,i #aad? ,,congress #a/ ,session ,h4 ,r4 #cfff ,,9 ,,! ,,h\se ,,( ,,repres5tatives ,octob] #a1 #bjae ,mr4 ,k+ ( ,new ,york 7= himself1 ,mrs4 ,capps1 ,mr4 ,rangel1 ,ms4 ,norton1 & ,mr4 ,cr[ley7 introduc$ ! foll[+ bill2 :i* 0 ref]r$ to ! ,committee on ,en]gy & ,comm]ce ,a ,,bill ,to coord9ate & advance fibrosis rese>* activities at ! ,national ,in/itutes ( ,heal?1 & = o!r purposes4 #a4 ,%ort title ,?is ,act may be cit$ z ! ,scl]od]ma & ,fibrosis ,rese>* ,enhancem5t ,act ( #bjae4 #b4 ,f9d+s ,congress f9ds z foll[s3 7#a7 ,scl]od]ma1 or sy/emic scl]osis1 is a *ronic & pot5tially fatal rheumatic autoimmune disease ( ! connective tissue4 7#b7 ,ab\t #ajj1jjj ,am]icans h sy/emic scl]osis1 :i* causes fibrosis 7v simil> to sc>r+ :]e excess connective tissue is creat$74 ,! symptoms ( scl]od]ma v>y greatly = ea* p]son1 & ! effects ( scl]od]ma c range f v mild to life-?reat5+4 ,! s]i\sness ( scl]od]ma dep5ds on ! p>ts ( ! body t are affect$ & ! ext5t to :i* !y are affect$4 7#c7 ,ne>ly #de p]c5t ( all dea?s 9 ! develop$ _w are attribut$ to "s type ( *ronic fibroprolif]ative disease4 ,z scl]od]ma impacts multiple organ sy/ems1 sy/emic scl]osis c be consid]$ z a prototypical disease = /udy1 & any insights into its causes are likely to be applicable m broadly to o!r =ms ( organ fibrosis & fibrotic illnesses 7su* z pulmon>y fibrosis & liv] fibrosis74 7#d7 ,v>i\s in/itutes & c5t]s ( ! ,national ,in/itutes ( ,heal? curr5tly support rese>* into =ms ( fibrotic illness1 b !re is little coord9ation & limit$ cross-cutt+ opportunity betwe5 ^! rese>* portfolios4 ,mu* sci5tific progress w be ga9$ by tak+ a broad1 collaborative1 & sy/ematic approa* to /udy+ fibrosis4 #c4 ,national ,commission on ,scl]od]ma & ,fibrosis ,rese>* 7a7 ,e/abli%m5t ,n lat] ?an #a ye> aft] ! date ( enactm5t ( ?is ,act1 ! ,director ( ! ,national ,in/itute ( ,ar?ritis & ,musculoskeletal & ,sk9 ,diseases1 act+ jo9tly ) ! ,director ( ! ,national ,in/itutes ( ,heal?1 %all e/abli% a ,national ,commission on ,scl]od]ma & ,fibrosis ,rese>* 79 ?is section ref]r$ to z ! ,commission7 to develop ! long-t]m plan "u subsection 7b74 7b7 ,long-,t]m plan 7#a7 ,9 g5]al ,n lat] ?an #ah mon?s aft] ! date ( e/abli%m5t ( ! ,commission1 ! ,commission %all develop & submit to ! ,congress a long-t]m plan on opportunities & *all5ges 9 scl]od]ma & fibrosis rese>*4 7#b7 ,recomm5dations on rese>* opportunities ,! plan "u p>agraph 7#a7 %all include recomm5dations on relevant rese>* opportunities ov] ! next decade1 includ+-- 7,a7 a compreh5sive rese>* plan :i* prioritizes fibrosis rese>* opportunities t h cross-cutt+ value & require coord9ation across multiple in/itutes & c5t]s ( ! ,national ,in/itutes ( ,heal?2 7,b7 topic-specific rese>* recomm5dations = ea* organ or sy/em2 & 7,c7 an ov]view ( common !mes & specific /eps = implem5tation ( scl]od]ma & fibrosis rese>*4 7c7 ,work+ gr\ps ,! ,commission %all e/abli% work+ gr\ps-- 7#a7 to consid] ! v>i\s organs & sy/ems impact$ by fibrotic illness2 & 7#b7 to =mulate ! topic-specific rese>* recomm5dations "u subsection 7b77#b77;,b74 7d7 ,memb]%ip ,! ,commission %all be compos$ (-- 7#a7 ! ,director ( ! ,national ,in/itute ( ,ar?ritis & ,musculoskeletal & ,sk9 ,diseases 7or ! ,director's repres5tative72 7#b7 a repres5tative ( ! ,(fice ( ! ,director ( ! ,national ,in/itutes ( ,heal? :o c provide input on program coord9ation across ! in/itutes & c5t]s ( ! ,national ,in/itutes ( ,heal?2 7#c7 /aff f in/itutes & c5t]s ( ! ,national ,in/itutes ( ,heal?1 z det]m9$ appropriate2 & 7#d7 non-,f$]al m$ical exp]ts & pati5t advocates repres5t+ ! v>i\s manife/ations ( scl]od]ma & fibrosis1 z det]m9$ necess>y to =m effective work+ gr\ps "u subsection 7c74 7e7 ,t]m9ation ,! ,commission %all t]m9ate n lat] ?an #b ye>s aft] ! date ( its e/abli%m5t4 #d4 ,scl]od]ma & ,fibrosis ,work+ ,gr\p 7a7 ,e/abli%m5t ,n lat] ?an #ahj days aft] ! developm5t & dissem9ation ( ! long-t]m plan "u section #c7;b71 ! ,director ( ! ,national ,in/itute ( ,ar?ritis & ,musculoskeletal & ,sk9s ,diseases %all create a work+ gr\p1 to be kn[n z ! ,scl]od]ma & ,fibrosis ,work+ ,gr\p 79 ?is section ref]r$ to z ! ,work+ ,gr\p74 7b7 ,responsibilities ,! ,work+ ,gr\p %all-- 7#a7 ov]see & assi/ ) ! implem5tation ( ! recomm5dations & rese>* opportunities id5tifi$ 9 ! long-t]m plan "u section #c7;b72 7#b7 coord9ate ) ! ,(fice ( ! ,director ( ! ,national ,in/itutes ( ,heal? & ! v>i\s in/itutes & c5t]s ( ! ,national ,in/itutes ( ,heal? z appropriate to ov]see & assi/ ) su* implem5tation2 & 7#c7 report1 z ne$$1 to ! advisory c\ncil ( ! ,national ,in/itute ( ,ar?ritis & ,musculoskeletal & ,sk9 ,diseases4 7c7 ,memb]%ip ,! ,work+ ,gr\p %all be compos$ (-- 7#a7 repres5tatives ( ! in/itutes & c5t]s at ! ,national ,in/itutes ( ,heal? ) active or plann$ rese>* projects 9 scl]od]ma or fibrosis1 p>ticul>ly /aff :o are s]v+ or h s]v$ on ! ,national ,commission on ,scl]od]ma & ,fibrosis ,rese>* "u section #c2 & 7#b7 pati5t advocates & extramural rese>*]s :o c provide mean+ful input on ! recomm5dations & rese>* opportunities id5tifi$ 9 ! long-range plan "u section #c7;b71 p>ticul>ly individuals :o are s]v+ or h s]v$ on ! ,national ,commission on ,scl]od]ma & ,fibrosis ,rese>* "u section #c4 7d7 ,meet+s ,! ,director ( ! ,national ,in/itute ( ,ar?ritis & ,musculoskeletal & ,sk9 ,diseases %all conv5e ! ,work+ ,gr\p = a meet+ at lea/ #c times ea* ye>4 #e4 ,report to ,congress ,n lat] ?an #b ye>s aft] ! date ( e/abli%m5t ( ! ,national ,commission on ,scl]od]ma & ,fibrosis ,rese>* "u section #c1 ! ,director ( ! ,national ,in/itute ( ,ar?ritis & ,musculoskeletal & ,sk9 ,diseases %all submit to ! ,congress a report on implem5tation ( ! long-range plan "u section #c7;b74