,,ii  #aaf? ,,congress  #b;d ,session   
,s4 #cgcd  ,,9 ,,! ,,s5ate ,,( ,,!      
,,unit$ ,,/ates  ,may #ad1 #bjbj,mrs4   
,gillibr& 7= h]self1 ,mr4 ,m>key1 ,mr4  
,rubio1 & ,mr4 ,g>dn]7 introduc$ !      
foll[+ bill2 :i* 0 read twice & ref]r$  
to ! ,committee on ,comm]ce1 ,sci5ce1 & 
,transportation  ,a ,,bill  ,to provide 
= a coord9at$ ,f$]al rese>* initiative  
to ensure cont9u$ ,unit$ ,/ates lead]%ip
 9 eng9e]+ biology4  #a4 ,%ort title    
,?is ,act may be cit$ z ! ,bioeconomy   
,rese>* & ,developm5t ,act ( #bjbj4  #b4
 ,f9d+s ,! ,congress makes ! foll[+     
f9d+s3 7#a7 ,cellul> & molecul>         
processes may be us$1 mimick$1 or       
r$esign$ to develop new products1       
processes1 & sy/ems t improve societal  
well-be+1 /r5g!n national security1 &   
contribute to ! economy4  7#b7 ,eng9e]+ 
biology relies on a work=ce ) a div]se &
 unique set ( skills comb9+ !           
biological1 physical1 *emical1 &        
in=mation sci5ces & eng9e]+4  7#c7      
,long-t]m rese>* & developm5t is        

necess>y to create break?r\ghs 9 eng9e]+
 biology4 ,su* rese>* & developm5t      
requires gov]nm5t inve/m5t z _m ( !     
b5efits are too di/ant or unc]ta9 =     
indu/ry to support alone4  7#d7 ,rese>* 
is necess>y to in=m evid5ce-bas$        
gov]nance ( eng9e]+ biology & to support
 ! gr[? ( ! eng9e]+ biology indu/ry4    
7#e7 ,! ,f$]al ,gov]nm5t has an         
obligation to ensure t e?ical1 legal1   
environm5tal1 safety1 security1 &       
societal implications ( its sci5ce &    
te*nology rese>* & inve/m5t foll[s      
policies ( responsible innovation &     
fo/]s public transp>5cy4  7#f7 ,! ,f$]al
 ,gov]nm5t c play an important role by  
facilitat+ ! developm5t ( tools &       
te*nologies to fur!r advance eng9e]+    
biology1 includ+ us] facilities1 by     
facilitat+ public-private p>tn]%ips1 by 
support+ risk rese>*1 & by facilitat+ ! 
comm]cial application 9 ! ,unit$ ,/ates 
( rese>* fund$ by ! ,f$]al ,gov]nm5t4   
7#g7 ,! ,unit$ ,/ates l$ ! developm5t ( 
! sci5ce & eng9e]+ te*niques t creat$ ! 

field ( eng9e]+ biology1 b due to       
increas+ int]national competition1 !    
,unit$ ,/ates is at risk ( los+ its     
competitive advantage if does n inve/ ! 
necess>y res\rces & h a national        
/rategy4  7#h7 ,a ,national ,eng9e]+    
,biology ,initiative c s]ve to e/abli%  
new rese>* directions & te*nology goals1
 improve int]ag5cy coord9ation & plann+ 
processes1 drive te*nology transf] to ! 
private sector1 & help ensure optimal   
returns on ! ,f$]al inve/m5t4  #c4      
,def9itions ,9 ?is ,act3 7#a7           
,biomanufactur+ ,! t]m biomanufactur+   
means ! utilization ( biological sy/ems 
to develop new & advance exi/+ products1
 tools1 & processes at comm]cial scale4 
7#b7 ,eng9e]+ biology ,! t]m eng9e]+    
biology means ! application ( eng9e]+   
design pr9ciples & practices to         
biological sy/ems1 includ+ molecul> &   
cellul> sy/ems1 to advance fundam5tal   
und]/&+ ( complex natural sy/ems & to   
enable novel or optimize functions &    
capabilities4  7#c7 ,initiative ,! t]m  

,initiative means ! ,national ,eng9e]+  
,biology ,rese>* & ,developm5t          
,initiative e/abli%$ "u section #d4     
7#d7 ,omics ,! t]m omics ref]s to !     
collective te*nologies us$ to explore ! 
roles1 relation%ips1 & actions ( ! v>i\s
 types ( molecules t make up ! cells (  
an organism4  #d4 ,national ,eng9e]+    
,biology ,rese>* & ,developm5t          
,initiative  7a7 ,9 g5]al ,! ,presid5t1 
act+ ?r\gh ! ,(fice ( ,sci5ce &         
,te*nology ,policy1 %all implem5t a     
,national ,eng9e]+ ,biology ,rese>* &   
,developm5t ,initiative to advance      
societal well-be+1 national security1   
su/a9ability1 & economic productivity & 
competitiv5ess ?r\gh-- 7#a7 advanc+     
areas ( rese>* at ! int]section ( !     
biological1 physical1 *emical1 data1 &  
computational sci5ces & eng9e]+ to      
accel]ate sci5tific und]/&+ &           
te*nological innovation 9 eng9e]+       
biology2  7#b7 advanc+ areas (          
biomanufactur+ rese>* to optimize1      
/&>dize1 scale1 & deliv] new products & 

solutions2  7#c7 support+ social &      
behavioral sci5ces & economics rese>* t 
advances ! field ( eng9e]+ biology &    
contributes to ! developm5t & public    
und]/&+ ( new products1 processes1 &    
te*nologies2  7#d7 improv+ ! und]/&+ (  
eng9e]+ biology ( ! sci5tific & lay     
public & support+ great] evid5ce-bas$   
public disc\rse ab\t its b5efits &      
risks2  7#e7 support+ risk rese>*1      
includ+ "u subsection 7d72  7#f7        
support+ ! developm5t ( novel tools &   
te*nologies to accel]ate sci5tific      
und]/&+ & te*nological innovation 9     
eng9e]+ biology2  7#g7 exp&+ ! numb] (  
rese>*]s1 educators1 & /ud5ts ) eng9e]+ 
biology tra9+1 includ+ f traditionally  
und]repres5t$ & und]s]v$ populations2   
7#h7 accel]at+ ! translation &          
comm]cialization ( eng9e]+ biology      
rese>* & developm5t by ! private sector2
 &  7#i7 improv+ ! int]ag5cy plann+ &   
coord9ation ( ,f$]al ,gov]nm5t          
activities relat$ to eng9e]+ biology4   
7b7 ,initiative activities ,! activities

 ( ! ,initiative %all include-- 7#a7    
su/a9$ support = eng9e]+ biology rese>* 
& developm5t ?r\gh-- 7,a7 grants to     
individual inve/igators & teams (       
inve/igators1 includ+ int]discipl9>y    
teams2  7,b7 projects fund$ "u jo9t     
solicitations by a collaboration ( no   
few] ?an two ag5cies p>ticipat+ 9 !     
,initiative2 &  7,c7 int]discipl9>y     
rese>* c5t]s t are organiz$ to          
inve/igate basic rese>* que/ions1 c>ry  
out te*nology developm5t & demon/ration 
activities1 & increase und]/&+ ( h[ to  
scale up eng9e]+ biology processes1     
includ+ biomanufactur+2  7#b7 su/a9$    
support = databases & relat$ tools1     
includ+-- 7,a7 support = curat$ g5omics1
 epig5omics1 & all o!r relevant omics   
databases1 includ+ plant & microbial    
databases1 t are available to rese>*]s  
to c>ry out eng9e]+ biology rese>*2     
7,b7 developm5t ( /&>ds = su* databases1
 includ+ = curation1 int]op]ability1 &  
protection ( privacy & security2  7,c7  
support = ! developm5t ( computational  

tools1 includ+ artificial intellig5ce   
tools1 t c accel]ate rese>* & innovation
 us+ su* databases2 &  7,d7 an inv5tory 
& assessm5t ( all ,f$]al ,gov]nm5t omics
 databases to id5tify opportunities =   
consolidation & in=m inve/m5t 9 su*     
databases z critical infra/ructure = !  
eng9e]+ biology rese>* ent]prise2  7#c7 
su/a9$ support = ! developm5t1          
optimization1 & validation ( novel tools
 & te*nologies to enable ! dynamic /udy 
( molecul> processes 9 situ1 includ+    
?r\gh-- 7,a7 rese>* conduct$ at ,f$]al  
laboratories2  7,b7 grants to           
inve/igators at in/itutions ( high]     
education & o!r nonpr(it rese>*         
in/itutions2 &  7,c7 ?r\gh ! ,small     
,bus9ess ,innovation ,rese>* ,program & 
! ,small ,bus9ess ,te*nology ,transf]   
,program1 z describ$ 9 section #i ( !   
,small ,bus9ess ,act 7#ae ,u4,s4,c4     
#fch72  7#d7 education & tra9+ (        
und]graduate & graduate /ud5ts 9 eng9e]+
 biology1 9 biomanufactur+1 9 bioprocess
 eng9e]+1 & 9 areas ( computational     

sci5ce appli$ to eng9e]+ biology & 9 !  
relat$ e?ical1 legal1 environm5tal1     
safety1 security1 & o!r societal issues2
  7#e7 activities to develop robu/      
me*anisms = track+ & quantify+ ! outputs
 & economic b5efits ( eng9e]+ biology2 &
  7#f7 activities to accel]ate !        
translation & comm]cialization ( new    
products1 processes1 & te*nologies by-- 
7,a7 id5tify+ precompetitive rese>*     
opportunities2  7,b7 facilitat+         
public-private p>tn]%ips 9 eng9e]+      
biology rese>* & developm5t2  7,c7      
connect+ rese>*]s1 graduate /ud5ts1 &   
po/doctoral fell[s ) entrepr5eur%ip     
education & tra9+ opportunities2 &  7,d7
 support+ pro( ( concept activities & ! 
=mation ( />tup companies includ+ ?r\gh 
programs su* z ! ,small ,bus9ess        
,innovation ,rese>* ,program & ! ,small 
,bus9ess ,te*nology ,transf] ,program4  
7c7 ,exp&+ p>ticipation ,! ,initiative  
%all include1 to ! maximum ext5t        
practicable1 outrea* to prim>ily        
und]graduate & m9ority-s]v+ in/itutions 

ab\t ,initiative opportunities1 & %all  
enc\rage ! developm5t ( rese>*          
collaborations betwe5 rese>*-int5sive   
univ]sities & prim>ily und]graduate &   
m9ority-s]v+ in/itutions4  7d7 ,e?ical1 
legal1 environm5tal1 safety1 security1 &
 societal issues ,initiative activities 
%all take into acc\nt e?ical1 legal1    
environm5tal1 safety1 security1 & o!r   
appropriate societal issues by-- 7#a7   
support+ rese>*1 includ+ 9 ! social     
sci5ces1 & o!r activities address+      
e?ical1 legal1 environm5tal1 & o!r      
appropriate societal issues relat$ to   
eng9e]+ biology1 includ+ integrat+      
rese>* on su* topics ) ! rese>* &       
developm5t 9 eng9e]+ biology1 & ensur+ t
 ! results ( su* rese>* are widely      
dissem9at$1 includ+ ?r\gh int]discipl9>y
 eng9e]+ biology rese>* c5t]s describ$ 9
 subsection 7b77#a72  7#b7 support+     
rese>* & o!r activities relat$ to !     
safety & security implications ( eng9e]+
 biology1 includ+ outrea* to increase   
aw>5ess among ,f$]al rese>*]s & f$]ally 

fund$ rese>*]s at in/itutions ( high]   
education ab\t pot5tial safety &        
security implications ( eng9e]+ biology 
rese>*1 z appropriate2  7#c7 ensur+ t   
input f ,f$]al & non-,f$]al exp]ts on ! 
e?ical1 legal1 environm5tal1 safety1    
security1 & o!r appropriate societal    
issues relat$ to eng9e]+ biology is     
integrat$ into ! ,initiative2 &  7#d7   
ensur+1 ?r\gh ! ag5cies & dep>tm5ts t   
p>ticipate 9 ! ,initiative1 t public    
input & outrea* are integrat$ into !    
,initiative by ! conv5+ ( regul> & ongo+
 public discussions ?r\gh me*anisms su* 
z work%ops1 cons5sus conf]5ces1 &       
educational ev5ts1 z appropriate4  #e4  
,initiative coord9ation  7a7 ,int]ag5cy 
committee ,! ,presid5t1 act+ ?r\gh !    
,(fice ( ,sci5ce & ,te*nology ,policy1  
%all designate an int]ag5cy committee to
 coord9ate eng9e]+ biology1 :i* %all be 
co-*air$ by ! ,(fice ( ,sci5ce &        
,te*nology ,policy1 & include           
repres5tatives f ! ,national ,sci5ce    
,f\ndation1 ! ,dep>tm5t ( ,en]gy1 !     

,dep>tm5t ( ,def5se1 ! ,national        
,a]onautics & ,space ,adm9i/ration1 !   
,national ,in/itute ( ,/&>ds &          
,te*nology1 ! ,environm5tal ,protection 
,ag5cy1 ! ,dep>tm5t ( ,agriculture1 !   
,national ,in/itutes ( ,heal?1 ! ,bureau
 ( ,economic ,analysis1 & any o!r ag5cy 
t ! ,presid5t consid]s appropriate 79   
?is section ref]r$ to z ! int]ag5cy     
committee74 ,! ,director ( ! ,(fice (   
,sci5ce & ,te*nology ,policy %all select
 an additional co-*airp]son f among !   
memb]s ( ! ,int]ag5cy ,committee4 ,!    
,int]ag5cy ,committee %all ov]see !     
plann+1 managem5t1 & coord9ation ( !    
,initiative4 ,! ,int]ag5cy ,committee   
%all-- 7#a7 provide = int]ag5cy         
coord9ation ( ,f$]al eng9e]+ biology    
rese>*1 developm5t1 & o!r activities    
und]tak5 pursuant to ! ,initiative2     
7#b7 e/abli% & p]iodically update goals 
& priorities = ! ,initiative2  7#c7     
develop1 n lat] ?an #ab mon?s aft] !    
date ( enactm5t ( ?is ,act1 & update e  
#c ye>s1 a /rategic plan submitt$ to !  

,committee on ,sci5ce1 ,space1 &        
,te*nology ( ! ,h\se ( ,repres5tatives &
 ! ,committee on ,comm]ce1 ,sci5ce1 &   
,transportation ( ! ,s5ate t-- 7,a7     
guides ! activities ( ! ,initiative =   
purposes ( meet+ ! goals & priorities   
e/abli%$ "u 7& updat$ pursuant to7      
p>agraph 7#b72 &  7,b7 describes-- 7i7 !
 ,initiative's support = long-t]m fund+ 
= int]discipl9>y eng9e]+ biology rese>* 
& developm5t2  7ii7 ! ,initiative's     
support = education & public outrea*    
activities2  7iii7 ! ,initiative's      
support = rese>* & o!r activities on    
e?ical1 legal1 environm5tal1 safety1    
security1 & o!r appropriate societal    
issues relat$ to eng9e]+ biology        
includ+-- 7,i7 an appli$ biorisk        
managem5t rese>* plan2  7,,ii7          
recomm5dations = integrat+ security into
 biological data access & int]national  
reciprocity agreem5ts2 &  7,,iii7 an    
evaluation ( exi/+ biosecurity gov]nance
 policies1 guidance1 & directives = !   
purposes ( creat+ a unifi$1 adaptable1  

evid5ce-bas$ framework to respond to    
em]g+ biosecurity *all5ges creat$ by    
advances 9 eng9e]+ biology2  7iv7 h[ !  
,initiative w move results out ( !      
laboratory & into application = ! b5efit
 ( society & ,unit$ ,/ates              
competitiv5ess2 &  7v7 h[ ! ,initiative 
w measure & track ! contributions (     
eng9e]+ biology to ,unit$ ,/ates        
economic gr[? & o!r societal indicators2
  7#d7 develop a national g5omic sequ5c+
 /rategy to ensure eng9e]+ biology      
rese>* fully lev]ages plant1 animal1 &  
microbe biodiv]sity to enhance long-t]m 
innovation & competitiv5ess 9 eng9e]+   
biology 9 ! ,unit$ ,/ates2  7#e7 propose
 an annually coord9at$ int]ag5cy budget 
= ! ,initiative t is int5d$ to ensure-- 
7,a7 ! ma9t5ance ( a robu/ eng9e]+      
biology rese>* & developm5t portfolio2 &
  7,b7 t ! balance ( fund+ across !     
,initiative is suffici5t to meet ! goals
 & priorities e/abli%$ = ! ,program2    
7#f7 develop a plan to utilize ,f$]al   
programs1 su* z ! ,small ,bus9ess       

,innovation ,rese>* ,program & ! ,small 
,bus9ess ,te*nology ,transf] ,program z 
describ$ 9 section #i ( ! ,small        
,bus9ess ,act 7#ae ,u4,s4,c4 #fch71 9   
support ( ! activities describ$ 9       
section #d7;b77#c72 &  7#g7 9 c>ry+ out 
?is section1 take into consid]ation !   
recomm5dations ( ! advisory committee   
e/abli%$ "u section #f1 ! results ( !   
work%op conv5$ "u section #g1 exi/+     
reports on relat$ topics1 & ! views (   
academic1 ,/ate1 indu/ry1 & o!r         
appropriate gr\ps4  7b7 ,annual report  
,beg9n+ ) fiscal ye> #bjbj1 n lat] ?an  
#ij days aft] submission ( ! ,presid5t's
 annual budget reque/ & ea* fiscal ye>  
!reaft]1 ! int]ag5cy committee %all     
prep>e & submit to ! ,committee on      
,sci5ce1 ,space1 & ,te*nology ( ! ,h\se 
( ,repres5tatives & ! ,committee on     
,comm]ce1 ,sci5ce1 & ,transportation ( !
 ,s5ate a report t includes-- 7#a7 a    
summ>iz$ ag5cy budget 9 support ( !     
,initiative = ! fiscal ye> to :i* su*   
budget reque/ applies1 & = ! !n curr5t  

fiscal ye>1 includ+ a break\t ( sp5d+ = 
ea* ag5cy p>ticipat+ 9 ! ,program & = ! 
developm5t & acquisition ( any rese>*   
facilities & in/rum5tation2 &  7#b7 an  
assessm5t ( h[ ,f$]al ag5cies are       
implem5t+ ! plan describ$ 9 subsection  
7a77#c71 includ+-- 7,a7 a description ( 
! am\nt & numb] ( aw>ds made "u ! ,small
 ,bus9ess ,innovation ,rese>* ,program &
 ! ,small ,bus9ess ,te*nology ,transf]  
,program 7z describ$ 9 section #i ( !   
,small ,bus9ess ,act 7#ae ,u4,s4,c4     
#fch77 9 support ( ! ,initiative2 &     
7,b7 a description ( ! am\nt & numb] (  
projects fund$ "u jo9t solicitations by 
a collaboration ( no few] ?an #b ag5cies
 p>ticipat+ 9 ! ,initiative4  7c7       
,initiative (fice  7#a7 ,9 g5]al ,!     
,presid5t %all e/abli% an ,initiative   
,coord9ation ,(fice1 ) a ,director &    
full-"t /aff1 :i* %all-- 7,a7 provide   
te*nical & adm9i/rative support to !    
int]ag5cy committee & ! advisory        
committee e/abli%$ "u section #f2  7,b7 
s]ve z ! po9t ( contact on ,f$]al       

eng9e]+ biology activities = gov]nm5t   
organizations1 academia1 indu/ry1       
pr(essional societies1 ,/ate gov]nm5ts1 
int]e/$ citiz5 gr\ps1 & o!rs to ex*ange 
te*nical & programmatic in=mation2  7,c7
 ov]see int]ag5cy coord9ation ( !       
,initiative1 includ+ by enc\rag+ &      
support+ jo9t ag5cy solicitation &      
selection ( applications = fund+ (      
activities "u ! ,initiative2  7,d7      
conduct public outrea*1 includ+         
dissem9ation ( f9d+s & recomm5dations ( 
! advisory committee e/abli%$ "u section
 #f1 z appropriate2  7,e7 s]ve z !      
coord9ator ( e?ical1 legal1             
environm5tal1 safety1 security1 & o!r   
appropriate societal input2 &  7,f7     
promote access to1 & e>ly application (1
 ! te*nologies1 innovations1 & exp]tise 
d]iv$ f ,initiative activities to ag5cy 
missions & sy/ems across ! ,f$]al       
,gov]nm5t1 & to ,unit$ ,/ates indu/ry1  
includ+ />tup companies4  7#b7 ,fund+ ,!
 ,director ( ! ,(fice ( ,sci5ce &       
,te*nology ,policy %all develop an      

e/imate ( ! funds necess>y to c>ry out !
 activities ( ! ,initiative ,coord9ation
 ,(fice1 includ+ an e/imate ( h[ mu* ea*
 p>ticipat+ ag5cy describ$ 9 subsection 
7a7 w contribute to su* funds1 & submit 
su* e/imate to ,congress no lat] ?an #ij
 days aft] ! enactm5t ( ?is ,act4  7#c7 
,t]m9ation ,! ,initiative ,coord9ation  
,(fice e/abli%$ "u ?is subsection %all  
t]m9ate on ! date t is #aj ye>s aft] !  
date ( ! enactm5t ( ?is ,act1 unless a  
det]m9ation is made by ! ,presid5t t su*
 ,(fice is necess>y to meet ! economic  
or national security goals ( ! ,program4
  #f4 ,advisory committee  7a7 ,9 g5]al 
,! ,presid5t1 act+ ?r\gh ! ,(fice (     
,sci5ce & ,te*nology ,policy1 %all      
designate or e/abli% an advisory        
committee on eng9e]+ biology rese>* &   
developm5t 79 ?is section ref]r$ to z ! 
advisory committee7 to be compos$ ( n   
few] ?an #ab memb]s1 includ+            
repres5tatives ( rese>* & academic      
in/itutions1 indu/ry1 & nongov]nm5tal   
entities1 :o are qualifi$ to provide    

advice on ! ,initiative4  7b7 ,assessm5t
 ,! advisory committee %all assess--    
7#a7 ! curr5t /ate ( ,unit$ ,/ates      
competitiv5ess 9 eng9e]+ biology1       
includ+ ! scope & scale ( ,unit$ ,/ates 
inve/m5ts 9 eng9e]+ biology rese>* &    
developm5t 9 ! int]national context2    
7#b7 curr5t m>ket b>ri]s to             
comm]cialization ( eng9e]+ biology      
products1 processes1 & tools 9 ! ,unit$ 
,/ates2  7#c7 progress made 9 implem5t+ 
! ,initiative2  7#d7 ! ne$ to revise !  
,initiative2  7#e7 ! balance (          
activities & fund+ across ! ,initiative2
  7#f7 :e!r ! /rategic plan develop$ or 
updat$ by ! int]ag5cy committee e/abli%$
 "u section #e is help+ to ma9ta9 ,unit$
 ,/ates lead]%ip 9 eng9e]+ biology2     
7#g7 ! managem5t1 coord9ation1          
implem5tation1 & activities ( !         
,initiative2 &  7#h7 :e!r e?ical1 legal1
 environm5tal1 safety1 security1 & o!r  
appropriate societal issues are         
adequately address$ by ! ,initiative4   
7c7 ,reports ,beg9n+ n lat] ?an #b ye>s 

aft] ! date ( enactm5t ( ?is ,act1 & n  
less frequ5tly ?an once e #c ye>s       
!reaft]1 ! advisory committee %all      
submit to ! ,presid5t1 ! ,committee on  
,sci5ce1 ,space1 & ,te*nology ( ! ,h\se 
( ,repres5tatives1 & ! ,committee on    
,comm]ce1 ,sci5ce1 & ,transportation ( !
 ,s5ate1 a report on-- 7#a7 ! f9d+s ( ! 
advisory committee's assessm5t "u       
subsection 7b72 &  7#b7 ! advisory      
committee's recomm5dations = ways to    
improve ! ,initiative4  7d7 ,application
 ( ,f$]al ,advisory ,committee ,act     
,section #ad ( ! ,f$]al ,advisory       
,committee ,act 7#e ,u4,s4,c4 ,app47    
%all n apply to ! ,advisory ,committee4 
#g4 ,ext]nal review ( e?ical1 legal1    
environm5tal1 safety1 security1 &       
societal issues  7a7 ,9 g5]al ,n lat]   
?an #f mon?s aft] ! date ( enactm5t (   
?is ,act1 ! ,director ( ! ,national     
,sci5ce ,f\ndation %all seek to ent]    
into an agreem5t ) ! ,national          
,academies ( ,sci5ces1 ,eng9e]+1 &      
,m$ic9e to conduct a review1 & make     

recomm5dations ) respect to1 ! e?ical1  
legal1 environm5tal1 safety1 security1 &
 o!r appropriate societal issues relat$ 
to eng9e]+ biology rese>* & developm5t4 
,! review %all include-- 7#a7 an        
assessm5t ( ! curr5t rese>* on su*      
issues2  7#b7 a description ( ! rese>*  
gaps relat+ to su* issues2  7#c7        
recomm5dations on h[ ! ,initiative c    
address ! rese>* ne$s id5tifi$ pursuant 
to p>agraph 7#b72 &  7#d7 recomm5dations
 on h[ eng9e]+ biology rese>*]s c be/   
incorporate consid]ations ( e?ical1     
legal1 environm5tal1 safety1 security1 &
 o!r societal issues into ! developm5t (
 rese>* proposals & ! conduct ( rese>*4 
7b7 ,report to ,congress ,! agreem5t    
ent]$ into "u subsection 7a7 %all       
require ! ,national ,academies (        
,sci5ces1 ,eng9e]+1 & ,m$ic9e to1 n lat]
 ?an #b ye>s aft] ! date ( ! enactm5t ( 
?is ,act-- 7#a7 submit to ! ,committee  
on ,sci5ce1 ,space1 & ,te*nology ( !    
,h\se ( ,repres5tatives & ! ,committee  
on ,comm]ce1 ,sci5ce1 & ,transportation 

( ! ,s5ate a report conta9+ ! f9d+s &   
recomm5dations ( ! review conduct$ "u   
subsection 7a72 &  7#b7 make a copy (   
su* report available on a publicly      
accessible website4  7c7 ,alt]nate      
contract sci5tific organization  7#a7 ,9
 g5]al ,if ! ,director is unable to ent]
 into an agreem5t describ$ 9 subsection 
7a7 ) ! ,national ,academy ( ,sci5ces   
be=e ! date specifi$ 9 su* subsection on
 t]ms acceptable to ! ,director1 !      
,director %all seek to ent] into su* an 
agreem5t ) ano!r appropriate sci5tific  
organization t-- 7,a7 is n "p ( !       
,gov]nm5t2  7,b7 op]ates z a n-=-pr(it  
entity2 &  7,c7 has exp]tise &          
objectivity comp>able to t ( ! ,national
 ,academy ( ,sci5ces4  7#b7 ,treatm5t   
,if ! ,director ent]s into an agreem5t )
 ano!r organization z describ$ 9        
p>agraph 7#a71 any ref]5ce 9 ?is        
subsection to ! ,national ,academy (    
,sci5ces %all be treat$ z a ref]5ce to !
 o!r organization4  #h4 ,ag5cy          
activities  7a7 ,national ,sci5ce       

,f\ndation ,z "p ( ! ,initiative1 !     
,national ,sci5ce ,f\ndation %all-- 7#a7
 support basic rese>* 9 eng9e]+ biology 
?r\gh individual grants & ?r\gh         
int]discipl9>y rese>* c5t]s2  7#b7      
support rese>* on ! environm5tal1 legal1
 e?ical1 & social implications ( eng9e]+
 biology2  7#c7 provide support = rese>*
 in/rum5tation = eng9e]+ biology        
discipl9es1 includ+ support = rese>*1   
developm5t1 optimization & validation ( 
novel te*nologies to enable ! dynamic   
/udy ( molecul> processes 9 situ2  7#d7 
support curriculum developm5t & rese>*  
exp]i5ces = second>y1 und]graduate1 &   
graduate /ud5ts 9 eng9e]+ biology &     
biomanufactur+2 &  7#e7 aw>d grants1 on 
a competitive basis1 to enable          
in/itutions to support graduate /ud5ts &
 po/doctoral fell[s :o p]=m "s ( _!     
eng9e]+ biology rese>* 9 an indu/ry     
sett+4  7b7 ,dep>tm5t ( ,comm]ce ,z "p (
 ! ,initiative1 ! ,director ( !         
,national ,in/itute ( ,/&>ds &          
,te*nology %all-- 7#a7 e/abli% a        

biosci5ce rese>* program to advance !   
developm5t ( /&>d ref]5ce mat]ials &    
measurem5ts & to create new data tools1 
te*niques1 & processes necess>y to      
advance eng9e]+ biology &               
biomanufactur+2  7#b7 provide access to 
us] facilities ) advanc$ or unique      
equipm5t1 s]vices1 mat]ials1 & o!r      
res\rces to indu/ry1 in/itutions ( high]
 education1 nonpr(it organizations1 &   
gov]nm5t ag5cies to p]=m rese>* & te/+2 
&  7#c7 provide te*nical exp]tise to    
in=m ! pot5tial developm5t ( guidel9es  
or safegu>ds = new products1 processes1 
& sy/ems ( eng9e]+ biology4  7c7        
,dep>tm5t ( ,en]gy ,z "p ( !            
,initiative1 ! ,secret>y ( ,en]gy %all--
 7#a7 conduct & support rese>*1         
developm5t1 demon/ration1 & comm]cial   
application activities 9 eng9e]+        
biology1 includ+ 9 ! areas ( syn!tic    
biology1 advanc$ bi(uel developm5t1     
biobas$ mat]ials1 & environm5tal        
rem$iation2  7#b7 support ! developm5t1 
optimization & validation ( novel1      

scalable tools & te*nologies to enable !
 dynamic /udy ( molecul> processes 9    
situ2 &  7#c7 provide access to us]     
facilities ) advanc$ or unique equipm5t1
 s]vices1 mat]ials1 & o!r res\rces1 z   
appropriate1 to indu/ry1 in/itutions (  
high] education1 nonpr(it organizations1
 & gov]nm5t ag5cies to p]=m rese>* &    
te/+4  7d7 ,dep>tm5t ( ,def5se ,z "p ( !
 ,initiative1 ! ,secret>y ( ,def5se     
%all-- 7#a7 conduct & support rese>* &  
developm5t 9 eng9e]+ biology & associat$
 data & in=mation sci5ces2  7#b7 support
 curriculum developm5t & rese>*         
exp]i5ces 9 eng9e]+ biology & associat$ 
data & in=mation sci5ces across !       
milit>y education sy/em1 to include     
s]vice academies1 pr(essional milit>y   
education1 & milit>y graduate education2
 &  7#c7 assess risks ( pot5tial        
national security & economic security   
?reats relat+ to eng9e]+ biology4  7e7  
,national ,a]onautics & ,space          
,adm9i/ration ,z "p ( ! ,initiative1 !  
,national ,a]onautics & ,space          

,adm9i/ration %all-- 7#a7 conduct &     
support basic & appli$ rese>* 9 eng9e]+ 
biology1 includ+ 9 syn!tic biology1 &   
relat$ to ,e>? & space sci5ces1         
a]onautics1 space te*nology1 & space    
exploration & exp]im5tation1 consi/5t ) 
! priorities e/abli%$ 9 ! ,national     
,academies' decadal surveys2 &  7#b7    
aw>d grants1 on a competitive basis1 t  
enable in/itutions to support graduate  
/ud5ts & po/doctoral fell[s :o p]=m "s (
 _! eng9e]+ biology rese>* 9 an indu/ry 
sett+4  7f7 ,dep>tm5t ( ,agriculture ,z 
"p ( ! ,initiative1 ! ,secret>y (       
,agriculture %all-- 7#a7 support rese>* 
& developm5t 9 eng9e]+ biology1 includ+ 
9 syn!tic biology & biomat]ials2  7#b7  
aw>d grants ?r\gh ! ,national ,in/itute 
( ,food & ,agriculture2 &  7#c7 support 
developm5t conduct$ by ! ,agricultural  
,rese>* ,s]vice4  7g7 ,environm5tal     
,protection ,ag5cy ,z "p ( !            
,initiative1 ! ,environm5tal ,protection
 ,ag5cy %all support rese>* on h[       
products1 processes1 & sy/ems ( eng9e]+ 

biology w affect or c protect !         
environm5t4  7h7 ,dep>tm5t ( heal? &    
human s]vices  7#a7 ,national ,in/itutes
 ( ,heal? ,z "p ( ! ,initiative1 !      
,director ( ! ,national ,in/itutes (    
,heal? %all-- 7,a7 support rese>* &     
developm5t to advance ! und]/&+ &       
application ( eng9e]+ biology = human   
heal?1 includ+ 9 syn!tic biology1 cell &
 tissue eng9e]+1 computational biology1 
& artificial intellig5ce2  7,b7 support 
& accel]ate ! application ( biom$ical   
rese>* & te*nologies ?r\gh              
cross-discipl9>y collaboration & tra9+  
programs2  7,c7 support rese>* on       
e?ical1 legal1 safety1 & societal       
implications ( em]g+ biote*nologies2 &  
7,d7 aw>d grants on a competitive basis1
 t enable in/itutions to support        
graduate /ud5ts & po/doctoral fell[s :o 
p]=m "s ( _! eng9e]+ biology rese>*     
across multiple discipl9>y dep>tm5ts4   
7#b7 ,food & ,drug ,adm9i/ration ,z "p (
 ! ,initiative1 ! ,commission] ( ,food &
 ,drugs %all-- 7,a7 support rese>* &    

evaluation ( safety1 pot5cy1 & efficacy 
( novel biologic products &             
biomanufactur+ te*nologies2 &  7,b7     
ensure ! timely developm5t ( scre5+     
me?ods to evaluate safety & security (  
new biological products & processes4