,nih %all submit1 
on a bi5nial basis1 to ! ,committee on  
,en]gy & ,comm]ce & ! ,subcommittee on  
,labor1 ,heal? & ,human ,s]vices1       
,education1 & ,relat$ ,ag5cies ( !      
,committee on ,appropriations ( ! ,h\se 
( ,repres5tatives & ! ,committee on     
,heal?1 ,education1 ,labor1 & ,p5sions &
 ! ,subcommittee on ,labor1 ,heal? &    
,human ,s]vices1 ,education1 & ,relat$  
,ag5cies ( ! ,committee on              
,appropriations ( ! ,s5ate1 a report t  
catalogs ! rese>* conduct$ or support$  
"u ?is section4  7#b7 ,cont5ts ,ea*     
report "u p>agraph 7#a7 %all include--  
7,a7 id5tification ( ! in/itute or c5t] 
involv$2  7,b7 a /atem5t ( :e!r ! rese>*
 is or 0 be+ c>ri$ out directly by su*  
in/itute or c5t] or by multiple         
in/itutes & c5t]s2 &  7,c7 id5tification
 ( any result+ real-_w evid5ce t is or  
may be us$ = cl9ical rese>* & m$ical c>e
 = pati5ts ) ,d[n syndrome4  4  ,pass$ !
 ,s5ate ,augu/ #f1 #bjbf4,secret>y