,i #aacth ,,congress #ast ,session ,h4 ,r4 #aeae ,,in ,,the ,,house ,,of ,,representatives ,april #aa1 #bjac ,mr4 ,sires 7for himself and ,mr4 ,diaz-,balart7 introduced the following bill2 which was referred to the ,committee on ,foreign ,affairs ,a ,,bill ,to amend the ,foreign ,assistance ,act of #aifa to codify the cooperative agreement1 known as the ,health ,technologies program1 under which the ,united ,states ,agency for ,international ,development supports the development of technologies for global health1 and for other purposes4 #a4 ,short title ,this ,act may be cited as the #bast ,century ,global ,health ,technology ,act4 #b4 ,findings ,congress makes the following findings3 7#a7 ,research and development is a critical component of ,united ,states leadership in global health4 ,research and innovation can help to break the cycle of aid dependency by providing sustainable solutions to long-term problems4 ,research and development for global health is crucial for meeting new and emerging challenges1 creating efficiencies1 strengthening health systems1 shifting tasks and strengthening workforces1 and increasing access to health services for the most vulnerable4 ,research suggests that advances in health and medical technologies have been the major drivers behind massive improvements in health worldwide over the past century1 resulting in an average increase in life expectancies of #ba years in low- and middle-income countries between #aifj and #bjjb4 ,additionally1 new health technologies have a high return on investment4 ,for example1 it is estimated that a new meningitis ,a vaccine developed in collaboration with the ,united ,states ,agency for ,international ,development 7,,usaid71 the ,centers for ,disease ,control and ,prevention 7,,cdc71 the ,national ,institutes of ,health 7,,nih71 and the ,food and ,drug ,administration 7,,fda71 will save #egj1jjj1jjj over the next decade in costs that would otherwise be incurred for emergency vaccination campaigns1 freeing much needed resources for use elsewhere in overstretched health systems4 7#b7 ,five ,federal agencies--,,nih1 ,,usaid1 the ,department of ,defense1 ,,cdc1 and ,,fda--provide significant contributions each year to global health research and development4 ,the ,united ,states ,government is supporting the development of #bjj--ee percent--of the #cfe products in the global pipeline of products for neglected and poverty-related diseases4 7#c7 ,this commitment from the ,united ,states ,government and its ,federal agencies has led to a remarkable increase in global health products4 ,forty-five new health tools were registered between #bjjj and #bjaj1 and the ,united ,states ,government was involved in #bd1 or #ec percent1 of these new global health products in the last decade including #f drugs for malaria1 #b vaccines for pneumonia1 #f diagnostics for tuberculosis1 and #b drugs for leishmaniasis4 7#d7 ,united ,states investments have enabled tremendous progress in the introduction of new technologies for global health2 however1 gaps exist in bringing certain technologies through the development process and rapidly scaling them up in the field4 ,better coordination is needed between ,federal agencies to align research strategies1 identify and address gaps in product development activity and move products efficiently along the research-to-introduction continuum4 7#e7 ,infectious diseases disproportionately impact populations in low-income nations across ,latin ,america1 sub-,saharan ,africa1 and ,asia4 ,however1 even in the ,united ,states1 poor and vulnerable communities are at much greater risk for contracting diseases usually considered to be diseases of the developing world4 ,for example1 cases of ,chagas disease1 which is found throughout ,latin ,america1 and dengue fever1 endemic to ,mexico and ,central ,america1 have been detected in southern ,states along the ,united ,states border with ,mexico1 in communities where poverty rates are high4 7#f7 ,in collaboration with the ,world ,health ,organization 7,,who7 and its member states1 the ,united ,states is a leading participant in discussions to improve coordination and financing of global health research and development4 ,this process will establish mechanisms to map research needs1 identify resource gaps1 and set priorities to ensure that the most crucial global health products are developed and delivered for maximum global health impact4 7#g7 ,because of its presence in the field1 ,,usaid is uniquely placed to assess local health conditions1 then partner with public and private stakeholders to ensure the development and timely introduction and scale-up of tools that are culturally acceptable1 address serious and all-too-common health problems1 and contribute to the strengthening of health systems4 ,in a recent report to ,congress1 ,,usaid calls health research integral to its ability to achieve its health and development objectives worldwide and states that innovation through research allows the agency to develop and introduce affordable health products and practices and contribute to policies appropriate for addressing health-related concerns in the developing world4 ,the elevation of the ,office of ,science and ,technology would assist ,,usaid in achieving its global health and development goals4 ,in #bjaa1 ,,usaid outlined a #e-year health research strategy3 ,report to ,congress3 ,health-,related ,research and ,development ,activities at ,,usaid 7,,hrrd71 ,may #bjaa1 with a timeline through #bjaj4 ,this strategy is an important source of information on ,,usaid's programs for global health product development and is an effective tool for measuring expected results from #bjaa through #bjae4 ,the strategy does not articulate ,,usaid's investments and programming for research and development in several critical areas such as-- 7,a7 new tools to diagnose1 prevent and treat neglected tropical diseases2 7,b7 biomedical products1 technologies and devices for conditions and diseases impacting maternal health1 newborns1 and children1 including research for vaccines for the leading causes of death in children2 and 7,c7 new tuberculosis vaccines4 7#h7 ,congress notes the interrelated initiatives that ,,usaid has taken to advance science1 technology1 and innovation for development1 including the ,grand ,development ,challenges1 the ,innovation ,fund1 ,higher ,education ,science ,network1 the ,development ,lab1 and the ,innovation ,fellowship4 7#i7 ,research and development at ,,usaid-- 7,a7 facilitates public-private collaboration in the development of global health technologies2 7,b7 leverages public and private sector support for early stage research and development of health technologies to encourage private sector investment in late-stage technology development and product introduction in developing countries2 7,c7 benefits the ,united ,states economy by investing in the growing ,united ,states global health technology sector1 which-- 7i7 provides skilled jobs for ,american workers for example1 #fd cents of every ,united ,states dollar invested in global health research benefits ,united ,states-based researchers2 7ii7 creates opportunities for ,united ,states businesses in the development and production of new technologies2 and 7iii7 enhances ,united ,states competitiveness in the increasingly technological and knowledge-based global economy2 and 7,d7 enhances ,united ,states national security by-- 7i7 reducing the risk of pandemic disease2 and 7ii7 contributing to economic development and stability in developing countries4 7#aj7 ,investments by the ,united ,states in affordable1 appropriate health technologies1 such as medical devices for maternal1 newborn1 and child care2 new vaccines2 new vaccine technologies and delivery tools2 safe injection devices2 diagnostic tests for infectious diseases2 new tools for water1 sanitation1 and nutrition2 multipurpose prevention technologies2 information systems and mobile health and information systems2 and innovative disease prevention strategies-- 7,a7 reduce the risk of disease transmission2 7,b7 accelerate access to life-saving global health interventions for the world's poor2 7,c7 reduce the burden on local health systems2 and 7,d7 have been found by the ,united ,states ,government and ,,who to result in significant cost savings for development assistance funds4 7#aa7 ,where markets fail1 public-private partnerships are an effective way to develop1 introduce and scale up new health technologies4 ,product development partnerships 7,p,d,ps7 are one model of public private partnership that is successfully accelerating research to benefit the developing world4 ,p,d,ps are non-profit1 nongovernmental entities that work to accelerate the development of new tools to fight diseases in resource-poor settings4 ,typically1 ,p,d,ps manage resources and partnerships from across public1 private1 and philanthropic sectors to drive the development of a full pipeline of potential new products that could save and improve lives in the developing world4 ,,usaid has played a significant role in advancing the ,,pdp model through its financial support4 ,over the past decade1 the achievements of ,p,d,ps have become increasingly successful at advancing new products through the development pipeline towards registration1 product introduction1 and use4 7#ab7 ,,usaid supports research and introduction activities along a research-to-use continuum including-- 7,a7 evidence reviews and health assessments in developing countries2 and 7,b7 the development1 testing1 adaptation1 and introduction of appropriate products and interventions within the context of strengthening health systems4 7#ac7 ,a ,center for ,accelerating ,innovation and ,impact has been established at ,,usaid to address technical1 supply and policy barriers in the development1 introduction and scale-up of new products and technologies for global health4 ,for diseases and conditions where market forces have proven insufficient to generate and rapidly deliver new technologies1 the ,center promotes and reinforces solutions to overcome obstacles such as regulatory inefficiencies in developing countries1 limited user demand1 gaps in market data and supply chain hurdles4 ,the ,center also catalyzes partnerships with the public and private sectors to develop and rapidly deploy new products4 7#ad7 ,through a cooperative agreement1 known as the ,health ,technologies program1 ,,usaid supports the development of technologies that-- 7,a7 maximize the limited resources available for global health2 and 7,b7 ensure that products and medicines developed for use in low-resource settings reach the people that need such products and medicines4 ,through the ,health ,technologies program1 #he technologies have been invented1 designed1 developed or co-developed and more than #ajj private-sector collaborators have been involved in the ,health ,technologies program1 matching ,,usaid dollars at least two to one4 ,over its #be-year history1 more than #ie private-sector collaborators have been involved in the ,health ,technologies program1 matching ,,usaid dollars two to one4 7#ae7 ,,usaid's research and development is complementary to the work of other agencies4 #c4 ,purposes ,the purpose of this ,act is to acknowledge ,,usaid's role in product development1 introduction and scale-up of new global health tools and authorize ,,usaid's ,health ,technologies program1 in effect as of the date of the enactment of this ,act1 under which the ,united ,states ,agency for ,international ,development supports the development of technologies for global health to-- 7#a7 improve global health2 7#b7 reduce maternal1 newborn1 and child mortality rates2 7#c7 reverse the incidence of ,,hiv_/,,aids1 malaria1 tuberculosis1 and other infectious diseases2 7#d7 reduce the burden of chronic diseases2 7#e7 overcome technical1 supply and policy hurdles to product introduction and scale-up2 and 7#f7 support research and development that is consistent with a global development strategy and other related strategies developed by ,,usaid4 #d4 ,codification of ,health ,technologies program ,section #ajg of the ,foreign ,assistance ,act of #aifa 7#bb ,u4,s4,c4 #baea;e7 is amended by adding at the end the following3 7c7 ,health technologies program 7#a7 ,there is established in the ,united ,states ,agency for ,international ,development 7,,usaid7 a health technologies program 7referred to in this subsection as the program74 7#b7 ,the program shall develop1 advance1 and introduce affordable1 available1 and appropriate and primarily late-stage technologies specifically designed to-- 7,a7 improve the health and nutrition of populations in developing countries2 7,b7 reduce maternal1 newborn1 and child mortality in such countries2 and 7,c7 improve the diagnosis1 prevention1 and reduction of disease1 especially ,,hiv_/,,aids1 malaria1 tuberculosis1 and other infectious diseases1 in such countries4 7#c7 ,the program shall be carried out under a cooperative agreement between ,,usaid and one or more institutions with a successful record of-- 7,a7 advancing the technologies described in paragraph 7#b72 and 7,b7 integrating practical field experience into the research and development process in order to introduce the most appropriate technologies4 7#d7 ,the provisions of this subsection codify the cooperative agreement1 known as the ,health ,technologies program1 in effect as of the date of the enactment of this subsection1 under which ,,usaid supports the development of technologies for global health4 ,the provisions of this subsection do not establish a new cooperative agreement or program for such purposes4 7d7 ,action plans ,the ,administrator of the ,united ,states ,agency for ,international ,development 7,,usaid7 shall establish and implement action plans to incorporate global health research and product development within each of the global health and development programs1 with support from coordinating agencies1 and shall establish metrics to measure progress4 ,in implementing the action plans1 the ,administrator shall consider all options1 including the use of public private partnerships4 7e7 ,priority global health interventions ,the ,center for ,accelerating ,innovation and ,impact of the ,united ,states ,agency for ,international ,development shall continue its work to speed the development1 introduction1 and scale-up of priority global health interventions4 4 #e4 ,report on research and development activities at ,,usaid 7a7 ,in general ,the ,administrator of the ,united ,states ,agency for ,international ,development 7referred to in this section as ,,usaid7 shall submit to ,congress an annual report on research and development activities at ,,usaid4 7b7 ,matters ,to be included ,the report required by subsection 7b7 shall describe-- 7#a7 updates on the implementation of its strategy for using research funds to stimulate the development and introduction of products in each of its global health and development programs2 7#b7 ,,usaid's collaborations and coordination with other ,federal departments and agencies in support of translational and applied global health research and development2 7#c7 its investments for the fiscal year in science1 technology1 and innovation2 7#d7 how these technologies and research products complement the work being done by other ,federal departments and agencies1 if applicable2 and 7#e7 technologies and research products that have been introduced into field trials or use4 7c7 ,consultation ,the ,administrator of ,,usaid shall consult on an annual basis with the heads of other ,federal departments and agencies to improve alignment of ,,usaid's health-related research strategy with other similar agency strategies1 with the intent of working towards a whole-of-government strategy for global health research and development4