,,! ,,am]ican ,,j\rnal ,,( ,,ph>macy ,,m>*1 #aijg4 ,,/&>ds ,,9 ,,ph>maceutical ,,education4#a ,,by ,,h5ry ,,kraem]4 ,if we consid] ! pres5t awak5+ 9 ph>macy1 x may seem to "s t we are mak+ v rapid /rides1 b z a matt] ( fact ! progress ( ph>maceutical education 9 ?is c\ntry has be5 comp>atively sl[4 ,! hi/ory ( ph>macy 9 ?is c\ntry may be divid$ into ?ree p]iods3 7#a7 ,! pione] p]iod dur+ ! sixte5? c5tury1 :5 !re 7 no physicians1 & ! g5]al /orekeep] :o sold dry goods1 groc]ies1 books & pa9ts1 also sold m$ic9es & prescrib$ !m2 7#b7 ! colonial p]iod dur+ ! sev5te5? & eighte5? c5turies1 :5 educat$ physicians f abroad emigrat$ to ! colonies & prescrib$ z well z disp5s$ m$ic9es2 7#c7 ! college p]iod1 or ! p]iod ( organization & developm5t1 dur+ ! n9ete5? c5tury1 :5 ph>macy became a di/9ct pr(ession & bus9ess1 & colleges ( ph>macy 7 e/abli%$1 ^! numb]+ ne>ly #ajj at ! pres5t "t4 ,we are n[ ent]+1 aft] ne>ly a c5tury1 ^u ! f\r? p]iod1 namely1 t ( /&>ds 9 education1 & we are endeavor+ to fix ! position ( ph>macy among ! o!r pr(essions4 ,! problem ( ph>maceutical education involves two phases1 namely 7#a7 t ( ! natural ability & prelim9>y qualifications ( ! applicants = entrance to ! colleges & s*ools ( ph>macy1 & 7#b7 t ( ! "* & k9d ( in/ruction t %all be giv5 by a recogniz$ tea*+ in/itution 9 ph>macy4 ,n only are ^! two classes ( /&>ds be+ consid]$ by ! tea*+ bodies !mselves1 b also by ! bo>ds ( ph>macy1 & ) ! enactm5t ( laws 9 v>i\s ,/ates x w n[ be possible = m or less conc]t$ action to be tak5 ?r\gh\t ! ,unit$ ,/ates4 ,,prelim9>y ,,requirem5ts4 ,our sy/em ( popul> education is ! boa/ ( our c\ntry1 & well may x be1 = x has be5 mak+ /eady advances dur+ all ! ye>s ( our national exi/5ce4 ,at ! pres5t "t ! facilities = in/ruction & ! opportunities = obta9+ a good g5]al education are s ample t x seems h>dly cr$ible t any "o :o is desir\s ( obta9+ an education %\ld fail 9 ! attempt4 ,x foll[s logically t z ! /&>d ( g5]al education is advanc$1 ! /&>ds 9 colleges1 te*nical s*ools & univ]sities w also be advanc$1 & ?us we f9d to-day t ! majority ( ^! in/itutions are n only con/antly improv+ _! curricula b !y are see+ to x t ^? :o g to !m = in/ruction are qualifi$ to pursue ! prescrib$ l9e ( /udies4 ,! only wond] is t ! entrance /&>ds 9 "s ( ! pr(essional s*ools h n be5 advanc$ m rapidly ?an !y h1 = 9 no o!r way h !y be5 m h&icapp$ ?an 9 ?is4 ,x is true !re may be "s p>ts ( our c\ntry :]e ! opportunities = obta9+ an education are m or less limit$1 b ?is is no argum5t :y ^? 9 ! vangu>d %\ld /op 9 _! c\rse & wait = ! c5t] ( population to %ift a few hundr$ miles4 ,we "k t 9 ,alaska & ! ,philipp9es ! means = education are n s ample z !y are ) u1 b we are n ?9k+ ( /opp+ to wait = ^? c\ntries4 ,on ! contr>y !y desire u to g ahead & !y w foll[ z rapidly z possible4 ,& s if ! y\?s ( ! c\ntry di/ricts ( ,i[a1 or ,kansas1 or ,miss\ri h n1 z is claim$ by "s1 ! opportunity = obta9+ a high s*ool education1 is t any reason :y ^? 9 ,ohio1 or ,mi*igan1 or ,p5nsylvania %\ld be excus$ = neglect+ !irs8 ,no1 ?is is n ! way ( progress4 ,if !re are any two pr(essions or call+s :]e ! unfit %\ld be cull$ out m ?an 9 o!rs1 x is 9 ^? ( m$ic9e & ph>macy4 ,^! are ! pr(essions call+ = ! highe/ type ( manhood1 & at ! same "t special educational equipm5t & intellectual acum54 ,be+ l>gely answ]able to himself 9 ! conduct ( 8 bus9ess1 x is pla9 t ! ph>maci/ mu/ be ( a high moral type1 & if he is ( ! type t he %\ld be to assume su* a responsible call+1 he w fir/ see to x t 8 g5]al education w>rants him 9 und]tak+ its pursuit4 ,b if !re are ^? :o h n ! moral s5se to consci5ti\sly qualify !mselves by obta9+ ! necess>y prelim9>y education1 !n ! tea*+ bodies %\ld ex]cise _! p[] to elim9ate !m4 ,"h is :]e ! highe/ obligation ( ! s*ools & colleges ( ph>macy re/s1 & "h is :]e ! supreme te/ ( _! s5se ( _! obligation to ! public comes 94 ,c]ta9ly ^? applicants = entrance :o h _h opportunities = obta9+ an education & h be5 s indiff]5t z n to improve !m1 c h>dly be consid]$ fit c&idates = ! practice ( ph>macy4 ,entrance to a college presupposes a good g5]al education2 ! /udies to be ma/]$ require x1 & to admit ! unqualifi$ reacts on all ^? engag$ 9 ! practice ( ph>macy & 9 ! tea*+ ( ph>macy4 ,x also does h>m to ^? :o are /ill 9 ! public s*ools1 = in/ead ( f9i%+ _! c\rses !y discont9ue _! /udies kn[+ t !y c fit !mselves by %ort cuts4 ,x l[]s ! /&>d ( ! s*ools ( ph>macy & s t5ds to keep away ^? :o are qualifi$ to pursue ! "w4 ,9 %ort1 x l[]s ! tone ( ph>macy at e po9t4 ,& :o c say t x does n ev5tually make an impression on ! g5]al public & influ5ce !m 9 )hold+ _! support1 bo? moral & f9ancial8 ,i "k ( a "y man :o desir$ to /udy law1 b :o _h n gone fur!r ?an ! gramm> s*ool4 ,:5 he came to inquire ab\t ! t]ms ( admission to ! b>1 he f\nd t graduation f a high s*ool 0 requir$4 ,he !n decid$ to ent] s*ool aga9 & g ?r\gh ! high s*ool4 ,c any "o d\bt ! advantage ( su* a c\rse to ?is "y man or to ! pr(ession ( law 9 requir+ him to complete 8 prelim9>y education8 ,!re are ^? :o incl9e to take pity on ^? applicants 9 ph>macy :o h n ! desir$ am\nt ( prelim9>y education & :o argue t !y %\ld be giv5 a *ance4 ,b ?is is a false k9d ( *>ity2 if ! applicants are s9c]e & h natural ability1 !y %\ld be advis$ to g back to s*ool1 b if !y belong to ! %iftless class1 !y %\ld above all ?+s n be all[$ to ally !mselves ) ph>macy4 ,no1 ?is is n ! place = ! ex]cise ( *>ity1 p>ticul>ly :5 we ?9k ( our obligations to ! great public :o h s long & s implicitly tru/$ u4 ,,college ,,c\rses4 ,hav+ once elim9at$ ! unfit1 ! next highe/ duty ( ! colleges ( ph>macy is to qualify _! /ud5ts = ! "w t !y may be call$ ^u to d4 ,?is may seem l a v trite say+ to "s ( y1 & yet ,i feel w>rant$ 9 its utt]ance4 ,we h rea*$ a crisis 9 ph>maceutical hi/ory1 & if ! ph>maci/ is to cont9ue a sep>ate & indep5d5t exi/5ce x mu/ be on ! basis ( 8 sci5tific atta9m5ts4 ,! ph>maci/ has felt 8 hamp]$ position = "s "t1 b n[ t ! ,pure ,food & ,drugs ,act has become effective1 we are face to face ) ! issue4 ,) ! ,unit$ ,/ates ,ph>macopia & ! ,national ,=mul>y z ! legal /&>ds he w n[ be held responsible = ! id5tity & quality ( ! drugs :i* he sells4 ,! "q !n is1 w he assume ?is responsibility1 & pron\nce f9ally on ! quality & effici5cy ( ! drugs & m$ic9es :i* he disp5ses1 or w he %ift ?is responsibility :5ev] possible8 ,if he adopts ! latt] c\rse1 !n w he lose 9 importance & /&+ to t ext5t4 ,by ! adoption ( ! ,pure ,food & ,drugs ,act bo? ! responsibility & ! obligation ( ! ph>maci/ are increas$ & add$ importance mu/ atta* to 8 position4 ,he %\ld take z mu* pride 9 8 ability to pron\nce ^u ! quality ( an article gu>ante$ by ! manufactur]1 or 9 mak+ a prep>ation :i* he himself gu>antees1 z he has h]et(ore tak5 9 8 ability to decide ^u ! compatibility1 or to "q ! dosage1 ( a prescription4 ,he mu/ /& betwe5 ! manufactur] & ! physician z he has /ood betwe5 ! physician & ! public4 ,too mu* c>e _c be ex]cis$ 9 ?is direction1 = ! manufactur]'s gu>antee may 9 "s in/ances prove to be only a label4 ,to d "w ( ?is k9d means t ! ph>maci/ %all be a ma/] ( ! ,ph>macopia1 t he %all be able to id5tify any sub/ance 9 ! ,ph>macopia1 c>ry out any ( ! te/s1 & make any ( ! prep>ations 9 ! ,ph>macopia & ,national ,=mul>y1 processes = :i* are giv54 ,! lea/1 !n1 t ! colleges ( ph>macy c d is to prep>e _! /ud5ts to employ ! ,ph>macopia & ! ,national ,=mul>y z work+ guides4 ,,exam9ations ,,by ,,bo>ds ,,( ,,ph>macy4 ,) ! prop] prelim9>y requirem5ts e/abli%$1 & )\t ent]+ at ?is "t into a discussion ( ! "q z to ! numb] ( h\rs requir$ = ! "w t %\ld be done1 believ+ z ,i d t ! colleges & s*ools belong+ to ! ,conf]5ce ( ,tea*+ ,faculties w be able to decide ?is problem1 ,i may say t no discussion ( ! educational problem is complete at ?is "t )\t ref]5ce to ! nature ( ! exam9ations ( ! ,bo>ds ( ,ph>macy4 ,9 ye>s gone by ^! exam9ations h be5 l>gely !oretical1 & h5ce 7 n s valuable z !y might h be5 9 te/+ ! fitness ( a c&idate4 ,happily1 !re is beg9n+ to be an improvem5t 9 ?is direction & ! exam9ations are becom+ m practical4 ,to my way ( ?9k+ ! aim ( ! bo>ds ( ph>macy %\ld be to det]m9e :at a c&idate c d4 ,! !ory has be5 giv5 to him 9 college1 & ! f9al te/ %\ld be to det]m9e :e!r he has a work+ k ( ! mat]ials :i* he h&les4 ,in/ead ( ask+ him :at are ! elem5t>y =ms ( matt]1 or :at is a wat]-ba?1 or to give ! family "n ( a plant yield+ a drug1 x w\ld be bett] to give him "s drug or *emical to id5tify1 to c>ry out ! te/s = purity accord+ to ! ,ph>macopia & to make a prep>ation4 ,! bo>ds ( ph>macy h a v important "w to p]=m 9 det]m9+ ! fitness ( c&idates & 9 det]m9+ :e!r ! colleges are fai?fully c>ry+ on _! "w4 ,z matt]s are n[ con/itut$ !y are ! f9al arbit]s & %\ld be fully cognizant ( ! great tru/ :i* !y hold4 ,x %\ld no long] be possible = ! unqualifi$ or incompet5t to ent] college1 sp5d two or ?ree ye>s at college & be giv5 a degree & f9ally pass a ,/ate ,bo>d z a regi/]$ ph>maci/4 ,,! ,,duty ,,( ,,ph>maci/s4 ,ph>maci/s !mselves also h a v important "p to p]=m 9 rais+ ph>macy to ! plane t x mu/ occupy to ma9ta9 its sep>ate exi/5ce4 ,9 ! fir/ place !y %\ld n admit into appr5tice%ip "y m5 :o are defici5t 9 prelim9>y education1 = q naturally !y hope soon] or lat] to ent] ! s*ools ( ph>macy4 ,inde$ to admit su* z ^! into appr5tice%ip is n only an inju/ice to !m b also to ! colleges ( ph>macy1 & ?is may be consid]$ z "o ( ! fundam5tal te/s z to :e!r ! ph>maci/ has ! true int]e/s ( 8 call+ at he>t4 ,ph>maci/s c at ?is po9t be ( real s]vice to ^! "y m5 by enc\rag+ !m & advis+ !m to cont9ue _! education 9 ! public s*ools or to acquire x 9 "s o!r way4 ,! second duty ( ! ph>maci/ is to endeavor to conduct 8 bus9ess 9 su* a mann] t ! educat$ "y m5 w be attract$ to x 7= und\bt$ly !re is no m int]e/+ "w ?an t connect$ ) ! pr(ession ( ph>macy71 & f9d some?+ to repay !m = _! pa9s1 & to appeal to _! aspirations z pr(essional m54 ,! ?ird duty ( ! ph>maci/ is to ! physician4 ,if ! physician is will+ to rely ^u ! ph>maci/ & to help him 9 ma9ta9+ & re-e/abli%+ ! pr(ession ( ph>macy by prescrib+ only ! prep>ations & m$ic9es 9 ! ,ph>macopia & ,national ,=mul>y1 & ! new & non-(ficial rem$ies approv$ by ! ,c\ncil on ,ph>macy & ,*emi/ry ( ! ,am]ican ,m$ical ,association1 !n %\ld ! ph>maci/ aim to elim9ate z rapidly z possible pat5t m$ic9es1 no/rums & sundry articles n us$ z m$ic9es1 or z aids to ! sick1 or ev5 z toilet prep>ations1 & prep>e to give 8 undivid$ att5tion to 8 pr(ession1 :i* alone by tra9+1 education & exp]i5ce he is qualifi$ to conduct4 ,9 briefly summ+ up my rem>ks ,i may say t ,i h endeavor$ to emphasize ! ess5tial pr9ciples :i* we mu/ be> 9 m9d4 7#a7 ,a good prelim9>y education is ess5tial to an appr5tice & /ud5t ( ph>macy4 7#b7 ,! lea/ t a college or s*ool ( ph>macy %\ld d is to s5d =? graduates t are ma/]s ( e detail ( ! ,u4 ,s4 ,ph>macopia & ! ,national ,=mul>y4 7#c7 ,x is ! duty ( ! ,bo>d ( ,ph>macy to det]m9e :at applicants = ! c]tificate ( ,regi/]$ ,ph>maci/ c d r ?an :at !y are able to memorize4 7#d7 ,t ph>maci/s !mselves mu/ %>e 9 ! "w ( elevat+ ! /&>ds ( ph>macy4 ,if we are cle> on ^! pr9ciples1 s9c]e 9 our pr(essions & e>ne/ 9 our endeavors1 ! details c easily be work$ out4 ,,! ,,food ,,& ,,drugs ,,act ,,9 ,,its ,,relation ,,to ,,public ,,heal?4 ,,by ,,*>les ,h4 ,,lawall4 ,! responsibility ( ! ph>maci/ 9 8 attitude t[>d fraud & quack]y 0 nev] m important ?an x is at ! pres5t "t1 & !re %\ld be no reluctance on ! "p ( ! memb]s ( ! pr(ession to s]ve ! public 9 ! capacity ( dissem9ators ( in=mation conc]n+ ?is important subject :i* is ev]y:]e "u discussion1 ! ,food & ,drugs ,act4 ,9 ! ,unit$ ,/ates ! actual control ( ! quality ( food & drugs )9 any giv5 ,/ate is a p[] ( ! ,/ate & n ( ! f$]al au?ority1 & ow+ to ! previ\s abs5ce ( legislation controll+ int]/ate comm]ce ! au?orities )9 ! individual ,/ates 7usually ! ,dairy & ,food ,commission]7 7 conf9$ to ! b\nd>ies ( ^! ,/ates 9 br++ prosecutions4 ,9 ord] to control ! sale ( products made outside ( ! ,/ate & %ipp$ into x1 ! sell]1 (t5 an innoc5t victim1 _h to be proce$$ aga9/1 & ! manufactur]1 ! real (f5d]1 0 secure f any puni%m5t z long z he rema9$ )\t ! ,/ate4 ,?is condition ( affairs1 ( c\rse1 work$ h>d%ip ^u p]sons :o 7 n morally responsible1 :o 7 made def5dants 9 crim9al prosecutions & 7 compell$ to resort to ! civil c\rts = r$ress1 :i* 0 usually inadequate4 ,on ,june #cj1 #aijf1 by ! passage ( ! act kn[n z ! ,food & ,drugs ,act1 :i* w5t into effect legally on ,janu>y #a1 #aijg1 ?is condition ( affairs 0 *ang$1 & e article ( int]/ate comm]ce is n[ subject to ! act1 ! rules & regulations ( :i* h occasion$ mu* s]i\s ?\ght among ! l>ge class ( manufactur]s ( products :i* come )9 its scope4 ,! und]ly+ pr9ciples ( ! act1 & ! rules & regulations :i* h be5 draft$ = its en=cem5t1 are n obscure4 ,!y are bas$ ^u common hone/y4 ,t is1 no h>d%ip is work$ ^u p]sons :o sell _! products = :at !y are1 )\t any misrepres5tation4 ,?is at fir/ glance w\ld n seem to be a h>% requirem5t1 b :5 we g into ! subject a little m fully we are confront$ ) ! fact t ! pres5t era ( adv]tis+ has develop$ a c>elessness ( /atem5t to say no?+ ( num]\s in/ances ( wilful misrepres5tation sugge/+ t ! allegation ( ,p4 ,t4 ,b>num t ! ,am]ican p l to be humbugg$1 0 nev] m true ?an at ! pres5t "t4 ,academic que/ions z to ! h>mfulness ( c]ta9 pres]vatives or colors1 or sub/itutes = ?is or t well-kn[n food/uff1 d n ent] into ! "q at all4 ,! phrase 8caveat emptor10 let ! buy] bew>e1 is n applicable to food/uffs1 = ! buy] z a rule is n capable ( judg+ z to ! pres5ce or abs5ce ( c]ta9 con/itu5ts :i* may or may n be h>mful accord+ to ! idiosyncrasy ( ! consum]4 ,= example1 fifty or sev5ty-five ye>s ago ! commonly us$ *emical pres]vatives1 salicylic & b5zoic acids & sac*>9 7 unkn[n & :5 !y 7 resort$ to by manufactur]s ( food/uffs x 0 done secretly & )\t notice to ! consum]4 ,:ile ! pres5ce ( a small am\nt ( any "o ( ^! sub/ances might n occasion any di/urbance 9 a normal individual !re are _m in/ances 9 :i* ev5 small am\nts are absolutely contra9dicat$4 ,"u comm]cial conditions exi/+ previ\s to ! passage ( ! act m5tion$ ! buy] nev] c\ld tell j :at 0 conta9$ 9 a package1 :i* might be m>k$ absolutely pure & be decorat$ ) repres5tations ( doz5s ( m$als & prize aw>ds1 (t5 bas$ ^u sup]ficial judgm5t ( ! products s honor$4 ,! misbr&+ clause is ,section #h ( ! law & reads z foll[s3 8,t ! t]m #8misbr&$' z us$ h]e9 %all apply to all drugs or articles ( food1 or articles :i* ent] into ! composition ( food1 ! package or label ( :i* %all be> any /atem5t1 design or device reg>d+ su* article1 or ! +r$i5ts or sub/ances conta9$ !re91 :i* %all be false or mislead+ 9 any p>ticul> & to any food or drug product :i* is falsely br&$ z to ! ,/ate1 t]ritory or c\ntry 9 :i* x is manufactur$ or produc$40 ,s9ce ! act has become effective ! products ( c]ta9 l>ge pack+ h\ses1 :i* 7 =m]ly call$ pott$ ham or pott$ tongue are n[ label$ 8pott$ meat1 ham-flavor0 & 8pott$ meat1 tongue-flavor40 ,! sub/ance has n be5 *ang$4 ,x is simply designat$ by its "r "n & all ! claims = purity made by ^! firms 9 ! pa/ are n[ to be judg$ by ! actions ( ^! same firms :5 "u compulsion & 9 fe> ( ! law4 ,sev]al ye>s ago a well-kn[n ,philadelphian became sponsor = a br& ( c(fee :i* 0 adv]tis$ & sold "u ! caption ( 8tann9-free c(fee40 ,?is purport$ to be c(fee f :i* ! poison\s 787 tannic acid _h be5 remov$4 ,inve/igation %[$ x to be c(fee f :i* a *aff-l sub/ance ly+ betwe5 ! segm5ts ( ! bean _h be5 remov$ by me*anical means1 &1 z ?is *aff-l sub/ance 0 f\nd to conta9 less tannic acid ?an ! orig9al c(fee1 &1 z ! /atem5t z to ! tannic acid be+ poison\s 0 equally unw>rant$1 x 0 "o ( ! mo/ repreh5sible ( ! class ( :at w\ld n[ be t]m$ misbr&$ sub/ances4 ,z a matt] ( fact ! tannic acid 9 c(fee is 9 su* intimate comb9ation ) ! caffe9e & o!r valuable con/itu5ts ( ! bean t x w\ld be absolutely impossible to remove x )\t de/roy+ ! prop]ties ( ! c(fee s t x w\ld be unrecognizable4 ,! ultimate fate ( ?is article1 :i* p]i%$ along ) sev]al associat$ v5tures1 did n prove a det]r5t to ano!r & /ill m gl>+ fraud ( a simil> "* :i* has be5 adv]tis$ dur+ ! pa/ ye>1 i4 e4 a br& ( c(fee call$ 8,dige/o ,c(fee0 :i* claims to be z h>mless z ! well-kn[n c]eal sub/itutes = ?is agreeable bev]age by virtue ( ! fact t ! poison\s 787 caffe9e & poison\s 787 tannic acid h bo? be5 remov$4 ,i ne$ sc>cely say t su* claims are )\t ! slighte/ f\ndation 9 fact1 & an analysis rec5tly made by me ( ! cont5ts ( a package ( ! article %[$ a slightly high] p]c5tage ( caffe9e ?an ! av]age 9 c(fee1 & no p]ceptible dim9ution 9 ! am\nt ( tannic acid4 ,i ref] to bo? ( ^! in/ances specifically1 z "u all previ\s laws x 0 impossible to proce$ aga9/ ei!r ( ^! firms1 :ile "u ! new law !y are bo? am5able to ! section on misbr&+4 ,z reg>ds ! subject ( drugs1 ! "w ( ,samuel ,hopk9s ,adams 9 ,colli]'s ,magaz9e1 toge!r ) ! assi/ance ( ,mr4 ,bok 9 ! ,ladies' ,home ,j\rnal1 is too well-kn[n to require repetition1 & yet ,i fe> t ! =ce ( ^! argum5ts is lo/ ^u _m p]sons :o look ^u !m z ! fulm9ations ( yell[ j\rnalism4 ,no?+ c\ld be fur!r f ! tru?4 ,! half has nev] be5 told & ! real tru? w probably nev] be kn[n by ! public conc]n+ ! num]\s *anges :i* h be5 made 9 _m well-kn[n prep>ations :i* mu/ n[ decl>e ! pres5ce ( c]ta9 con/itu5ts :i* are enum]at$ 9 ! body ( ! law4 ,among ! bett] kn[n ( ^! sub/ances may be m5tion$ alcohol1 morph9e1 opium1 coca9e1 *lor(orm1 *loral hydrate1 cannabis indica & acetanilide4 ,_m proprietors ( no/rums :i* h be5 entirely dep5d5t ^u _! alcoholic /r5g? = _! m$ic9al & rem$ial effect1 h *ang$ ! =mulas s z to be less liable to criticism1 /ill reta9+ en\gh ( ! orig9al features1 h[ev]1 to make !m objectionable to ^? :o see ?r\gh ! subt]fuge4 ,! numb] ( p]sons 9 ! community :o are really able to judge su* prep>ations is w(ully small & x w require a con/ant campaign ( education = _m ye>s to br+ ! e-day consum] ( prep>ations ( ?is class to a s5se ( 8 p]sonal responsibility 9 su* matt]s4 ,ev5 ! m$ical pr(ession has suff]$ by ?is gigantic bunco game4 ,antikamnia1 a propriet>y prep>ation :i* 0 adv]tis$ = ye>s "u ! claim t x 0 a def9ite syn!tic comp\nd1 9 spite ( ! fact t e "o :o knew any?+ ab\t organic *emi/ry knew bett]1 has at la/ be5 publicly unmask$ z a mixture ( acetanilide1 caffe9e & sodium bic>bonate2 & 9 refuge f ! necessity ( decl>+ ! am\nt ( acetanilide ^u ! label1 ! firm :i* makes x has *ang$ ! =mula s z to sub/itute ph5acet9e = acetanilide1 & yet ! same unw>rant$ & extravagant claims are made = ! prep>ation t 7 made be=e1 ) no notice to ! m$ical pr(ession t a radical *ange has be5 made 9 its composition1 & entirely ignor+ ! /ultification ( ! =m] claims z a def9ite uni=m *emical comp\nd4 ,o!r in/ances might be cit$1 b en\gh has be5 said1 ,i ?9k1 to %[ y t ! effect ( ! law is be+ felt by ^? :o h made !mselves am5able to x4 ,"o important feature mu/ be rememb]$4 ,x is ?is3 ,on e package ( food/uff or drug put up "u ! new law1 ! words 8,gu>ante$ "u ! ,u4 ,s4 ,food & ,drugs ,act1 ,june #cj1 #aijf1 ,s]ial ,no4 ----0 appe>s4 ,?is is be+ us$ 9 su* a way z to make x appe> t ! ,gov]nm5t 9 "s unkn[n way /&s sponsor = ! quality ( ! sub/ance1 :5 9 tru? x is b a compliance ) t "p ( ! ,act1 ,sec4 #i1 :i* says3-- 8,no deal] %all be prosecut$ "u ! provisions ( ?is act :5 he c e/abli% a gu>antee sign$ by ! :olesal]1 jobb]1 manufactur]1 or o!r p>ty resid+ 9 ! ,unit$ ,/ates1 f :om he pur*ases su* article1 to ! effect t ! same is n adult]at$ or misbr&$ )9 ! mean+ ( ?is act designat+ x40 ,?us x w be se5 t ! gu>anty means no?+ m ?an ! ^w ( ! manufactur] t he w be responsible 9 case ( prosecution1 & ,i fe> t n a few ( ! gu>antees at pres5t publi%$ are giv5 )\t due reg>d to facts1 9 ! hope t ! ,dep>tm5t ( ,agriculture1 ) ! trem5d\s task confront+ x ( putt+ ! rules & regulations into practice1 may be a long :ile rea*+ "s ( ^! articles4 ,mean:ile _m p]sons w be delud$ into pur*as+ su* articles 9 ! belief t ! phrase ref]r$ to is evid5ce t ! ,gov]nm5t is responsible = ! claims made1 :5 9 po9t ( fact no?+ ( ! k9d is meant4 ,an in/ance rec5tly com+ to my att5tion1 presumably ( ?is k9d1 is t ( an article :i* is be+ adv]tis$ 9 ! prom95t daily newspap]s 9 ! =m ( read+ notices 7a mo/ repreh5sible =m ( adv]tis+7 z a rem$y = consumption & bron*ial affections4 ,an exam9ation ( ! sub/ance %[s x to be a fictiti\s product conta9+ oil ( turp5t9e1 gum turp5t9e1 ) evid5t traces ( copaiba & s&alwood4 ,x be>s a label :i* indicates a some:at mix$ orig91 z two widely diff]+ plants ( ! p9e family are includ$ 9 ! botanical "n :i* is giv5 = x4 ,9 ! regulation ( ! n>cotic drugs1 su* z opium & its d]ivatives1 morph9e1 coca9e1 etc41 a wond]ful /ep has be5 tak54 ,if ! public c\ld realize ! h>m t has be5 done to p]sons :o h unconsci\sly =m$ drug habits by tak+ propriet>y cat>rh cures !re w\ld be univ]sal amazem5t at ! dep?s ( degradation to :i* a manufactur] w l[] himself 9 ord] to increase ! pr(it on an article by /imulat+ an increase 9 its sale4 ,in/ances h come be=e ! au?orities at ,wa%+ton 9 :i* manufactur]s h frankly admitt$ t !y _h add$ morph9e or coca9e to _! no/rums 9 ord] t _! cont9u$ use might be assur$4 ,!re is mu* "w /ill to be done 9 ! ne> future 9 connection ) ! en=cem5t ( ! act to r5d] its provisions effective1 b ,i believe t ,i h giv5 en\gh examples f ! hundr$s :i* ,i h at my disposal to indicate t ! ultimate effect ( ! ,food & ,drugs ,act1 if x be wisely en=c$1 z is expect$1 w be v mat]ial 9 b5efit+ ! heal? ( ! community at l>ge4 ,,propriet>y ,,prep>ations ,,approv$ ,,by ,,c\ncil ,,on ,,ph>macy ,,& ,,*emi/ry4 ,,ari/o*94 ,ari/o*94--,,co 7,c#bj;,h#be,n#b,o#b7b;,c#da;,h#df,n#d,o #e1 ! neutral c>bonic e/] ( qu99e4 ,actions & ,uses4--,! same z ^? ( qu99e1 b1 s9ce x is only sl[ly act$ on by acids1 x is said n to produce di/urbance ( ! /oma* & to be notably free f t5d5cy to production ( c9*onism4 ,dosage4--,! same z t ( qu99e1 9 p[d]1 mix$ ) milk sug>1 dry on ! tongue or susp5d$ 9 liquids4 ,manufactur$ by ,f>b5fabrik51 vorm4 ,fri$r4 ,bay] ,co41 ,elb]feld1 ,g]many 7,cont95tal ,color ,*emical ,co41 ,new ,york74 ,,ari/ol4 ,a "n appli$ to ,?ymolis iodidum1 ,u4 ,s4 ,p4 ,manufactur$ by ,f>b5fabrik51 vorm4 ,fri$r4 ,bay] ,co41 ,elb]feld1 ,g]many 7,cont95tal ,color ,*emical ,co41 ,new ,york74 ,,aspir94 ,aspir9 ,c#f;,h#d,o7,,*#c;,,co7,,cooh #a3b ,c#i;,h#h,o#d1 ! acetyl d]ivative ( salicylic acid4 ,actions & ,uses4--,x acts l salicylic acid1 ov] :i* x possesses ! advantage ( produc+ less ( ! undesir$ local & sy/emic side effects1 on acc\nt ( ! sl[ lib]ation ( ! salicylic acid4 ,x passes ! /oma* un*ang$1 ! decomposition beg9n+ 9 ! inte/9e4 ,dosage4--#jc to #a gramme 7#e to #ae gra9s7 9 capsules or waf]s1 or dissolv$ 9 sweet5$ wat] or dry on ! tongue1 foll[$ by a swall[ ( wat]4 ,! p[d] %\ld be disp5s$ 9 wax$ pap]4 ,manufactur$ by ,f>b5fabrik51 vorm4 ,fri$r4 ,bay] ,co41 ,elb]feld1 ,g]many 7,cont95tal ,color ,*emical ,co41 ,new ,york74 ,,b5zosol4 ,b5zosol1 ,c#f;,h#d7,,o*#c7 7,c#f;,h#e;,,coo7 ,c#ad;,h#ab,o#c1 a cry/all9e comp\nd ( guaiacol 9 :i* ! hydrog5 ( ! hydroxyl is replac$ by b5zoyl4 ,actions & ,uses4--,b5zosol is decompos$ sl[ly 9 ! inte/9al tract into guaiacol & b5zoic acid :i* ex]t _! prop] actions4 ,! lib]at$ con/itu5ts are absorb$ & excret$ 9 ! ur9e4 ,x is n irritat+4 ,its uses are analog\s to ^? ( creosote & ( b5zoic acid4 ,x is recomm5d$ 9 incipi5t pulmon>y tub]culosis1 z an inte/9al antiseptic 9 f]m5tation1 di>rhea1 typhoid fev]1 diabetes mellitus & z a ur9>y dis9fectant 9 cy/itis1 etc4 ,dosage4--#jb to #jf gramme 7#c to #aj gra9s71 9 p[d]1 capsule1 pill1 or susp5d$ 9 liquids or z an emulsion4 ,manufactur$ by ,f>bw]ke1 vorm4 ,mei/]1 ,lucius ,bru5+1 ,hoe*/ a4 ,m4 7,victor ,koe*l ,co41 ,new ,york74 ,,beta-,,euca9e ,,hydro*loride4 ,beta-euca9e hydro*loride1 ,c#e;,h#g,n7,,*#c7c7;,c#f;,h#e;,,coo7,h, cl1 ! hydro*loride ( #b1f1f trime?yl-#d-;b5zoyl-hydroxypip]id9e4 ,actions & ,uses4--,beta-euca9e hydro*loride is a local ane/hetic l coca9e1 b weak] & devoid ( ! /imulat+ prop]ties ( ! latt]4 ,x does n dilate ! pupil1 nor does x contract ! blood-vessels z does coca9e4 ,x has ! advantage ( /ability ev5 on prolong$ boil+4 ,x may be us$ 9 all cases 9 :i* coca9e is indicat$ z a local ane/hetic1 especially 9 oph?almology4 ,dosage4--,x may be appli$ 9 a #b to #c p] c5t4 solution to ! eye1 #e to #aj p] c5t4 = nose & ?roat1 & #e to #aj p] c5t4 = o9tm5t = hemorrhoids4 ,manufactur$ by ,*emis*e ,fabrik auf ,acti51 vorm4 ,e4 ,s*]+1 ,b]l9 7,s*]+ ,glatz1 ,new ,york74 ,,beta-,,naph?ol ,,b5zoate4 ,beta-naph?ol b5zoate1 ,c#f;,h#e;,,coo,c#aj;,h#g ,c#ag;,h#ab,o#b1 ! b5zoic e/] ( -naph?ol4 ,actions & ,uses4--,beta-naph?ol b5zoate is split up into its con/itu5ts on rea*+ ! inte/9al tract & acts z an antiseptic4 ,x is said to be diuretic4 ,x is us$ int]nally z an inte/9al antiseptic 9 di>rhea & typhoid fev]4 ,ext]nally x has be5 recomm5d$ z a p>asiticide 9 ! =m ( #c to #aj p] c5t4 o9tm5t1 & has be5 us$ 9 psoriasis1 eczema1 scabies1 etc4 ,dosage4--#jb to #je gramme 7#c to #h gra9s72 maximum dose1 s+le1 #a gramme 7#ae gra9s71 daily #d grammes 7#fj gra9s74 ,manufactur$ by ,fabrik von ,heyd51 ,radebeul ne> ,dresd5 7,m]ck ,co41 ,new ,york74 ,,betol4 ,betol1 ,c#f;,h#d,,oh,,coo 7,c#aj;,h#g7 ,c#ag;,h#ab,o#c1 ! salicylic e/] ( -naphtol4 ,actions & ,uses4--,betol is n affect$ 9 ! /oma*1 b is split up 9 its orig9al compon5ts :5 x rea*es ! inte/9al tract by ! pancreatic juice & inte/9al secretions4 ,x is believ$ to act z an inte/9al antiseptic &1 be+ excret$ 9 ! ur9e1 to act 9 a simil> way 9 ! bladd]4 ,x has ! anti-rheumatic prop]ties ( salicylic acid4 ,x is recomm5d$ = inte/9al f]m5tations1 cat>rh ( ! bladd]1 p>ticul>ly 9 gonorrheal cy/itis1 = rheumatism1 etc4 ,dosage4--#jc to #je gramme 7#d to #h gra9s7 9 ca*ets1 milk or emulsion4 ,manufactur$ by ! ,heyd5 ,*emical ,works1 ,new ,york4 ,,bismal4 ,bismal1 #d 7,c#ae;,h#ab,o#aj7c;,bi7,,oh7#c ,bi#c;,c#fj;,h#eg,o#di1 a comp\nd ( bismu? hydroxide & me?yl5digallic acid4 ,actions & ,uses4--,bismal is an a/r+5t & is recomm5d$ = ! treatm5t ( *ronic di>rhea4 ,dosage4--#jab to #jc gramme 7#b to #e gra9s7 9 ca*ets or p[d]4 ,manufactur$ by ,e4 ,m]ck1 ,d>m/adt4 7,m]ck ,co41 ,new ,york47 ,,boro*loretone4 ,a mixture ( #a "p *loretone ) #c p>ts boric acid4 ,actions & ,uses4--,an antiseptic & ane/hetic1 us$ ext]nally z a surgical dress+ p[d]4 ,prep>$ by ,p>ke1 ,davis ,co41 ,detroit1 ,mi*4 ,,brometone4 ,brometone1 #a1a1a-tribrom-#b-me?yl-propan-#b-ol1 ,c,br#c;,c7,,oh7 7,,*#c7;,,*#c ,c#d;,h#g,o,br#c1 produc$ by ! reaction ( acetone on brom(orm4 ,actions & ,uses4--,brometone is claim$ to h ! s$ative action ( ! bromides )\t ! disadvantage ( produc+ bromism4 ,9 doses ( #jc gramme 7#e gra9s7 f\r or five times a day1 9 adults1 x is claim$ to cause no unpleasant results & to produce no di/urbance ( ! dige/ive organs1 & to h no appreciable effect on ! secretions4 ,its action is prompt & its effect is manife/ = sev]al h\rs4 ,9 doses exce$+ #af grammes 7#be gra9s7 daily x may produce dizz9ess1 v]tigo1 anorexia1 & m5tal hebetude1 all ( :i* symptoms disappe> on discont9uance ( its use4 ,!rapeutically x has be5 recomm5d$ 9 mild conditions ( excitation & insomnia1 9 s-call$ n>cotic ab/95ce1 9 hy/]ia1 & 9 n]v\s affections g5]ally4 ,x relieves "s =ms ( c\gh & is said to produce amelioration 9 ab\t #fj p] c5t4 ( cases ( epilepsy4 ,x has be5 us$ to relieve dizz9ess due to labyr9?9e di/urbances4 ,dosage4--,! dose is #jc gramme 7#e gra9s71 to be repeat$ two or ?ree times dur+ tw5ty-f\r h\rs4 ,manufactur$ by ,p>ke1 ,davis ,co41 ,detroit1 ,mi*4 ,,bromip94 ,a brom9e addition product ( sesame oil1 conta9+ #aj p] c5t4 ( brom9e 9 organic comb9ation4 ,actions & ,uses4--,bromip9 acts l ! bromides1 b z x yields its brom9e m sl[ly x is ?\ght to h less t5d5cy to produce brom9ism4 ,! comb9ation is n brok5 up 9 ! /oma*1 b a portion ( ! brom9e is split (f z soon z ! oil ent]s ! inte/9e4 ,! oil ) ! rema9+ brom9e is easily absorb$1 &1 simil>ly to o!r fats1 is l>gely deposit$ 9 ! tissues1 :]e x is sl[ly split up4 ,x is said to be m la/+ 9 its action ?an ! bromides4 ,dosage4--#d c4c4 7#a fluidra*m71 increas$ 9 cases ( epilepsy to f #h to #cb c4c4 7#b to #h fluidra*ms72 9 emulsion ) pepp]m9t wat] & syrup1 or pure1 flavor$ ) oil ( pepp]m9t4 ,manufactur$ by ,e4 ,m]ck1 ,d>m/adt4 7,m]ck ,co41 ,new ,york47 ,,bromip9--#cc ,,p] ,,c5t4 ,a #cc p] c5t4 brom9iz$ sesame oil4 ,manufactur$ by ,e4 ,m]ck1 ,d>m/adt4 7,m]ck ,co41 ,new ,york47 ,,butyl-,,*loral ,,hydrate4 ,actions & ,uses4--,its action is simil> to t ( *loral1 except t x is said to be less depress+ & m analgetic4 ,x has be5 especially recomm5d$ = facial neuralgia4 ,dosage4--#jc to #ac grammes 7#e to #bj gra9s74 ,,calcium ,,i*?yol4 ,a d]ivative ( i*?yol 9 :i* calcium is sub/itut$ = ammonium4 ,manufactur$ by ! ,i*?yol ,company1 ,hamburg4 7,m]ck ,co41 ,new ,york47 ,,calomelol4 ,a soluble colloidal =m ( calomel1 conta9+ album9oids4 ,actions & ,uses4--,its action is ! same z t ( calomel1 b x is claim$ to be sup]ior because ( its solubility 9 wat]1 act+ m rapidly & effici5tly4 ,calomelol is claim$ to be non-irritant & p>ticul>ly non-toxic4 ,! indications = its use are ! same z = calomel4 ,dosage4--,int]nally ! same z calomel4 ,ext]nally x is us$ z a du/+ p[d]1 mix$ ) an equal quantity ( />* or ( a mixture ( />* & z9c oxide1 or 9 ! =m ( calomelol o9tm5t4 ,x %\ld be gu>d$ f ! light4 ,manufactur$ by ! ,heyd5 ,*emical ,works1 ,new ,york4 ,,calomelol ,,o9tm5t4 ,actions & ,uses4--,x is a sub/itute = m]curial o9tm5t1 ov] :i* x has ! advantage ( cleanl9ess1 & x is claim$ to be di/9ctly sup]ior z an inunction 9 syphilis1 etc4 ,dosage4--#f grammes 7#ij gra9s7 daily = inunction 9 syphilis4 ,manufactur$ by ! ,heyd5 ,*emical ,works1 ,new ,york4 ,,casc>a ,,evacuant4 ,a prep>ation said to conta9 a bitt]less glucoside1 obta9$ f ! b>k ( ,rhamnus ,pur%iana1 ) aromatics4 ,actions & ,uses4--,x is claim$ t ?is prep>ation possesses ! laxative prop]ties ( casc>a sagrada )\t ! bitt]ness :i* *>act]izes ! ord9>y extract4 ,x is recomm5d$ = ! treatm5t ( *ronic con/ipation1 = :i* casc>a sagrada is "o ( ! be/ m$ic9al ag5ts4 ,dosage4--,z a laxative1 #jf to #a c4c4 7#aj to #ae m9ims7 ?ree times a day2 z a purgative1 #ac to #b c4c4 7#bj to #cj m9ims7 morn+ & ev5+4 ,f\r cubic c5timet]s 7#a fluidra*m7 may be giv5 9 ob/9ate cases4 ,prep>$ by ,p>ke1 ,davis ,co41 ,detroit1 ,mi*4 ,,casc>a ,,tonic ,,laxative ,,globules4 ,ea* globule is said to conta9 #jb gramme 7#c gra9s7 ( ! bitt] glucosides ( ,rhamnus ,pur%iana susp5d$ 9 a bl& fix$ oil1 to :i* aromatics h be5 add$4 ,actions & ,uses4--,! manufactur]s claim t x comb9es ! laxative action ( casc>a ) tonic prop]ties ( ! bitt] pr9ciple ) ! advantage ( concealm5t ( ! disagreeable ta/e4 ,dosage4--,"o or two globules to be tak5 be=e retir+4 ,prep>$ by ,p>ke1 ,davis ,co41 ,detroit1 ,mi*4 ,,*9aph594 ,*9aph591 ,,co 7,,nh,c#f;,h#d,,oc#b;,h#e7 7,c#bj;,h#bc,n#b,o#b7 ,c#bj;,h#cc,n#c,o#d1 ! qu99e c>bonic acid e/] ( ph5etid94 ,actions & ,uses4--,*9aph59 comb9es ! antip]iodic prop]ties ( qu99e ) ! analgesic p[] ( ph5acet91 ) ! advantage ( ta/elessness & ass]t$ fre$om f symptoms ( c9*onism produc$ by ! adm9i/ration ( ! two rem$ies 9 simple mixture4 ,x is recomm5d$ 9 febrile diseases1 especially la grippe2 9 spasmodic conditions1 su* z :oop+-c\gh2 9 c]ta9 =ms ( mal>ia & 9 neuralgia4 ,dosage4--,adult3 #jc to #jf gramme 7#e to #aj gra9s7 ord9>ily1 #ae to #b grammes 7#bb to #cj gra9s71 giv5 9 two doses z an antipyretic 9 neuralgia & mal>ia2 9 :oop+-c\gh3 #jac to #jc gramme 7#b to #e gra9s71 accord+ to age4 ,manufactur$ by ,f>b5fabrik51 vorm4 ,fri$r4 ,bay] ,co41 ,elb]feld1 ,g]many 7,cont95tal ,color ,*emical ,co41 ,new ,york74 ,,*lorbutanol4 ,*lorbutanol1 #a1a1a-tri*lor-#b-me?yl-propan-#b-ol1 ,c,cl#c;,c 7,,oh7 7,,*#c7;,,*#c ,c#d;,h#g,o,cl#c1 produc$ by ! reaction ( acetone on *lor(orm4 ,actions & ,uses4--,x is said to be absorb$ un*ang$1 b to be decompos$ 9 ! body4 ,x is a local ane/hetic ) an action weak] ?an t ( coca9e1 b suffici5t to prev5t vomit+ f ga/ric irritation4 ,its antiseptic action is said to be fifte5 times z /rong z t ( boric acid4 ,x acts on ! c5tral n]v\s sy/em simil>ly to *loral1 & al?\gh ! claim has be5 made t hypnotic doses are )\t effect on ! circulation & respiration1 indep5d5t obs]v]s h describ$ a fall ( blood pressure & int]f]5ce ) respiration 9 animals1 & consid] x fully z dang]\s z *loral4 ,9 man #ajj gra9s caus$ sev]e symptoms1 b recov]y occurr$4 ,x is claim$ t no habit is induc$1 b ?is may be ref]able to its re/rict$ employm5t4 ,x is recomm5d$ z a mild local ane/hetic1 9 d5ti/ry1 etc41 z a pres]vative = hypod]mic solutions1 = insomnia1 vomit+ & = spasmodic conditions4 ,x is also said to be useful z introductory to g5]al ane/hesia1 less5+ excitem5t & nausea4 ,dosage4--,! dose is f #jc to #ae gramme 7#e to #bj gra9s7 dry or 9 capsules4 ,hypod]mically z a local ane/hetic a saturat$ aque\s solution may be us$4 ,,*loretone4 ,a "n appli$ to *lorbutanol1 :i* see4 ,manufactur$ by ,p>ke1 ,davis ,co41 ,detroit1 ,mi*4 ,,*loretone ,,inhalant4 ,a solution ( *loretone1 camphor1 m5?ol & oil ( c9namon 9 liquid petrolatum4 ,actions & ,uses4--,an anodyne1 antiseptic1 & emoli5t solution = use by inhalation z a v f9e spray or nebula4 ,manufactur$ by ,p>ke1 ,davis ,co41 ,detroit1 ,mi*4 ,,cit>94 ,cit>91 ,,*#b;,c,o,o,na ,,*#b _/ _/ ,,co ,o ,na#b;,c#g;,h#f,o#g1 ! normal sodium salt ( _/ _/ ,,co ,,*#b;,c,o,o,na anhydrome?yl5e-citric acid4 ,actions & ,uses4--,?is is "o ( ! comp\nds :i* x is claim$ increase ! elim9ation ( uric acid by =m+ v soluble comp\nds ) t sub/ance4 ,x has be5 recomm5d$ = g\t & *ronic rheumatism4 ,dosage4--#a to #b grammes 7#ae to #cj gra9s71 l>gely dilut$ ) wat]4 ,manufactur$ by ,f>b5fabrik51 vorm4 ,fri$r4 ,bay] ,co41 ,elb]feld1 ,g]many 7,cont95tal ,color ,*emical ,co41 ,new ,york74 ,,creosotal4 ,a mixture ( c>bonic acid e/]s1 analog\s to guaiacol c>bonate1 prep>$ f creosote4 ,actions & ,uses4--,creosotal has ! same action z creosote1 b is claim$ to be non-toxic & devoid ( irritant prop]ties4 ,x is recomm5d$ z a sub/itute = creosote = int]nal exhibition 9 tub]culosis1 pneumonia1 & z an inte/9al antiseptic4 ,dosage4--,f #jc to #bj grammes 7#e to #cj gra9s7 = *ildr51 to #a to #d grammes 7#ae to #fj gra9s7 = adults 9 milk1 c(fee1 w9e1 cod-liv] oil or emulsion4 ,ext]nally x may be appli$ undilut$4 ,manufactur$ by ,f>b5fabrik51 vorm4 ,fri$r4 ,bay] ,co41 ,elb]feld1 ,g]many 7,cont95tal ,color ,*emical ,co41 ,new ,york74 ,fabrik von ,heyd51 ,radebeul1 ne> ,dresd54 ,,d5talone4 ,a #cj p] c5t4 solution ( *loretone 9 a mixture ( oils ( gaul!ria1 cloves & cassia4 ,actions & ,uses4--,d5talone possesses pron\nc$ ane/hetic prop]ties & is int5d$ = use by d5ti/s 9 ! treatm5t ( expos$ n]ves 9 decay$ tee?4 ,prep>$ by ,p>ke1 ,davis ,co41 ,detroit1 ,mi*4 ,,d]matol4 ,a "n appli$ to ,bismu?i ,subgallas1 ,u4 ,s4 ,p4 ,manufactur$ by ,mei/]1 ,lucius ,bru5+1 ,hoe*/ a4 ,m4 7,victor ,koe*l ,co41 ,new ,york74 ,,diabet94 ,a pure1 cry/alliz$ fructose 7levulose71 ,,*#b,,oh,,*oh,,*oh4 ,,*oh,,co,,*#b,,oh ,c#f;,h#ab,o#f1 absolutely free f dextrose 7ord9>y glucose74 ,actions & ,uses4--,levulose is metaboliz$ 9 ! body by o!r ag5cies ?an ^? t act on dextrose & mo/ ( ! o!r sug>s & appe>s to be m completely utiliz$ by ! diabetic organism ?an ! o!r sug>s4 ,x is recomm5d$ = ! nutrition & = sweet5+ ! food & dr9k ( diabetics1 9 pulmon>y tub]culosis1 infantile malnutrition & m>asmus4 ,dosage3--,x is giv5 9 diabetes 9 daily quantities ( #cj to #fj grammes 7#a to #b ounces72 9 grave =ms ( ! disease ! am\nt is r$uc$ to f #ab to #bd grammes 7#c to #f dra*ms7 daily4 ,manufactur$ by ,*emis*e ,fabrik auf ,acti51 vorm4 ,e4 ,s*]+1 ,b]l9 7,s*]+ ,glatz1 ,new ,york74 ,,dion94 ,dion91 ,c#ag;,h#ag,,no7,,oh7 7,,oc#b;,h#e;,h,cl7 ,h#b,o 7,c#ai;,h#ba,o#c;,cl,n ,h#b,o71 ! hydro*loride ( ! e?yl e/] ( morph9e4 ,actions & ,uses4--,x is claim$ t ?is comp\nd acts l morph9e )\t produc+ con/ipation1 nausea or lassitude4 ,x is ! conclusion ( "s good obs]v]s t x possesses no advantage ov] code9e4 ,appli$ to ! eye1 x causes a local vasodilation1 lead+ to acute conjunctival edema4 ,dion9 is recomm5d$ to relieve pa91 especially 9 respiratory affections1 z an antispasmodic 9 :oop+-c\gh1 = insomnia & ext]nally 9 ! treatm5t ( corneal affections1 conjunctivitis1 iritis1 etc4 ,dosage4--#jjae to #jjf gramme 7 to #a gra974 ,ext]nally x is appli$ 9 #aj to #bj p] c5t4 solutions4 ,manufactur$ by ,e4 ,m]ck1 ,d>m/adt4 7,m]ck ,co41 ,new ,york47 ,,diuret94 ,a "n appli$ to !obrom9e-sodium salicylate1 :i* see4 ,manufactur$ by ,knoll ,co41 ,ludwig%af51 ,g]many 7,e4 ,m]ck ,co41 ,new ,york74 ,,duotal4 ,a "n appli$ to ,guaiacolis ,c>bonas1 ,u4 ,s4 ,p4 ,manufactur$ by ,f>b5fabrik51 vorm4 ,fri$r4 ,bay] ,co41 ,elb]feld1 ,g]many 7,cont95tal ,color ,*emical ,company1 ,new ,york74 ,,duotonol4 ,a "n appli$ to a mixture ( equal p>ts ( calcium tonol & sodium tonol4 7,see ,tonols47 ,actions & ,uses & ,dosage4--,see ,glyc]ophosphates4 ,manufactur$ by ,*emis*e ,fabrik auf ,acti51 vorm4 ,e4 ,s*]+1 ,b]l9 7,s*]+ ,glatz1 ,new ,york74 ,,elixir ,,eupne94 ,a prep>ation said to conta9 9 ea* dose ( #h c4c4 7#b fluidra*ms73 h]o9 #jjjbf gramme 7#a_/bd gra971 t]p9 hydrate #jac gramme 7#b gra9s7 creosote #jc gramme 7#e gra9s71 9 a m5/ruum conta9+ #cj p] c5t4 ( alcohol ) glyc]9 & aromatic ess5tial oils4 ,actions & ,uses4--,f its composition x appe>s to be well adapt$ to use 9 *ronic c\gh f bron*itis1 etc4 ,dosage4--#d to #ab c4c4 7#a to #c fluidra*ms74 ,prep>$ by ,s*ieffel9 ,co41 ,new ,york4 ,,elixir ,,saw ,,palmetto4 ,an elixir ( saw palmetto b]ries1 s&al wood & cornsilk4 ,actions & ,uses4--,! con/itu5ts ( ?is prep>ation are cr$it$ ) diuretic prop]ties & believ$ to be s$ative to ! g5ito-ur9>y tract & to ex]t a curative action on ! inflam$ muc\s membrane1 especially 9 *ronic cases4 ,dosage4--#d to #af c4c4 7#a to #d fluidra*ms7 ?ree times a day4 ,prep>$ by ,p>ke1 ,davis ,co41 ,detroit1 ,mi*4 ,,empyr(orm4 ,a cond5sation product ( bir* t> & =maldehyde4 ,actions & ,uses4--,empyr(orm is an antipruritic1 s$ative & desiccant4 ,x is said to be sup]ior to t> & free f irritant or toxic effects4 ,x is claim$ to be useful 9 all /ages ( eczema1 psoriasis1 li*51 urtic>ia1 prurigo1 pityriasis1 etc4 ,dosage4--,x is appli$ z a #e to #aj p] c5t4 o9tm5t1 #aj to #bj p] c5t4 z9c pa/e1 #aj to #bj p] c5t4 t9cture1 & #cge p] c5t4 susp5sion4 ,manufactur$ by ,*emis*e ,fabrik auf ,acti51 vorm4 ,e4 ,s*]+ ,b]l9 7,s*]+ ,glatz1 ,new ,york74 ,,epic>94 ,epic>91 ,c#f;,h#c7,,oh77,,cooh7 7,,*#b;,c#aj;,h#f,,oh7 #b3c3a ,c#ah;,h#ad,o#d1 -naph?ol-hydroxy-toluic acid4 ,actions & ,uses4--,epic>9 is a non-poison\s antiseptic & p>asiticide4 ,adm9i/]$ int]nally1 x is excret$ mo/ly undecompos$4 ,x has be5 f\nd useful 9 ! treatm5t ( sk9-diseases1 p>ticul>ly scabies1 t9ea tonsurans1 prurigo & c]ta9 =ms ( eczema4 ,dosage4--,x is us$ ext]nally only 9 ! =m ( #e to #bj p] c5t4 o9tm5t1 ) petrolatum or wool fat 7lanol97 z base1 or 9 ! =m ( oily or alcoholic solutions 7#aj p] c5t474 ,manufactur$ by ,f>b5fabrik51 vorm4 ,fri$r4 ,bay] ,co41 ,elb]feld1 ,g]many 7,cont95tal ,color & ,*emical ,co41 ,new ,york74 ,,ery?rol ,,tetranitrate4 ,ery?rol tetranitrate1 ,c#d;,h#f7,,no#c7d ,c#d;,h#f,o#ab,n#d1 ! tetranitrate ( ery?rite or butane-tetrol1 ,c#d;,h#f7,,oh7#d4 ,actions & ,uses4--,x is a vasodilator & antispasmodic1 l nitroglyc]94 ,its action is sl[] & m la/+2 x beg9s 9 #ae m9utes & p]si/s = ?ree or f\r h\rs4 ,x is recomm5d$ 9 ang9a pectoris & c>diac diseases4 ,x is report$ z especially useful z a prophylactic 9 prev5t+ ang9al pa94 ,dosage4--,because ( its explosiv5ess x is m>ket$ 9 ! =m ( tablets1 ea* conta9+ #j4jc gramme 7 gra974 ,"o or two tablets e f\r to six h\rs4 ,manufactur$ by ,e4 ,m]ck1 ,d>m/adt 7,m]ck ,co41 ,new ,york74 ,,e?yl5$iam9e4 ,e?yl5$iam9e1 ,c#b;,h#d7,,nh#b7b1 a sub/itution comp\nd ( e?yl5e & ammonia4 ,actions & ,uses4--,x is said to be non-corrosive4 ,x is recomm5d$ z an album9 solv5t = ! solution ( false membranes 9 diph!ria & simil> affections ( ! muc\s membranes4 ,x is recomm5d$ = use 9 ! =m ( kresam9e 7:i* see74 ,manufactur$ by ,*emis*e ,fabrik auf ,acti51 vorm4 ,e4 ,s*]+1 ,b]l9 7,s*]+ ,glatz1 ,new ,york74 ,,euca9e4 ,! 8,euca9es0 are two closely alli$ syn!tic bases1 :i* 7 orig9ally diff]5tiat$ z euca9e 8,a0 & euca9e 8,b10 b are n[ designat$ z 8,alpha-euca9e0 & 8,beta-euca9e10 respectively1 alpha-euca9e be+ a syn!tic d]ivative ( triacetonam9e1 :ile beta-euca9e is a syn!tic d]ivative ( v9yl-diacetonekalm9e4 ,bo? ( ^! bases are suppli$ z hydro*lorides & are recomm5d$ z sub/itutes = coca9e1 ov] :i* !y are claim$ to h c]ta9 advantages4 ,!y are describ$ "u alpha-euca9e hydro*loride & beta-euca9e hydro*loride4 7,to be cont9u$47 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry1 f ! ,j\rnal ,a4 ,m4 ,a41 ,octob] #bj1 #aijf4 ,,tyree',s ,,antiseptic ,,p[d]4 ,tyree's antiseptic p[d] 0 assign$ = exam9ation to a subcommittee ( ! ,c\ncil1 :i* made ! foll[+ report3 ,to ! ,c\ncil on ,ph>macy & ,*emi/ry3 ,y\r subcommittee1 to :om 0 assign$ ,tyree's ,pulv4 ,antiseptic ,comp41 m>ket$ by ,j4 ,s4 ,tyree1 ,wa%+ton1 ,d4 ,c41 reports z foll[s3 ,! label on ! package /ates3 8,?is prep>ation is a sci5tific comb9ation ( borate ( sodium1 alum51 c>bolic acid1 glyc]9 & ! cry/alliz$ pr9ciples ( ?yme1 eucalyptus1 gaul!ria1 & m5?a1 9 ! =m ( a p[d]10 etc4 ,! /atem5t t ! p[d] conta9s ! cry/all9e pr9ciples ( ?yme1 eucalyptus1 gaul!ria & m5?a is vague & mislead+1 s9ce ! *ief m$ical con/itu5ts ( eucalyptus & gaul!ria are liquids1 b x t5ds to convey ! impression t ! p[d] conta9s ! ess5tial con/itu5ts ( ^! drugs1 namely1 ?ymol1 oil ( eucalyptus or eucalyptol1 oil ( w9t]gre51 or me?yl salicylate1 & m5?ol4 ,! lit]ature suppli$ to physicians claims its composition to be3 8,p>ts1 sod4 bor41 #ej2 alum51 #ej2 ac4 c>bol41 #e2 glyc]91 #e2 ! cry/4 pr9ciples ( ?yme1 #e2 eucalyptus1 #e2 gaul!ria1 #e1 & m5?a1 #e40 ,! composition1 !re=e1 might be express$ z foll[s3-- ,sodium borate 7borax7 #ej p>ts1 or #chdf p] c5t4 ,alum #ej p>ts1 or #chdf p] c5t4 ,ph5ol 7c>bolic acid7 #e p>ts1 or #che p] c5t4 ,glyc]9 #e p>ts1 or #che p] c5t4 ,?ymol #e p>ts1 or #che p] c5t4 ,oil ( eucalyptus or eucalyptol #e p>ts1 or #che p] c5t4 ,oil ( gaul!ria 7or m5?yl salicylate7 #e p>ts1 or #che p] c5t4 ,m5?ol #e p>ts1 or #che p] c5t4 ,analysis ( specim5s pur*as$ f diff]5t s\rces 9 ! op5 m>ket 7 made "u our direction4 ,! reports ( ! *emi/s %[ t ,tyree's antiseptic p[d] conta9s no borax1 or m]e traces only1 & t x conta9s no alum1 or m]e traces only4 ,in/ead1 ! analyses %[ t boric acid & z9c sulphate are ! ess5tial con/itu5ts4 ,! am\nts ( c>bolic acid1 ?ymol1 m5?ol1 etc41 conta9$ 9 ! p[d]1 if pres5t1 7 f> bel[ ! quantities indicat$ by ! =mula4 ,! pres5ce ( glyc]9 c\ld n be demon/rat$1 & if pres5t ! am\nt mu/ be v small4 ,our *emi/ reports3-- ,! result ( analysis %[s t diff]5t samples diff] slightly 9 composition1 b t ! foll[+ indicates ! av]age composition ( ! product3-- ,p] c5t4 ,z9c sulphate1 anhydr\s #ae4ef4 ,boric acid #ha4bf4 ,volatile matt] at #ajj ,c4 = f\r h\rs #j4de4 ,! undet]m9$ portion consi/s ( salicylic acid1 c>bolic acid1 m5?ol & eucalyptol2 possibly o!r antiseptic ag5ts may be pres5t 9 v m9ute quantities4 ,f ! above f9d+s we conclude t ,tyree's antiseptic p[d] is a mixture ( boric acid & dri$ z9c sulphate & antiseptic bodies1 su* z m5?ol1 salicylic acid & c>bolic acid1 eucalyptol1 etc4 ,f ?is x c be readily se5 t ! label :i* is suppos$ to set =? ! composition ( ,tyree's antiseptic p[d] is n 9 accord ) ! facts4 ,! p[d] does n conta9 ei!r borate ( sodium or alum1 & ! pres5ce ( glyc]9 c\ld n be e/abli%$4 ,! antiseptic ag5ts1 exclusive ( ! boric acid1 are pres5t only 9 small am\nts4 ,! report ( ano!r analy/ concludes z foll[s3 ,x evid5tly conta9s less ?an ! am\nt /at$ ( ! pr9ciples ( ?yme1 eucalyptus1 w9t]gre5 & m9t4 ,x also conta9s a v small am\nt inde$ ( c>bolic acid1 mu* less ?an t /at$4 ,we h be5 unable to id5tify c]ta9ly ! pres5ce ( glyc]91 & x is d\btful if x be pres5t4 ,f ! result ( ! analysis we feel confid5t t ! prep>ation is to all int5ts & purposes a mixture ( boric acid & sulphate ( z9c4 ,! c>bolic acid1 ?yme1 eucalyptus1 w9t]gre51 etc41 if pres5t1 are pres5t only 9 suffici5t am\nt to give ! comp\nd a satisfactory odor4 ,9 view ( ! fact t ,j4 ,s4 ,tyree has giv5 wide publicity to a =mula :i* ! prec$+ report has %[n to be a delib]ate misrepres5tation ( fact1 x is recomm5d$ t ! article be refus$ recognition by ! ,c\ncil on ,ph>macy & ,*emi/ry1 & t ?is report be publi%$ 9 ! ,j\rnal ( ! ,am]ican ,m$ical ,association4 ,! recomm5dation ( ! subcommittee 0 adopt$ by ! ,c\ncil 9 accordance ) :i* ! report is publi%$4 ,w4 ,a4 ,,puckn]1 ,secret>y4 ,9 a lett] to ! editor ( ! ,j\rnal ( ! ,am]ican ,m$ical ,association1 ,mr4 ,tyree admits *ang+ ! =mula ( ! p[d]1 & says t x _h be5 8 int5tion to /ate to ! m$ical pr(ession 8 reasons = mak+ ! *ange4 ,9 comm5t+ on ! lett] x is not$ t ,mr4 ,tyree does n /ate :e!r ! *ange 0 made "o ye> ago or five ye>s ago1 b ! sample = ! fir/ analysis 0 pur*as$ la/ ,febru>y1 & ! fir/ *emi/'s report 0 submitt$ to ! ,c\ncil ,m>* #e1 #aijf4 ,on ,april #d?1 ,mr4 ,tyree 0 notifi$ by ! ,c\ncil t ! composition ( 8,tyree's ,antiseptic ,p[d]0 did n correspond ) ! =mula publi%$ by him4 ,:e!r or n ,mr4 ,tyree is ju/ifi$ 9 (f]+ to physicians a prep>ation z compos$ *iefly ( borax & alum1 :5 9 reality x is compos$ ( boric acid & z9c sulphate1 is left = physicians to judge4 ,,fraud ,,& ,,deception ,,9 ,,prep>ations ,,( ,,cod-,,liv] ,,oil4 ,! ,j\rnal ( ! ,am]ican ,m$ical ,association1 ,octob] #ac1 #aijf1 exposes ! fraud & deception practis$ by c]ta9 propriet>y firms 9 putt+ on ! m>ket prep>ations purport+ to conta9 cod-liv] oil1 :51 9 fact1 !y conta9 no oil at all4 ,x is conc$$ by ph>macologi/s t ! value ( ^! rem$ies dep5ds on ! nutritive p[] ( ! fat1 & any prep>ation :i* conta9s fat mu/ respond to simple te/s :i* ! physician c p]sonally apply4 ,! prep>ations claim+ to repres5t cod-liv] oil are 9 liquid =m1 & if !y conta9 oil x mu/ be 9 "o ( ! foll[+ =ms3 7#a7 ,an emulsion ( ! oil :i* may be miscible ) wat]1 b f :i* ! fat t5ds to sep>ate & rise to ! top4 ,9 ?is =m ! fat c be se5 z globules "u ! microscope4 7#b7 ,a solution1 result+ f ! saponification ( ! oil1 conta9+ a soap :i* usually w be alkal9e 9 reaction1 especially :5 mix$ ) wat]1 & f :i* fatty acids are sep>at$ z a precipitate :5 ! solution is acidifi$4 7#c7 ,a solution ( fatty acids4 ,?is w be acid 9 reaction & w be precipitat$ by ! addition ( wat]1 9 :i* ! fatty acids are n soluble4 ,an exam9ation ( "o ( ^! prep>ations1 e4 g41 ,wat]bury's ,metaboliz$ ,cod-,liv] ,oil1 :i*1 x is claim$1 8conta9s ! metaboliz$ product obta9$ by ! action ( f]m5ts on cod-liv] oil10 %[s t x is nei!r an emulsion1 a solution ( soap1 nor a solution ( fatty acids1 & m c>eful analysis %[s t x conta9s no fat or fat acids 7except ! m]e/ traces74 ,no intellig5t physician %\ld be misl$ by ! extravagant & unf\nd$ claims made = ?is prep>ation4 ,hagee's ,cordial ( ,cod-,liv] ,oil is a repres5tative ( a class ( prep>ations :i* claim to 8repres5t ! oil1 b conta9 no fat10 & are !re=e practically wor?less4 ,! claims ( !rapeutic value = su* prep>ations c n be sub/antiat$4 ,"s su* rem$ies are adv]tis$ z extracts ( cod-liv] oil1 :51 9 fact1 !y are made f cod liv]s1 b n f cod-liv] oil4 ,^! prep>ations1 if hone/ly made1 might be wor?y ( a trial1 b !y are n prep>ations ( cod-liv] oil1 & %\ld n be s t]m$4 ,s f> z we "k1 h[ev]1 no satisfactory evid5ce is =?com+ t su* extractives h any !rapeutic value4 ,! attempt to modify cod-liv] oil = !rapeutic purposes may be pron\nc$ a failure & ! l>ge v>iety & ext5sive sale ( ^! prep>ations appe> to be ow+ to ! fact t physicians d n recall ! ord9>y facts ( *emi/ry1 b accept too readily ! /atem5ts ( ! manufactur]s4 ,,progress ,,9 ,,ph>macy4 ,a ,,qu>t]ly ,,review ,,( ,,"s ,,( ,,! ,,m ,,important ,,advances ,,9 ,,ph>macy ,,& ,,mat]ia ,,m$ica4 ,,by ,m4 ,i4 ,,wilb]t1 ,apo!c>y at ! ,g]man ,hospital1 ,philadelphia1 ,pa4 ,! ,food & ,drugs ,act1 ,june #cj1 #aijf1 cont9ues to be ! lead+ topic = discussion 9 ph>maceutical j\rnals & 9 ph>maceutical circles g5]ally4 ,9 _m ( ! l>g] cities special meet+s h be5 held at :i* ! probable effect ( ! law1 directly z well z indirectly1 on ! sev]al bran*es ( ph>macy h be5 discuss$ at l5g?4 ,:olesale druggi/s & manufactur+ ph>maci/s appe> to be he>tily 9 favor ( ! und]ly+ pr9ciples & ( ! g5]al provisions ( ! ,f$]al pure food & drug law1 despite ! fact t x has impos$ an enorm\s am\nt ( additional "w & exp5se = :i* !y c sc>cely expect to be adequately recomp5s$4 ,! proposition to endorse ! ,f$]al law1 by correspond+ laws 9 ! sev]al ,/ates1 has ar\s$ consid]able opposition on ! "p ( retail ph>maci/s1 :o appe> to be ei!r indiff]5t or else fe>ful le/ ! additional obligations t w\ld be impos$ on !m might be too exact+ or else involve an undue am\nt ( "w or exp5se to comply )4 ,9 ?is connection we %\ld rememb] t ph>maci/s1 z su*1 h tak5 little or no "p 9 secur+ ! enactm5t ( ! ,f$]al pure food & drug law1 & t1 z a consequ5ce1 !y h ?us sacrific$ no little ( _! pr(essional indep5d5ce & pre/ige4 ,?is apa?y on ! "p ( ph>maci/s is ev5 n[ be+ tak5 advantage ( by memb]s ( bo>ds ( heal?1 ,food & ,dairy ,commission]s & well-mean+ b frequ5tly mis9=m$ re=m]s :o are actively at "w to secure food & drug legislation along ! l9es ( ! ,national law4 ,9 by f> ! great] numb] ( ,/ate legislatures1 n[ 9 session1 bills = laws ( ?is k9d h be5 introduc$1 & :e!r enact$ into laws or n1 w t5d to %[ ! wants or desires ( retail ph>maci/s1 &1 if oppos$ or ignor$1 w s]i\sly reflect on ! ability & pr(essional dis9t]e/$ness ( ph>maci/s !mselves4 ,retail ph>maci/s %\ld1 & if !y desire to ma9ta9 _! /&+ 9 ! community !y mu/1 favor pure food & drug legislation t is design$ to protect ! public4 ,by !mselves tak+ an active int]e/ 9 ! secur+ ( legislation along ^! l9es !y c\ld readily prev5t ! enactm5t ( ill-advis$ measures t w\ld t5d to hamp] or re/rict !m 9 ! pursuance ( _! bus9ess4 ,t ! m$ical pr(ession 9 all sections ( ! c\ntry is cle>ly 9 favor ( pure food & drug legislation 0 pla9ly evid5c$ at ! ,conf]5ce ( ! ,committee on ,m$ical ,legislation1 ( ! ,am]ican ,m$ical ,association1 ) ! ,national ,legislative ,c\ncil1 held at ,wa%+ton1 ,d4,c41 ,decemb] #ac? to #ae? inclusive4 ,/ate legislation 0 discuss$ at "s l5g? & ! repres5tatives ( ! sev]al ,/ate ,m$ical ,associations :o 7 pres5t express$ !mselves 9 no unc]ta9 way z be+ 9 favor ( ! individual ,/ates endors+ ! ,f$]al ,food & ,drugs ,act4 ,! proce$+s ( ?is conf]5ce h be5 publi%$ 9 pamphlet =m1 compris+ sixty-eight pages ( closely pr9t$ mat]ial4 ,?is pamphlet conta9s mu* t is ( int]e/ to ph>maci/s1 & may be obta9$ f ! ,secret>y ( ! ,bureau ( ,m$ical ,legislation ( ! ,am]ican ,m$ical ,association1 #ajc ,de>born ,av5ue1 ,*icago1 ,ill4 ,! available lit]ature on pure food & drug legislation is rapidly assum+ huge proportions4 ,9 addition to ! lib]al space t is devot$ to ! "q 9 ! curr5t numb]s ( ph>maceutical j\rnals1 a numb] ( repr9ts ( mat]ial ( ?is k9d h appe>$4 ,n ! lea/ int]e/+ ( ^! repr9ts is a pamphlet ( sixty-f\r pages entitl$3-- ,! ,food & ,drug ,act z x relates to drugs1 exam9$ & expla9$ 9 connection ) ! rules & regulations = its en=cem5t4 ,?is pamphlet is publi%$ by ! ,national ,druggi/1 ,/4 ,l\is1 ,mo41 & conta9s 9 addition to ! law itself & ! regulations p]ta9+ to x1 a numb] ( int]e/+ decisions & mu* additional mat]ial be>+ m or less directly on ! prop] int]pretation ( ! ,food & ,drugs ,act4 ,dige/ ( ,national ,food & ,drugs ,act & ,regulations1 by ,mahlon ,n4 ,kl9e1 is ! title ( a pamphlet conta9+ upw>ds ( sev5ty-two pages t has rec5tly be5 s5t out ) ! complim5ts ( ! ,smi?1 ,kl9e1 ,fr5* ,company1 ,philadelphia4 ,9 addition to a transcript ( ! ,food & ,drugs ,act1 & ( ! rules & regulations = ! en=cem5t ( ! same1 ?is pamphlet also conta9s a numb] ( additional op9ions1 replies & explanations t h be5 publi%$ f "t to "t2 also a legal exposition ( ! ,food & ,drugs ,act by ,george ,l4 ,d\glas1 attorney = ! ,propriet>y ,association ( ,am]ica2 extracts f ! rec5tly publi%$ 8,/&>d ( ,purity = ,food ,products10 & mu* additional in=mation ( int]e/ to retail ph>maci/s4 ,! ,ladies' ,home ,j\rnal ,bill1 or a correspond+ measure to regulate ! manufacture & sale ( s-call$ pat5t m$ic9es1 has be5 introduc$ 9 upw>ds ( t5 ( ! ,/ate legislatures n[ 9 session4 ,?is bill1 orig9ally publi%$ 9 ! ,ladies' ,home ,j\rnal ab\t a ye> ago1 is ess5tially a =mula on ! label bill & provides1 9 addition1 t prep>ations conta9+ "o or m ( c]ta9 specifi$ drugs be label$ poison4 ,anti-n>cotic legislation is also receiv+ a fair proportion ( att5tion4 ,! mo/ dra/ic ( ^! measures is probably ! "o t has be5 introduc$ into ! legislature ( ! ,/ate ( ,new ,york1 at ! in/ance ( ! ,ev5+ ,j\rnal4 ,?is bill prohibits ! sale ( opium1 *loral1 coca9e1 euca9e or acetanilid1 or any prep>ation conta9+ !m1 except on ! orig9al writt5 prescription ( a physician1 d5ti/ or vet]9>ian4 ,9 sev]al ,/ates1 notably ,texas & ,miss\ri1 bills are p5d+ t are design$ to improve or to revise ! laws gov]n+ ! practice ( ph>macy4 ,pat5t ,re=m ,bill4--,repres5tative ,curri]1 ,*airman ( ! ,h\se ,committee on ,pat5ts1 has introduc$ a bill to sub/itute ! mu* discuss$ ,mann bill4 ,?is bill1 popul>ly kn[n z ! ,curri] bill1 is practically a revival ( ! reciprocity feature ( ! orig9al ,mann bill1 b is n re/rict$ to m$ic9e1 or m$ic9al products & includes pat5ts ( all k9ds4 ,! ,curri] bill provides3 8,t any pat5t issu$ to a citiz5 or subject ( a =eign c\ntry1 %all be ^u ! same conditions & = ! same t]m z are pat5ts issu$ by su* c\ntry to citiz5s ( ! ,unit$ ,/ates40 ,?is s+le provision1 x is said1 w\ld effectually correct ! evils aris+ f our pres5t sy/em ( process & product pat5ts1 b w\ld be contr>y to ! t]ms ( ! ,int]national ,conv5tion = ! protection ( indu/rial prop]ty & w no d\bt be vigor\sly oppos$ on ?is gr\nd4 ,incorporation ( ! ,public ,heal? ,def5se ,league4 ,a bill has be5 introduc$ into ! ,legislature ( ! ,/ate ( ,new ,york provid+ = ! incorporation ( ! ,public ,heal? ,def5se ,league1 "u a special *>t] patt]n$ aft] t ( ! ,r$ ,cross ,society4 ,! object ( ?is new society is ann\nc$ z be+ an organiz$ movem5t aga9/ m$ical & surgical quacks1 frauds 9 pat5t m$ic9es or no/rums1 & an ef=t to obta9 & to dissem9ate accurate in=mation conc]n+ practices & conditions ( e k9d t are dang]\s to ! public heal? & morals4 7,j\rnal ,a4 ,m4 ,a41 #aijg1 page #bcf47 ,sunday ,re/ 9 ,france4--,ph>maci/s 9 ,france are n alone adapt+ !mselves to ! rec5tly enact$ ,sunday ,re/ ,law1 b are ev5 go+ f>!r & are adopt+ e>li] h\rs = clos+ dur+ ! week4 ,at ,gr5oble1 :]e ,sunday clos+ has be5 9 vogue = "s "t1 ! ph>maci/s h decid$ to close at #h ,p4,m4 daily & to organize a night s]vice by rotation4 ,! syndicate ( ,p>is ph>maci/s recomm5ds t its memb]s adopt #i ,p4,m4 z ! h\r = clos+ dur+ ! week & to close f midday till ! foll[+ morn+ on ,sundays & bank holidays4 7,*em4 & ,drug41 #aijf1 page #gge47 ,popul>ity ( ,pa/eur 9 ,france4--,! ,petit ,p>isi5 has tak5 a r int]e/+ plebiscite z to :o is ?\ght to be ! greate/ ( n9ete5? c5tury ,fr5*m54 ,9 ! vot+ ,pa/eur took ! lead f ! fir/1 foll[$ by ,victor ,hugo1 ,gambetta1 ,napoleon ,i1 ,?i]s & ,laz>e ,c>not1 9 ! ord] nam$4 7,*em4 & ,drug41 #aijg1 page #f47 ,doses 9 ! ,codex4--,! ,codex ,revision ,committee has decid$ to include a li/ ( maximum doses 9 a supplem5t to ! ,codex1 & has delegat$ ! "w ( draw+ up su* a li/ to a special committee includ+ ,,mm4 ,laud\szy1 ,m>ty1 ,b\rquelot1 ,gilb]t & ,yvon4 7,*em4 & ,drug41 ,dec41 #aijf1 page #hhd47 ,! ,druggi/s' ,circul> has r\nd$ out a half c5tury ( its exi/5ce4 ,! ,janu>y1 #aijg1 numb] ( ?is j\rnal con/itutes a fiftie? anniv]s>y numb] & comprises a total ( #cbj pages4 ,! #aij or m pages t are devot$ to read+ matt] conta9 q an exhau/ive review ( ,am]ican ph>macy dur+ ! pa/ fifty ye>s4 ,all ( ! m int]e/+ articles are lib]ally illu/rat$ & ! numb] itself w no d\bt be appreciat$ z an album ( m5 :o h contribut$1 or are n[ contribut+1 to ! developm5t ( ! sci5ce ( ph>macy 9 ,am]ica4 ,incompatibility ( ,peps9 & ,pancreat9 9 liquid prep>ations4--,a report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ( ! ,am]ican ,m$ical ,association 7,j\rnal ,am]ican ,m$ical ,association1 ,febru>y #b1 #aijg1 p4 #dcd7 calls r5ew$ att5tion to ! g5]ally well-kn[n fact t despite ! frequ5tly made /atem5t t peps9 & pancreat9 mu/ be incompatible 9 liquid prep>ations a numb] ( su* mixtures are /ill be+ (f]$ by manufactur]s or retail ph>maci/s & are us$ by physicians4 ,! ,c\ncil has inve/igat$ a numb] ( prep>ations ( ?is type & has inv>iably f\nd !m to be practically in]t 9 at lea/ "s ( ! claims made = !m4 ,hav+ demon/rat$ t peps9 & pancreat9 _c exi/ 9 "o & ! same solution = any reasonable l5g? ( "t & t prep>ations t are said to conta9 ^! two f]m5ts are sold "u impossible claims1 ! ,c\ncil recomm5ds3 7#a7 ,t ! ,c\ncil on ,ph>macy & ,*emi/ry refuse to approve liquid prep>ations t are claim$ to conta9 bo? peps9 & pancreat94 7#b7 ,t ! m$ical pr(ession ?r\gh ! ,j\rnal ( ! ,am]ican ,m$ical ,association be advis$ ( ! fallacy ( employ+ su* comb9ations4 7#c7 ,t ! att5tion ( manufactur]s be call$ to ! wor?lessness ( su* incompatible liquid prep>ations ( peps9 & pancreat9 & t !y be urg$ to cease (f]+ su* products to ! pr(ession4 7#d7 ,t s9ce ! ,national ,=mul>y has recogniz$ a prep>ation ( ?is k9d "u ! title 8,elixir ,dige/ivum ,compositum0 ! ,am]ican ,ph>maceutical ,association be reque/$ to in/ruct its committee on ! ,national ,=mul>y to omit ?is prep>ation f ! next edition4 ,acetanilid ,mixtures4--,! mixtures ( acetanilid & o!r +r$i5ts t =m]ly 7 exploit$ z def9ite *emical comp\nds are n[ be+ m>ket$ z mixtures1 &1 9 "s cases at lea/1 h _h _! composition *ang$ s z to be totally unrecognizable4 ,antikamnia1 "u ! regulations ( ! ,pure ,food & ,drugs ,act1 is be+ m>ket$ z a mixture conta9+ #cej gra9s ( acetph5etid9 9 ea* ounce4 ,ph>maci/s :o are 9 ! habit ( fill+ prescriptions = physicians call+ = 8antikamnia0 9 solution w n[ exp]i5ce ! additional difficulty ( be+ oblig$ to expla9 :y ! new antikamnia diff]s f ! old 9 its physical prop]ties4 ,ammonol4--,?is prep>ation is said to be ,ammoniumph5ylacetamid on "o portion ( its label & directly "u x is said to conta9 #bdj gra9s ( p>acetyl-ph5etid9 9 ea* ounce4 ,ph5alg91 m>ket$ z an ammoniat$ ph5ylacetamide1 is label$ z conta9+ #ej p] c5t4 ( acetanilidum4 ,b5zosal94--,me?yl b5zoyl salicylate occurs z a :ite cry/all9e p[d] hav+ a slight aromatic odor & ta/e4 ,! sub/ance melts at f #hd to #he ,c4 ,x is ne>ly insoluble 9 wat]1 b is soluble 9 #ce p>ts ( alcohol & is readily soluble 9 *lor(orm b some:at less s 9 e!r4 7,ph>4 ,c5tralh41 #aijf1 p4 #ajec47 ,borov]t94--,?is is ! "n t has be5 appli$ to hexame?yl5e tetram9e triborate4 ,! sub/ance occurs z a yell[i% :ite p[d] readily soluble 9 wat] & hav+ a di/9ctly bitt] ta/e4 ,x may be giv5 9 doses ( f #a to #d grammes daily4 7,ph>4 ,c5tralh41 #aijf1 p4 #ibh47 ,ca/or oil 9 =m ( p[d]4--,a rec5tly issu$ ,g]man pat5t describes a process = prep>+ a suppos$ly active prep>ation ( ca/or oil 9 p[d] =m4 ,?is is accompli%$ by ! addition ( light calc9$ magnesia to an emulsion ( ca/or oil1 or by add+ a specific quantity ( ca/or oil to ! same weight ( calc9$ magnesia t has be5 moi/5$ ) di/ill$ wat]1 & dry+ ! result+ mixture & p[d]+ ! residue4 7,ph>4 ,c5tralh41 #aijg1 p4 #fe47 ,cy/opur94--,?is is said to be a comb9ation ( "o molecule ( hexame?yl5e tetram9e ) two molecules ( sodium acetate4 ,x occurs z :ite1 ne>ly ta/eless cry/als t are readily soluble 9 ei!r hot or cold wat]4 ,cy/opur9 may be adm9i/]$ 9 doses ( #a or #b grammes ?ree times a day4 7,ph>4 ,zeit41 #aijg1 page #dh47 ,=g594--,?is is said to be tetra me?yl ammonium =miate & responds to all ( ! kn[n reactions = =mic acid comp\nds4 ,x is be+ recomm5d$1 9 small doses1 z a he>t tonic4 7,ph>4 ,zeit41 #aijg1 page #dh47 ,levur9ose is a "n giv5 to a yea/ t has be5 desiccat$ by means ( a curr5t ( cold air s z to pres]ve ! individual yea/ cells intact4 ,?is prep>ation has be5 recomm5d$ to be us$ 9 affections ( ! sk91 su* z acne1 eczema1 furunculosis1 urtic>ia1 etc4 7,ph>4 ,zeit41 #aijg1 page #dg47 ,mi/ura ,/rzyz[ski is ! =midable "n1 appli$ 9 ,au/ria1 to a mixture conta9+ f]ric pyrophosphate1 qu99e hydro*loride & sodium bromide4 ,?is mixture is direct$ to be prep>$ z foll[s3-- ,sodium bromide #hjj is dissolv$ 9 di/ill$ wat]1 #djjj2 syrup ( orange peel1 #bjjj2 alcohol1 #ajjj4 ,mix & add a solution ( qu99e hydro*loride1 #ajj 9 di/ill$ wat]1 #djjj2 & syrup ( orange peel1 #bjjj4 ,mix1 & !n add ! foll[+1 prep>$ by slightly w>m+3 ,f]ric pyrophosphate ) ammonium citrate1 #djj 9 di/ill$ wat]1 #djjj4 ,mix1 & add syrup ( orange peel1 #djjj4 ,dose1 "o to two teaspoonfuls1 ) wat]1 two or ?ree times a day4 ,novaspir9 is ! "n appli$ to me?yl citric acid e/] ( salicylic acid4 ,x occurs z a :ite p[d] hav+ a slightly acid ta/e4 ,x is ne>ly insoluble 9 wat] b is readily soluble 9 alcohol4 ,novaspir9 may be giv5 9 doses ( #a gramme ?ree times a day4 7,ph>4 ,zeit41 #aijg1 page #i47 ,qu99e ,phyt9ate4--,anhydro oxyme?yl5e diphosphate ( qu99e occurs z a yell[ p[d]1 v soluble 9 wat] b almo/ insoluble 9 alcohol1 e!r1 b5z9 or *lor(orm4 ,! sub/ance conta9s #eg p] c5t4 ( qu99e & has an int5sely bitt] ta/e4 ,sc>lat9 ,m>pman is an antitox9 prep>ation t1 giv5 int]nally1 is be+ us$ z a prophylactic = sc>let fev]4 ,x is said to be produc$ by inoculat+ animals ) infecti\s mat]ial f sc>let fev] pati5ts & inoculat+ o!r animals ) ! s]um tak5 f ! fir/4 ,! s]um f ! blood ( ! second animal is us$ to immunize o!r animals1 & x is f ^! immuniz$ animals t ! antitox9 s]um is prep>$4 ,sc>lat9 is a yell[i%1 opalesc5t liquid hav+ a slight odor & a salty ta/e4 ,! sub/ance has a specific gravity ( f #ajab to #ajac1 is neutral 9 reaction & gives a copi\s precipitate ) reag5ts = album94 7,ph>4 ,c5tralh41 #aijg1 page #fi47 ,solubility ( ,salic94--,d4 ,b4 ,dott 7,ph>4 ,j\r41 #aijg1 page #gi7 f9ds t ! solubility ( salic91 z giv5 9 ! ,briti% ,ph>macopia 7#a 9 #bh7 is practically correct1 :ile t ( ! ,u4 ,s4 ,p4 7#a 9 #ba at #be ,c47 is too high4 ,us+ pure salic91 t melt$ at #bja ,c41 he f9ds t x has a solubility ( #a 9 #bd at #be ,c41 or v ne>ly t call$ = by ! ,briti% ,ph>macopia at ord9>y temp]atures4 ,sub/itutes = ,coca9e4--,dr4 ,hugo ,w9t]/e9] 7,wi5] ,mea4 ,wo*5s*41 #aijf1 page #acci7 reports a compreh5sive comp>ative /udy ( ! use ( coca9e & its v>i\s sub/itutes 9 eye "w4 ,( ! num]\s sub/ances t h be5 propos$ f "t to "t he describes tropococa91 holoca91 euca91 /ova91 alyp9 & novoca9 at "s l5g? & concludes t :ile x is true t ^! sub/ances are relatively m /able ?an coca91 & are !re=e m readily /]iliz$1 ! num]\s objectionable features1 su* z unreliability1 irritat+ prop]ties & ! production ( a hyp]emia1 are s mu* m objectionable t coca9e mu/ be admitt$ to be by f> ! mo/ satisfactory z well z ! safe/ local ane/hetic 9 all v>ieties ( eye "w4 ,tannisol is a r$di%-br[n1 odorless & ta/eless p[d] t is insoluble 9 wat]1 e!r or b5z9e1 b is soluble 9 alcohol & 9 dilute solutions ( alkalies or ( ! alkal9e c>bonates4 ,x is direct$ to be us$ int]nally 9 cases ( inte/9al cat>rh1 & ext]nally = a v>iety ( inflammatory conditions ( ! sk94 ,int]nally x may be giv5 9 doses ( #jej gramme 7,ph>4 ,c5tralh41 #aijf1 page #ajjf74 ,!olact94--,?is "n has be5 appli$ to a d\ble salt ( !obrom9 sodium & sodium lactate4 ,x occurs z a :ite hygroscopic p[d]1 readily soluble 9 wat] & hav+ a di/9ctly bitt] ta/e4 ,x is said to be an active diuretic1 b is n free f occasional side effects 9 ! =m ( ga/ric di/urbances4 7,ph>4 ,zeit41 #aijg1 page #di47 ,t9ctura olea ,europeae4--,a t9cture made ) #fj p] c5t4 alcohol f ! dri$ leaves ( ! ,european olive has be5 us$ z a febrifuge z well z a g5]al tonic 9 place ( ! t9cture ( c9*ona b>k4 ,triacetyl morph94--,?is sub/ance has be5 isolat$ f a mixture ( acetyl d]ivatives ( morph94 ,triacetyl morph9 melts at f #bjf to #bjh ,c41 is only slightly soluble 9 wat] or cold alcohol1 b is readily soluble 9 acids4 ,) hydro*loric acid x =ms a salt t cry/allizes 9 ! =m ( long ne$les4 7,ph>4 ,c5tralh41 #aijf1 page #ibh47 ,tulaselact9 is ! "n giv5 by ,behr+ to a sub/ance t is expect$ to immunize infants aga9/ tub]culosis4 7,ph>4 ,c5tralh41 #aijg1 page #bd47 ,tulase 7,a4 ,j4 ,p41 #aijf1 page #ehb7 is ! "n giv5 by ,behr+ to 8 immuniz+ & curative s]um = tub]culosis4 ,?is prep>ation is said to conta9 all ( ! con/itu5ts ( ! ,ko* bacillus4 ,x occurs z a cle> fluid :i* has ! g5]al outw>d *>act]i/ics ( ?9 honey4 ,x may be giv5 subcutane\sly1 intrav5\sly or by m\?4 ,! mixture ( tulase ) milk1 m5tion$ above1 is ! =m 9 :i* x may be adm9i/]$ to infants4 ,tulase is n[ be+ us$ 9 an exp]im5tal way1 b ,behr+ himself w>ns aga9/ too mu* reliance be+ plac$ on ! curative prop]ties ( ! sub/ance4 ,,correspond5ce4 ,editor ( ! ,,am]ican ,,j\rnal ,,( ,,ph>macy4 ,,de> ,,sir3--,i s5d y h]e) ! result ( ! votes ( ! ,committee ( ,revision ^u ! fir/ in/alm5t ( corrections 9 ! ,u4 ,s4 ,ph>macopia1 eigh? revision1 s9ce ! passage ( ! ,food & ,drugs ,act4 ,v truly y\rs1 ,,joseph ,p4 ,,rem+ton1 ,*airman4 ,,*anges ,,& ,,corrections ,,9 ,,! ,,unit$ ,,/ates ,,ph>macop,,ia4 7,eigh? revision47 ,belladonna ,leaf n[ #jc p] c5t4 mydriatic alkaloids4 ,belladonna ,root n[ #jde p] c5t4 mydriatic alkaloids4 ,col*icum ,se$ n[ #jde p] c5t4 ( col*ic9e4 ,ipecac n[ #age p] c5t4 ( ipecac alkaloids4 ,/ramonium n[ #jbe p] c5t4 ( mydriatic alkaloids4 ,fluidextract ( ,belladonna ,root n[ #jd gramme alkaloids 9 #ajj c4c4 ,t9cture ( ,belladonna ,leaf n[ #jjc gramme alkaloids 9 #ajj c4c4 ,fluidextract ( ,col*icum ,se$ n[ #jd gramme alkaloid 9 #ajj c4c4 ,t9cture ( ,col*icum ,se$ n[ #jjd gramme alkaloid 9 #ajj c4c4 ,fluidextract ( ,ipecac n[ #ae gramme alkaloids 9 #ajj c4c4 ,fluidextract ( ,/ramonium n[ #jbe gramme alkaloids 9 #ajj c4c4 ,extract ( ,/ramonium n[ #aj p] c5t4 alkaloids4 ,t9cture ( ,/ramonium n[ #jjbe gramme alkaloids 9 #ajj c4c4 ,jalap ,root n[ #g p] c5t4 ( total res94 ,"u ! article ,petrolatum1 p4 #ccf1 ,u4 ,s4 ,p41 la/ p>agraph1 ! sulphuric acid te/ has be5 dropp$4 ,febru>y #ae1 #aijg4 ,,book ,,reviews4 ,,elem5ts ,,( ,,g5]al ,,*emi/ry ,,) ,,exp]im5ts4 ,by ,john ,h4 ,long1 ,m4,s41 ,sc4,d41 ,pr(essor ( ,*emi/ry & ,director ( ! ,*emical ,laboratories 9 ! ,nor?we/]n ,univ]sity ,m$ical ,s*ool4 ,f\r? edition1 revis$ & enl>g$4 ,illu/rat$4 ,philadelphia3 ,p4 ,blaki/on's ,son ,co41 #aijf4 ,t ,pr(essor ,long 0 m ?an ju/ifi$ 9 writ+ ?is textbook is %[n by ! fact t s9ce ! appe>ance ( ! fir/ edition 9 #ahhh two o!r editions h be5 issu$1 & x has be5 necess>y n[ to issue a f\r? edition4 ,! "t has gone by 9 all ( ! sci5ces :5 x c be said t a /ud5t is acqua9t$ ) fundam5tal pr9ciples unless he has repeat$ "s ( ! classroom "w 9 ! laboratory4 ,z ,dr4 ,long well says3 8,repetition is necess>y to fix elem5t>y pr9ciples ?or\ghly 9 ! m9d ( ! beg9n]40 ,! pres5t edition conta9s "s additional matt] on ! !ories ( solution1 ! conditions ( *emical equilibrium1 "s new] views ( *emical !ory & ! description ( sev]al new sub/ances4 ,! book is a rem>kably good "o = ! beg9n]1 & is well adapt$ to ! ne$s ( ! ,fre%m5 class 9 any ( ! colleges :]e a g5]al c\rse 9 inorganic *emi/ry is giv54 ,,*emical ,,ab/racts4 ,publi%$ by ! ,am]ican ,*emical ,society4 ,vol4 ,i1 ,nos4 #a & #b4 ,ea/on1 ,pa43 ,! ,*emical ,publi%+ ,co4 ,janu>y #a & #bj1 #aijg4 ,"u ?is title ! ,am]ican ,*emical ,society has begun ! publication ( an indep5d5t semi-mon?ly p]iodical :i* %all furni% to ,am]ican *emi/s at %ort int]vals a full & compreh5sive s]ies ( ab/racts cov]+ ! :ole range ( pure & appli$ *emical sci5ce toge!r ) ! titles ( ,am]ican1 ,briti%1 ,fr5* & ,g]man pat5ts on *emical subjects4 ,! importance & value ( ?is und]tak+ c h>dly be ov]-e/imat$4 ,! ,j\rnal ( ! ,engli% ,*emical ,society has long cov]$ some:at simil> gr\nd1 b h>dly 9 ! complete mann] t our ,am]ican society has n[ attempt$2 ! ,j\rnal ( ! ,society ( ,*emical ,indu/ry has always made a feature ( its ab/racts & pat5t ref]5ces1 b ^! cov] appli$ *emi/ry only2 ! ,g]man ,*emical ,society "s ye>s ago took ov] ! publication along ) its ,b]i*te ( ! ,*emis*e ,c5tralblatt = ?is same purpose ( furni%+ a complete s]ies ( ab/racts1 b x 0 felt t our ,am]ican ,*emical ,society %\ld take up ?is "w = its own memb]%ip1 n[ numb]+ ov] #cjjj *emi/s4 ,s ! ,society = ! future w publi% its ,j\rnal z a mon?ly = orig9al pap]s & communications1 ( :i* x has z _m z x c possibly f9d room = 9 its twelve issues1 & ! ,ab/ract ,j\rnal z a semi-mon?ly1 cov]+ ! :ole field ( pure & appli$ *emi/ry "u "s #cj subdivisions1 ( :i* ph>maceutical *emi/ry is "o4 ,t ?is subject w be c>$ = 9 an appreciative & intellig5t way c be assum$1 z we note t ,pr(4 ,a4 ,b4 ,/ev5s ( ,ann ,arbor is 9 *>ge ( ! ab/racts 9 ?is field4 ,= ^? :o are n memb]s ( ! ,society ! subscription price is z foll[s3 ,j\rnal ( ! ,am]ican ,*emical ,society1 mon?ly1 #f2 ,*emical ,ab/racts1 semi-mon?ly1 #f2 = bo? j\rnals s5t to ! same subscrib]1 #aj4 ,memb]s ( ! ,am]ican ,*emical ,society receive bo? j\rnals = ! annual memb]%ip fee ( #h4 ,s4 ,p4 ,,sadtl]4 ,,! ,,philadelphia ,,bran* ,,( ,,! ,,am]ican ,,ph>maceutical ,,association4 ,! regul> /at$ meet+ ( ! ,philadelphia ,bran* ( ! ,am]ican ,ph>maceutical ,association 0 held on ! ev5+ ( ,friday1 ,janu>y #d1 #aijg1 & 0 att5d$ by #fc memb]s & visitors4 ,! m9utes ( ! previ\s meet+ 7 read & decl>$ approv$4 ,! ,committee on ,sunday ,clos+ & ! ,committee on ,/ate ,legislation made prelim9>y reports t 7 receiv$ & ord]$ fil$4 ,on behalf ( ! ,committee on ,/ate ,legislation ,mr4 ,cliffe said t memb]s ( ! committee _h _h an opportunity to conf] ) ! memb]s ( a special committee ( ! ,/ate ,legislature on ! subject & t a jo9t conf]5ce ( memb]s ( committees int]e/$ 9 ! enactm5t ( a ,/ate ,food & ,drug ,law w\ld be held at ! ,philadelphia ,college ( ,ph>macy on ! ev5+ ( ,tuesday1 ,janu>y #ae1 #aijg4 ,! regul> program = ! ev5+ 0 !n proce$$ )4 ,?is consi/$ ( a discussion ( 8,! ,debas+ ,influ5ces ( ,fraudul5t ,no/rums40 ,! fir/ communication1 by ,dr4 ,solomon ,solis ,coh51 0 devot$ to ! consid]ation ( 8,secrecy & ,fraud z ,det]r+ ,factors to ! ,progress ( ,m$ic9e40 ,dr4 ,coh51 9 ! c\rse ( 8 rem>ks1 said t progress means an asc5t f little or no k to k1 & f k to great] k4 ,secrecy is ! )hold+ ( k & bre$s ignorance1 :ile fraud is ev5 worse ?an ignorance 9 t x is design$ to mislead4 ,dr4 ,coh5 also ass]t$ t !rapeutics 0 difficult en\gh "u ! mo/ favorable conditions & t 9 cases :]e a physician is confront$ ) secrecy or fraud1 9 ! /atem5ts made 9 connection ) m$ic9al prep>ations1 he is likely to be misl$ himself & to d untold h>m to 8 pati5ts4 ,9 conclud+1 ! speak] ref]r$ to a numb] ( specific prep>ations :i* h be5 discov]$ to diff] mat]ially 9 composition f :at 0 claim$ = !m4 ,he also express$ ! hope t ! ,f$]al ,pure ,food & ,drugs ,law w\ld be in/rum5tal 9 lead+ manufactur]s to m duly appreciate ! ne$ = a great] degree ( hone/y 9 ! exploitation ( _! w>es4 ,if ph>macy is to make progress & if m$ic9e is to make progress x w necessitate a full & complete k ( ! composition & action ( ! sub/ances us$ 9 ! treatm5t ( diseases4 ,! next communication1 by ,dr4 ,h5ry ,leffmann1 dealt )3 8,kn[n & ,unkn[n ,*anges 9 ! ,composition ( well-kn[n ,no/rums40 ,dr4 ,leffmann said t ! "q ( secrecy 0 "o ( ! mo/ intricate problems & "o t involv$ a numb] ( factors4 ,secrecy 9 connection ) no/rums1 ! composition ( :i* 0 kn[n only to "s "o or m individuals1 b n to all 0 an objectionable feature & frequ5tly l$ to arbitr>y & 9 _m in/ances dang]\s *anges 9 ! composition & ! action ( no/rums4 ,dr4 ,leffmann !n call$ att5tion to a numb] ( specific in/ances 9 :i* x 0 kn[n t *anges _h be5 made 9 ! composition ( widely adv]tis$ no/rums & also po9t$ out h[ ^! *anges might be injuri\s to ! consum]4 8,crim9al ,responsibility 9 ! ,sale ( ,abortifaci5ts0 0 ! subject matt] ( ! communication by ,dr4 ,h5ry ,beates1 ,jr4 ,dr4 ,beates ref]r$ to ! v>i\s /atutes relat+ to ! use1 sale or di/ribution ( abortifaci5ts & condemn$1 9 no unc]ta9 t]ms1 ! practice ( adv]tis+1 9 lay j\rnals1 articles design$ to prev5t conception or to produce abortion4 ,he held t additional publicity might well be giv5 to ! s]i\s nature ( ! que/ions involv$1 & urg$ t /eps be tak5 to prev5t ! use ( ! ,unit$ ,/ates mails by newspap]s & magaz9es publi%+ adv]tisem5ts ( abortifaci5ts or ( in/rum5ts design$ to prev5t conception4 ,dr4 ,john ,b4 ,rob]ts1 9 op5+ ! g5]al discussion ( ! "q1 ass]t$ t !re c]ta9ly c\ld be no diff]5ce ( op9ion on ! degrad+ influ5ces ( practices t1 z _h be5 %[n by ! previ\s speak]s1 t5d$ to conv]t ph>maci/s & ph>maceutical manufactur]s into li>s & m$ical practition]s into frauds & fakirs4 ,! subject matt] 0 fur!r discuss$ by ,dr4 ,h5ry ,w4 ,cattell1 ,dr4 ,f4 ,e4 ,/ew>t1 ,dr4 ,c4 ,b4 ,l[e & ,messrs4 ,rem+ton1 ,la,wall1 ,turn]1 ,?um1 ,b]+]1 ,v&]kle$1 ,cable1 ,we/cott1 ,wilb]t & ,cliffe4 ,mr4 ,cliffe pres5t$ ! foll[+ resolutions1 :i*1 on motion1 7 unanim\sly adopt$3 ,resolv$ t ! ,philadelphia ,bran* ( ! ,am]ican ,ph>maceutical ,association condemns ! adv]tisem5t 9 drug j\rnals1 magaz9es & newspap]s ( abortifaci5t m$ic9es & deprecates _! sale by reputable ph>maci/s4 ,resolv$ t all memb]s ( ?is bran* be urg$ to exclude su* m$ic9es & articles f _! /ocks4 ,! secret>y !n read a communication entitl$ 8,objectionable ,side ,l9es to ! ,practice ( ,m$ic9e10 specifically m5tion+ sev]al pr(it-%>+ & /ock-di/ribut+ s*emes t are n[ do+ bus9ess 9 ! city ( ,philadelphia4 ,?is communication 01 on motion1 direct$ to be =w>d$ to ! ,secret>y ( ! ,philadelphia ,c\nty ,m$ical ,society ) ! (f] to submit additional evid5ce to ! (ficials ( t organization4 ,!re be+ no fur!r bus9ess ! meet+ 0 decl>$ adj\rn$4 ,,febru>y ,,meet+4 ,! regul> /at$ meet+ ( ! ,philadelphia ,bran* ( ! ,am]ican ,ph>maceutical ,association 0 held on ! ev5+ ( ,tuesday1 ,febru>y #e1 #aijg1 9 ! ,hall ( ! ,college ( ,physicians4 ,! subject "u discussion1 8,high] ,educational ,requirem5ts = ,ph>maci/s10 has attract$ consid]able att5tion dur+ ! pa/ ye> or m1 & x 0 !re=e n surpris+ to f9d t retail ph>maci/s att5d+ ?is meet+ 7 comp>atively well in=m$ on que/ions relat+ to education1 & fully appreciat$ ! ne$ = m rapid advancem5t along educational l9es 9 ! future4 ,! fir/ speak] on ! subject1 ,mr4 ,william ,l4 ,cliffe1 9 discuss+ 8,! ,practical ,ne$s = ,high] ,education 9 ,ph>macy10 call$ att5tion to ! fact t ! p at l>ge are rapidly becom+ m ?or\ghly famili>iz$ ) ! ne$s & ! wants ( ! practice ( ph>macy4 ,he believes t ) ! fur!r elim9ation ( empiricism & my/icism f ! sci5ce ( m$ic9e m w be expect$ ( ph>maci/s1 & !y 9 turn w be requir$ to be educat$ 9 e way4 ,pr(4 ,h5ry ,kraem]1 9 speak+ on 8,/&>ds 9 ,ph>maceutical ,education10 7see p4 #aja7 call$ att5tion to ! fact t up to ! pres5t "t ! progress ( ph>macy 9 ?is c\ntry _h be5 comp>atively sl[ & t we are n[ ent]+ on an era ( m rapid developm5t4 ,he believes t ! enactm5t ( pure food & drug laws w add great additional responsibility to ! duties ( ! retail ph>maci/ & w also t5d to m %>ply def9e ! correspond+ duties ( ! colleges & ( ! bo>ds ( ph>macy4 ,dr4 ,horatio ,c4 ,wood1 ,jr41 9 speak+ on 8,! ,future ,elaboration ( a ,c\rse 9 ,ph>macy10 said t1 z a comm]cial pursuit1 ! bus9ess ( ph>macy mu/ necess>ily be "o ( limit$ scope & possibilities2 z a pr(ession1 h[ev]1 ph>macy c be develop$ into an occupation ( laudable aims & high ideals4 ,he believes t ! ph>maci/ %\ld develop z ! assi/ant & ! advis] ( ! physician1 :o 9 turn mu/ dep5d m & m on ! ef=ts ( ! ph>maci/ to select = him & to improve on ! effici5cy ( ! available articles ( ! mat]ia m$ica4 ,pr(4 ,i4 ,v4 ,s4 ,/anislaus1 9 op5+ ! g5]al discussion1 gave x z 8 op9ion t ! ph>maci/ ( ! future w\ld aga9 hold ! same relative position to ! public z did ! apo!c>y ( old4 ,! ph>maci/ ( ! future w be ! *emi/ ( ! p1 ! food & drug analy/1 ! assi/ant & advis] ( ! physician1 9 all matt]s relat+ to mat]ia m$ica & *emi/ry1 & w1 !re=e1 practically be ! sanit>ian ( ! community4 ,! subject 0 fur!r discuss$ by ,messrs4 ,john ,k4 ,?um1 ,frankl9 ,apple1 ,jacob ,epp/e91 ,m4 ,i4 ,wilb]t1 ,h4 ,c4 ,blair1 ,e4 ,full]ton ,cook1 ,john ,hahn & ,dr4 ,f4 ,e4 ,/ew>t4 ,f ! g5]al tr5d ( ?is discussion x 0 pla9ly evid5t t ! bett] in=m$ retail ph>maci/s deeply appreciate _! responsibility to ! public1 & are will+ & ev5 anxi\s to meet _! obligations fully4 ,at no "t 9 ! hi/ory ( ph>macy 9 ?is c\ntry has x be5 s evid5t t ! m5tally & morally poor man %\ld n be all[$ to jeop>dize ! heal? & ev5 ! lives ( 8 fell[ be+s z n[4 ,x is cle>ly evid5t t ph>maci/s are beg9n+ to realize t a full & complete appreciation ( _! duties to society at l>ge mu/ ( necessity react to _! own pecuni>y advantage & w 9 addition procure = !m ! respect & ! admiration ( _! fell[ m54 ,m4 ,i4 ,,wilb]t1 ,secret>y4 ,a ,,review ,,( ,,! ,,opson9s ,,& ,,bact]ial ,,vacc9es4#b ,,by ,e4 ,m4 ,,h\ghton4 ,z reque/$ by ! ,!rapeutic ,gazette1 ,i %all attempt to describe z succ9ctly z possible ! !ory ( ! opson9s & ! !rapeutic results t h be5 obta9$ by ! application ( ! new !ory4 ,z ! ye>s g by we realize m ?or\ghly ! correctness ( ! prophetic belief ( ! 8,immortal ,pa/eur10 t ! day w\ld come :5 x w\ld be possible to eradicate ! infecti\s diseases by vacc9ation4 ,we are indebt$ to ,met*nik(f = call+ att5tion to & expla9+ ! rle ( ! :ite blood cells 9 ! def5ce ( ! body aga9/ bact]ial invasion1 b ! ph5om5on ( phagocytosis is n s simple z x at fir/ appe>$1 z little by little new facts are develop$ :i* amplify our k ( ! subject4 ,x 0 %[n by ,d5ys & ,leclef1 9 #ahie1 t :5 rabbits 7 immuniz$ aga9/ ,/reptococcus pyog5es ! s]um acquir$ b slight bact]icidal prop]ties1 b t su* s]um1 :5 br\ght 9 contact ) ! leucocytes ( normal or immuniz$ rabbits1 greatly enhanc$ _! phagocytic activity4 ,conv]sely no accel]ation ( phagocytosis 0 obs]v$ :5 ! corpuscles 7 br\ght 9 contact ) ! s]um ( a normal animal4 ,m5nes two ye>s lat] confirm$ ?is by %[+ t simil> results 7 obta9$ f ! blood s]um ( gu9ea-pigs treat$ ) cultures or tox9s ( ,pneumococci4 ,a me?od ( measur+ ! phagocytic activity ( ! leucocytes 0 develop$ by ,lei%man 9 #aijb4 ,9 #aijc ,wright & ,d\glas made an ext5sive /udy ( ! phagocytes1 :5 br\ght 9 contact ) susp5sions ( ,/aphylococcus pyog5es1 & 7 able to %[3 7#a7 ,quot+ f ! orig9al3 8,we h "h conclusive pro( t ! blood fluids modify ! bact]ia 9 a mann] :i* r5d]s !m a ready prey to ! phagocytes4 ,we may speak ( ?is z an #8opsonic' effect 7opsono a ,lat9 v]b1 ,i cat] =2 ,i prep>e victuals =71 & we may employ ! t]m #8opson9s' to designate ! elem5ts 9 ! blood fluids :i* produce ?is effect40 7#b7 ,normal blood s]um & plasma possess ! same opsonic action ^u bact]ia4 7#c7 ,s]um loses its opsonic action :5 heat$ to #fj ,c4 ,?is is spok5 ( z inactivat$ s]um4 7#d7 ,inactivat$ s]um & physiological salt solution h ! same influ5ce ^u phagocytosis4 7#e7 8,! opsonic p[] ( ! blood fluids disappe>s gradually on /&+10 los+ ab\t #ej p] c5t4 ( its activity 9 five or six days4 7#f7 ,an anti-opsonic effect is not$ :5 blood s]um is dige/$ ) typhoid bacilli4 7#g7 ,:5 a condition ( immunity is conf]r$ ^u pati5ts infect$ by ,/aphylococci1 by vacc9ation ) heat$ cultures ( ,/aphylococci1 ! opsonic action ( ! pati5t's blood s]um is greatly augm5t$4 ,neufeld & ,rimpau 7#aijd7 f\nd 9 anti/reptococcic & pneumococcic s]a evid5ce ( sub/ances :i*1 :ile inactive t[>ds leucocytes1 possess$ v m>k$ opsonic or s5sitiz+ action1 z !y t]m$ x1 t[>d correspond+ cultures ( /reptococci & pneumococci4 ,ross 7,lancet1 ,novemb]1 #aijf7 summ>izes our k ( ! opson9s z foll[s3 87#a7 ,opson9s act by *emically unit+ ) ! invad+ bact]ia1 & s alt]+ !m t ! leucocytes are able to phagocyte ! bact]ia & de/roy !m4 ,x is important to rememb] t ^! sub/ances d n /imulate or o!rwise affect ! leucocytes4 87#b7 ,x is probable t !re are pres5t _m v>ieties ( opson9s 9 ! blood plasma1 ea* hav+ to d ) combat+ a p>ticul> k9d ( microbic invasion4 87#c7 ,opson9s h be5 %[n to be di/9ct f o!r bact]iotropic sub/ances1 su* z ! bact]iolys9s1 ! agglut99s1 & ! antitox9s40 ,! leucocytes ( heal?y or diseas$ p]sons seem to be equally active :5 br\ght 9 contact ) ! same s]um1 h5ce ! am\nt ( opson9s pres5t 9 ! blood ( an individual det]m9es1 accord+ to ! opsonic !ory1 8 susceptibility to bact]ial invasion4 ,,te*nique4 ,to measure ! resi/ance ( ! pati5t to su* invasion1 or to f9d out 8 opsonic index1 special te*nique has be5 develop$1 :i* may be briefly describ$ z foll[s3 ,i4 ,,emulsions ,,( ,,bact]ia4 ,tw5ty-f\r-h\r or y\ng] gr[?s ( ! rapid-gr[+ bact]ia1 z ,/aphylococci1 ,/reptococci1 ,pneumococci1 ,gonococci & ,colon bacilli1 ^u incl9$ ag> are wa%$ (f ) normal sal9e solution4 ,aft] ! mixture has s$im5t$1 ! upp]1 :iti% lay] compos$ ( fluid & bact]ia is remov$ ) a pipette1 & ! f9] clumps ( bact]ia precipitat$ by plac+ ! fluid 9 a rapidly rotat$ c5trifuge = a few m9utes4 ,! sup]natant lay]1 :i* is /ill opalesc5t & is call$ a bact]ial emulsion1 %\ld if suitable = "w conta9 ! g]ms 9 a well-sep>at$ condition4 ,cultures ( tub]cle g]ms are heat$1 & gr\nd 9 a mort> ) salt solution until ! mass is well brok5 up1 & !n c5trifugat$4 ,9 case glyc]9 cultures are us$1 su* z are left 9 ! manufacture ( ,ko*'s old tub]cul91 ! glyc]9 mu/ be remov$ by repeat$ wa%+ ) wat] & f9ally ) #ae p] c5t4 salt solution4 ,! wa%$ culture is work$ up 9 a mort> & c5trifugat$ until ! clumps are practically all ?r[n d[n1 & ! cl\dy lay] or emulsion is remov$4 ,! emulsions mu/ be ( uni=m d5sity4 ,wright comput$ ! numb] ( g]ms 9 a giv5 volume by c\nt+1 b ,mc,farland & ,l',engle devis$ an app>atus :i* is call$ a nephelomet]1 consi/+ ess5tially ( mixtures ( ,ba,s,o#d1 put up 9 seal$ tubes1 :i* correspond to solutions conta9+ f #a to #aj p] c5t4 ( ,ba,cl#b1 :i* s]ve z /&>ds4 ,! turbidity ( ! emulsion is comp>$ 9 simil> lay] ) ! /&>d tubes ( ,ba,s,o#d4 ,!y f\nd t ! tube conta9+ 8#e p] c5t4 ( ,ba,cl#b corresponds to ! mo/ useful bact]ial susp5sion40 ,! p]man5cy ( ! emulsions v>ies a good deal4 ,susp5sions ( ! gonococci %\ld be us$ at once1 /aphylococci )9 two days1 etc41 :ile ! emulsion ( tub]cle g]ms may be employ$ indef9itely4 ,,ii4 ,,wa%$ ,,:ite ,,blood-,,corpuscles4 ,! f+] or lobe ( ! e> is punctur$ z 9 mak+ a blood c\nt1 & ! blood is all[$ to drop directly into normal sal9e1 #he p] c5t4 solution1 conta9+ ab\t #a p] c5t4 sodium citrate2 ?is decalcifies ! blood & prev5ts clott+4 ,! corpuscles are completely precipitat$ 9 ! c5trifuge1 & !n repeat$ly wa%$ ) #he p] c5t4 sal9e & c5trifugat$1 until all traces ( ! citrate & s]um are remov$4 ,aft] ! f9al precipitation ! sal9e solution is )drawn1 & ! ?9 upp] grayi% lay] ( ! s$im5t1 ! leucocytic cream1 consi/+ = ! mo/ "p ( wa%$ :ite blood cells1 is remov$4 ,,iii4 ,,! ,,s]um4 ,blood is obta9$ 9 ! usual way1 b is collect$ 9 small1 b5t1 glass tubes1 :i* c be readily held 9 ! c5trifuge & ! s]um sep>at$4 ,9 obta9+ normal s]um1 c>e mu/ be ex]cis$ 9 select+ a heal?y subject1 or1 :at is bett]1 obta9 s]um f ! mix$ blood ( sev]al normal p]sons' 8,pool40 ,,iv4 ,,/a94 ,) ! exception ( ,malta fev] & tub]cle bacilli1 ,lei%man's /a91 consi/+ ( eos9 & me?yl5e-blue1 9 comb9ation1 or ,j5n]'s /a91 is employ$4 ,c>bol-fu*s9 is employ$ = ! tub]cle bacilli4 ,,me?od ,,( ,,obta9+ ,,opsonic ,,index4 ,special capill>y pipettes1 graduat$ into equal divisions1 are requir$2 !n by means ( a rubb] tube or bulb equal quantities ( wa%$ corpuscles1 bact]ial emulsion1 & pati5t's s]um are tak5 up1 & all bl[n out ^u a glass slide & ?or\ghly mix$4 ,! mixture is !n drawn up 9 a small pipette1 seal$1 & plac$ 9 an incubator ( ! ord9>y type1 or pref]ably 9 an opsonic incubator z propos$ by ,freeman2 x is heat$ to #cg to #dj ,c4 = fifte5 m9utes4 ,a simil> tube is prep>$1 except t ! normal s]um or 8,pool0 is employ$ in/ead ( ! pati5t's s]um4 ,at ! end ( fifte5 m9utes ! sme>s on microscopical slides are made f ea* tube1 fix$1 & /a9$4 ,a good field is select$1 "o conta9+ _m leucocytes1 ! numb] ( g]ms c\nt$ 9 ! fir/ fifty or hundr$ obs]v$1 & an av]age p] leucocyte det]m9$4 ,if ! av]age 9 ! mixture conta9+ ! normal s]um is two1 we w\ld say t ! normal opsonic index is two1 & if ! mixture conta9+ ! pati5t's blood s]um is "o p] corpuscle1 we w\ld say t 8 index 0 "o-half1 etc4 ,wright & 8 pupils1 z ! result ( num]\s obs]vations1 classify diseases due to bact]ial infections3 7#a7 8,diseases 9 :i* ! bact]ial process is /rictly localiz$0 or 8%ut (f f ! lymph & blood circulations40 ,furunculosis1 lupus1 tub]culosis1 etc41 9 fact mo/ *ronic infections1 belong to ?is class4 8,9 ?is class ! opsonic index ( ! blood is p]si/5tly bel[ normal1 ow+ to ! abs5ce ( immuniz+ /imuli40 7#b7 8,diseases 9 :i* ! bact]ial process is b loosely %ut (f1 especially f ! lymph circulation40 ,9 ^!1 usually acute1 infections immuniz+ products f ! invad+ bact]ia f "t to "t get into ! circulation1 & ! opsonic index may be normal or above or bel[ normal4 ,good examples ( ?is class are tub]cul\s jo9ts1 etc4 7#c7 8,diseases 9 :i* ! bact]ial infection is 9 ! blood /ream40 ,9 ?is class belong acute infecti\s diseases1 septicemia1 endoc>ditis1 ,malta fev]1 etc4 ,9 ^! 8! opsonic index is g5]ally bel[ normal40 ,wright & ,d\glas lay d[n ! foll[+ g5]al pr9ciples = treat+ cases ( bact]ial infections3 7#a7 8,isolate 9 pure culture ! causative microrganism40 7#b7 8,e/imate ! opsonic p[] ( ! pati5t's blood to ?is microrganism40 7#c7 8,if ! opsonic index be at or bel[ normal1 prep>e & /&>dize a vacc9e f ?is microrganism40 7#d7 8,inoculate ! pati5t ) ?is vacc9e ) appropriate doses & at prop] int]vals1 z %[n by a sy/ematic e/imation ( ! opsonic cont5t ( ! pati5t's blood40 ,,prep>ation ,,( ,,vacc9es4 ,! vacc9es1 ) ! exception ( ! tub]cle vacc9e1 consi/ ( emulsions ( heat$ cultures ( ! p>ticul> g]m produc+ ! infection4 ,luxuriant cultures ( ! desir$ organism are gr[n ^u incl9$ ag>2 ! gr[? is !n remov$ ) salt solution & a glass rod1 & ?or\ghly emulsifi$ by %ak+ 9 a te/-tube1 9 ord] to get ! g]ms well di/ribut$ & ! clumps brok5 up4 ,! numb] ( g]ms 9 a giv5 quantity ( ! emulsion is !n det]m9$ by comp>+ ! numb] ( g]ms & r$ blood-corpuscles 9 a mixture ( "o "p emulsion1 "o "p fre%ly drawn blood1 & ?ree p>ts ( normal salt solution4 ,if !re are t5 times z _m g]ms z blood-corpuscles1 ! bact]ial susp5sion conta9s approximately #de1jjj1jjj g]ms p] cubic c5timet]4 ,! numb] ( g]ms pres5t w ( c\rse v>y ) ! d5sity ( ! emulsion4 ,! bact]ial susp5sion is heat$ at ! l[e/ temp]ature & = ! %orte/ possible "t to kill x4 ,! am\nt ( /]ilization w diff] ) diff]5t organisms2 #fj ,c4 or less ma9ta9$ = ?irty m9utes or less is usually suffici5t4 ,cultures f ! vacc9e are f9ally made to insure t x is /]ile & safe & "s pres]vative add$4 ,tub]cle ,vacc9e4--,?is is ! 8,new ,tub]cul9 ,ko*10 an opalesc5t fluid1 conta9+ ! active pr9ciple ( tub]le bacilli obta9$ accord+ to ! me?od ( ,ko*4 ,,!rapeutic ,,application4 ,aft] a prop] diagnosis has be5 made1 ! pati5t's opsonic index tak51 & ! appropriate vacc9e prep>$1 ! pati5t receives 8 initial injection ( sev]al hundr$ millions m or less ( ! heat$ bact]ia1 & 8 opsonic index is wat*$4 ,a %ort "t aft] ! inoculation is made ! opsonic index falls l[] ?an x 0 previ\s to ! injection4 ,?is ,wright has nam$ ! 8negative phase40 ,soon] or lat]1 f a few h\rs to sev]al days1 ! opsonic index rises above ! />t+-po9t4 ,?is is call$ ! 8positive phase40 ,! am\nt ( ! opson9s 9 ! blood rema9s /ation>y = a v>iable l5g? ( "t1 & !n dim9i%es4 ,z soon z _! dim9ution is not$1 a second injection ( ! vacc9e is giv51 :i* is foll[$ by a negative phase1 b less pron\nc$ ?an be=e4 ,soon ! positive phase comes on1 rea*+ a high] level ?an previ\sly4 ,?us ! injections are repeat$ f "t to "t accord+ to ! opsonic index ( ! pati5t's blood1 & ! positive phase gradually atta9s a high] & high] level1 until x may be z high z or consid]ably high] ?an t ( a normal p]son4 ,9 o!r words1 if ! vacc9ations are prop]ly giv51 8nev] dur+ a negative phase10 & z a result ! pati5t's tissues are /imulat$ to an increas$ production ( ! opson9s1 phagocytosis is increas$1 ! invad+ bact]ia are dispos$ (1 & ! pati5t recov]s f 8 infection4 ,! prop] h&l+ ( pati5ts accord+ to ?is me?od requires ! greate/ att5tion to details ( te*nique = obta9+ ! opsonic index1 prep>+ ! vacc9e1 & ! adm9i/ration ( ! prop] dose at ! prop] "t4 ,x is too e>ly to "k ! ultimate results t may be expect$ f ! use ( ! vacc9es1 b f p]sonal obs]vation1 conv]sation ) o!r work]s1 & num]\s reports1 mo/ ( :i* are incomplete1 x seems reasonable to believe t = localiz$ bact]ial infections mu* may be accompli%$4 ,especially does ?is seem probable = acne1 furunculosis1 sycosis1 abscesses1 & lupus1 ad5itis1 & o!r simil> tub]cul> infections4 ,9 incipi5t pulmon>y tub]culosis enc\rag+ results h be5 obta9$ :]e m9ute doses ( new tub]cul91 #a_/ajjj ( a milligramme m or less1 h be5 giv51 :i* seem+ly %[ t ,ko*'s orig9al obs]vations 7 well gr\nd$ 9 fact4 ,some?+ has be5 accompli%$ 9 ^? diseases 9 :i* ! bact]ial infection is 9 ! blood /ream4 ,aft] a c>eful consid]ation ( ! lit]ature ( ! entire subject ,i believe we %\ld recognize ! new !rapy z an exp]im5tal proc$ure ( mu* promise1 b until m ext5d$ obs]vations h be5 made ! use ( ! vacc9es %\ld n be look$ ^u z a settl$ me?od ( treatm5t4 ,,ph>maceutical ,,meet+4 ,! /at$ ,ph>maceutical ,meet+ ( ! ,philadelphia ,college ( ,ph>macy 0 held on ,tuesday aft]noon1 ,febru>y #ai?1 ) ,m4 ,i4 ,wilb]t1 ,ph4,m41 9 ! *air4 ,pr(4 ,*>les ,h4 ,la ,wall 0 ! fir/ speak] on ! program1 & pres5t$ a pap] on 8,! ,food & ,drugs ,act 9 its ,relation to ,public ,heal?40 7,see p4 #ajg47 ,! au?or review$ conditions lead+ up to ! passage ( ! ,unit$ ,/ates ,food & ,drugs ,act ( ,june1 #aijf1 & 9 consid]+ ! detail$ provisions ( ! law1 paid p>ticul> att5tion to ! section on misbr&+4 ,mr4 ,?omas ,h4 ,potts call$ att5tion to a =m ( deception 9 :i* x is made to appe> t ! s]ial numb] plac$ by manufactur]s on packages is a ,gov]nm5t gu>antee numb]4 ,pr(4 ,h5ry ,kraem] said t !re is a ne$ = m work]s along ?is l9e4 ,he ref]r$ to ! "w :i* has be5 done by ,dr4 ,wiley1 & said t he des]v$ great cr$it n only = 8 ef=ts 9 secur+ ! adoption ( ! ,pure ,food & ,drugs ,act1 b also = /&+ out s _m ye>s aga9/ ! money$ int]e/s repres5t$ by unscrupul\s manufactur]s4 ,! subject ( drug legislation 0 br\ght up & ,mr4 ,wilb]t said t ph>maci/s 7 mak+ a mi/ake 9 n tak+ an active "p 9 x4 ,he /at$ t 9 ,v]mont ! druggi/s _h hesitat$ 9 ! matt]1 & t ! groc]s ( t ,/ate _h succe$$ 9 hav+ a law enact$ :i* may prove inimical to ! int]e/s ( ph>maci/s4 ,he !n call$ att5tion to ! bill introduc$ 9 ! ,p5nsylvania legislature :i* is practically t ( ! ,:olesale ,groc]s' ,association1 & does n exempt physicians' prescriptions & ! prep>ations ( ! ,unit$ ,/ates ,ph>macopia & ,national ,=mul>y 9 ^? portions ( ! bill :i* relate to labell+4 ,mr4 ,wilb]t fur!r /at$ t ?is bill is be+ introduc$ 9 ! legislatures 9 a numb] ( ,/ates1 :ile ! bill =mulat$ by ! ,ladies' ,home ,j\rnal has n[ be5 introduc$ by tw5ty ,/ate legislatures4 ,x 0 also m5tion$ t a bill draft$ by ! ,national ,:olesale ,druggi/s' ,association is be+ introduc$ 9 "s ,/ates1 & t /ill ano!r draft is t ( ! ,proprietors' ,association4 ,mr4 ,potts spoke ( ! meet+ 9 ,*icago ( ! repres5tatives ( ! ,national ,association ( ,retail ,druggi/s1 ! ,national ,:olesale ,druggi/s' ,association & ! ,proprietors' ,association1 & said t an attempt 0 made to h a law draft$ :i* w\ld require bo? physicians & retail druggi/s to use labels giv+ details z to ! composition ( m$ic9es prescrib$ & disp5s$4 ,he !n rem>k$ t retail druggi/s are n oppos$ to legislation :i* is fair1 b t !y are n 9 favor ( ha/y legislation1 :i*1 z propos$ 9 "s in/ances1 w\ld drive retail druggi/s out ( bus9ess4 ,a pap] on 8,sunday ,clos+3 ,a ,means ( ,elevat+ ,ph>macy10 by ,cl>5ce ,h4 ,campbell1 a local druggi/1 0 read 9 ! abs5ce ( ! au?or by ,george ,b4 ,weidemann1 ,p4,d4 ,! pap] conta9$ ! /atem5t t at ! rec5t conv5tions ( ! ,national ,association ( ,retail ,druggi/s held 9 ,/4 ,l\is & ,atlanta1 resolutions 7 unanim\sly adopt$ favor+ ,sunday clos+1 & t helpful sugge/ions _h be5 made z to ! ways & means ( br++ ab\t ?is end4 ,! writ] 0 ( ! op9ion t ! long h\rs )\t proportionate comp5sation has an influ5ce 9 keep+ "y m5 f tak+ up ph>macy 9 ! fir/ place1 or ( pursu+ x aft] qualify+ = ! "w4 ,mr4 ,campbell also consid]$ "s ( ! argum5ts t h already be5 advanc$ 9 "s ( ! previ\s issues ( ?is ,,j\rnal z to ! necessity ( reasonable re/ & recreation 9 broad5+ ! horizon ( ! ph>maci/4 ,mr4 ,?omas ,h4 ,potts also pres5t$ a communication on ! subject ( ,sunday clos+ & %ort] h\rs4 ,aft] consid]+ ! ne$ ( a m lib]al _s on ! "p ( ph>maci/s & ! necessity = an improvem5t 9 ! numb] ( h\rs t ! ph>maci/ is on duty1 ,mr4 ,potts said t he fully admitt$ t ! public mu/ be tak5 into consid]ation1 b ma9ta9$ t !y c be educat$1 & v readily1 to acquiesce 9 ?is movem5t if conc]t$ action be tak5 by druggi/s4 ,mr4 ,potts fur!r rem>k$ t 9 8 op9ion !re is only "o possible plan to adopt & t is to agitate ?is "q on e favorable opportunity4 ,he said t s9ce ! agitation begun la/ fall by ! ,philadelphia ,college ( ,ph>macy1 a great _m retail]s h clos$ _! /ores on ,sunday aft]noons1 & 9 conv]sation ) "s ( !m he 0 in=m$ t !y l ! plan s well t !y c\ld n be induc$ to return to ! old conditions4 ,r4 ,w4 ,cu?b]t1 *airman ( ! committee appo9t$ by ! college to help =w>d ! %ort]-h\r movem5t1 report$ t he 0 enc\rag$ by ! results t _h already be5 atta9$4 ,,flor5ce ,,yaple1 ,secret>y pro tem4 ,,proct] ,,monum5t ,,fund4 ,,g5]\s ,,subscription4 ,j z we are go+ to press ,pr(essor ,rem+ton in=ms u t ,mr4 ,john ,wye?1 a graduate ( ! ,philadelphia ,college ( ,ph>macy1 ( ! class ( #ahed1 has1 = himself1 8 firm & 8 bro!r1 subscrib$ ! sum ( #b1jjj to ! ,proct] ,monum5t ,fund4 ,mr4 ,wye? has a w>m appreciation ( ! s]vices ( ,pr(essor ,william ,proct]1 n only to ! cause ( education1 b to ev]y?+ :i* t5d$ to ! advancem5t ( ph>macy1 p>ticul>ly 8 rese>*es on p]colation & fluidextracts4 ,x is confid5tly hop$ t ,mr4 ,wye?'s example w be foll[$ by o!rs :o h equally pr(it$ by ! labors ( ! ,fa!r ( ,am]ican ,ph>macy4 ,,! ,,new ,,food ,,& ,,drugs ,,laboratory4 ,! ,philadelphia ,college ( ,ph>macy is ab\t to erect a new laboratory1 design$ to give in/ruction 9 analytical *emi/ry1 te*nical microscopy1 & o!r bran*es ( sci5ce1 especially adapt$ = /ud5ts :o desire to fit !mselves = *emi/s "u ! ,food & ,drugs ,act4 ,! ,college pur*as$ a prop]ty a numb] ( ye>s ago1 ^u :i* a s*ool-h\se _h be5 erect$ 9 #ahbe = ! ,aimwell ,s*ool ,association4 ,?is hi/oric build+ w be entirely demoli%$ & a new laboratory erect$ cov]+ ! :ole lot1 #dj x #fj feet4 ,plans are be+ prep>$ & x is fully expect$ t x w be ready = occupancy 9 ! e>ly fall4 ,a ro/] is be+ drawn up = ! c\rses = ! /ud5ts 9 ! ,food & ,drug ,laboratory1 :i* w be available %ortly4 ,! ,college has _h 9 contemplation = a numb] ( ye>s a plan = ext5d+ ! in/ruction 9 ?is dep>tm5t1 & ! passage ( ! ,food & ,drugs ,act has caus$ su* a dem& = *emi/s1 t imm$iate /eps h be5 tak5 to put ! plans 9 execution4 ----- ,footnote #a3 ,read be=e ! ,philadelphia ,bran* ( ! ,am]ican ,ph>maceutical ,association1 ,febru>y #e1 #aijg4 ,footnote #b3 ,repr9t$ f ,!rapeutic ,gazette1 ,janu>y #ae1 #aijg4 ---------------------------------------- -------------------------------- ,,transcrib]',s ,,notes #a4 ,sil5tly correct$ typographical errors & v>iations 9 spell+4 #b4 ,reta9$ ana*roni/ic1 non-/&>d1 & unc]ta9 spell+s z pr9t$4 #c4 ,enclos$ italics font 9 und]scores4