,,iv #aai? ,,congress #a/ ,session ,h4 ,,res4 #fja ,,9 ,,! ,,h\se ,,( ,,repres5tatives ,july #bc1 #bjbe,ms4 ,de,gette 7= h]self1 ,mr4 ,rask91 & ,mr4 ,au*9closs7 submitt$ ! foll[+ resolution2 :i* 0 ref]r$ to ! ,committee on ,en]gy & ,comm]ce ,,resolution ,recogniz+ ! duty ( ! ,f$]al ,gov]nm5t to lead ! _w 9 biom$ical rese>*4 ,:]eas ! model ( ,f$]al ,gov]nm5t fund+ to support free sci5tific inquiry 9 p>tn]%ip ) academia & indu/ry s9ce ,_w ,w> ,,ii has produc$ an unprec$5t$ increase 9 k ab\t m$ic9e & ! human body2 ,:]eas ! ,national ,in/itutes ( ,heal? has gr[n f a s+le laboratory at its f\nd+ 9 #ahhg to ! _w's lead+ grant-mak+ ag5cy & cr[n jewel ( biom$ical progress z ! _w's l>ge/ s+le public fund] ( biom$ical & behavioral rese>*2 ,:]eas ! ,f$]al ,gov]nm5t's unprec$5t$ inve/m5t 9 rese>* to solve milit>y m$ical *all5ges 9 ,_w ,w> ,,ii directly l$ to break?r\ghs su* z l>ge-scale p5icill9 production1 u%]$ 9 a gold5 age ( drug developm5t1 & provid$ ! f\ndation = ! ,national ,in/itutes ( ,heal? extramural rese>* program2 ,:]eas ! funds ( ! ,national ,in/itutes ( ,heal? support basic rese>* t enables d[n/ream sci5tific break?r\ghs b t _c be replicat$ 9 private sett+s1 z ?is rese>* (t5 _c be directly monetiz$ into a m>ketable good or s]vice or is consid]$ too e>ly-/age1 too risky1 or too complex = indu/ry inve/m5t2 ,:]eas rese>* support$ by ! ,national ,in/itutes ( ,heal? has und]p9n$ ne>ly e new drug approv$ by ! ,food & ,drug ,adm9i/ration 9 ! #ba/ c5tury2 ,:]eas f$]ally fund$ rese>* into ! hepatitis ,c virus pav$ ! way = direct-act+ antivirals t cure a previ\sly life-?reat5+ disease 9 #ie p]c5t ( cases2 ,:]eas ! dea? rate = ,,hiv_/,,aids has decreas$ f a peak ( #af4b p] #ajj1jjj 9 #aiie to #a4d p] #ajj1jjj today1 & #ej drugs are n[ available to manage ,,hiv2 ,:]eas ,national ,in/itutes ( ,heal? rese>* has improv$ und]/&+ ( ! causes1 prev5tion1 & treatm5t ( he>t disease1 lead+ 9 "p to a r$uction 9 ! dea? rate f he>t disease f #cjg p] #ajj1jjj 9 #aiej to #ace p] #ajj1jjj 9 #aiif1 & decreas$ rates ( /roke by #gj p]c5t 9 ?is same p]iod2 ,:]eas ! ,national ,in/itutes ( ,heal?'s m ?an #h1jjj1jjj1jjj annual inve/m5t 9 canc] rese>* g5]ates #fi1jjj1jjj1jjj 9 annual economic activity & #g1jjj1jjj jobs1 & has fuel$ a r$uction 9 ! canc] dea? rate 9 ! ,unit$ ,/ates by #cd p]c5t f #aiia to #bjbb1 av]t+ approximately #d1ejj1jjj dea?s2 ,:]eas rese>* fund$ by ! ,unit$ ,/ates ,gov]nm5t ov] #ce ye>s prior to ! ,,covid-#ai p&emic l$ to ! capability ( develop+ & deliv]+ effective vacc9es 9 "u #a ye>2 ,:]eas ! ,human ,g5ome ,project laun*$ ! g5omic revolution :ile produc+ #gif1jjj1jjj1jjj 9 economic returns = an inve/m5t ( only #c1hjj1jjj1jjj1 a return on inve/m5t ( #bji = e #a inve/$1 & ! ,all ( ,u ,rese>* ,program w enable a fur!r revolution 9 precision m$ic9e2 ,:]eas f$]ally support$ rese>* l$ to ! rec5t developm5t & use ( a miracul\s p]sonaliz$ g5e-edit+ !rapy to treat an infant ) a r>e1 incurable disease1 mak+ hi/ory & lay+ ! gr\ndwork to rapidly develop treatm5ts = o!r r>e g5etic diseases2 ,:]eas rese>*]s 9 ,am]ica1 due to sci5tific work=ce breat$ by public inve/m5t1 are uniquely position$ to address major *all5ges 9 public heal? & m$ic9e1 includ+-- 7#a7 an ag+ population1 ) ne>ly #eh1jjj1jjj ,am]icans age #fe or old] & increas+2 7#b7 approximately #f 9 #aj ,am]icans h at lea/ #a *ronic disease2 7#c7 m ?an #ij-p]c5t ( ! ,nation's #d1ejj1jjj1jjj1jjj 9 annual heal? c>e exp5ditures g to treat individuals ) *ronic diseases & m5tal heal? conditions2 7#d7 ov] #b1hjj1jjj antibiotic resi/ant infections occur 9 ! ,unit$ ,/ates annually2 7#e7 approximately #ide1jjj ,am]icans die ( he>t disease or /roke ea* ye>2 7#f7 approximately #b1jjj1jjj ,am]icans are diagnos$ ) canc] ea* ye> & ov] #fjj1jjj ,am]icans die f canc] ea* ye>2 7#g7 ov] #ch1jjj1jjj ,am]icans h diabetes1 & ov] #ih1jjj1jjj ,am]icans h pr$iabetes2 & 7#h7 ne>ly #g1jjj1jjj ,am]icans h ,alzheim]'s disease2 ,:]eas ! ,trump adm9i/ration has r$uc$ ! biom$ical rese>* capacity ( ! ,unit$ ,/ates & put ! ,unit$ ,/ates at risk ( los+ a g5]ation ( sci5tific tal5t2 ,:]eas ! ,trump adm9i/ration at its outset halt$ ,national ,in/itutes ( ,heal? advisory c\ncils & /udy sections1 effectively freez+ new grantmak+ activities2 ,:]eas ! ,trump adm9i/ration implem5t$ a communications freeze at ! ,dep>tm5t ( ,heal? & ,human ,s]vices1 prev5t+ rese>*]s at ,national ,in/itutes ( ,heal? ,cl9ical ,c5t] f meet+ ) pati5t gr\ps or recruit+ pati5ts = cl9ical trials ( new !rapies2 ,:]eas ! ,trump adm9i/ration's ban on rese>* 9 collaboration ) int]national p>tn]s or involv+ topics deem$ disfavor$ l$ to ! illegal t]m9ation or delay ( ne>ly #b1ejj m]itori\s grants at ! ,national ,in/itutes ( ,heal? 9 ! fir/ #d mon?s ( ! adm9i/ration2 ,:]eas ! ,trump adm9i/ration fir$ ?\s&s ( employees support+ critical biom$ical rese>* at ! ,dep>tm5t ( ,heal? & ,human ,s]vices1 includ+ at ! ,national ,canc] ,in/itute1 :]e ! adm9i/ration fir$ /aff responsible = dissem9at+ new evid5ce on canc] treatm5t & diagnosis1 leav+ doctors & pati5ts to access outdat$ in=mation1 & delay+ sci5tific progress t[>d f9d+ new treatm5ts & cures2 ,:]eas ! ,trump adm9i/ration has propos$ cutt+ fund+ = ! ,national ,in/itutes ( ,heal? by #dj-p]c5t & r$uc+ its #bg ,in/itutes & ,c5t]s to j #h1 :i* w\ld significantly und]m9e ! abilities ( ! ,in/itutes to effectuate _! core sci5tific missions & decimate progress t[>d und]/&+ & treat+ disease2 ,:]eas ! ,congressional ,budget ,(fice has f\nd t a #aj-p]c5t fund+ r$uction = ! ,national ,in/itutes ( ,heal? w\ld result 9 #b few] drugs com+ to m>ket ea* ye>2 ,:]eas ! ,trump adm9i/ration has1 = ! fir/ "t 9 ,national ,in/itutes ( ,heal?'s hi/ory1 plac$ political appo9tees 9 positions o!r ?an ! ,director & ! ,director ( ! ,national ,canc] ,in/itute1 includ+ )9 ! ,national ,in/itutes ( ,heal?'s ,in/itutes & ,c5t]s1 ?reat5+ ! indep5d5ce ( ! ,national ,in/itutes ( ,heal? sci5tific decision mak+1 & risk+ ! ,am]ican p's tru/ 9 ! ,national ,in/itutes ( ,heal?'s inve/m5ts1 /atem5ts1 & advice2 ,:]eas ! ,trump adm9i/ration is purg+ sci5ti/s :o are se5 z insuffici5tly align$ ) ! adm9i/ration's views f ,national ,in/itutes ( ,heal? processes2 ,:]eas ! ,trump adm9i/ration has halt$ fund+ allocat$ to lead+ academic rese>* in/itutions = lifesav+ rese>* z lev]age to a*ieve unrelat$ policy objectives1 !reby halt+ or delay+ ongo+ biom$ical rese>* projects2 & ,:]eas ! actions ( ! ,trump adm9i/ration h l$ our adv]s>ies to attempt to entice our rese>*]s & sci5ti/s to leave our %ores & relocate abroad3 ,n[1 !re=e1 be x ,t x is ! s5se ( ! ,h\se ( ,repres5tatives t-- 7#a7 ! biom$ical rese>* ( ! ,unit$ ,/ates & developm5t capacity is a national asset t mu/ be protect$1 improv$1 & exp&$2 7#b7 ,f$]al ,gov]nm5t ef=ts ?r\gh ! ,national ,in/itutes ( ,heal? ensure a robu/ biom$ical rese>* app>atus & support ! global role ( ! ,unit$ ,/ates z a lead] ( biom$ical advancem5t & innovation2 7#c7 ! biom$ical rese>* work=ce ( ! ,unit$ ,/ates1 includ+ ! public s]vants at ! ,national ,in/itutes ( ,heal? & o!r ,f$]al ag5cies1 %\ld be treat$ ) respect1 & ! jobs associat$ ) biom$ical rese>* %\ld (f] good pay & b5efits2 7#d7 protect+ public heal? mu/ be a :ole-(-gov]nm5t collaboration beg9n+ ) ! rese>* necess>y to advance public heal?2 7#e7 ,f$]al ,gov]nm5t support is integral to-- 7,a7 tra9+ new sci5ti/s 9 v>i$ public heal? & rese>* discipl9es2 7,b7 enc\rag+ & facilitat+ premi] sci5ti/s to /ay 9 ! ,unit$ ,/ates = _! c>e]s2 7,c7 ensur+ a robu/ field ( sci5ti/s 9 ! ,unit$ ,/ates :o are committ$ to ! advancem5t ( sci5ce1 public heal?1 & biom$ic9e2 & 7,d7 /ability ( biom$ical rese>* fund+ s t ,unit$ ,/ates-bas$ rese>*]s are focus$ on sci5ce & advancem5t r ?an adm9i/rative burd5s or political int]f]5ce2 7#f7 sci5tific decision mak+ 9 ! ,f$]al ,gov]nm5t %\ld be driv5 by ! be/ available evid5ce1 effectuat$ by pe]-review$ sci5ti/s1 & insulat$ f political int]f]5ce2 7#g7 ov] ! next decade1 ! ,f$]al ,gov]nm5t %\ld d\ble its inve/m5t 9 biom$ical rese>* & prop]ly apply+ ! f9d+s ( biom$ical rese>* to m$ical practice2 7#h7 ,f$]al biom$ical rese>* inve/m5ts %\ld-- 7,a7 support basic rese>* t improves our und]/&+ ( ! human body 9 all its div]sity1 & h[ ext]nal factors su* z life/yle factors1 social factors1 & environm5tal factors affect its function2 7,b7 support rese>* t seeks to cl>ify ! root causes ( diseases2 7,c7 support translational sci5ce t accel]ates access ( ,am]icans to novel treatm5ts2 7,d7 support pot5tially trans=mative high-risk1 high-rew>d rese>*2 7,e7 support & enable collaborative1 broad-bas$ res\rces t may be us$ across diff]5t rese>*]s & in/itutions2 7,f7 support & enable rese>* collaboration across individual rese>*]s & in/itutions & facilitate k %>+2 7,g7 s]ve a dual m&ate ( increas+ und]/&+ ( a p>ticul> sci5tific "q & increas+ ! capacity ( fund$ rese>*]s & in/itutions to p]=m future rese>* ( value2 7,h7 support transp>5cy1 acc\ntability1 & replicability 9 innovative biom$ical rese>*2 7,i7 support novel processes1 products1 & o!r innovations t h ! pot5tial to prev5t1 mitigate1 or cure disease1 p>ticul>ly ^? :i* may r$uce ov]all heal? c>e exp5ditures2 & 7,j7 support ! integration ( evid5ce g5]at$ by biom$ical rese>* into cl9ical practice1 includ+ by exp&+ p>tn]%ips ) ,f$]al heal? ag5cies1 heal? pr(essionals1 pati5ts1 heal? sy/ems1 payors1 indu/ry1 & community-bas$ organizations2 & 7#i7 x %\ld be ! policy ( ! ,f$]al ,gov]nm5t to inve/ 9 rese>* ) ! pot5tial to improve ! quality ( life = all ,am]icans & innovations 9 m$ic9e1 includ+-- 7,a7 rev]s+ ! rec5t decl9e 9 ,unit$ ,/ates life expectancy2 7,b7 develop+ te*nologies to ensure ! ability to prev5t & respond to microbial ?reats to humans & animals2 7,c7 id5tify+ ! und]ly+ causes ( neurog5]ative diseases & develop+ tools to r$uce ! burd5 ( su* diseases2 7,d7 r$uc+ ! dea? rate f canc] & improv+ ! quality ( life ( ^? diagnos$ ) canc]2 7,e7 r$uc+ ! burd5 ( ,alzheim]'s disease & relat$ dem5tias1 includ+ by develop+ evid5ce-bas$ tools to effectively prev5t ,alzheim]'s disease2 7,f7 r$uc+ ! numb] ( p :o die wait+ = transplantable organs to z]o2 7,g7 avoid+ prev5table diabetes diagnoses2 7,h7 r$uc+ dea?s f c>diovascul> disease1 includ+ /roke2 7,i7 develop+ v]satile !rapeutic plat=ms t c be repurpos$ = v>i\s applications1 includ+ treatm5ts = ultr>>e g5etic diseases2 7,j7 develop+ effective int]v5tions to prev5t & treat *ronic symptoms ( viral & bact]ial infections1 includ+ ,,covid-#ai1 ,lyme disease1 & ,ep/e9-,b>r virus2 7,k7 develop+ effective prev5tive vacc9es & !rapeutics = diseases t h hi/orically affect$ und]s]v$ populations worldwide & attract$ l[] levels ( inve/m5t1 su* z *ikungunya1 d5gue1 & mal>ia2 & 7,l7 improv+ repres5tation 9 cl9ical trials to ensure broad applicability ( sci5tific f9d+s & improve ! heal? ( und]s]v$ populations4