,i  #aah? ,,congress  #a/ ,session  ,h4 
,r4 #dgjb  ,,9 ,,! ,,h\se ,,(           
,,repres5tatives  ,july #ah1 #bjbc,ms4  
,e%oo introduc$ ! foll[+ bill2 :i* 0    
ref]r$ to ! ,committee on ,en]gy &      
,comm]ce  ,a ,,bill  ,to require !      
,secret>y ( ,heal? & ,human ,s]vices to 
prescribe a regulation r$uc+ ! risks 9  
g5e syn!sis products1 & = o!r purposes4 
#a4 ,%ort title ,?is ,act may be cit$ z 
! ,secur+ ,g5e ,syn!sis ,act4  #b4      
,requirem5ts = ! dissem9ation ( syn!tic 
g5etic mat]ial ,section #cea;,a ( !     
,public ,heal? ,s]vice ,act 7#db        
,u4,s4,c4 #bfb;a7 is am5d$--  7#a7 9    
subsection 7b77#b71 by /rik+ ! semicolon
 at ! end & ins]t+ ! foll[+3 1 includ+  
by--  7,a7 assess+ unc]ta9ties1 risks1  
co/s1 & b5efits associat$ ) !           
implem5tation ( diff]5t types (         
protocols or o!r regulations to r$uce ! 
risk ( pot5tial misuse ( de novo g5e    
syn!sis products2  7,b7 det]m9+ ! types 
( protocols or o!r regulations t c\ld   
detect ! pot5tial misuse ( de novo g5e  

syn!sis products :ile g5]at+ b5efits t  
are l>g] ?an _! co/s2  7,c7 requir+ g5e 
syn!sis provid]s or manufactur]s ( g5e  
syn!sis equipm5t to implem5t scre5+     
protocols to detect misuse ( de novo g5e
 syn!sis products2  7,d7 v]ify+ or      
provisionally v]ify+ t g5e syn!sis      
provid]s & manufactur]s ( g5e syn!sis   
equipm5t adh]e to ! regulation prescrib$
 pursuant to subp>agraph 7,c72 &  7,e7  
assess+1 collect+1 & waiv+ fees = en=c+ 
! regulation prescrib$ pursuant to      
subp>agraph 7,c72 &  7,f7 requir+ any   
entity receiv+ ,f$]al funds1 or any     
,f$]al ag5cy1 :i* pur*ases de novo g5e  
syn!sis products f a g5e syn!sis provid]
 or g5e syn!sis equipm5t f a manufactur]
 ( g5e syn!sis equipm5t to pur*ase su*  
products & equipm5t only if su* provid]s
 or manufactur]s are v]ifi$ or          
provisionally v]ifi$ pursuant to        
subp>agraph 7,d72  2  7#b7 9 subsection 
7e77#a71 by /rik+ ! p]iod at ! end &    
ins]t+ 1 includ+ ?r\gh ! revocation (   
,f$]al rese>* fund+ = any entity f\nd to

 be 9 violation ( subsection            
7b77#b77;,e71 or ?r\gh ! )hold+ ( su*   
fund+ = su* an entity until ! entity    
demon/rates compliance ) su*            
subsection42  7#c7 9 subsection 7k71 by 
add+ at ! end ! foll[+3  7#d7 ,use ( g5e
 syn!sis products & g5e syn!sis equipm5t
 by ,f$]al ag5cies ,n lat] ?an ,janu>y  
#a1 #bjbf1 ! ,secret>y %all report to ! 
appropriate committees ( ,congress a    
description ( ! policies & proc$ures    
adopt$ by all ag5cies t fund or conduct 
life sci5ces rese>* involv+ g5e syn!sis 
products or g5e syn!sis equipm5t to     
comply ) ?is section4  2  7#d7 9        
subsection 7l7--  7,a7 by r$esignat+    
p>agraphs 7#b71 7#c71 7#d71 7#e71 7#f71 
7#g71 & 7#h7 z p>agraphs 7#e71 7#f71    
7#h71 7#i71 7#aj71 7#aa71 & 7#ab71      
respectively2  7,b7 by ins]t+ aft]      
p>agraph 7#a7 ! foll[+3  7#b7 ,! t]m g5e
 syn!sis equipm5t means equipm5t t c    
produce g5e syn!sis product1 reg>dless (
 ! te*nical me*anism by :i* su* equipm5t
 works4  7#c7 ,! t]m g5e syn!sis        

product--  7,a7 means cu/om s+le-/r&$ or
 d\ble-/r&$ ,,dna1 or s+le-/r&$ or      
d\ble-/r&$ ,,rna1 :i* has be5 *emically 
or enzymatically syn!siz$ or o!rwise    
manufactur$ de novo & is ( a l5g? exce$+
 ! scre5+ ?re%old2 &  7,b7 does n       
include--  7i7 base *emical subunits1   
su* z individual nucleotides or         
nucleosides1 or oligonucleotides %ort]  
?an ! scre5+ ?re%old typically us$ z    
polym]ase *a9 reaction prim]s2  7ii7    
byproducts g5]at$ dur+ sequ5c+ t are n  
useful = assembly or clon+1 z det]m9$ by
 ! ,secret>y2 or  7iii7 products g5]at$ 
f clon+ or assembl+ ( exi/+ g5e or g5e  
fragm5t mat]ial1 9 circum/ances 9 :i* ! 
g5e syn!sis provid] has no access or    
notice to ! sequ5ce design1 z det]m9$ by
 ! ,secret>y4  7#d7 ,! t]m g5e syn!sis  
provid]--  7,a7 means-- 7i7 an entity t 
creates g5e syn!sis product = deliv]y to
 a cu/om] 9 ! ,unit$ ,/ates2 or  7ii7 a 
di/ributor ( g5e syn!sis product 9 !    
,unit$ ,/ates1 includ+ an entity t      
manufactures g5e syn!sis product = use  

by ano!r p>ty1 :e!r su* o!r p>ty is     
inside & outside ( ! entity2 &  7,b7    
does n include--  7i7 an entity mak+ g5e
 syn!sis products = ! entity's own use1 
9 circum/ances 9 :i* ! sequ5ce has be5  
previ\sly scre5$ 9 compliance ) ?is     
section2  7ii7 an entity t manufactures 
g5e syn!sis products 9 ! process (      
develop+ or manufactur+ ano!r product = 
a cu/om]1 unless ! g5e syn!sis product  
is provid$ to ! end us] !re(2 or  7iii7 
any class ( entity t ! ,secret>y *ooses 
to exempt1 aft] consid]ation ( ! co/s & 
b5efits ( exempt+ t class ( entity f    
regulation "u ?is section z a g5e       
syn!sis provid]4  2  7,c7 by ins]t+ aft]
 p>agraph 7#f71 z s r$esignat$1 !       
foll[+3  7#g7 ,! t]m manufactur] ( g5e  
syn!sis equipm5t means an entity t      
produces = sale g5e syn!sis equipm5t4  2
 &  7,d7 by add+ at ! end ! foll[+3     
7#ac7 ,! t]m scre5+ ?re%old means !     
m9imal l5g? ( de novo g5e syn!sis       
product :i* ensures t ! results ( su*   
scre5+ conta9 en\gh in=mation to all[ an

 unambigu\s analysis ( su* product's    
pot5tial misuse4  2 &  7#e7 9 subsection
 7m71 by /rik+ = ea* ( ! fiscal ye>s    
#bjbc ?r\gh #bjbg & ins]t+ = fiscal ye> 
#bjbc & ea* subsequ5t fiscal ye>4