,transcrib]'s notes3 ,9 ?is transcription1 pair$ und]scores d5ote italicis$ text & a indicates a sup]script$ "*4 ,a d[nw>d arr[ prec$+ curly brackets indicates t ! bracket$ "*7s7 are subscript$1 e4g4 ,h4 ,! text conta9s "s uncommon *>act]s t w n necess>ily display correctly ) all view+ devices4 ,if "s ( ! *>act]s look abnormal1 fir/ ensure t ! device's "* encod+ is set to ,unicode 7,,utf-#h74 ,! default font might also ne$ to be *ang$ to a ,unicode font su* z ,arial ,unicode ,,ms1 ,deja,vu1 ,segoe ,,ui ,symbol or ,free,serif4 ,symbols repres5t+ male & female h be5 replac$ by ,m & ,f 9 ! h&held v]sion4 ,subscript$ & sup]script$ *>act]s d n always display correctly on h&held devices4 ,! book conta9$ innum]able typographical errors affect+ spell+1 punctuation & =matt+4 ,mo/ spell+ errors h be5 correct$ sil5tly1 b spell+ v>iants t ma9ly reflect contempor>y spell+s 9 ! orig9al quot$ s\rces1 h be5 left un*ang$4 ,a li/ ( ! corrections & v>iations c be se5 at ! end ( ! transcription4 ,punctuation anomalies 7errors1 omissions1 duplications7 h mo/ly be5 correct$ sil5tly1 b miss+ apo/rophes h n be5 correct$ because ( unc]ta9ty ab\t int5d$ mean+4 ,a few miss+ quotation m>ks h be5 ins]t$ )9 curly brackets & miss+ words ins]t$ by ! transcrib]1 e4g4 sic & h also be5 enclos$ )9 curly brackets to diff]5tiate !m f ! num]\s words & phrases ins]t$ by ! au?ors4 ,r$undant duplicat$ words h be5 delet$4 ,a/ute read]s w probably note p]si/+ inconsi/5cies involv+ italics1 fonts1 hyph5ation1 ellipses1 acc5ts1 & ligatures 7ae_/1 oe_/7 t h be5 left un*ang$ because !y h no impact on int]pretation ( ! text4 ,! ,table ( ,cont5ts does n correspond accurately ) head+s us$ 9 ! text4 ,footnotes are g5]ally locat$ bel[ ! relevant p>agraphs2 h[ev]1 footnotes t are cross-ref]5c$ multiple times h n be5 duplicat$4 ,an error 9 footnote numb]+ 0 correct$ sil5tly1 & a miss+ footnote #abj 0 ins]t$ aft] be+ id5tifi$ 9 ! orig9al s\rce4 ,ov]-siz$ tables h be5 compress$ & :]e appropriate a key has be5 ins]t$ to assi/ ! read]4 ,,! ,,propag&a ,,= ,,re=m ,,9 ,propriet>y ,m$ic9es ,,volume #b ,"p ,i ,reports ( ! ,c\ncil ,"p ,,ii ,contributions f ! ,laboratory ,"p ,,iii ,j\rnal ,contributions3 ,propriet>y ,products ,"p ,,iv ,j\rnal ,contributions3 ,miscellany ,,press ,,( ,,am]ican ,,m$ical ,,association1 ,,five ,,hundr$ ,,& ,,?irty-,,five ,,nor? ,,de>born ,,/reet1--,,*icago #aibb ,,copyright1 #aibb ,,by ,,! ,,am]ican ,,m$ical ,,association ,,preface ,,to ,,volume #b ,!re 7 n9e editions ( ! fir/ volume ( ,! ,propag&a = ,re=m 9 ,propriet>y ,m$ic9es4 ,! n9? edition conta9$ ! mo/ important reports ( ! ,c\ncil on ,ph>macy & ,*emi/ry & ( ! ,*emical ,laboratory4 ,x conta9$ also ^? articles f ,! ,j\rnal ( ! ,am]ican ,m$ical ,association 7up to1 & includ+1 #aiaf7 :i* dealt ) ! problems ( propriet>y%ip 9 m$ic9e & ! fur!rance ( rational drug !rapy4 ,! pres5t volume conta9s simil> mat]ial cov]+ ! p]iod f ,janu>y1 #aiag1 to ,april1 #aibb1 inclusive4 ,l ,volume #a1 ?is volume is divid$ into f\r p>ts3 ,"p ,i4 ,,! ,,c\ncil ,,on ,,ph>macy ,,& ,,*emi/ry3 ,?is section pres5ts ! pr9ciples & rules :i* gov]n ! ,c\ncil 9 ! exam9ation ( m$icam5ts1 toge!r ) articles & reports be>+ on ! "w ( ! ,c\ncil1 & ! mo/ important reports ( ! ,c\ncil f #aiag to ,april1 #aibb1 inclusive4 ,"p ,,ii4 ,,! ,a4 ,m4 ,a4 ,,*emical ,,laboratory3 ,?is section1 besides pres5t+ ! aims & objects ( ! ,association's ,*emical ,laboratory1 also outl9es "s ( ! ,laboratory's "w :i* is ( p>ticul> int]e/ to physicians4 ,"p ,,iii4 ,,contributions ,,f ,,! ,,j\rnal3 ,propriet>y ,products3 ,?is "p conta9s articles on propriet>y m$ic9al prep>ations & ! me?ods by :i* !y are exploit$1 :i* h appe>$ 9 ,! ,j\rnal ,a4 ,m4 ,a4 ,"p ,,iv4 ,,contributions ,,f ,,! ,,j\rnal3 ,,miscellany3 ,9 ?is section are articles deal+ ) matt]s ( int]e/ to ! m$ical pr(ession b n com+ /rictly "u ! classification ( propriet>y m$ic9al prep>ations4 ,a comp>ison ( ! mat]ial t has appe>$ 9 ,volume #a ( ,! ,propag&a = ,re=m ) t :i* appe>s 9 ?is volume w reveal ! *ang+ conditions 9 ! propriet>y m$ic9e field4 ,_m ( ! reports 9 ! fir/ volume br\ght out ! fact t m$ic9al prep>ations 7 at t "t foi/$ on ! pr(ession ) false claims ( composition2 reports ( ?is "* are less conspicu\s 9 ! pres5t volume4 ,_m ( ! reports 9 ,volume #b deal ) unw>rant$ !rapeutic claims1 especially ^? advanc$ = animal organ prep>ations1 s]ums1 vacc9es1 prep>ations = intrav5\s m$ication1 etc4 ,! pres5t volume w also be f\nd ( int]e/ 9 its portrayal ( ! *ang$ conditions 9 ! propriet>y m$ic9e bus9ess br\ght ab\t by ! ,_w ,w>4 ,special att5tion is direct$ to ! index 9 ?is volume4 ,x is1 9 effect1 a bibliography1 includ+ ref]5ces n only to articles 9 ?is book b also 7#a7 to articles :i* appe>$ 9 ,volume #a2 7#b7 to articles on ! same g5]al subject 9 ,! ,j\rnal ( ! ,am]ican ,m$ical ,association1 & 7#c7 to ! articles appe>+ 9 ! annual reports ( ! ,c\ncil on ,ph>macy & ,*emi/ry & ( ! ,a4 ,m4 ,a4 ,*emical ,laboratory1 b n repr9t$ 9 ei!r volume ( ! ,propag&a = ,re=m 9 ,propriet>y ,m$ic9es4 ,,preface ,,to ,,volume #a3 ,,n9? ,,edition ,f "t to "t ,! ,j\rnal ( ! ,am]ican ,m$ical ,association has publi%$ ! reports ( ! ,c\ncil on ,ph>macy & ,*emi/ry & ! ,*emical ,laboratory1 z well z o!r matt] on propriet>y m$ic9es4 ,repeat$ reque/s = "s ( ! matt] h l$ to ! compilation ( 8,! ,propag&a = ,re=m 9 ,propriet>y ,m$ic9es10 :i*1 9 ! pres5t volume1 atta9s its n9? edition4 ,! sev5?1 eigh? & n9? editions h be5 compil$ on slightly diff]5t pr9ciples f _! pr$ecessors4 ,! !rapeutic re=m "w ( ,! ,j\rnal & ( ! ,association's ,*emical ,laboratory 0 at fir/ conf9$ almo/ entirely to ! criticism & analysis ( ! s-call$ e?ical propriet>ies4 ,?is 0 "r2 ! m$ical pr(ession ow$ x to ! public to combat ! no/rum evil )9 its own ranks4 ,z ! m flagrant evils ( ! 8e?ical propriet>y0 "q 7 mitigat$1 ! ,association has turn$ ! light on ! m widespread & dang]\s 8pat5t m$ic9e0 evil4 ,! articles devot$ to 8pat5t m$ic9es0 or quack]y be+ naturally ( great] int]e/ to ! g5]al public ?an to ! m$ical pr(ession1 ! numb] ( inquiries f laym5 reg>d+ v>i\s quacks & no/rums has /eadily increas$4 ,x has be5 ?\ght be/1 !re=e1 to publi% sep>ately all ( ! matt] f ,! ,j\rnal relative to quack]y & to ^? no/rums exploit$ only or *iefly to ! public1 & to include 9 ! ,propag&a = ,re=m practically none ( ! matt] t is ( direct int]e/ prim>ily to laym54 ,9 "o or two in/ances 9 :i* ! subjects 7 ( equal int]e/ to ! pr(ession & to ! public1 matt] t has already appe>$ 9 8,no/rums & ,quack]y0 is also giv5 "h2 b z a g5]al rule ! cont5ts ( ! n9? edition ( 8,! ,propag&a = ,re=m0 are ( /rictly pr(essional int]e/4 ,^? physicians :o are desir\s ( obta9+ 9 conv5i5t =m ! matt] deal+ ) 8pat5t m$ic9es0 %\ld ord] ! book 8,no/rums & ,quack]y0 or ! v>i\s pamphlets on ! same subjects t h be5 issu$ s9ce 8,no/rums & ,quack]y0 came f ! press4 ,! n9? edition ( 8,propag&a = ,re=m0 conta9s a numb] ( new articles1 greatly increas+ ! size ( ! book4 ,x also conta9s "o novel feature :i* greatly enhances its value4 ,! index includes ref]5ces n only to articles 9 ! book1 b also to matt] on propriet>ies n accept$ by ! ,c\ncil on ,ph>macy & ,*emi/ry :i* appe>$ 9 ,! ,j\rnal ( ! ,am]ican ,m$ical ,association & else:]e4 ,?is index makes ( ?is edition ( 8,propag&a = ,re=m0 a v full "w ( ref]5ce on propriet>ies :i* are undes]v+ ( recognition4 ,x %\ld be und]/ood1 h[ev]1 t n all articles index$ are condemn$2 "s are m]ely discuss$ & comp>$4 ,,resolution ,,endors+ ,,! ,,"w ,,( ,,! ,,c\ncil ,,on ,,ph>macy ,,& ,,*emi/ry ,pres5t$ at ! ,san ,francisco ,session & ,sign$ by ,all ! ,memb]s ( ! ,h\se ( ,delegates 9 ,att5dance ---------------------------------------- --------------------------- ,resolv$1 ,we1 ,memb]s ( ! ,h\se ( ,delegates ( ! ,am]ican ,m$ical ,association1 believe t e ef=t mu/ be made to d away ) ! evils :i* result f ! exploitation ( ! sick = ! sake ( ga94 ,e>ne/ly believ+ t ! cont9u$ tol]ation ( secret1 semisecret1 unsci5tific or untru?fully adv]tis$ propriet>y m$ic9es is an evil t is inimical to m$ical progress & to ! be/ int]e/ ( ! public1 we decl>e ourselves 9 sympa?y )1 endorse & by our be/ ef=ts w fur!r1 ! "w :i* has be51 & is be+1 done by ! ,c\ncil on ,ph>macy & ,*emi/ry ( ! ,am]ican ,m$ical ,association 9 ! attempt to elim9ate ?is evil4 ---------------------------------------- --------------------------- ,,table ,,( ,,cont5ts ,,"p ,i3 ,,c\ncil ,,reports ,,page ,=eword #a ,(ficial ,rules ( ! ,c\ncil on ,ph>macy & ,*emi/ry #c ,! ,c\ncil on ,ph>macy & ,*emi/ry1 ,pres5t & ,future #ab 8,accept$ by ! ,c\ncil on ,ph>macy & ,*emi/ry0 #ai ,help+ ! ,c\ncil #bj ,delays 9 ,pass+ on ,products #bj ,coop]ation ( ! ,ph>maceutical ,h\ses #ba ,budwell's ,emulsion ( ,cod-,liv] ,oil1 ,nos4 #a & #b #bb ,rheumalg9e #bc ,gray's ,glyc]9e ,tonic #bd ,tongal9e & ,ponca ,comp\nd #bf ,alfatone #bh ,uricsol #cj ,jubol #ca ,urodonal #cb ,=mam9t #cc ,hydragog9 #da ,filud9e #da ,lactopept9e & ,elixir ,lactopept9e #dc ,iodum-,mill] & ,iod-,izd-,oil 7,mill]'s7 #di ,elixir ,iodo-,bromide ( ,calcium ,comp4 8,)\t ,m]cury0 & 8,) ,m]cury0 #eb ,leci?9 ,prep>ations ,omitt$ f ,n4 ,n4 ,r4 #ec ,propriet>y ,names = ,liquid ,petrolatum #ee ,s5g #ee ,fros/'s ,blaud ,capsules #ef ,tyree's ,elixir ( ,bu*u & ,hyoscyamus ,comp\nd #eg ,hydrole9e #eh ,curative ,vacc9e1 ,brus*ett9i #eh ,/e>n's ,w9e #ei ,protonucle9 & ,protonucle9 ,beta #ei ,hydrops9 #fa ,digitalysatum #fc ,s-,call$ ,secret9 ,prep>ations #fd ,has ,secret9 a ,!rapeutic ,value8 #fe ,radio-,rem #gi ,olio-,phlogosis #gi ,! ,hypophosphite ,fallacy #hj ,pulvoids ,calcylates #he ,sulfuryl ,monal #hf ,m>k ,:ite ,goit] ,s]um & ,m>k ,:ite ,iod9iz$ ,oil #hg ,kora-,konia #ib ,! ,!rapeutic ,value ( ! ,glyc]ophosphates #ic ,hydras #if ,brom9-,iod9 ,comp\nd #ig ,ammonium ,hypophosphite ,omitt$ f ,n4 ,n4 ,r4 #ih ,alphozone ,omitt$ f ,n4 ,n4 ,r4 #ii ,calcium ,glyc]ophosphate & ,sodium ,glyc]ophosphate ,omitt$ f ,n4 ,n4 ,r4 #ii ,g>dn]'s ,syrup ( ,ammonium ,hypophosphite ,omitt$ f ,n4 ,n4 ,r4 #ajj ,glut5 ,products ,made by ! ,kellogg ,food ,company #ajj ,iodo-,mangan ,omitt$ f ,n4 ,n4 ,r4 #ajf ,liquid ,albol5e #ajf ,naphey's ,m$icat$ ,ut]9e ,waf]s #ajg ,nujol #ajh ,pulvoids ,natrium ,comp\nd #ajh ,sal(orm #aaj ,secretog5 #aaj ,iron ,citrate ,gre5 #aae ,aspir9 #aaf ,pil4 ,casc>a ,comp\nd-,rob9s #aag ,ca/a-,flora #aah ,firwe9 #aai ,firolyptol ,pla9 & ,firolyptol ) ,kreosote #abj ,b9iodol #aba ,comp>ative ,symptoms ,result+ f ! ,use ( ,sev]al ,oily ,susp5sions ( ,r$ ,m]curic ,iodid 7,m]cury ,b9iodid7 #abc ,corpora ,lutea 7,soluble ,extract71 ,p>ke1 ,davis ,co4 #abh ,:eel]'s ,tissue ,phosphates #abi ,! ,claim$ ,galactagogue ,effects ( ,nutrolactis & ,goat's ,rue ,n ,sub/antiat$ #aca ,! ,alleg$ ,galactagogue ,action ( ,galega & ,nutrolactis #aca ,! ,russell ,emulsion & ! ,russell ,prep>$ ,gre5 ,bone #acd ,brom-,i-,phos #acf ,creosote-,delson & ,cre(os #acg ,tr9]'s ,am]ican ,elixir ( ,bitt] ,w9e #aci ,trime?ol #adj ,f]riv9e1 ,intram9e & ,collosol ,iod9e #add ,eskay's ,neuro ,phosphates #adf ,k-,y ,lubricat+ ,jelly #adg ,ziratol #adh ,gonosan #aej ,alcre/a ,ipecac #aec ,iodeol & ,iodagol #aed ,capsules ,bismu? ,resorc9ol ,comp\nd ,n ,admitt$ to ,n4 ,n4 ,r4 #aeg ,dixon's ,tub]cle ,bacilli ,extract & ,dixon's ,susp5sion ( ,dead ,tub]cle ,bacilli #aeh ,=mosol #aeh ,iodol5e1 a ,solution ( ,iod9 9 ,liquid ,petrolatum1 ,inadmissible to ,n4 ,n4 ,r4 #aei ,kalak ,wat] #afj ,m9son's ,soluble ,iod9 8,kelpid9e0 ,n ,admitt$ to ,n4 ,n4 ,r4 #afa ,nutone #afb ,tri-,ars5ole1 ,l4 ,o4 ,comp\nd ,no4 #a & ,l4 ,o4 ,comp\nd ,no4 #b #afc ,unctol #aff ,v-,e-,m 7,s*oonmak] ,laboratories1 ,inc47 #aff ,hemo-,!rap9 #afh ,v5osal #afi ,secret9-,bev]idge & ! ,u4 ,s4 ,pat5t ,law #agj ,! ,"q ( ! ,/ability ( ,secret9 #aga ,ne$ = ,pat5t ,law ,revision #agg ,surgod9e #ahj ,m$eol ,suppositories #aha ,guaiod9e #ahc ,sev]al 8,mix$0 ,vacc9es ,n ,admitt$ to ,n4 ,n4 ,r4 #ahd ,oph?almol-,l9demann #ahi ,silvol ,ineligible = ,n4,n4,r #ahi ,ka?>mon #aia ,iod9iz$ ,emulsion 7,scott7 & ,creosotonic 7,scott7 #aib ,campetrod9 & ,campetrod9 ,no4 #b #aic ,c>m9zym #aid ,phillips' ,phospho-,muriate ( ,qu99e ,comp #aig ,b4 ,iod9e & ,b4 ,oleum ,iod9e #aih ,b4 ,iod9e ,products #aii ,anti?yroid ,prep>ations 7,anti?yroid9-,moebius & ,?yreoidect97 ,omitt$ f ,n4 ,n4 ,r4 #bjb ,cephael9 & ,syrup ,cephael9-,lilly ,omitt$ f ,n4 ,n4 ,r4 & ,syrup ,emetic-,lilly ,n ,accept$ #bjc ,colal9 ,omitt$ f ,n4 ,n4 ,r4 #bjc ,=al #bjd ,granul> ,eff]vesc5t ,bromide & ,acetanilid ,comp\nd-,mul=d #bjf ,holad9 & ,bile ,salt ,mixtures #bjg ,liquor ,santaiva1 ,s4 ,d41 ,omitt$ f ,n4 ,n4 ,r4 #baa ,maltzyme1 ,maltzyme ) ,casc>a ,sagrada1 ,maltzyme ) ,cod ,liv] ,oil1 ,maltzyme ,f]rat$ & ,maltzyme ) ,y]ba ,santa ,omitt$ f ,n4 ,n4 ,r4 #baa ,me?a=m ,omitt$ f ,n4 ,n4 ,r4 #bab ,p9eal ,gl&1 ,r$ ,bone-,m>r[ & ,?ymus ,gl& & ,_! ,prep>ations ,omitt$ f ,n4 ,n4 ,r4 #bac ,pip]az9e & ,lycetol ,omitt$ f ,n4 ,n4 ,r4 #bad ,/anol9d ,liquid ,p>aff9 ,omitt$ f ,n4 ,n4 ,r4 #bad ,we/]field's ,digitalis ,tablets #bae ,x](orm-,heyd5 & ,bismu? ,tribromph5ate-,m]ck ,omitt$ f ,n4 ,n4 ,r4 #baf ,cream ( ,mu/>d ,refus$ ,recognition #bah 8,plurigl&ul>0 ,mixtures #bah ,c]el5e ,n ,admitt$ to ,n4 ,n4 ,r4 #bai ,collosol ,coca9e ,n ,admitt$ to ,n4 ,n4 ,r4 #bba ,cuprase ,n ,admitt$ to ,n4 ,n4 ,r4 #bbb ,collosol ,prep>ations #bbc ,pulvoids ,calcylates ,comp\nd #bbf ,proteog5s ( ! ,wm4 ,s4 ,m]rell ,company #bbg 8,ars5ov5 ,s4 ,s40 & 8,ars5o-,me?-,hyd0 #bca ,hormotone & ,hormotone ,)\t ,po/-,pituit>y #bcd ,=maldehyde ,loz5ges #bce ,lavoris #bcg ,m$9al #bci ,omission ( ,cot>n9 ,salts 7,/yptic9 & ,/yptol7 f ,n4 ,n4 ,r4 #bdj ,micajah's ,waf]s & ,micajah's ,suppositories #bda ,alkali?ia #bdb ,arhov9 ,omitt$ f ,n4 ,n4 ,r4 #bdc ,*loron1 ,*lorax & ,numb] 8#c0 #bdd ,el>son ,omitt$ f ,n4 ,n4 ,r4 #bdh ,iodiphos #bdi ,m]v5ol & ,arm]v5ol ,n ,admitt$ to ,n4 ,n4 ,r4 #bdi ,normal ,ph5ol ,s]um 7,cano7 & ,me?yl-,ph5ol ,s]um 7,cano7 ,n ,accept$ = ,n4 ,n4 ,r4 #bea ,soam9 ,omitt$ f ,n4 ,n4 ,r4 #bec ,"s ,mix$ ,vacc9es ,n ,admitt$ to ,n4 ,n4 ,r4 #bed ,somn(orm #bee ,tablets ,=mo?alates #bef ,triple ,ars5ates ) ,nucle9 #bef 8,anti-,pneumococcic ,oil0 & ! ,use ( ,camphor 9 ,pneumonia #beg ,dial 8,ciba0 #bei ,apo!s9e #bfj ,eumict9e #bfb ,platt's ,*lorides #bfc ,anti-,tub]cul\s ,lymph ,comp\nd 7,swe5y7 & ,anti-,syphilitic ,comp\nd 7,swe5y7 #bff ,syrup ,lept9ol 7,=m]ly ,syrup ,balsamea7 #bfh ,=mitol ,tablets1 ,,ii #bga ,sukro-,s]um & ,aphlegmatol #bgc ,supsalvs ,n ,admitt$ to ,n4 ,n4 ,r4 #bgd ,hypod]mic ,solution ,no4 #ac1 ,iron1 ,ars5ic & ,phosphorus ,comp\nd ,n ,accept$ = ,n4 ,n4 ,r4 #bge ,p>a!s9 ,n ,admitt$ to ,n4 ,n4 ,r4 #bgf ,*lorlyptus #bgg ,aquazone 7,oxyg5 ,wat]7 #bij ,coagul5-,ciba ,omitt$ f ,n4 ,n4 ,r4 #bij ,f]ric ,cacodylate ,omitt$ f ,new & ,non-,(ficial ,rem$ies #bib ,libradol #bic ,helmitol ,omitt$ f ,n4 ,n4 ,r4 #bie ,spirocide ,n ,admitt$ to ,n4 ,n4 ,r4 #bif ,digifol9-,ciba ,n ,admitt$ to ,n4 ,n4 ,r4 #bih ,"s ( ,loess]'s ,intrav5\s ,solutions #bii 8,national ,iod9e ,solution0 ,n ,admitt$ to ,n4 ,n4 ,r4 #cjj ,mon-,arsone ,n ,admitt$ to ,n4 ,n4 ,r4 #cjb ,oxyl-,iodide ,n ,admitt$ to ,n4 ,n4 ,r4 #cjd ,quassia ,comp\nd ,tablets #cjf ,toxicide #cjg ,pil4 ,mix$ ,treatm5t 7,*i*e/]7 #caj ,atophan ,omitt$ f ,n4 ,n4 ,r4 #cac ,urotrop9 ,omitt$ f ,n4 ,n4 ,r4 #caf ,/yptysate ,n ,admitt$ to ,n4 ,n4 ,r4 #cah ,lipoidal ,sub/ances 7,horovitz7 ,n ,admitt$ to ,n4 ,n4 ,r4 #cbj ,yea/ ,prep>ations & ,vitam9 ,b ,conc5trates #cba ,,"p ,,ii3 ,,contributions ,,f ,,! ,a4 ,m4 ,a4 ,,*emical ,,laboratory ,! ,*emical ,laboratory ( ! ,am]ican ,m$ical ,association #cbb ,! ,"w ( ! ,am]ican ,m$ical ,association ,*emical ,laboratory #cbb ,lead 9 8,akoz0 #cbh ,sodium ,acetate 9 ,w>m+ ,bottles #cbi ,anti-,syphilitic ,comp\nd 7,swe5y7 #ccj 8,ambr9e0 & ,p>aff9 ,films #ccj ,! ,/ability ( ,iod9e ,o9tm5ts #ccg ,iodol5e & ! ,solubility ( ,iod9 9 ,liquid ,petrolatum #cdd ,am]ican-,made ,syn!tic ,drugs--,i #cdd ,/&>dization ( ,comm]cial ,bismu? ,tribromph5ate #cdh ,/&>dization ( ,proca9 & ,exam9ation ( ! ,m>ket ,supply #cee ,det]ioration ( ,sodium ,hypo*lorite ,solutions #ceh ,syphilodol #cei ,c]el5e #cfb ,dr4 ,de ,sanctis' ,rheumatic & ,g\t ,pills #cfc ,iodex & ,liquid ,iodex #cfe ,,"p ,,iii3 ,,contributions ,,f ,,! ,,j\rnal3 ,,propriet>y ,,products ,iod9 9 ,liquid ,petrolatum #cfg ,am]ican-,made ,syn!tic ,drugs--,,ii #cfi ,no/rums 9 ,retrospect #cgi ,bell-,ans 7,pa-,pay-,ans ,bell7 #chj ,anas>c9 & ,an$em9 #chc ,pepto-,mangan #chg ,cact9a ,pillets #cia ,ammonol & ,ph5alg9 #cic ,fell[s' ,syrup1 & ,o!r ,prep>ations ( ! ,hypophosphites #cie ,%otgun ,no/rums #cih ,tyree's ,antiseptic & ,asept9ol #dja ,neuros9e & ! ,orig9al ,package ,evil #djd ,anas>c9 ,adv]tis+ #djg ,antim]i/em-,s*midt #djh ,antiphlogi/9e #dji 8,auto-,hemic ,s]um0 #dji 8,autolys90 ,adv]tis+ #dac 8,basic ,canc] ,rese>*0 & 8,cosmopolitan ,canc] ,rese>* ,society0 #dad ,sel5i-,bascca #daf ,bell-,ans 7,papayans1 ,bell7 #dah ,campho-,ph5ique #dah 8,c9*oph503 ,=m]ly 8,atophan0 #dai 8,collosols03 ,an ,uncritical ,engli% ,endorsem5t #dbj ,cotton ,process ,e!r #dba ,dionol #dbb ,! ,eli ,products ( ,eli ,h4 ,dunn #dbd ,glov]'s ,canc] ,s]um #dbe ,glyco-,?ymol9e & ,poliomyelitis #dbg ,glyk]on3 ,cold ,/orage ,te/imonials #dbh ,gray's ,glyc]9e ,tonic3 8,^: ,bread ,i ,eat ,8 ,song ,i ,s+0 #dbi ,hagee's ,cordial ( ,cod ,liv] ,oil #dbi ,hypno-,bromic ,comp\nd #dcj ,intrav5\s ,comp\nd 7,l(fl]7 #dcj ,intrav5\s ,specialties #dce ,iodex #dcf ,! ,william ,f4 ,ko* ,canc] ,rem$y #dcg ,! ,lucas ,laboratories' ,products #ddj 8,phylacog5s0 #dda ,p9eoleum ,adv]tis+ ,me?ods #ddb 8,proteal ,!rapy0 & ,h5ry ,smi? ,williams #ddc ,proteog5s #dde ,pulvane #dej ,sal ,hepatica #dea ,salicon #dec ,s-,call$ ,secret9 ,prep>ations #ded ,succus ,c9]>ia ,m>itima #dee ,tek>k9 #deh ,tyree's ,antiseptic ,p[d] ,aga9 #dfb ,:eel]'s ,tissue ,phosphates #dfc ,brief] ,p>agraphs #dfe ,,"p ,,iv3 ,,contributions ,,f ,,! ,,j\rnal3 ,,miscellany ,alb]t ,abrams1 ,a4,m41 ,m4,d41 ,,ll4,d41 ,f4,r4,m4,s4 #dgb ,acetylsalicylic ,acid1 ,n ,aspir9 #dhj ,! ,alli$ ,m$ical ,associations ( ,am]ica #dhf 8,ars5icals0 #dia ,be] & ,canc] ,cures #did ,biologic ,!rapeutics & ,its ,comm]cial ,dom9ation #dif ,capell's ,uroluetic ,te/ #dig ,*emo!rapy & ,tumors #dii ,! ,direct ,sales ,company #eaj ,discov]ies & ,discov]]s #eaa 8,drug ,re=m0 #eac ,drug ,!rapy3 ,! ,fallibility ( ,textbooks #eae ,?omas ,web/] ,edg> #eae ,glyc]ophosphates #ebj ,influ5za ,vacc9e #ebj ,intrav5\s ,!rapy #ebb ,iod9 ,fumes #ebc ,italian ,physico-,*emical ,company #ebd ,:at is ,liquid ,petrolatum8 #ebf ,! ,l[5?al ,po/graduate ,c\rse #ebg ,m$ical ,society ( ! ,unit$ ,/ates #eca ,! ,national ,=mul>y--,a ,review ( ! ,f\r? ,edition #ece ,nonspecific ,prote9 ,!rapy #ecf ,will>d ,ealon ,ogd5 #ech 8,pat5ts0 #edb ,ph>maceutical ,b>nums #ede ,! ,ph>macopeia #edf ,physician's ,/ock 9 ,prescription ,products #edh ,pituit>y ,gl& ,prep>ations #edi ,proprietor%ip 9 ,m$ic9e #eej ,philip ,rahtj5 & ,8 ,discov]ies #eec ,sodium ,cacodylate 9 ,syphilis #eee ,tablets3 ,dep5dability ( ,dosage #eef ,!rapeutic ,evid5ce3 ,its ,crucial ,te/ #eeg 8,vacc9es 9 ,toxic ,conditions0 #efj ,vitam9s3 ,_! ,di/ribution #efa ,! ,william ,a4 ,web/] ,co4 & ! ,direct ,ph>maceutical ,co4 #efd ,yea/ #eff ,brief] ,p>agraphs #egj ,,! ,,propag&a ,,= ,,re=m ,,9 ,,propriet>y ,,m$ic9es ,,"p ,i ,,reports ,,( ,,! ,,c\ncil ,,on ,,ph>macy ,,& ,,*emi/ry ,,=eword ,,! ,,c\ncil ,,on ,,ph>macy ,,& ,,*emi/ry ,! ,c\ncil on ,ph>macy & ,*emi/ry 0 e/abli%$ by ! ,am]ican ,m$ical ,association prim>ily = ! purpose ( ga!r+ & dissem9at+ su* in=mation z w\ld protect ! m$ical pr(ession--& ?us ! public--9 ! prescrib+ ( propriet>y m$ic9al articles4 ,! ,c\ncil consi/s ( sixte5 memb]s1 fifte5 appo9t$ = a t]m ( five ye>s )\t pay1 & ! sixte5?1 a secret>y1 :o is also ! director ( ! ,*emical ,laboratory ( ! ,am]ican ,m$ical ,association 7see ,"p ,,ii74 ,at ! pres5t "t 7#aiba7 ! memb]%ip is3 ,c4 ,l4 ,alsb]g1 ,a4,m41 ,m4,d41 ,*ief ( ! ,bureau ( ,*emi/ry1 ,u4 ,s4 ,dep>tm5t ( ,agriculture1 ,wa%+ton1 ,d4 ,c4 ,c4 ,w4 ,edmunds1 ,m4,d41 ,pr(essor ( ,mat]ia ,m$ica & ,!rapeutics1 ,univ]sity ( ,mi*igan ,m$ical ,s*ool1 ,ann ,arbor4 ,r4 ,a4 ,hat*]1 ,ph4,g41 ,m4,d41 ,pr(essor ( ,ph>macology1 ,cornell ,univ]sity ,m$ical ,college1 ,new ,york ,city4 ,a4 ,w4 ,hewlett1 ,m4,d41 ,pr(essor ( ,m$ic9e1 ,lel& ,/an=d ,junior ,univ]sity ,s*ool ( ,m$ic9e1 ,san ,francisco4 ,john ,h[l&1 ,m4,d41 ,pr(essor ( ,p$iatrics1 ,johns ,hopk9s ,univ]sity ,m$ical ,dep>tm5t1 ,baltimore4 ,reid ,hunt1 ,m4,d41 ,pr(essor ( ,ph>macology1 ,m$ical ,s*ool1 ,h>v>d ,univ]sity1 ,bo/on4 ,w4 ,t4 ,longcope1 ,a4,b41 ,m4,d41 ,new ,york4 ,g4 ,w4 ,mc,coy1 ,m4,d41 ,director ( ! ,hygi5ic ,laboratory1 ,u4 ,s4 ,public ,heal? ,s]vice1 ,wa%+ton1 ,d4 ,c4 ,lafayette ,b4 ,m5del1 ,ph4,d41 ,sc4,d41 ,pr(essor ( ,physiological ,*emi/ry1 ,%effield ,sci5tific ,s*ool1 ,yale ,univ]sity1 ,new ,hav54 ,f4 ,g4 ,novy1 ,sc4,d41 ,m4,d41 ,pr(essor ( ,bact]iology1 ,univ]sity ( ,mi*igan ,m$ical ,s*ool1 ,ann ,arbor4 ,w4 ,w4 ,palm]1 ,b4,s41 ,m4,d41 ,b>d ,pr(essor ( ,m$ic9e1 ,columbia ,univ]sity ,college ( ,physicians & ,surgeons1 ,new ,york4 ,w4 ,a4 ,puckn]1 ,ph>4,d41 ,secret>y ( ! ,c\ncil1 ,director ( ! ,*emical ,laboratory ( ! ,am]ican ,m$ical ,association1 ,*icago4 ,l4 ,g4 ,r[ntree1 ,m4,d41 ,sc4,d41 ,pr(essor ( ,m$ic9e1 ,mayo ,f\ndation1 ,ro*e/]4 ,g4 ,h4 ,simmons1 ,m4,d41 ,,ll4,d41 ,*airman ( ! ,c\ncil1 ,editor ( ,! ,j\rnal ( ! ,am]ican ,m$ical ,association1 ,*icago4 ,torald ,sollmann1 ,m4,d41 ,pr(essor ( ,ph>macology & ,mat]ia ,m$ica1 ,we/]n ,res]ve ,univ]sity ,s*ool ( ,m$ic9e1 ,clevel&4 ,julius ,/ieglitz1 ,ph4,d41 ,sc4,d41 ,*em4,d41 ,pr(essor ( ,*emi/ry1 ,univ]sity ( ,*icago1 ,vice-,*airman ( ! ,c\ncil1 ,*icago4 ,at its fir/ meet+ 9 #aije1 ! ,c\ncil began exam9+ ! propriet>y & non(ficial m$ic9al prep>ations (f]$ to physicians ( ! ,unit$ ,/ates1 & au?oriz$ ! publication ( a book 7,new & ,non(ficial ,rem$ies7 conta9+ descriptions ( ^? prep>ations :i* 7 deem$ wor?y ( ! consid]ation ( physicians4 ,x also issu$ reports 7,reports ( ! ,c\ncil on ,ph>macy & ,*emi/ry7 to ! m$ical pr(ession on ^? prep>ations :i* 7 n eligible4 ,! ,c\ncil adopt$ a set ( rules by :i* to measure ! eligibility ( ea* prep>ation = admission to ,new & ,non(ficial ,rem$ies4 ,^! rules 7 design$ prim>ily to protect ! public--?r\gh ! m$ical pr(ession--aga9/ fraud1 undesirable secrecy & objectionable adv]tis+ 9 connection ) propriet>y m$ic9al articles4 ,! rules orig9ally adopt$ h be5 subject$ to revision f "t to "t to meet *ang+ conditions4 ,= ! in=mation ( ^? :o wi% to famili>ize !mselves ) ! "w ( ! ,c\ncil ! rules :i* are n[ 9 =ce 7#aiba7 foll[ ?is introduction4 ,a summ>y is also to be f\nd 9 ! article1 8,! ,"w ( ! ,c\ncil on ,ph>macy & ,*emi/ry1 ,pres5t & ,future10 page #ab4 ,s9ce #aijf1 ! ,c\ncil has issu$ ,new & ,non(ficial ,rem$ies annually4 ,9 ea* issue are li/$ & describ$ ! articles t /& accept$ on ,janu>y #a ( ! ye> ( publication4 ,! book describes propriet>y m$ic9al articles on ! ,am]ican m>ket t are f\nd eligible "u ! rules1 & also su* nonpropriet>y1 non(ficial articles z give promise ( !rapeutic usefulness1 li/+ ! acceptable br&s4 ,articles ( a simil> "* are gr\p$ toge!r1 & ea* gr\p is prec$$ by a g5]al discussion = ! purpose ( comp>ison4 ,s9ce #aijh1 ! ,c\ncil has also issu$ an annual volume1 8,reports ( ! ,c\ncil on ,ph>macy & ,*emi/ry10 :i* conta9s reports on propriet>y m$ic9es t 7 f\nd inadmissible to ,new & ,non(ficial ,rem$ies4 ,! reports issu$ prior to #aiaf--;& deem$ ( suffici5t int]e/ to physicians--7 repr9t$ 9 ! ,propag&a = ,re=m 9 ,propriet>y ,m$ic9es1 n9? edition 7#aiaf74 ,! m important reports issu$ f #aiaf to #aiba1 inclusive1 are 9 ?is volume4 ,:ile x is ! *ief function ( ! ,c\ncil to inve/igate & report on propriet>y m$ic9al prep>ations1 its "w has broad5$ s t ! ,c\ncil's "w may n[ be *>act]iz$ z a propag&a = ! rational use ( drugs4 ,?us1 its ,committee on ,!rapeutic ,rese>* enc\rages ! inve/igation ( que/ions conc]n+ ! actions ( drugs4 ,^! inve/igations are br\ght toge!r 9 ! 8,annual ,reports ( ! ,!rapeutic ,rese>* ,committee40 ,! ,c\ncil also has a committee on m$ical tea*+ :i* has issu$ ! publication 8,useful ,drugs10 a concise1 b ?or\gh & up-to-date1 discussion ( ! m important drugs4 ,9 addition1 ! ,c\ncil appo9t$ a committee to prep>e an 8,epitome ( ! ,u4 ,s4 ,ph>macopeia & ,national ,=mul>y10 9 :i* are pres5t$ ^? portions ( ! ,unit$ ,/ates ,ph>macopeia & ! ,national ,=mul>y t are ( int]e/ to physicians & 9 :i* is giv5 a concise /atem5t ( ! !rapeutic usefulness ( su* drugs & prep>ations4 ,,(ficial ,,rules ,,( ,,! ,,c\ncil ,,on ,,ph>macy ,,& ,,*emi/ry ,may #a1 #aiba ,introduction ,! foll[+ rules h be5 adopt$ by ! ,c\ncil prim>ily ) ! object ( protect+ ! m$ical pr(ession & ! public aga9/ fraud1 undesirable secrecy & objectionable adv]tis+ 9 connection ) propriet>y m$ic9al articles4 ,,new ,,& ,,non(ficial ,,rem$ies4--,! book ,new & ,non(ficial ,rem$ies conta9s a description ( propriet>y articles :i* h be5 accept$ z con=m+ to ! rules ( ! ,c\ncil2 & ( su* simple nonpropriet>y & non(ficial sub/ances z seem ( suffici5t importance to w>rant _! inclusion4 ,,mixtures4--,= admission to ,n4 ,n4 ,r41 propriet>y ph>maceutical mixtures mu/ comply ) ! rules2 &1 to det]m9e su* compliance1 !y w be inve/igat$ by ! ,c\ncil4 ,! ,c\ncil1 h[ev]1 endorses ! pr9ciple t prescriptions %\ld be writt5 on ! basis ( ! !rapeutic effects ( ! individual +r$i5ts4 ,= ?is reason1 x includes 9 ?is book only ^? mixtures t pres5t "s real advantage4 ,!re is also an app5dix 9 :i* are includ$ ^? propriet>y articles :i*1 s f> z kn[n to ! ,c\ncil1 comply ) ! rules1 b :i* d n possess suffici5t orig9ality to be admitt$ to ! body ( ! book4 ,rules ,gov]n+ ! ,admission ( ,propriet>y ,articles to ! ,book ,new & ,non(ficial ,rem$ies ,,def9ition ,,( ,,propriet>y ,,articles4--,! t]m 8propriet>y article10 9 ?is place1 %all mean any *emical1 drug or simil> prep>ation us$ 9 ! treatm5t ( diseases1 if su* article is protect$ aga9/ free competition1 z to "n1 product1 composition or process ( manufacture1 by secrecy1 pat5t1 copyright1 or by any o!r means4 ,rule #a4--;,,composition4--,no article w be accept$ = inclusion 9 ! book ,new & ,non(ficial ,rem$ies1 or reta9$ !re91 unless its composition be furni%$ to ! ,c\ncil = publication4 ,= simple sub/ances1 ! sci5tific "n & ! *emical =mula1 rational or /ructural1 if kn[n1 %\ld be suppli$4 ,= mixtures1 ! am\nt ( ea* active m$ic9al +r$i5t 9 a giv5 quantity ( ! article mu/ be /at$4 ,! g5]al composition ( ! vehicle1 its alcoholic p]c5tage1 & ! id5tity ( ! pres]vatives mu/ be furni%$4 ,rule #b4--;,,id5tification4--,no article w be accept$ or reta9$ unless suitable te/s = det]m9+ its composition are furni%$ to ! ,c\ncil4 ,9 ! case ( *emical comp\nds1 ^! %all consi/ ( te/s = id5tity & purity4 ,9 ! case ( mixtures1 description ( me?ods = det]m9+ ! am\nt & active /r5g? ( ! pot5t +r$i5ts %all be furni%$1 if practicable4 ,rule #c4--;,,direct ,,adv]tis+4--,no article t is adv]tis$ to ! public w be accept$ or reta9$2 b ?is rule %all n apply to3 7a7 dis9fectants1 g]micides & antiseptics1 provid$ ! adv]tis+ is limit$ to cons]vative recomm5dations = _! use z prophylactic applications to sup]ficial cuts & abrasions ( ! sk9 & to ! muc\s surfaces ( ! m\?1 ph>ynx & nose 7b n to ^? ( ! eye1 & ! ga/ro-inte/9al & g5ito-ur9>y tracts7 & provid$ !y are n adv]tis$ z curative ag5ts 7see comm5ts to ,rule #c72 & 7b7 nonm$ic9al food prep>ations1 except :5 adv]tis$ 9 an objectionable mann]4 ,rule #d4--;,,indirect ,,adv]tis+4--,no article w be accept$ or reta9$ if ! label1 package or circul> accompany+ ! package conta9s ! names ( diseases 9 ! treatm5t ( :i* ! article is said to be indicat$4 ,! !rapeutic indications & prop]ties may be /at$1 provid$ su* /atem5ts d n sugge/ self-m$ication4 ,dosage may be indicat$4 7,?is rule %all n apply to rem$ies ) :i* self-m$ication is altoge!r improbable1 to vacc9es & antitox9s or to directions = adm9i/]+ or apply+ rem$ies :5 simil> imm$iate1 h]oic treatm5t is indicat$47 ,rule #e4--;,,false ,,claims ,,z ,,to ,,orig94--,no article w be accept$ or reta9$ conc]n+ :i* ! manufactur] or 8 ag5ts make false or mislead+ /atem5ts z to s\rce1 raw mat]ial f :i* made1 or me?od ( collection or prep>ation4 ,rule #f4--,,unw>rant$ ,,!rapeutic ,,claims4--,no article w be accept$ or reta9$ conc]n+ :i* ! manufactur] or 8 ag5ts make unw>rant$1 exagg]at$ or mislead+ /atem5ts z to ! !rapeutic value4 ,rule #g4--,,poison\s ,,sub/ances4--,! pr9cipal label on an article conta9+ 8poison\s0 or 8pot5t0 sub/ances mu/ /ate pla9ly ! am\nt ( ea* ( su* +r$i5ts 9 a giv5 quantity ( ! product4 ,rule #h4--,,objectionable ,,names4--,propriet>y names = m$ic9al articles w be recogniz$ only :5 ! ,c\ncil %all deem ! use ( su* exclusive names to be 9 ! int]e/ ( public welf>e4 ,names :i* are mislead+ or :i* sugge/ diseases1 pa?ologic conditions or !rapeutic indications w n be recogniz$ 7! provision aga9/ !rapeutically sugge/ive names does n apply to s]ums1 vacc9es & antitox9s1 or to foods74 ,9 ! case ( ph>maceutical prep>ations or mixtures1 ! "n mu/ be s fram$ z to indicate ! mo/ pot5t +r$i5ts4 ,rule #i4--,,pat5t$ ,,products ,,& ,,protect$ ,,names4--,if ! article is pat5t$--ei!r process or product1 or bo?--! numb] ( su* pat5t or pat5ts mu/ be furni%$ to ! ,c\ncil4 ,fur!rmore1 if ! "n ( an article is regi/]$1 or ! label copyright$1 ! regi/ration 7tradem>k7 numb] & a copy ( ! protect$ label %\ld be furni%$ ! ,c\ncil4 ,9 case ( regi/ration 9 =eign c\ntries1 ! "n "u :i* ! article is regi/]$ %\ld be suppli$4 ,rule #aj4--,,unsci5tific ,,& ,,useless ,,articles4--,no article w be accept$ or reta9$ :i*1 because ( its unsci5tific composition1 is useless or inimical to ! be/ int]e/s ( ! public or ( ! m$ical pr(ession4 ,explanatory ,comm5ts on ! ,rules ,,introduction4--,! ,c\ncil on ,ph>macy & ,*emi/ry 0 e/abli%$ 9 ,febru>y1 #aije1 by ! ,am]ican ,m$ical ,association1 prim>ily = ! purpose ( ga!r+ & dissem9at+ su* in=mation z w protect ! m$ical pr(ession 9 ! prescrib+ ( propriet>y m$ic9al articles4 ,9 pursuance ( ?is object1 ! ,c\ncil exam9es ! articles on ! m>ket z to _! compliance ) def9ite rules design$ to prev5t fraud1 undesirable secrecy & ! abuses :i* arise f adv]tis+ directly or indirectly to ! laity4 ,su* articles z appe> to con=m to ! rules are accept$2 & _! ess5tial features are describ$ 9 ! annual publication ( ! ,c\ncil1 ,new & ,non(ficial ,rem$ies1 if !y come )9 ! scope ( ?is book4 ,^! descriptions are bas$ 9 "p on inve/igations made by1 or "u1 ! direction ( ! ,c\ncil1 b 9 "p also on evid5ce or in=mation suppli$ by ! manufactur] or 8 ag5ts4 ,su* int]e/$ /atem5ts are exam9$ critically1 & are admitt$ only if !y appe> to be 9 con=mity ) ! evid5ce4 ,x is1 h[ev]1 manife/ly impossible = ! ,c\ncil to inve/igate ! composition ( e complex ph>maceutical mixture1 or to *eck ?or\ghly e !rapeutic claim2 x c give only an unbias$ judgm5t on ! available evid5ce4 ,criticisms & corrections ( ! descriptions :i* may aid 9 ! revision ( ! matt] w be appreciat$4 ,! ,c\ncil judges an article entirely by ! facts 9 evid5ce at ! "t ( its admission4 ,previ\s noncompliance ) ! rules 7%ort ( int5tional fraud7 does n prev5t ! favorable consid]ation ( an article :i* is 9 accord ) exi/+ rules4 ,infr+em5ts ( ! rules aft] acceptance ( an article = ,new & ,non(ficial ,rem$ies1 or ! discov]y t ! ,c\ncil's in=mation 0 incorrect1 w cause ! acceptance to be reconsid]$4 ,an article is accept$ = ,new & ,non(ficial ,rem$ies1 & w cont9ue to be includ$ 9 ! book1 ) ! und]/&+ t s]i\s violations ( ! rules1 aft] acceptance1 w be foll[$ by ! omission ( ! article & publication ( ! reasons = su* omission4 ,! ,c\ncil desires physicians to und]/& t ! admission ( an article does n imply a recomm5dation4 ,acceptance simply means t no conflict ) ! rules has be5 f\nd by ! ,c\ncil4 ,,duration ,,( ,,acceptance4--,unless an agreem5t to ! contr>y is made at ! "t ( acceptance1 articles admitt$ to ,new & ,non(ficial ,rem$ies w be reta9$ = a p]iod ( ?ree ye>s1 provid$ t dur+ t p]iod !y comply ) ! rules & regulations :i* 7 9 =ce at ! "t ( _! acceptance4 ,at ! end ( ?is p]iod all articles w be c>efully reexam9$ = compliance ) exi/+ rules4 ,p>ticul> weight w be giv5 to ! "q z to :e!r rec5t evid5ce has sub/antiat$ claims z to ! !rapeutic value ( any prep>ation1 ?is evid5ce to consi/ p>tly ( rec5t /atem5ts 9 ! lit]ature & p>tly ( ! g5]al e/eem 9 :i* ! prep>ation is held by cl9ical consultants ( ! ,c\ncil4 ,! reacceptance ( articles aft] su* reexam9ation %all be = ?ree ye>s unless a %ort] p]iod is specifi$4 ,any am5dm5ts to ! rules1 by specific requirem5ts or by int]pretation1 :i* may be made aft] ! acceptance ( an article1 %all n apply to su* article until ! p]iod ( acceptance has elaps$4 ,at ! end ( ?is p]iod ! article1 if x is n eligible "u ! am5d$ rules1 w be omitt$4 ,,! ,,scope ,,( ,,new ,,& ,,non(ficial ,,rem$ies ,,& ,,app5dix4--,to aid physicians & manufactur]s 9 decid+ :at articles come )9 ! scope ( ?is book1 or1 9 o!r words1 to enable physicians to recognize :e!r an article :i* is n describ$ 9 ,new & ,non(ficial ,rem$ies has be5 omitt$ because x does n ne$ admission or because x has be5 reject$1 ! ,c\ncil furni%es ! foll[+ m detail$ def9itions3 ,,(ficial ,,articles4--,articles (ficial 9 ! ,u4 ,s4 ,p4 or ,n4 ,f4 d n require consid]ation by ! ,c\ncil if !y are m>ket$ "u ! (ficial "n & if no une/abli%$ !rapeutic claims are made = !m4 ,^! d n require consid]ation by ! ,c\ncil1 s9ce /&>ds = !m are provid$ 9 ^! books1 & en=c$ "u ! provisions ( ! f$]al ,food & ,drugs ,act1 except t !y may be m5tion$ = in=mation4 ,consid]ation by ! ,c\ncil becomes necess>y if a ,u4 ,s4 ,p4 or ,n4 ,f4 product is (f]$ = sale "u a "n o!r ?an t1 or ! synonyms1 "u :i* ! product is describ$ 9 "o ( ^! books ( /&>ds1 or if ! proprietors or _! ag5ts advance claims t ! product possesses !rapeutic prop]ties o!r ?an ^? commonly accr$it$ to x4 ,,modifications ,,( ,u4 ,s4 ,p4 ,,& ,n4 ,f4 ,,products4--,a ph>macopeial or ,national ,=mul>y product :i* is m>ket$ "u ! (ficial title or synonym1 b ) well-f\nd$ claims t its purity1 p]man5ce1 palatability or o!r physical prop]ties excel ! (ficial /&>d1 may1 if no extraord9>y !rapeutic prop]ties are ass]t$1 be consid]$ z an (ficial article & held n to be )9 ! scope ( ,new & ,non(ficial ,rem$ies4 ,:5 su* products are m>ket$ "u ! claim t !y possess !rapeutic prop]ties o!r ?an ^? commonly accr$it$ to ! ,u4 ,s4 ,p4 or ,n4 ,f4 products ( :i* !y are modifications1 !y %all be subject to ! consid]ation ( ! ,c\ncil4 ,,specifically ,,exempt$ ,,prep>ations4--,foods1 9 g5]al1 unless m>ket$ ) ! claim t !y possess !rapeutic prop]ties %all n1 at ! pres5t "t1 be consid]$ by ! ,c\ncil4 ,me*anical appliances1 at ! pres5t "t1 %all n be consid]$ by ! ,c\ncil4 ,m9]al wat]s 7natural71 at ! pres5t "t1 %all n be consid]$ by ! ,c\ncil4 ,) ^! exceptions1 products :i* 9 ! judgm5t ( ! ,c\ncil are manufactur$ & m>ket$ 9 con=mity to ! pr9ciples und]ly+ ! rules ( ! ,c\ncil may be accept$ = ,n4 ,n4 ,r4 ,products :i* are manufactur$ & m>ket$ 9 a mann] :i* does n con=m to ! pr9ciples und]ly+ ! rules ( ! ,c\ncil %all n be accept$ = ,n4 ,n4 ,r4 ,! burd5 ( pro( 9 e/abli%+ claims = !rapeutic prop]ties ( products consid]$ by ! ,c\ncil %all lie ) ! proprietor or1 :5 a =eign made product1 ) ! ag5t :o m>kets ! product 9 ! ,unit$ ,/ates4 ,to avoid confusion ) non(ficial sub/ances m>ket$ "u simil> names1 ! ,c\ncil recomm5ds t (ficial sub/ances be prescrib$ by _! (ficial titles1 foll[$ by ! abbreviation 8,u4 ,s4 ,p40 or 8,n4 ,f402 ?us3 ,t9ctura ,nucis ,vomicae1 ,u4 ,s4 ,p42 ,elixir ,g5tianae1 ,n4 ,f4 ,,sub/ances ,,describ$ ,,9 ,,new ,,& ,,non(ficial ,,rem$ies4--,9 ! body ( ! book w be describ$ simple propriet>y sub/ances & _! prep>ations2 propriet>y mixtures if !y h orig9ality or o!r important qualities :i*1 9 ! judgm5t ( ! ,c\ncil1 entitle !m to su* place1 & important1 nonpropriet>y1 un(ficial articles4 ,! ,c\ncil recomm5ds t :5 ! latt] are prescrib$1 !y be indicat$ by ! abbreviation1 8,n4 ,n4 ,r410 ?us insur+ to ! prescrib] ! quality ( ^! articles laid d[n 9 ! book4 ,,propriet>y ,,mixtures4--,a mixture w be consid]$ z propriet>y1 & !re=e requir+ consid]ation by ! ,c\ncil = admission to ! book or app5dix1 if x conta9s any propriet>y article2 if x is m>ket$ "u a "n :i* is 9 any way protect$1 or if its manufactur] claims = x any unusual !rapeutic qualities4 ,propriet>y mixtures :i* are m>ket$ 9 con=mity ) ! rules are li/$ 9 ! app5dix ( ! book "u ! names ( ! respective manufactur]s4 ,su* propriet>y mixtures are n admitt$ to ! body ( ! book1 save 9 ! exceptional cases cit$ 9 ! prec$+ p>agraph4 ,,nonpropriet>y ,,mixtures ,,( ,,(ficial ,,sub/ances4--,s9ce ! +r$i5ts ( su* mixtures d n require consid]ation by ! ,c\ncil1 & s9ce ! mixtures are n op5 to ! propriet>y abuses :i* call = ! "w ( ! ,c\ncil1 x is n necess>y t !y %\ld be inve/igat$ by ! ,c\ncil4 ,! physician mu/ judge :e!r su* mixtures %\ld be direct$ to be prep>$ by ! ph>maci/1 or :e!r he is ju/ifi$ 9 ord]+ a ready-made prep>ation4 ,if he decides to use a ready-made1 nonpropriet>y prep>ation1 he mu/ judge = himself :e!r x is m>ket$ 9 accordance ) ! rules4 ,x %\ld1 h[ev]1 be rememb]$ t ! application ( a trade "n to any sub/ance makes x propriet>y4 ,explanation ( ,rule #a3 ,composition ,secrecy ,objectionable4--,x is n only ! "r b also ! duty ( ! physician to "k ! ess5tial composition ( :at he prescribes2 ! ,c\ncil _c compromise on ?is proposition4 ,vehicles & ,pres]vatives4--,9 ! case ( mixtures1 n only ! pot5t +r$i5t1 b also ! g5]al "* ( ! vehicle1 ! pres5ce ( alcohol1 & ! id5tity ( pres]vatives1 or ( any o!r sub/ance1 :e!r add$ or pres5t z an impurity1 mu/ be /at$ if ^! c "u any circum/ances affect ! !rapeutic action ( ! article4 ,?is1 z a rule1 does n mean ! publication ( trade secrets1 su* z flavors or ! details ( ! work+ =mula4 ,trade ,secrets4--,fur!rmore1 trade secrets w n be receiv$ z confid5tial by ! ,c\ncil1 s9ce x accepts in=mation only ) ! di/9ct und]/&+ t ?is may be freely publi%$1 at its discretion4 ,inspection ( ,factories4--,! ,c\ncil does n accept invitations to inspect factories2 its conc]n is ) ! f9i%$ products4 ,on ! o!r h&1 ! ,c\ncil requires t ! in=mation be complete & accurate z to m$ic9al +r$i5ts4 ,un(ficial ,con/itu5ts4--,un(ficial con/itu5ts ( propriet>y mixtures mu/ be pres5t$ by ! manufactur] 9 ! regul> way & mu/ be act$ on by ! ,c\ncil be=e ! prep>ations conta9+ !m c be accept$4 ,fraud4--,:5 x appe>s t a manufactur] has made a delib]ately false /atem5t conc]n+ a product1 he is ask$ to furni% an explanation2 & if ?is is n satisfactory1 ! product w n be accept$1 ev5 if ! false /atem5t is subsequ5tly correct$ or omitt$4 ,te/imonials4--,! =ego+ p>agraph applies n only to /atem5ts made to ! ,c\ncil1 b also to /atem5ts furni%$ to physicians by ! manufactur] or 8 ag5ts1 ev5 :5 ^! /atem5ts are 9 ! guise ( te/imonials4 ,explanation ( ,rule #b3 ,id5tification ,9 ord] to avoid errors 9 ! case ( *emical comp\nds1 & to gu>d aga9/ adult]ations1 lack ( pot5cy or /r5g?1 & ! mi/ak+ ( "o *emical = ano!r1 x is necess>y to h at h& suitable te/s4 ,te/s1 etc4--,if ^! facts h appe>$ 9 ! lit]ature1 or 9 /&>d textbooks1 ref]5ce to !m w be suffici5t2 b ) new *emicals1 especially syn!tics1 ! manufactur] or 8 repres5tatives w be requir$ to supply su* te/s = publication1 z w assure an intellig5t op9ion ( ^! products4 ,physiologic ,/&>dization4--,9 cases 9 :i* *emical me?ods ( id5tification are unkn[n or unreliable1 physiologic /&>dization %\ld be employ$4 ,! ,c\ncil consid]s ! phrase 8physiologically /&>diz$0 or 8assay$0 z mislead+ unless ! /&>d & me?od are publi%$ 9 suffici5t detail to p]mit ( _! control by indep5d5t inve/igators4 ,x is evid5t t :5 no /&>d is publi%$1 x is impossible to "k :e!r ! quality is high or l[1 & ! consci5ti\s manufactur] :o sets = himself a high /&>d is plac$ on a level ) ! di%one/ or c>eless "o :o adopts a l[ /&>d4 ,aga91 if ! process ( /&>dization is n publi%$1 x is impossible to le>n1 )\t actual trial1 ! relative value ( "o prep>ation z comp>$ ) t ( ano!r manufactur]1 or to confirm or disprove ! /atem5ts ( ! manufactur] z to ! quality ( 8 product4 ,/&>dization ( ,dis9fectants & ,g]micides4--,no dis9fectant or g]micide ( ! ph5ol type w be accept$ = ,new & ,non(ficial ,rem$ies ^: ph5ol coeffici5t1 det]m9$ accord+ to ! me?od ( ! ,hygi5ic ,laboratory1 ,u4 ,s4 ,p4 ,h4 ,s41 is n /at$ on ! label ( ! prep>ation4 ,explanation ( ,rule #c3 ,direct ,adv]tis+ ,lay ,adv]tis+4--,! impossibility ( controll+ ! irresponsible claims :i* are usually made 9 adv]tisem5ts to ! public1 ! well-kn[n dang]s ( sugge/+ by descriptions ( symptoms to ! m9ds ( ! p t !y are suff]+ f ! _m diseases describ$1 ! dang]s ( ! unconsci\s & innoc5t =mation ( a drug habit1 & ! evils ( h>mful self-m$ication1 includ+ ! dang]s ( ! spread ( _m infecti\s & contagi\s diseases :5 hidd5 f ! physician1 & simil> well-kn[n consid]ations1 are ! reasons = disc\rag+1 9 ! int]e/1 & = ! safety1 ( ! public1 ?is repreh5sible =m ( exploitation4 ,adv]tis+ 9 m$ical j\rnals1 etc41 di/ribut$ solely to physicians1 does n come )9 ! scope ( ?is rule4 ,exceptions4--,9 ! case ( subjects on :i* ! public %\ld be in/ruct$1 z ! use ( dis9fectants1 g]micides1 antiseptics & foods1 adv]tisem5ts to ! public1 if n 9 objectionable =ms1 are consid]$ admissible4 ,9 no case %all su* adv]tisem5ts include recomm5dations = use z curative ag5ts1 nor %all ! names ( any diseases be m5tion$ 9 exploitation4 ,if ! prep>ation is suffici5tly toxic to require caution 9 its use to prev5t poison+1 ?is fact %all be /at$ on ! label4 ,on acc\nt ( ! deplorable results :i* w\ld foll[ any abuse ( ?is privilege1 ! consci5ti\s coop]ation ( manufactur]s & _! ag5ts 9 adh]+ /rictly to ! limitations laid d[n is ask$2 & = ! same reason ! acceptance ( an article :i* is s adv]tis$ z to infr+e on ^! limitations 9 any ess5tial way 7z by nam+ diseases or by mak+ false & exagg]at$ claims7 %all be summ>ily resc9d$1 & ! reasons = su* action may be publi%$ )\t notice to manufactur] or ag5t4 ,a dis9fectant1 g]micide or antiseptic w be accept$ = description 9 ,new & ,non(ficial ,rem$ies1 & an article ( ?is class :i* has already be5 accept$ w cont9ue to be includ$ 9 ,new & ,non(ficial ,rem$ies only on ! explicit und]/&+ by ! manufactur] & ag5t t su* infr+em5ts ( ! rule w be foll[$ by deletion ( ! article & by publication ( ! facts z describ$4 ,foods4--,we may divide ! foods into ?ree gr\ps4 ,! fir/ gr\p conta9s ! ord9>y foods1 includ+ ! well-kn[n breakfa/ foods4 ,^! d n come "u ! sup]vision ( ! ,c\ncil 9 any way4 ,! second gr\p includes a l>ge & important class ( manufactur$ products1 su* z invalid & infant foods1 :i* 9 a s5se /& betwe5 ! fir/ & ?ird gr\ps4 ,! public has ! same int]e/ 9 ^! foods t ! physician has1 & usually is suppli$ ) full in=mation conc]n+ !m4 ,:ile ! prim>y recomm5dation ( ^! articles %\ld naturally come f ! physician1 x _c be expect$ t _! cont9u$ use %\ld dep5d on repeat$ prescriptions4 ,in=mation conc]n+ ?is gr\p ( foods w\ld come naturally & prop]ly f a physician1 & ! collection & dissem9ation ( ?is in=mation may v prop]ly be includ$ 9 ! "w ( ?is ,c\ncil4 ,z ! products 9 ?is class are us$ ext5sively1 x is n prop] to limit _! adv]tis+ to m$ical j\rnals1 b ! adv]tis+ %\ld be p]mitt$ 9 ! lay press s long z x is conduct$ 9 a mann] compatible ) ! rules ( ! ,c\ncil4 ,! ?ird gr\p includes m$ic9al foods prop]1 su* z pr$ige/$ foods4 ,^! h a relatively l[ food value & are *>act]iz$ by a high alcohol or pres]vative cont5t4 ,!y frequ5tly conta9 /rictly m$ic9al sub/ances1 or food sub/ances = :i* di/9ct !rapeutic prop]ties are claim$4 ,^! products %\ld be us$ only on ! advice ( ! physician1 & ! adv]tisem5ts %\ld be re/rict$ z 9 ! case ( ord9>y m$ic9es4 ,adv]tisem5ts 9 ,=eign ,c\ntries4--,! ,c\ncil deals prim>ily1 9 ! int]e/ ( ! public & ( ! m$ical pr(ession1 ) articles propos$ = admission to ,new & ,non(ficial ,rem$ies1 &1 9 det]m9+ ! /atus ( any article1 mu/ take into consid]ation any /atem5ts made reg>d+ x or any me?od ( adv]tis+ x employ$ by ! manufactur] or 8 au?oriz$ ag5ts or repres5tatives1 :e!r 9 ?is c\ntry or abroad4 ,! ,c\ncil w n reg>d z )9 its scope1 h[ev]1 que/ions conc]n+ ! m>ket+ ( articles 7except ! matt] ( direct adv]tis+ to ! laity & unw>rant$ claims or misrepres5tations7 9 any c\ntry :i* has a public body correspond+ to ?is ,c\ncil4 ,explanation ( ,rule #d3 ,indirect ,adv]tis+ ,matt] ,di/ribut$ ,solely to ,physicians4--,x %\ld be rememb]$ t ! sole int5t ( ?is rule is to protect ! physician1 s t 9 prescrib+ a propriet>y m$ic9e he %all n unconsci\sly adv]tise propriet>y prep>ations4 ,! rule imposes no re/riction on ! legitimate me?ods ( br++ a rem$y to ! att5tion ( ! pr(ession1 su* z adv]tis+ 9 m$ical j\rnals1 circul>s & o!r pr9t$ matt] di/ribut$ solely to physicians4 ,! rule applies only to ! package z x may rea* ! pati5t4 ,nam+ ,diseases on ,labels4--,! nam+ ( diseases on ! label or package is n necess>y1 z is %[n by ! v l>ge numb] ( propriet>y products :i* h be5 successfully introduc$ )\t resort+ to ?is exp$i5t4 ,?is me?od ( popul>iz+ a propriet>y rem$y ) ! laity is mo/ objectionable1 & %\ld n be tol]at$ 9 any =m4 ,9 g5]al1 !rapeutic indications %\ld be omitt$ f ! label & package4 ,! ,c\ncil w n insi/ on ?is po9t1 h[ev]1 :5 su* indications are s giv5 z n to promote self-m$ication1 p>ticul>ly 9 diseases :i* require exp]t diagnosis & sup]vision4 ,x w be consid]$ an infr+em5t ( ! rule if an article be m>ket$ 9 bottles :i* h ! "n ( ! article bl[n into ! glass1 or if o!rwise ! "n or initials or o!r di/9ctive m>k ( ! article is p]man5tly /amp$ on ! conta9]1 on ! article itself1 or is on ! /opp]s or seals4 ,articles :i* are m>ket$ 9 any ( ^! ways are n accept$ = ,new & ,non(ficial ,rem$ies4 ,readily removable labels are n objectionable1 nor is ! p]man5t affix+ ( ! firm's initials or "n to ! trade package if su* initials or "n is n sugge/ive ( ! article4 ,! ,c\ncil does n c\nt5ance ! use ( an accept$ article = adv]tis+ o!r articles :i* h n be5 accept$ by ! ,c\ncil4 ,explanation ( ,rule #e3 ,false ,claims z to ,orig9 ,s\rce4--,no false or mislead+ /atem5t 9 reg>d to an article c be p]mitt$ conc]n+ ! s\rce ( mat]ial f :i* x is made1 or ! p]sons by :om x is made4 ,"s gl>+ frauds ( ?is nature h be5 p]petrat$ 9 ! pa/1 & ?is rule is int5d$ to prev5t su* imposition4 ,explanation ( ,rule #f3 ,unw>rant$ ,!rapeutic ,claims ,!rapeutic ,que/ions4--,?is rule insi/s t ! claims ( manufactur]s or ag5ts conc]n+ ! !rapeutic prop]ties ( _! products mu/ be compatible ) demon/rable facts4 ,manufactur]s w be held responsible = all /atem5ts made or quot$ 9 _! adv]tis+ 8lit]ature0 reg>d+ _! products4 ,recogniz+ ! exi/5ce ( hone/ diff]5ces ( op9ion on _m !rapeutic que/ions1 ! ,c\ncil desires to be lib]al 9 ! application ( ?is rule4 ,x is natural t a manufactur] %\ld be p>tial t[>d 8 own product1 & a mod]ate degree ( emphasis 9 adv]tis+ may n be objectionable4 ,! ,c\ncil1 h[ev]1 w n admit claims :i* are nei!r 9 h>mony ) already accept$ facts nor support$ by acceptable evid5ce4 ,9 d\btful cases ! ,c\ncil consid]s ^! que/ions ) ! advice & coop]ation ( its /aff ( cl9ical consultants4 ,cl9ical ,evid5ce4--,to be acceptable1 ! cl9ical evid5ce mu/ (f] objective data ) su* citation ( au?ority z w enable ! ,c\ncil to confirm ! facts & e/abli% ! sci5tific value ( ! conclusions drawn4 ,cl9ical data are wor?less :5 ! au?or is n cit$4 ,! facts on :i* claims ) reg>d to ! value ( a rem$y are bas$ mu/ h be5 r5d]$ accessible = inve/igation & confirmation by dis9t]e/$ obs]v]s1 ei!r ?r\gh publication or ?r\gh ! records ( a hospital or o!r in/itution4 ,explanation ( ,rule #g3 ,poison\s ,sub/ances ,poisons4--,= ! in=mation ( ! ph>maci/ or disp5s]1 & to enable him to safegu>d ! int]e/s ( ! pati5t & ! physician1 all articles conta9+ su* pot5t ag5ts z ! poison\s alkaloids & o!r organic sub/ances & ! salts ( "s ( ! metals %\ld h ! exact am\nt ( ^! +r$i5ts :i* is conta9$ 9 ! av]age adult dose /at$ on ! label4 ,explanation ( ,rule #h3 ,objectionable ,names 8,co9$0 ,names4--,_m ( ! abuses connect$ ) propriet>y m$ic9es arise f 8co9$0 propriet>y trade names4 ,su* names w n be recogniz$ by ! ,c\ncil unless 9 p>ticul> in/ances ! ,c\ncil %all deem _! use to be 9 ! int]e/ ( public welf>e4 ,9 e su* exception ! burd5 ( pro(1 bo? = e/abli%+ & = cont9u+ ! exception1 lies ) ^? :o m>ket ! product4 ,propriet>y 78,trade07 ,names ,:5 ,p]mitt$4--,9 consid]ation ( ! b5efits :i* may come f ! discov]y ( a !rapeutic ag5t1 ! ,c\ncil conc$es to ! p]son or firm :i*1 by "r ( discov]y1 controls su* a product ! "r to "n x4 ,! ,c\ncil w (f] no opposition to an arbitr>y "n = su* a new product1 provid$ x is n mislead+1 !rapeutically sugge/ive1 or o!rwise subv]sive ( sci5tific ph>macy & !rapeutics4 ,if ! discov]y t a previ\sly kn[n sub/ance has !rapeutic value is deem$ ( suffici5t importance1 ! ,c\ncil may recognize a "n = su* a sub/ance if ! "n is appli$ by ! p]son :o makes ! discov]y2 or1 ) ! cons5t ( ! discov]] or 9 ! abs5ce ( any prote/ on 8 "p1 ! ,c\ncil may recognize a "n appli$ by ! firm :i* fir/ makes su* a product available to physicians4 ,9 ! int]e/ ( rational drug !rapy1 ! ,c\ncil recomm5ds t trade names be co9$ s z to indicate ! pot5t elem5t or con/itu5t4 ,sci5tific ,names4--,:5 ! propriet>y or trade "n = an article is consid]$ insuffici5tly descriptive ( its *emical composition or ph>maceutical "*1 ! ,c\ncil may require z a condition = ! acceptance ( su* articles t a descriptive sci5tific "n satisfactory to ! ,c\ncil appe> on ! labels1 circul>s & adv]tisem5ts = su* an article4 ,= all def9ite *emical sub/ances x is requir$ t ! sci5tific "n be giv5 prom95ce on ! labels1 9 circul>s & adv]tisem5ts4 ,propriet>y ,names = ,unorig9al ,articles4--,propriet>y names w n be recogniz$ = articles :i* are includ$ 9 ! ,u4 ,s4 ,ph>macopeia or ,national ,=mul>y or = uness5tial modifications ( su* articles4 ,nei!r w propriet>y names be recogniz$ = sub/ances or mixtures :i* are describ$ 9 m$ical or ph>maceutical publications4 ,9 ! m>ket+ ( unorig9al articles1 ! legitimate int]e/s ( ! produc] are fully s]v$ by id5tify+ su* products by app5d+ ! "n or initials ( ! manufactur] or ag5t1 or by ! use ( a g5]al br& m>k4 ,no objection w be made by ! ,c\ncil to ! use ( su* br& m>ks1 provid$ t 9 no case %all su* m>k be us$ z a designation = an individual article4 ,= any product :i*1 by reason ( ! abs5ce or lapse ( pat5t rights or = o!r reasons1 is op5 to manufacture by m ?an "o firm1 ! ,c\ncil res]ves ! "r to select a common "n & to provide /&>ds ( id5tity1 purity & /r5g?1 & !n w accept su* article only if x is m>ket$ "u ! title adopt$ z ! ,n4 ,n4 ,r4 "n or ! "n "u :i* su* article 0 introduc$ 7to :i* may be app5d$ ! firm's id5tify+ m>k74 ,n4 ,n4 ,r4 to ,u4 ,s4 ,p4--,:5 an article :i* has be5 accept$ = ,new & ,non(ficial ,rem$ies is admitt$ to ! ,u4 ,s4 ,ph>macopeia or ,national ,=mul>y1 x w be omitt$ f ,new & ,non(ficial ,rem$ies "o ye> aft] su* /&>dization if ! "n ( su* article is us$ 9 ^! /&>ds ei!r z ! ma9 title = ! product or z a synonym4 ,if ! "n "u :i* ! article is describ$ 9 ,new & ,non(ficial ,rem$ies is n us$ 9 ^! books ( /&>ds1 ! propriet>y prep>ation w be reta9$ provid$ ! (ficial "n is giv5 prom95ce on ! labels & 9 ! circul>s & adv]tisem5ts ( su* article4 ,:5 ! ,c\ncil adopts a common "n = an article t has be5 admitt$ "u ano!r "n1 x w be cont9u$ "u ! old] "n only on condition t ! ,c\ncil "n be giv5 prom95ce on ! label & 9 ! circul>s & adv]tisem5ts = su* article4 ,ph>maceutical ,prep>ations & ,mixtures4--,^!1 ) r>e exceptions1 are n orig9al 9 composition & !re is seldom any reason :y !y %\ld be end[$ ) arbitr>y names4 ,on ! contr>y1 x is important t ! prescrib] %\ld be rem9d$ con/antly ( _! pot5t +r$i5ts4 ,!rapeutically ,sugge/ive ,names4--,articles be>+ !rapeutically sugge/ive names w n be accept$ = ,new & ,non(ficial ,rem$ies1 fir/1 because !y are likely to lead physicians into prescrib+ names in/ead ( rem$ies1 & second1 because !y t5d to enc\rage unw>rant$ self-m$ication by ! laity4 ,ev5 if ! "n is at fir/ app>5tly mean+less to ! public1 its mean+ w soon be und]/ood because pati5ts soon le>n ! te*nical names appli$ to _! diseases & symptoms4 ,! prohibition aga9/ !rapeutically sugge/ive names is n appli$ to s]ums1 vacc9es & antitox9s1 because ! accept$ nom5clature ( ! specific organisms us$ 9 _! prep>ation makes ?is unavoidable & because self-m$ication ) !m is improbable4 ,explanation ( ,rule #i3 ,pat5ts1 ,tradem>ks1 ,copyrights1 ,etc4 ,protection4--,?is in=mation is important z a means ( det]m9+ ! legal /atus ( m$ic9al articles & z an aid to _! ready recognition 9 curr5t publications4 ,explanation ( ,rule #aj3 ,unsci5tific & ,useless ,articles ,unsci5tific ,comp\nds4--,! use ( articles :i* are uness5tial modifications ( (ficial or e/abli%$ nonpropriet>y articles is unsci5tific & s]ves no useful purpose4 ,! ,c\ncil w n accept products :i* are sci5tifically uns\nd & :i*1 !re=e1 mu/ be consid]$ useless or inimical to ! be/ int]e/ ( ! m$ical pr(ession & ! public4 ,?is class includes comp\nds or mixtures conta9+ an excessive numb] ( active +r$i5ts2 ^? comp\nds or mixtures ! compon5ts ( :i* are ( no probable assi/ance to "o ano!r1 & ^? articles :i* are ( no !rapeutic value4 ,uness5tial ,modifications ( ,(ficial ,sub/ances4--,! subt]fuge ( obta9+ propriet>y rights ov] an (ficial or e/abli%$ nonpropriet>y product1 by introduc+ uness5tial modifications1 also t5ds to confusion & abuses1 & su* articles w n be admitt$ by ! ,c\ncil4 ,ess5tial & important modifications1 h[ev]1 w receive recognition4 7,! ,c\ncil int]prets ! t]m 8e/abli%$ nonpropriet>y product0 z apply+ to a prep>ation ( any =mula :i* has be5 publi%$ ?r\gh any recogniz$ or reasonably accessible *annel ( publication1 prior to its appropriation or modification by a manufactur]47 ,duplicates ( biologic products accept$ "u ! "n ( ! manufactur]s w n be accept$ "u ! names ( ! di/ributors4 ,,! ,,c\ncil ,,on ,,ph>macy ,,& ,,*emi/ry1 ,,pres5t ,,& ,,future,a ,w4 ,a4 ,puckn]1 ,ph>4,d4 ,secret>y1 ,c\ncil on ,ph>macy & ,*emi/ry ,a ,read be=e ! ,*icago ,m$ical ,society1 ,m>* #bf1 #aiai4 ,! ,_w ,w> m>k$ an epo* 9 ! exi/5ce ( ! ,c\ncil on ,ph>macy & ,*emi/ry1 z x did 9 all human endeavors4 ,! in=mation & exp]i5ce :i* _h be5 accumulat$ by ! ,c\ncil dur+ its ?irte5 ye>s' exi/5ce 0 drawn on by our gov]nm5t1 directly or indirectly1 & x also receiv$ consid]ation 9 ,engl&1 ,france1#a ,belgium1 ,holl&1#b ,italy1#c ,sw$5 & else:]e4 ,9 ! _w wide readju/m5t t has begun1 ! ef=ts ( ! ,c\ncil1 pa/ & pres5t1 w influ5ce ! plans ( ^? :o engage 9 ! manufacture or sale ( m$ic9es1 &1 und\bt$ly1 w be ! inc5tive to ! e/abli%m5t ( simil> bodies 9 o!r c\ntries4 #a 8,new & ,non(ficial ,rem$ies0 9 ,france1 ,=eign ,news1 ,j4 ,a4 ,m4 ,a4 #ga3acca 7,oct4 #ai7 #aiah2 #gj3aghc 7,june #h7 #aiah4 #b ,n$]l4 ,tjds*r4 v4 ,g5eesk4 ,oct4 #e1 #aiah1 p4 #abja4 #c ,an ,italian ,view ( ! ,propriet>y ,evil1 ,=eign ,news1 ,j4 ,a4 ,m4 ,a4 #ga3hdj 7,sept4 #g7 #aiah2 ,! ,c\ncil on ,ph>macy & ,*emi/ry & ! ,patriotic ,m$ical ,league 9 ,italy1 ibid4 #ga3iah 7,sept4 #ad7 #aiah4 ,z secret>y ( ! ,c\ncil almo/ f ! "t ( its organization 9 #aije1d & kn[+ ! "w ( its memb]s & its collaborators1 ,i am firmly conv9c$ t ?is body has des]v$ ! endorsem5t & support giv5 x by ! ,am]ican m$ical pr(ession4 ,i welcome ?is opportunity to pres5t an outl9e ( ! ,c\ncil's pa/ activities & to speak ( "s ( ! problems ( ! future1 because ,i feel assur$ t a k ( its endeavor to improve drug !rapy w increase ! pr(ession's confid5ce 9 ! ,c\ncil & add to ! numb] ( its support]s4 #d ,al?\gh ! ,c\ncil on ,ph>macy & ,*emi/ry 0 e/abli%$ 9 #aije1 x is likely t only a small p]c5tage ( physicians "k j :at ! ,c\ncil is1 or h any conception z to its p]sonnel & its ability to judge ! available evid5ce = propriet>y m$icam5ts4 ,! p]sonnel has *ang$ f "t to "t s9ce #aije4 ,at pres5t its memb]%ip is3 ,c4 ,l4 ,alsb]g1 ,a4,m41 ,m4,d41 *ief ( ! ,bureau ( ,*emi/ry1 ,u4 ,s4 ,dep>tm5t ( ,agriculture1 ,wa%+ton1 ,d4 ,c42 ,r4 ,a4 ,hat*]1 ,ph4,g41 ,m4,d41 pr(essor ( ph>macology1 ,cornell ,univ]sity ,m$ical ,college1 ,new ,york ,city2 ,a4 ,w4 ,hewlett1 ,m4,d41 pr(essor ( m$ic9e1 ,lel& ,/an=d ,junior ,univ]sity ,m$ical ,s*ool1 ,san ,francisco2 ,john ,h[l&1 ,m4,d41 pr(essor ( p$iatrics1 ,johns ,hopk9s ,univ]sity ,dep>tm5t ( ,m$ic9e1 ,baltimore2 ,reid ,hunt1 ,m4,d41 pr(essor ( ph>macology1 ,h>v>d ,univ]sity ,m$ical ,s*ool1 ,bo/on2 ,h5ry ,kraem]1 ,ph4,d41 pr(essor ( ph>macognosy1 ,univ]sity ( ,mi*igan ,college ( ,ph>macy1 ,ann ,arbor1 ,mi*42 ,w4 ,t4 ,longcope1 ,a4,b41 ,m4,d41 ,b>d ,pr(essor ( ! ,practice ( ,m$ic9e1 ,college ( ,physicians & ,surgeons ( ,columbia ,univ]sity1 ,new ,york ,city2 ,g4 ,w4 ,mc,coy1 ,m4,d41 director ( ! ,hygi5ic ,laboratory1 ,unit$ ,/ates ,public ,heal? ,s]vice1 ,wa%+ton1 ,d4 ,c42 ,lafayette ,b4 ,m5del1 ,ph4,d41 ,sc4,d41 pr(essor ( physiologic *emi/ry1 ,%effield ,sci5tific ,s*ool1 ,yale ,univ]sity1 ,new ,hav51 ,conn42 ,f4 ,g4 ,novy1 ,m4,d41 ,sc4,d41 pr(essor ( bact]iology1 ,univ]sity ( ,mi*igan1 ,ann ,arbor1 ,mi*42 ,w4 ,w4 ,palm]1 ,b4,s41 ,m4,d41 associate pr(essor ( m$ic9e1 ,college ( ,physicians & ,surgeons ( ,columbia ,univ]sity1 ,new ,york ,city2 ,l4 ,g4 ,r[ntree1 ,m4,d41 pr(essor ( m$ic9e1 ,univ]sity ( ,m9nesota ,m$ical ,s*ool1 ,m9neapolis2 ,torald ,sollmann1 ,m4,d41 pr(essor ( ph>macology & mat]ia m$ica1 ,m$ical ,dep>tm5t1 ,we/]n ,res]ve ,univ]sity1 ,clevel&2 ,julius ,/ieglitz1 ,ph4,d41 ,sc4,d41 ,*em4,d41 vice *airman ( ! ,c\ncil1 pr(essor ( *emi/ry1 ,univ]sity ( ,*icago1 ,*icago2 ,g4 ,h4 ,simmons1 ,m4,d41 ,,ll4,d41 *airman ( ! ,c\ncil1 editor ( ,! ,j\rnal ( ! ,am]ican ,m$ical ,association1 ,*icago1 & ,w4 ,a4 ,puckn]1 ,ph>4,d41 secret>y ( ! ,c\ncil1 director ( ! ,*emical ,laboratory ( ! ,am]ican ,m$ical ,association1 ,*icago4 ,,! ,,c\ncil',s ,,activities ,organiz$ prim>ily = ! purpose ( putt+ a /op to false decl>ations ) reg>d to ! composition ( propriet>y m$ic9es1 ! ,c\ncil's activities h broad5$ until its "w may be *>act]iz$ z 8a propag&a = ! rational use ( drugs40 ,! foll[+ are "s ( its activities3 #a4 ,new & ,non(ficial ,rem$ies4--,?is is an annual volume1 issu$ by ! ,c\ncil4 ,x describes bo? propriet>y & non(ficial1 nonpropriet>y drugs :i* are deem$ wor?y ( consid]ation by ! m$ical pr(ession4 ,to be admitt$ to ?is book1 a prep>ation mu/ comply ) c]ta9 def9ite rules :i* /ipulate1 9 effect1 t its composition be decl>$1 t no untrue or grossly exagg]at$ claims be made = x1 & t x %all give promise ( hav+ !rapeutic value4 ,) ! exception ( a few :i* are /ill "u consid]ation1 ! ,c\ncil has consid]$ all propriet>ies ^: own]s or accr$it$ ag5ts h reque/$ t an exam9ation ( ! products be made1 & x has admitt$ to ! book ^? :i* 7 f\nd eligible4 ,9 addition1 ! ,c\ncil has exam9$ all ( ! m important or widely exploit$ propriet>ies1 ev5 :5 no exam9ation 0 reque/$1 & x has admitt$ ^? ( ?is gr\p :i* 7 f\nd eligible4 ,fur!r1 ! ,c\ncil has admitt$ to ! book c]ta9 non(ficial1 nonpropriet>y articles :i* seem$ to give promise ( !rapeutic usefulness1 & x has e/abli%$ /&>ds = ! control ( _! id5tity & purity1 & li/$ ^? br&s :i* compli$ ) ^! /&>ds4 ,z mo/ propriet>y m$ic9es are ( a m or less exp]im5tal nature1 !y are accept$ = inclusion 9 ,new & ,non(ficial ,rem$ies only = a limit$ "t--usually a p]iod ( ?ree ye>s4 ,at ! expiration ( ! p]iod ( acceptance1 ea* prep>ation is reexam9$ & reta9$ only if ! claims made = x & ! pres5t day k ( its value p]mit ?is action4 ,s9ce manufactur]s give in=mation only 9 reg>d to _! own products1 ,new & ,non(ficial ,rem$ies gr\ps toge!r articles ( a simil> "*1 & includes 9 ea* case a g5]al discussion ( ! gr\p = ! purpose ( comp>ison1 n only ) ea* o!r1 b also ) ! e/abli%$ or ph>macopeial drugs :i* memb]s ( ! gr\p are int5d$ to supplant4 ,9 brief1 ,new & ,non(ficial ,rem$ies is a book 9 :i* are describ$ prep>ations t h be5 accept$ by ! ,c\ncil4 ,! description includes facts t ! physician %\ld h4 ,x is a book t %\ld be 9 ! h&s ( e physician :o prescribes m$ic9es1 & :o wi%es to "k ! facts reg>d+ ! newe/ rem$ies4 ,x is ! only book 9 :i* he c f9d in=mation relative to propriet>y m$ic9es t are wor?y ( 8 patronage4 ,x w protect ! physician :o makes use ( x aga9/ ! wiles ( ! promot]s ( products n wor?y ( 8 patronage4 ,x w\ld c]ta9ly be ( use to ! physician :5 ! detail man calls on him1 = if he 7 be+ importun$ to prescribe or use samples ( some?+ :i* he _h n h]et(ore us$ & :i* he 0 unable to f9d 9 ,n4 ,n4 ,r41 he might ask ! detail man :y4 ,9 ! nature ( ?+s few physicians are suffici5tly exp]t 9 *emi/ry & alli$ sci5ces to be able un]r+ly to discrim9ate betwe5 ! true & ! false z reg>ds _m prep>ations t he is ask$ to prescribe4 #b4 ,! ,reports ( ! ,c\ncil on ,ph>macy & ,*emi/ry4--,a m$icam5t may be inadmissible to ,new & ,non(ficial ,rem$ies = v>i\s reasons2 x may be wor?less or irrational1 its composition may be secret or indef9ite1 or x may be exploit$ "u exagg]at$ or unw>rant$ claims or 9 a way o!rwise detrim5tal to ! public heal? & sci5tific m$ic9e4 ,( ^! v>i\s reasons :i* make an article unacceptable1 ! manufactur] obvi\sly may remove all except ! fir/1 viz41 wor?lessness or irrationality4 ,consequ5tly1 a prep>ation :i* has be5 pres5t$ = admission is n def9itely reject$ until aft] its proprietor has be5 in=m$ ( ! objections to 8 product & has fail$ to br+ ! prep>ation 9 con=mity ) ! ,c\ncil's rules4 ,:5 a prep>ation is f\nd def9itely inadmissible to ,new & ,non(ficial ,rem$ies1 t is1 :5 ! proprietor _c or w n make x acceptable1 ! ,c\ncil prep>es a report = publication4 ,^! reports are s5t = publication to ,! ,j\rnal ( ! ,am]ican ,m$ical ,association1 & lat] publi%$ 9 ! annual 8,reports ( ! ,c\ncil on ,ph>macy & ,*emi/ry40 ,! m important ( ^! are also publi%$ 9 ! book1 8,! ,propag&a = ,re=m 9 ,propriet>y ,m$ic9es40 #c4 ,useful ,drugs4--,s9ce ! dom9ation ( propriet>y m$ic9es1 :i* 0 ret>d+ m$ical advance & ?reat5+ !rapeutic *aos1 _h be5 made possible only by ! insuffici5t & ineffici5t in/ruction giv5 9 m$ical s*ools 9 subjects hav+ to d ) drugs1 ! ,c\ncil appo9t$ a ,committee on ,m$ical ,tea*+ to secure ! coop]ation ( tea*]s 9 mat]ia m$ica1 ph>macology & relat$ bran*es4 ,?is committee has endeavor$ to effect an improvem5t 9 ^! c\rses ( in/ruction4 ,"o ( ! results ( ?is "w 0 ! selection ( a li/ ( drugs to s]ve z a basis ( mat]ia m$ica in/ruction & ?us insure t m$ical /ud5ts %all be bett] in=m$ ) reg>d to ! !rapeutic wor? ( a few well e/abli%$ drugs1 r ?an1 z 9 ! pa/1 leav+ s*ool ) a smatt]+ ( k ab\t _m drugs4 ,! outcome ( ^! ef=ts is ! publication ( 8,useful ,drugs10 a concise b ?or\gh & up-to-date discussion ( ! actions1 uses & dosage ( ! m important drugs4 ,! li/ ( drugs pres5t$ 9 ?is book is n[ ! basis ( in/ruction 9 _m s*ools2 & _m /ate exam9+ bo>ds are conf9+ _! mat]ia m$ica que/ions to ! drugs 9 ! li/4 #d4 ,epitome ( ! ,u4 ,s4 ,p4 & ,n4 ,f4--,to enc\rage ! use ( (ficial drugs & to make available an e/imate ( _! !rapeutic value1 a committee ( ! ,c\ncil prep>$ an ab/ract ( ! ,u4 ,s4 ,ph>macopeia & ! ,national ,=mul>y4 ,?is booklet1 ! 8,epitome ( ! ,u4 ,s4 ,ph>macopeia & ,national ,=mul>y10 pres5ts ^? portions ( ^! books :i* are ( int]e/ to physicians1 & 9 addition1 gives a concise /atem5t ( ! !rapeutic usefulness ( ! drugs & prep>ations describ$ 9 !m4 #e4 ,pat5t ,law ,re=m4--,"s ( ! wor/ abuses connect$ ) ! exploitation ( propriet>y m$ic9es h be5 made possible by our pat5t & tradem>k laws & ! me?od ( _! int]pretation & en=cem5t4 ,! ,c\ncil1 !re=e1 appo9t$ a committee to /udy ^! laws & ! v>i\s propositions advanc$ = _! improvem5t4 ,?is committee has publi%$1 f "t to "t1 reports on v>i\s phases ( our pat5t & tradem>k laws & rec5tly summ>iz$ ^! reports 9 an address#e s5t to ! commission] ( pat5ts & ! int]e/$ congressional committees4 ,x is hop$ t by means ( ^! reports physicians w be enabl$ to give intellig5t support to a revision ( ! pat5t & tradem>k laws :5 legislation is propos$4 #e ,ne$ = ,pat5t ,law ,revision1 ,a4 ,m4 ,a4 ,c\ncil on ,ph>macy & ,*emi/ry ,reports1 #aiag1 p4 #acj4 #f4 ,!rapeutic ,rese>*4--,?r\gh its ,committee on ,!rapeutic ,rese>*1 & ) ! aid ( funds provid$ by ! ,bo>d ( ,tru/ees ( ! ,am]ican ,m$ical ,association1 ! ,c\ncil has enc\rag$ ! inve/igations ( que/ions :i* might lead to a bett] und]/&+ ( ! action ( drugs4 ,^! inve/igations are br\ght toge!r 9 ! annual reports ( ! ,committee on ,!rapeutic ,rese>*1 & are an important addition to our k ( drug action4 ,9 ! pa/1 ! ,c\ncil has 9 p>ticul> enc\rag$ ! inve/igation ( ! action & !rapeutic value ( widely us$ drugs reg>d+ :i* our k is /ill unsatisfactory4 ,^! inve/igations h includ$ a /udy ( ! action ( /ry*n9 9 c>diac disease1 a comp>ison ( ! action ( absorption & excretion ( iodid prep>ations1 a /udy ( ! ph>macology ( ! opium alkaloids1 etc4 ,appreciat+ t ! available k ( propriet>y drugs is "o sid$ 9 t x comes f inve/igations made by int]e/$ ph>maceutical conc]ns or f inve/igations made at ! in/igation ( ^! firms1 ! ,c\ncil is plann+ a compreh5sive /udy ( _m ( ! syn!tic drugs t h ga9$ "s vogue dur+ rec5t ye>s4 ,,! ,,future ,m$ical rese>*1 & effici5t in/ruction 9 !rapeutics & relat$ subjects1 spell a dim9i%+ influ5ce ( comm]cial m$ic9e ov] rational !rapeutics4 ,! fact t ! pres5t %ortage ( ,g]man syn!tics has n h&icapp$ s]i\sly ! practice ( m$ic9e %\ld be a lesson to ,am]ican physicians = _m ye>s to come4 ,on ! o!r h&1 x mu/ be rememb]$ t ! publicity giv5 to ! reports ( ! ,c\ncil & to o!r contributions t[>d rational !rapeutics by ,! ,j\rnal ( ! ,am]ican ,m$ical ,association1 ! j\rnals ( ! /ate organizations1 & a few p]sonally own$ publications1 is z no?+ :5 comp>$ ) ! p]si/5t & wide publicity giv5 to ! propag&a ( ! propriet>y h\ses4 ,:ile a report sett+ =? ! objections to a propriet>y is publi%$ b once1 ! firm's laudatory pron\ncem5t goes =? aga9 & aga9 until ! ,c\ncil's report is completely ov]:elm$ & =gott54 ,manufactur]s ( propriet>ies n only keep 9 close t\* ) ! practic+ physician by means ( h\se organs1 special 8lit]ature10 or by travel+ repres5tatives1 b _m ( ! firms1 ?r\gh ! m]itori\s l9es ( pills1 tablets1 t9ctures1 etc41 :i* !y put out1 also obta9 & hold ! good w & confid5ce ( a l>ge proportion ( ! m$ical pr(ession4 ,fur!rmore1 "s ( ^! firms may ga9 ! confid5ce ( ! m$ical pr(ession ?r\gh ^! high grade ph>maceuticals1 & c]ta9 ( _! propriet>ies may be ( di/9ct !rapeutic value b may fail to be acceptable = ,new & ,non(ficial ,rem$ies1 because !y d n con=m to ! reasonable rules ( ! ,c\ncil4 ,^! firms d n f9d x pr(itable to =ce ! sale ( _! regul> nonpropriet>y ph>maceuticals by unw>rant$ claims or objectionable me?ods1 yet !y may consid] x good bus9ess to m>ket c]ta9 propriet>y products by means ( claims :i* are extravagant & )\t w>rant1 & :i* w lead to indiscrim9ate use by ! pr(ession & ! public4 ,9 a ^w1 :]e !re is "o doll> sp5t on behalf ( rational m$ic9e1 ?\s&s are sp5t = ! purpose ( increas+ ! sale ( prep>ations :i* directly or indirectly are a detrim5t to ! public heal?1 to m$ic9e1 & to ! pocketbook4 ,t ! day ( ! secret no/rum ( ! pseudo-*emical company is n yet pa/ is well illu/rat$ by ! rec5t introduction ( an ass]t$ arsph5am9 prep>ation call$ 8,syphilodol40 ,! ,a4 ,m4 ,a4 ,*emical ,laboratory prov$ "o =m ( ?is ass]t$ ,fr5* discov]y to be ess5tially a pill ( m]cur\s iodid4 ,ano!r =m ( ,syphilodol 7= intrav5\s adm9i/ration7 _h all ! *>act]i/ics ( wat]1 & appe>$ devoid ( any pot5t +r$i5t4 ,?\gh ! adv]tis+ s5t out by ! promot]s 9 reg>d to its composition 0 suspici\sly evasive1 ! ,ill9ois ,m$ical ,j\rnal publi%$ an adv]tisem5t ( 8,syphilodol10 :i*1 possibly by a co9cid5ce1 appe>$ above an appeal to 8,our ,read]s0 to use w>es adv]tis$ 9 t j\rnal4 ,:ile su* rank deceptions z 8,syphilodol0 are n common1 !re are m subtle deceptions t are ev5 m dang]\s4 ,types ( widely exploit$ rem$ies ( today comprise s-call$ e?ical specialties compos$ ( well kn[n & e/abli%$ drugs 7) 8jok]s0 hidd5 away some:]e7 or prep>ations :i* h a plausibly fasc9at+ pseudo-sci5tific backgr\nd ( radiant en]gy1 colloidal *emi/ry1 nonspecific prote9 reaction1 or some?+ ( ! sort4 ,! latt] class ( prep>ations 9 p>ticul> appeal to physicians :o are /riv+ h>d to keep pace ) mod]n sci5ce4 ,exposure ( _! fallacies requires mo/ c>eful consid]ation on ! "p ( ! ,c\ncil4 ,progress t[>d a rational & sci5tific drug !rapy mu/ cont9ue1 &1 !re=e1 x is important t ! ,c\ncil on ,ph>macy & ,*emi/ry %\ld cont9ue to make ! inve/igation ( propriet>y m$ic9es its *ief "w4 ,inve/igation ( a propriet>y m$ic9e1 h[ev]1 & a report ( su* inve/igation are ( value 9 direct ratio only to ! numb] ( physicians :o read ! report1 endorse x & act 9 accordance ) its conclusions4 ,9 ord] t y may det]m9e to :at ext5t ^? prep>ations :i* are admitt$ to ,new & ,non(ficial ,rem$ies des]ve y\r int]e/ & confid5ce1 x w be wor? :ile briefly to outl9e ! rules :i* gov]n ! ,c\ncil 9 ! admission ( articles to ,new & ,non(ficial ,rem$ies4 ,,rules ,,gov]n+ ,,! ,,acceptance ,,( ,,articles ,,= ,n4 ,n4 ,r4 ,composition4--,rules #a & #b1 & 9 a measure #e1 #g1 & #i1 deal ) ! composition ( articles4 ,rule #a requires t ! quantitative composition ( an article be furni%$ ! ,c\ncil = publication4 ,rule #b requires t ! manufactur] furni% me?ods :]eby ! composition ( products t are def9ite *emicals or ! pot5t con/itu5ts ( mixtures may be det]m9$4 ,! ,c\ncil does n require t ! process ( manufacture ( an article be decl>$ unless ?is becomes necess>y 9 ord] to judge its composition4 ,rule #e requires t /atem5ts ) reg>d to ! orig9 & s\rce ( an article %all be tru?ful4 ,rule #g requires t = ! guidance ( ! disp5s]1 ! am\nts ( poison\s +r$i5ts ( a prep>ation be plac$ on ! label4 ,rule #i requires t if pat5t rights are claim$ = a product1 ! ,c\ncil be in=m$ on ?is po9t4 ,t x is n only ! "r b also ! duty ( ! physician to "k ! composition ( :at he prescribes = 8 pati5ts is s g5]ally admitt$ t few h attempt$ to m>ket prep>ations ( av[$ly secret composition4 ,:5 ! ,c\ncil fir/ began its "w1 x 0 common to see *emical =mulas or /atem5ts ( composition publi%$ :i* a *emi/ or a ph>maci/ 0 able to pron\nce at a glance z impossible4#f ,x 0 n unusual to f9d t ! promot] publi%$ 8a =mula0 = 8 prep>ation1 r ?an 8! =mula40#g ,today1 h[ev]1 a m prud5t1 if n m hone/1 c\rse is pursu$4 ,?is gives a 8=mula0 :i* is correct s f> z x goes1 b :i* fails to divulge ! actual composition ( a prep>ation4 ,:5 x is consid]$ t _m physicians are n any too conv]sant ) ! *emi/ry & ph>macy ( drugs1 x is n surpris+ t "s adm9i/]$ ! propriet>y 8,v5>s510 reg>d+ ! composition ( :i* !y _h only ! vague /atem5t t x 0 8444 a comp>atively nontoxic organic ars5ic comp\nd1 #j4f gm4 repres5t+ #bdg mg4 7#c-c_/d gra9s7 ( metallic ars5ic 9 *emical comb9ation 4440 9 ! belief t a prep>ation simil> to t fir/ introduc$ z salv>san 0 be+ us$4 ,t 8,v5>s50 conta9$ its ars5ic z sodium cacodylate--a notori\sly inactive /ate ( comb9ation--does n ju/ify ! intrav5\s adm9i/ration ( a drug ( unkn[n composition4 #f ,puckn]1 ,w4 ,a43 ,! ,abuse ( ,*emical ,=mulas1 ,reports ,a4 ,m4 ,a4 ,*emical ,laboratory #c3g1 #aiaj4 #g ,! ,=mula = ,glyco-,?ymol9e1 ,j4 ,a4 ,m4 ,a4 #eb3adg 7,jan4 #i7 #aiji4 ,:ile = ! pres5t x probably is n feasible to require1 on ! "p ( ^? :o manufacture m$ic9al prep>ations1 su* pr(essional tra9+ z is requir$ ( ^? :o prescribe & ^? :o disp5se !m1 x c]ta9ly is n too mu* to require1 z does ,rule #b1 t a manufactur] %all be able to demon/rate t 8 prep>ation has ! composition claim$ = x4 ,nor is x suffici5t = him to "k t ! +r$i5ts claim$ z con/itu5ts 7 us$ 9 ! manufacture4 ,! fallacy ( 8 me?od ( reason+ 0 furni%$ by ! physician :o report$ t he _h p]sonally add$ ! requir$ am\nt ( m]curic iodid = a bat* ( 8,m]col0 :i*1 nev]!less1 0 devoid ( m]cury4#h ,acceptance ( ?is rule by manufactur]s w p]mit physicians to h a m accurate k ( ! composition ( prep>ations su* z 8,taka-,dia/ase0#i & 8,iodeol04#aj #h ,hunt1 ,reid1 & ,seidell1 ,a!rton3 ,h[ell's ,m]col1 ,j4 ,a4 ,m4 ,a4 #eb3bbe 7,jan4 #af7 #aiji4 ,h[ell's ,m]col ,aga93 ,ano!r ,analysis ,fails to ,reveal ! ,pres5ce ( ,m]cury1 ,j4 ,a4 ,m4 ,a4 #eb3aeie 7,may #ae7 #aiji4 #i ,taka-,dia/ase & ,liquid ,taka-,dia/ase3 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry1 ,j4 ,a4 ,m4 ,a4 #ei3ej 7,july #f7 #aiab4 #aj ,iodeol & ,iodagol3 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry1 ,j4 ,a4 ,m4 ,a4 #fi3agbe 7,nov4 #ag7 #aiag4 ,a requirem5t simil> to t ( ,rule #e is conta9$ 9 ! ,f$]al ,food & ,drugs ,act & s no objection has be5 made to ?is rule :i* requires a tru?ful /atem5t ( ! orig9 & s\rce ( articles4 ,an illu/ration = ! ne$ ( ! rule 0 furni%$ by ! "o "t popul> 8,v9 ,m>iani0#aa :i*1 ?\gh v ,fr5* 9 its makeup1 0 f\nd to be l>gely ( ! 8made 9 ! ,unit$ ,/ates0 v>iety ( tipple4 #aa ,v9 ,m>iani3 ,(ficial ,report ( ,c\ncil on ,ph>macy & ,*emi/ry--,) ,comm5ts1 ,j4 ,a4 ,m4 ,a4 #dg3agea 7,nov4 #bd7 #aijf4 ,! issuance ( a pat5t = a m$ic9al product does n prove t su* a product pres5ts a discov]y or t its own] is entitl$ to a tempor>y monopoly1 yet x is only fair to physicians & to o!r manufactur]s t notice ( su* pat5t claims be giv54 ,h5ce1 ! ,c\ncil publi%es 9 ,new & ,non(ficial ,rem$ies ! in=mation be>+ on ?is po9t4 ,lay ,adv]tis+4--,rules #c & #d provide aga9/ ! recognition ( articles t are adv]tis$ to ! public directly or indirectly1 exempt+ f ?is requirem5t prep>ations :i* ! ,c\ncil believes are safe to be s adv]tis$4 ,x has be5 held ) "s ju/ice t c]ta9 %otgun propriet>ies are pur*as$ by ! public ) z mu* circumspection z !y are ord]$ by ^? physicians :o are addict$ to ! prescrib+ ( !m2 b ev5 ! exploit]s ( ^! mixtures h n d5i$ t ! use ( m$ic9es by ! public on its own initiative is surr\nd$ ) _m objections4 ,h5ce ! practice ( self m$ication %\ld n be enc\rag$ by prescrib+ or us+ ^? prep>ations adv]tis$ = public use4 ,! only objection to ! rule has come f a firm :i* m>kets a br& ( liquid petrolatum1 ! ,/&>d ,oil ,company ( ,indiana4 ,! ,c\ncil has consid]$ ! "q ( exempt+ simple laxatives f ! re/rictions ( ,rules #c & #d z x has exempt$ antiseptics & nonm$ic9al foods4 ,! conclusion 01 h[ev]1 t ! excessive use ( a simple laxative l a liquid petrolatum1 :5 prompt$ by newspap] exploitation1 is likely to be detrim5tal to heal? by ov]use z well z by misuse4 ,! indirect adv]tisem5t to ! public1 :i* ,rule #d provides aga9/1 has be5 ! means ( induc+ ! ext5sive lay use ( 8,antikamnia10 8,bromidia0 & 8,fell[s' ,syrup40 ,naturally ,rule #d has be5 bitt]ly oppos$ by mo/ propriet>y firms4 ,argu+ t _m physicians disp5se _! own drugs1 ph>maceutical firms h insi/$ t e m$ic9al prep>ation %\ld be> on its label1 n only ! dose ( ! prep>ation1 b also a /atem5t ( ! diseases 9 :i* ! article is indicat$4 ,:e!r manufactur]s anticipat$ ! pr(ession's res5tm5t t[>d ! claim t physicians det]m9e ! treatm5t & p]haps ! diagnosis by means ( ! /atem5ts on labels1 or because ! ,%irley am5dm5t to ! ,food & ,drugs ,act makes ! proprietor responsible = !rapeutic claims on ! label ( a m$ic9e1 x is a fact t few] prep>ations ?an =m]ly ne$ to be refus$ on acc\nt ( infr+em5t on ?is rule4 ,9 fact1 "s ?or\ghly objectionable propriet>ies make a %[ ( be+ 8e?ical0 by omitt+ all !rapeutic discussion f ! labels ( _! prep>ations4 ,!rapeutic ,claims4--,rule #f makes ineligible = ,new & ,non(ficial ,rem$ies any articles reg>d+ :i* ! manufactur] or 8 ag5ts make unw>rant$1 exagg]at$ or mislead+ /atem5ts z to ! !rapeutic value4 ,recogniz+ ! long e/abli%$ cu/om ( !rapeutic exagg]ation1 x has be5 mo/ difficult to det]m9e ! degree ( cons]vatism :i* might ) fairness be requir$ ( a manufactur]4 ,9 view ( ! common acceptance ( individual impressions z dep5dable evid5ce1 x is (t5 almo/ emb>rass+ to decl>e z incompet5t ! /atem5t ( "s well mean+ & all-too-k9d-he>t$ doctor4 ,h[ev]1 z ! pitfalls ( haphaz>d cl9ical trials become bett] kn[n & ! physician's mi/ru/ ( gl[+ acc\nts ( m>vel\s cures m outspok51 ! manufactur]s' claims w be m mod]ate4 ,nom5clature4--,7 x possible to enact & en=ce a law :i* w\ld oblige manufactur]s to sell _! m$ic9al products "u prop]ly descriptive names & :i* w\ld make x illegal = a physician to prescribe x unless he und]/ood ! mean+ ( su* prop]ly descriptive titles1 !n ! ,c\ncil might safely disb&4 ,9 t case1 physicians w\ld discont9ue ! use ( mo/ propriet>y prep>ations 9 favor ( e/abli%$ drugs1 & successful newcom]s might ea* ye> be c\nt$ on ! f+]s ( "o h&4 ,su* a rational nom5clature is n to be ?\ght (1 at lea/ 9 our g5]ation4 ,rule #h requires t ! "n ( an article %all n be mislead+1 t x %all n be !rapeutically sugge/ive1 & t e/abli%$ drugs %all n be disguis$ by fanciful titles4 ,x recognizes ! "r ( discov]]s ( new drugs to "n _! discov]ies1 & int]poses no objection to arbitr>y names = su* products s long z su* names are n mislead+ or d n sugge/ ! !rapeutic uses ( ! products4 ,z ! rule provides aga9/ ! recognition ( co9$ names = e/abli%$ nonpropriet>y drugs1 s x requires t mixtures ( drugs %all be> names descriptive ( _! composition4 ,x w\ld be a long /ep =w>d if physicians w\ld recognize m fully ! objections to ! _m propriet>ies :i* h1 z _! only po9t ( orig9ality1 a non-descriptive "n = an old drug or a mixture ( well kn[n drugs4 ,x is an enc\rag+ sign t ! ,f$]al ,trade ,commission1 :5 issu+ lic5ses = ! manufacture ( syn!tic drugs introduc$ "u ,g]man pat5ts1 /ipulat$ t all manufactur]s au?oriz$ to make a giv5 drug %all use ! same "n = x4 ,irrational ,articles4--,rule #aj provides aga9/ ! recognition ( an article :i*1 because ( its composition1 is useless or inimical to ! be/ int]e/s ( ! public & m$ical pr(ession4 ,?is rule excludes m$icam5ts :i* 7#a7 are uness5tial modifications ( e/abli%$ articles1 or 7#b7 are ( no !rapeutic value or 7#c7 are irrational4 ,) reg>d to ! recognition ( mixtures or comp\nds conta9+ two or m active +r$i5ts1 ! ,c\ncil requires t ! manufactur] e/abli% ! rationality ( its comb9ation4 ,! rule has prev5t$ ! recognition ( _m unnecess>y s-call$ e?ical specialties4 ,?\gh a mass ( te/imonials 0 (t5 to be _h = !m1 ^! conta9$ no evid5ce t ! mixture 0 sup]ior to its pot5t +r$i5t1 or t its !rapeutic effect _h be5 det]m9$4 ,t !re is a heal?y t5d5cy to use s+le drugs = _! def9ite action & to disc>d comb9ations 7be !y %otgun propriet>ies or 8mix$0 vacc9es7 is p]haps be/ illu/rat$ by ! fact t at ! la/ revision ( ! ,u4 ,s4 ,ph>macopeia a consid]able numb] ( complex antiquities 7 omitt$ f t book4 ,feel+ confid5t t ?is meets ) ! endorsem5t ( ! pr(ession1 ! ,c\ncil is exam9+ m critically ! evid5ce = ! value ( ph>maceutical mixtures4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,may #aj1 #aiai47 8,,accept$ ,,by ,,! ,,c\ncil ,,on ,,ph>macy ,,& ,,*emi/ry0 ,"u ! caption giv5 above1 ! ,j\rnal ( ! ,miss\ri ,/ate ,m$ical ,association1 9 its ,july issue1 speaks editorially z foll[s3 ,! ,c\ncil on ,ph>macy & ,*emi/ry ( ! ,am]ican ,m$ical ,association is a dep>tm5t ( our national organization t has n receiv$ ! plaudits & encomiums ( a wildly joy\s m$ical pr(ession nor ! grateful praises ( ! en?usia/ic manufactur] ( ph>maceuticals4 ,! ,c\ncil seems inde$ to be ! unlov$ *ild ( ! entire family ( subsidi>y bodies ( ! association4 ,p]haps ! reason = ?is may be f\nd 9 ! "* ( its duties1 = ! ,c\ncil mu/ expose fraud1 sometimes 9 high places1 & protect ! physician f be+ dup$ by av>ici\s p]sons & by p]sons :o are !mselves sometimes ! victims ( _! own cr$ulity4 ,x ?us happ5s t ! sale ( "s propriet>y article previ\sly held 9 high e/eem by ! practition] proves valueless1 p]haps ev5 fraudul5t4 ,! practition]1 h[ev]1 may h cr$it$ mu* ( 8 success 9 treat+ c]ta9 conditions to t prep>ation & ! mak] has _h success 9 accumulat+ doll>s f its sale & bo? p>ties emit a l\d & vici\s ro> aga9/ ! ,c\ncil1 because !y bo? lose money4 ,nobody wants to be 8protect$0 aga9/ mak+ money--make x hone/ly1 if possible1 b make x--b ?is black %eep among ! ,c\ncils ( ! ,am]ican ,m$ical ,association insi/s on _! mak+ _! money hone/ly6 ,despite _m ob/acles ?r[n into its pa?1 ! ,c\ncil on ,ph>macy & ,*emi/ry has s]5ely pursu$ its allott$ tasks1 correct$ its mi/akes1 improv$ its me?ods1 & today /&s z ! only m$ium to :i* ! hone/ physician may turn = in=mation--n mis9=mation--reg>d+ propriet>y articles4 ,dur+ ! w> ! ,c\ncil & ! *emical laboratory 7 9 close coop]ation ) ! ,surgeon-,g5]al's ,(fice1 te/+ & inve/igat+ e article (f]$ to ! gov]nm5t = ! treatm5t ( sick soldi]s4 ,! v>iety & ! numb] ( faki% & fraudul5t /uff (f]$ to ! ,surgeon-,g5]al 0 a pitiable exhibit ( ! m5tal gymna/ics ( "s p4 ,j n[ ! ,c\ncil & ! laboratory h a new & important field be=e !m1 i4 e41 to protect ! physicians aga9/ wor?less & useless s]ums1 vacc9es & syn!tics4 ,x w be ! ,c\ncil's unpleasant duty to expose ! fraudul5t & useless among ^! articles & /amp tru? on ^? f\nd wor?y4 ,we seem to h w&]$ f ! topic 9 our caption1 b n s 9 reality1 because ! burd5 ( our ?\ght is to l5d our influ5ce to ! spread ( ! motto ( ! ,adv]tis+ ,clubs ( ! ,_w1 namely1 8,tru? 9 ,adv]tis+40 ,x is our purpose to /imulate a l>g] degree ( en?usiasm = ! "w ( ! ,c\ncil on ,ph>macy & ,*emi/ry & ! ,*emical ,laboratory1 a m g5]\s fl[ ( inquiries conc]n+ articles unfamili> to ! physician1 & p>ticul>ly to urge t ! words 8,accept$ by ! ,c\ncil on ,ph>macy & ,*emi/ry ( ! ,am]ican ,m$ical ,association0 be pr9t$ on ! label & on all adv]tis+ circul>s ( propriet>y articles t h be5 admitt$ to ,new & ,non(ficial ,rem$ies4 ,!n1 :5 pamphlets & circul>s are receiv$ by physicians !y w read ! /atem5ts ( manufactur]s ) sympa!tic und]/&+ & ) full confid5ce 9 ! v]ity ( ! decl>ations4 ,! importance ( creat+ j t sort ( receptivity 9 ! m9d ( ! prospective buy] is s well kn[n to ! a/ute publicity exp]t t x is ne$less = u to dwell on its advantages4 ,e propriet>y article adv]tis$ 9 our j\rnal1 9 ,! ,j\rnal ( ! ,am]ican ,m$ical ,association1 & 9 ! o!r /ate association j\rnals1 z well z 9 sev]al well-edit$ privately own$ j\rnals1 does 9 effect say to ! read] t ! articles s adv]tis$ are accept$ by ! ,c\ncil because only propriet>y articles s accept$ are accept$ by u4 ,! fact is fur!r ackn[l$g$ :5 ^! firms are p]mitt$ to exhibit _! goods at our annual sessions = aga9 ! rule is en=c$ t only propriet>y articles :i* h be5 approv$ by ! ,c\ncil may be plac$ on display4 ,:y n complete ! circle ( ideas--x w\ld n be a 8vici\s circle0--by pr9t+ on labels1 9 adv]tisem5ts & circul>s1 ! words3 8,accept$ by ! ,c\ncil on ,ph>macy & ,*emi/ry08--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,aug4 #b1 #aiai47 ,,help+ ,,! ,,c\ncil ,if !y 7 built t way1 ! memb]s ( ! ,c\ncil on ,ph>macy & ,*emi/ry ( ! ,am]ican ,m$ical ,association might become disc\rag$ at ! app>5t indiff]5ce ( _m memb]s ( ! m$ical pr(ession to _! ef=ts4 ,!re are _m physicians :o1 :ile figuratively patt+ ! ,c\ncil on ! back1 actually d no?+ to aid its ef=ts4 ,on ! o!r h&1 !re are m5 9 ! pr(ession :o give ! ,c\ncil active support in/ead ( m]ely passive appreciation4 ,! lett] t foll[s 0 writt5 by su* a man to a ph>maceutical conc]n3 ,i am receiv+ circul> adv]tis+ f y conc]n+ ---- ---- solution1 & ,i am writ+ to sugge/ t until ^! products h be5 approv$ by ! ,c\ncil on ,ph>macy & ,*emi/ry ( ! ,am]ican ,m$ical ,association1 y are wa/+ y\r po/age on ! practice4 ,aside f ! fact t ^! products d n appeal to me p]sonally1 ,i feel t ,i am n 9 a position to judge ! value ( su* products & ,i dep5d entirely on ! l>ge cl9ical opportunities ( ! ,c\ncil on ,ph>macy & ,*emi/ry ( ! ,am]ican ,m$ical ,association 9 addition to _! laboratory facilities1 9 su* matt]s z ^!4 ,i may1 !re=e1 ) all due respect1 sugge/ t 444 x w pay y to elim9ate my "n f y\r mail+ li/4 ,! memb]s ( ! ,c\ncil on ,ph>macy & ,*emi/ry are work+ week 9 & week out )\t remun]ation4 ,few appreciate h[ mu* ^! sci5tific m5 are do+ = rational !rapeutics2 few] /ill realize h[ mu* has be5 accompli%$ ?r\gh _! ef=ts1 or h[ mu* m c\ld be accompli%$ if e physician :o at lea/ believes 9 ! "w ( ! ,c\ncil w\ld give x 8 full support4--7,editorial f ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #f1 #aibj47 ,,delays ,,9 ,,pass+ ,,on ,,products ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has adopt$ ! foll[+ report & au?oriz$ its publication4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,! ,c\ncil frequ5tly receives inquiries--"s ( !m accompani$ by expressions ( impati5ce--conc]n+ articles1 reports on :i* appe> to be delay$4 ,x !re=e seems advisable to make a /atem5t ( "s ( ! factors :i* ent] into ?is problem4 ,! ,c\ncil fully realizes ! importance ( giv+ prompt in=mation to ! pr(ession ) reg>d to propriet>y m$ic9es "u consid]ation4 ,x !re=e acts z soon z suffici5t in=mation is available to ju/ify a def9ite judgm5t1 & publi%es its conclusions z soon z possible4 ,:5 adequate in=mation is available at ! outset1 !re is no delay 9 ! publication ( ! ,c\ncil's conclusions4 ,un=tunately1 b v naturally1 !re are _m cases 9 :i* ! in=mation available at ! "t ! product is submitt$ is n suffici5t to ju/ify ! ,c\ncil 9 com+ to def9ite conclusions = or aga9/ ! prep>ation4 ,9 "s cases ! manufactur] possesses ! requir$ in=mation1 b to obta9 x f him takes "t2 9 o!r cases ! manufactur] does n possess ! in=mation--p]haps he did n realize ! inadequacy ( 8 evid5ce until ! subject 0 br\ght to 8 att5tion by ! ,c\ncil4 ,su* cases might be dealt ) 9 ei!r "o ( two ways3 ,! ,c\ncil might at once reject ! article because ! claims = x are n support$ by adequate evid5ce2 or1 ! ,c\ncil might susp5d judgm5t & give ! manufactur] an opportunity to supply ! in=mation4 ,! fir/ me?od--imm$iate rejection--w\ld obvi\sly be felt by manufactur]s z a h>d%ip4 ,to af=d ! fulle/ possible opportunity = ! pres5tation ( ! case1 ! ,c\ncil foll[s ! second me?od2 t is1 x susp5ds judgm5t & )holds publication ( a report until reasonable "t has be5 af=d$ = furni%+ ! requir$ in=mation1 provid$ ! manufactur] or ag5t appe>s to be mak+ hone/ & dilig5t ef=ts to supply x4 ,! collection & compilation ( su* in=mation is sometimes a l5g?y process1 especially :5 ! products are ( =eign manufacture4 ,al?\gh x w\ld be easi] = ! ,c\ncil to r5d] an imm$iate decision ?an to assi/ manufactur]s to supply ! data necess>y = ! =mation ( an au?oritative judgm5t1 ! ,c\ncil _c yield to importunities = ha/y action4 ,x mu/ rely on ! m$ical pr(ession to be> 9 m9d t ! "* ( a product "u consid]ation by ! ,c\ncil has n yet be5 det]m9$4 ,! ,c\ncil holds t1 dur+ ?is /age1 a product is suitable1 at mo/1 = exp]im5tal use4--7,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiae1 p4 #aai47 ,,coop]ation ,,( ,,! ,,ph>maceutical ,,h\ses ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,9 reply to ! sugge/ion made la/ ye> by ,presid5t ,bevan t !re %\ld be clos] coop]ation betwe5 ! l>ge ph>maceutical h\ses & ! ,c\ncil on ,ph>macy & ,*emi/ry1 ! ,c\ncil submitt$ to ! ,bo>d ( ,tru/ees ( ! ,am]ican ,m$ical ,association ! /atem5t :i* appe>s bel[3 8,,coop]ation ,,( ,,! ,,ph>maceutical ,,h\ses3 ,at ! op5+ meet+ ( ! ,h\se ( ,delegates la/ ye>1 ,presid5t ,ar?ur ,dean ,bevan sugge/$ ! desirability ( great] coop]ation betwe5 ! l>ge ph>maceutical h\ses & ! ,c\ncil on ,ph>macy & ,*emi/ry4 ,! ne$ ( su* coop]ation has be5 recogniz$ by ! ,c\ncil f ! fir/4 ,9 no "o direction has ! ,c\ncil made great] ef=t ?an 9 its endeavor to secure ! fulle/ coop]ation ( ! v>i\s ph>maceutical h\ses4 ,! difficulty has be51 & always mu/ be1 ! fundam5tal antagonism betwe5 objectives t are l>gely comm]cial on ! "o h& & purely sci5tific on ! o!r4 ,nev]!less1 ! ,c\ncil has always believ$--& has act$ on ! belief--t !re is a possible middle gr\nd :]e9 ! int]e/s ( !rapeutics w\ld n be injur$ b w\ld g h& 9 h& ) a comm]cial developm5t bas$ on enlight5$ self-int]e/4 8,! pr(its to be made by a ph>maceutical h\se f ! sale ( a /aple drug--a ph>macopeial1 ,national ,=mul>y1 or nonpropriet>y prep>ation--:i* ent]s into free competition ) o!r drugs ( ! same k9d1 are mod]ate2 ! pr(its to be made f ! sale ( a propriet>y m$ic9e on :i* ! manufactur] holds a monopoly are usually l>ge--sometimes enorm\s4 ,!re are1 broadly1 two k9ds ( propriet>y prep>ations adv]tis$ to physicians3 ,"o repres5ts labori\s rese>* end+ 9 ! production ( a new m$ic9al *emical2 ?is product c be pat5t$ & ! manufactur] c obta9 a sev5te5-ye> monopoly on its manufacture & sale4 ,! o!r repres5ts no rese>* b comprises simple mixtures--frequ5tly ( ! 8%otgun0 v>iety--( well kn[n ph>maceuticals1 or biologic products sold "u trade names4 ,z ^! d n repres5t any?+ new or orig9al ! manufactur] is unable to obta9 a pat5t1 b by means ( ! trade "n he c & does obta9 a p]petual monopoly4 ,?is1 f a bus9ess /&po9t1 is m valuable ?an ! limit$ monopoly grant$ by a pat5t4 ,x is n surpris+ t propriet>y rem$ies ( ! latt] type fl\ri% s long z physicians un?9k+ly accept & prescribe !m solely on ! manufactur]'s valuation4 8,! ,c\ncil has practically ! undivid$ support ( manufactur]s ( m$ic9al *emicals2 t is1 ( propriet>ies ( ! fir/ m5tion$ type4 ,b ph>maceutical firms :i* h f\nd x pr(itable to promote propriet>ies ( ! second type--8specialties10 unsci5tific or ord9>y mixtures ( ph>maceuticals or biologic products sold "u trade names--h n support$ ! ,c\ncil4 8,:5 ! ,c\ncil 0 organiz$1 x 0 hop$ & believ$ t all ! l>ge ph>maceutical h\ses w\ld f9d x possible & desirable1 if n actually m pr(itable1 to %ape _! bus9ess me?ods s z to make _! propriet>y & o!r articles con=m to ^? cons]vative /&>ds on :i* ! ,c\ncil bases its rules1 & ?us r5d] su* articles acceptable = ,new & ,non(ficial ,rem$ies4 ,x soon develop$1 h[ev]1 t ! me?ods ( ! pseudo*emical companies1 ^: sales propag&a 9 ! int]e/ ( unsci5tific no/rums ) its att5d+ damage to sci5tific m$ic9e _h l$ to ! e/abli%m5t ( ! ,c\ncil1 _h f\nd _! lodgm5t 9 mo/ ( ! ph>maceutical h\ses4 ,x 0 a g5u9e disappo9tm5t to ! ,c\ncil to f9d t "s ( ! l>ge & old-e/abli%$ firms 7 n only unwill+ to coop]ate ) ! ,c\ncil1 b 9 _m in/ances exhibit$ a def9ite antagonism to ! ,c\ncil's "w4 8,! object--& duty--( ! (fic]s ( ph>maceutical h\ses is prim>ily to pay divid5ds to _! /ockhold]s4 ,?r\gh skilful adv]tis+ or ! p]suasiv5ess ( 8detail m510 !y are able to induce physicians to prescribe _! controll$ products1 on :i* !re are l>ge pr(its1 ev5 ?\gh su* products h n only n be5 accept$ by ! ,c\ncil1 b 9 _m in/ances1 h be5 disapprov$4 ,is x any wond] t conc]ns :i* put out su* products are indiff]5t or op5ly antagoni/ic to ! "w ( ! ,c\ncil8 ,! matt] is l>gely "o ( bus9ess policy4 ,:5 ! m$ical pr(ession z a unit w support ! ,c\ncil 9 its "w1 !n su* firms w f9d x good bus9ess policy to acc$e to ,dr4 ,bevan's sugge/ion--b n be=e40 ,evid5tly ! problem resolves itself into ?is3 ,! ,c\ncil1 con/itut$ ( sci5tific m51 work+ )\t remun]ation 9 ! int]e/ ( sci5tific m$ic9e & ! m$ical pr(ession1 expects--& rightfully--! coop]ation & support ( ! memb]s ( t pr(ession4 ,:at is ne$$1 !re=e1 is ! active1 sympa!tic coop]ation ( physicians2 ! coop]ation ( ph>maceutical h\ses w foll[ z a matt] ( c\rse4 7,j4 ,a4 ,m4 ,a4 #gd3abce ,may #a #aibj47 ,! foll[+ is ! recomm5dation ( ! ,ref]5ce ,committee to :i* ! ,report ( ! ,bo>d ( ,tru/ees 0 ref]r$3 8,a p]usal ( ! ,tru/ees' ,report1 #8,coop]ation ( ! ,ph>maceutical ,h\ses'1 is well wor? ! "t ( e memb] ( ! pr(ession1 & y\r committee w\ld emphasize ! /atem5t ( ! ,tru/ees3 #8,! ,c\ncil1 con/itut$ ( sci5tific m51 work+ )\t remun]ation 9 ! int]e/ ( sci5tific m$ic9e & ! m$ical pr(ession expects--& rightfully--! coop]ation & support ( ! memb]s ( t pr(ession4 ,:at is ne$$1 !re=e1 is ! active sympa!tic coop]ation ( physicians2 ! coop]ation ( ph>maceutical h\ses w foll[ z a matt] ( c\rse4' 8,y\r committee w\ld g /ill fur!r & move t a vote ( ?anks ( ! ,h\se be ext5d$ to ^? sci5tific m5 :o h devot$ s mu* valuable "t to ! welf>e ( ! ,association40 7,j4 ,a4 ,m4 ,a41 #gd3acbb ,may #h #aibj2 f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aibj1 p4 #ef74 ,w4 ,a4 ,puckn]1 ,secret>y4 ,,budwell',s ,,emulsion ,,( ,,cod-,,liv] ,,oil1 ,,nos4 #a ,,& #b ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,budwell ,ph>macal ,company1 ,lyn*burg1 ,virg9ia1 :i* m>kets ^! prep>ations1 claims t 8,no4 #a0 conta9s cod liv] oil1 8,iodide ( ,ars5ic10 8,iodide ( ,calcium10 & 8,iodide ( ,manganese40 8,no4 #b0 is said to conta9 9 addition to ! +r$i5ts ( ,no4 #a1 creosote c>bonate & guaiacol4 ,x is kn[n t ars5\s iodid is decompos$ by contact ) wat]4 ,x is recogniz$ t creosote c>bonate is un/able & prone to lib]ate creosote4 ,iodide ( manganese n be+ (ficial1 ! supply on ! m>ket is n controll$ 9 any way3 ,te/s ( purity are n prescrib$ by ! ,ph>macopeia1 ! ,national ,=mul>y1 ,new & ,non(ficial ,rem$ies or o!r books ( /&>ds4 ,!re=e d\bt mu/ be express$ z to ! accuracy ( ! =mulas z giv54 ,! ,c\ncil _c accept su* /atem5ts ( composition )\t fur!r evid5ce4 8,no4 #a0 is comm5d$ = use 9 8,*ronic ,rheumatism1 ,gl&ul> ,swell+s1 lat] =ms ( ,syphilis1 convalesc5ce f ,sc>let ,fev]1 ,la ,grippe & ,mal>ia1 ,*ronic ,mal>ial ,infection1 ,m>asmus1 ,jo9t or o!r suppuration ( /&+1 diseases ( sk91 *orea1 anaemia1 neura/h5ia1 ob/9ate neuralgia1 scr(ul\s affections 9 g5]al1 & di>rhea or dys5t]y 7subacute or *ronic7 9 *ildhood40 8,no4 #b0 is said to be 8,prep>$ especially = ! treatm5t ( ,*ronic ,?roat1 ,nasal1 ,bron*ial & ,pulmon>y ,diseases40 ,9 ! adv]tis+ circul> /atem5ts reg>d+ ! v>i\s +r$i5ts ( ,budwell's ,emulsion are quot$ f obsolete text books4 ,^! /atem5ts1 = ! mo/ "p1 d n repres5t mod]n op9ions on ! subject4 ,= in/ance1 ! circul> praises ! action ( guaiacol z elim9at$ directly by ! lungs1 ?us ex]t+ a b5eficial local effect & caus+ bacilli to dim9i% 9 numb]s or to disappe>4 ,all ( ?is is directly contradict$ 9 au?oritative mod]n publications on ph>macology1 :i* hold t ! excretion ( guaiacol by ! lungs is inf9itesimal & its action on bacilli is nil4 ,! ,c\ncil held ! prep>ations 9 conflict ) its rules z foll[s3 #a4 ,_m ( ! !rapeutic claims are exagg]ations4 #b4 ,! me?od ( exploitation am\nts to an indirect invitation to ! public to use ^! prep>ations z 8consumption cures40 #c4 ,! prep>ations are unsci5tific1 !y con/itute a repreh5sible invitation to uncritical prescrib+ & _! use is inimical to ! be/ int]e/s ( ! pr(ession & ! public4 ,x is difficult to imag9e 9 :at conditions su* a comb9ation w\ld be indicat$4 ,^! prep>ations are a remnant ( ! days ( polyph>macy4 ,_! use is n 9 keep+ ) pres5t m$ical ?\ght & practice4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,feb4 #bj1 #aiae47 ,,rheumalg9e ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,rheumalg9e 7,eli ,lilly ,co41 ,indianapolis7 is put up bo? 9 tablet =m & z a liquid4 ,ea* tablet1 or teaspoonful ( ! liquid1 is said to conta93 8,/rontium salicylate f ,natural ,oil #e gr4 ,hexame?yl5am9 #b gr4 ,col*ic9e #a_/bjj gr40 ,! adv]tis+ matt] conta9s sev]al /atem5ts reg>d+ ! individual +r$i5ts to :i* objection mu/ be made4 ,x is claim$ 7quot+ f ,h>e7 t /rontium salicylate 8444 is n s disagreeable to ! ta/e z ! correspond+ sodium salts1 & m important /ill1 x is f> less apt to disord] ! /oma*40 8,ta/e0 is a difficult subject to dispute2 b 9 ! exp]i5ce ( ! ref]ee1 pati5ts object m to ! /rontium ?an to ! sodium salt4 ,no evid5ce is submitt$ to prove t ! /rontium salt is less apt to disord] ! /oma*4 ,9 obs]vations made "u ! direction ( ! ref]ee1 ! nauseant & emetic doses are ab\t ! same z1 or ev5 less ?an1 ^? ( sodium salicylate4 ,"u hexame?yl5am91 ! recomm5dations are n conf9$ to its recogniz$ use z a ur9>y antiseptic2 x is also said to be 8unexcell$0 z a 8g]micide10 & to prev5t ! =mation ( urate & phosphate deposits4 ,^! /atem5ts are contr>y to facts4 8,rheumalg9e 444 may be us$ 9 all cases :]e ! salicylates are indicat$4 ,x is sup]ior to prep>ations conta9+ sodium salicylate1 9 t x does n cause nausea or di/urb ! dige/ion40 ,bo? ! prec$+ /atem5ts are mislead+4 ,! necessity ( giv+ #a_/bjj gra9 ( col*ic9 = ea* #e gra9s ( salicylate w\ld c]ta9ly int]f]e ) ! use ( adequate doses ( ! latt]4 ,! col*ic9 w\ld produce dige/ive di/urbance q ap>t f ! salicylate4 ,! mixture is describ$ z3 8444 ,,antirheumatic1 ,,antipyretic1 ,,ur9>y ,,antiseptic1 ,,& ,,uric ,,acid ,,elim9ant4 ,useful 9 ,acute ,articul> & ,*ronic ,rheumatism1 ,muscul> ,pa9s1 ,lumbago1 ,sciatica1 ,migra9e ( ! ,rheumatic1 ,g\t1 & 9 ,n]v\s ,irritability ( ! ,g\ty or ,li!mic40 ,! facts are3 ,salicylates are useful 9 "s ( ^! conditions1 col*ic9 occasionally 9 a few1 hexame?yl5am9 9 none4 ,! comb9ation is conducive to uncritical prescrib+4 ,= in/ance1 salicylates are effective 9 acute articul> rheumatism2 hexame?yl5am9 & col*ic9 are useless2 salicylates are ( v little use 9 *ronic rheumatism1 sciatica & n]v\s irritability1 :ile hexame?yl5am9 & col*ic9 are useless 9 ^! conditions2 col*ic9 is sometimes effective 9 g\t1 salicylates p]haps also2 hexame?yl5am9 is n4 ,att5tion %\ld also be call$ to ! high dosage ( col*ic91 namely1 #a_/ajj to #a_/ej ( a gra9 ( ! alkaloid1 e ?ree or f\r h\rs1 ! dose !n to be 8slightly r$uc$10 b cont9u$ = sev]al days2 or 9 *ronic cases1 #a_/ajj to #a_/cj gra9 p] day1 cont9u$ indef9itely4 ,?is dosage appe>s high1 if a really active prep>ation is us$4 ,f9ally1 ! "n 8,rheumalg9e0 enc\rages ?\ghtless & unsci5tific prescrib+4 ,if a mixture is us$ at all1 ! prescrib] %\ld be con/antly rem9d$ ( its composition4 ,x is !re=e recomm5d$ t ,rheumalg9e be held 9 conflict ) ,rules #f 7unw>rant$ !rapeutic claims71 #h 7nondescriptive "n7 & #aj 7unsci5tific composition74--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,june #bf1 #aiae47 ,,gray',s ,,glyc]9e ,,tonic ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil adopt$ ! foll[+ report & au?oriz$ its publication4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,gray's ,glyc]9e ,tonic ,comp4 7,purdue ,fr$]ick ,company1 ,new ,york7 is a mixture said to be made accord+ to a prescription ( ! late ,dr4 ,john ,p4 ,gray1 sup]9t5d5t ( ! /ate hospital1 ,utica1 ,new ,york4 ,z to ! composition1 ! foll[+ /atem5t is furni%$ by ! company3 8,?is prep>ation is a comb9ation ( ,glyc]9e1 ,%]ry ,w9e1 ,g5tian1 ,t>axacum & ,phosphoric ,acid ) c>m9atives40 ,! label decl>es ! pres5ce ( #aa p] c5t4 alcohol1 & ! dose is giv5 at f two teaspoonfuls to a tablespoonful4 ,a /udy ( ! +r$i5ts w %[ t1 aside f ! alcohol1 ! mixture conta9s b "o really active drug1 g5tian4 ,ess5tially1 !n1 8,gray's ,glyc]9e ,tonic0 is a mixture :i*1 9 addition to ! n>cotic effect ( ! alcohol1 dep5ds on a bitt]1 g5tian1 = :atev] !rapeutic action x may possess4 ,! bitt]s1 ( :i* g5tian is a type1 7 once cr$it$ ) _m !rapeutic virtues :i* "t has %[n !y d n possess4 ,ph>macologic rese>* has demon/rat$ t _! utility consi/s 9 /imulat+ ! appetite ?r\gh _! action on ! ta/e buds4 ,on ?is acc\nt !y 7 believ$ also to increase ! secretion ( ! ga/ric juice by a psy*ic impression4 ,m rec5tly1 h[ev]1 ev5 ?is has be5 que/ion$--by ,c>lson1 = in/ance4 ,^! facts are fully und]/ood1 presumably1 by all physicians4 ,yet1 accord+ to ! adv]tis+ circul>1 ?is 8tonic10 :i*1 = all practical purposes1 is m]ely a simple bitt]1 is good = ?irty-two diseases rang+ f am5orrhea to :oop+ c\gh6 ,! conditions 9 :i* ,gray's ,glyc]9e ,tonic is ass]t$ to be especially effici5t are describ$ on ! label ( ! bottle & ! outside wrapp]1 9 popul> t]ms1 m or less typical ( 8pat5t m$ic9e0 exploitation1 su* z 8cat>rhal conditions10 & 8/oma* d]angem5ts40 ,simil> /atem5ts are conta9$ 9 ! leaflet accompany+ ! trade package4 ,= in/ance3 8,x is1 !re=e1 an effective1 reliable tonic 9 n]v\s exhau/ion1 g5]al debility1 impov]i%$ conditions ( ! blood & n]v\s sy/em1 ,bright's disease1 diseases ( ! liv]1 disord]s ( ! ur9>y organs1 etc40 8,x is an unexcell$ re/orative 9 t v common class ( cases 9 :i* !re is no positive organic disease1 b ! pati5t compla9s t he #8does n feel well' or #8is out ( sorts4'0 ,"h are "s ( ! claims made 9 o!r adv]tis+ matt]3 8,all /ages ( bron*itis 444 are rapidly improv$ by ! use ( ,gray's ,glyc]9e ,tonic ,comp4 ,?is rem$y has a direct tonic influ5ce ^u ! circulation ( ! respiratory muc\s membrane2 x relieves conge/ion & re/ores tone to weak5$ blood vessels40 8444 improves ! appetite1 gives valuable aid to ! dige/ive & absorptive processes1 & re9=ces cellul> nutrition 9 ways t insure a notable ga9 9 vitality & /r5g?40 ---------------------------------------- ------------------------- ,9 ,ga/ro-,inte/9al ,cat>rh --& o!r afflictions ( ! /oma* & b[els *>act]iz$ by muscul> weakness & gl&ul> insuffici5cy--!re is no rem$y m prompt & effective 9 its action ?an ,gray's ,glyc]9e ,tonic ,comp4 ,"u its sy/ematic adm9i/ration ! appetite is re/or$1 ! alim5t>y processes greatly improv$1 ! nutrition promot$ & e vital function ?r\gh\t ! body giv5 a new & sub/antial impetus4 ,z ! dige/ive & assimilative functions are re/or$ to _! normal effici5cy1 a notable increase 9 ! re/orative & recup]ative p[]s ( ! body naturally foll[4 ,,! ,,purdue ,,fr$]ick ,,co4 #ace ,*ri/oph] ,/reet1 ,new ,york ,city ---------------------------------------- ------------------------- ,m5tion ,,ill9ois ,,m$ical ,,j\rnal :5 writ+ to adv]tis]s4 ,illu/ration3 ,?is appe>$ 9 a j\rnal own$ & controll$ by ! second l>ge/ /ate m$ical association ( ! c\ntry4 ,ev5 grant+ t g5tian may improve ! appetite1 h[ absurd x is to claim t ?is mixture 8relieves conge/ion10 8re/ores tone to weak5$ blood vessels10 8gives aid to ! absorptive processes10 8re9=ces cellul> nutrition10 or increases vitality6 ,nei!r ! composition ( ,gray's ,glyc]9e ,tonic nor ! cl9ical evid5ce w>rants ! belief t x has any !rapeutic value o!r ?an t due to ! psy*ic effect ( ! bitt] drug g5tian4 ,physicians :o h prescrib$ x h done s because ( ! adv]tis+4 ,?is no/rum has be5 kept s con/antly be=e ! eyes ( m$ical m5 t !y ?9k ( ,gray's ,glyc]9e ,tonic :5 !y _c rememb] ! (ficial drugs t may be indicat$ 9 ! case4 ,! moral is t lib]al adv]tis+ w sell any?+4 ,x is recomm5d$ t ,gray's ,glyc]9e ,tonic ,comp4 be decl>$ n eligible = inclusion 9 ,new & ,non(ficial ,rem$ies on acc\nt ( conflict ) ,rules #a1 #f1 #h & #aj4 ,editorial ,note4--,an old practice 9 hospitals--happily n[ practically obsolete--0 to h c]ta9 /ock mixtures prep>$ 9 bulk4 ,among ^! !re 0 usually a s-call$ tonic mixture1 us$ 9 a m or less haphaz>d mann] :5 no?+ 9 p>ticul> seem$ indicat$4 ,su* a /ock mixture 0 us$ 9 ! ,/ate ,hospital = ! ,insane at ,utica1 ,n4 ,y41 dur+ ! _m ye>s t ,dr4 ,john ,p4 ,gray 0 sup]9t5d5t 7f ! e>ly fifties to ! e>ly eighties71 al?\gh x is v d\btful :e!r he orig9at$ ! mixture4 ,aft] ! dea? ( ,dr4 ,gray--s ! /ory runs--"o ( 8 sons1 ) a p>tn]1 =m$ ! firm ( ,purdue ,fr$]ick ,company1 & began ! exploitation ( ! eld] ,dr4 ,gray's "n1 9 connection1 presumably1 ) ?is /ock prep>ation4 ,z indicat$ 9 ! ,c\ncil's report1 ,gray's ,glyc]9e ,tonic ,comp4--& :at an absurd "n6--is simply a mixture ( ord9>y drugs1 requir+ no skill :atev] 9 comp\nd+4 ,if !re is a physician liv+ :o _c write a prescription (fh& z good z ?is =mula1 t physician %\ld ei!r g back to a m$ical s*ool or *ange 8 vocation4 ,!re is1 & c be1 no excuse = prescrib+ su* a ready-made mixture1 = e cross-roads drug/ore has ! +r$i5ts & any ph>maci/ wor?y ( ! "n c\ld comp\nd x4 ,among ! scores ( no/rums t disgrace ! m$ical pr(ession ( ?is c\ntry1 none is m typical ( all t is inimical to sci5tific m$ic9e1 to ! m$ical pr(ession & above all to ! public--=1 aft] all is said1 x is ! public t ultimately is humbugg$4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,july #aj1 #aiae47 ,,tongal9e ,,& ,,ponca ,,comp\nd ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil1 hav+ consid]$ 8,tongal9e10 8,tongal9e ,tablets10 8,tongal9e & ,li?ia ,tablets10 8,tongal9e & ,qu99e ,tablets0 & 8,ponca ,comp\nd ,tablets10 f\nd ^! prep>ations ineligible = ,new & ,non(ficial ,rem$ies & au?oriz$ publication ( ! foll[+ report4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,,tongal9e ,tongal9e 7,melli] ,drug ,co41 ,/4 ,l\is7 is a fancy "n giv5 to :at is ess5tially a sodium salicylate mixture4 ,! air ( my/]y creat$ by ! "n p]mits ! manufactur]s to make claims = ! product :i* w\ld be ludicr\s if ! m$ical pr(ession 0 fully conv]sant ) ! v ord9>y "* ( ! prep>ation4 ,tongal9e receives its "n f tonga1 an in]t1 long-disc>d$ mixture ( v>i\s b>ks & h]bs said to be ga!r$ & prep>$ by ,fiji ,isl&]s4 ,its con/itu5ts evid5tly t5d to v>y ) ! collector4 ,! hi/ory ( ! introduction ( ?is indef9ite comb9ation ( simples is ?us giv5 9 ,! ,j\rnal1 ,may #aj1 #aiac4 8,a supply ( ! crude drug 0 c>ri$ to ,engl& by a man :o _h liv$ = a %ort "t 9 ! ,fiji ,isl&s & x 0 plac$ 9 ! h&s ( a retail h\se 9 ,london4 ,?is occurr$ ab\t #ahgi4 ,9 #ahhj1 two ,engli% physicians ( repute publi%$ laudatory articles on ! !rapeutic value ( tonga 9 neuralgia & rheumatism4 ,?is creat$ a dem& = ! drug :i* ext5d$ to ! ,unit$ ,/ates40 ,"t %[$ t tonga 0 in]t !rapeutically1 & au?orities on ph>macology n[ no long] notice x4 ,z ! ,c\ncil previ\sly report$1#ab ! indef9ite "* ( ! mixture %\ld1 alone1 be suffici5t to exclude x f practical !rapeutics4 ,dur+ ! tempor>y popul>ity ( tonga1 ! propriet>y mixture ,tongal9e 0 put on ! m>ket = physicians' use by ! ,melli] ,drug ,company1 ,/4 ,l\is4 ,9 ?is1 tonga 0 nam$ z ! active +r$i5t4 ,! comm]cial int]e/s ?us involv$ h fai?fully n\ri%$ & kept alive ! 8tonga0 my?4 #ab ,reports ( ! ,c\ncil on ,ph>m4 & ,*em41 #aiab1 p4 #dj4 ,9 a rec5t adv]tis+ booklet1 8,! ,!rapeutic ,prop]ties ( ! ,+r$i5ts ( ,tongal9e10 ! virtues ( tonga1 blue coho%1 col*icum1 jabor&i & salicylic acid are discuss$4 ,! label ( a rec5tly pur*as$ bottle reads3 8,tongal9e conta9s ,tonga1 ,cimicifuga ,racemosa1 ,salicylate ( ,sodium 7! salicylic acid be+ made f pure natural oil7 ,col*icum & ,piloc>p940 ,x w be notic$ t ,tongal9e is 8made f ! pure1 natural oil40 ,9 fact1 ! /atem5t is repeat$ 9 r$ ink1 9 l>ge lett]s runn+ across ! face ( ! label1 ?us emphasiz+ ! alleg$ importance ( ?is ass]tion4 ,9 ?is connection x is only necess>y to recall t x has be5 prov$ cl9ically1 *emically & physiologically t !re is absolutely no diff]5ce betwe5 ! salicylic acid made f ! natural oil & ! syn!tic4 ,! =mula 0 ?us comm5t$ on 9 ! article previ\sly quot$ f ,! ,j\rnal3 8,tongal9e 444 is ess5tially a prep>ation ( sodium salicylate1444 ,! ,melli] ,drug ,company realiz$ ! impossibility ( creat+ any m>k$ dem& = a no/rum unless x _h "s real drugs 9 x--h5ce ! pres5ce ( ! salicylates4 ,:at ! actual composition ( ,tongal9e is1 no "o b ! manufactur]s "k4 ,at "o "t ! foll[+ 0 giv5 z ! =mula3 ,fluid ,tonga #cj gra9s ,extract ( ,cimicifuga ,racemosa #bj gra9s ,sodium ,salicylate #aj gra9s ,piloc>p9 ,salicylate #a_/ajj gra9 ,col*9 ,salicylate #a_/ejj gra9 8,^! am\nts ref] to ! quantity ( drugs 9 ea* fluidram ( ! prep>ation4 ,:e!r ! no/rum /ill has ?is composition we d n "k1 b assum+ t x has1 x is q evid5t t sodium salicylate is ! ess5tial & active +r$i5t40 ,! !rapeutic indications giv5 on ! label ( ! bottle are3 8,rheumatism1 ,neuralgia1 ,grippe1 ,g\t1 ,n]v\s ,heada*e1 ,sciatica1 ,lumbago1 ,mal>ia1 ,tonsillitis1 ,heavy ,colds1 ,excess ( ,uric ,acid1 & :]ev] ! use ( ! ,salicylates is indicat$40 ,9 a rec5t booklet ?is semisecret salicylate mixture is recomm5d$1 n only 9 conditions 9 :i* salicylates are indicat$1 b also comb9$ ) aconite = rheumatic fev]1 ) b5zoate ( soda 9 ! treatm5t ( 8grippe10 ) potassium bromid 9 n]v\s heada*es1 ) gelsemium1 glyc]9 & :isky = 8heavy colds10 ) ammonium *lorid1 /ramonium & cimicifuga 9 8rheumatic dysm5orrhea10 & ev5 ) m]cury b9iodid z a treatm5t ( syphilitic eruptions6 8,:5 adm9i/]$ ) good judgm5t1 ,tongal9e ex]ts a /imulat+ effect ^u e organ ( elim9ation2 cleans+ ! complex sew]age sy/em & putt+ x into work+ ord]4 ,:5 ?is is done1 ! sluggi% blood curr5t beg9s to fl[ m freely2 ! lymphatic & gl&ul> sy/ems to give up & c>ry (f ! toxic products1 s long reta9$ 4440 ,,tongal9e ,,tablets ,!n because ( a 8desire to put ,tongal9e 9 a m compact & conv5i5t =m10 ! same conc]n puts on ! m>ket ,tongal9e ,tablets4 ,:e!r ,tongal9e ,tablets are ( ! same composition1 ! doctor :o prescribes !m is n advis$4 ,9 ?is =m we h ,tongal9e & ,li?ia ,tablets1 & ,tongal9e & ,qu99 ,tablets4 ,presumably ^? :o are attract$ by ! ^w 8li?ia0 are suffici5tly uncritical to be cont5t ) ! /atem5t t3 8,! addition ( ,li?ia to ,tongal9e pres5ts a mo/ useful comb9ation :i* does n rely ^u its action on ! kidneys alone z is ! case ) ,li?ia salts or ,li?ia wat]s z adm9i/]$ 4440 ,& ! =ego+ quotation1 be x rememb]$1 is = ! in=mation ( ! m$ical pr(ession6 ,tongal9e & ,li?ia ,tablets1 we are in=m$1 are3 8444 p>ticul>ly indicat$ = c]ta9 diseases :i* are caus$ by deposits ( urates 9 ! jo9ts & kidneys1 & c be us$ ) mu* b5efit = _m p :o indulge 9 g5]\s or intemp]ate habits ( liv+40 ,tongal9e & ,qu99e ,tablets are also exploit$ )\t /atem5t ( composition4 ,! promot]s are probably ju/ifi$ 9 feel+ t physicians :o prescribe qu99 9 comb9ation ) 8,tongal9e0 c>e little ab\t ! dosage4 ,x is unnecess>y to discuss ! silly claims made = ,tongal9e & its comb9ations1 al?\gh x is wor? :ile to po9t out t ! prescrib+ ( su* no/rums by physicians is an imposition1 if n a fraud1 on ! public4 ,,ponca ,,comp\nd ,ponca ,comp\nd1 also made by ! ,melli] ,drug ,company1 ,/4 ,l\is1 is a 8female weakness rem$y0 9 tablet =m4 ,! "n sugge/s t 8ponca0 is a m$ic9al sub/ance1 &1 9 fact1 at "o "t1 8,ext4 ,ponca0 0 nam$ z an +r$i5t4 ,! nature ( 8,ext4 ,ponca0 0 app>5tly nev] expla9$4 ,x is n[ replac$ 9 ! 8=mula0 by 8s5ec910 & ! only in=mation conc]n+ ! composition at pres5t giv5 is3 8,ponca ,comp\nd ,tablets ,conta9 ,extract ( ,mit*ella ,rep5s1 ,s5ec91 ,helon91 ,caulophyll9 & ,viburn940 ,?is 8=mula0 is practically mean+less1 n only because ! am\nt ( ea* +r$i5t is n /at$1 b also because 8s5ec910 8helon910 8caulophyll90 & 8viburn90 are 9 !mselves v>iable mixtures ( unkn[n composition4#ac #ac ,see ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry on 8,res9oids & ,conc5trations10 ,j4 ,a4 ,m4 ,a41 ,nov4 #ac1 #aiji1 p4 #afee4 ,presumably1 8s5ec910 8helon910 8caulophyll90 & 8viburn90 are extractives ( "s k9d prep>$1 respectively1 f s5ecio aureus 7life root71 helonias dioica 7false unicorn71 calophyllum ?alictroides 7blue coho%7 & viburnum prunifolium or opulus 7black haw or cramp b>k74 ,^! are1 "o & all1 practically in]t drugs4 ,!re is no reason to believe t any or all ( !m c h any b5eficial influ5ce 9 ! _m & v>i$ conditions = :i* ,ponca ,comp\nd is adv]tis$4 ,! foll[+ are exc]pts f ! adv]tis+ matt]3 8,ponca ,comp\nd is a rem$y ( a v b5eficial "* = ,functional1 ,ut]9e & ,ov>ian tr\bles1 :i* w respond to int]nal treatm5t1 especially :5 digital exam9ation or surgical int]f]5ce is undesirable40 8,ponca ,comp\nd is also valuable dur+ ge/ation & aft] p>turition40 8,ut]9e ,alt]ative = ,leucorrhoea1 ,dysm5orrhoea1 ,am5orrhoea1 ,metritis1 ,endometritis1 ,m5orrhagia1 ,metrorrhagia1 ,irregul> ,m5/ruation1 ,sub9volution1 ,pa9ful ,pregnancy40 ,x is recomm5d$ t ,tongal9e & ,ponca ,comp\nd & all _! prep>ations be held 9 conflict ) ,rule #a1 9 view ( _! semisecret & indef9ite composition2 ) ,rule #f1 = ! grossly exagg]at$ !rapeutic claims made = !m2 ) ,rule #h1 because ( _! mislead+ names1 & ) ,rule #aj1 9 view ( _! unsci5tific "* z irrational comb9ations4 ,x is also recomm5d$ t ?is report be publi%$4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,july #ag1 #aiae47 ,,alfatone ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has f\nd ,alfatone ineligible = ,new & ,non(ficial ,rem$ies & has au?oriz$ publication ( ! foll[+ report4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,alfalfa is good cattle fe$ b only no/rum exploit]s h sugge/$ its use z a m$ic9e = human be+s4 ,:ile x may seem a wa/e ( "t to discuss ! m$ic9al value ( alfalfa its rec5t exploitation by ! ,norwi* ,ph>macal ,company1 ,norwi*1 ,n4 ,y41 z 8a recon/ructive tonic & nutri5t0 9 ! =m ( a mixture call$ 8,alfatone10 calls = comm5t4 ,accord+ to ! label on ! prep>ation3 8,ea* fluid\nce repres5ts3 ,alcohol #ae p] c5t4 ,m$icago sativa 7,alfalfa7 #abj gra9s ,t>axacum #b-a_/b gra9s ,g5tian #a gra9 ,b]b]9e ,hydro*loride #a_/dj gra9 ,glyc]9 & ,aromatics40 8,dose4--,"o to ?ree fluidrams 7#d to #ab c4c47 #d times daily40 ,ea* maximum dose1 !re=e1 %\ld repres5t #de gra9s ( alfalfa1 #a gra9 ( t>axacum 7d&elion71 #c_/h gra9 ( g5tian1 #a_/ajj gra9 ( b]b]9 hydro*lorid1 & #bg m9ims ( alcohol4 ,s9ce ! bitt] drugs are pres5t 9 su* small am\nts t ! prep>ation is almo/ devoid ( bitt]ness1 & z ! m$ic9al value ( alfalfa is practically nil1 x is evid5t t :atev] action ,alfatone may h is due to ! /imulant effects ( ! alcohol4 ,"s ( ! claims made = ,alfatone are3 8,a recon/ructive nutritive tonic indicat$ 9 g5]al debility1 neura/h5ia1 convalesc5ce1 etc40 8444 a ,galactagogue ( m]it z well40 8444 improves ! appetite1 aids ! processes ( dige/ion & assimilation1 facilitates elim9ation & effects gradual b decid$ ga9s 9 /r5g?1 vitality & weight40 ,x is sugge/$ t3 8444 9 case ( idiosyncrasy ! addition ( ,tr4 ,nux ,vomica #e to #aj m9ims to ! dose1 unless contra9dicat$1 w secure excell5t results40 ,! ,norwi* ,ph>macal ,company naively rem>ks3 8,! de>? ( m$ical lit]ature on ,alfalfa has lead u to pres5t bel[ a few ( ! f9d+s ( ! ,bureau ( ,plant ,indu/ry ( ! ,dep>tm5t ( ,agriculture 444 z well z ^? f sev]al /ate exp]im5t /ations 4440 ,"h are ! 8f9d+s03 8444 ,dige/ible nutri5ts 9 #ajj p\nds ( ,alfalfa1444 ,prote91 #aa4j p\nds2 ,c>bohydrates1 #ci4f p\nds2 ,e!r ,extract1 #a4b p\nds40 8444 ,! high value ( ,alfalfa is due to ! am\nt ( prote9 t x conta9s2 to ! l>ge p]c5tage ( prote9 t is dige/ible & ! palatability ( ,alfalfa40 8444 ,table %[+ p\nds ( elem5ts remov$ f ! soil by "o ton ( crop4 ,alfalfa ,:eat ,pota% #di4gi #ab4eb ,phosphoric ,acid #h4bg #i4jh ,lime #dc4ea #b4ie ,nitrog5 #dd4ja #bb4cj0 8444 ,! abundance ( muscle & bone produc+ mat]ial 9 ,alfalfa makes ?is crop especially good40 ,?us e/imates ( ! value ( a f>m crop & cattle fodd] are made to d s]vice z te/imonials to its !rapeutic m]it = human be+s6 ,has ! 8pat5t m$ic9e0 promot] ev] d>$ to insult ! intellig5ce ( 8 patrons by a crud] absurdity8 ,yet x is n to ! nonte*nical & unsci5tific public1 b to a pr(ession presumably sci5tifically tra9$ 9 ph>macology & !rapeutics t ?is conc]n presumes to (f] its fodd] t9cture on ! basis ( te/imony to ! agricultural value ( ! fodd] plant4 ,alfatone is a wor?less alcoholic cordial4 ,! audacity ( ! attempt to promote its sale by a disc\rse on ! m]its ( a well-kn[n fodd] plant is ! sole reason = devot+ any att5tion to x4 ,x is recomm5d$ t ,alfatone be held ineligible = ,new & ,non(ficial ,rem$ies1 & t ?is report be publi%$4 ,editorial ,note4--,:at a comm5t on ,am]ican m$ic9e t a conc]n c ev5 contemplate ! possibility ( mak+ a comm]cial success ( ! sale ( su* a silly no/rum z ,alfatone6 ,& yet1 :5 "o rememb]s t a propriet>y 9 :i* oats con/itutes "o +r$i5t 78,pas-,av5a07 = ye>s has be5 adv]tis$ to physicians & presumably prescrib$ by !m1 x is n altoge!r inexplicable t bus9ess m5 %\ld get ! impression t ! m$ical pr(ession is 8easy0 en\gh to 8fall =0 any?+ 9 ! l9e ( propriet>y mixtures4 ,p]haps we may look =w>d to be+ (f]$ propriet>ies bas$ on o!r *eap & well-kn[n fodd] plants4 ,t9cture ( ,timo?y ,hay1 ,blue ,grass ,tonic1 ,cornhusk ,w9e6 ,:y n8 ,! ent]pris+ companies t may put !m out c easily publi% tables to %[ ! dige/ible nutri5ts 9 ea* & indubitable te/imony c be furni%$ to prove ! excell5ce ( any ( !m z /ock fe$4 ,if a pit*=kful ( timo?y hay makes a good fatt5+ ration = a gr[+ /e] :y %\ld n a teaspoonful ( t9cture ( timo?y hay make a 8recon/ructive tonic & nutri5t0 dose = a man8 ,if an arm load ( ?i/les 7c>duus7 makes a lusci\s food = equus as9us :y %\ld n a p9* ( ?i/le 9 alcohol & wat] be a good 8tonic08 ,great are ! possibilities6 ,!y are limit$ only by ! gullibility ( ! m$ical pr(ession & ! public4 ,c]ta9 x is t "s propriet>y manufactur]s are firmly conv9c$ t no comb9ation c be too prepo/]\s to be wor? try+ on ! m$ical pr(ession4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,aug4 #g1 #aiae47 ,,articles ,,refus$ ,,recognition ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,bel[ appe> ab/racts ( ! ,c\ncil's actions on articles refus$ recognition :i* 7 n deem$ ( suffici5t importance to require l5g?y reports4 ,uricsol ,uricsol is m>ket$ by ! ,uricsol ,*emical ,company1 =m]ly ( ,los ,angeles1 n[ ( ,bo/on4 ,reg>d+ its composition only vague /atem5ts are made4 ,9 an adv]tis+ pamphlet x is promis$ t ! =mula w be s5t to physicians on reque/4 ,su* a reque/ f a physician elicit$ ! foll[+ /atem5t3 8,,uricsol is a non-irritat+1 alkal9e solution1 conta9+ ,li?ium ,citrate1 ,acid ,citric & ,potassium ,nitrate1 toge!r ) a sal9e laxative 9 ! =m ( ,glyc]o ,sodium ,phosphate1 ) ,vegetable ,tonics add$40 ,! ,association ,laboratory has made an exam9ation ( ,uricsol to det]m9e its composition & reports z foll[s3 ,,laboratory ,,report ,a trade package pur*as$ 9 ,m>*1 #aiae1 f a :olesale drug h\se 0 label$3 8,uricsol ,rheumatic ,rem$y1 ,uric ,acid ,solv5t1 ,kidney & ,liv] ,/imulant1 ,manufactur$ by ! ,uricsol ,*emical ,co41 ,los ,angeles1 ,cal40 ,?is package 0 wrapp$ 9 a circul> entitl$ 8,! ,great ,cali=nia ,rem$y--,uricsol40 ,! prep>ation is a viscid1 slightly turbid light br[n liquid1 ) a fa9tly aromatic odor & a salty1 bitt] ta/e4 ,! dilut$ solution is acid 9 reaction t[>d litmus & ph5olph?ale9 & alkal9e t[>d me?yl orange4 ,qualitative te/s %[$ a pres5ce ( phosphate1 citrate1 nitrate1 sodium1 glyc]91 & a small am\nt ( li?ium 9 aque\s solution4 ,besides ^! a small am\nt ( "s organic1 nonalkaloidal sub/ance 0 f\nd1 :i* f its bitt] ta/e sugge/$ g5tian4 ,f ! qualitative te/s x appe>$ t ! phosphate 0 ! pr$om9at+ +r$i5t & accord+ly a phosphate det]m9ation 0 made4 ,! results1 calculat$ to sodium phosphate1 ,u4 ,s4 ,p41 indicat$ ! pres5ce ( #fd4bj gm4 p] #ajj c4c41 held 9 solution by citric acid & sodium nitrate4 ,uricsol evid5tly is a solution conta9+ a l>ge am\nt ( sodium phosphate ) small am\nts ( li?ium1 nitrate1 citric acid & glyc]91 ) probably "s vegetable extract4 ,9 g5]al ,uricsol is simil> to ! once widely exploit$ propriet>y 8,mela*ol10 :i* has be5 frequ5tly imitat$4 ,a prep>ation ess5tially id5tical is 9 ! ,unit$ ,/ates ,ph>macopeia1 "u ! title 8,comp\nd ,solution ( ,sodium ,phosphate40 ,! ,uricsol ,company calls its prep>ation 8444 ! late/ ^w 9 ! treatm5t ( ,rheumatism & t alli$ gr\p ( ailm5ts :i* is caus$ by an excess ( ,uric ,acid40 ,hay fev]1 bron*ial a/hma & neuritis are conditions 9 :i* x is recomm5d$4 ,! claim is made t 8,uricsol quickly controls ,vasomotor ,rh9itis & elim9ates su* conditions f ! sy/em40 8,9 fact1 x w correct ,,faulty ,,metabolism40 ,to a few practition]s ( an old] g5]ation ! ph>macologic basis ( a rem$y = rheumatism 0 suffici5tly def9$ by say+ t x increas$ ! solubility ( uric acid or affect$ x 9 "s way4 ,?is !ory is obsolete2 !re is n1 & nev] 01 any reliable evid5ce on :i* to base ! !ory t rheumatism is 9 any way caus$ by uric acid4 ,! exploitation ( ,uricsol z a 8uric acid solv5t0 is m]ely ano!r illu/ration ( ! way 9 :i* no/rum manufactur]s play on disprov$ !ories4 ,( c\rse ! claim t sodium phosphate has any p>ticul> p[] to control vasomotor rh9itis1 hay fev]1 a/hma1 & to correct faulty metabolism is fooli%4 ,to summ>ize3 ,uricsol is a mixture ( well-kn[n drugs1 m>ket$ ) false claims z to !rapeutic action1 ) mislead+ & mean+less /atem5ts z to composition & "u a "n :i* invites uncritical prescrib+4 ,uricsol is held ineligible to inclusion 9 ,new & ,non(ficial ,rem$ies4 ,jubol ,! foll[+ ridicul\s /atem5ts are address$1 n to ! laity1 b to ! m$ical pr(ession3 ,,d ,,y ,,suff] ,,f ,con/ipation--,hemorrhoids--,ent]itis--, muc\s dis*>ge--,pituita--,acidity ( ! /oma*--,v]tigo--,sick ,heada*e--,di/urb$ ,sleep--,insomnia--,sall[ ,complexion--,coat$ ,tongue--,(f5sive brea?--,fatigue & depression--,boils--,pimples8 8,,"o ( ^! symptoms alone %[s t !re is defective or insuffici5t function ( ! inte/9es1 ev5 if ! /ools are regul>4 8,excrem5ts rema9 too long 9 ! inte/9e & set up f]m5tation4 ,! h>mful poisons & ,ptoma9s :i* !y produce are re-absorb$ by ! blood & poison ! :ole sy/em4 8,! ,inte/9es mu/ be cle>$ & re-educat$ ) ,,jubol4 8,jubolise y\r ,inte/9es40 ,jubol tablets are sold 9 ! ,unit$ ,/ates by ,geo4 ,j4 ,wallau1 ,inc41 ,new ,york1 & are said to be prep>$ by ,j4 ,l4 ,*atela91 ,p>is1 ,france4 ,! foll[+ incomplete & nonquantitative 8=mula0 is furni%$3 8444 comp\nd$ *iefly 6 ( ,ag>-,ag>1 ,bili>y ,extracts & pure ,extracts f all ! inte/9al ,gl&s40 ,x is ass]t$ t 8,! tablets are coat$ ) a protective cov]+ 9 ord] t !y may act on ! inte/9e only40 ,! tablets conta9$ 9 a regul>-size trade package1 obta9$ direct f ! ag5t1 readily sep>at$ into two halves & dis9tegrat$ )9 a few m9utes :5 agitat$ ) wat]4 ,x is ?us evid5t t1 "u ord9>y conditions1 ! inte/9al f]m5ts 9 ,jubol 7if !y are pres5t1 z claim$7 w\ld be de/roy$ dur+ _! passage ?r\gh ! /oma*4 ,9 direct te/s1 h[ev]1 practically no tryptic activity 0 demon/rat$4 ,! composition ( ,jubol is n decl>$2 grossly unw>rant$ & incorrect claims are made = its !rapeutic actions2 ! "n does n indicate ! alleg$ +r$i5ts & s mu* ( ! composition z is decl>$ indicates an unsci5tific mixture4 ,! ,c\ncil decid$ t ,jubol %\ld be held ineligible = ,new & ,non(ficial ,rem$ies1 & t ?is report %\ld be publi%$4 ,urodonal ,urodonal is said to be 8produc$ 9 ! laboratory ( ,j4 ,l4 ,*atela910 ,p>is1 ,france4 ,x is m>ket$ 9 ?is c\ntry by ,geo4 ,j4 ,wallau1 ,inc41 ,new ,york4 ,! prep>ation is claim$ to be a *emical comp\nd1 & ! adv]tis+ matt] furni%es a 8=mula10 :i* consi/s ( ! =mulas ( lysid91 sidonal & hexame?yl5am91 connect$ by plus signs3 ,h,c ,az ,,co,h--,c--,,oh ,az,h ,az ,h,c ,c--,,* ,h,c ,,*oh ,h,c ,,* ,h,c ,,* ,,* ,az,h ,,ohhc ,,* ,h,c ,,* ,az4,,* ,az4,,* ,az ,,*o ,az,h ,,* ,t ! sub/ance is a *emical comp\nd is highly improbable1 & no evid5ce has be5 submitt$ to sub/antiate ! claim4 ,on ! contr>y1 9 ! foll[+ /atem5t ! phrase 8bas$ on0 is a virtual admission t ! prep>ation is m]ely a mixture3 8,urodonal 444 is a granul> eff]vesc5t prep>ation bas$ on me?ylglyoxalid9e ,lysid9e1 qu9ate ( die?yl5e-diam9e ,sidonal & hexame?yl5e-tetram9e ,=m91 urotrop9e40 ,my/]y is add$ by ! m5tion ( undef9$ 8special products0 9 ! foll[+3 8,! fact ( comb9+ ^! two salts lysid9 & sidonal 9 ,urodonal1 9 /rictly det]m9$ proportions & 9 ! pres5ce ( special products1 gives ?is prep>ation v consid]able p[] 9 dissolv+ uric acid40 ,^! contradictory /atem5ts ( composition conflict ) ,rule #a4 ,urodonal is m>ket$ 9 typical 8pat5t m$ic9e0 /yle3 ! "n 8,urodonal0 is bl[n 9 ! bottle & ! label conta9s a li/ ( 8,indications10 includ+ rheumatism1 g\t & gravel 7,rule #d74 ,t ?is =m ( m>ket+ has introduc$ x to ! public is sugge/$ by ! foll[+ 9 an adv]tis+ circul>3 8444 ,urodonal is n[ popul>--ev5 classic--?r\gh\t ! _w1 :]e ?\s&s ( doctors & millions ( pati5ts agree 9 ass]t+ t #8,urodonal is to rheumatism :at qu99e is to fev]4'0 ,!re are also o!r indications t ! mixture is to be exploit$ to ! laity4 ,= in/ance1 ! ,u4 ,s4 di/ributor s5ds out a portrait ( ,s>ah ,b]nh>dt be>+ ! leg5d3 8,i am positive t ,,urodonal pres]ves y\?'s fre%ness ) cle>ness & /r5g? to bra9 & he>t4 ,i h tak5 x = two ye>s ) ! greate/ b5efit4 ,s>ah ,b]nh>dt40 ,a circul> advises ?is mixture 8,= all :o suff] f ,ar?ritis1 ,rheumatism1 ,art]io-,scl]osis1 ,r5al & ,bili\s ,li?iasis1 ,heada*e1 ,g\t1 ,gravel1 ,lumbago1 ,sciatic ,pa9s1 ,neuralgia & all uric acid tr\bles40 8,9 fact1 ,urodonal is five times m active ?an pip]az9e1 & ?irty-sev5 times m active ?an li?ia4 ,we are1 !re=e1 entitl$ to say t no o!r elim9ator ( uric acid c be comp>$ ) x40 8,be+ #cg times m active ?an li?ia1 x cle>s ! he>t valves ( any s&y sub/ances :i* may clog !m1 & *ecks ! a!romat\s deg5]ation ( ! blood vessels40 ,^! extracts indicate suffici5tly ! extravagant tone ( ! adv]tis+ 7,rule #f73 ,none ( ! +r$i5ts are notably active 9 dissolv+ uric acid :5 adm9i/]$ by m\?4 ,none produce any m>k$ increase ( uric acid elim9ation4 ,no intellig5t physician w\ld use a uric acid solv5t = 8bili\s li?iasis02 & _! usefulness 9 ! o!r conditions is op5 to d\bt1 to put x mildly4 ,al?\gh ! prep>ation is a simple mixture1 ! "n does n indicate ! compon5ts1 b incl9es to !rapeutic sugge/ion 7,rule #h74 ,no?+ is to be ga9$ by comb9+ sev]al drugs :i* are useless1 sev]ally1 = ! purpose int5d$1 z 9 ! pres5t case 7,rule #aj74 ,urodonal is m>ket$ "u inconsi/5t /atem5ts ( composition & ) exagg]at$ !rapeutic claims2 ! "n is nondescriptive & ! mixture is unsci5tific4 ,! ,c\ncil decid$ t ! prep>ation %\ld be decl>$ ineligible = conflict ) ,rules #a1 #d1 #f1 #h & #aj & t ?is report %\ld be publi%$4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,aug4 #ad1 #aiae47 ,,=mam9t ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! foll[+ report has be5 au?oriz$ = publication4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,=mam9t is a propriet>y m$ic9e manufactur$ by ! ,a4 ,wulf+ ,company 7,new ,york1 ,london & ,b]l971 :i* is affiliat$ ) ! ,bau] ,*emical ,company4 ,x has be5 widely adv]tis$ 9 ,europe = sev]al ye>s1 & is n[ on ! ,am]ican m>ket2#ad x is adv]tis$ 9 ?is c\ntry bo? 9 newspap]s & m$ical j\rnals4 #ad ,! ,j\rnal ,a4 ,m4 ,a41 ,feb4 #bd1 #aiab1 p4 #egb4 ,foll[+ is a brief review ( ! m important alleg$ inve/igations t h be5 report$ f "t to "t 9 v>i\s ,european j\rnals4 ,9 8,! ,!rapeutical ,value ( ,=am9t 9 ,septic ,affections ( ! ,oro-,ph>ynx10 ,de ,santi#ae quotes ,ros5b]g1#af :o reports ! successful use ( ,=mam9t 9 cases ( /reptococcus infections1 tonsillitis & acute symptoms ( *ronic sore ?roat4 ,accord+ to ,seif]t1#ag ,=mam9t is a *emical comb9ation ( =maldehyd & milk sug>4 ,:5 ! tablets are dissolv$ 9 ! saliva1 #j4ja p] c5t4 ( =maldehyd 9 its 8/atus nasc5di0 is lib]at$ & ex]cises a /rong dis9fectant action4 ,seif]t /ates t ! prep>ation is m>k$ly palatable1 s9ce x conta9s a little citric acid to r5d] ! ta/e cool & refre%+4 ,9 "s exp]im5ts ) /reptococci1 pneumococci1 typhoid & diph!ria bacilli1 ,seif]t f\nd t a solution ( "o tablet 9 #aj c4c4 ( wat] de/roy$ ^! g]ms 9 f five to t5 m9utes4 ,a solution ( ! same /r5g? 0 also add$ to culture tubes ( bro?1 ag>1 & gelat91 ) ! result t no gr[? occurr$ 9 !m1 :ile di/9ct & *>act]i/ic developm5t ( ! bact]ia took place 9 control tubes4 ,he does n /ate1 h[ev]1 h[ mu* ,=mam9t solution 0 add$ to ! m$iums4 #ae ,de ,santi3 ,m$ical ,magaz9e #af3ada1 #aijg4 #af ,ros5b]g3 ,lancet1 ,london #b3ahga1 #aije4 #ag ,seif]t3 ,ph>makol4 u4 !rap4 ,runds*au1 #aijd1 ,no4 #ad2 quot$ by ,de ,santi 7,note #b74 ,daus#ah reports successful treatm5t ( tonsillitis1 mumps & middle e> diseases4 ,9 ^! cases no o!r g>gles or m\? wa%es 7 us$4 ,he /ates t no indication ( irritant or o!r injuri\s action made its appe>ance ev5 aft] l>ge doses4 ,9 ! same article1 ,f4 ,levy reports exp]im5ts z foll[s3 ,ag> plates 7 prep>$ ) a culture ( /reptococcus f a sev]e case ( qu9sy4 ,"o half ( ! plate 0 rubb$ ) saliva conta9+ ,=mam9t 9 solution4 7,! /r5g? ( ! solution us$ is n giv547 ,9 tw5ty-f\r h\rs /reaks ( gr[? _h appe>$ on "o portion ( ! plates :ile ! "p on :i* ! ,=mam9t saliva _h be5 rubb$ rema9$ /]ile4 ,daus also f\nd t ag> & bro? cultures ( /reptococcus %ak5 ) ,=mam9t saliva rema9$ /]ile4 #ah ,daus3 ,m$4 ,kl94 #b3daaj1 #aijf4 ,rhe9boldt1#ai inve/igat+ ! effects ( ,=mam9t & ( ord9>y =maldehyd on animals1 concludes t =maldehyd is toxic 9 action :ile ,=mam9t is n4 #ai ,rhe9boldt3 ,deuts*4 m$4 ,w*ns*r4 #cb3ehg1 #aijf4 ,illu/ration3 ,h[ ! exploit]s ( ,=mam9t capitalize ! m$ical pr(ession4 ,m9iature reproductions ( typical ,=mam9t adv]tisem5ts appe>+ 9 ! newspap]s4 ,ros5b]g#bj corroborates ?is /atem5t4 ,he also f\nd t ag> plates ( ,bacillus prodigiosus 7 kill$ by ,=mam9t solutions 9 ab\t f\r h\rs4 ,he fails1 h[ev]1 to give ! /r5g? ( 8 ,=mam9t solutions4 #bj ,ros5b]g3 ,!rap4 d4 ,geg54 #g3ee1 #aije4 ,w+rave#ba sugge/s ! use ( ,=mam9t = infants6 ,he recomm5ds t a tablet be cru%$ & wrapp$ 9 8butt] clo?40 ,! ends ( ! clo? are to be ti$ ) ?read1 ! ,=mam9t is to be moi/5$1 & ! packet is to be held 9 ! m\? ( ! baby sev]al times ea* day4 #ba ,w+rave3 ,lancet1 ,london #b3ajfg1 #aijf4 ,"y#bb publi%$ ! results ( "s exp]im5ts by himself & ,delp9e on ! human ?roat4 ,!y dissolv$ a tablet 9 ! m\? & made swab cultures ) ! foll[+ results3 ,imm$iately aft] tak+ ! tablet #j colonies #aj m9utes aft] tak+ ! tablet #ce colonies #cj m9utes aft] tak+ ! tablet #aej colonies #bb ,"y3 ,lancet1 ,london #a3ige1 #aijh4 ,!y f\nd no /aphylococci at any "t4 ,o!r results ( swabb+ v>i\s p>ts ( ! ?roat be=e & aft] ! use ( ,=mam9t1 report$ by ^! inve/igators1 %[ enorm\s r$uctions 9 ! c\nt1 claim$ to be due to ! action ( ,=mam9t4 ,! c\nt 0 made on ag> at #cg ,c41 b !y fail to /ate ! "t elaps+ betwe5 tak+ ! ,=mam9t & mak+ ! swab4 ,"y also reports favorable cl9ical results 9 cases ( sc>let fev]1 diph!ria1 sore ?roat1 & ! l4 ,x mu/ be not$1 h[ev]1 t !y /ate t ! m\? & fauces mu/ fir/ be ?or\ghly cleans$ by swabb+ & d\*+ be=e ,=mam9t is us$4 ,,! 8,,*emical ,,comp\nd0 ,,claim ,! claims made 9 ! adv]tis+ lit]ature ( ,=mam9t are v extravagant4 ,_m are highly improbable4 ,^! /atem5ts w be discuss$ lat]4 ,! /atem5t is made t ,=mam9t is a new *emical comp\nd3 8,=mam9t is ,p5tame?anallactose1 #e ,,*oh ,c,h,o4 ,x is an orig9al comb9ation ( ,=maldehyde ) ,lactose1 a def9ite *emical comp\nd4 ,! ,=maldehyde molecule is lock$ up 9 x until solution 9 ! saliva takes place1 :5 ! ,=maldehyde is lib]at$ 9 its nasc5t /ate & is !re=e active )\t be+ irritant40 ,fur!rmore ! mak]s cont5d t ?is new *emical comp\nd is entirely h>mless4 ,= example1 ,daus1#e 9 an article on 8,! ,dis9fectant ,action ( ,=mic ,aldehyde on ,muc\s ,membranes10 decl>es3 8,no indication ( irritant or o!r injuri\s action made its appe>ance ev5 aft] l>ge doses4 ,! ur9e rema9$ free f album9 & sug>40 ,su* /atem5ts z ^! are f\nd 9 ! adv]tis+ lit]ature3 8,=mam9t tablets are absolutely h>mless & innocu\s1 ev5 to little *ildr540 8,:5 dissolv$ 9 ! saliva1 ,=mam9t ,tablets lib]ate sl[ly ,nasc5t ,=maldehyde 9 a mo/ active yet non-irritant =m40 ,!y ma9ta9 t ,=mam9t is n only absolutely h>mless1 b actually b5eficial to ! tissues4 ,x may be us$ 8to tone up & /r5g!n ! tissues1 prev5t ho>s5ess1 & allay irritation 9 s+]s1 public speak]s10 etc4 ,! claims urg$ z to its g]micidal p[] are inde$ glitt]+4 ,?is 8new *emical comp\nd0 is claim$ to lib]ate =maldehyd 9 "s new & peculi> condition :i*1 :ile x has a soo?+ & tonic effect on ! cells ( ! human tissues1 c at ! same "t quickly kill any =m ( bact]ial life4 8,dissolv+ readily1 x releases its g]micidal1 antiseptic qualities1 :i* impregnate ! saliva & are c>ri$ naturally & easily ar\nd ! m\? & 9 ! deepe/ crevices ( ! ?roat--de/roy+ ! g]ms :]e !y are caus+ ! mis*ief4 ,=mam9t prev5ts & de/roys infecti\s g]m life 9 a soo?+ grateful way40 8,9 ! saliva x frees a g]micide1 fatal to g]ms b h>mless to ! mo/ delicate membranes4 ,& fl[+ into e t9y corn] ( ! gums1 tonsils & ?roat1 into places :]e no g>gle ev] rea*es1 x mo/ effectively dis9fects ! ?roat40 ,! claims z to ! prev5tive & curative effects ( ! prep>ation cov] a l>ge portion ( ! category ( human ailm5ts & di/resses4 ,! foll[+ quotations indicate "s ( its suppos$ prop]ties3 8444 x is !re=e self-evid5t t ,=mam9t %\ld be look$ ^u z a necess>y "p ( ! treatm5t ( all =ms ( tonsillitis40 8,! value ( ,=mam9t is equally great 9 diph!ric tonsillitis1 or z a prophylactic 4440 8,! extraord9>y success :i* ,i _h ) ,=mam9t 9 a s*ool epidemic ( sc>let fev] dur+ ,may & ,june1 #aijg1 0 ! det]m9+ factor :i* induc$ me to ab&on ! use ( inhalations1 g>gles1 local applications 9 ! treatm5t ( diseases ( ! ?roat1 & to use ,=mam9t exclusively = ! future40 8,!re are naturally _m simil> conditions 9 :i* ,=mam9t may be us$ z a prophylactic1 notably sc>let fev]1 mumps1 /reptococcal & /aphylococcal sore ?roats1 #8milk outbreaks' ( sore ?roat1 dra9 ?roats1 hospital ?roats1 & ! l40 8,=mam9t ,tablets are indicat$ 9 ,ang9a1 ,tonsillitis1 ,ph>yngitis1 ,/omatitis1 ,g+ivitis1 ,glossitis1 ulc]ation1 spongy or ble$+ gums1 ,pyorrhea ,alveol>is1 #8,smok]'s ,sore ,?roat1' ,abscess or ,boils1 etc40 8,z a ,prophylactic aga9/ ,diph!ria1 ,sc>let ,fev]1 ,influ5za1 ,measles1 ,epidemic poliomyelitis1 & o!r pa?og5ic micro-organisms4 ,to neutralize putrefaction products 9 & ab\t ! tee?1 correct f]m5tative processes1 deodorize & purify ! brea?1 etc40 8,to tone up1 & /r5g!n ! tissues1 prev5t ho>s5ess & allay irritation 9 s+]s1 public speak]s1 neutralize ! effects ( du/-infection or dis9fect ! saliva or sputum 9 ,influ5za1 ,tub]culosis1 etc40 ,"o man decl>es t along ) specific con/itutional treatm5t he 8_h ! be/ results f ! use ( ,=mam9t tablets0 9 a case ( syphilitic ulc]ation ( ! tongue4 ,9 %ort1 ,=mam9t is recomm5d$ = ! treatm5t or prev5tion ( almo/ ev]y?+1 f a bad brea? to su* grave conditions z sc>let fev]1 diph!ria & tub]culosis1 conditions 9 :i* a delay 9 prop] treatm5t--= in/ance1 9 diph!ria1 a failure to adm9i/] antitox9--may result 9 ! dea? ( ! pati5t4 ,a s]ies ( inve/igations 0 !re=e und]tak5 9 ord] to discov] :e!r ! extravagant claims reg>d+ ! g]micidal p[] ( ,=mam9t c\ld be v]ifi$4 ,exp]im5tal ,data ,two fifty-c5t bottles ( ,wulf+'s ,=mam9t 7 pur*as$ 9 ! op5 m>ket & 7 kept well /opp]$ to prev5t det]ioration4 ,qualitative te/s %[$ ! pres5ce ( =maldehyd & ! am\nt 0 det]m9$ quantitatively by ! hydrog5 p]oxid me?od z giv5 by ,sutton4#bc ,! results 7 respectively1 #a4ii p] c5t4 & #b4jc p] c5t4 ( =maldehyd4 #bc ,sutton3 ,volumetric ,analysis1 ,edition #aj1 p4 #cij4 ,illu/ration3 ,two ,=mam9t adv]tisem5ts reproduc$ 9 m9iature typical ( ^? appe>+ 9 a c]ta9 type ( m$ical j\rnals4 ,"s det]m9ations 7 made ( ! g]micidal p[] ( ,=mam9t 9 vitro1 t is1 "u controll$ laboratory conditions4 ,a tw5ty-f\r-h\r pla9 ag> culture ( ,/aphylococcus aureus 0 wa%$ (f 9 #aj c4c4 ( /]ile #j4he p] c5t4 sodium *lorid solution4 ,a #a3ajj1jjj dilution ( ?is 0 made 9 ea* ( ?ree flasks conta9+ #ajj c4c4 ( /]ile saliva4 ,flask #a conta9$ #a p] c5t4 ( ,=mam9t1 ,flask #b1 #e p] c5t42 ,flask #c1 conta9+ no ,=mam9t1 0 kept z a control4 ,at int]vals samples 7 remov$ & dilutions made & plat$ 9 duplicate on /&>d ag>4 ,! plates 7 incubat$ tw5ty-f\r h\rs at #cg ,c41 & plates conta9+ less ?an #bjj colonies 7 c\nt$4 ,! results are giv5 9 ,table #a4 ,aft] sev5 days !re 0 no appreciable diff]5ce 9 ! plates4 ,ano!r te/ 0 made by add+ a #a p] c5t4 ,=mam9t solution to pla9 ag> plates inoculat$ ) ,b4 coli4 ,a tw5ty-f\r-h\r pla9 ag> culture ( ,b4 coli 0 wa%$ (f 9 #aj c4c4 ( /]ile #j4he p] c5t4 sodium *lorid solution4 ,a #a3a1jjj1jjj dilution 0 made ( ?is & #a c4c4 add$ to ea* plate4 ,v>y+ am\nts ( #a p] c5t4 solution ( ,=mam9t 7 add$ to ea* plate4 ,!y 7 incubat$ sev5ty-two h\rs at #cg ,c4 ,aft] sev5 days' incubation ! c\nt 0 ! same4 ,! results are giv5 9 ,table #b4 ,ano!r exp]im5t 0 made ?us3 ,"o loopful ( a tw5ty-f\r-h\r pla9 ag> culture ( ,/reptococcus lacticus 0 mix$ ) a tube ( ,nor? m$ium4 ,"o loopful f ! inoculat$ tube 0 mix$ ) a second tube ( ,nor? m$ium4 ,bo? tubes 7 p\r$ into ,petri di%es & all[$ to cool4 ,"o half ( ea* plate 0 well sme>$ ) a #aj p] c5t4 solution ( ,=mam9t 9 saliva4 ,aft] tw5ty-f\r h\rs' incubation at #cg ,c41 only a few colonies appe>$ on ! side to :i* ! ,=mam9t _h be5 appli$1 :ile ! o!r half 0 ?ickly cov]$ ) colonies4 ,,table #a4--,,%[+ ,,"t ,,9 ,,:i* ,,cultures ,,( ,,/aphylococcus ,,aureus ,,7 ,,kill$ ,,by ,,diff]5t ,,am\nts ,,( ,,=mam9t ,am\nt ( ,=mam9t ,p]iod ( ,av]age ,c\nt ,c\nt on ,flask 9 ,saliva ,/&+ at #cg ,c4 ,:5 ,plat$ ( ,saliva ,)\t 7,p] ,c5t47 7,h\rs7 ,=mam9t ---------------------------------------- -------------------------- #a #c #cb #cbjj #a #f #j #gjjj #e #a ,few #ejjj #e #b #j #dajj #e #c #j #cbjj99 #e #f #j #gjjj99 ---------------------------------------- -------------------------- 99 ,! la/ two obs]vations 7 made at ! same "t z on ! #a p] c5t4 solutions4 ,?is "w s f> corroborates t report$ 9 ! lit]ature quot$ by ! manufactur]s4 ,b ! fact t a comp\nd is a g]micide :5 br\ght into intimate contact ) bact]ia 9 a solution or m$ium 9 a te/ tube or flask does n prove t x w be effective :5 us$ 9 ! human ?roat4 ,,! ,,alleg$ ,,g]micidal ,,action ,an attempt 0 made to discov] :e!r or n ! claims advanc$ by ! manufactur]s z to ! p]fect g]micidal action ( ,=mam9t 9 all ! nooks & crannies ( ! m\? & ?roat c\ld be confirm$4 ,,table #b4--;,,c\nt ,,( ,b4 ,,coli ,,cultures ,,) ,,diff]5t ,,am\nts ,,( ,,=mam9t ,no4 c4c4 ( #a p] c5t4 ,=mam9t #j #j4a #j4c #j4e #j4g #a4j #a4e #b4j #c4j ,c\nt #afj #cc #ci #bf #ae #ab #b #j #j ---------------------------------------- ------------------------------ ,! fir/ /ep 9 attack+ ?is problem 0 to make comp>ative c\nts ( ! numb] ( bact]ia 9 ! ?roat be=e & aft] ! use ( ,=mam9t4 ,! me?ods employ$ 7 z foll[s3 ,! ?roat 0 g>gl$ ) #ej c4c4 ( /]ile #j4he p] c5t4 sodium *lorid solution4 ,9 ea* case ! same l5g? ( "t1 z f> z possible1 0 us$ 9 ! process4 ,! liquid 0 collect$ 9 a /]ile flask4 ,! g>gl+ 9 a s]ies ( exp]im5ts 0 begun n less ?an two h\rs aft] a meal4 ,aft] "s prelim9>y "w ! foll[+ dilutions ( ! #ej c4c4 ( salt solution 7 f\nd suffici5t3 #a3a1jjj1 #a3aj1jjj & #a3ajj1jjj4 ,plates 7 made 9 duplicate f ea* dilution & incubat$ sev5ty-two h\rs at #cg ,c4 ,! c\nts 7 made on plates conta9+ less ?an #bjj colonies4 ,except :]e o!rwise not$ /&>d ag> 0 us$4 ,! m$iums 7 always prep>$ 9 ! same way4 ,all ! "w 0 c>ri$ out "u conditions z ne>ly natural z possible4 ,! ,=mam9t 0 tak5 accord+ to ! directions accompany+ ! trade package4 ,e opportunity 0 giv5 ! ,=mam9t to p5etrate all ! crypts & recesses ab\t ! m\? & ?roat4 ,! tablet 0 all[$ to dissolve z sl[ly z possible1 ! "t usually be+ five to six m9utes1 & saliva 0 ?or\ghly =c$ ar\nd ! m\? be=e be+ swall[$4 ,plat+ 0 always done imm$iately aft] g>gl+ s t no gr[? c\ld occur 9 ! salt solution4 ,! results are giv5 9 ,table #c4 ,! numb]s are av]age c\nts f sev]al plates & calculat$ to %[ ! numb] ( bact]ia wa%$ out by ! #ej c4c4 ( salt solution4 ,,table #c4--,,%[+ ,,t ,,=mam9t ,,does ,,n ,,greatly ,,decrease ,,! ,,numb] ,,( ,,bact]ia ,,9 ,,! ,,?roat ,no4 ,f\nd ,no4 ,f\nd ,"t ,am\nt (9 ,?roat 9 ,?roat ,conditions ( ,te/ ,s9ce ,=mam9t ,be=e ,aft] ,prec$+ ,us$ ,use ( ,use ( ,te/ ,=mam9t ,=mam9t ---------------------------------------- -------------------------- ,normal 444 #j #ae1fjj1jjj 444 ,normal #a h\r #j #ch1ejj1jjj 444 ,normal #a h\r #j #cj1ejj1jjj 444 ,normal 444 #j #ab1ejj1jjj 444 ,normal #a h\r #j #ad1ejj1jjj 444 #a h\r #j #bc1ejj1jjj 444 ,tablet dissolv$ 9 m\? #f days #a tablet 444 #ae1jjj1jjj & ?roat g>gl$ "o h\r lat] ,?roat aga9 g>gl$ two #a h\r #j 444 #aj1jej1jjj h\rs aft] ,=mam9t 0 us$ ,normal #g days #j #fb1jjj1jjj 444 ,normal #a h\r #j #gb1ejj1jjj 444 ,normal 444 444 #fa1jjj1jjj 444 ,tablets 7 tak51 "o #b days #ab 444 #ci1ajj1jjj p] h\r1 & ?roat g>gl$ oneh\r aft] la/ tablet 0 tak5 ,?roat 0 aga9 g>gl$ #b #a h\r #j 444 #ei1jjj1jjj h\rs aft] tak+ la/ tablet ,normal #e days #j #ce1jjj1jjj 444 ,normal #a h\r #j #fb1jjj1jjj 444 ,normal #a h\r #j #gb1jjj1jjj 444 ,"o tablet 0 tak5 ea* #d days #bd 444 #age1jjj1jjj half h\r = #ab h\rs tablets consecutively4 ,?roat 0 g>gl$ "o h\r aft] la/ tablet 0 tak5 ,?roat 0 aga9 g>gl$ #a h\r #j 444 #afh1gej1jjj two h\rs aft] la/ tablet 0 tak5 ,normal #c days #j #abi1fjj1jjj 444 ,normal #a h\r #j #agg1jjj1jjj 444 ,normal #a h\r #j #adg1jjj1jjj 444 ,normal #c days #j #gi1jjj1jjj 444 ,"o tablet 0 tak5 #a h\r #a 444 #hc1bjj1jjj imm$iately aft] prec$- + g>gle4 ,?roat 0 aga9 g>gl$ at end ( "o h\r ,?roat 0 aga9 g>gl$ #b #a h\r #j 444 #acd1gej1jjj h\rs aft] tablet 0 tak5 ,normal conditions except #ai days #j #cb1fjj1jjj 444 t m\? & tee? 7 ?r\ghly wa%$ ) soap j be=e g>gl+ ,same z above #a h\r #j #cc1abe1jjj 444 ,same z above #a h\r #j #dj1cge1jjj 444 ,tee? 7 n wa%$4 #b days #j #cc1ejj1jjj 444 ,o!rwise normal con- ditions ,same z above #a h\r #j #dc1ccj1jjj 444 ,same z above #a h\r #j #ed1jjj1jjj 444 ,same z above #a h\r #j #ej1jjj1jjj 444 ,same z above #a h\r #j #fg1jjj1jjj 444 ,m\? & tee? ?or\ghly #b days #j #e1bgj1jjj 444 wa%$ ) soap j be=e ?roat 0 g>gl$ ,same z above #a h\r #j #aj1iaf1jjj 444 ,same z above #a h\r #j #h1bge1jjj 444 ,normal conditions1 b #a #c days #j #bbh1gej1jjj 444 c4c4 ( /]ile rabbit's blood 0 add$ to ea* plate ,c\nt f ! same g>gle #j #j #fj1fbe1jjj 444 z above4 ,no blood us$ 9 ! plates ,normal conditions1 b #a h\r #j #dca1bej1jjj 444 c\nt 0 made on blood ag> ,c\nt f ! same g>gle #j #j #ei1fbe1jjj 444 asabove4 ,no blood us$ 9 ! plates ,normal conditions1 c\nt #b days #j #fhc1cjj1jjj 444 0 made on blood ag> ,same g>gle z above1 b #j #j #eh1ejj1jjj 444 c\nt 0 made on pla9 ag> ,"o tablet 0 tak5 j #a h\r #a tablet 444 #eeh1cjj1jjj aft] prec$+ g>gle4 ,aft] "o h\r ?roat 0 aga9 g>gl$4 ,c\nt on blood ag> ,same g>gle z above1 b #j #a tablet 444 #ee1hge1jjj c\nt 0 made on pla9 ag> ,normal conditions #b days #j #gi1abe1jjj 444 ,"o tablet 0 tak5 j #a h\r #a tablet 444 #ef1bej1jjj t5 m9utes be=e g>gle #af m94 0 made ,normal conditions #b days #j #df1gej1jjj 444 ,"o tablet 0 tak5 j #a h\r #a tablet 444 #ch1ejj1jjj t5 m9utes be=e ?roat 0 g>gl$ ,tee? & m\? 7 ?or- #e days #j #dg1cgj1jjj 444 oughly wa%$ ) soap j be=e g>gle 0 made ,tee? wa%$ z above & #a h\r #a tablet 444 #ba1bbe1jjj #a tablet tak5 #aj m9utes be=e g>gle 0 made ---------------------------------------- -------------------------- ,f9ally a det]m9ation 0 made ( ! numb] ( /reptococci 9 ! ?roat be=e & aft] ! use ( ,=mam9t4 ,! ?roat 0 g>gl$ 9 ! mann] previ\sly describ$4 ,! /reptococcus c\nt 0 made by ! dilution me?od z giv5 by ,he9emann4#bd ,culture tubes 7 us$ in/ead ( f]m5tation tubes4 ,"o p] c5t4 dextrose bro? 0 ! m$ium employ$4 ,"o cubic c5timet] 0 add$ to ea* ( a s]ies ( t5 tubes = ea* dilution & ! foll[+ dilutions 7 us$3 #a3aj1jjj1 #a3ajj1jjj & #a3a1jjj1jjj4 #bd ,he9emann3 ,laboratory ,guide 9 ,bact]iology1 p4 #hf4 ,! results giv5 9 ,table #d are ! av]age c\nt f a numb] ( dilutions & are report$ z ! total numb] wa%$ out by ! #ej c4c4 ( salt solution4 ,,table #d4--,,%[+ ,,t ,,=mam9t ,,fails ,,to ,,r$uce ,,! ,,numb] ,,( ,,/reptococci ,,9 ,,! ,,?roat ,no4 ,f\nd ,no4 ,f\nd ,"t ,am\nt ( 9 ,?roat 9 ,?roat ,conditions ,s9ce ,=mam9t ,be=e ,aft] ( ,te/ ,prec$+ ,us$ ,use ( ,use ( ,te/ ,=mam9t ,=mam9t ---------------------------------------- ----------------- ,normal 4444 #j #a1bjj1jjj 4444 ,"o tablet 0 tak5 & ?roat g>gl$ "o h\r lat] #d days #a tablet 4444 #ad1gej1jjj ,normal #c days #j #i1iej1jjj 4444 ,"o tablet 0 tak5 & ?roat g>gl$ t5 m9utes lat] #a h\r #a tablet 4444 #h1jjj1jjj ,discussion ,! cont5tion t ,=mam9t conta9s =maldehyd 0 confirm$ by analysis4 ,! manufactur]s also ma9ta9 t ,=mam9t is a new1 def9ite *emical comp\nd1 consi/+ ( five molecules ( =maldehyd & "o molecule ( lactose1 & t :5 dissolv$ 9 ! saliva ! =maldehyd is lib]at$ 9 "s new & peculi> =m1 :i* !y call nasc5t =maldehyd4 ,?is new k9d ( =maldehyd is1 accord+ to ! adv]tis+ lit]ature1 especially p[]ful 9 its g]micidal prop]ties & at ! same "t has absolutely no irritat+ or h>mful effects4 ,,n ,a ,,*emical ,,comp\nd ,?oms1#be reta9$ z an exp]t by ! ,g]man gov]nm5t1 decid$1 aft] a s]ies ( *emical inve/igations1 t ,=mam9t 0 n a def9ite *emical comp\nd1 b t x 0 probably a solid solution ( =maldehyd 9 lactose4 ,he prov$ t :5 ! process ( manufacture 0 c>ri$ out 9 exactly ! way call$ = by ! ,=mam9t pat5ts1 comp\nds conta9+ a great] or less p] c5t4 ( =maldehyd c\ld be made :ile ! o!r prop]ties rema9$ simil> to ^? ( ,=mam9t4 ,! composition ( ! f9al product dep5d$ on ! proportion ( ! compon5ts us$ 9 ! process4 ,!re=e ,=mam9t did n =m a safe means ( uni=m dosage4 #be ,?oms3 ,arb4 a4 d4 ,ph>m4 ,in/4 d4 ,univ]sitt1 ,b]l9 #aa3baj1 #aiad4 ,z a result ( ,?oms' "w ! ,g]man c\rts held t ,=mam9t 0 n a new *emical comp\nd4 ,consequ5tly ! ,=mam9t pat5t 7,numb] #ahijcf7 0 annull$ 9 ,b]l91 ,nov4 #bi1 #aiac4 ,aga9 ! cont5tion t =maldehyd 9 ! nasc5t or active condition is less poison\s & irritat+ ?an 9 its ord9>y =m is contr>y to :at w\ld be expect$ f ! behavior ( su* comp\nds4 ,if x 7 lib]at$1 z claim$1 9 ! 8nasc5t0 condition1 x w\ld be1 = t v reason1 n only m active b also m h>mful4 ,z a matt] ( fact1 ,=mam9t did h an irritant effect on ! work] :o c>ri$ out ^! inve/igations4 ,:5 "o tablet 0 tak5 ea* h\r = twelve consecutive h\rs1 m>k$ irritation ( ! inte/9al tract result$4 ,!re 0 almo/ suffici5t nausea to cause vomit+ & uneas9ess 9 ! alim5t>y canal foll[+ ! exp]im5t4 ,:5 ! tw5ty-f\r tablets 7 tak5 ! results 7 simil> b m pron\nc$4 ,?is is decid$ly 9 contradiction to ! ass]tions ( ! manufactur]s4 ,otto ,seif]t1#bf moreov]1 cites ! foll[+3 8,by ,effects3 ,only a few pati5ts compla9 ( an unpleasant %>p ta/e1 burn+ ( ! tongue 7,seif]t1 ,skl>ek74 ,among ! g5]al symptoms obs]v$ are urtic>ia-l exan!ms 7,glas]1 ,rot]s71 :i* are accompani$ by nausea1 vomit+1 heada*e1 insomnia & v]tigo1 burn+ & irritability especially 9 ! l>ynx 7,meissn]72 ph5om5a ( poison+ 7,geissl]72 ga/ric di/urbances 7,engelmann72 r5al irritation 7,/e9h>d72 unsuit$ = diabetics 7,voit740 #bf ,seif]t1 ,otto3 ,die ,neb5wirkung5 d] mod]n5 ,arzneimittel1 #aiae4 ,! cont5tion t ,=mam9t1 :5 mix$ directly ) m$iums & left 9 contact ) bact]ia1 w kill ! organisms 0 corroborat$4 ,?us ! /atem5ts & pictures 9 ! booklet1 8,! ,gospel ( ,prev5tion10 :i* is enclos$ ) ea* bottle ( ,=mam9t1 %[+ ! inhibition ( gr[? ( air bact]ia on plates conta9+ ,=mam9t are no d\bt true & au!ntic4 ,f9ally1 ! claim t ,=mam9t is an almo/ p]fect ?roat dis9fectant 0 by no means confirm$1 z a glance at ! tables w %[4 ,"o h\r aft] x is tak51 ev5 :5 a tablet 0 us$ ea* half h\r = twelve h\rs1 ! numb] ( bact]ia 9 ! ?roat 0 practically ! same z :5 ,=mam9t 0 n us$4 ,ev5 t5 m9utes aft] tak+ a tablet ! numb] ( bact]ia 9 ! ?roat 0 nev] greatly r$uc$1 z is ma9ta9$ by ! manufactur]s4 ,,has ,,no ,,selective ,,action ,=mam9t ex]ts no selective action 9 kill+ (f ! v delicate organisms :i* are m apt to be pa?og5ic4 ,:5 ! comp>ative c\nts 7 made on blood ag> :i* w\ld favor ! gr[? ( ! delicate p>asitic organisms1 no r$uction :atev] 0 %[n by ! use ( ,=mam9t4 ,! numb] ( /reptococci 0 f\nd to be ! same1 )9 limits ( exp]im5tal error1 t5 m9utes aft] tak+ a tablet z x 0 be=e ! tablet 0 tak54 ,!re=e x seems t ,=mam9t fails1 z any su* g]micide w\ld be expect$ to fail1 to kill bact]ia 9 ! crypts & recesses ( ! ?roat1 = :5 dissolv$ 9 ! m\? x _c rea* & rema9 9 contact ) ! organisms long en\gh to kill !m be=e x is swall[$4 ,,summ>y ,summ$ up1 ! inve/igation %[s3 #a4 ,t ! claims made = ,=mam9t are extravagant & mislead+4 #b4 ,t ! recomm5dations = ! use ( ^! tablets may be1 9 "s cases1 fraught ) dang] & are a m5ace1 n only to ! heal? ( ! individual1 b also to ! safety ( ! community4 #c4 ,t ! claim t ,=mam9t is a def9ite *emical comp\nd is false4 #d4 ,t ! use ( ,=mam9t may produce m>k$ irritation ( ! inte/9al tract4 #e4 ,t ,=mam9t is n a ?roat dis9fectant1 z ! manufactur]s ma9ta91 b its action on ! bact]ia ( ! ?roat is an almo/ negligible "o & dep5d5ce on ,=mam9t = ! prev5tion ( infection & = cur+ disease is n only unwise b dang]\s4 #f4 ,t ,=mam9t conflicts ) ! rules ( ! ,c\ncil4 ,false /atem5ts are made ) reg>d to its composition 7,rule #a72 grossly unw>rant$ claims are made = its !rapeutic prop]ties 7,rule #f71 & !re=e its exploitation to ! public 7,rules #c & #d7 is a public dang]4 ,x is recomm5d$ t ?is report be publi%$1 to call att5tion n only to ! falsity ( ! claims made =1 & ! dang] 9 ! use (1 ,=mam9t1 b also to emphasize ! utt] ineffici5cy ( all su* me?ods ( 8dis9fect+0 ! ?roat4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,aug4 #bh1 #aiae47 ,,hydragog9 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,hydragog9 7,c4 ,bis*(f ,co41 ,new ,york1 sell+ ag5ts7 is adv]tis$ z 8a mo/ p[]ful diuretic & c>diac tonic40 ,! composition giv5 is3 8,fifte5 p>ts ( ! rem$y conta9 #j4e p>ts oxysapon91 #a4e p>ts t9cture ( digitalis1 #b4e p>ts t9cture ( /rophan?us1 scillipicr9 & scillitox91 ! active pr9ciples ( scilla m>itima1 & alcohol40 ,x is n cle> f ?is /atem5t :e!r #ae p>ts ( ,hydragog9 conta9 #b4e p>ts ( t9cture ( /rophan?us1 plus unspecifi$ am\nts ( scillipicr9 & scillitox91 or #b4e p>ts ( a mixture1 9 unspecifi$ proportions1 ( t9cture ( /rophan?us1 scillipicr9 & scillitox94 ,! activity ( /rophan?us1 aft] x ent]s ! blood /ream1 is ab\t fifty times t ( digitalis2 h5ce1 if ! =m] proportion is ! true "o1 9 giv+ an am\nt ( ,hydragog9 :i* ensures ! full !rapeutic effect ( ! digitalis1 "o w\ld adm9i/] an almo/ c]ta9ly fatal am\nt ( /rophan?us4 ,:atev] ! proportion ( /rophan?us may be1 h[ev]1 ! adm9i/ration ( a mixture ( digitalis & /rophan?us 9 fix$ proportions is indef5sible4 ,at times x is advisable to foll[ "o ( ^! drugs ) ! o!r 9 ! treatm5t ( c>diac disease4 ,! simultane\s adm9i/ration ( ! two cont9u\sly 9 fix$ proportions1 h[ev]1 is injudici\s1 because ( ! great diff]5ce betwe5 _! rates ( absorption & 9 _! activity aft] !y ent] ! blood /ream4 ,! action ( digitalis1 moreov]1 p]si/s mu* long] ?an does t ( /rophan?us4 ,an adv]tis+ circul> conta9s ! foll[+ claim3 8,! well-kn[n diuretic prop]ties ( digitalis1 /rophan?us & squills are greatly enhanc$ by ! addition ( ! oxysapon940 ,?is is n true4 ,sapon9s are n syn]gi/ic ) digitalis !rapeutically2 on ! contr>y1 !y ex]t a purely delet]i\s action on ! he>t :5 !y ent] ! circulation4 ,! symptoms ( c>diac disease are (t5 difficult to di/+ui% f ! toxic actions ( ! digitalis bodies4 ,s9ce ^! bodies mu/ (t5 be giv5 to ! po9t ( beg9n+ toxic action 9 ord] to induce ! full !rapeutic effects1 x is obvi\s t ! adm9i/ration ( a mixture ( digitalis1 /rophan?us1 sapon9 & active pr9ciples ( squill is especially liable to induce s]i\s toxic effects :i* _c be di/+ui%$ f ! symptoms ( ! disease4 ,hydragog9 is a %otgun mixture ( semisecret composition2 x is m>ket$ "u a !rapeutically sugge/ive "n1 & adv]tis$ by means ( unw>rant$ !rapeutic claims4 ,x is !re=e 9 conflict ) ,rules #a1 #f1 #h & #aj4 ,! ,c\ncil held ,hydragog9 ineligible = ,new & ,non(ficial ,rem$ies4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,sept4 #d1 #aiae47 ,,filud9e ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,filud9e is said to be prep>$ by ,j4 ,l4 ,*atela91 ,p>is1 & is sold 9 ?is c\ntry by ,geo4 ,j4 ,wallau1 ,inc41 ,new ,york4 ,x is (f]$ z a rem$y = 8bili>y insuffici5cy10 8hepatic insuffici5cy10 8inte/9al dyspepsia10 8all affections ( ! liv] 7diabetes1 cirrhosis1 canc]1 etc4710 8mal>ia10 8obesity0 & 8tub]culosis40 ,no quantitative in=mation is furni%$ z to ! composition ( ! prep>ation & !re are notewor?y discrepancies 9 ! v>i\s /atem5ts reg>d+ ! +r$i5ts4 ,9 "o numb] ( 8,treatm5t10 a self-/yl$ 8,review0 ( m$ical lit]ature 7actually devot$ to adv]tis+ ! prep>ations sold by ,wallau71 we are told t 8,?is product ,filud9e is a m conc5trat$ & pot5t extract ( ! liv]1 ) :i* is comb9$ an extract ( ! sple54 ,! liv] & ! sple5 are s intimately int]dep5d5t1 t ! addition ( a spl5>y extract to ! liv] extract is a signal improvem5t f :i* a syn]gi/ic action results4 ,?i>fine is also add$1 z x helps some:at to combat ! anaemia f :i* all diabetics suff] m or less40 ,?i>fine is said to be 8,?iome?yl>s9ate ( ,caffe91 a new salt discov]$ by ,m4 ,*atela940 ,ano!r circul>1 :i* gives an impos+ =mula = 8?i>fine0 or 8?iome?yl>s9ate ( caffe910 /ates t 8,sulphurat$ me?yl>s9ate is an ars5ical prep>ation devoid ( all toxicity on acc\nt ( ! intimate jo9+ ( its compos+ p>ts40 ,& t 8,filud9e c nev] be contra9dicat$40 ,a /atem5t ( composition 9 a lat] numb] ( 8,treatm5t10 h[ev]1 says t bili>y extracts are compon5ts1 9 addition to ! liv] & sple5 extracts4 ,moreov]1 ?i>fine1 ! 8new salt discov]$ by ,m4 ,*atela910 is no long] 8?iome?yl>s9ate10 b 8?ioc9namate ( caffe902 & a new =mula is furni%$ = x4 ,we are told t 8,me?yl-ars9ate _c be us$ 9 cases :]e fev] is pres5t44440 8,m4 ,*atela9 at fir/ /udi$ ! action ( ?iome?yl>s9ate2 cl9ical & physiological exp]im5tation l$ him1 h[ev]1 to adopt ?ioc9namate ( caffe91 ( great] activity & ) no contra9dications40 ,nev]!less ! same abs5ce ( contra9dications 0 urg$ 9 favor ( ,filud9e :5 x 0 said to conta9 ! n[ disc>d$ ?iome?yl>s9ate ( caffe94 ,! foll[+ are "s ( ! unw>rant$ & ev5 absurd claims3 8,filud9e re/ores ! liv]'s functions4 ,x is to ! liv] :at digitalis is to ! he>t2 x ov]comes ! insuffici5cy & /imulates ! debilitat$ organ40 ,9 mal>ia 8x is ! only true specific :5 associat$ ) qu99e40 8,filud9e is 444 ! ideal m$ication = tub]culosis1 con=m+ z x does ) ! mo/ rec5t rese>*es 9 ! !rapeusis ( ?is affection40 8,we w n g z f> z to say t ,opo!rapy completely re/ores unheal?y liv]s1 = al?\gh ! lesions ( ! hepatic p>5*yma may be oblit]at$ by reg5]ation1 ! lesions ( ! connective tissues are p]man5t1 & may be obs]v$ at ! po/mortem exam9ation4 ,! new cells1 h[ev]1 d n pres5t ! same unheal?y conditions z ^? ( ! =m] diseas$ gl& :i* !y h replac$1 & ! liv] c !re=e function normally1 s t ! pati5t lives on2 & he is satisfi$ ) t40 8,!re=e1 :ile reg5]at+ ! liv] ) ,filud9e1 we cleanse x & combat its conge/$ /ate ) ,urodonal4 ,we cause x to produce urea f ! excess ( uric acid :i* x conta9s40 8,by ! judici\s & h>moni\s comb9ation ( ! b5eficial effects ( ,filud9e & ,urodonal1 physicians n only possess ! means ( treat+ by rational me?ods ,cirrhosis ( ! ,liv] 9 its v>i\s =ms 7:i* is "o ( ! mo/ t]rible diseases :i* c afflict anyone7 b :at is /ill bett]1 !y c cure x40 8,! liv] ( a p]son suff]+ f obesity be+ incapable ( fulfill+ its functions 9 reg>d to ! fatty tissues1 ! rational & up-to-date me?od ( treatm5t is !re=e to re/ore to ! sy/em1 9 ! =m ( ,filud9e1 ! liv] extracts :i* are lack+40 ,filud9e is a mixture ( semisecret composition4 ,! !rapeutic claims are manife/ly unw>rant$4 ,! "n is n indicative ( ! composition1 :atev] t may be1 & no rational excuse is (f]$ = ! comb9ation ( liv] & sple5 extracts 7) or )\t bile extracts7 ) 8?iome?yl>s9ate0 or 8?ioc9namate0 ( caffe94 ,! ,c\ncil !re=e held ,filud9e ineligible = ,new & ,non(ficial ,rem$ies4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,sept4 #ah1 #aiae47 ,,lactopept9e ,,& ,,elixir ,,lactopept9e ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,mixtures ( peps9 & pancreat9 are !rapeutically irrational2 ! two sub/ances are n indicat$ 9 ! same conditions1 nor c !y act toge!r4 ,"u physiologic conditions1 su* mixtures are *emically impossible3 9 a liquid m$ium ! +r$i5ts de/roy ea* o!r4 ,lactopept9 is manufactur$ by ! ,new ,york ,ph>macal ,association1 ,yonk]s1 ,n4 ,y4 ,x is sold "u ! claim t x conta9s1 peps91 dia/ase1 pancreat91 lactic acid & hydro*loric acid4 ,?is product 0 among ! fir/ propriet>y prep>ations exam9$ by ! ,c\ncil on ,ph>macy & ,*emi/ry4 ,! report ( ! inve/igation 0 publi%$ 9 ,! ,j\rnal1 ,m>* #af1 #aijg1 p4 #iei4 ,! prep>ation 0 f\nd to be practically in]t--8ess5tially a weak sac*>at$ peps910 devoid ( tryptic activity4 ,six ye>s lat] x 0 /ill widely adv]tis$ ) ! same irrational claims4 ,a ref]ee 7,a7 !re=e exam9$ ,lactopept9e 7p[d]$7 = ! ,c\ncil 9 #aiac1 & confirm$ ! previ\s f9d+s4 ,! ref]ee's report 0 publi%$ 9 ,! ,j\rnal1 ,aug4 #b1 #aiac1 p4 #ceh4 ,ne>ly f\r mon?s aft] ?is publication1 ! manufactur] prote/$ aga9/ ! report1 ma9ta9+1 contr>y to ! f9d+s ( ! ,c\ncil1 t ,lactopept9e possesses pancreatic activity & conta9s 8loosely comb9$0 hydro*loric acid4 ,ref]ee ,a !re=e repeat$ 8 exam9ation1 & a second ref]ee 7,b71 indep5d5tly1 exam9$ specim5s ( ,lactopept9e 7p[d]7 pur*as$ on ! op5 m>ket = ! purpose %ortly be=e4 ,a few specim5s exam9$ by ^! two ref]ees %[$ a slight tryptic activity2 mo/ ( !m %[$ none4 ,! am\nt ( hydro*loric acid pres5t 0 insignificant4 ,! reports ( ! two ref]ees 7 ref]r$ to ! manufactur]s1 :o aga9 prote/$ vehem5tly aga9/ ^! f9d+s1 ?is "t on ! gr\nd t ! specim5s 7 old4 ,! manufactur]s also cit$ ! "w ( ?ree *emi/s to disprove ! f9d+s ( ! ref]ees1 & dem&$ t ! ,c\ncil reexam9e ,lactopept9e1 mak+ use ( fre% specim5s4 ,! ,c\ncil refus$ = ! foll[+ reasons3 #a4 ,s long z ! packages ( ,lactopept9e are n dat$1 ! activity ( specim5s kn[n to be fre% is ( no practical importance4 ,! activity ( ! actual m>ket supply is ! only "q ( int]e/ to ! pr(ession4 ,! only fair te/ is t made on specim5s repres5tative ( ! product sold to ! ultimate consum]4 #b4 ,! evid5ce pres5t$ by ! manufactur]s did n w>rant a reexam9ation1 s9ce ! "w ( two ( ! *emi/s cit$ sub/antially corroborates ! results obta9$ by ! ,c\ncil's ref]ees f ! fre%] specim5s4 ,! figures = tryptic activity obta9$ by ! ?ird *emi/ cit$ by ! manufactur]s c\ld n be accept$ by ! ,c\ncil1 s9ce x 0 at v>iance ) all o!r kn[n results ( inve/igations ( ,lactopept9e4 #c4 ,z /at$ at ! outset1 :atev] ! tryptic activity ( ! mixture1 x is !rapeutically useless4 ,a demon/ration ( tryptic activity 9 a mixture conta9+ bo? peps9 & pancreat9 is ( m]ely !oretical int]e/4 ,su* activity1 ( c\rse1 _c be expect$1 ev5 on !oretical gr\nds1 9 liquid mixtures l ,elixir ,lactopept9e4 ,! ,c\ncil !re=e aga9 decl>$ ,lactopept9e 7p[d] & tablets7 & ,elixir ,lactopept9e ineligible = ,new & ,non(ficial ,rem$ies & au?oriz$ publication ( ! foll[+ /atem5t4 ,w4 ,a4 ,puckn]1 ,secret>y ,,! ,,c\ncil',s ,,report ,lactopept9e p[d] 7,new ,york ,ph>macal ,association1 ,yonk]s1 ,n4 ,y47 0 exam9$ by ! ,c\ncil 9 #aijg4 ,at t "t x 0 claim$ to conta9 8444 ! five active ag5ts ( dige/ion--peps91 dia/ase 7veg4 ptyal971 pancreat91 lactic acid & hydro*loric acid--comb9$ 9 ! prop] proportion to insure ! be/ results40 ,! exam9ation %[$ t ! prep>ation 0 ess5tially 8a weak sac*>at$ peps910 conta9+ b small am\nts ( peps91 no hydro*loric acid1 or m]e traces only1 & no dia/ase or pancreat9 7,! ,j\rnal1 ,m>* #af1 #aijg74 ,9 #aiac1 ! product 0 reexam9$1 because ! claims1 z to bo? composition & !rapeutic value1 7 /ill be+ made4 ,samples 7 te/$ bo? ( ! ,am]ican product1 & ( a ,briti% product f ,john ,morgan ,ri*>ds ,sons1 ,london4 ,! orig9al f9d+s 7 confirm$ & ! results 7 publi%$ 9 ,! ,j\rnal1 ,aug4 #b1 #aiac1 p4 #ceh4 ,ne>ly f\r mon?s lat] 7,novemb] #bd7 ! ,new ,york ,ph>macal ,association wrote to ! ,c\ncil1 object+ to ! f9d+s & ma9ta9+ t ,lactopept9e possesses pancreatic activity & conta9s 789 loose *emical comb9ation07 hydro*loric acid4 ,9 accordance ) ! cu/om ( ! ,c\ncil1 ! "w 0 s5t back = review to ! ref]ee 7,a71 ^: conclusions 7 !n te/$ by a second ref]ee 7,b71 a physiologic *emi/1 n a memb] ( ! ,c\ncil1 select$ because ( 8 special k ( ! subject4 ,9 ,decemb]1 #aiac1 ,ref]ee ,a made a l>ge numb] ( new te/s to det]m9e proteolytic & amylolytic p[]4 ,8 results %[ t ! f]m5t activity ( ! prep>ation is s l[ z to m]it no recognition 9 practical use4 ,! te/s also %[ t ! am\nt ( lactic acid or 8loosely comb9$ ,h,cl0 7or bo?7 pres5t is too small to h any appreciable physiologic activity & !re=e to be ( any !rapeutic value4 ,n9e samples ( ,lactopept9e pur*as$ 9 ! op5 m>ket 9 ,decemb]1 #aiac1 & ,janu>y1 #aiad1 7 exam9$ by ,ref]ee ,b e>ly 9 #aiad4 ,8 /udies %[ abs5ce ( amylase 9 all samples2 pres5ce ( peps91 giv+ weak reactions ev5 :5 comp>$ ) ^? ( old peps9 prep>ations2 complete abs5ce ( tryps9 9 sev5 out ( n9e samples1 tryptic reaction be+ obta9$ 9 two samples1 9 "o ( :i* ! reaction1 8slight at be/ & ( no practical import10 0 obta9$ only aft] treatm5t = twelve h\rs or m4 ,! pres5ce ( tryptic activity 9 two out ( ! n9e samples may be due to ! fre%] condition ( ^! specim5s1 z indicat$ by ! s]ial numb]s4 ,! evid5ce %[s t x is a comm]cial impossibility to m>ket mixtures ( peps91 pancreat9 & lactic acid s t !y c display any mat]ial tryptic activity4 ,x %\ld be reaffirm$ t mixtures comb9+ peptic & pancreatic activities are n feasible1 because peps9 _c act except 9 ! pres5ce ( acid1 & pancreat9 is de/roy$ by acid & by peptic activity4 ,fur!rmore1 9 conditions 9 :i* pancreat9 is call$ =1 peps9 is n1 & vice v]sa2 !re=e ! adm9i/ration ( mixtures ( peps9 & pancreat9 w\ld be unju/ifi$1 ev5 if bo? con/itu5ts c\ld be expect$ to ex]t activity4 ,! =ego+ obs]vations apply to ,lactopept9e 9 p[d] & tablet =m4 ,:ile mixtures ( peps9 & pancreat9 are unsci5tific & unju/ifi$1 !oretically ! two sub/ances may coexi/ 9 a solid prep>ation1 & ! activity ( su* a prep>ation is consequ5tly a prop] subject ( inve/igation4 ,!oretically z well z practically1 h[ev]1 peps9 & pancreat9 _c exi/ toge!r 9 solution4 ,! claims made = ,elixir ,lactopept9e & all o!r liquid prep>ations sold z mixtures ( peps9 & pancreat9 are !re=e impossible4 ,! ,c\ncil has previ\sly tak5 action 7,! ,j\rnal1 ,feb4 #b1 #aijg1 p4 #dcd7 refus+ to approve = inclusion ) ,new & ,non(ficial ,rem$ies su* prep>ations1 call+ ! att5tion ( ! m$ical pr(ession & ( manufactur]s to _! wor?lessness1 & reque/+ ! ,am]ican ,ph>maceutical ,association to in/ruct its committee on ! ,national ,=mul>y to omit f ! next edition ( t "w a liquid prep>ation ( peps9 & pancreat9 recogniz$ "u ! title ( 8elixir dige/ivum compositum40 ,x is recomm5d$ t ! ,c\ncil reaffirm ?is previ\s action1 & t ,lactopept9e & ,elixir ,lactopept9e be decl>$ ineligible = ,new & ,non(ficial ,rem$ies because ( conflict ) ,rule #aj 78,no article w be admitt$ :i*1 because ( its unsci5tific composition1 is useless or inimical to ! be/ int]e/s ( ! public or ( ! m$ical pr(ession074 ,manufactur]s' ,prote/ & ,c\ncil's ,answ] ,! =ego+ 0 submitt$1 toge!r ) ! f9d+s ( ! two ref]ees1 to ! manufactur]s4 ,!y prote/$ aga91 alleg+ t3 ,,age ,,( ,,specim5s ,fir/4--,! specim5s ( ,lactopept9e exam9$ by ! second ref]ee 7 old4 ,! dates ( manufacture correspond+ to ! sev]al bat* numb]s are suppli$ by ! manufactur]s z foll[s3 #bbge 7,p[d]7 ,septemb]1 #aijh #bcja 7,p[d]7 ,june1 #aiji #bcab 7,p[d]7 ,decemb]1 #aiji #bcdh 7,p[d]7 ,octob]1 #aiaa #bceb 7,p[d]7 ,decemb]1 #aiaa #bcfd 7,p[d]7 ,july1 #aiab #bcgd 7,p[d]7 ,m>*1 #aiac #bchc 7,p[d]7 ,octob]1 #aiac #afch 7,tablets7 ,octob]1 #aiaa ,! manufactur]s ass]t t !y d n und]/& h[ specim5s ( ^! ages c\ld h be5 pur*as$ on ! op5 m>ket 9 #aiac & #aiad1 inasmu* z _! ag5ts are & long h be5 in/ruct$ to take up f ! druggi/ all lots ( ,lactopept9e :i*1 z indicat$ by ! bat* numb]s1 h atta9$ 8any appreciable age40 ,! age ( ! specim5s1 ! manufactur]s decl>e1 deprives ! table 9 ! second ref]ee's report ( 8all significance or int]e/40 ,z previ\sly /at$1 h[ev]1 ! specim5s ( ,lactopept9e exam9$ 7 pur*as$ on ! op5 m>ket 9 v>i\s localities 9 unbrok5 packages1 9 ,decemb]1 #aiac1 & ,janu>y1 #aiad4 ,!y ?us repres5t /ock us$ 9 fill+ physicians' prescriptions or sold to ! public4 ,nei!r ! ref]ees nor any "o connect$ ) ! ,c\ncil _h any means ( kn[+ ! age ( ! specim5s until ! dates ( manufacture 7 furni%$ by ! ,new ,york ,ph>macal ,association4 ,! fir/ te/s ( ! second ref]ee 7 made 9 ,febru>y1 #aiad1 on ,specim5s #bcgd & #bchc1 :i* 7 !n1 x w\ld appe>1 ab\t "o ye> old & f\r mon?s old1 respectively4 ,! ,c\ncil has repeat$ly urg$ t ph>maceutical sub/ances :i* are subject to det]ioration %\ld be dat$ by ! manufactur]1 & a simil> sugge/ion has be5 made by ! ,bureau ( ,*emi/ry ( ! ,u4 ,s4 ,dep>tm5t ( ,agriculture conc]n+ mixtures conta9+ enzymes4 ,not)/&+ ! in/ructions :i* ! ,new ,york ,ph>macal ,association claims to h giv5 its ag5ts1 ! m>ket supply ( ,lactopept9e 9 ,decemb]1 #aiac1 & ,janu>y1 #aiad1 0 n compos$ ( new /ock1 & until ! manufactur]s adopt ! practice ( dat+ packages1 !re c be no assurance t x w be fre%4 ,9 ?is connection1 x is ( int]e/ to note t ! ,bureau ( ,*emi/ry ( ! ,u4 ,s4 ,dep>tm5t ( ,agriculture has issu$ a w>n+ t x w judge su* products by ! degree ( _! activity :5 !y rea* ! consum]1 i4 e41 z !y are f\nd on ! m>ket4 ,,reports ,,( ,,o!r ,,*emi/s ,second4--,! ,new ,york ,ph>macal ,association cites ! "w ( sev]al *emi/s1 :o h exam9$ ,lactopept9e & report ! pres5ce ( tryptic activity4 ,dr4 ,s4 ,r4 ,b5$ict 9 ,decemb]1 #aiac1 report$ to ! ,c\ncil 8di/9ct0 tryptic activity 7dige/ion 9 twelve h\rs by ,lactopept9e ( #d4b times its weight ( fibr9 conta9+ #ej p] c5t4 moi/ure7 9 specim5s exam9$ by him4 ,^! specim5s 7 numb]$ #bchb1 & 7 !re=e probably manufactur$ 9 ,octob]1 #aiac2 comp>e ! dates furni%$ by ! manufactur] = ! specim5s us$ by ! second ref]ee4 ,no te/s aga9/ o!r prep>ations possess+ tryptic activity are report$1 & ,dr4 ,b5$ict expressly disclaims any op9ion z to ! !rapeutic value ( ! prep>ation4#bg ,dr4 ,p4 ,b4 ,hawk1 ^: report 0 submitt$ by ! manufactur]s1 f\nd 9 ,lactopept9e by ,f]mi's me?od "o-fif? tryptic activity ( t ( ,m]ck's pancreat91 & by ,grtzn]'s me?od an activity ( #ah p] c5t4 ( ! pancreat94 ,a te/ = ! production ( tryptophan 0 report$ positive4 ,! ,new ,york ,ph>macal ,association also submitt$ a report f ,dr4 ,a4 ,w4 ,bal*1 :o f\nd peps91 r5n91 tryps91 /eaps91 amylops9 & lactic acid pres5t 9 ,lactopept9e2 also an am\nt ( comb9$ hydro*loric acid 9 #a gm4 ! equival5t ( #a4je c4c4 t5? normal solution or #j4jjchc gm4 hydro*loric acid4 7,he reports dige/ion 9 tw5ty-f\r h\rs by ,lactopept9e ( #be times its own weight ( fibr94 8,an active extract ( pancreas react$ exactly l ! ,lactopept9e solution407 ,! s]ial numb]s ( ! specim5s te/$ by ,hawk & ,bal* are n giv51 b no d\bt !y 7 fre%4 #bg ,dr4 ,b5$ict's p]sonal communication to a memb] ( ! ,c\ncil is z foll[s3 8,9 ! report ( ! ,c\ncil ^u ,lactopept9e :i* y s5t to me1 ,i f9d ! foll[+ /atem5t3 #8,c>eful exam9ation fail$ to %[ ! pres5ce ( ei!r dia/ase or pancreat94' ,9 ?is connection ,i w cite to y ! foll[+ exp]im5t c>ri$ out by myself3 ,a package conta9+ a #a-ounce bottle ( ,lactopept9e 7p[d]7 ) seal unbrok5 0 pur*as$ 9 ! op5 m>ket & op5$ 9 ?is laboratory4 ,! label bore ! special ,numb] #f #bchb4 ,two hundr$ milligrams ( ?is product 0 dissolv$ 9 #ej c4c4 ( a #j4be p] c5t4 solution ( sodium c>bonate 9 wat]4 ,?is solution 0 divid$ into two portions ( #be c4c4 ea*4 ,"o ( ^! portions 0 boil$ at once1 & aft] cool+ 0 add$ to #a gm4 ( moi/ fibr9 conta9$ 9 a flask4 ,! o!r portion 7unboil$7 0 also add$ to #a gm4 ( moi/ fibr9 conta9$ 9 a flask4 ,bo? flasks 7aft] addition ( #e c4c4 ( tolu5e to ea*7 7 /opp]$ & plac$ 9 an incubator at #cg degrees1 & left !re = twelve h\rs4 ,exam9ation ( ! two flasks at ! end ( ?is p]iod %[$ t ! "o to :i* ! unboil$ solution ( ,lactopept9e p[d] _h be5 add$ conta9$ mu* less solid prote9 ?an did ! o!r4 ,al?\gh ?is fact 0 obvi\s to ! nak$ eye1 ! exact ext5t ( dige/ion 9 ! two flasks 0 det]m9$ by heat+ bo? to boil+1 acidify+ ) acetic acid1 dilut+ to def9ite volume1 filt]+ & det]m9+ ! nitrog5 9 ! filtrate by ,kjeldahl's me?od4 ,subtract+ ! trace ( nitrog5 conta9$ 9 ! filtrate ( ! control flask1 ! results %[$ t #db p] c5t4 ( ! orig9al fibr9 pres5t _h be5 dissolv$ by ! unboil$ ,lactopept9e solution4 ,?is c be ascrib$ only to tryptic activity "u ! conditions ( ?is exp]im5t4 ,fur!rmore1 ?is is n simply a #8trace' ( activity1 b is at lea/ suffici5tly m>k$ to w>rant a /atem5t t ?is sample %[$ a di/9ct tryptic activity4 ,inasmu* z ,i h obta9$ exactly simil> results ) two o!r samples ( ,lactopept9e 7p[d]7 7^! be+ ! only ones ,i h exam9$71 ,i am incl9$ to "q ! correctness ( ! ,c\ncil's /atem5t reg>d+ ! abs5ce ( tryps9 f ?is prep>ation4 ,z not$ above1 a fre% prep>ation 0 us$4--,ed4 8,may ,i aga9 add t ,i am mak+ no /atem5t reg>d+ !rapeutic value ( prep>ation1 & t ,i h no op9ion ^u t matt] "o way or ! o!r8 ,my "w 0 und]tak5 solely out ( int]e/ to see :e!r tryps9 c\ld exi/ 9 ! p[d] 7:i* gives a m>k$ly acid solution :5 dissolv$ 9 wat]74 ,! ,elixir ,lactopept9e c\ld !oretically %[ no tryptic activity1 nor h ,i f\nd any trace ( su* activity 9 "o sample ( ! ,elixir exam9$4 8,9 mak+ use ( any ( ! cont5ts ( my lett]s k9dly include ! /atem5t t my "w ^u ,lactopept9e 0 done )\t remun]ation ( any k9d1 & 0 done only = ! sci5tific int]e/ atta*$ to ! "q40 ,,conclusions ,! ,new ,york ,ph>macal ,association dem&$ t ! ref]ee reexam9e ,lactopept9e1 mak+ use ( fre% specim5s4 ,! ,c\ncil held t ?is 0 unnecess>y1 = ! foll[+ reasons3 #a4 ,! previ\s f9d+ ( ! ,c\ncil1 t specim5s ( ,lactopept9e f\nd on ! op5 m>ket are ess5tially weak sac*>at$ peps9s1 is n to be refut$ by exam9ation ( fre% specim5s4 ,ev5 if x be assum$ t all old specim5s ( ,lactopept9e h be5 )drawn f ! m>ket s9ce ! la/ pur*ase ( specim5s = ! use ( ! ,c\ncil's ref]ee1 !re c be no assurance t ! /ock w be con/antly kept fre%4 ,unless ! manufactur]s date _! product1 physicians _c "k t _! prescriptions are fill$ ) fre% mat]ial4 ,nor is x reasonable to ask t ! ,c\ncil exam9e ! m>ket supply ( any giv5 propriet>y at a "t select$ by ! manufactur]s4 #b4 ,)\t ent]+ into all que/ions ( detail 9 ! analyses1 ! ,c\ncil is will+ to accept ! reports ( ,drs4 ,b5$ict & ,hawk z repres5tative ( fre% ,lactopept9e p[d]4 ,x is !re=e unnecess>y = ! ,c\ncil to make fur!r exp]im5ts along ?is l9e4 ,! results ( ^! two *emi/s 9 no wise contradict ! conclusions ( ! ,c\ncil's ref]ees1 be+ comp>able ) ^? obta9$ by ! ref]ee on ! fre%] specim5s us$ by !m4 ,! exp]im5ts ( ,drs4 ,hawk & ,b5$ict %[ a degree ( tryptic activity :i*1 ?\gh *emically n negligible1 is q )\t significance practically1 ev5 if x c\ld be assum$ t ! tryps9 9 ! fre% ,lactopept9e escap$ de/ruction 9 ! /oma*4 ,! figures = tryptic activity giv5 by ,dr4 ,b5$ict d n diff] mat]ially f ^? ( ! fir/ ref]ee4 ,^? ( ,pr(essor ,hawk %[ a tryptic activity ( f #ah to #bj p] c5t4 ( t ( comm]cial pancreat9--& comm]cial pancreat9s ord9>ily are ( l[ tryptic activity1 if n in]t 7see ,long & ,muhleman3 ,ar*4 ,int4 ,m$41 ,febru>y1 #aiad1 p4 #cad47 ,! reports ( ^! *emi/s pres5t no reason = *ang+ ! conclusion t 8x is a comm]cial impossibility to m>ket mixtures ( peps91 pancreat9 & lactic acid s t !y c display any mat]ial tryptic activity40 ,! results :i* ,dr4 ,bal* obta9$ 9 a te/ = tryptic activity %[ a m>k$ discrepancy ) ^? obta9$ by ,drs4 ,hawk & ,b5$ict1 n to m5tion ! ,c\ncil's ref]ees1 & also ) ! fact t only ab\t #aa p] c5t4 ( 8pancreat90 is claim$ 9 ! publi%$ =mula ( ,lactopept9e4 ,! ,c\ncil is unable to accept ,dr4 ,bal*'s result = tryps9 or r5n9 z reliable4 ,8 o!r results are )\t significance & call = no special comm5t4 #c4 ,ev5 if tryptic activity 7 conc$$ to ,lactopept9e1 ! prep>ation1 l all prep>ations conta9+ peps9 & pancreat91 w\ld /ill be1 z previ\sly /at$1 !rapeutically irrational4 ,! ,c\ncil approv$ ! report4 ,report ( ,ref]ee ,a ,9 view ( ! manufactur]'s reit]ation ( ! claims = ,lactopept9e p[d]1 ,i h c>ri$ out fur!r exp]im5ts to det]m9e its proteolytic & amylolytic p[]4 ,= ! proteolytic te/ ,i us$ fre%1 well wa%$ fibr9 & exam9$ samples ( ,lactopept9e p[d] numb]$ z foll[s3 ,no4 #a4 ,a "p ( ! ,engli% product exam9$ & report$ on la/ spr+4 ,no4 #b4--;,a fre% bottle obta9$ at a ,*icago retail drug /ore 9 ,decemb]1 #aiac4 ,no4 #c4 ,a fre% bottle obta9$ at a ,*icago retail /ore 9 ,decemb]1 #aiac4 ,portions ( #a gm4 ea* ( ^! samples 7 mix$ ) #e gm4 fibr91 #ajj mg4 ( sodium c>bonate & #ej c4c4 ( wat] 9 flasks4 ,a little tolu5e 0 add$ to ea* flask1 :i* 0 !n clos$ ) a tuft ( cotton & ! mixtures 7 incubat$ at #dj degrees ?r\gh tw5ty-f\r h\rs4 ,at ! end ( t "t !re 0 no m>k$ *ange 9 ! quantity ( ! fibr9 rema9+ 9 ea* flask1 ! l>g] "p by f> be+ undige/$4 ,z a control ,i us$ ! sample ( an active comm]cial tryps91 ( :i* ,i add$ #ejj mg4 to ! same quantity ( wat]1 fibr9 & sodium c>bonate4 ,?is 0 dige/$ 9 ! same ba? at ! same "t4 ,! dige/ion 0 practically complet$ 9 less ?an t5 m9utes1 only m9ute flakes ( ! fibr9 rema9+4 ,x is evid5t t ! dige/ive p[] ( ! ,lactopept9e mu/ be extremely l[1 & only a small fraction ( t exhibit$ by a comm]cially good tryps94 ,9 an exp]im5t ) ! ,engli% sample c>ri$ out ?r\gh n9ete5 h\rs z above1 us+ #b gm4 ( fibr9 & #ajj mg4 ( f]m5t1 x 0 f\nd by nitrog5 te/s on ! filtrate t ab\t #ab4b p] c5t4 ( ! prote9 _h be5 br\ght into solution1 an am\nt :i* is practically )\t importance 9 a dige/ion ( su* duration4 ,to te/ ! />* dige/ive p[] ,i h made a l>ge numb] ( exp]im5ts4 ,9 a s]ies j complet$ ,i mix$ #a gm4 portions ( ,samples #a & #b ) wat] to make #ajj c4c4 volumes4 ,be=e mak+ up to ! f9al volumes #j4e c4c4 ( normal sodium hydroxid 0 add$ to neutralize ! slight acidity ( ! f]m5t z %[n by ph5olph?ale94 ,( ^! mixtures #d1 #f1 #h & #aj c4c4 portions 7 mix$ ) #ej c4c4 ( #a p] c5t4 />* pa/e & incubat$ at #dj degrees to f9d ! colorless end-po9t 9 ! />* dige/ion1 by ! iod9 te/4 ,at ! end ( tw5ty-two h\rs ! iod9 reaction 0 z /rong z at ! beg9n+1 indicat+ no appreciable />* dige/ion4 ,to ! flasks 9 :i* no dige/ion _h tak5 place "u ^! conditions1 #e mg4 ( a pancreas f]m5t 0 add$4 ,?is gave an almo/ imm$iate conv]sion to ! colorless end-po9t4 ,?is f]m5t 0 a sample ( ,holad9 :i* _h be5 9 ! laboratory ab\t a ye>4 ,! #e mg4 complet$ ! reaction to ! colorless end-po9t 9 less ?an t5 m9utes4 ,9 a simil> te/ ,i us$ #b gm4 ( ,lactopept9e ,no4 #c1 made up to #ajj c4c4 ) #a4b c4c4 ( normal alkali4 ,t5 & #ae c4c4 portions 7 incubat$ ) #ej c4c4 ( #a p] c5t4 />* pa/e ?r\gh tw5ty h\rs at #dj degrees ) no app>5t result4 ,! ,holad9 !n add$1 #e mg4 be+ us$1 complet$ ! conv]sion 9 less ?an t5 m9utes4 ,?is %[s t ! m$ium 0 a prop] "o = ! te/ & t ! ,lactopept9e mu/ be extremely weak4 ,no sug> te/s 7 made because ! ,lactopept9e conta9s milk sug> to ! ext5t ( ab\t #fj p] c5t4 ,simil> results = bo? prote9 & />* dige/ives h be5 obta9$ 9 a l>ge numb] ( exp]im5ts4 ,^! "h quot$ %[ t ! f]m5t activity ( ! prep>ation is s l[ z to m]it no recognition practically4 ,! dige/ion ( a few milligrams ( fibr9 or />* aft] _m h\rs ( contact1 :ile be+ p]haps sci5tifically possible1 is ( no value :5 we come to a consid]ation ( ! use ( su* bodies z dige/ive f]m5ts 9 m$ic9e4 ,! am\nt ( lactic acid or 8loosely comb9$ ,h,cl0 pres5t 9 ,lactopept9e is v small1 s9ce ! total acid :i* may be titrat$ by sodium hydroxid & ph5olph?ale9 is measur$ by #j4e c4c4 ( ! normal hydroxid = #a gm4 ( ! ,lactopept9e p[d]1 9 ! mean4 ,9 diff]5t samples exam9$ ! range 0 f\nd to be f #j4da c4c4 to #j4f c4c4 ,te/s ) me?yl orange1 me?yl r$ & o!r indicators %[$ t ! free acidity is b trifl+2 if ! :ole ( ?is acid1 z measur$ by ph5olph?ale91 7 calculat$ to ,h,cl1 ! am\nt w\ld be too small to h any appreciable physiologic activity1 9 view ( ! daily dose recomm5d$1 #aj to #bj gra9s ( ! p[d]4 ,report ( ,ref]ee ,b ,! foll[+ table gives a summ>y ( ! results ( my inve/igations on ,lactopept9e4 ,! numb]s 9 ! extreme left-h& column are ! manufactur]'s id5tify+ m>ks4 ,^!1 x is assum$1 run s]ially1 ! high] numb]s indicat+ fre%] specim5s4 ,,table ,,%[+ ,,enzymic ,,p[] ,,( ,,lactopept9e ,,prep>ations ,amylase ,peps9 ,r5n9 ,tryps9 ,lipase #bbge - - - #bcja - - - #bcab - - - #bcdh - - - #bceb - - - #bcfd - 787 - #bcgd - - 787 #bchc - 787 #afch 7tablets7 - - - ,pancreat9 7,old7 - 44 44 - ,! conclusions 9 ! =ego+ summ>y dep5d on ! foll[+ crit]ia3 ,amylase3 removal ( />* 7pa/e71 small 9 proportion to beg9 )4 ,peps93 solution ( small %r$s ( fre% fibr9 9 acid m$ia4 ,r5n93 curdl+ ( milk 9 mod]ate excess4 ,tryps93 solution ( small %r$s ( fre% fibr9 9 neutral & alkal9e m$ia1 & tryptophan te/4 ,lipase3 coloration ( litmus-milk2 exact color controls4 ,all te/s 7 suitably controll$4 ,! responses = peps9 7 weak ev5 :5 comp>$ ) ^? ( old peps9 prep>ations4 ,9 ! table above1 ! int]rogation po9ts 9 p>5!ses 787 ref] to results t 7 obta9$ aft] treatm5t = f twelve to tw5ty-f\r h\rs & indicates t ! *ange 0 slight at be/ & ( no practical import4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,oct4 #bc1 #aiae1 ) additions47 ,,iodum-,,mill] ,,& ,,iod-,,izd-,,oil 7,,mill]',s7 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil adopt$ ! foll[+ report & au?oriz$ its publication4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,a ref]ee has submitt$ to ! ,c\ncil ! foll[+ report ( ! ,*emical ,laboratory ( ! ,am]ican ,m$ical ,association on ,iodum-,mill] & ,iod-,izd-,oil 7,mill]'s7 7,iodum-,mill] ,co41 ,kansas ,city1 ,mo473 ,! unsatisfactory /atem5ts made 9 reg>d to ! composition ( ,iodum-,mill] & ! f>-rea*+ !rapeutic recomm5dations = x induc$ ! laboratory to make a *emical exam9ation ( ! prep>ation4 ,x claim$ m or less directly t ! prep>ation is entirely new & possesses novel *>act]i/ics4 ,x is ass]t$ t 8,iodum-,mill] is made f ,soot ,iod9e1 :i* is our own product4 ,?is ,soot ,iod9e is ,,soluble ,,9 ,,wat] be=e be+ comb9$ ) its base ,c4,p4 ,glyc]9e40 ,no in=mation reg>d+ 8soot iod9e0 is (f]$ & an inquiry s5t to ! proprietors by a physician br\ght only ! noncommittal reply t 8soot iod9e0 8is made f ,resublime resublim$8 ,iod9e by a *emical process :i* r5d]s x soluble 9 wat] be=e be+ comb9$ ) its base40 ,iodum-,mill] is said to conta9 8,active ,free ,iod9e #b4b grams p] #ajj c4c41 #aj4 gra9s p] fluid ounce1 #a4g by weight40 8,9 addition to ! active free iod9e 444 ,,iodum-,,mill] c>ries a /ill great] p] c5t ( ,iod9e 9 its basic comb9ation44440 ,accord+ to ! label1 ! prep>ation is 8,an ,iod9e = ,ext]nal & ,int]nal use 444 #de drops equals #a dr4 by weight4 ,ea* drop equals ! p] c5t4 ( iod9e 9 #a gr4 potas4 iodide40 ,iodum-,mill] is a heavy1 d>k liquid hav+ an odor *>act]i/ic ( e!r 7e?yl oxid74 ,qualitative te/s reveal$ ! pres5ce ( glyc]91 free iod91 iodid & potassium4 ,! specific gravity at #be degrees 0 #a4bhd4 ,direct titration ) sodium ?iosulphate solution indicat$ ! pres5ce ( #a4fh p] c5t4 ( free iod94 ,a det]m9ation ( ! total iod9 cont5t by ! ,hunt] me?od indicat$ #c4jf p] c5t4 ,subtraction ( ! am\nt ( free iod9 f\nd f ! total am\nt ( iod9 pres5t1 gives #a4ch p] c5t4 comb9$ iod94 ,assum+ ?is to be pres5t z potassium iodid1 z appe>s probable f ! qualitative exam9ation & f ! quantitative det]m9ation ( potassium1 #a4hj p] c5t4 potassium iodid is indicat$4 ,f ?is exam9ation x is conclud$ t ,iodum-,mill] is1 ess5tially1 a solution ( iod9 & potassium iodid 9 glyc]91 conta9+ #a4fh p] c5t4 free iod9 & #a4hj p] c5t4 potassium iodid4 ,! exam9ation contradicts ! assumption t ,iodum-,mill] is ei!r novel 9 pr9ciple or new4 ,moreov]1 accept+ ! firm's /atem5t t #de drops weigh #a dram 7#fj gra9s7 ! exam9ation %[s t "o drop equals n 8! p] c5t4 ( iod9e 9 #a gr4 potas4 iodide0 b in/ead1 ! p] c5t4 ( iod9 9 only #a_/bj gra9 potassium iodid4 ,z ! /atem5t t 8,ea* drop equals ! p] c5t4 ( iod9e 9 #a gr4 potas4 iodide0 appe>s on ! label ( ! trade package1 ,iodum-,mill] w\ld seem to be misbr&$ "u ! f$]al ,food & ,drugs ,act4 ,! recomm5d$ int]nal dosage ( ,iodum-,mill] 7f #a_/b to #bj drops7 is equival5t to f #a_/dj to #a gra9 ( potassium iodid4 ,its ext]nal efficacy 9 comp>ison ) t ( o!r iod9 prep>ations may be e/imat$ by comp>+ ! respective free iod9 cont5ts1 s9ce ! g]micidal p[] ( comb9$ iodid is negligible4 ,:ile ,iodum-,mill] conta9s #b4ae gm4 free iod9 9 #ajj c4c41 t9cture ( iod9 conta9s #g gm4 p] #ajj c4c4 & comp\nd solution ( iod9 7,lugol's solution7 conta9s #e gm4 free iod9 9 #ajj gm4 ,among ! adv]tis+ lit]ature is a circul> :i* purports to be a 8,c]tificate f ,kansas ,city ,te/+ ,laboratory1 by ,roy ,cross1 ,secret>y40 ,! 8c]tificate0 attempts to prove t ,iodum-,mill] is va/ly sup]ior to ! (ficial t9cture ( iod9 z a g]micide1 ass]t+ t 8,9 ! process ( dissolv+ t9cture ( iod9 9 wat]1 a v l>ge am\nt ( ! iod9 is lo/ by precipitation44440 ,?is is n true ( ! t9cture ( iod9 :i* is n[ (ficial1 ?\gh x is true ( ! t9cture (ficial 9 =m] editions ( ! ,ph>macopeia4 ,! report ignores completely ! widely us$ aque\s solution ( iod94 ,iod-,izd-,oil 7,mill]'s7 is said to be an 8,iod9e ,comb9ation0 made 8f ! same ,soluble ,soot ,iod9e z is ,,iodum-,,mill]40 ,x is said to 8lib]ate ,free ,soluble ,iod9e0 :5 appli$ to ! sk91 muc\s surfaces1 etc4 ,x is fur!r def9$ z 8,soluble ,iod9e comb9$ ) wat]-:ite ,hydroc>bon ,oil0 & is said to lib]ate 8,soluble ,iod9e #b p] c5t40 ,:ile ^! /atem5ts sugge/ t ,iod-,izd-,oil 7,mill]'s7 conta9s ! iod9-potassium iodid comb9ation conta9$ 9 ,iodum-,mill]1 analysis indicat$ ! oil to be a simple solution ( iod9 9 liquid petrolatum4 ,quantitative det]m9ations indicat$1 n #b p] c5t4 ( iod91 z claim$1 b only #j4db p] c5t4 & all ( ?is 0 pres5t z free iod94 ,,ref]ee',s ,,report ,! foll[+ !rapeutic claims appe> on ! label ( a bottle ( ,iodum-,mill]3 8,,ext]nal ,,indications 8,tub]culosis1 ,pneumonia1 ,pleurisy1 ,c\gh1 ,sore ,?roat1 ,pyorrhea1 ,tonsilitis1 ,rheumatism1 ,sp9al ,irritation1 ,boils1 ,felons or any ,pa94 ,p]io/itis1 ,c>buncles1 ,fi/ula 9 ,ano1 ,goit]1 ,blood ,poison1 ,diseases ( ,ut]us & app5dages 7apply full /r5g? on cotton wrapp$ applicator71 ,gonorrhea1 acute or *ronic 9 bo? sexes1 ,or*itis1 ,bubo1 ,pro/atitis1 ,swell+s1 ,enl>g$ ,gl&s1 ,etc40 8,,int]nal ,,indications 8,pneumonia1 ,tub]culosis1 ,pleurisy1 ,typhoid ,fev]1 ,syphilis1 ,cat>rh ( ,muc\s surface ( ,alim5t>y ,canal1 ,autotoxemia1 ,vomit+ ( ,pregnancy1 ,rheumatism1 ,*ronic ,gl&ul> & ,organic ,affections40 ,! 8c]tificate0 f ! ,kansas ,city ,te/+ ,laboratory1 m5tion$ above1 /ates t ,iodum-,mill] 0 f\nd to h a g]micidal value n9ete5 times great] ?an c>bolic acid--a some:at rem>kable f9d+ 9 view ( ! fact t iod9 dissolv$ by means ( potassium iodid 9 alcohol or wat]1 :5 tri$ on ! typhoid bacillus has rec5tly be5 f\nd to possess only f\r times ! g]micidal value ( c>bolic acid 9 a solution ( ! same /r5g? 7,mab5 & ,:ite3 ,*em4 & ,drug41 ,jan4 #cj1 #aiae1 p4 #add74 ,! 8c]tificate0 fur!r /ates t ! te/ 8%[s available iod9e z f\nd 9 ,,iodum-,,mill] to h ! greate/ bact]icidal p[] ( any sub/ance t we h ev] te/$ t c be us$ m$ic9ally40 ,!re is no reason to believe t ! desire to please its patrons has l$ ! 8te/+ laboratory0 a/ray f ! lit]al tru?4 ,! laboratory's exp]i5ce may be limit$ & ! /atem5t !re=e entirely correct z f> z x goes4 ,no m5tion1 h[ev]1 is made ( any te/s comp>+ ! g]m-de/roy+ p[] ( ,iodum-,mill] ) t ( t9cture ( iod91 :i* conta9s #g p] c5t4 free iod91 unless ! casual /atem5t t 8,iodum-,mill] /]iliz$ ! sk9 m quickly0 ?an t9cture ( iod91 be tak5 to imply su* te/s4 ,x is n cle>1 h[ev]1 by :at means ! laboratory 0 able to det]m9e t !re 7 no bact]ia left alive 9 ! sk9 aft] application ( t9cture ( iod9 & ,iodum-,mill]2 no details are giv5 ( ! me?ods us$ 9 arriv+ at ?is conclusion4 ,a circul> says t ,iodum-,mill] 8444 gives ! ,greate/ ,bact]icidal & ,!rapeutic ,action1 :e!r us$ ,int]nally1 ,ext]nally1 ,hypod]mically or ,intrav5\sly40 ,9 ! light ( ! prec$+ report ( ! ,*emical ,laboratory ( ! ,association1 ^! claims require little comm5t4 ,! laboratory has %[n t ! free iod9 cont5t 7& consequ5tly ! g]micidal effici5cy7 ( ,iodum-,mill] is less ?an half t ( ,lugol's solution1 & less ?an a ?ird ( t ( ! (ficial t9cture ( iod94 ,z = ! advice to use ,iodum-,mill] int]nally 9 diseases rang+ f pneumonia to syphilis & f typhoid to tub]culosis1 9 ord] to be conv9c$ ( its dang]\s "*1 x is necess>y only to recall t ?is treatm5t is equival5t to ! adm9i/ration ( small doses ( iodid--f #a_/dj to #a gra9 ( potassium iodid4 ,! my/]y be+ remov$ f ! composition ( ,iodum-,mill]1 ! absurd extravagance ( ! claims made = x becomes manife/4 ,! criticisms ( ! ,c\ncil on ! recomm5dations = ,burnham's ,soluble ,iod9e 7,! ,j\rnal ,a4 ,m4 ,a41 ,may #ae1 #aiae1 p4 #afgc7 apply 9 almo/ e p>ticul> to ,iodum-,mill]4 ,unw>rant$ !rapeutic claims are made = ,iodum-,mill]2 incorrect /atem5ts are made ) reg>d to its composition & t ( ,iod-,izd-,oil 7,mill]'s72 & ! application ( a trade "n to bo? ( ^! products is unju/ifiable1 s9ce nei!r is orig9al4 ,x is !re=e recomm5d$ t ,iodum-,mill] & ,iod-,izd-,oil 7,mill]'s7 be held ineligible = ,new & ,non(ficial ,rem$ies--7,ab/ract$ 9 ,! ,j\rnal ,a4 ,m4 ,a41 ,oct4 #b1 #aiae47 ,,elixir ,,iodo-,,bromide ,,( ,,calcium ,,comp4 8,,)\t ,,m]cury0 ,,& 8,,) ,,m]cury0 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,tild5 ,company1 ,new ,lebanon1 ,n4 ,y41 & ,/4 ,l\is1 ,mo41 sells 8,elixir ,iodo-,bromide ( ,calcium ,comp4 )\t ,m]cury0 & 8,elixir ,iodo-,bromide ( ,calcium ,comp4 ) ,m]cury40 ,! latt] is said to conta91 9 addition to ! +r$i5ts ( ! =m]1 #a_/ajj gra9 m]curic *lorid 9 ea* fluidram4 ,accord+ to ! label ! =mula ( ! elixir 8)\t m]cury0 is3 8,=mula--,salts ( ,iod9e1 ,brom9e1 ,potassium1 ,sodium1 ,calcium1 ,magnesium ) ,/ill+ia1 ,s>sap>illa1 ,rumex1 ,dulcam>a1 ,lappa1 ,t>axacum1 ,m5isp]mum40 ,a rec5t circul> decl>es t ! elixir conta9s3 8444 a numb] ( ! mo/ p[]ful alt]atives ( ! ph>macopeia su* z *emically pure iod91 magnesium1 potassium ) s>sap>illa1 /ill+ia1 prickly a%1 burdock1 t>axacum1 etc4 444 ,ea* fluid\nce conta9s sev5ty-two gra9s ( ! comb9$ salts40 ,! same circul> also alleges t ea* dram ( ! prep>ation conta9s3 8444 ! equival5t ( "o & "o-half gra9s ( ! comb9$ iodids1 potassium & calcium 4440 ,x w be obs]v$ t1 7#a7 ! two /atem5ts quot$ f ! circul> make no ref]5ce to bromids2 7#b7 ! /atem5t t ea* dram conta9s 8! equival5t0 ( #a-a_/b gra9s ( ! comb9$ iodids1 potassium & calcium1 acc\nts = b #ab ( ! #gb gra9s ( 8! comb9$ salts0 p] fluid\nce decl>$ 9 ! prec$+ quotation2 7#c7 ! circul> m5tions ! pres5ce ( a drug--prickly a%--n decl>$ on ! label &1 f9ally 7#d7 none ( ! 8=mulas0 gives ! quantities ( all ( ! sev]al con/itu5ts4 ,x is evid5t f ^! 8=mulas0 t ! ,tild5 ,company cont9ues its policy ( concealm5t & my/ification z exemplifi$ 9 ! cases ( ,hydrocyanate ( ,iron1 ,tild5 7discuss$ 9 ,! ,j\rnal1 ,june #ai1 #aiji1 p4 #bjjh71 ,febrisol 7,! ,j\rnal1 ,june #bi1 #aiab1 p4 #bjdc7 & ,respirazone 7,! ,j\rnal1 ,june #ad1 #aiac1 p4 #ahii74 ,9 ! circul> j quot$ 78,! ,conque/ ( ,syphilis071 all hope = ! syphilitic is decl>$ to re/ 9 m]cury & iod91 & x is impli$ t only ?r\gh ,elixir ,iodo-,bromide ( ,calcium ,comp4 is x possible to obta9 ! greate/ good f ^! drugs4 8,7 ! cleans+ influ5ces ( ^! two drugs m]cury & iod9 unavailable to ! luetic pati5t1 he1 truly1 w\ld be z pitiable an object z ! lep] 444 8,mod]n ,ph>macy has devis$ no bett] means ( utiliz+ ^! anti-syphilitics ?an ,elixir ,iodo-,bromide ( ,calcium ,comp4 7,tild57 ) or )\t m]cury4444 ,! ,elixir1 9 prop] dosage1 acts 9 specific fa%ion & is adapt$ = use 9 all /ages ( ! disease4 8,9 ! e>ly mon?s 444 ,elixir ,iodo-,bromide ( ,calcium ,comp4 7,tild57 ) m]cury is a tru/wor?y weapon & ! physician ne$ h no fe> b t x w subjugate ! disease 444 8,:5 444 ! virul5t /age is pass$ 444 ,elixir ,iodo-,bromide ( ,calcium ,comp4 7,tild57 )\t m]cury may be giv5 ! pati5t ) e assurance t m$ic9e's mo/ aggressive measures are be+ resort$ to 444 ,f "t to "t1 up to ! v end ( ! "t honor$ ?ree ye>s' p]iod ( treatm5t1 x is well to put ! pati5t back on ! bi*loride1 us+ = ?is purpose ! =m ( ! ,elixir adm9i/]$ 9 ! fir/ /ages ( ! disease 444 8,?is regime 444 w indubitably antidote ! virus ( syphilis & eradicate f ! organism its e ve/ige40 ,:ile x seems incr$ible t any physician w\ld jeop>dize ! heal?--ev5 ! life--( a pati5t by accept+ ?is boa/ful magniloqu5ce z s\nd !rapeutic advice1 /ill ! fact t c]ta9 m$ical j\rnals l5d _! adv]tis+ pages to adv]tisem5ts = ,tild5's ,elixir ) ! caption 8,! ,conque/ ( ,syphilis0 makes x incumb5t on ! ,c\ncil to record its condemnation ( ! employm5t ( ?is unsci5tific1 semisecret mixture4 ,x is recomm5d$ t ,elixir ,iodo-,bromide ( ,calcium ,comp4 8)\t m]cury0 & 8) m]cury0 be held 9 conflict ) ,rule #a 7secrecy ( composition71 ,rule #f 7unw>rant$ !rapeutic claims7 & ,rule #aj 7unsci5tific composition74--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #f1 #aiae47 ,,leci?9 ,,prep>ations ,,omitt$ ,,f ,n4 ,n4 ,r4 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! foll[+ report 0 s5t to ! manufactur]s ( ! v>i\s leci?9 prep>ations m5tion$ !re94 ,z ! replies ( ! manufactur]s 7 obvi\sly writt5 f ! comm]cial po9t ( view & did n affect ! ,c\ncil's conclusion t leci?91 :5 indicat$1 w\ld be giv5 m advantage\sly 9 ! =m ( yolk ( egg ?an 9 ! less pure manufactur$ product1 ! ,c\ncil direct$ t ! report be publi%$1 toge!r ) extracts f ! replies ( ! manufactur]s4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,comm]cial leci?9 prep>ations are at be/ v impure sub/ances2 all are m or less alt]$ f ! orig9al composition4 ,ev5 ) great c>e1 ! me?ods ( extraction & dry+ always produce consid]able decomposition2 & 9 "s cases ! phosphorus & nitrog5 cont5ts be> b little relation to ! !oretical values4 7,long1 ,j4 ,h43 ,j\r4 ,am4 ,*em4 ,soc41 xxx1 #hha4 ,mc,lean1 ,hugh3 ,*em4 ,ab/racts1 ,may #bj1 #aiae74 ,!re is n ! slighte/ reliable evid5ce t comm]cial leci?9 has any advantage ov] ! leci?9 conta9$ 9 natural foods2 ! weight ( probability is on ! o!r side4 ,! doses recomm5d$1 moreov]1 are absurdly small2 & ! am\nt ?us adm9i/]$ is )\t practical value4 ,:y adm9i/] a few milligrams ( a m or less decompos$ leci?9 :5 x is possible to give a f> l>g] weight ( a pur] sub/ance 9 ! =m ( yolk ( egg8 ,9 view ( ^! consid]ations ! ,c\ncil vot$ t ! foll[+ propriet>y products be omitt$ f ! next edition ( ,n4 ,n4 ,r43 ,glyc]ole ( ,leci?9 ,lecibr9 ,leci?9 ,solution ,leci?ol ,neuro-,leci?9-,abbott & t ! g5]al article on 8,leci?9 ,prep>ations0 be transf]r$ to ! annual ,c\ncil ,reports z a matt] ( record4 ,! report 0 submitt$ to ! manufactur]s4 ,_! replies 7 evid5tly bas$ on comm]cial consid]ation1 & call$ = no modification 9 ! report4 ,! ref]ee recomm5d$ t ! prec$+ report be publi%$ toge!r ) ! foll[+ extracts f ! replies ( ! manufactur]s3 ,f ,arm\r & ,company3 8,we are sell+ a good deal ( ,leci?ol & x seems to be giv+ satisfactory results 9 "s qu>t]s4444 ,we %all cont9ue to adv]tise ,leci?ol along ! l9es we h employ$ h]et(ore40 ,f ! ,abbott ,laboratories3 8,we c assure y ( our confid5ce 9 ! !rapeutic value ( ,neuro-,leci?94 ,?is has be5 atte/$ by ! reports ( favorable results s5t u by _m physicians1 z well z by ! p]iodical lit]ature ( ! la/ few ye>s :i* conta9s a consid]able numb] ( v enc\rag+ ref]5ces to leci?9 !rapy40 ,f ,fair*ild ,bros4 ,fo/]3 8,we w\ld l simply to say t ! physician & ! ,c\ncil mu/ be aw>e ( ! circum/ances & ! purposes :i* actuat$ u 9 plac+ leci?9 at disposal1 viz41 ! /udies--rese>*--( leci?9 & ! prop]ties attribut$ to x & :i* l$ to inquiry = & consid]ation ( x4 ,! quantities propos$ = m$ic9al use 7 n sugge/$ by u2 ! sugge/ion ( leci?9 9 small quantities z a !rapeutic ag5t 0 obvi\sly direct$ by ^? :o propos$ x4444 ,! "q :e!r leci?91 p] se1 has !rapeutic prop]ties 9 contra/ to leci?9 z naturally conta9$ 9 food sub/ances1 is some?+ we d n und]take to decide4 ,! ,c\ncil1 on purely !oretical gr\nds1 decides 9 ! negative not)/&+ cl9ical exp]i5ce--int]nal & hypod]mic--& ?us w\ld d5y leci?9 ! /atus ( a new & non(ficial rem$y1 wor?y ( at lea/ t5tative progressive cl9ical consid]ation4 ,we c only say t we (f]$ bona fide leci?9 & t we did n make ! inve/igation ( leci?9 a pretext = ! sale ( all sorts ( leci?9 #8jumbles' ) leci?9 9 small proportions1 tak+ _! "n & mak+ _! bid on leci?940 ,bel[ appe>s ! g5]al article :i* has be5 omitt$ f ,n4 ,n4 ,r43 ,leci?9 ,prep>ations ,leci?9s are fat-l bodies belong+ to ! gr\p ( phosphatides4 ,!y all consi/ ( glyc]yl e/]s conta9+ two fatty acid radicals & ! phosphoric acid radical 9 :i* "o ( ! residual hydrog5s is replac$ by ! *ol9e gr\p4 ,! fatty acid may be palmitic1 oleic or /e>ic & v>i\s comb9ations are kn[n to exi/2 = example1 di/e>yl leci?91 /e>yl palmityl leci?9 & s on4 ,! comm]cial leci?9s usually include ! closely relat$ kephal9s4 ,on saponification ! leci?9s split m or less readily into *ol9e1 ! fatty acids & glyc]ophosphoric acid1 & by fusion ) alkali nitrate & c>bonate !y yield alkali phosphate4 ,!y occur1 free or 9 comb9ation z leci?oprote9s1 mo/ abundantly 9 c]ta9 animal tissues1 b !re are also vegetable leci?9s4 ,! leci?9s ( comm]ce are obta9$ usually f yolks ( eggs or f calves' or %eep's bra9s4 ,num]\s processes h be5 devis$ = ! prep>ation ( leci?9 f egg-yolk or animal tissue4 ,f egg-yolk x may be obta9$ by mak+ an alcoholic extract & precipitat+ by cadmium *loride4 ,! precipitate is wa%$ ) alcohol & e!r1 mix$ ) #hj p] c5t4 alcohol & w>m$ ) ! prop] am\nt ( ammonium c>bonate to remove ! cadmium4 ,aft] filt]+ hot & conc5trat+ ! filtrate ! leci?9 is ?r[n d[n by cool+ to a l[ temp]ature--#aj ,c4 or bel[4 ,! precipitate is tak5 up 9 *lor(orm & reprecipitat$ by acetone4 ,f tissues x is obta9$ by extract+ ) w>m alcohol & e!r1 conc5trat+ ! extract1 precipitat+ ) acetone & repeat+ ! op]ations4 ,pure leci?9 is :ite1 b ! comm]cial prep>ations are yell[i%-br[n wax-l solids1 :i* are n soluble 9 wat] b =m milky emulsions :i* exhibit ! myel9e figures "u ! microscope4 ,! solubility 9 cold alcohol or e!r is slight1 b heat aids x4 ,leci?9s are n soluble 9 acetone4 ,!y are hygroscopic & ! wat] mixtures und]go decomposition on /&+4 ,!y d>k5 on exposure to air & light4 ,! alcoholic solution is precipitat$ by plat9um or cadmium *loride4 ,x is decompos$ by alkalies ) ! =mation ( *ol9e & trime?ylam9e4 ,! a% conta9s phosphoric acid4 ,! diff]5t leci?9s conta9 f #c4hd to #d4ab p] c5t4 ( phosphorus & #a4gc to #a4hf p] c5t4 ( nitrog54 ,! ratio ( nitrog5 to phosphorus %\ld be at #a to #b4ba4 ,leci?9 is incompatible ) alkalies2 x %\ld be kept 9 well-/opp]$ bottles & %\ld be protect$ f ! light4 ,! cont5t ( leci?9 7plus kephal97 9 tissues is ab\t z foll[s3 ,p] ,c5t4 ,egg-yolk #h to #ab ,egg-:ite #j4a to #j4b ,liv] #b4j to #c4j ,kidney #b4j to #c4f ,lung #b4j to #c4j ,pancreas #b4j to #c4j ,actions & ,uses4--,! leci?9 prep>ations h be5 recomm5d$ 9 _m pa?ologic conditions1 especially 9 malnutrition & sexual debility4 ,mod]ate doses are said to br+ ab\t a m>k$ ret5tion ( nitrog5 & phosphorus1 b satisfactory pro( ( ?is is lack+4 ,x is extremely unlikely t ! small doses :i* h be5 recomm5d$ 9 pill or tablet =m or 9 emulsions c h any p]ceptible action1 9 view ( ! fact t _m ( our natural foods conta9 mu* great] weights ( available leci?9s ?an ! m$ic9al doses provide4 ,!re is no good basis = ! /atem5t t ! free leci?9 has a great] food value or is m readily assimilat$ ?an is ! sub/ance z f\nd 9 eggs or tissue4 ,! rev]se proposition is mu* m likely to be true1 especially :5 x is consid]$ t ! comm]cial prep>ations are usually some:at alt]$ or decompos$ 9 ! process ( sep>ation4 ,dosage4--,giv5 by ! m\? 9 ! =m ( pills1 tablets or glyc]o-alcoholic emulsions4 ,! am\nt ( actual leci?9 +e/$ 9 ?is way is usually small because ( ! d\btful purity ( ! orig9al prep>ation4 ,sev]al doses1 z commonly adm9i/]$1 w\ld be requir$ to furni% ! am\nt ( leci?9 pres5t 9 a small egg4--7,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiae1 p4 #abb47 ,,propriet>y ,,names ,,= ,,liquid ,,petrolatum ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has accept$ ! foll[+ report & au?oriz$ its publication4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,a =m] report ( ! ,c\ncil 7,liquid ,petrolatum or 8,russian ,m9]al ,oil10 ,report ,c\ncil ,ph>m4 & ,*em41 ,! ,j\rnal1 ,may #cj1 #aiad1 p4 #agdj7 call$ att5tion to ! l>ge numb] ( conc]ns t 7 plac+ on ! m>ket liquid petrolatum z a propriet>y "u co9$ names4 ,s9ce !n ! numb] ( su* products has increas$4 ,! ,c\ncil has be5 reque/$ by sev]al conc]ns to consid] _! products put out "u propriet>y br& names4 ,! rules ( ! ,c\ncil affirm t 8! application ( #8trade names' to (ficial or e/abli%$ nonpropriet>y sub/ances t5ds to confusion & fo/]s _m abuses40 ,9 accordance ) ?is g5]al rul+1 ! ,c\ncil has inv>iably refus$ to c\nt5ance propriet>y names appli$ to liquid petrolatum4 ,! ,c\ncil holds t propriet>y or co9$ names = ?is sub/ance are detrim5tal to m$ical progress1 s9ce !y are sure to fo/] ! impression t ! p>ticul> product is diff]5t f liquid petrolatum4 ,manufactur]s h be5 advis$ t !re is no objection to di/+ui%+ _! products by ! addition ( _! firm "n or ! initial repres5t+ ! firm "n2 = in/ance1 8,liquid ,petrolatum1 ,a4 ,b4 & ,co40 or 8,liquid ,petrolatum1 ,smi?40 ,! ,c\ncil also believes t su* designations z 8,/> ,liquid ,petrolatum0 or 8,liquid ,petrolatum1 ,an*or ,br&10 may be reg>d$ z unobjectionable1 provid$ t ! words 8,liquid ,petrolatum0 are always us$ 9 connection ) ! br& designation & giv5 equal prom95ce4--7,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiae1 p4 #abg47 ,,s5g ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has adopt$ ! foll[+ report & au?oriz$ its publication4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,s5g 7,sultan ,drug ,co41 ,/4 ,l\is7 is call$ by ! manufactur]s3 8444 a palatable prep>ation ( ,panax 7,g9s5g7 9 an aromatic vehicle40 ,reg>d+ g9s5g 7,panax qu9quefolia7 ! ,unit$ ,/ates ,disp5satory1 n9ete5? edition1 page #afjc1 says3 8,! extraord9>y m$ic9al virtues =m]ly ascrib$ to g9s5g _h no o!r exi/5ce ?an 9 ! imag9ation ( ! ,*9ese4 ,x is little m ?an a demulc5t1 & 9 ?is c\ntry is n employ$ z a m$ic9e40 ,no discussion ( g9s5g is to be f\nd 9 ! m rec5tly publi%$ books on ph>macology1 mat]ia m$ica & !rapeutics1 evid5tly because _! au?ors agree ) ?is e/imate4 ,on ! o!r h&1 physicians are told ?r\gh ! m$ium ( adv]tisem5ts appe>+ 9 m$ical j\rnals t ,s5g is3 8,an effici5t rem$y 9 all affections 9 :i* ! ga/ro-inte/9al gl&s ne$ /imulat+4 8,exceptionally useful 9 atonic indige/ion1 malnutrition1 convalesc5ce f ! acute diseases1 & all dige/ive disord]s *>act]iz$ by d]ang$ or depress$ functions40 7,woman's ,m$ical ,j\rnal1 ,july1 #aiad47 ,accord+ to ! label1 ,s5g is indicat$ 9 8indige/ion10 8malassimilation10 8malnutrition0 & 8wa/+ diseases40 ,x is also /at$--?\gh ! prep>ation is admitt$ to conta9 #ah p] c5t4 ( alcohol--t to give babies 8t5 to fifte5 drops 9 wat] or milk dur+ fe$+0 is a prop] proc$ure & t 8,= ,colic1 ,flatul5cy1 etc41 ! dose = an adult or *ild may be repeat$ e half h\r until reliev$40 ,! foll[+ are "s ( ! exagg]at$ !rapeutic claims made = ?is prep>ation ( a wor?less drug3 8,z a result ( its adm9i/ration ! ga/ro-inte/9al secretions are augm5t$1 ! dige/ion ( food is sub/antially increas$1 & f]m5tative processes are promptly ov]come40 8,s5g w specifically enc\rage ! secretion ( ! juices 9 ! entire alim5t>y tract 4440 ,! =mula furni%$ = ,s5g is non-quantitative & !re=e mean+less4 ,! prep>ation is exploit$ 9 a mann] to enc\rage its ill-advis$ use by ! public1 & exagg]at$ & unw>rant$ !rapeutic claims are made = x4 ,! use ( an ineffici5t or wor?less drug l g9s5g1 moreov]1 is detrim5tal to rational !rapeutics4 ,! ,c\ncil !re=e vot$ t ,s5g be refus$ recognition = conflict ) ,rules #a1 #d1 #f & #aj4--7;,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiae1 p4 #abi47 ,,fros/',s ,,blaud ,,capsules ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,fros/'s ,blaud ,capsules & ,fros/'s ,blaud1 ,ars5ic & ,/ry*n9e ,capsules 7 submitt$ to ! ,c\ncil by ,c4 ,e4 ,fros/ ,co41 ,montreal1 ,canada4 ,?is firm claims1 on ! au?ority ( ! report ( a firm ( analytical *emi/s1 t3 8444 ( ?ree lead+ ,blaud prep>ations b\ght by u on ! op5 m>ket1 ! iron 9 ,fros/'s ,blaud ,capsules %[$ ! highe/ p]c5tage ( ,f]r\s c>bonate40 ,! ,*emical ,laboratory ( ! ,am]ican ,m$ical ,association f\nd ?is claim unju/ifi$4 ,! laboratory report$ t !re 0 no especial diff]5ce 9 ! f]r\s iron cont5t ( ! v>i\s ,blaud pills f\nd on ! m>ket1 & t among t5 specim5s exam9$1 ! total iron cont5t 0 ! l[e/ 9 ! ,fros/ specim54 ,9 view ( ?is ! ,c\ncil refus$ recognition to ,fros/'s ,blaud ,capsules & ,fros/'s ,blaud1 ,ars5ic & ,/ry*n9e ,capsules4--7,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiae1 p4 #afd47 ,,tyree',s ,,elixir ,,( ,,bu*u ,,& ,,hyoscyamus ,,comp\nd ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,ea* dess]tspoonful ( ?is prep>ation is said to repres5t ,bu*u ,leaves #c-a_/b gra9s ,uva ,ursi #a-a_/h gra9s ,p>eira ,brava #a-a_/h gra9s ,hyoscyamus #a-a_/b gra9s ,hops #a-a_/b gra9s ,acetate ,pota% #g-a_/b gra9s ,spirits ,nitre #e gra9s ,alcohol #e p] c5t4 7by volume70 ,! manufactur]1 ,j4 ,s4 ,tyree1 ,wa%+ton1 ,d4 ,c41 (f]s ?is =mula to ! m$ical pr(ession ) ! foll[+ claim3 8,approximate composition made sic by quantitative & qualitative analysis ( ! f9i%$ product40 ,x is also claim$ t 8,an ev5 great] advantage ( ,tyree's ,bu*u & ,hyoscyamus ,comp\nd ov] o!r drugs1 lies 9 ! fact t e con/itu5t ( ! =m] is requir$ to con=m to a fix$ /&>d ( active pr9ciple /r5g?2 h5ce ! results d]ivable f x are absolutely uni=m40 ,^! pret5ti\s claims ( sci5tific accuracy look r absurd to *emi/s4 ,_m ( ! sub/ances pres5t 9 bu*u1 hops1 hyoscyamus1 uva ursi & p>eira brava are also pres5t 9 o!r drugs2 h5ce x w\ld nev] occur to a ph>maceutical *emi/ to try to asc]ta9 ! composition ( su* a mixture z ,tyree's ,elixir by 8quantitative & qualitative analysis ( ! f9i%$ product10 mu* less to det]m9e ! 8active pr9ciple /r5g?0 ( ea* +r$i5t1 = no me?ods are kn[n by :i* ?is c be done4 ,x is claim$ t1 because ( ! c>e ex]cis$ 9 mak+ ,tyree's ,elixir 8444 ! results d]ivable f x are absolutely uni=m40 ,a mom5t's reflection1 h[ev]1 mu/ compel any physician to attribute ?is /atem5t1 on ! mo/ *>itable con/ruction1 to %e] ignorance4 ,( c\rse1 ev5 a def9ite *emical pr9ciple1 su* z qu991 does n ex]t uni=m cl9ical action1 = cl9ical conditions v>y1 & accord+ly ! pati5t may or may n be cur$4 ,x is simply prepo/]\s to claim t ! cl9ical results obta9$ f su* sub/ances z hops1 p>eira brava1 bu*u & uva ursi are absolutely uni=m4 ,a peculi>ly vici\s claim is t ! elixir r5d]s ! muc\s surfaces ( ! g5ito-ur9>y tract 8ho/ile to ! multiplication ( ! gonococci40 ,s9ce infection ) ! gonococcus produces ! dire/ results1 any claim :i* means 9 pla9 ,engli% t ! rem$y assi/s 9 produc+ a cure or 9 prev5t+ infection ) t organism _c be condemn$ too /rongly4 ,uva ursi1 to be sure1 has "s slight antiseptic action b x is devoid ( any curative action 9 gonorrhea & ! m9ute am\nts t are pres5t 9 ! ,tyree elixir are ( no m protective value aga9/ gonorrheal infection ?an a gra9 ( hexame?yl5am9 w\ld be4 ,x is fur!r claim$ t ! elixir is a 8specific0 = 8,inflammation ( ! ,bladd]1 ,bright's ,disease1 ,r5al ,colic1 ,suppurative ,nephritis1 ,acute ,cy/itis1 ,ure?ritis1 ,cat>rh ( ! ,bladd] x w\ld be int]e/+ to "k :at di/9ction ! manufactur] draws betwe5 #8,inflammation ( ! ,bladd]1' #8,cy/itis' & #8,cat>rh ( ! ,bladd]'1 ,acidemia1 ,edema1 ,vesical ,cat>rh ( ,old ,age1 ,li!mia0 & t ascites & anas>ca 8c be r$uc$ greatly to ! satisfaction ( ! pati5t1 & honor ( ! physician0 by us+ a mixture ( ,tyree's ,elixir & infusion ( digitalis4 ,su* claims z ^! d n m]it s]i\s discussion1 = !y c>ry _! own refutation4 ,x is recomm5d$ t ,tyree's ,elixir ( ,bu*u & ,hyoscyamus ,comp\nd be held 9 conflict ) ,rules #e1 #f & #aj & t publication ( ?is report be au?oriz$4--7,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiae1 p4 #afg47 ,,hydrole9e ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,hydrole9e 7,*>les ,n4 ,critt5ton ,company1 ,new ,york7 is a cod liv] oil emulsion said to conta9 #de p] c5t4 ( cod liv] oil1 a trace ( salicylic acid & #ah-a_/b gra9s ( 8,pancreat91 ,etc410 p] ounce4 ,! adv]tis+ claims are bas$ l>gely on ! !ory t cod liv] oil is 8t p>ticul> fat :i* dietetic exp]i5ce & physiological *emi/ry h prov$ to be mo/ dige/ible40 ,z a matt] ( fact1 :ile ! sup]ior dige/ibility ( cod liv] oil ov] o!r oils has (t5 be5 ass]t$1 nei!r 8dietetic exp]i5ce0 nor 8physiological *emi/ry0 h 8prov$0 ?is by def9ite obs]vations4 ,! ,critt5ton ,company claims t x is m readily split ?an o!r oils4 ,?is is probably n true1 easy emulsification ( ! raw oil be+ (t5 conf\nd$ ) easy splitt+4 ,?is latt] claim1 h[ev]1 is (f]$ 9 ju/ification ( ! "n 8,hydrole9e10 :i* ! ,critt5ton ,company int]prets z 8hydrat$ oil40 ,a circul> wrapp$ ar\nd ! bottle conta9s ! ass]tion t 8,cod ,liv] ,oil has long be5 held 9 high e/eem by ! m$ical pr(ession = ! treatm5t ( a l>ge numb] ( s]i\s diseases40 ,?is recomm5dation is likely to lead ! public to place undue reliance on ,hydrole9e 9 ! grave conditions m5tion$4 ,! prep>ation is 9 conflict ) ! rules ( ! ,c\ncil inasmu* z its "n does n indicate its composition1 unw>rant$ !rapeutic claims are made = x1 & ! exploitation is likely to give ! public unw>rant$ confid5ce 9 its value4 ,! ,c\ncil !re=e held ,hydrole9e ineligible = ,new & ,non(ficial ,rem$ies4--7,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiae1 p4 #aga47 ,,curative ,,vacc9e1 ,,brus*ett9i ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,curative ,vacc9e1 ,brus*ett9i1 manufactur$ by ,a4 ,brus*ett9i1 ,g5oa1 ,italy1 is claim$ to h ! prop]ties 8( act+ directly on ! tub]cul> bacillus1 br++ directly into ! field & det]m9+ a hyp]production ( antibacill> & antitoxic sub/ances40 ,! use ( ! prep>ation is said to be indicat$ 9 8all =ms ( tub]culosis40 ,a ref]ee report$ to ! ,c\ncil t he _h exam9$ ! available in=mation & believ$ t ! use ( ?is product _h no satisfactory exp]im5tal basis4 ,! me?od ( prep>ation appe>s to be bas$ m on !oretical consid]ations ?an on exp]im5tal basis4 ,on ! recomm5dation ( ! ,committee on ,s]ums & ,vacc9es ! ,c\ncil vot$ t ,curative ,vacc9e1 ,brus*ett9i1 be n accept$ because 7#a7 ! me?od us$ = ! production ( ! vacc9e 0 n satisfactorily /at$2 7#b7 ! !ory on :i* its use is bas$ has n be5 satisfactorily confirm$1 & 7#c7 ! value ( ! product is n upheld by satisfactory cl9ical evid5ce4 ,! ,c\ncil's f9d+s1 9 accordance ) its proc$ure1 7 s5t to ! manufactur]s = comm5t4 ,8 reply 0 consid]$ by a new ref]ee :o f\nd t ! matt] pres5t$ did n w>rant a revision ( ! ,c\ncil's conclusions4 ,accord+ly ! ,c\ncil direct$ publication ( its f9d+s4--7,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiae1 p4 #agf47 ,,/e>ns' ,,w9e ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,fr$]ick ,/e>ns ,co4 m>ket a prep>ation kn[n z 8,/e>ns' ,w9e10 8,/e>ns' ,w9e ( ,cod ,liv] ,ext4 ) ,peptonate ( ,iron10 & z 8,v9um ,ext4 ,morrhuae1 ,/e>ns40 ,! con/itu5ts are said to be 8conc5trat$ extract ( fre% cod liv]s10 8,peptonate ( ,iron0 & a 8f9e quality ( prime ,%]ry ,w9e0 conta9+ #ah p] c5t4 ( alcohol4 ,?is prep>ation 0 at "o "t m>ket$ ?r\gh ! m$ical pr(ession1 b is n[ adv]tis$ direct to ! public 9 typical 8pat5t m$ic9e0 /yle4 ,! label on a rec5tly pur*as$ bottle ( ,/e>ns' ,w9e conta9s ! foll[+ /atem5ts3 8,,/e>ns ,,w9e is an ideal tonic = eld]ly p1 = weak1 pale & delicate *ildr5 & convalesc5ts4 8,,/e>ns ,,w9e has = _m ye>s be5 successfully prescrib$ 9 ! treatm5t ( g5]al or n]v\s exhau/ion1 anemia1 malnutrition1 loss ( appetite1 loss ( sleep1 faulty circulation & impov]i%$ blood supply40 ,! scope ( ! recomm5dations = ! prep>ation is fur!r indicat$ 9 a booklet accompany+ ! bottle1 :i* beg9s3 8,,/e>ns' ,,w9e1 ,:at ,x ,is & ,:y ,x ,is ,good = ,y40 ,! conclusion is3 8,,/e>ns' ,,w9e is a safe m$ic9e = ! "y1 middle-ag$ & old4 ,x is a safegu>d to ! family heal?40 ,x is n necess>y to discuss ei!r ^! all-embrac+ claims z to ! !rapeutic efficacy ( ! mixture or ! fallacies pres5t$ 9 favor ( cod-liv] extract & peptonate ( iron4 ,! ,c\ncil reaffirms ! op9ion t :atev] !rapeutic value cod liv] may h resides *iefly1 if n entirely1 9 its fatty con/itu5ts 7,! ,j\rnal1 ,oct4 #i1 #aiji2 ,reports ,c\ncil ,ph>m4 & ,*em41 #aiji1 p4 #aae74 ,a confirmation ( ?is op9ion has rec5tly be5 furni%$ by ! inve/igations ( ,pr(4 ,j4 ,p4 ,/reet 7,! ,j\rnal ,a4 ,m4 ,a41 ,feb4 #bj1 #aiae1 p4 #fch7 ( sev]al cod liv] cordials1 "o ( :i* 7,v9ol7 l ,/e>ns' ,w9e1 is describ$ z a w9e ( cod liv] extract ) peptonate ( iron4 ,/e>ns' ,w9e is ess5tially an alcoholic /imulant4 ,x is n 8a safe m$ic9e = ! "y1 middle-ag$ & old40 ,! unw>rant$ !rapeutic claims & ! recomm5dations = its indiscrim9ate use br+ x into conflict ) ,rules #d & #f4 ,! ,c\ncil vot$ t ,/e>ns' ,w9e be held ineligible = inclusion 9 ,n4 ,n4 ,r4--7,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiae1 p4 #agg47 ,,protonucle9 ,,& ,,protonucle9 ,,beta ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil _h adopt$ ! foll[+ report & au?oriz$ its publication4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,protonucle91 ) o!r products ( ,re$ & ,c>nrick1 0 exam9$ by ! ,c\ncil 9 #aijg & f\nd ineligible = admission to ,new & ,non(ficial ,rem$ies4 ,accord+ to ! pat5t specifications1 x is prep>$ 8f ! ?yroid & ?ymus gl&s1 bra9 7p9eal gl&s & pituit>y body71 bone-m>r[1 pancreas1 sple51 liv]1 saliv>y gl&s1 ,brunn]'s gl&s1 ,lieb]khn's follicles & peptic gl&s40 ,^! v>i\s gl&ul> bodies1 x is said1 are dri$ at a temp]ature bel[ #acj ,f4 7pref]ably betwe5 #ajj & #aaj72 ! fat is remov$ by e!r1 ! dri$ gl&s dis9tegrat$1 ! connective tissue remov$ by sift+ & ! result+ p[d] coat$ ) an e!r solution ( b5zo9 & mix$ ) milk sug>4 ,! dose is ?ree to t5 tablets 7#i to #cj gra9s7 daily4 ,protonucle9 ,beta is said to be produc$ by ! addition to ,protonucle9 ( an equal am\nt ( nucleoplasm & protoplasm ( ! sple54 ,! dose is f two cubes 7ea* #e gra9s7 ?ree times a day to ?ree cubes f\r times a day 7#cj to #fj gra9s daily74 ,special advantages ov] ord9>y nucle9 are attribut$ to ,protonucle91 9 :i*1 x is claim$1 c]ta9 unalt]$ cells rema9 t are m easily assimilat$ by ! leukocytes ?an are ord9>y prote9s1 ?us lead+ to a multiplication ( cells4 ,9 ! e>ly adv]tis+ ,protonucle9 0 claim$ to be3 8444 an exact physiological product d]iv$ f ! lymphoid /ructures ( ! body )\t ! use ( *emical ag5ts4444 ,s delicate is ,protonucle9 t any *emical ag5t is liable to di/urb its cellul> activity40 ,aft] its exam9ation ( ! product 9 #aijg 7,! ,j\rnal1 ,oct4 #e1 #aijg1 p4 #aaih71 ! ,c\ncil conclud$ t any di/9ction betwe5 ! action ( ,protonucle9 & t ( ord9>y nucle9 0 purely speculative & highly improbable4 8,if ! active +r$i5ts are really s un/able t !y are de/roy$ by all *emical ag5ts1 z claim$1 x seems impossible t ! activity w\ld be pres]v$ :5 ,protonucle9 is giv5 by m\? & !re=e subject$ to ! v pr(\nd *anges ( dige/ion40 ,at t "t ! importance ( ?yroid z an +r$i5t _h n be5 emphasiz$4 ,! foll[+ ye>1 h[ev]1 ,hunt & ,seidell 7,! ,j\rnal ,a4 ,m4 ,a41 ,oct4 #bd1 #aijh7 report$ ! results ( an inve/igation :i* %[$ t ,protonucle9 0 a dilut$ ?yroid prep>ation1 z skilfully disguis$ z 9 ! antifats ,r5go & ,m>mola4 ,hunt lat] po9t$ out 7,! ,j\rnal1 ,feb4 #a1 #aiac1 p4 #chd7 t ! am\nt ( nucle9 conta9$ 9 a dose ( ,protonucle9 probably w\ld n h ! slighte/ effect1 especially :5 giv5 by m\?4 ,! foll[+ are extracts f ! ,protonucle9 adv]tis+ matt]3 8,= canc]1 infecti\s fev]s 7measles1 sc>let fev]1 typhoid & septicaemia7 & z a prophylactic40 8,protonucle93 ,an ideal prophylactic = all infecti\s ,diseases40 8,a true alt]ative & tissue build]40 8,! value ( ,protonucle9 dep5ds ^u its ability to increase cell p[] & promote tissue /r5g?4 ,x is !re=e ne$$ :5ev] ! organism is bel[ ! normal /&>d1 m especially 9 ,anaemia1 ,typhoid1 ,neoplasms & z a ,prophylactic40 ,all ! =ego+ claims & recomm5dations are suppos$ to be bas$ on c]ta9 alleg$ discov]ies :i* ! ,c\ncil has previ\sly *>act]iz$ z 8a tissue ( vague speculations 444 9 direct conflict ) ! kn[n facts ( physiologic *emi/ry40 ,z = ! ?ird claim1 ,hunt & ,seidell h comm5t$ on ! dang] ( recomm5d+ ?yroid1 ! mo/ p[]ful tissue-de/roy+ drug kn[n1 z a 8tissue build]40 ,protonucle9 ,beta1 x is said3 8444 comb9es ! recon/ructive action ( ,protonucle9 ) ! action ( ! vital pr9ciple ( ! sple51 mak+ x a di/9ct product = use 9 all tub]cul> tr\bles1 includ+ ph?isis1 localiz$ jo9t affections & scr(ul> conditions40 ,?is product1 accord+ to ! manufactur]s1 is bas$ on ! "w ( a c]ta9 ,dr4 ,bayle ( ,cannes1 ,france4 ,dr4 ,bayle said t he _h treat$ tub]cul\s pati5ts ) fre% gr\nd up sple5 ( hogs 7#be-ajj grams p] day71 mix$ ) fruit pres]ve or b\illon2 9 cases 9 :i* ?is br\ght on ga/ro-inte/9al disord]s1 extract ( ! sple5 pulp 0 adm9i/]$ hypod]mically4 ,bayle report$ extraord9>y improvem5ts 9 ! physical & m5tal conditions ( 8 pati5ts ev5 aft] a few days ( ?is treatm5t2 ov] #ij p] c5t4 ( 8 tub]cul\s pati5ts1 accord+ to him1 improv$ or 7 cur$4 ,?is appli$ to all types & /ages ( tub]culosis 9 man4 8,) ! sple5 pulp treatm5t tub]cul\s gl&s disappe> l syphilis lesions on adm9i/ration ( m]cury & iodids40 ,?is 8sple5 specific0 ( ,bayle lacks sci5tific f\ndation2 ,bayle's own cases 7 n adequately controll$1 & no notice has be5 tak5 ( ,bayle's report by exp]ts on tub]culosis4 ,h5ce x practically lacks bo? confirmation & contradiction4 ,! sple5 is invad$ by tub]cle bacilli q z frequ5tly z are ! kidneys & ! liv]2 x has no special toxic action on ^! bacilli4 ,nor is !re any reason to believe t ! end products ( ga/ric & inte/9al dige/ion ( sple5 pulp1 aft] absorption into ! blood1 ex]t su* toxic action4 ,x _c be assum$ t ^! end products indirectly aid ! heal+ processes ?r\gh improv$ metabolism1 = !re is no evid5ce t !y h any specific nutritive or /imulat+ action aft] su* absorption4 ,altoge!r1 :at we "k ( ! physiology & pa?ology ( ! sple5 does n w>rant u 9 look+ = a 8specific0 aga9/ tub]culosis 9 ?is organ4 ,if1 h[ev]1 ! kn[n facts did ju/ify any hope t ! sple5 might furni% su* a specific1 manufactur]s w\ld n be w>rant$ 9 exploit+ or physicians 9 prescrib+ sple5 products z a rem$y = tub]culosis until control exp]im5ts on animals _h confirm$ ! !rapeutic value ( ^! products4 ,9 a *ronic disease l tub]culosis1 no conclusions t are sci5tifically valid c be drawn f cl9ical cases until _m cases h be5 obs]v$ = ye>s "u suitable conditions4 ,"r "h x may be said t ! cl9ical 8evid5ce0 (f]$ 9 favor ( ,protonucle9 ,beta is wor?less4 ,! obs]vations :i* h be5 report$ on ?is product are n su* z to p]mit any valid f9al conclusions to be drawn ) reg>d to its value4 ,! rational me?od ( prov+ ! wor? ( an alleg$ new specific su* z ?is is by animal exp]im5tation4 ,s f> z we "k1 nei!r ,dr4 ,bayle nor ! ,re$ & ,c>nrick company has p]=m$ any su* exp]im5ts ) 8sple5 pulp0 or ,protonucle9 ,beta2 nor are we aw>e t any compet5t inve/igator has done s4 ,!re is1 to ! be/ ( our k1 no sci5tific evid5ce on :i* to base ! claims = ,protonucle9 ,beta4 ,! ,c\ncil reaffirms its =m] action ) reg>d to ,protonucle94 ,! objections made to ,protonucle9 apply ) equal =ce to ,protonucle9 ,beta4 ,9 view ( ! lack ( evid5ce1 ! claims = ,protonucle9 ,beta are unw>rant$ & ! product is ineligible to ,n4 ,n4 ,r4 on acc\nt ( noncompliance ) ,rules #a1 #f & #h4--7;,f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #a1 #aiaf47 ,,hydrops9 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has adopt$ ! foll[+ report & au?oriz$ its publication4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,hydrops9 is m>ket$ by ! ,ern/ ,bis*(f ,company1 ,inc41 ,new ,york4 ,its composition is ?us describ$3 8,hydrops9 is ! /&>diz$ dialysate ( ,digitalis purpurea1 ,betula alba1 ,scilla m>itima1 ,junip]is communis1 & ,h]ni>ia glabra2 or1 /at$ o!rwise1 x is ! juice ( ^! drugs1 dialyz$ & physiologically /&>diz$40 8,ea* fluid dram repres5ts ,digitalysatum #g gtts41 & #b gtts4 ea* ( ! dialysates ( ,betula1 ,h]ni>ia1 ,junip] & ,scilla40 ,! composition ( ,hydrops9 mu/ be consid]$ ess5tially secret s9ce ! am\nts ( ! sev]al con/itu5t drugs 9 a giv5 am\nt ( 8dialysate0 are n disclos$4 ,! active pr9ciple ( junip] is a volatile oil :i* is practically insoluble 9 wat]2 x is difficult to believe t ! 8juice0 ( junip] submitt$ to dialysis c\ld conta9 any mat]ial am\nt ( ! active con/itu5t4 ,no in=mation is giv5 z to ! me?od us$ :]eby ! sev]al dialysates are 8physiologically /&>diz$40 ,x !re=e rema9s to be prov$ t ! manufactur] ( ,hydrops9 possesses any me?od :]eby ! dialysates ( junip] 7,junip]is communis71 bir* 7,betula alba1 ! common ,european bir*7 & knot we$ 7,h]ni>ia glabra7 are s /&>diz$4 ,! claim is made t3 8,h]ni>ia has long be5 recogniz$ z "o ( ! mo/ valuable drugs 9 ! treatm5t ( dropsical affections due to c>diac impairm5t40 ,on ! contr>y1 ,h]ni>ia belongs to t l>ge class ( drugs :i* h be5 tri$1 f\nd want+ & ab&on$4 ,x is a v old rem$y1 & ! claims made = x are an inh]itance f ! e>ly h]bali/s1 ) :om x 0 v popul>4 ,accord+ to ,k+'s ,am]ican ,disp5satory1 x 0 8pr9cipally employ$ to cure h]nia 7h5ce its "n7 & to increase ! fl[ ( ur9e4 ,x 0 also said to increase ! fl[ ( bile4444 ,int]nally & ext]nally1 x 0 prais$ 9 snake-bites1 & ! p[d]$ plant 0 employ$ to kill maggots on unheal?y sores ( horses4 ,x 0 reput$ to #8cru%' & expel calculi f ! kidneys & bladd]44440 ,! ,ern/ ,bis*(f ,company says t3 8,betula ex]ts bo? an antiseptic & /imulat+ influ5ce on ! ur9>y passages & is p>ticul>ly s]viceable :]e a cat>rhal condition ( ! bladd] exi/s4 ,:5 comb9$ ) o!r diuretics1 z 9 ,hydrops91 ! drug af=ds highly satisfactory results 9 ! treatm5t ( ascites1 c>diac dropsy & hydro?orax40 ,bir* is ano!r drug :i* has be5 disc>d$4 ,few textbooks on mat]ia m$ica ev5 m5tion x4 ,t x c mat]ially affect ! action ( su* p[]ful drugs z squill & digitalis is exce$+ly d\btful4 ,an unw>rant$ implication--t 9 ?is prep>ation ! p[]ful drugs digitalis & squill h be5 depriv$ ( _! dang]\s qualities--is ! ass]tion3 8,dialysis1 remov+ all res9s & colloidals1 results 9 bett] tol]ance on "p ( s5sitive pati5ts1 & 9 m rapid absorption & elim9ation2 :i*1 9 turn1 means e>ly !rapeutic effects & little or no fe> ( toxic accumulation40 ,t removal ( colloids & res9s mat]ially affects ! tol]ance ( ^! drugs is improbable4 ,to claim t because ( _! removal1 !re ne$ be 8little or no fe> ( toxic accumulation0 is utt]ly )\t w>rant4 ,! claim t "o prep>ation conta9+ digitalis is less likely to produce cumulative effect ?an any o!r digitalis prep>ation is contradict$ by a mass ( evid5ce4 ,x is claim$ t ,hydrops9 affects 8favorably all =ms ( dropsy or ,edema t are at all am5able to m$ical treatm5t40 ,!re c be no "q b t squill & digitalis1 or1 bett]1 ei!r s+ly1 us$ 9 suitable cases1 may relieve dropsical effusions2 b to claim t su* a complex mixture z ,hydrops9 c favorably affect all =ms ( dropsy t are am5able to m$ical treatm5t is on its face unw>rant$4 ,! claim is made t3 8,by reason ( its unusual pot5cy & relative h>mlessness1 ,hydrops9 may be employ$ to great advantage 9 all cases :]e x is desirable to increase ! volume ( ur9e )\t injury to ! r5al /ructures40 ,on ! basis ( ! claim$ composition1 ! action ( ,hydrops9 mu/ be ess5tially t ( digitalis or ( digitalis & squill4 ,consequ5tly1 if x possesses 8unusual pot5cy10 x _c possess 8relative h>mlessness10 & vice v]sa4 ,nei!r digitalis nor squill %\ld be employ$ 89 all cases0 ( nephritis1 ev5 if x is 8desirable to increase ! volume ( ur9e40 ,! composition claim$ = ,hydrops9 br&s x z an irrational mixture 9 :i* pot5t drugs are comb9$ )1 & m or less cov]$ up by1 o!rs t are obsolete & ineffici5t4 ,! "n1 in/ead ( indicat+ its composition1 sugge/s diseases 9 :i* x may be ?\ghtlessly & indiscrim9ately us$4 ,! claim t ! dang] ( toxic or cumulative action has be5 remov$1 if accept$ by physicians1 t5ds to uncritical use ) possible disa/r\s results4 ,hydrops9 is ineligible = ,new & ,non(ficial ,rem$ies because ( conflict ) ,rules #a1 #b1 #f1 #h & #aj4--7;,f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #h1 #aiaf47 ,,digitalysatum ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has adopt$ ! foll[+ report & au?oriz$ its publication4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,digitalysatum is sold 9 ! ,unit$ ,/ates by ,ern/ ,bis*(f ,company1 ,inc41 ,new ,york4 ,! firm claims t x is a dialysate prep>$ f ! juice ( fre%ly ga!r$ digitalis1 conta9+ all ! active pr9ciples1 & repres5t+ ! fre% plant weight = weight4 ,x is said to be /&>diz$ physiologically & to conta9 #ab p] c5t4 alcohol4 ,/]isol-,digitalysatum1 int5d$ = injection1 appe>s to be ! 8dialysate0 )\t alcohol1 dilut$ ) equal p>ts ( physiologic sodium *lorid solution4 ,! ,c\ncil "s ye>s ago f\nd bo? products ineligible = ,new & ,non(ficial ,rem$ies because ( unw>rant$ !rapeutic claims4 ,! prep>ations are /ill be+ adv]tis$ to physicians "u claims :i* imply sup]iority to all o!r digitalis prep>ations4 ,= in/ance3 8,digitalysatum is ! diuretic p> excell5ce 9 c>diac insuffici5cy 4440 8,digitalysatum z a diuretic & c>diac /imulant is 9 a class by itself1 be+ quick ( action1 uni=m 9 /r5g?1 & well tol]at$40 8,digitalysatum diff]s f o!r =ms ( digitalis 9 ^! respects3444 ,digitalysatum is free f fat1 res9s & colloids1 & is !re=e well-borne by s5sitive pati5ts--! "y & ! feeble--& is quickly absorb$ & elim9at$44440 ,! ,c\ncil has else:]e#bh express$ ! conviction t t9cture ( digitalis produces ! full !rapeutic effects ( digitalis2 t1 :5 prop]ly made1 ! t9cture is z /able z any liquid prep>ation ( digitalis n[ available1 & t attempts to enhance ! reputation ( propriet>y products by exagg]at+ ! disadvantages ( ! (ficial prep>ation are to be deplor$4 ,no adequate evid5ce is (f]$ ( ! claim$ sup]iority ( action ( ,digitalysatum4 #bh ,report on ,propriet>y ,digitalis ,prep>ations1 ,j4 ,a4 ,m4 ,a41 ,dec4 #d1 #aiae1 p4 #bjbd4 ,by implication1 ! claim is made t ,digitalysatum is sup]ior to o!r digitalis prep>ations 9 respect to toxicity3 8,free f fat1 res9s & colloidals1 x is always well borne & is quickly absorb$ & elim9at$4 ,no case ( toxic accumulation 7faulty elim9ation7 has ev] be5 report$40 ,t ,digitalysatum is free f ! dang]s ( toxic cumulation is highly improbable2 9 fact1 x is inconsi/5t ) ! /atem5t t ! prep>ation conta9s all ! con/itu5ts f\nd 9 ! fre% plant4 ,ev5 if in/ances ( cumulative action h n be5 report$ ?is does n prove t su* cumulative action does n occur4 ,! t9cture ( digitalis has ! sy/emic side-effects ( digitalis 9 no great] degree ?an ! v>i\s propriet>y prep>ations4 ,attempts to create ! impression t ,digitalysatum possesses all ! virtues ( digitalis )\t its *ief disadvantage are to be condemn$ z likely to lead to incauti\s use ( ! prep>ation4 ,^! exagg]at$ claims are 9 ! ma9 made indirectly1 b !y are none ! less inimical to s\nd !rapy4 ,! ,c\ncil !re=e decl>$ ,digitalysatum ineligible = ,new & ,non(ficial ,rem$ies & vot$ t ?is report be publi%$4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #h1 #aiaf47 ,,s-,,call$ ,,secret9 ,,prep>ations ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil au?oriz$ ! foll[+ report = publication1 & vot$ to endorse ! "w ( ,pr(essor ,c>lson discuss$ !re94 ,w4 ,a4 ,puckn]1 ,secret>y4 ,! ,c\ncil has n accept$ = inclusion 9 ,new & ,non(ficial ,rem$ies any prep>ations said to conta9 secret9 or prosecret9 z _! active +r$i5t4 ,a report giv+ ! reasons = ! rejection ( "o 7! fir/ ( ! s-call$ secret9 prep>ations m>ket$7 0 publi%$ e>ly la/ ye>2#bi an article on secret91 bas$ on "w und]tak5 at ! reque/ ( ! ,c\ncil on ,ph>macy & ,*emi/ry1 is n[ publi%$4#cj #bi ,secretog51 ,j4 ,a4 ,m4 ,a41 ,may #a1 #aiae1 p4 #aeah4 #cj ,c>lson1 ,a4 ,j42 ,leb5sohn1 ,j4 ,e41 & ,pe>lmann1 ,s4 ,j43 ,has ,secret9 a ,!rapeutic ,value8 ,j4 ,a4 ,m4 ,a4 #ff3agh 7,jan4 #ae7 #aiaf4 ,le/ ! appe>ance ( ?is detail$ /udy ( secret91 aft] ! rejection ( s-call$ secret9 prep>ations1 %\ld be int]pret$ 7z manufactur]s ^: products h be5 reject$ h endeavor$ to int]pret su* action7 z a case ( fir/ condemn+ a prep>ation & !n gett+ ! facts1 ! ,c\ncil's me?ods1 & _! application 9 ?is case1 may be briefly /at$4 ,! ,c\ncil ma9ta9s t1 :5 a manufactur] places a product on ! m>ket1 ! burd5 ( pro( is on t manufactur] to %[ t ! prop]ties ( 8 product are 9 accordance ) 8 claims = x4 ,z /at$ 9 ! introduction to ,n4 ,n4 ,r41 8x is 444 manife/ly impossible = ! ,c\ncil to inve/igate ! composition ( e complex ph>maceutical mixture1 or to *eck ?or\ghly e !rapeutic claim2 x c give only an unbias$ judgm5t on ! available evid5ce40 ,act+ on ?is pr9ciple1 ! ,c\ncil exam9$ ! claims made = ,secretog51 an alleg$ secret9 product manufactur$ by ! ,g4 ,w4 ,c>nrick ,company4 ,! conclusion 0 t ^! claims 7 9 absolute conflict ) ! available evid5ce z to ! action ( secret94 ,x is n necess>y to review ?is subject aga94 ,x w suffice to /ate t ! claims made = ,secretog5 re/ on two fundam5tal propositions3 7#a7 t defici5cy ( secret9 7or1 r1 ( prosecret97 9 ! inte/9al mucosa is a factor 9 ga/ro-inte/9al diseases2 7#b7 t secret9 giv5 by ! m\? is absorb$ & produces increas$ secretion ( ! pancreatic & inte/9al juices & ( ! bile4 ,f an exam9ation ( ! evid5ce available1 includ+ t submitt$ by ! manufactur]s1 ! ,c\ncil conclud$3 8#a4 ,no evid5ce has be5 pres5t$ t ! abs5ce ( secret9 is a cause ( ga/ro-inte/9al disease4 #b4 ,!re is no evid5ce t secret9 9 any =m is physiologically active :5 adm9i/]$ by m\?40 ,t ^! conclusions 7 ju/ifi$ is %[n aga9 by ! review giv5 by ,c>lson ( ! lit]ature1 mu* ( :i* 0 also review$ 9 ! ,c\ncil's previ\s report4 ,s9ce ! claims ( ! ,c>nrick ,company 7 n support$ by any satisfactory evid5ce1 no fur!r inve/igation on ! ,c\ncil's "p 0 necess>y to w>rant rejection ( ! product4 ,! ,c\ncil did n und]take to det]m9e1 = in/ance1 :e!r or n ,secretog5 & simil> products actually conta9 secret92 ! det]m9ation ( ?is po9t 0 immat]ial "h1 9 view ( ! conclusiv5ess ( ! evid5ce t secret9 giv5 by m\? has no physiologic action4 ,s9ce firms o!r ?an ! ,g4 ,w4 ,c>nrick ,company are manufactur+ alleg$ secret9 prep>ations1 & s9ce recomm5dations = ! use ( secret9 prep>ations 9 ga/ro-inte/9al diseases h ev5 crept into textbooks1 x seem$ desirable to obta9 fur!r in=mation on c]ta9 po9ts4 ,! ,c\ncil !re=e reque/$ ,pr(4 ,a4 ,j4 ,c>lson ( ! ,univ]sity ( ,*icago to *eck ! results ( previ\s inve/igators ) reg>d to ! action ( secret9 adm9i/]$ by m\? or directly into ! inte/9e1 &1 9 addition1 to inve/igate ! secret9 cont5t ( c]ta9 alleg$ secret9 prep>ations4 ,c>lson & 8 co-work]s1 l all previ\s inve/igators1 f\nd t secret9 giv5 by m\?1 or introduc$ ev5 9 enorm\s doses directly into ! inte/9e1 is entirely inactive4 ,!y also f\nd t m>k$ de/ruction ( secret9 foll[$ contact = "o m9ute ) human ga/ric juice & t secret9 is rapidly oxidiz$ & r5d]$ in]t 9 contact ) ! air4 ,fur!r1 !y 7 unable to demon/rate ! pres5ce ( secret9 9 samples ( ,secretog5 & ano!r suppos$ secret9 prep>ation 7,duod597 b\ght on ! op5 m>ket4 ,9 ! case ( ,secretog5 !re 0 "o exception3 "o bottle 0 f\nd :i* conta9$ a little secret91 b x 0 necess>y to adm9i/] 7by intrav5\s injection1 ( c\rse7 ! entire cont5ts ( ! bottle 7#ajj tablets7 to obta9 8a small b unmi/akable secret9 reaction40 ,9 ^! /udies ! me?ods employ$ 7 ^? by :i* secret9 0 discov]$4 ,x is only by ! use ( su* me?ods t ! pres5ce or abs5ce ( secret9 c be det]m9$4 ,app>5tly ! manufactur]s :o place s-call$ secret9 prep>ations on ! m>ket d n make use ( ^! me?ods1 by :i* alone ev5 ! composition ( _! products c be det]m9$4 ,c>lson & 8 collaborators conclude3 8,!re is z yet no reliable evid5ce t lack ( secret9 is a prim>y or important factor 9 any disease4 ,ev5 %\ld ?is be e/abli%$1 secret9 !rapy1 to be effective1 mu/ be intrav5\s4 ,secret9 has n yet be5 prep>$ 9 suffici5tly pure /ate to r5d] possible intrav5\s injection 9 man )\t injuri\s effects4 ,& ev5 :5 ?is is atta9$1 ! v fleet+ action ( secret9 w 9 all probability r5d] secret9 !rapy z futile 9 all ! diseases 9 :i* x is !oretically indicat$ z ep9ephr9 !rapy is 9 ,addison's disease40 ,9 %ort1 secret9 is z ineffective tak5 by m\? z x w\ld be rubb$ on ! sk94 ,! ref]ee recomm5ds t ! "w ( ,pr(essor ,c>lson be endors$4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #ae1 #aiaf47 ,,has ,,secret9 ,a ,,!rapeutic ,,value8,b ,a4 ,j4 ,c>lson1 ,ph4,d41 ,j4 ,e4 ,leb5sohn1 ,m4,s41 & ,s4 ,j4 ,pe>lman1 ,b4,s4 ,*icago ,b ,f ! ,hull ,physiological ,laboratory ( ! ,univ]sity ( ,*icago4 ,b ,?is inve/igation 0 und]tak5 at ! reque/ ( ! ,c\ncil on ,ph>macy & ,*emi/ry4 ,! foll[+ report1 hav+ be5 submitt$ to ! ,c\ncil1 receiv$ its endorsem5t 7see prec$+ report ( ! ,c\ncil on ,ph>macy & ,*emi/ry1 8,s-,call$ ,secret9 ,prep>ations074 ,x is well e/abli%$ t acid *yme 9 ! duod5um is ! normal /imulus to ! secretion ( pancreatic juice4#ca ,int]action ( ! acid ) ! duod5al mucosa lib]ates into ! blood /ream a sub/ance :i*1 circulat+ ?r\gh ! pancreas1 excites ! latt] to activity4 ,?is excit+ sub/ance has be5 t]m$ 8secret940 ,x c be prep>$ artificially by mac]at+ duod5ojejunal mucosa 9 #j4d p] c5t4 hydro*loric acid1 neutraliz+ ! boil+ mixture1 & filt]+4 ,a few cubic c5timet]s ( ! filtrate inject$ into a ve9 produce inv>iably a p[]ful secretion ( pancreatic juice4#cb ,t a 8*emical mess5g]0 is at ! basis ( ! duod5al acid reflex has be5 prov$ by ev5 m crucial exp]im5ts--transfusion 7,w]!im]1#cc ,enriquez & ,hallion#cd71 cross circulation 7,fleig1#ce ,matuso#cf71 & p]fusion ( ! isolat$ pancreas 7,hu/on#cg74 #ca ,pawl[3 ,! ,"w ( ! ,dige/ive ,gl&s1 #aiab4 #cb ,bayliss & ,/>l+3 ,j\r4 ,physiol4 #bh3cbe1 #aijb4 #cc ,w]!im]3 ,compt4 r5d4 ,soc4 de biol4 #ed3dge1 #aijb4 #cd ,enriquez & ,hallion3 ,compt4 r5d4 ,soc4 de biol4 #ee3bcc1 #cfc1 #aijc4 #ce ,fleig3 ,ar*4 int]nat4 de ,physiol41 #aj3bjf1 #aiaj4 #cf ,matuso3 ,j\r4 ,physiol4 #de3dgg1 #aiac4 #cg ,hu/on3 ,ann4 et bull4 ,soc4 roy4 de sc4 md4 et nat4 #gj3agh1 #aiab4 ,,prop]ties ,,( ,,secret9 ,prosecret94--,secret9 is soluble 9 wat]1 yet a wat]y extract ( inte/9al scrap+s is )\t action1#cb ev5 aft] be+ submitt$ to acid treatm5t4#ch ,/>l+ !re=e holds t secret9 exi/s 9 ! inte/9al mucosa 9 an inactive =m1 z 8prosecret940 ,! cont5t ( ! inte/9e 9 prosecret9 decreases f ! duod5um d[n1 s t "o is unable to demon/rate any prosecret9 9 ! la/ #b-a_/b feet ( ! ileum4 ,prosecret9 is insoluble 9 wat]1 acetone1 absolute alcohol or e!r4 ,secret91 on ! o!r h&1 is readily soluble 9 wat]1 normal salt solution & dilut$ alcohol 7#gj p] c5t471 b likewise insoluble 9 absolute alcohol & e!r4 #ch ,/>l+3 ,lancet1 ,london #b3dcc1 #aije4 ,prep>ation4--,all ( ! m dissociat$ acids lib]ate secret9 f inte/9al mucosa on boil+4 ,_! action is dep5d5t on ! degree ( dissociation1#ci c>bonic & boric acids be+ inactive4#dj ,secret9 c also be prep>$ ) /rong soaps 7f #aj to #cj p] c5t4 sodium oleate71 alcohol 7#gj p] c5t41#da #j4f p] c5t4 sodium *lorid#cf74 ,! acid & soap 9 ! duod5um produce secretion2 !re is no necess>y correspond5ce betwe5 ! action ( a sub/ance 9 ! inte/9e & t obta9$ by injection aft] boil+ mucosa ) x4 ,! sodium *lorid1 bile1 maltose & glucose produce "s secretion by ! latt] me?od yet none by ! =m]4#cf ,on ! o!r h&1 e!r1 *loral & oil ( mu/>d excite secretion :5 9 ! inte/9e1 b no secret9 c be prep>$ f boil$ mucosa by _! action4 ,! irritation ( ! l9+ cell has produc$ ! necess>y hydrolysis4#ch ,9 well-controll$ exp]im5ts1 ,w]!im] & ,le,page#db f\nd t aft] ! introduction ( acid1 secretion is secret$ into ! lum5 ( ! inte/9e4 ,matuso#cf confirm$ _! results1 & f\nd ?is a satisfactory me?od = ! prep>ation ( secret94 ,x is said t secret9 c be obta9$ by m]ely boil+ ! mucosa ) wat]1 b ! results are incon/ant4#dc #ci ,fr\9 & ,lal\3 ,compt4 r5d4 ,soc4 de biol41 #ga3ahi1 #aiaa4 #dj ,camus3 ,compt4 r5d4 ,soc4 de biol41 #aijb1 #ed3ddb1 #aijb4 #da ,fleig3 ,j\r4 de physiol4 et de pa?4 gn4 #f3cb1 #ej1 #aijd4 #db ,w]!im] & ,le,page3 ,j\r4 de physiol4 et de pa?4 gn4 #d3ajfa1 #ajgj1 #aijb4 #dc ,/epp3 ,j\r4 ,physiol4 #dc3dda1 #aiab4 ,action4--,secret9 is an excitant n only ( ! pancreatic juice b also ( ! liv] & ! inte/9al mucosa4 ,! fl[ ( bile is m>k$ly accel]at$ 7,h5ri & ,porti]1#dd ,enriquez & ,hallion#de71 likewise t ( succus ent]icus 7,delez5ne & ,fr\91#df ,bottazzi & ,gabrielli#dg71 & inte/9al p]i/alsis is /imulat$ 7,enriquez & ,hallion1#dh ,falloise#di74 ,injections ( secret9 produce a m>k$ vasodilatation1 b ! secretory effect is indep5d5t ( ! blood pressure *anges4 ,! pancreas is n readily fatigu$ by secret94 ,bayliss & ,/>l+#ej h obta9$ undim9i%$ fl[ aft] eight h\rs ( cont9u\s injection4 ,our exp]i5ce confirms ?is result4 ,also1 equal doses ( secret9 give correspond+ results at v>i\s int]vals4 ,moreov]1 ane/hesia does n affect ! fl[4 ,secret9 is unrecov]able f ! gl&s ev5 aft] two h\rs ( cont9u\s injection4#ea ,! juice obta9$ by secret9 has be5 subject to _m /udies4#eb ,x is ( high alkal9ity 7ab\t sev5? normal71 conta9s all ! pancreatic f]m5ts1 & corresponds 9 all respects to ! juice obta9$ 9 dige/ion f p]man5t pancreatic fi/ulas4#ec #dd ,h5ri & ,porti]3 ,compt4 r5d4 ,soc4 de biol4 #ed3fbj1 #aijb4 #de ,enriquez & ,hallion3 ,presse md4 #a3aje1 #aijc4 #df ,delez5ne & ,fr\93 ,compt4 r5d4 ,soc4 de biol4 #ef3cai1 #aijd4 #dg ,bottazzi & ,gabrielli3 ,ar*4 int]nat4 de physiol4 #aaa3aef1 #aije4 #dh ,enriquez & ,hallion3 ,bull4 gn4 de ?r4 #afb3bjb1 #aiaa4 #di ,falloise3 ,bull4 de l',acad4 roy4 de ,belgique #e3ide1 #aijb4 #ej ,bayliss & ,/>l+ 7,note #b74 ,matuso 7,note #f74 ,ar*4 int]nat4 de physiol4 #aj3cce1 #aiaa4 #ea ,dixon & ,hamill3 ,j\r4 ,physiol41 #aiji1 xxxv1 #cad4 #eb ,bayliss & ,/>l+3 ,j\r4 ,physiol41 #aijd1 xxx1 #fa4 ,bi]ry3 ,compt4 r5d4 ,soc4 de biol41 #aijg1 lxii1 #dcc4 ,bi]ry & ,t]ro9e3 ,compt4 r5d4 ,acad4 de sc41 #aije1 cxli1 #adf4 ,lal\3 ,comp4 r5d4 ,acad4 de sc41 #aiaj1 xxix1 #hbd4 ,morel3 ,compt4 r5d4 ,soc4 de biol41 #aiji1 lxvii1 #cf4 ,/rassano & ,billoro3 ,compt4 r5d4 ,soc4 de biol41 #aijb1 liv1 #icg4 #ec ,bayliss & ,/>l+ 7,note #bc74 ,specificity4--,9 a mac]ation ( ! duod5ojejunal mucosa1 su* z we h 9 secret91 ! kn[n sub/ances are proteoses & peptones1 acid am9s1 bile salts1 beta-imidazole?ylam91 *ol91 gelat9 & inorganic salts4 ,^! sub/ances1 individually & sev]ally1 toge!r ) _! d]ivatives1 are devoid ( secretory action4 ,*emically1 secret91 is !n a specific entity4 ,b l ep9ephr91 9 its di/ribution1 x is nonspecific4 ,active prep>ations h be5 made f an extraord9>y v>iety ( animals among ! diff]5t classes ( v]tebrates 7,camus1#ed ,bayliss & ,/>l+1#ee ,*apman#ef74 ,x is likewise f\nd 9 ! new-born & 9 ! fetus4#eg ,its action1 h[ev]1 l its *emical composition1 is m>k$ly specific4 ,x /imulates ! fl[ ( pancreatic juice1 bile & succus ent]icus4 ,its effect on ! ga/ric gl&s is negative1 & on ! saliva likewise4#eh ,on ! o!r h&1 no o!r extracts produce pancreatic secretion4 ,dr4 ,ko*1 :o1 9 collaboration ) ,dr4 ,keeton & ,dr4 ,luckh>dt1 has done ! mo/ rec5t "w on ga/r9#ei 7a sub/ance t mo/ ne>ly resembles secret97 & has isolat$ an extremely active prep>ation1 f9ds t ga/r9 injection has likewise no effect on ! pancreas4 ,camus & ,gley1#fj ) crude prep>ations1 _h previ\sly obta9$ a simil> result4 #ed ,camus3 ,j\r4 de physiol4 et de pa?4 gn4 #d3iih1 #aijb4 #ee ,bayliss & ,/>l+3 ,j\r4 ,physiol4 #bi3agd1 #aijc4 #ef ,*apman3 ,proc4 ,l9naean ,soc41 ,new ,s\? ,wales #a3ib1 #aije4 #eg ,camus3 ,compt4 r5d4 ,soc4 de biol4 #fa3ei1 #aijf4 ,hallion & ,lequex3 ,compt4 r5d4 ,soc4 de biol4 #fa3cc1 #aijf4 #eh ,d]\aux3 ,ar*4 int]nat4 de physiol4 #c3dd1 #aije4 ,lamb]t & ,my]3 ,compt4 r5d4 ,soc4 de biol4 #ed3ajdd1 #aijb4 ,/>l+3 ,lancet1 ,london #b3eja1 #aije4 #ei ,keeton & ,ko*3 ,am4 ,j\r4 ,physiol4 #cg3dha1 #aiae4 #fj ,camus & ,gley3 ,compt4 r5d4 ,soc4 de biol4 #ed3fdh1 #aijb4 ,lability4--,neutral secret9 is b feebly attack$ by a temp]ature ( #ajj ,c4 ,if heat$ 9 an autoclave 7s z to prev5t oxidation71 ?is temp]ature c be cont9u$ = ?irty m9utes )\t any *ange 9 its activity4 ,increas+ ! temp]ature increases ! spe$ ( de/ruction1 s t at #adj ,c4 ! de/ructive action is m>k$4#fa ,autoclav+ at #ae p\nds = fifte5 m9utes1 z an ord9>y /]ilization ( culture m$iums1 produces1 we f\nd1 a di/9ct ?\gh n s]i\s decrease 9 activity4 ,secret9 acidifi$ to fif?-normal ) hydro*loric acid loses #fj p] c5t4 ( its activity on fifte5 m9utes boil+4 ,secret91 alkal9iz$ to fif?-normal ) sodium hydroxid loses #ie p] c5t4 ( its activity 9 five m9utes' boil+2 decreases to a trace 9 ?irty m9utes1 & disappe>s entirely 9 sixty m9utes4 ,at room temp]ature1 ) fif?-normal alkal9ity1 #hj p] c5t4 ( secret9 is de/roy$ 9 eight h\rs4#fa ,! de/ruction probably means a second>y cleavage ( ! secret9 molecule itself4 #fa ,lal\ 7,note #ba74 ,may3 ,j\r4 ,physiol4 #cj3djj1 #aijd4 ,secret9 is oxidiz$ readily4 ,if left /&+ uncov]$ = a summ]'s day1 ! prep>ation w be inactive4#ea ,ev5 if kept 9 ! ice-*e/ 7no o!r precaution be+ tak571 its activity is lo/ 9 a v few days4 ,sunlight und\bt$ly ha/5s ! oxidative process4 ,if c>e is tak5 z to /]ility1 h[ev]1 & ! secret9 is kept 9 ! ice-*e/1 well /opp]$ & 9 a d>k flask1 x w reta9 its activity = sev]al weeks4 ,dixon & ,hamill#ea claim$ t secret9 disappe>s quantitatively on passage ?r\gh a ,b]kefeld filt] at #e mm4 pressure4 ,lal\1#fb us+ high] pressure1 0 unable to confirm ! f9d+1 b obta9$ a m>k$ decrease 9 activity4 ,our results are 9 accord ) ^? ( ,lal\4 #fb ,launoy3 ,ar*4 int]nat4 de ,physiol4 #c3fb1 #aijf4 ,morel & ,t]ro9e3 ,compt4 r5d4 ,soc4 de biol4 #fg3cf1 #aiji4 ,zunz3 ,ar*4 int]nat4 de physiol4 #h3aha1 #aiji4 ,lal\3 ,j\r4 de physiol4 #ad3dfe1 #aiab4 ,analogy to ,ep9ephr94--,! analogy ( secret9 to ep9ephr9 does n g5]ally receive en\gh emphasis4 ,bo? sub/ances are nonspecific 9 di/ribution1 b specific *emically1 & especially physiologically1 ep9ephr9 act+ on ! myoneural junctions1 secret9 on inte/9al dige/ion4 ,!y are bo? relatively simple sub/ances ( l[ molecul> weight1 & subject to rapid oxidation :]eby _! prop]ties disappe>4 ,! action 9 bo? cases is v transi5t4 ,!y are ! two examples ( :at ,/>l+ calls ! 8acute hormones10 9 :i* x is ess5tial t reaction take place imm$iately1 & %all disappe> z soon z ! excit+ cause is remov$4#fc #fc ,/>l+3 ,proc4 ,roy4 ,soc4 ,m$41 #h1 ,no4 #d1 #aiad1 ,!rap4 & ,ph>m4 ,section1 p4 #bi4 ,,cl9ical ,,use ,,( ,,secret9 ,diabetes ,mellitus4--,moore1 ,edie & ,abram#fd 7 ! fir/ to sugge/ a !rapeutic value = secret91 hav+ obta9$ favorable results ) secret9 adm9i/ration 9 diabetes4 ,!y argu$ t ! int]nal secretion ( ! pancreas may be /imulat$ by secret91 & t "s cases ( diabetes may be due to lack ( ?is necess>y excitant4 ,ow+ to ! importance ( ! "q1 _! ann\ncem5t 0 foll[$ quickly by num]\s inve/igations by o!r obs]v]s4 ,previ\sly1 ,spriggs1 at ! sugge/ion ( ,/>l+1 _h tri$ intrav5\s injections ( secret9 free f depressor sub/ance 9 a diabetic pati5t1 & _h obta9$ negative results4 ,moore1 ,edie & ,abram gave _! secret9 by m\? ov] long p]iods4 ,( ! five cases cit$ 9 _! fir/ pap]1 two 7 negative4 ,! ?ird 0 t ( a man1 ag$ #be1 :o receiv$ daily #cj c4c4 ( secret94 ,aft] a lat5t p]iod ( ?ree weeks1 ! sug> sudd5ly fell1 & aft] f\r mon?s ! ur9e 0 sug>-free4 ,six mon?s lat] a relapse occurr$ ) ! developm5t ( ph?isis & dea?4 ,! o!r two pati5ts 7 a boy1 ag$ #g1 & a girl1 ag$ #i1 ^: ur9e 9 f ?ree to five weeks became sug> free dur+ ! secret9 treatm5t 9 spite ( sev]e diabetes4 ,"o ( ^! pati5ts lat] relaps$4#fe ,ba9bridge & ,b$d>d#ff gave secret9 a ?or\gh trial 9 ?ree cases ) negative results1 & are dispos$ to attribute ! results ( ,moore to diet+4 ,dak9 & ,ransom#fg cit$ "o case1 secret9 be+ giv5 = twelve weeks1 ) negative results2 ,fo/]1#fe n9e cases1 all negative2 ,*>les1#fh ?ree cases1 all negative4 ,cr(ton1#fi h[ev]1 gave secret9 a trial 9 "o case ) favorable results4 ,moore1 ,edie & ,abram1 9 a lat] pap]1#gj report a l>ge numb] ( cases tri$ ) ! majority ( results negative1 ?\gh 9 "s cases an improvem5t 9 ! dige/ion1 & 9 c]ta9 cases an increase ( weight 0 not$4 #fd ,moore1 ,edie & ,abram3 ,bio*em4 ,j\r41 #a3bh1 #aijf4 #fe ,fo/]3 ,j\r4 ,biol4 ,*em41 #b3big1 #aijf4 #ff ,ba9bridge & ,b$d>d3 ,bio*em4 ,j\r41 #a3dbi1 #aijf4 #fg ,dak9 & ,ransom3 ,j\r4 ,biol4 ,*em41 #b3cje1 #aijf4 #fh ,*>les3 ,m$4 ,press & ,cir41 #acc3egh1 #aijf4 #fi ,cr(ton3 ,lancet1 ,london1 #agf3fjg1 #aiji4 #gj ,moore1 ,edie & ,abram3 ,bio*em ,j\r41 #c3hb1 #aijh4 ,"o me?od ( te/+ ! basis ( ,moore's !ory w\ld be by exam9+ ! prosecret9 cont5t ( ! inte/9e 9 diabetics4 ,ba9bridge & ,b$d>d f\nd1 9 ! pap] ref]r$ to1#ff t f five ( ! six cases ( diabetics exam9$ po/mortem1 little or no secret9 c\ld be prep>$2 b 9 a subsequ5t report ( sev5 cases1#ga !y f\nd only "o 9 :i* ! secret9 obta9$ 0 scanty4 ,! failure to obta9 secret9 9 "s cases !y claim is probably due to ! rapid po/mortem deg5]ation ( diabetic tissue4 ,evans1#gb 9 ,/>l+'s laboratory1 f\nd t 9 dogs made rec5tly diabetic by total pancreatectomy1 b little secret9 c\ld be obta9$4 ,h$on & ,lisbonne1#gc & ,pemb]ton & ,sweet#gd report1 on ! contr>y1 t ! duod5um ( diabetic dogs is ri* 9 prosecret94 ,ba9bridge & ,b$d>d1#ga work+ on a diabetic cat1 likewise f\nd prosecret9 to be pres5t 9 normal quantity4 #ga ,ba9bridge & ,b$d>d3 ,bio*em4 ,j\r4 #c3hb1 #aijh4 #gb ,evan3 ,j\r4 ,physiol4 #dd3dfa1 #aiab4 #gc ,h$on3 ,compt4 r5d4 ,soc4 de biol4 #gd3cge1 #aiac4 #gd ,pemb]ton1 ,ralph1 & ,sweet1 ,j4 ,e43 ,fur!r ,/udies on ! ,influ5ce ( ! ,ductless ,gl&s on ! ,pancreas1 ,ar*4 ,int4 ,m$41 ,may1 #aiaj1 p4 #dff4 ,dige/ive ,di/urbances4--,secret9 = dige/ive di/urbance 0 fir/ us$ 9 ! 8acid duod5al m$ication0 ( ,enriquez4#ge ,?is consi/$ 9 ! giv+ ( t>t>ic acid 9 ?ick k]at9 capsules1 ! acid n be+ lib]at$ until ! duod5um 0 rea*$1 :]e x provok$ ! =mation ( secret94 8,! secret9 me*anism10 he says1 8is probably capable ( pa?ologic di/urbance z w\ld result1 = example1 ) dim9i%$ acidity ( *yme1 di/urbance ( ! normal motility ( ! /oma* or pylorus1 or dim9i%$ prosecret9 9 ! mucosa4 ,su* a condition w\ld produce di/urbance ( ! pancreatic1 bili>y & inte/9al secretions1 & int]f]e ) inte/9al movem5ts1 ) a cl9ical syndrome ( inte/9al dyspepsia z a result1 among ! *ief & mo/ con/ant symptoms ( :i* w\ld be con/ipation40 8,! acid duod5al m$ication0 0 submitt$ to wide cl9ical use1 & v favorable results 9 c]ta9 ob/9ate cases ( con/ipation 7 report$4 ,9 reg>d to 8dim9i%$ prosecret9 9 ! mucosa10 ,w5twor?#gf has claim$ t 9 infantile atrophy su* is ! condition1 b ,sweet & ,pemb]ton#gg h f\nd t ! difficulty ( prep>+ secret9 f human duod5ums is su* z to r5d] ,w5twor?'s f9d+s inconclusive4 #ge ,enriquez3 ,bull4 du ,lab4 de biol4 ,appliq4 #b1 ,no4 #b-,no4 #h1 #aijd4 #gf ,w5twor?1 ,a4 ,h43 ,! ,cause ( ,infantile ,atrophy1 ,j4 ,a4 ,m4 ,a41 ,july #bj1 #aijg1 p4 #bjd4 #gg ,sweet1 ,j4 ,e41 & ,pemb]ton1 ,ralph3 ,exp]im5tal ,obs]vations on ,secret91 ,ar*4 ,int4 ,m$41 ,febru>y1 #aijh1 p4 #bca4 ,bev]idge#gh sugge/s ! use ( secret9 9 7a7 pyloric /5osis1 7b7 pancreatic insuffici5cy1 7c7 hepatic /imulation & cirrhosis ( ! liv] 7d7 to /imulate p]i/alsis 9 colonic /asis1 7e7 9 ga/ro-ent]o/omy & %ort-circuit+ ( ! inte/9es4 ,he claims to h us$ x 9 ov] a hundr$ cases ) 8brilliant results10 & cites f\r typical hi/ories4 ,! ,g4 ,w4 ,c>nrick ,company1 :i* manufactures 8,secretog510 an alleg$ secret9 prep>ation1 cites a numb] ( au?orities#gi z also recomm5d+ secret9 = dige/ive disord]s4 ,h>r[]1 :o is or 0 connect$ ) ! ,c>nrick ,company1 9 cl9ical j\rnals#hj has ard5tly advocat$ ! use ( secret9 = a l>ge numb] ( maladies4 #gh ,bev]idge3 ,am4 ,m$4 #bj3bee1 #aiad4 #gi ,lockwood1 ,g4 ,r43 ,diseases ( ,/oma*1 #aiac1 ,*apt] on ,a*ylia4 ,bassl]1 ,an?ony3 ,am4 ,j\r4 ,ga/ro-,ent]41 #aiad2 ,kemp1 ,r4 ,c43 ,diseases ( ,/oma*1 ,inte/9e & ,pancreas1 #aiab4 ,re$1 ,bo>dman3 ,am4 ,j\r4 ,ga/ro-,ent]41 ,octob]1 #aiab4 ,ewald 7,!rapie d] ,geg5w>t1 #aiae1 p4 #e7 reports favorable results ) ,secretog5 9 "o ( ?irte5 cases4 #hj ,h>r[]3 ,p$iatrics #be3dcj1 #aiac2 ,new ,york ,m4 ,j4 #aah3cae1 #aiac2 ,ar*4 f4 ,v]dauungskr4 #bj3egg1 #aiad4 ,,physiologic ,,consid]ations ,?r\gh\t its cl9ical use1 secret9 has be5 giv5 by m\?2 b its direct introduction into ! inte/9e ( a dog "u ane/hesia 9 ev5 enorm\s quantities is )\t effect4 ,?is fact1 fir/ obs]v$ by ,bayliss & ,/>l+1#cb 0 confirm$ by ,fleig1#ha & ,matuso1#cf & our p]sonal exp]im5ts h conv9c$ u ( its tru?4 ,matuso f\nd t ord9>y secret9 & t obta9$ f inte/9al lum5 gave equally negative results4 ,l>ge quantities ( active secret91 moreov]1 acidifi$ to #j4b p] c5t4 hydro*loric acid1 & left 9 ! ileum = fifte5 m9utes1 7 /ill negative4 ,w]!im] & ,duvilli]1#hb 9 a previ\s pap] on ?is subject1 _h likewise f\nd t acid solutions ( secret9 7:i* might be consid]$ m normal = ! inte/9e ?an :5 neutral71 :5 introduc$ into ! ileum gave negative or incon/ant results4 ,!y conclude t x is m likely t ! pancreas does n respond to su* m9imal /imuli1 ?an t ! secret9 is n absorb$4 #ha ,flieg3 ,ar*4 gn4 de md4 #aia3adhb1 #aijc4 #hb ,w]!im] & ,duvilli]3 ,compt4 r5d4 ,soc4 de biol4 #fh3ece1 #aiaj4 ,! de/ructive action ( ! dige/ive enzymes leads u to believe t x is 9 inactive =m t secret9 is absorb$4 ,l ep9ephr91 x _c pass ?r\gh ! dige/ive tract4 ,bayliss & ,/>l+ /ate t x is de/roy$ by "o h\r's tryptic dige/ion4 ,lal\#fb work$ ) ! action on secret9 ( peps91 dog's ga/ric juice1 pancreatic juice1 succus ent]icus & ereps91 & f\nd 9 ea* case a de/ructive effect1 ev5 almo/ aft] mix+2 & aft] five m9utes ov] #ge p] c5t4 ( ! activity _h disappe>$4 ,matuso#cf introduc$ #cj c4c4 ( active secret9 into ! inte/9e1 remov$ x five m9utes lat]1 & f\nd t no activity rema9$4 ,o!r me?ods ( adm9i/ration h be5 tri$4 ,subcutane\s injections are practically negative 7,matuso1#cf ,hallion#hc7 & intrapleural injections are likewise negligible 7,bayliss & ,/>l+#ee74 #hc ,hallion3 ,presse md4 #bj3dcc1 #aiab4 ,/>l+#fc f9ds t cont9u$ intrav5\s injections ( secret9 9 a heal?y dog produces aft] a "t sev]e symptoms ( collapse1 :i*1 he believes1 are due to *ange 9 ! inte/9al muc\s membrane caus$ by ! entry & non-neutralization ( ! /rongly alkal9e pancreatic juice4 ,inte/9al dige/ion seems little affect$ 9 a*ylia ga/rica 7,/ockton1#hd ,ehrman & ,l$]]1#he ,bayliss & ,/>l+#cb74 ,?is may be due to o!r secret9 /imulants z fats1 or to ! action ( ! n]v\s me*anisms 7,meltz]#hf74 #hd ,/ockton3 ,9 ,osi] & ,mc,crae's ,mod]n ,m$ic9e #c3ai1 #aiad4 #he ,ehrman & ,l$]]3 ,deuts*4 m$4 ,w*ns*r4 #ce3hgi1 #aiji4 #hf ,meltz]1 ,s4 ,j43 ,! ,factors ( ,safety 9 ,animal ,/ructure & ,animal ,economy1 ,j4 ,a4 ,m4 ,a41 ,feb4 #bc1 #aijg1 p4 #fee4 ,,! ,,de/ruction ,,( ,,secret9 ,,by ,,human ,,ga/ric ,,juice ,we h c>ri$ out 9 detail exp]im5ts on ! dige/ive effect ( human ga/ric juice on secret94 ,our results 9 e respect confirm ! f9d+s ( ,lal\1#fb :o work$ ) comm]cial peps9 & dog's ga/ric juice1 b are ev5 m /rik+ because ( ! mu* sup]ior quality ( pure human ga/ric juice4 ,me?ods4--,! human ga/ric juice 0 obta9$ f ,mr4 ,v41 ! ga/ric fi/ula case ( our laboratory4 ,! *emical & dige/ive *>act]s ( 8 juice are discuss$ 9 a rec5t pap]4#hg ,9 ! diff]5t exp]im5ts1 diff]5t samples ( ga/ric juice 7 us$4 ,! secret9 employ$ 0 always fre%ly prep>$4 ,dige/ion 0 c>ri$ out 9 ! incubator at #ch ,c4 ) ! reaction ( #j4d p] c5t4 acid1 & ! end ( ! p]iod 0 m>k$ by ei!r boil+ ! mixture or 79 ! fir/ two exp]im5ts7 by turn+ ! mixture alkal9e4 ,! action ( ! prep>ation1 we prov$1 0 n influ5c$ by ! me?od us$4 ,! dogs on :i* ! prep>ations 7 te/$ 7 prep>$ = c>otid blood pressure1 injection into ! ext]nal jugul> ve91 & cannula 9 ! pancreatic duct1 ess5tially ! me?ods ( ,bayliss & ,/>l+#cb be+ employ$4 ,! prep>ations 7 inject$ at body temp]ature aft] be+ neutraliz$ & filt]$4 ,except = ! addition ( normal salt solution in/ead ( ga/ric juice1 ! control injections ( secret9 7 submitt$ to exactly ! same treatm5t z ! o!r prep>ations4 #hg ,c>lson3 ,am4 ,j\r4 ,physiol4 #ch3bdh1 #aiae4 ,results4--,our results are embodi$ 9 ,table #a4 ,we assur$ ourselves be=e beg9n+ ! s]ies t incubation ( secret9 ) boil$ ga/ric juice produc$ no *ange4 ,x is to be not$ 9 ! table t ea* exp]im5t is a unit complete 9 itself1 beg9n+ & end+ ) a control injection ( secret94 ,special att5tion is call$ to ! m>k$ de/ruction t foll[s contact ( human ga/ric juice ) secret9 = m]ely "o m9ute4 ,9 ,exp]im5t #d1 us+ #a c4c4 ( human ga/ric juice1 ! action fell to #ad drops f an orig9al secretion ( #ba2 9 ,exp]im5t #e1 us+ #h c4c4 ( ga/ric juice1 ! action fell to #f drops f an orig9al secretion ( #bj4 ,( int]e/ also is ! rate at :i* we get complete de/ruction ( secret94 ,?is is practically #b h\rs = #b c4c4 ) secret9 giv+ orig9ally #aaj drops 7,exp]im5t #b1 ,fig4 #a71 or #cj m9utes = #e c4c4 ) a secret9 giv+ orig9ally #ec drops 7,exp]im5t #f74 ,^! results are practically p>allel1 ?\gh !y 7 obta9$ ) diff]5t samples ( ga/ric juice & 9 diff]5t exp]im5ts4 ,,table #a4--,,! ,,de/ruction ,,( ,,secret9 ,,by ,,human ,,ga/ric ,,juice ,secretion ( ,pancreatic ,juice 9 ,drops ---------------------------------------- -------------- ,no4 ,quan-#aj ,c4c4c ,! ,secret9 ,aft] ,incubation #aj ,c4c4 ( tity,secret9 ) ,human ,ga/ric ,juice ,secret9 ,exp]-( ,control ---------------------------------,contro l im5t,gas- --,beg9- --,end ( tric n+ ,dig4 ,secre-,dig4 ,secre-,dig4 ,secre-,exp]i- ,juice,exp]i- ,"t1 tion ,"t1 tion ,"t1 tion m5t ,us$1 m5t ,hrs4 ,rate ,hrs4 ,rate ,hrs4 ,rate ,c4c4 ---------------------------------------- -------------------- #a #b #bh #f #j #d #j #b #j #af #b #b #aaj #b #g #a-a_/b #ah #a #ah #da #c #b #dj #a #g #c_/d #g #a_/d #h #ca #d #a #ba #a_/b #aa #a_/d #ab #a_/fj #ad #ah #e #h #bj #a_/b #a #a_/d #c #a_/fj #f #ah #f #e #ec #a_/b #b 44 44 44 44 44 ---------------------------------------- -------------------- ,we also tri$ ! effect ( keep+ ! dige/ive "t con/ant & v>y+ ! am\nt ( ga/ric juice employ$4 ,increas+ ! quantity ( ga/ric juice us$ increases ! quantity ( secret9 de/roy$ 7,table #b74 ,,table #b4--;,,exp]im5t #g99 ,pancreatic ,prep>ation ,juice ,drops #aj c4c4 secret9 #bj #aj c4c4 secret9 dige/$ ) #j4e c4c4 ga/ric juice #ae #aj c4c4 secret9 dige/$ ) #c c4c4 ga/ric juice #ac #aj c4c4 secret9 dige/$ ) #aj c4c4 ga/ric juice #h 99 ,! dige/ive "t 0 kept con/ant at fifte5 m9utes4 7,! ga/ric juice us$ _h be5 dilut$ ) /oma* wa%+s47 ,! read] w obs]ve 9 ,table #a t ! results obta9$ f ! control injection ( secret9 at ! beg9n+ ( ! exp]im5t is uni=mly great] ?an t obta9$ aft] sev]al injections ( dige/$ secret94 ,9 view ( ! e/abli%$ fact t equal quantities ( secret9 c g5]ally be reli$ on to produce results1#ba "o might sugge/ t ! injections ( ! split products ( secret9 h inhibit$ to "s degree ! action ( ! pancreas4 ,we c submit ! data 9 ,table #c 9 support ( ?is view1 %[+ among o!r ?+s t ! action ( secret9 is n influ5c$ by previ\s injections ( in]t depressor sub/ances1 ?\gh x by ! injection ( ! cleavage products ( secret94 7,! v>i\s injections 9 ! exp]im5ts 7 made at ab\t fifte5-m9ute int]vals74 ,we h c>efully analyz$ ! reaction 9 blood pressure t foll[s ! injection ( ! v>i\s prep>ations4 ,we f9d no con/ant effect4 ,dige/$ secret9 gives a fall 9 blood pressure t is at times less1 at times equal1 & at o!r times great] 7,fig4 #a7 ?an t produc$ by ! orig9al prep>ation4 ,besides ! be>+ t x has on ! !rapeutic use ( secret91 ?is de/ructive action ( ! dige/ive enzymes is also ( prime physiologic int]e/4 ,failure to realize x has l$ to misconceptions z to ! intr9sic nature ( secret94 ,,table #c4--;,,exp]im5ts #h ,,& #i ,pancreatic ,prep>ations ,juice ,drops ,exp]im5t #h3 #aj c4c4 secret91 five injections ( in]t depressor sub/ances #bi #aj c4c4 secret91 two injections ( completely dige/$ secret9 #bh #aj c4c4 secret91 eight injections ( in]t depressor sub/ances #af #aj c4c4 secret9 #af ,exp]im5t #i3 #aj c4c4 secret9 7control1 beg9n+ ( exp]im5t7 #ba #aj c4c4 secret91 aft] ?irty m9utes incubation ) #a c4c4 boil$ ga/ric juice #bg #aj c4c4 secret91 aft] ?irty m9utes incubation ) #a c4c4 fre% ga/ric juice #aa #aj c4c4 secret9 7control1 end ( exp]im5t7 #ah ,! f9d+s ( ,lal\1 confirm$ by u1 expla9 ! anomaly t has l$ ,delez5ne#hh to put =w>d ! antisecret9 !ory4 #hh ,delez5ne & ,poz]ski3 ,j\r4 de ,physiol41 #ad3edj1 #aiab4 ,,secret9 ,,has ,,no ,,action ,,:5 ,,giv5 ,,by ,,m\? ,x is a con/ant claim t s _m & complex are ! factors conc]n$ 9 physiologic processes1 t x is n unusual = cl9ical d$uctions to e/abli% !mselves 9 ! face ( a priori laboratory dicta4 ,we consid]$ x desirable1 !re=e1 to te/ ! action ( secret91 orally adm9i/]$1 9 ! mo/ direct mann]1 & ! "o free/ f possible criticism4 ,) ?is 9 view1 we p]=m$ a s]ies ( exp]im5ts on normal unane/hetiz$ dogs hav+ p]man5t pancreatic fi/ulas4 ,me?od4--,9 ! op]ations = p]man5t pancreatic fi/ulas we foll[$ closely ! te*nic develop$ by ,pawl[1#hi & ) excell5t results4 ,! dogs ma9ta9 !mselves 9 spl5did condition if prop] c>e is tak54 ,?is consi/s 9 fe$+ !m only ) bread & milk1 & giv+ sodium bic>bonate daily4 ,! dogs 7 giv5 ?is treatm5t 9 ! ev5+ s t exp]im5tal proc$ure might be c>ri$ on 9 ! day ) empty /oma* "u con/ant conditions4 ,fre%ly prep>$ secret9 9 l>ge quantities 0 giv5 by /oma* tube to ^! dogs1 & ! response ( ! pancreas /udi$ & comp>$ ) ! response obta9$ f control prep>ations4 ,! same prep>ation 0 g5]ally n giv5 on consecutive days4 #hi ,pawl[3 ,ergeb4 de ,physiol41 ,o41 p4 #bff1 #aijb4 ,,table #d4--;,,detail ,,( ,,typical ,,exp]im5ts ,dogs ) pancreatic fi/ulas1 %[+ t secret9 giv5 by m\? has no action on ! pancreas ,rate ( ,secretion ( ,pancreatic ,juice 9 ,c4c4 p] ,hr4 ------------------------------------ ,cont9u\s ,cont9u\s ,secretion ,secretion ,mat]ial ,f$ by ,/oma* ,tube ,be=e ,fe$+ ,aft] ,fe$+ -------------------------------- ,fir/,second,?ird,fir/,second,?ird ,h\r ,h\r ,h\r ,h\r ,h\r ,h\r ---------------------------------------- --------------------- #aej c4c4 active secret91 slightly acid #f4e #c4f #c4i #bj4j #f4j #h4j #aej c4c4 active secret91 slightly alkal9e #ac4j #aa4j #e4j #bc4j #bf4j #ab4j #aej c4c4 secret9 pass$ ?r\gh ,b]kefeld #g4h #g4e #g4d #bc4j #ac4j #aa4j #aej c4c4 extract ( colon #aa4f #ab4j #aa4d #cj4j #ai4f #ad4h #aej c4c4 extract ( ga/ric mucosa #aj4j #g4j #h4j #bc4j #g4e #d4j #aej c4c4 extract ( muscle #f4i #aa4j #f4d #ce4j #e4j #g4j #aej c4c4 #j4d ,h,cl 7dilut$ to #bej c4c47 #f4j #h4j #d4j #cc4j #cf4j #ag4j ---------------------------------------- --------------------- ,results4--,we h data f six dogs ) a total ( sev5ty-six exp]im5ts4 ,z %[n 9 ,table #d1 ! adm9i/ration ( secret9 causes an increase 9 ! fl[ ( pancreatic juice1 b ! adm9i/ration ( in]t sub/ances z extracts ( colon1 ga/ric mucosa or muscle causes a l increase4 ,! activity ( ! secret9 may be r$uc$ to a l[ value by exposure to sunlight1 or filt]+ ?r\gh a ,b]kefeld filt]1 yet ! response ( ! pancreas is n correspond+ly r$uc$4 ,! secretion t occurs 9 ! control cases1 e "o w admit1 is b second>y to ! production ( ga/ric juice ) its accompany+ hydro*loric acid1 t is1 excit$ by virtue ( ! extractives & wat] 9 ! prep>ations4 ,su*1 we c prove1 is ! only action ( secret94 ,a mixture ( gelat91 peptone & salt wat]1 ! *ief incid5tal con/itu5ts ( a secret9 prep>ation1 gives z /rik+ results z ev] obta9$ f secret9 adm9i/ration4 ,yet ! objection may be made t ! response ( ! pancreas t is due to ! incid5tal con/itu5ts ( secret9 is maximal1 & t ! secret9 consequ5tly has no opportunity to display its p>ticul> pot5cy4 ,b1 z inspection ( ! accompany+ tables illu/rate1 ! adm9i/ration ( hydro*loric acid %[s t ! response is by no means maximal4 ,let u cite a /rik+ exp]im5t4 ,= ?ree h\rs be=e ! adm9i/ration ( hydro*loric acid1 ! secretion 9 cubic c5timet]s 0 respectively #bi4d1 #aa4ge & #ce4d c4c42 = ! ?ree h\rs aft]1 respectively #hh4j1 #di4j & #dj4e c4c4 ,illu/ration3 ,fig4 #a4--,trac+s 7r$uc$ two-?irds7 %[+ failure ( ,secretog51 ,elixir ,secretog51 & ,duod59 to /imulate ! fl[ ( pancreatic juice ev5 :5 adm9i/]$ intrav5\sly 9 am\nts ?ree times great] ?an t recomm5d$ to be giv5 by m\?4 ,dog3 light e!r ane/hesia2 cannula 9 ! pancreatic duct2 a1 c>otid blood pressure2 b1 fl[ ( pancreatic juice 9 drops2 c1 signal %[+ :]e ! intrav5\s injections 7 made4 ,trac+ ,a3 ,read+ f left to "r1 ! five intrav5\s injections are3 7#a7 ?ree tablets ( ,secretog5 dige/$ ) #ae c4c4 #j4d p] c5t4 hydro*loric acid & neutraliz$2 7#b7 ?ree tablets ( ,secretog5 boil$ 9 #ae c4c4 #j4d p] c5t4 hydro*loric acid & neutraliz$2 7#c7 ?ree tablets ( ,secretog5 9 #ae c4c4 #j4i p] c5t4 sodium *lorid2 7#d7 ?ree tablets ( ,secretog5 9 #ae c4c4 ( #gj p] c5t4 alcohol2 7#e7 #ae c4c4 ,elixir ,secretog54 ,trac+ ,b3 read+ f left to "r1 ! f\r intrav5\s injections are3 7#a7 #e c4c4 secret9 made fre% f dog's duod5al mucosa2 7#b7 ?ree tablets ( ,duod59 dige/$ 9 #ae c4c4 #j4d p] c5t4 hydro*loric acid & neutraliz$2 7#c7 ?ree tablets ( ,duod59 boil$ 9 #ae c4c4 #j4d p] c5t4 hydro*loric acid & neutraliz$2 7#d7 ?ree tablets ( ,duod59 9 #ae c4c4 sodium *lorid 7#j4i p] c5t474 ,,table #e4--,,summ>y ,,( ,,exp]im5ts ,dogs ) pancreatic fi/ula1 weight #ad kg4 ,secret9 giv5 by m\? ,rate ( ,secretion ( ,pancreatic ,juice 9 ,no4 ( ,c4c4 ,p] ,h\r ,increase ,exp]i- ,mat]ial ,f$ ---------------- 9 m5t ,?ree ,?ree ,c4c4 ,h\rs ,h\rs ,be=e ,aft] ,fe$+ ,fe$+ ---------------------------------------- ------------------------ #c ,secret9 slightly acid #e #aa #f #e ,secret9 slightly alkal9e #bd #cj #f #d ,secret9 pass$ ?r\gh ,b]kefeld #ah #bc #e #a ,secret9 expos$ to sun = #d hrs #af #bi #ac #b ,extract ( colon 7rabbit7 #ai #bi #aj #c ,extract ( ga/ric mucosa #ad #bc #i #c ,extract ( muscle #h #af #h #b ,mixture ( gelat91 peptone & #bc #cc #aj salt #a #a p] c5t4 peptone solution #f #h #b #d #j4b p] c5t4 hydro*loric acid #ac #cg #bd #c ,milk & bread #g #bj #ac ---------------------------------------- ------------------------ ,x is possible by l>ge doses ( sodium bic>bonate giv5 %ortly be=e ! adm9i/ration ( a prep>ation s to depress ! /oma* t x does n respond ) ! usual production ( hydro*loric acid4 ,"u ^! conditions ! adm9i/ration ( secret9 is uni=mly negative1 b ! adm9i/ration ( hydro*loric acid on ! contr>y /ill s]ves to increase ! pancreatic secretion 7,table #f74 ,,table #f4--,,secret9 ,,9 ,,exp]im5tal 8,,a*ylia ,,ga/rica0 ,rate ( ,secretion ( ,pancreatic ,juice 9 ,c4c4 ,p] ,h\r --------------------------------------- ,exp4 ,mat]ial ,f$ ,cont9u\s ,secretion ,secretion ,aft] ,no4 ,be=e ,fe$+99 ,fe$+ ----------------------------------- ,fir/ ,second,?ird ,fir/ ,second,?ird ---------------------------------------- ----------------------- #a #h4g #g4e #f4h #c4j #a4j #d4h #b #aej c4c4 secret9 #d4e #f4e #aj4j #f4j #g4e #g4f #c #ae4f #h4a #af4j #c4i #d4i #b4i #a #aej c4c4 #d ,h,cl #i4h #g4j #f4j #fe4a #bh4j #g4a #b 7dilut$ to #bej c4c47 #ag4d #ah4e #ag4j #cd4j #ah4j #bj4j ---------------------------------------- ----------------------- 99 ,five gm4 ,na ,,hco giv5 at beg9n+ ( ea* fir/ two h\rs4 ,,comm]cial ,,prep>ations ,,( ,,secret9 ,secretog5 & ,elixir ,secretog54--,! ,c>nrick ,company (f]s ,secretog5#ij = use 9 a l>ge numb] ( conditions4 ,! foll[+ indications = ! use ( ! prep>ation purport to be bas$ on cl9ical te/s cov]+ a p]iod ( sev]al ye>s3 dyspepsia1 & ! indige/ions g5]ally1 f]m5tative disord]s1 ga/ric cat>rh1 flatul5ce1 nausea2 pancreatic insuffici5cy1 inte/9al indige/ion2 ga/ric secretory defici5cies1 apepsia2 con/ipation & hepatic torpor2 inte/9al /asis2 di>rhea2 infantile di>rhea1 8summ] compla9t10 m>asmus1 inanition & malnutrition2 ga/ric atony & dilatation2 *olecy/itis & gall/ones2 nephritis1 neura/h5ia1 ca*exia & canc]2 epilepsy & high blood pressure4 ,te/imonials are pres5t$ z to results 9 mo/ ( ^! conditions4 #ij ,secretog51 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry1 ,j4 ,a4 ,m4 ,a41 ,may #a1 p4 #aeah1 #aiae4 ,a quantity ( 8,secretog50 & 8,elixir ,secretog50 0 b\ght 9 ! op5 m>ket1 & ! prep>ations 7 te/$ on suitably prep>$ dogs4 ,! tablets 7 gr\nd1 ?or\ghly mac]at$ ) ! solv5t us$ 7wat]1 normal salt solution1 alcohol1 or #j4d p] c5t4 hydro*loric acid71 & filt]$4 ,if hydro*loric acid 0 us$1 ! pulv]iz$ tablets 7 boil$ ) x1 9 ! mann] t secret9 is made f duod5al mucosa1 & ! prep>ations neutraliz$ previ\s to injection4 ,! injections 7 made 9 f #ae to #bj c4c4 ( ! solv5t4 ,all ! op]ations 7 c>ri$ on imm$iately be=e ! exp]im5t1 & z rapidly z possible1 s z to avoid oxidation4 ,! ,elixir ,secretog5 0 inject$ directly1 )\t dilution4 ,,table #g4--,,summ>y ,,( ,,typical ,,exp]im5ts ,,%[+ ,,! ,,abs5ce ,,( ,,secret9 ,,9 8,,secretog50 ,,& 8,,elixir ,,secretog50 ,,except ,,9 ,,occasional ,,te/s ,,:5 ,,adm9i/]$ ,,9 ,,enorm\s ,,doses ,dogs "u e!r ane/hesia ,secretion ( ,pancreatic ,juice 9 ,drops1 ,quantity ( ,foll[+ ,intrav5\s ,injection ,exp4 ,secretog5 ---------------------------------------- --------- ,no4 & ,elixir ,secretog5 9 ,secretog5 ,control ------------------------ ,control ,us$99 #aj ,c4c4 ,di/ill$#j4d #gj #j4i;,elixir#aj ,c4c4 ,secret9 ,wat] ,h,cl ,alcohol,na,cl ,secret9 ---------------------------------------- ----------------------- #a ,secretog51 #a tablet2 #aji #j #j #j #j #j #ei ,elixir1 #ae c4c4 #a ,secretog51 #f tablets 444 44 #j 44 44 44 44 #b ,secretog51 #c tablets2 #af #j #j #j #j #a787 #af ,elixir1 #ae c4c4 #c ,secretog51 #e tablets 444 44 #a787 44 44 44 44 #d ,secretog51 #be tablets #ad 44 #a787 44 44 44 #h #e ,secretog51 #ajj tablets #aaj 44 44 44 #ba 44 #fg #f ,secretog51 #ajj tablets2 #ai 44 #e 44 #a #b787 #h ,elixir1 #abe c4c4 #g ,elixir1 #ej c4c4 444 44 44 44 44 #a787 44 ---------------------------------------- ----------------------- 99 ,"o to ?ree tablets is 7accord+ to ! label7 ! !rapeutic dose ( ,secretog52 #d to #ab c4c4 ! dose ( ,elixir ,secretog54 ,results4--,9 only "o case 0 a slight response obta9$1 ! o!rs gave none4 ,small & l>ge doses 7 equally in]t 7,table #g1 ,figs4 #b1 #c74 ,! prep>ations1 ?\gh in]t1 always produc$ a depression 9 blood pressure1 sometimes ev5 great] ?an t caus$ by active secret94 ,among our _m te/s1 "o bottle 0 f\nd1 h[ev]1 to be a little diff]5t f ! re/ 7,exp]im5t #d74 ,its entire cont5t1 #ajj tablets1 _h be5 gr\nd & boil$ 9 #j4i p] c5t4 sodium *lorid4 ,! extract on injection 0 f\nd to h a small b unmi/akable secret9 reaction1 equival5t to ab\t #b c4c4 ( ! control secret9 us$4 ,b repeat$ exp]im5ts 7 unable to duplicate ?is result4 ,! 8,secretog50 & 8,elixir ,secretog50 7 all suppos$ly fre% prep>ations1 ! retail drug /ore in=m+ u t a fre% supply 0 obta9$ f ! :olesale h\se ea* week4 ,secretog51 !n1 conta9s practically no secret91 & ev5 if x did conta9 secret91 x c h no effect on ! pancreas :5 tak5 by m\?4 ,! indications = ,secretog51 !re=e1 are bas$ on false premises1 & ! te/imonials are wor?less4 ,illu/ration3 ,fig4 #b4--,trac+s 7r$uc$ "o-half7 %[+ no /imulation ( ! pancreas by ,secretog51 ,elixir ,secretog51 & ,duod591 ev5 :5 adm9i/]$ intrav5\sly 9 quantities "o hundr$ times great] ?an ! !rapeutic dose by m\?4 ,dog3 ,light e!r ane/hesia2 cannula 9 ! pancreatic duct2 a1 c>otid blood pressure2 b1 fl[ ( pancreatic juice 9 drops4 ,trac+ ,a3 at x1 intrav5\s injection ( #aj c4c4 secret9 prep>$ f duod5al mucosa ( dog4 ,trac+ ,b3 at x1 intrav5\s injection ( #ajj tablets ( ,secretog5 dige/$ ) #j4d hydro*loric acid & neutraliz$4 ,trac+ ,c3 at x1 intrav5\s injection ( #ajj tablets ( ,secretog51 prep>$ z 9 ,trac+ ,b4 ,trac+ ,d3 at x1 intrav5\s injection ( #ej c4c4 ,elixir ,secretog54 ,trac+ ,e3 at x1 intrav5\s injection ( #ajj tablets ( ,duod59 7dissolv$ 9 #j4i p] c5t4 sodium *lorid74 ,duod594--,?is is a prep>ation manufactur$ by ,arm\r ,company1 :i* purports to be 8secret9 plus ent]ok9ase40 ,! claims = ?is product are simil> to ^? = ,secretog51 b some:at less sweep+4 ,accord+ to ! manufactur]s1 8,duod59 7,arm\r7 is recomm5d$ 9 ! treatm5t ( inte/9al disord]s :]e an increas$ fl[ ( pancreatic1 hepatic & inte/9al secretion is desir$4 ,x is ( specific value 9 proteid dige/ion on ! !ory t secret9 & ent]ok9ase /imulate ! pancreas & activate its secretion40 ,illu/ration3 ,fig4 #c4--,trac+s 7r$uc$ "o-half7 %[+ practically complete de/ruction ( secret9 by ! ga/ric juice4 ,dog "u light e!r ane/hesia2 cannula 9 ! pancreatic duct2 a1 c>otid blood pressure2 b1 record ( fl[ ( pancreatic juice 9 drops4 ,"t1 tw5ty-five m9utes4 ,trac+ ,a3 intrav5\s injection ( #aj c4c4 secret9 7prep>$ fre% f dog's duod5al mucosa7 at x4 ,trac+ ,b3 intrav5\s injection 7at x7 ( #aj c4c4 ( ! same secret9 z 9 ,trac+ ,a1 aft] be+ dige/$ 9 normal human ga/ric juice at #cg ,c4 = two h\rs4 ,we b\ght a quantity ( ,duod59 9 ! op5 m>ket1 & c>ri$ out on ?is product ! same s]ies ( exp]im5ts z t us$ 9 ! case ( ,secretog54 ,! results 7 simil>ly negative 7,table #h74 ,,table #h4--,,summ>y ,,( ,,typical ,,exp]im5ts ,,%[+ ,,! ,,abs5ce ,,( ,,secret9 ,,9 8,,duod590 ,dogs "u e!r ane/hesia ,secretion ( ,pancreatic ,juice 9 ,drops1 ,foll[+ ,intrav5\s ,injection ,exp4 ,numb] ---------------------------------------- --------- ,no4 ,duod59 ,control ,duod59 9 ,control ,tablets #aj ,c4c4---------------------------- #aj ,c4c4 ,us$ ,secret9,di/ill$ #j4d #gj #j4i ,secret9 ,wat] ,h,cl ,alcohol ,na,cl ---------------------------------------- ------------------ #a #c #bi #j #j #j #a787 #bh #a #f 444 44 #a787 44 44 44 #b #ah #af 44 #f 44 44 #af #c #e #ad 44 #j #j #j #h #c #be 444 44 #a787 44 44 44 #d #ajj #aaj 44 #j 44 44 #fg #e #aej #ai 44 #j 44 #j #h ---------------------------------------- ------------------ ,9 reg>d to bo? ,secretog5 & ,duod591 we assume t ! manufactur]s h tri$ to put secret9 9 !m1 b h be5 unable because !y h fail$1 9 all likelihood1 to *eck _! me?ods by physiologic /&>dization4 ,^! firms d n give any details z to ! proc$ure !y employ$ 9 _! manufacture ( secret94 ,desiccat$ secret9 ( extreme pot5cy has be5 prep>$ by v>i\s physiologi/s1#ia #a mg4 7#a_/fd gra97 ( :i* is active :5 giv5 intrav5\sly4 ,x is difficult to conceive t any ( ^! me?ods 7 us$ 9 ! prep>ation ( ,secretog5 or ,duod594 #ia ,/epp 7,note #ac74 ,dale & ,laidl[3 ,j\r4 ,physiol4 #dd3aa1 #aiab4 ,launoy & ,o*sl93 ,comp4 r5d4 ,soc4 de biol41 #gd3cch1 #aiac4 ,,conclusions #a4 ,secret9 is quickly de/roy$ by ga/ric juice & by tryps94 #b4 ,secret9 is n absorb$ 9 active =m f ! alim5t>y tract4 #c4 ,! pres5ce ( secret9 or prosecret9 _c be demon/rat$ 9 ! comm]cial prep>ations 8,secretog510 8,elixir ,secretog50 & 8,duod590 ev5 :5 ! !rapeutic dose ( ! prep>ations is giv5 intrav5\sly4 ,9 ! case ( 8,secretog510 intrav5\s injection ( #ajj times ! !rapeutic dose reveals occasionally an insignificant trace ( secret94 ,,discussion ,,( ,,results ,x is1 ( c\rse1 objectionable t prep>ations conta9+ no secret9 %\ld be adv]tis$ to ! m$ical pr(ession z conta9+ ?is sub/ance4 ,! m important blund]1 h[ev]1 consi/s 9 ! attempt to (f] su* prep>ations = oral adm9i/ration1 because ev5 *emically pure secret9 w\ld be equally ineffective :5 tak5 by m\?4 ,!re is z yet no reliable evid5ce t lack ( secret9 is a prim>y or important factor 9 any disease4 ,ev5 %\ld ?is be e/abli%$1 secret9 !rapy1 to be effective1 mu/ be intrav5\s4 ,secret9 has n yet be5 prep>$ 9 suffici5tly pure /ate to r5d] possible intrav5\s injection 9 man )\t injuri\s effects4 ,& ev5 :5 ?is has be5 atta9$1 ! v fleet+ action ( secret9 w 9 all probability r5d] secret9 !rapy z futile 9 all ! diseases 9 :i* x is !oretically indicat$ z ep9ephr9 !rapy is 9 ,addison's disease4 ,b !re rema9s ! alleg$ favorable effect f secret9 !rapy by m\? 9 v>i\s diseases 9 man4 ,x is1 p]haps1 imp]t95t = laboratory m5 to comm5t on ^! cl9ical results4 ,! ord9>y 8te/imonials0 ne$ n be consid]$1 b we %\ld l to ask ! s]i\s work] :o ?9ks he has actually obta9$ good results f secret9 !rapy h[ c]ta9 he is ( ! causal relation betwe5 ! giv+ ( secret9 or alleg$ secret9 & ! abatem5t ( ! disease4 ,:5 a !rapeutic measure n only lacks a positive basis 9 physiology & pa?ology b runs contr>y to all ! well-e/abli%$ exp]im5tal facts 9 ^! fundam5tal m$ical sci5ces1 is x too mu* to ask t positive cl9ical f9d+s be subject$ to m ?an usual critical analysis be=e acceptance8 8,cl9ical te/s10 x is said1 8cov]+ a p]iod ( sev]al ye>s h prov$ t nei!r ! condition 9 ! /oma* dur+ dige/ion nor ^? 9 ! inte/9e prev5t ! secret9 f ent]+ intact into ! circulation40 ,:5 we meet claims su* z ?is1 %\ld we n scrut9ize ! 8te/s0 z well z ! m5 :o make !m8 ,we are indebt$ to ,dr4 ,j4 ,h4 ,moorehead = assi/ance 9 "p ( ! surgical "w4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #ae1 #aiaf47 ,,articles ,,refus$ ,,recognition ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,bel[ appe> ab/racts ( ! ,c\ncil's action on articles refus$ recognition :i* 7 n deem$ ( suffici5t importance to require l5g?y reports3 ,radio-,rem ,! ,radium ,!rapy ,company1 ,s*ieffel9 ,co41 sell+ ag5ts1 submitt$ to ! ,c\ncil radium emanation g5]ators call$ 8,radio-,rem ,outfits10 design$ to g5]ate respectively #bjj1 #a1jjj1 #b1jjj1 #e1jjj & #aj1jjj ,ma*e units p] tw5ty-f\r h\rs4 ,^? :o are well in=m$ on ! subject ( radium !rapy are ( ! op9ion t ! adm9i/ration ( small am\nts ( radium emanation su* z g5]at$ by c]ta9 outfits is )\t !rapeutic value4 ,x has be5 /at$ t at ! ,radium ,in/itute ( ,london ! m9imum prelim9>y dose is #ahe microcuries 7#ejj1jjj ,ma*e units71 & z _m z #eee microcuries 7#a1ejj1jjj ,ma*e units7 are employ$4 ,9 consid]ation ( ^! facts ! ,c\ncil vot$ n to accept any radium emanation g5]ator :i* produces less ?an #b microcuries ( emanation dur+ tw5ty-f\r h\rs4 ,accord+ly1 :ile accept+ ,radio-,rem ,outfit ,no4 #e1 claim$ to produce #aj1jjj ,ma*e units 7#c4g microcuries7 & ,radio-,rem ,outfit ,no4 #d1 claim$ to produce #e1jjj ,ma*e units 7#a4h microcuries71 ! ,c\ncil vot$ n to accept ,radio-,rem ,outfit ,no4 #c1 claim$ to produce #b1jjj ,ma*e units 7#j4gd microcurie71 ,radio-,rem ,outfit ,no4 #b1 claim$ to produce #a1jjj ,ma*e units 7#j4cg microcurie71 & ,radio-,rem ,outfit ,c1 claim$ to produce #bjj ,ma*e units 7#j4jg microcurie74 ,?is report hav+ be5 submitt$ to ,s*ieffel9 ,co4 & _! reply consid]$1 ! ,c\ncil au?oriz$ publication ( ! report4 ,see also ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiaf1 p4 #fca4 ,olio-,phlogosis ,olio-,phlogosis1 a liquid prep>ation to be appli$ ext]nally by means ( a cotton pad1 is adv]tis$ by ! ,my/ic ,*emical ,company1 ,kansas ,city1 ,mo41 ?us3 8,doctor3 ,don't fail to use ,olio-,phlogosis lib]ally = ,pneumonia1 ,bron*itis & ,pleurisy4 ,x works quickly4 ,olio-,phlogosis is z f> ahead ( all m$icat$ kaol9 pla/]s z ^! pla/]s 7 ahead ( ! old-"t moi/ & soggy p\ltices40 ,a pamphlet advises ! use ( ,olio-,phlogosis 9 8444 all cases ( ,inflammation & ,conge/ion1 su* z ,pneumonia1 ,bron*itis1 ,pleurisy1 ,cr\p1 ,boils1 ,c>buncles1 ,rheumatism1 ,swoll5 ,gl&s1 ,p]itonitis1 ,ov>itis1 z a ,surgical ,dress+1 ,mamitis ,ma/itis 787 ,vag9itis & ,metritis 7on cotton tampon to deplete ^! p>ts71 ,septic ,w\nds1 ,old ,ulc]s1 ,*ilbla91 ,eczema1 ,neuralgia1 ,inflammation ( ! ,eyes & ,e>s1 ,alveol> ,inflammation1 ,burns1 ,scalds1 ,etc40 ,accord+ to ! in=mation s5t to ! ,c\ncil by ! ,my/ic ,*emical ,company1 ,olio-,phlogosis has ! foll[+ composition p] gallon3 ,ol4 ,eucalyptus ,gaul!ria drs4 #h ,ol4 ,abies ,canad5sis drs4 #h ,ol4 ,abies ,canad5sis drs4 #b ,ol4 ,?yme 7:ite7 drs4 #b ,resublimat$ ,iod9 cry/als grs4 #cb ,resorc9 drs4 #a ,acid ,boracic ,c4 ,p4 drs4 #b ,qu99e ,bisulphate drs4 #d ,sodium ,?iosulphate drs4 #c-a_/b ,glyc]9 ,c4 ,p4 q4 s4 ad gal4 #a ,a nonquantitative =mula :i* appe>s on ! label ( a sample bottle s5t to a physician enum]ates ! same +r$i5ts except ! sodium ?iosulphate4 ,! ,a4 ,m4 ,a4 ,*emical ,laboratory reports t no free iod9 c\ld be detect$ 9 ! prep>ation4 ,app>5tly1 !n1 ,olio-,phlogosis is ess5tially a sk9 irritant appli$ by means ( cotton2 x c be expect$ to be j ab\t z effective z ! old-fa%ion$ cotton pneumonia jacket1 us$ 9 conjunction ) an aromatic sk9 irritant1 su* z camphorat$ oil or w9t]gre5 or m5?ol o9tm5t4 ,! odor may h "s psy*ic effect1 & x is possible t "s ( ! oily matt] may be absorb$ by ! sk94 ,t su* small am\nts1 ev5 if absorb$1 c produce any consid]able sy/emic effect1 h[ev]1 is highly improbable1 & ! advice t ?is prep>ation be reli$ on 9 pneumonia1 pleurisy1 p]itonitis1 etc41 is p]nici\s4 ,9 ! few cases ( pneumonia 9 :i* heat is indicat$1 ! pla9 cotton pad w usually be f\nd suffici5t4 ,if ! physician consid] ! addition ( a sk9 irritant desirable1 x is easy to select "o f ! (ficial prep>ations4 ,x w be f> m rational to d s ?an to invoke ! aid ( a my/ic "n & a complex =mula to :i* ! pati5t & 8 family1 at lea/1 w be l$ to give unm]it$ cr$it4 ,! claims made = ,olio-,phlogosis are unw>rant$2 its composition is complex & irrational1 & ! nondescriptive b !rapeutically sugge/ive "n is likely to lead to uncritical use4 ,! ,c\ncil vot$ t ! product be refus$ recognition = conflict ) ,rules #f1 #h & #aj1 & t ?is report be publi%$4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,aug4 #ai1 #aiaf47 ,,! ,,hypophosphite ,,fallacy ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has adopt$ ! foll[+ report & au?oriz$ its publication4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,! introduction ( hypophosphites into m$ic9e 0 due to an errone\s & n[ disc>d$ !ory z to ! cause ( tub]culosis ( :i* "o ,dr4 ,j4 ,f4 ,*ur*ill ( ,london1 & lat] ( ,p>is1 0 ! promulgator & propag&i/4#ib ,?is !ory 0 t ! s-call$ 8tub]culosis dia!sis0 0 due to a defici5cy ( phosphorus 9 ! blood4 ,believ+ t ! hypophosphites1 :ile nontoxic1 7 capable ( fur!r oxidation 9 ! organism1 ,*ur*ill recomm5d$ !m z ! be/ means ( supply+ ! suppos$ly lack+ phosphorus4 ,x is n[ kn[n t tub]culosis is n due to a defici5cy ( phosphorus4 ,( m importance is ! fact1 n[ kn[n1 t little phosphorus1 if any1 is assimilat$ f ! hypophosphites--f> less ?an f phosphorus comp\nds ( ord9>y food4#ic ,!re is no ju/ification = giv+ hypophosphites = ! sake ( _! phosphorus cont5t4 ,= v>i\s reasons1 h[ev]--p>tly f =ce ( habit & p>tly because ( ! p[] ( adv]tis+--_m physicians /ill prescribe hypophosphite prep>ations1 & consequ5tly1 !y are /ill includ$ 9 ! ,ph>macopeia & 9 textbooks on mat]ia m$ica & !rapeutics4 ,!y are put out 9 ! =m ( 8specialties0 & ( propriet>y prep>ations1 & are laud$ extravagantly by ! manufactur]s ( ! latt]4 #ib ,*ur*ill1 ,j4 ,f43 ,de la cause immdiate et du traitem5t spcifique de la ph?isie pulmonaire et des maladies tub]culeuses1 ,p>is1 #aheh4 #ic ,! ,hypophosphite ,fallacy1 ,j4 ,a4 ,m4 ,a41 ,april #be1 #aiad1 p4 #acdf4 ,al?\gh ! ov]:elm+ weight ( evid5ce 0 aga9/ ! probability t ! hypophosphite prep>ations are ( value z !rapeutic ag5ts1 ! ,c\ncil ?\ght x well to inve/igate ! subject4 ,dr4 ,w4 ,mc,kim ,m>riott ( ,baltimore 0 !re=e reque/$ to review ! evid5ce = & aga9/ ! !rapeutic usefulness ( ! hypophosphites & to conduct su* exp]im5ts z seem$ necess>y4 ,8 report has already appe>$ 9 ,! ,j\rnal4#id #id ,m>riott1 ,w4 ,mc,kim3 ,! ,!rapeutic ,value ( ! ,hypophosphites1 ,j4 ,a4 ,m4 ,a41 ,feb4 #ab1 #aiaf1 p4 #dhf4 ,dr4 ,m>riott f\nd t n9e obs]v]s 7,paquel9 & ,joly1 ,v]meul51 ,bodda]t1 ,massol & ,gamel1 ,panz]1 ,dela9i & ,b]g71 :o endeavor$ to te/ ! alleg$ utilization ( ! hypophosphites 9 ! organism1 report$ t !re is complete1 or practically complete1 elim9ation ( hypophosphites 9 ! ur9e1 ) little or no effect on ! body4 ,only "o exp]im5t] 7,patta7 claim$ t a consid]able am\nt ( +e/$ hypophosphite 0 reta9$ 9 ! body2 h[ev]1 he us$ a me?od n[ kn[n to be inaccurate & made obvi\s errors 9 calculation1 s t 8 conclusions 7 unw>rant$4 ,s9ce ! evid5ce 0 ev5 to ?is ext5t contradictory1 ,m>riott p]=m$ a s]ies ( exp]im5ts4 ,! me?ods ( ?is /udy & details ( results are describ$ 9 8 pap]1 9 :i* he also discusses ! exp]im5ts ( "s o!r obs]v]s4 ,m>riott writes3 8,none ( ! subjects ( ! exp]im5t ,m>riott's exp]i5c$ any effect :atsoev] f ! adm9i/ration ( ! drug4444 ,almo/ all ( ! +e/$ hypophosphite is promptly elim9at$ un*ang$4444 8,^! exp]im5ts ,=bes' demon/rate conclusively t ! hypophosphites possess no specific value z a s\rce ( phosphorus = ! body4 ,?is is n to be wond]$ at 9 view ( ! fact t #he p] c5t4 ( ! phosphorus +e/$ 9 ! =m ( hypophosphite is excret$ un*ang$1 & !re is no pro( t ev5 ! rema9+ #ae p] c5t4 is available to ! organism4 ,x is d\btful if !re are any conditions 9 :i* ! body suff]s f lack ( phosphorus4 ,ev5 %\ld su* conditions exi/1 phosphorus1 9 ! =m t x occurs 9 ! ord9>y foods1 or z phosphates1 is m effici5t 9 supply+ ! deficit ?an hypophosphites t mu/ be oxidiz$ be=e utilization & :i* are only ab\t #ae p] c5t4 oxidiz$1 if at all4 ,= example1 half a glass ( milk conta9s m available phosphorus ?an ?ree l>ge doses ( hypophosphites ( #ae gra9s ea*1 z great a dosage z is usually giv54 8,:at1 !n1 is ! !rapeutic value ( hypophosphites8 ,!re is no reliable evid5ce t !y ex]t a physiologic effect2 x has n be5 demon/rat$ t !y influ5ce any pa?ologic process2 !y are n #8foods4' ,if !y are ( any use1 t use has nev] be5 discov]$40 ,9 view ( ! =ego+1 x seem$ to ! ,c\ncil advisable to exam9e ! claims "u :i* a few ( ! propriet>y hypophosphite prep>ations are m>ket$4 ,! foll[+ are repres5tative3 ,,fell[s' ,,syrup ,,( ,,hypophosphites ,no v exact in=mation conc]n+ ! composition is furni%$ by ! manufactur]s 7,fell[s ,m$ical ,mfg4 ,co41 ,new ,york74 ,!y say t ! product 8444 conta9s ! *emically pure hypophosphites ( iron1 qu991 /ry*n91 calcium1 manganese & potassium1 agreeably bl5d$ 9 ! =m ( a bl&1 /able syrup ) a slightly alkal9e reaction4444 8,ea* fluid dra*m conta9s ! equival5t ( #a-fd? ( a gra9 ( pure /ry*n940 ,! ,fell[s' ,hypophosphites adv]tis+ furni%es some?+ l a b>omet] ( ! popul> /atus ( hypophosphites4 ,9 "o circul> 7undat$1 b1 f c]ta9 ref]5ces conta9$ 9 x1 presumably issu$ t5 or fifte5 ye>s ago7 we read3 8,x is an indubitable fact t ! hypophosphites h e>n$ ! di/9ction ( hav+ _! !rapeutic value m completely e/abli%$ ?an h any o!r rem$ial ag5ts4444 x is only by accept+ ! curr5t view1 :i* 0 orig9ally advanc$ by ,mr4 ,fell[s1 t we c satisfactorily acc\nt = ! inconte/able fact t ! hypophosphites are ( supreme importance 9 ! treatm5t ( a v ext5sive v>iety ( affections4444 ! hypophosphites increase ! consumption ( oxyg5 & ! elim9ation ( c>bon dioxide4 ,9 ?is mann]1 !y /imulate nutrition & promote con/ructive metamorphosis4444 ,x is n[ univ]sally conc$$ t ! widespread utility ( ! hypophosphites is due to ! fact t !y sub/antially improve metabolic processes1 ?us increas+ ! disease-resi/+ capacity ( all ! tissues40 ,! circul>1 cont9u+1 emphasizes ! 8incomp>able phosphorus-contribut+ prop]ties0 ( ,fell[s' ,syrup1 its 8extraord9>y recon/ructive prop]ties0 & 8! magnific5t results :i* inv>iably att5d its employm5t 9 ! treatm5t ( anemia1 *ronic bron*itis1 *lorosis1 neura/h5ia1 mollities ossium1 delay$ union ( fractures1 rickets1 convalesc5ce10 etc4 ,a circul> be>+ ! copyright date #aiad1 on ! o!r h&1 admits t3 8,! !ories = ! favorable action ( ,fell[s ,syrup ( ,hypophosphites h und]gone sev]al *anges40 ,! same circul> fur!r ma9ta9s1 h[ev]1 t3 8444 ! fact has nev] be5 *all5g$ t 9 ,fell[s ,syrup ( ,hypophosphites we h "o ( ! mo/ effici5t1 mo/ complete1 mo/ all-ar\nd tonics & roborants 9 ! mat]ia m$ica40 ,no attempt is made to base ?is ass]tion on ! !rapeutic action ( ! con/itu5ts4 ,9 o!r words1 ! old !ory1 :i* =m$ ! basis = ! popul>ity ( ,fell[s' ,syrup1 has be5 ?r[n ov]bo>d1 b no sub/itute is deem$ necess>y2 ! mom5tum already acquir$ is app>5tly reg>d$ z suffici5t to insure its cont9u$ sale4 ,fell[s' ,syrup ( ,hypophosphites is a semisecret1 unsci5tific prep>ation--an affront to s\nd !rapy--exploit$ by means ( extravagant & mislead+ /atem5ts4 ,,syrupus ,,roborans 7,,syrup ,,hypophosphites ,,comp4 ,,) ,,qu991 ,,/ry*n9 ,,& ,,manganese7 ,little in=mation conc]n+ ?is prep>ation seems to be furni%$ at pres5t by ! manufactur]s1 ,ar?ur ,pet] ,co41 ,l\isville1 ,ky4 ,accord+ to an old circul>1 x conta9s1 9 ea* fluid\nce1 ,gra9s 8,hypophos4 ,potass4 #a-a_/b ,hypophos4 ,manganese #a ,hypophos4 ,lime #a ,hypophos4 ,iron #a-a_/b ,hypophos4 ,qu99 #f_/af ,hypophos4 ,/ri*n9 #a_/af 8#a_/abh gra9 ,/ry*nia to ,teaspoonful40 ,fur!r1 accord+ to ! same circul>3 8,! ,hypophosphites are especially useful 9 all diseases :]e !re is a lack ( nutrition4444 ,!y are ! be/ ( all rem$ies 9 ,ra*itis1 non-union ( fractures1 ,o/eomalacia & ,syphilitic ,p]io/itis40 ,z = ,syrupus ,roborans itself3 8,?is elegant prep>ation is 444 ! be/ g5]al tonic & recon/ructive kn[n40 ,! unw>rant$ !rapeutic claims =m]ly made = x seem to be no long] circulat$4 ,syrupus ,roborans is an unsci5tific1 %otgun mixture4 ,,s*lott]beck',s ,,solution ,,hypophosphites ,,( ,,lime ,,& ,,soda 7,,liq4 ,,hypophosphitum1 ,,s*lott]beck',s7 ,! ,s*lott]beck ,foss ,co41 ,portl&1 ,ma9e1 ! manufactur]s1 say ( _! prep>ation3 8,?is solution conta9s #cj gra9s ( ! comb9$ ,hypophosphites ( ,lime & ,soda to ! ounce4 ,x conta9s ,no ,sug>1 ,no ,acid & x is ,p]fectly ,neutral40 8,indications = use4--,galacto/asis1 ,imp]fect ,metabolism1 ,neura/h5ia1 ,n]v\s ,dyspepsia1 ,insomnia1 ,convalesc5ce1 ,acetonuria1 ,cyclic ,vomit+ 9 ,infants1 ,diabetes1 ,/>vation1 ,defici5cy ( ,lime1 ,"m's ,tee? dur+ ,pregnancy1 ,d5tition ( ,infants1 ,ra*itis1 ,furunculosis1 ,vomit+ ( ,pregnancy1 ,obesity40 8,migra9e is (t5 caus$ by conditions = :i* ?is ,solution is "o ( ! mo/ satisfactory rem$ies30 8,9 ,insomnia due to advanc+ age1 x w (t5 act z a hypnotic44440 ,( ! hypophosphites ! ,s*lott]beck ,foss ,company say3 8,if #8damn+ x ) fa9t praise' on ! "p ( "s ( ! lead+ m$ical au?orities1 or utt]ly condemn+ x z useless1 on ! "p ( o!rs1 w\ld kill a m$ic9e1 ! ,hypophosphites w\ld long s9ce h disappe>$ z m$ic9al ag5ts4 ,negative te/imony 9 reg>d to ! value ( a drug does n settle any?+40 ,( _! own prep>ation !y say3 8,:5 we get ! results t ought to foll[ ! adm9i/ration ( ,hypophosphites1 we h prov$ t ,s*lott]beck's ,solution ent]s ! sy/em un*ang$40 8,?is ,solution is prim>ily a blood & n]ve tonic & *emical food40 ,s*lott]beck's ,solution ( ,hypophosphites ( ,lime & ,soda is a semisecret prep>ation m>ket$ "u claims t are bo? unw>rant$ & mislead+4 ,,rob9son',s ,,hypophosphites ,accord+ to ! manufactur]s1 ! ,rob9son-,pettet ,company1 ,l\isville1 ,ky41 ea* fluid\nce ( ?is prep>ation conta9s3 8,hypophosphites ,soda #b gr4 ,hypophosphites ,lime #a-a_/b gr4 ,hypophosphites ,iron #a-a_/b gr4 ,hypophosphites ,qu99 #c_/d gr4 ,hypophosphites ,/ry*n9e #a_/af gr40 ,x is claim$ to be 8,nutritive1 ,tonic ,alt]ative4 ,a ,/&>d ,rem$y 9 ! treatm5t ( ,pulmon>y ,ph?isis1 ,bron*itis1 ,scr(ul\s ,ta9t1 ,g5]al ,debility1 etc4 ,/imulates ,dige/ion1 promotes ,assimilation40 ,! decl>$ composition ( ! prep>ation is unsci5tific1 & ! !rapeutic claims are unw>rant$4 ,,eupeptic ,,hypophosphites ,nelson1 ,bak] ,co41 ,detroit1 ,mi*41 :o m>ket ,eupeptic ,hypophosphites1 call ?is prep>ation3 8,a sup]ior comb9ation conta9+ ! ,hypophosphites ( ,potassium1 ,calcium1 ,iron & ,manganese1 & ! bitt] tonics1 ,qu99 & ,/ry*n91 agreeably associat$ ) natural dige/ive f]m5ts ( ! pancreatic secretion4 ,x is ?us a g5]al recon/ructive tonic4444 ,! rem$y is ( especial value 9 ! treatm5t ( m5tal & n]v\s affections4444 ,x is indicat$ 9 pulmon>y tub]culosis1 9 all wa/+ diseases1 9 debilitat$ conditions g5]ally & 9 all exhau/ion f ov] "w40 ,on ! basis ( ! manufactur]'s /atem5t1 ,eupeptic ,hypophosphites mu/ be reg>d$ z a semisecret1 unsci5tific1 %otgun prep>ation1 exploit$ ?r\gh unw>rant$ !rapeutic claims4 ,,mc>?ur',s ,,syrup ,,( ,,! ,,hypophosphites ,,comp4 7,,lime ,,& ,,soda7 ,s f> z ! rec5t lit]ature & trade package are conc]n$1 no in=mation z to ! composition ( ?is product is furni%$ beyond :at is convey$ 9 ! "n4 ,! adv]tis+ = ,mc,arthur's ,syrup1 l t = ,fell[s' ,syrup & ,pet]s' ,syrupus ,roborans1 has be5 modifi$ z "t has pass$4 ,a few ye>s ago x 0 adv]tis$ "u su* claims z ! foll[+3 8444 ,has ,/ood ! ,te/ dur+ _m ye>s = unequal$ efficacy 9 ! treatm5t ( ,tub]culosis4444 ,indicat$ also z a ,tonic & ,tissue ,build] 9 convalesc5ce f ,fev]s1 9 ,n]v\s ,diseases1 ,rickets1 ,s5ile ,debility & ,bron*itis40 8,its use is indicat$ 9 444 diseases ( ! *e/1 *ronic c\gh1 ?roat affections1 g5]al debility1 bra9 exhau/ion1 *ol]a infantum & wa/+ diseases ( *ildr540 ,at pres5t no def9ite claims seem to be made = x2 ! manufactur]s evid5tly f9d ! magic "n ( hypophosphites suffici5t to evoke ! spell = :i* ! adv]tisem5t writ]'s aid 0 once s\ght4 ,a te/imonial conta9$ 9 a circul> :i* seems to be /ill us$ illu/rates bo? ! k9d ( aura :i* surr\nds hypophosphites 9 ! m9ds ( physicians :o are /ill liv+ 9 ! pa/1 & ! k9d ( logic :i* has made ! reputation ( ?is & _m o!r equally wor?less prep>ations4 8,j ab\t six ye>s ago ,i _h a sev]e attack ( ,la ,grippe :i* almo/ kill$ me4 ,left me ) ,a/hma 7,cat>rh7 & a sev]e c\gh4 ,did n get out ( ! h\se = ?ree mon?s4 ,took ov] a doz5 bottles ,mc,arthur's ,hypophos4--came out all "r & s9ce !n work$ h>d1 b la/ ,fall took ano!r cold1 b work$ on1 us$ ,mc,arthur's ,hypophos41 am us+ x n[1 am on my #ab? bottle4 8,i h five or six pati5ts :om ,i h put on ,mc,arthur's ,hypophos41 b ,i d n prescribe ! s+le bottle1 b :olesale no less ?an half doz5 bottles4 ,"o pati5t is on 8 #bd? bottle ) ord]s to get ano!r half doz5 & keep x up all w9t]4 ,i h giv5 ! same ord] to all 7keep x up all w9t]7 & ,i myself int5d to d ! same1 = ) its use ,i h lo/ no "t--ra9 or %9e ,i am do+ my "w4 ,i "k :at x has done = me & :at x is do+ = my pati5ts40 ,x w\ld be h>d to f9d a m *>act]i/ic example ( ! nave m5tal processes ( ! simple folk :o 9 all good fai? write te/imonials = wor?less m$ic9es4 ,?is well-mean+ practition] 7a homeopa?1 by ! way71 because he 8came out all "r0 aft] an attack ( grip1 returns all praise to ,mc,arthur's ,hypophosphites1 :i* he has tak5 8:olesale40 ,n ! fa9te/ d\bt ( ! validity ( 8 po/ hoc ergo propt] hoc argum5t seems to glimm] across 8 consci\sness4 ,mc,arthur's ,syrup ( ! ,hypophosphites is an irrational prep>ation4 ,:ile its faults are few] & less gl>+ ?an ^? ( "s o!r propriet>ies1 ! circulation ( su* a te/imonial z ! "o j quot$ is suffici5t ( itself to ca/ suspicion on ! product4 ,,bor*]dt',s ,,malt ,,olive ,,) ,,hypophosphites1 ,,maltzyme ,,) ,,hypophosphites ,,& ,,malt9e ,,) ,,olive ,,oil ,,& ,,hypophosphites ,^! prep>ations are n[ describ$ 9 ! app5dix to ,new & ,non(ficial ,rem$ies4 ,bor*]dt's ,malt ,olive ) ,hypophosphites 7,bor*]dt ,malt ,extract ,company1 ,*icago7 is said to conta9 9 ea* #ajj c4c41 #j4fd gm4 ea* ( calcium & sodium hypophosphites1 ) malt extract1 olive oil & glyc]9e4 ,maltzyme ) ,hypophosphites 7,malt-,dia/ase ,company1 ,new ,york7 is said to conta91 9 ea* #ajj c4c41 #j4d gm4 ea* ( calcium1 sodium & potassium hypophosphites & #j4jje gm4 ea* ( iron & manganese hypophosphites1 ) maltzyme4 ,malt9e ) ,hypophosphites 7,malt9e ,company1 ,brooklyn1 ,n4 ,y47 is said to conta9 9 ea* #ajj c4c41 #j4fd gm4 ea* ( calcium & sodium hypophosphites & #j4db gm4 ( iron hypophosphite1 ) malt9e4 ,malt9e ) ,olive ,oil & ,hypophosphites 7,malt9e ,company1 ,brooklyn1 ,n4 ,y47 is said to conta91 9 ea* #ajj c4c41 #j4f gm4 ea* ( calcium & sodium hypophosphites1 ) malt9e & olive oil4 ,9 g5]al1 no !rapeutic claims are made = ^! mixtures s f> z ! hypophosphites are conc]n$4 ,! addition ( hypophosphites to su* mixtures is irrational &1 s9ce x t5ds to p]petuate ! hypophosphite fallacy1 detrim5tal to s\nd !rapeutics4 ,,! ,,c\ncil',s ,,action ,! ,c\ncil endors$ ! conclusions ( ! "w ( ,dr4 ,m>riott ref]r$ to above1 & not$3 7#a7 t ! !rapeutic use ( hypophosphites 7except possibly 9 "s cases z a conv5i5t means ( adm9i/]+ ! positive elem5t 9 ! salt1 z ammonium 9 ammonium hypophosphite or calcium 9 calcium hypophosphite7 is irrational2 7#b7 t ! m]its ( ea* hypophosphite salt submitt$ = consid]ation "u ! =ego+ exception mu/ be judg$ individually1 & 7#c7 t ,fell[s' ,syrup ( ,hypophosphites1 ,pet]s' ,syrupus ,roborans1 ,s*lott]beck's ,solution ,hypophosphites ( ,lime & ,soda1 ,rob9son's ,hypophosphites1 ! ,eupeptic ,hypophosphites ( ,nelson1 ,bak] ,co41 & ,mc,arthur's ,syrup ( ! ,hypophosphites are ineligible = inclusion 9 ,new & ,non(ficial ,rem$ies1 & t ,bor*]dt's ,malt ,olive ) ,hypophosphites1 ,maltzyme ) ,hypophosphites1 ,malt9e ) ,hypophosphites1 & ,malt9e ) ,olive ,oil & ,hypophosphites be delet$ f ! app5dix ( ,n4 ,n4 ,r4 ,( ^! prep>ations1 all are 9 conflict ) ,rule #aj2 ,fell[s' ,syrup1 ,s*lott]beck's ,solution1 ,rob9son's ,hypophosphites & ,nelson1 ,bak] ,co4's ,eupeptic ,hypophosphites are 9 conflict ) ,rule #f2 ! ,fell[s1 ,s*lott]beck1 & ,nelson1 ,bak] prep>ations are also 9 conflict ) ,rule #a4--7;,f ,! ,j\rnal ,a4 ,m4 ,a41 ,sept4 #b1 #aiaf47 ,,pulvoids ,,calcylates ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,pulvoids ,calcylates #e gra9s 0 submitt$ by ! ,drug ,products ,company1 ,inc41 ,new ,york1 "u ! foll[+ claims z to composition3 8,:5 +e/$ repres5ts ! foll[+ *emical =mulas3 ,,oh7 ,c,h ,,coo7 ,ca4#b;,h,o ,sr47,c,h,o7 #b;,h,o40 8,/rontium ,di-,salicylate #b-a_/b grs4 & our especially prep>$ ,salt ( ,calcium & ,acid ,salicylic adju/$ 9 su* nasc5t =m1 t ^! pulvoids ^u +e/ion w promptly =m ,calcium ,neutral ,di-,salicylate #b-a_/b gr40 8,a comb9ation ( ,calcium & ,/rontium ,di-,salicylate1 9 seem+ly true *emical union40 ,^! /atem5ts are r vague1 possibly because !y are an attempt to my/ify4 ,! product1 h[ev]1 may be assum$ to be a mixture 7n a *emical comb9ation7 ( calcium salicylate & /rontium salicylate4 ,! !rapeutic claims made = ! prep>ation are3 8,sup]ior to ord9>y salicylates4 ,c be tak5 cont9u\sly & indef9itely )\t ga/ric irritation1 insur+ maximum effici5cy40 8,reports %[ surpris+ly good results1 ev5 :]e ! sodium salt fails40 ,z !re is no evid5ce to %[ t /rontium salicylate1 calcium salicylate or a mixture ( ! two salts has any advantage ov] sodium salicylate1 ^! claims _c be accept$4 ,! "n & ! /atem5t ( composition are objectionable 9 t !y d n reveal ! id5tity ( ! drugs 9 8,calcylates0 & 9 sugge/+ t ?is prep>ation possesses radical advantages ov] salicylates 9 o!r =ms4 ,! ,drug ,products ,company 0 told t ! facts j m5tion$ r5d]$ 8,pulvoids ,calcylates0 ineligible = ,new & ,non(ficial ,rem$ies4 ,! company 9 its reply object$ to ! ,c\ncil's conclusions1 & 9 support ( its position submitt$ te/imonials f a numb] ( physicians4 ,! reply ( ! company embodi$ no facts or argum5ts :i* _h n be5 consid]$ by ! ,c\ncil's ref]ee1 & ! te/imonials f physicians conta9$ no evid5ce to %[ t ! comb9ation has any real advantage ov] sodium salicylate4 ,! ,c\ncil !re=e decl>$ 8,pulvoids ,calcylates0 ineligible = ,new & ,non(ficial ,rem$ies = ! foll[+ reasons3 ,unw>rant$ !rapeutic claims are made = ! mixture 7,rule #f72 ! "n does n describe ! composition 7,rule #h71 & ! mixture is an uness5tial modification ( an e/abli%$ rem$y 7sodium salicylate7 7,rule #aj74--7;,f ,! ,j\rnal ,a4 ,m4 ,a41 ,sept4 #i1 #aiaf47 ,,sulfuryl ,,monal ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,sulfuryl ,monal is said to be manufactur$ by ,monal ,frres1 manufactur+ *emi/s ( ,nancy1 ,france4 ,x is sold 9 ! ,unit$ ,/ates by ,george ,j4 ,wallau1 ,inc41 ,new ,york ,city4 ,accord+ to ! label3 ,conta9s3 ,sulfuryl 7comb9$ polysulphurets7 #j4ce c5tigr40 8,ea* ,pa/ille ,lib]ates3 ,nasc5t sulphurrett$ ,hydrog5 #b cub4 c5t40 ,! ,*emical ,laboratory ( ! ,am]ican ,m$ical ,association 0 reque/$ to *eck ! am\nt ( available hydrog5 sulphid4 ,an orig9al bottle ( ,sulfuryl ,monal 0 us$2 ?is conta9$ tablets hav+ ! ta/e ( licorice extract & an odor ( hydrog5 sulphid4 ,! tablets 7 f\nd to lib]ate ab\t #f c4c4 hydrog5 sulphid to ea* tablet4 ,among ! claims made = ! prep>ation are3 8,dissolv$ by ! saliva1 ,sulfuryl ,monal rea*es ! /oma* :]e1 "u ! influ5ce ( ! ga/ric juice1 x g5]ates nasc5t sulphurett$ hydrog54 ,pr(essor ,alb]t ,rob9's rem>kable rese>*es h prov5 t x is 9 ! nasc5t /ate t drugs produce ! greate/ effect ) ! smalle/ dose4444 ,be+ ?us elim9at$ by ! entire respiratory tract3 ! lungs1 bron*i & ! ?roat1 ! sulphurrett$ hydrog5 passes f ! int]ior to ! ext]ior1 t is to say1 goes "r ?r\gh ^! organs :i* are1 z a consequ5ce1 ?or\ghly cleans$1 antisepticiz$ & fre$ ( ! pa?og5ic micro-organisms4444 ,!n1 aga91 "p ( ! sulphurett$ hydrog51 lib]at$ 9 ! /oma*1 is elim9at$ by ! m\? & acts z an antiseptic & dis9fectant ( ! muc\s membranes ( ! ?roat & m\?4 ,h5ce ,sulfuryl ,monal is a p]fect protective ag5t aga9/ contagi\s diseases4444 ,num]\s cl9ical te/s h demon/rat$ its real efficacy 9 diseases ( ! ?roat & ( ! respiratory tract3 l>yngitis1 ph>yngitis1 ho>s5ess1 granulations1 tonsillitis1 colds1 bron*itis1 pulmon>y cat>rh1 a/hma1 emphysema1 grippe1 :oop+ c\gh1 simple & infecti\s pneumonia1 & 9 ! fir/ /age ( pulmon>y tub]culosis40 ,! sulphids are practically ignor$ 9 mod]n textbooks4 ,!re is a r ext5sive cl9ical lit]ature on ! subject1 p>ticul>ly 9 connection ) sulphur wat]s2 ?is1 h[ev]1 (f]s no good evid5ce = ! !rapeutic value ( sulphids4 ,probably ! tradition 9 _! favor is l>gely due to ! old popul> idea t a disagreeable ta/e or odor is a m>k ( a good rem$y4#ie #ie ,liquid ,sulphur--,sulphume1 ,j4 ,a4 ,m4 ,a41 ,dec4 #b1 #aiaa1 p4 #ahec4 ,:5 hydrog5 sulphid is introduc$ into ! body1 ! small am\nts t appe> 9 ! expir$ air are insuffici5t = quantitative demon/ration & x is highly improbable t ! am\nt ?us excret$ has any g]micidal action1 or t en\gh is excret$ 9 ! lungs to cause irritation & a reaction4 ,! claim t ,sulfuryl ,monal is 8a p]fect protective ag5t aga9/ contagi\s diseases0 is unw>rant$2 ! recomm5dation = its use 9 8simple & infecti\s pneumonia1 & 9 ! fir/ /age ( pulmon>y tub]culosis0 is dang]\s & vici\s4 ,! ,c\ncil decl>$ ,sulfuryl ,monal ineligible = ,new & ,non(ficial ,rem$ies & au?oriz$ publication ( ?is report4 ,editorial ,note44--,) "o exception1 ?is product does n appe> to be adv]tis$ 9 m$ical j\rnals4 ,we f9d1 h[ev]1 9 ! gall]y ( no/rums t grace ! adv]tis+ pages ( ! ,int]national ,j\rnal ( ,surg]y1 t ,sulfuryl ,monal has its place4 ,accord+ to an adv]tisem5t t has be5 runn+ "s mon?s 9 ?is publication1 8affections ( ! ?roat & respiratory organs respond promptly0 to ,sulfuryl ,monal ^: 8effects are rapid & c]ta90 ev5 9 8incipi5t tub]culosis40 ,?is prepo/]\s pron\ncem5t is no worse ?an _m o!rs appe>+ 9 ! same j\rnal1 b x is bad en\gh to indicate h[ uncritical mu/ be ! physicians :o support--by subscription or contribution--publications t are /ill debas+ sci5tific m$ic9e4--7,f ,! ,j\rnal ,a4 ,m ,a41 ,sept4 #af1 #aiaf47 ,,m>k ,,:ite ,,goit] ,,s]um ,,& ,,m>k ,,:ite ,,iod9iz$ ,,oil ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! 8,m>k ,:ite ,goit] ,s]um ,laboratories0 ( ,*icago ask$ ! ,c\ncil to consid] its products 8,m>k ,:ite ,goit] ,s]um0 & 8,m>k ,:ite ,iod9iz$ ,oil40 ,! 8s]um0 0 claim$ to be an 8antibody blood s]um f a goat ) ?yroidosis0 :ile ! 8,iod9iz$ ,oil0 0 said to conta9 8ab\t #d gra9s ( iod90 to 8ea* c4c40 ,! !rapeutic indications = ! treatm5t 7 giv5 z3 8,simple or ,exoph?almic ,goit]1 ,hyp]?yroidism-dosis1 ,?yrosis1 ,?yroidosis1 ,?yrotoxicosis1 ,dem5tia40 ,an ampule 7#b c4c47 ( ! 8s]um0 is to be inject$ into ! ?yroid to be foll[$ "o week lat] by an ampule 7#b c4c47 ( ! 8,iod9iz$ ,oil40 ,repetition ( ?is 8treatm5t0 once or twice a mon? is advis$4 ,! ,c\ncil ask$ = m specific in=mation z to ! composition ( ! rem$ies1 p>ticul>ly z to ! prep>ation & nature ( ! s]um2 x also ask$ = evid5ce ( ! !rapeutic value ( ! prep>ations4 ,9 reply1 ,m>k ,:ite wrote3 8,all t ,i c say reg>d+ ! s]um is t x is made f ! blood ( goats ) ?yroid affection1 & x has be5 f\nd t ! s]um f ^! goats has antibodies :i* control1 or has curative effect ^u ?yroid affections :5 inject$ into ?yroid gl&s ( ei!r humans or animals4 ,z to ! iod9is$ oil1 x is only an adjunct or side treatm5t :i* is n always us$ or indicat$1 & w only be furni%$ to ! physician = use 9 case 9 8 judgm5t 8 pati5t ne$s x4 ,we %all also advise ! use ( qu99 444 :5 indicat$44440 ,! ,c\ncil 0 ref]r$ = fur!r in=mation to a pap] by ,ra*el ,watk9s1 ,m4,d41 publi%$ 9 ! ,ill9ois ,m$ical ,j\rnal4 ,x is to be not$1 incid5tally1 t ! lett]heads us$ by ,:ite 9 8 correspond5ce bore 9 "o corn] ! notation 8,ra*el ,watk9s1 ,m4,d41 ,practice ,limit$ to ,goit] & ,o!r ,disord]s ( ! ,?yroid ,gl&s10 & 9 ! o!r1 8,m>k ,:ite1 ,goit] ,rese>*40 ,! in=mation reg>d+ ! composition ( ?is goit] treatm5t1 z furni%$ 9 ,dr4 ,watk9s' pap]1 0 to ?is effect3 8,! m$ical treatm5t consi/s ( ! adm9i/ration ( a blood s]um d]iv$ f a ?yrodiz$ goat4 ,=mula3 ,iod9e #j4af grams accord+ to a correction by ,m>k ,:ite1 ?is %\ld read #j4bf gm41 oil #j4be c4c41 s]um q4 s4 #a c4c40 ,?is description ( ! treatm5t diff]s f t furni%$ to ! ,c\ncil by ,m>k ,:ite 9 t "h ! iod9 & oil appe> to be comb9$ ) ! s]um4 ,dr4 ,watk9s' 8=mula0 implies t ! iod9 is a r\t9e m$ication1 ?us contradict+ ,:ite's /atem5t1 :i*1 9 turn1 is at v>iance ) ! /atem5ts made 9 submitt+ ! treatm5t4 ,illu/ration3 ,photographic reproductions 7greatly r$uc$7 ( "s ( ! lett]heads us$ by ! ,m>k ,:ite conc]n dur+ ! pa/ five ye>s4 ,! ,c\ncil does n accept any biologic product until its sale 9 int]/ate comm]ce has be5 au?oriz$ by ! secret>y ( ! treasury 9 accordance ) ! f$]al law regulat+ ! sale ( viruses1 s]ums1 tox9s & analog\s products4 ,! sale ( ! ,m>k ,:ite ,goit] ,s]um has n be5 s au?oriz$2 consequ5tly ev5 if ! prep>ation compli$ ) o!r rules ( ! ,c\ncil x c\ld n be accept$4 ,9 addition1 h[ev]1 ?is treatm5t conflicts ) o!r ,c\ncil rules4 ,! /atem5ts reg>d+ its composition are indef9ite & contradictory 7,rule #a72 ! evid5ce pres5t$ to support ! !rapeutic claims is insuffici5t 9 itself & does n appe> to h be5 *eck$ by any dis9t]e/$ au?ority 7,rule #f74 ,moreov]1 ! recogniz$ v>iation 9 ! morphology & pa?ology ( ! types ( goit] r5d] x impracticable to treat cases ( goit] by any r\t9e proc$ure4 ,! =ego+ report 0 submitt$ to ! ,m>k ,:ite ,goit] ,s]um ,laboratory4 ,9 reply1 a lett] sign$ 8,m>k ,:ite1 ,v4,m4,d410 0 receiv$1 :i* read1 9 "p3 8444 we hope at "s future "t to be able to give y m detail$ in=mation1 b z y possibly appreciate t we h exp]i5c$ = "s "t a dem& on ! "p ( _m physicians t we furni% to !m our !rapy1 :i* necessitates u furni%+ x be=e all ! detail$ "w has yet be5 accompli%$1 & ,i tru/ t y w be s k9d z to be> pati5tly ) u until we are bett] 9 a position to make a complete sci5tific application & report to y40 ,:ite wrote fur!r3 8,! s]um & iodiz$ oil may be mix$ = imm$iate use1 b c\ld n be put up only sep>ate = ! use ( ! pr(ession & ! !rapy furni%$ ,dr4 ,watk9s %e mix$ z us$40 ,?is /atem5t ?r[s no light on ! discrepancies 9 ! /atem5ts ) reg>d to ! place ( ! iod9iz$ oil 9 ! treatm5t1 namely3 7a7 ! orig9al /atem5t t ! oil 0 to be giv5 a week aft] ! s]um2 7b7 ,:ite's /atem5t 7quot$ e>li] 9 ?is report7 t ! oil 8is only an adjunct or side treatm5t0 & 8is n always us$ or indicat$02 7c7 ! /atem5t 9 ,dr4 ,watk9s' pap] t ! oil & ! s]um are giv5 9 comb9ation4 ,! ,c\ncil decl>$ ! ,m>k ,:ite ,goit] ,s]um & ,m>k ,:ite ,iod9iz$ ,oil ineligible = ,new & ,non(ficial ,rem$ies & au?oriz$ publication ( ?is report4 ,editorial ,note on ! ,m>k ,:ite 8,s]um0 ,z "s ( our read]s w rememb]1 on ,april #bf1 #aiac1 ,! ,j\rnal call$ att5tion to ! ,m>k ,:ite prep>ation :i* at t "t 0 be+ exploit$ f ,d5v]4 ,! ,propag&a ,dep>tm5t has 9 its files a numb] ( lett]s s5t out f ! ,m>k ,:ite conc]n at v>i\s times4 ,"o mail$ 9 ,may1 #aiaa1 on ! emboss$ /ation]y ( 8,! ,m>k ,:ite ,goit] ,in/itute10 ,ex*ange ,build+1 ,d5v]1 0 evid5tly a g5]al lett] s5t to physicians1 call+ _! att5tion to 8! mo/ important m$ical discov]y ( ! age40 8,dr4 ,m>k ,:ite1 a graduate ( ! ,univ]sity ( ,p5nsylvania10 said ! lett]1 _h discov]$ 8a simple & h>mless rem$y0 t w\ld cure goit]4 8,because ( ! desire to pres]ve ! secrecy ( ?is rem$y x is giv5 only at ! (fice "h40 ,x 0 !n sugge/$ t ! doctor might s5d ^? ( 8 pati5ts :o 7 suff]+ f ?yroidism to ! 8,m>k ,:ite ,goitre ,in/itute40 ,if he w\ld d s he w\ld be 8giv5 a commission ( #aj1 9 cases ( ! #ej fee ) ! additional #e = ea* #ej increase40 ,x clos$ ) "s casui/ic argum5ts1 presumably = ! purpose ( ov]com+ ! physician's scruples1 summ+ up ! matt] ) ! /atem5t3 8,no "r ?9k+ man w all[ a n>r[ & self-seek+ sy/em ( e?ics to /& betwe5 him & 8 duty to ! sick & suff]+40 ,ab\t #aiab ! "n ( ! conc]n seems to h be5 *ang$1 = we h 9 our files a lett] address$ to a layman on ! /ation]y ( ! 8,m>k ,:ite ,goitre ,treatm5t ,company40 ,accord+ to ?is lett]head ! product ?is conc]n _h = sale 0 8,goitre9e0 discov]$ by ,m>k ,:ite1 8,presid5t & ,g5]al ,manag]40 ,mr4 ,:ite's lett] to ! suff]] f goit] assur$ him t if he w\ld take 8,goitre9e0 he might 8be practically sure ( an imm$iate & p]man5t cure40 8,goitre9e10 accord+ to ,:ite1 8has absolutely & p]man5tly cur$ #ij p] c5t40 ( all cases ( goit] 9 :i* x has be5 us$--8& ! o!r t5 %[$ rem>kable improvem5t40 ,x 0 efficaci\s = all =ms ( goit] & 8_c possibly h>m40 ,! p]son :o receiv$ ?is assurance might h _h 8 confid5ce 9 x %ak5 _h he se5 a copy ( ! ,d5v] ,news = ,may #bc1 #aiaa1 9 :i* 0 report$ a case ( collapse & dea? 9 a woman foll[+ an injection giv5 9 ,:ite's (fice4 ,! pap] /at$ t ! dea? c]tificate 0 sign$ by "o ,w4 ,a4 ,gray & gave 8fatty deg5]ation ( ! he>t & goit]0 z ! cause ( dea?4 ,gray1 x seems1 0 ! lic5s$ physician employ$ by ,m>k ,:ite to adm9i/] 8,goitre9e0--if t is :at ,:ite happ5$ to be call+ 8 product at t "t4 ,= "h x may be /at$1 p>5!tically1 t ,m>k ,:ite is n a physician2 he is a vet]9>ian4 ,9 ,febru>y1 #aiac1 ,m>k ,:ite s5t a circul> lett] to a numb] ( m$ical publications ) ! reque/ t x be pr9t$ 9 full 9 ! next issue1 8to cov] "o full page ( space40 ,! lett] ,:ite want$ pr9t$ 0 address$ to doctors (f]+ to 8ent] into a cop>tn]%ip agreem5t0 ) su* physicians :o w\ld be will+ to treat 8pati5ts ) goit] affections on a #ej p] c5t4 commission basis40 8,y w\ld be expect$ to make a ca% *>ge to ! pati5t = ! treatm5t1 remitt+ on ! same day our #ej p] c5t4 to u1 :5 ord]+ ! treatm5t1 giv+ ! treatm5t 9 no cases = less ?an #ej4jj40 ,ab\t ! same "t t ,m>k ,:ite made ?is 8fifty-fifty0 (f]1 he s5t 9 an adv]tisem5t to be publi%$ 9 ! classifi$ column ( ,! ,j\rnal4 ,at t "t he 0 told 8 adv]tisem5t 0 n acceptable2 we n[ repr9t x1 h[ev]1 free ( *>ge4 ,"h x is3 8,,want$--,,"o ,,or ,,m ,,physicians 9 ea* vic9ity to adm9i/] & repres5t our new m$ical treatm5t = ,,goit]4 ,good m>g9 ( pr(it4 ,write = copy ( contract4 ,! ,m>k ,:ite ,goitre ,treatm5t ,co41 ,d5v]1 ,colo40 ,9 #aiad1 ,:ite mov$ to ,*icago4 ,at lea/ ! c>d :i* we reproduce s indicates4 ,at t "t1 z w be se51 8,dr4 ,m>k ,:ite0 0 8p]sonally associat$0 ) ,pet] ,s4 ,cl>k1 ,m4,d4 ,accord+ to ! same c>d ,dr4 ,f4 ,d4 ,paul ( ,rock ,isl&1 ,ill41 seems to h be5 8 8associate0 = t p>ticul> locality4 ,9 ?is connection1 x is wor? not+ t a ,rock ,isl& pap]1 9 "o ( its issues dur+ ,july1 #aiac1 devot$ a good deal ( space to 8,dr4 ,m>k ,:ite0 :o 0 at t "t 9 ,rock ,isl& 8direct+ ,dr4 ,frank ,d4 ,paul 9 ! adm9i/]+ ( ! treatm5t40 ,!re 0 no?+ to indicate t ?is notice 0 an adv]tisem5t or t ! editorial appe>+ 9 ! same issue puff+ ,:ite's 8important cure10 0 paid =4 ,illu/ration3 ,:5 exploit$ f ,d5v] ! ,m>k ,:ite 8goit] cure0 0 adv]tis$ 9 ! daily pap]s4 ,"h is a photographic reproduction 7r$uc$7 ( an adv]tisem5t t appe>$ 9 ! ,d5v] ,po/1 ,sept4 #a1 #aiab4 ,dr4 ,w4 ,a4 ,gray1 :o has already be5 m5tion$ z ,:ite's associate 9 ,d5v]1 seems to h be5 do+ bus9ess 9 ,ill9ois "s "t 9 #aiac & a ,pr9ceton 7,ill47 pap] _h "s uncomplim5t>y ?+s to say ab\t him4 ,f9ally 9 ,july1 #aiac1 ?is item appe>$ 9 a ,pr9ceton pap]4 8,dr4 ,w4 ,a4 ,gray1 ! goit] speciali/ :o op]at$ la/ w9t] at ,pr9ceton & ,walnut until he became embroil$ ) ,dr4 ,m>k ,:ite1 a ,d5v] vet]9>y & orig9ator ( ! cure1 ov] a division ( ! spoils1 has op5$ a goit] in/itute 9 ,*icago "u 8 own "n4 ,adv]tisem5ts ( ! ,dr4 ,gray ,goit] ,in/itute appe>$ ,sunday morn+ 9 ! ,*icago ,exam9] & o!r morn+ pap]s4 ,dr4 ,gray & ,m>k ,:ite broke (f _! relations aft] _! disagreem5t at ,walnut1 & ,dr4 ,gray slightly *ang$ ! +r$i5ts ( ! goit] cure & />t$ (f on 8 own hook40 ,"o ( ,gray's adv]tisem5ts 9 ,*icago newspap]s made ! claim t 8,dr4 ,gray's ,new ,m$ical ,treatm5t removes ! cause ( goit] 9 sev5 days40 ,illu/ration3 ,photographic reproduction 7r$uc$7 ( ! 8pr(essional0 c>d us$ by 8,dr4 ,m>k ,:ite0 aft] he came to ,*icago4 ,! ,tulsa 7,okla47 associate ( 8,dr40 ,:ite seems to h be5 ,dr4 ,j4 ,h4 ,morgan & ! ,tulsa pap]s ( ,june1 #aiad1 tell ( 8,dr40 ,:ite's visit to t city 8= ! purpose ( in/ruct+ ,dr4 ,j4 ,h4 ,morgan 9 ! te*nique ( 8 new m$ical treatm5t = n]v\s disord]s & goit]40 ,"s mon?s lat]--9 ,decemb]1 #aiae--! foll[+ little item appe>$ 9 a ,tulsa pap]3 8,dr4 ,m>k ,:ite 0 f\nd guilty 9 ! c\nty c\rt ye/]day ( practic+ m$ic9e )\t a lic5se & 0 f9$ #ej4 ,doctor ,:ite is a goit] speciali/40 ,9 ,septemb]1 #aiae1 ,mr4 ,?omas ,s4 ,hogan1 ! effici5t c\nsel = ! ,ill9ois ,/ate ,bo>d ( ,heal?1 in/itut$ action aga9/ ,m>k ,:ite = practic+ m$ic9e )\t a lic5se4 ,! case 0 tri$ ,oct4 #ae1 #aiae1 & ! jury1 aft] be+ out f\r h\rs1 return$ a v]dict ( 8n guilty40 ,attorney ,hogan attributes ! failure to obta9 a conviction to ! te/imony ( ,dr4 ,ra*el ,watk9s1 :o said %e _h a p>tn]%ip arrangem5t ) ,:ite 9 c>ry+ on ! m$ical bus9ess4 ,x 0 ab\t ?is "t t ,m>k ,:ite seems to h issu$ "s new lett]heads4 ,^! bore 9 _! upp] left h& corn] ! device 8,ra*el ,watk9s1 ,m4 ,d41 ,practice ,limit$ to ,goit] & ,o!r ,disord]s ( ! ,?yroid ,gl&s10 :ile ! upp] "r h& corn] read 8,m>k ,:ite1 ,goit] ,rese>*40 ,on ,dec4 #i1 #aiae1 ,ra*el ,watk9s1 ,m4 ,d41 ( ,*icago1 read a pap] entitl$ 8,a ,s]um ,treatm5t = ,physiologically ,defective ,?yroids1 ,) ,cl9ical ,reports0 be=e ! ,/ock ,y>ds ,bran* ( ! ,*icago ,m$ical ,society4 ,! 8s]um treatm5t0 discuss$ 0 ,m>k ,:ite's 8,goitre9e0 :i*1 9 ! c\rse ( its *eck]$ c>e]1 _h lo/ its orig9al "n by ! wayside4 ,?is pap] appe>$ 9 ! ,decemb]1 #aiae1 issue ( ! ,ill9ois ,m$ical ,j\rnal4 ,probably embold5$ by ! ease ) :i* a compon5t "p ( ! ,am]ican ,m$ical ,association 8fell =0 a pap] exploit+ a 8goit] cure10 ,dr4 ,watk9s reque/$ t %e be p]mitt$ to read a pap] on ! same subject be=e ! ,section on ,ph>macology & ,!rapeutics at ! ,detroit meet+ ( ! ,am]ican ,m$ical ,association la/ ,june4 ,! reque/ 0 refus$4 ,dr4 ,watk9s is app>5tly no long] connect$ ) ,:ite & 9 fact has prote/$ aga9/ ! use ( h] "n by ,:ite 9 connection ) 8 8goit] cure40 ,aft] ! above 0 9 type & ready = ! pages ( ,! ,j\rnal1 att5tion 0 call$ to ! ,(ficial ,bullet9 ( ! ,*icago ,m$ical ,society ( ,sept4 #af1 #aiaf4 ,?is ,bullet9 conta9$ a full page adv]tisem5t ( ! ,m>k ,:ite 8goit] cure40 ,! adv]tis] ref]r$ to ! prep>ation z hav+ be5 8ann\nc$ to ! ,*icago ,m$ical ,society0 & decl>$ x to be 8an e?ical !rapeutic ag5t40 ,m>k ,:ite 0 describ$ z 8a m$ical rese>* /ud5t0 b no h9t 0 giv5 t he is a vet]9>ian4 ,aft] aga9 emphasiz+ t 8?is !rapy is e?ically prov50 physicians 7 invit$ to 8visit our goats :5 conv5i5t0 & ! adv]tisem5t clos$ ) ! mode/ claim t 8?is ?yroid !rapy has equal curative !rapeutic value 9 ^! cases z qu99 9 mal>ia40 ,& ?is sort ( pseudo-sci5tific claptrap is pres5t$ to a presumably le>n$ pr(ession ?r\gh its own (ficial ,bullet9--b :at's ! use ( comm5t+6--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,sept4 #bc1 #aiaf47 ,,kora-,,konia ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,kora-,konia is a 8du/+ p[d]0 :i* at pres5t is adv]tis$ to ! m$ical pr(ession ?r\gh m$ical j\rnals1 circul>s1 po/ c>ds & sample packages4 ,x is put out by ! 8,h\se ( ,m5n510 :i* sells v>i\s toilet prep>ations su* z talcum p[d]1 %av+ soap1 etc4 ,on ! trade package is ! /atem5t3 8,indicat$ 9 ! treatm5t ( ,acne1 ,d]matitis1 ,eczema ,int]trigo2 9 ob/9ate cases ( *af+1 prickly heat1 nettle ra%1 *ick5 pox1 measles1 sc>lat9a & irritations ( ! sk92 z a soo?+ absorb5t & antiseptic du/+ p[d] & z an umbilical dress+40 ,:ile a circul> ass]ts t3 8,kora-konia is indicat$ 9 ! treatm5t ( acne1 d]matitis1 eczema & eczemat\s conditions ( ! utmo/ sev]ity1444 eruptive fev]s14440 ,:at purports to be a physician's te/imonial reads3 8,i us$ ,kora-,konia 9 a new born case ( inh]it$ syphilis & ! eruption soon cle>$ up40 ,g]micidal p[]s are claim$ = ,kora ,konia 9 a m$ical j\rnal adv]tisem5t4 ,9 view ( ! v>i\s claims made & ! fact t x is adv]tis$ to ! m$ical pr(ession1 ! ,*emical ,laboratory ( ! ,am]ican ,m$ical ,association 0 ask$ to analyze ,kora-,konia4 ,?is 0 done & ! *emi/s report$ z foll[s3 ,,laboratory ,,report ,kora-,konia is a :ite p[d]1 slightly greasy to ! t\*4 ,qualitative te/s %[$ ! pres5ce ( boric acid1 z9c1 magnesium1 a solid fatty acid & mat]ial insoluble 9 hydro*loric acid conta9+ magnesium & alum9um4 ,/>* 0 n f\nd4 ,quantitative det]m9ations gave ! foll[+ results3 ,acid-insoluble mat]ial 7talc7 #dh4c p] c5t4 ,magnesium 7,mg7 soluble 9 dilute acid #a4b p] c5t4 ,z9c 7,zn7 #d4e p] c5t4 ,/e>ic acid 7impure7 #ci4b p] c5t4 ,boric acid #c4j p] c5t4 ,c>bon dioxide 7,,co7 #a4e p] c5t4 ,f ?is analysis x is conclud$ t ,kora-,konia has ess5tially ! foll[+ composition3 ,z9c /e>ate ,u4 ,s4 ,p4 #dd p] c5t4 ,talc #dh p] c5t4 ,magnesium c>bonate ,u4 ,s4 ,p4 #e4j p] c5t4 ,boric acid #c4j p] c5t4 ,ess5tially ?is du/+ p[d] consi/s ( ! well-kn[n sub/ances talc & z9c /e>ate 9 ab\t equal proportions to :i* small quantities ( magnesium c>bonate & boric acid h be5 add$4 ,inasmu* z ! claim is made1 by inf]5ce at lea/1 t ,kora-,konia repres5ts orig9al inve/igation c>ri$ out 8) ! coop]ation ( ! m$ical pr(ession0 x %\ld be /at$ t ! prep>ation ( comm]cial z9c /e>ate 0 describ$ & recomm5d$ z a du/+ & toilet p[d] ne>ly tw5ty-five ye>s ago4#if #if ,proc4 ,am4 ,ph>m4 ,a4 #dj3dhh1 #ahib4 ,!re is no?+ new or orig9al 9 any "o ( ^! sub/ances or 9 ! comb9ation4 ,! extravagant & unw>rant$ claims made = ?is simple du/+ p[d] are und\bt$ly lead+ ! public z well z "s ?\ghtless physicians1 to place undes]v$ confid5ce 9 x4 ,9 view ( ! small am\nt ( boric acid pres5t 9 ! p[d]1 its antiseptic p[]s mu/ be slight & its g]micidal p[]s almo/ nil4 ,! ,c\ncil decl>$ ,kora-,konia ineligible = ,new & ,non(ficial ,rem$ies & au?oriz$ publication ( ?is report4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,sept4 #cj1 #aiaf47 ,,! ,,!rapeutic ,,value ,,( ,,! ,,glyc]ophosphates ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has adopt$ ! foll[+ report & au?oriz$ its publication4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,glyc]ophosphates are ! salts ( glyc]ophosphoric acid1 ,h,c,h7,,oh7,,po4 ,?is acid is produc$ by ! int]action ( glyc]9 & phosphoric acid4 ,9 g5]al1 only sodium glyc]ophosphate1 ,na,c,h7,,oh7,,po #e-a_/b;,h,o1 & calcium glyc]ophosphate1 ,ca,c,h7,,oh7,,po ,h,o1 are us$ 9 m$ic9e1 ?\gh ! glyc]ophosphates ( li?ium1 potassium1 manganese1 magnesium1 iron1 qu99 & /ry*n9 are claim$ z con/itu5ts ( propriet>y prep>ations4 ,at a "t :5 c]ta9 disord]s 7 assum$ to be due to a defici5cy ( phosphorus 9 ! n]ve /ructure 9 ! body1 glyc]ophosphates 7 introduc$ z 8n]ve foods0 & 8tonics0 on ! !ory t !y w\ld be assimilat$ m readily ?an hypophosphites or ord9>y phosphates4 ,:at l$ to ?is assumption 0 ! fact t ! leci?9s1 :i* =m a "p ( ! n]ve /ructure1 7 kn[n to conta9 ! glyc]ophosphate radical 9 ! molecule4 ,! belief t inorganic phosphates _c supply ! body's ne$ ( phosphorus is impli$ or express$ 9 mo/ ( ! 8lit]ature0 devot$ to propriet>y phosphorus prep>ations4 ,?us1 ,s*]+ & ,glatz quote ,g4 ,meillire z say+ t 8! organism is incapable ( assimilat+ inorganic =ms ( phosphorus40 ,aga91 :5 exploit]s ( glyc]ophosphates admit t ! body c syn!size its phosphorus comp\nds f inorganic phosphates1 !y attempt to c\nt]balance ! admission by cont5d+ t ! use ( organic comp\nds 8sp>es0 ! sy/em ! necessity ( mak+ su* syn!sis4 ,?is assumption re/s on ! !ory t ! organic phosphorus comp\nds are absorb$ & /or$ z su*4 ,?is !ory is contradict$ by evid5ce :i* has be5 pres5t$#ig t ! organic phosphorus comp\nds are split up into inorganic phosphates be=e absorption4 #ig ,mc,collum & ,h>t1 ,gross] & ,husl]1 ,plimm]1 & ,bayliss & ,plimm]1 quot$ by ,m>%all 7,note #b74 ,! ,c\ncil reque/$ ,e4 ,k4 ,m>%all1 ,jr41 to review ! evid5ce = & aga9/ ! !rapeutic value ( organic phosphorus comp\nds4 ,m>%all's /udy#ih br+s out ! foll[+ po9ts3 #ih ,m>%all1 ,e4 ,k43 ,! ,!rapeutic ,value ( ,organic ,phosphorus ,comp\nds1 ,j4 ,a4 ,m4 ,a41 ,feb4 #ac1 #aiae1 p4 #egc4 #a4 ,9 v>i\s tissues ( ! animal body1 enzymes h be5 f\nd :i* hydrolyze complex organic phosphorus comp\nds s z to lib]ate ! phosphorus 9 ! =m ( inorganic phosphates4 #b4 ,metabolism /udies ( ! phosphorus balance ) diets conta9+ inorganic phosphorus comp\nds1 z comp>$ ) diets conta9+ organically b\nd phosphorus1 are some:at conflict+ 9 _! results4 ,! balance ( evid5ce1 h[ev]1 is 9 favor ( ! view t !re is no diff]5ce betwe5 organically comb9$ phosphorus & inorganic salts ) respect to ! phosphorus balance4 #c4 ,exp]im5ts indicate t ! organism ?rives on & supplies its phosphorus ne$s q z well f inorganic phosphorus comp\nds z f organically b\nd phosphorus4 ,m>%all concludes3 8,we see t ! evid5ce is v conv9c+ ( ! view t ! animal organism c syn!size its complex organic phosphorus con/itu5ts f inorganic phosphates1 & t organic phosphorus is ( no m value z a food ?an inorganic40 ,9 view ( ?is report1 ! ,c\ncil deem$ x advisable to take up ! consid]ation ( c]ta9 glyc]ophosphate prep>ations on ! m>ket4 ,z ! !rapeutic claims are all simil>1 x is n necess>y to quote !m ext5sively4 ,,tonols 7,,s*]+',s ,,glyc]ophosphates7 ,tonols 7,s*]+ & ,glatz1 ,new ,york7 comprise iron1 lime1 li?ium1 magnesium1 manganese1 potassium1 qu991 sodium & /ry*n9 8,tonols0 or glyc]ophosphates2 also ,duotonol ,tablets1 said to conta9 equal p>ts ( calcium & sodium glyc]ophosphates2 ,triotonol ,tablets1 ea* said to conta9 8,sodium ,tonol #b-a_/b gra9s1 ,lime-,tonol #b-a_/b gra9s1 ,/ry*n9e-,tonol #a_/fj gra902 ,qu>tonol ,tablets1 said to conta9 8,sodium & ,lime-,tonols1 ea* #b-a_/d gra9s1 ,qu99e ,tonol #a_/b gra91 ,/ry*n9e-,tonol #a_/bjj gra902 ,sextonol ,tablets1 said to conta9 8,sodium & ,lime-,tonols1 ea* #b gra9s1 ,iron-,tonol1 #a_/b gra91 ,manganese & ,qu99e-,tonols1 ea* #a_/d gra91 ,/ry*n9e-,tonol1 #a_/bjj gra940 ,! "n 8,tonols0 is objectionable 9 t x is n only nondescriptive ( ! composition1 b also !rapeutically 7& falsely7 sugge/ive4 ,! composition ( ! m elaborate ,tonols is p>ticul>ly unsci5tific2 !re is no ju/ification = comb9+ qu991 /ry*n91 iron1 manganese1 etc41 9 "o =mula4 ,,phosphorc9 ,,comp\nd ,phosphorc9 ,comp\nd1 call$ 8,! ,elem5t>y ,phosphorus indicat$ 9 all =ms ( ,n]v\s ,diseases0 & ! 8,p]fect ,=mula10 is said to be manufactur$ by ! ,organic ,products ,company1 ,wetzl> an d] ,lahn1 ,g]many1 & ,gre5wi*1 ,conn4 ,x is sold 9 ! ,unit$ ,/ates by ,eim] & ,am5d1 ,new ,york1 accord+ to :om3 8,ea* two fluidra*ms conta93 8,acidulat$ ,bone ,phosphor ,o4 ,p4 ,co4 #b gra9s 8,calcium ,glyc]9ophosphate1 ,m]ck ,co4 #a-a_/b gra9s 8,magnesium ,glyc]9ophosphate1 ,m]ck ,co4 #a-a_/b gra9s 8,sodium ,glyc]9ophosphate1 ,m]ck ,co4 #b-a_/b gra9s 8,lactat$ ,peps9 #b gra9s 8,ignatia ,extract #a_/bj gra9 8,c4 ,p4 ,glyc]9 7,special ,process7 ,o4 ,p4 ,co4 #ej p] c5t4 8,acidulat$ bone phosphor0 presumably is acid phosphate ( calcium4 ,?is =mula is an unsci5tific %otgun comb9ation4 ,,rob9ol ,rob9ol1 manufactur$ by ,john ,wye? & ,bro!r1 ,philadelphia1 is call$ a 8,univ]sal ,tonic40 ,x is said to be3 8,a prep>ation ( ! glyc]ophosphates ( li?ium1 calcium1 sodium1 iron1 manganese1 qu99e1 ) #a-af gr4 /ry*n9e glyc]ophosphate 9 ea* fluid\nce40 ,?is is a semisecret prep>ation1 s9ce ! quantities ( mo/ ( ! +r$i5ts are n giv5 & ! vehicle is n nam$4 ,?is complex comb9ation1 too1 is unw>rant$4 ,,phosphoglyc]ate ,,( ,,lime 7,,*apoteaut7 ,?is is said to be prep>$ by ! ,laboratories de ,ph>macologie ,gnrale1 ,dr4 ,ph4 ,*apelle1 ,p>is & ,new ,york4 ,x is sold 9 ?is c\ntry by ,e4 ,f\g]a & ,co41 ,inc41 ,new ,york4 ,x is (f]$ 9 sev]al =ms1 especially 9 t ( w9e1 :i* is call$ ! 8,m$ic9al ,w9e & ,tonic ,p> ,excell5ce40 ,! alcohol is no d\bt ! con/itu5t to :i* ?is prep>ation is indebt$ = su* popul>ity z x has atta9$1 = x is mu* m freely adv]tis$ ?an ! syrup1 capsules or granulat$ =m4 ,! usual claims are made ) reg>d to ! efficacy ( calcium glyc]ophosphate 8dur+ convalesc5ce1 9 cases ( enfeebl$ vitality1 & n]v\s affections associat$ ) an excessive elim9ation ( phosphates40 ,,elixir ,,glyc]ophosphates1 ,,nux ,,vomica ,,& ,,damiana ,?is is manufactur$ by ,%>p & ,dohme1 ,baltimore4 ,! manufactur]s' /atem5t ( composition is3 8,ea* fluid\nce repres5ts ,nux ,vomica #h gra9s1 ,damiana #fd gra9s1 comb9$ ) ,glyc]ophosphates ( ,calcium & ,sodium40 8,alcohol #bj p] c5t40 ,%>p & ,dohme call ?is mixture a 8,recon/ructive ,n]ve ,/imulant1 ,aphrodisiac10 & claim t3 8,phosphorus 9 elem5tal =m has long be5 prescrib$ "u ! title ( ,elixir ,phosphorus1 ,nux ,vomica & ,damiana1 b due to ! rapidity ( *emical *ange occurr+ 9 prep>ations conta9+ ?is =m ( ,phosphorus1 mu* ( ! ,physiologic action is lo/4 ,! ,glyc]ophosphates pres5t ,phosphorus 9 its mo/ available =m--! =m 9 :i* x exi/s 9 ! bra9 & n]v\s sy/em4 ,!y p[]fully /imulate ! functions ( nutrition & are rapidly assimilat$ by ! sy/em4 8,nux ,vomica is a g5]al ,n]ve ,tonic4 ,damiana ex]ts a /imulant effect ^u ! sexual appetite & function40 ,! claim t ! glyc]ophosphates may be sub/itut$ = elem5t>y phosphorus is1 at lea/1 novel4 ,! elixir is an unsci5tific semisecret comb9ation4 ,,recomm5dations ,all ( ! prep>ations m5tion$ violate ,rule #f 7unw>rant$ !rapeutic claims74 ,9 addition1 ,rob9ol & ,elixir ,glyc]ophosphates1 ,nux ,vomica & ,damiana violate ,rule #a 7secrecy ( composition7 9 t n all ! quantities ( ! +r$i5ts are decl>$2 ,tonols1 ,phosphorc9 ,comp\nd & ,rob9ol violate ,rule #h 7objectionable names74 ,x is recomm5d$ t ! ,c\ncil endorse ,m>%all's f9d+s#ih & decl>e t ,tonols 7,s*]+ & ,glatz71 ,phosphorc9 ,comp\nd 7,eim] & ,am5d71 ,rob9ol 7,john ,wye? & ,bro!r71 ,phosphoglyc]ate ( ,lime ,*apoteaut 7,e4 ,f\g]a & ,co471 & ,elixir ,glyc]ophosphates1 ,nux ,vomica & ,damiana 7,%>p & ,dohme7 are ineligible = ,new & ,non(ficial ,rem$ies4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,sept4 #cj1 #aiaf47 ,,hydras ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,hydras1 sold by ,john ,wye? & ,bro!r1 ,philadelphia1 is "o ( ! _m propriet>y1 s-call$ 8ut]9e tonics40 ,x is said to conta9 8,cramp ,b>k1 ,helonias ,root1 ,hydra/is1 ,scutell>ia1 ,dogwood & ,aromatics10 b z ! am\nts ( ! sev]al +r$i5ts are n giv5 ! /atem5t reg>d+ its composition is valueless4 ,! label decl>es ! pres5ce ( #bd p] c5t4 alcohol4 ,! "n 8,hydras10 tak5 9 connection ) ! /atem5t ( composition1 w\ld sugge/ t hydra/is 7gold5-seal7 is an important con/itu5t4 ,! report ( ! ,*emical ,laboratory ( ! ,am]ican ,m$ical ,association1 h[ev]1 indicates t hydra/is is pres5t 9 unimportant am\nts3 8,! hydra/9 cont5t ( ,hydras 0 det]m9$ by extraction ) immiscible solv5ts 7,ph>m4 ,review1 ,may1 #aijh1 p4 #acb74 ,tw5ty-five c4c4 0 f\nd to yield an alkaloid residue ( #j4jafj gm4 ,! prep>ation conta9s1 !re=e1 n m ?an #j4jfd gm4 #8hydra/9' p] #ajj c4c4 ,inasmu* z hydra/is is requir$ to conta9 ab\t #b4e p] c5t4 #8hydra/91' hydras conta9s an equival5t ( n m ?an #b4ef gm4 hydra/is 7gold5 seal7 9 #ajj c4c4 & ! /at$ dose ( ,hydras--"o dess]tspoonful 7#h c4c47--repres5ts n m ?an #j4b gm4 or #a_/aj ( ! ,u4 ,s4 ,p4 av]age dose ( hydra/is40 ,! label ( a rec5tly pur*as$ bottle ( ,hydras be>s ! foll[+ recomm5dations = its use3 8,indicat$ 9 treatm5t ( ,dysm5orrhea1 ,m5orrhagia ,anti-,abortive1 ) anodyne & tonic prop]ties40 8,= dysm5orrhea1 suppress$ m5ses1 etc41 a dess]tspoonful ?ree times daily1 be=e or aft] meals40 8,to relieve pa9 due to ut]9e disord]s1 a dess]tspoonful e ?ree h\rs1 or increas$ to a tablespoonful1 at ! discretion ( ! att5d+ physician40 ,a circul> wrapp$ ar\nd ! bottle decl>es t ,hydras is3 8,a valuable prep>ation to ! physician 9 ! treatm5t ( dysm5orrhea1 colic1 cramps1 spasm1 palpitation incid5t to pregnancy1 & ! v>i\s pa9s result+ f diseases ( ! female sexual organs40 ,x is fur!r claim$ t3 8,9 ! dysm5orrhea ( "y girls due to "s me*anical difficulty1 z anteflexion or ( a conge/ive "*1 ( suppress$ m5ses f exposure to cold & o!r causes ( a simil> "*1 ,hydras w prove effici5t & c be adm9i/]$ freely )\t dang]40 ,! value ( hydra/is 9 ! treatm5t ( ! diseases & conditions m5tion$ is problematical at be/1 & ! small am\nt pres5t 9 ,hydras is :olly useless4 ,z = ! o!r con/itu5ts1 cramp b>k 7,viburnum opulus71 helonias 7false unicorn--,*amlirium luteum or ,helonias dioica7 & scutell>ia 7skullcap--,scutell>ia lat]iflora7 are drugs :i* are practically ignor$ by mo/ writ]s on mat]ia m$ica & !rapeutics4#ii ,dogwood 7,cornus florida7 is a mildly a/r+5t aromatic bitt] = ! use ( :i* !re is no sci5tific evid5ce4#ajj #ii ,see reports ( ! ,c\ncil1 ,j4 ,a4 ,m4 ,a41 ,jan4 #i1 #aiae1 p4 #afe2 ,jan4 #bc1 #aiae1 p4 #cei2 ,nov4 #bg1 #aiai1 p4 #ahcf2 ,m>* #bg1 #aiae1 p4 #ajic4 #ajj ,see ,reports ,c\ncil ,ph>m4 & ,*em41 #aiab1 p4 #cf4 ,to sum up3 ,( ! five +r$i5ts ( ,hydras 7aside f alcohol & aromatics71 "o 7hydra/is71 :i* app>5tly gives ! prep>ation its "n1 is pres5t 9 unimportant am\nts2 ?ree 7cramp b>k1 helonias & scutell>ia7 are !rapeutically unimportant2 ! fif? 7dogwood7 has nev] be5 %[n to h any specific action on ! ut]us4 ,! pot5t con/itu5t1 !re=e1 appe>s to be ! alcohol4 ,b1 ev5 if e "o ( ! sev]al drugs said to be conta9$ 9 ,hydras 7 possess$ ( di/9ct !rapeutic prop]ties1 & if ea* 7 pres5t 9 kn[n & !rapeutically active am\nts1 /ill ! comb9ation 9 fix$ proportion w\ld be irrational4 ,no "o c\ld =esee ! jo9t effect ( ! five drugs 9 ! sev]al conditions = :i* ! mixture is adv]tis$4 ,hydras is evid5tly meant to appeal to ! ?\ghtless & to be us$ at r&om2 witness ! sugge/ion made 9 ! adv]tis+ t 8,ow+ to its palatability1 x is acceptable to pati5ts ) impair$ dige/ion1 & w s]ve z a /oma*ic tonic1 promot+ appetite & dige/ion40 ,a useless alcoholic no/rum 8adm9i/]$ freely0 to wom5 & girls is z dang]\s z ! recomm5dation = su* adm9i/ration is repreh5sible4 ,?is prep>ation is semisecret4 ,! recomm5dations = its use 9 specifi$ diseases :i* appe> on ! label & 9 ! adv]tis+ accompany+ ! bottle are sure to lead to its ill-advis$ use by ! public4 ,! claims made = its curative prop]ties are exagg]at$ & unw>rant$4 ,! "n1 9 view ( ! small cont5t ( hydra/is1 is mislead+4 ,f9ally1 ! comb9ation ( five drugs1 ev5 if individually !y 7 ( !rapeutic value1 is irrational4 ,hydras1 consequ5tly1 is inadmissible to ,new & ,non(ficial ,rem$ies = conflict ) ,rules #a1 #d1 #f1 #h & #aj1 & publication ( ?is report is au?oriz$4 ,editorial ,comm5t4--,products l 8,hydras0 are ! bane ( sci5tific m$ic9e4 ,! physician :o prescribes !m c\ld ) j z mu* reason prescribe any ( ! v>i\s alcoholic 8pat5t m$ic9es0 ( ! 8wom5's tonic0 type4 ,9 fact1 8 pati5ts w\ld be runn+ less risk ( contract+ ! alcohol habit if he prescrib$ ! 8pat5t m$ic9es10 z ^! no/rums usually h less alcohol ?an is conta9$ 9 _! 8e?ical0 prototypes--& alcohol is ! only really important drug 9 practically all ( !m4 ,:atev] "o may ?9k ( reputable ph>maceutical h\ses :o put out products ( ! 8,hydras0 type1 ! fault really lies ) ! pr(ession :i* tol]ates su* !rapeutic mon/rosities4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,oct4 #g1 #aiaf47 ,,brom9-,,iod9 ,,comp\nd ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry 8,brom9-,iod9 ,comp\nd10 accord+ to ! ,brom9-,iod9 ,*emical ,company1 ,san ,diego1 ,calif41 has ! foll[+ 8=mula03 ,iod9 ,gr4 #a ,brom9 ,gr4 #a_/d ,phosphorus ,gr4 #a_/ajj ,?ymol ,gr4 #b_/c ,m5?ol ,gr4 #b_/c ,/]iliz$ ,oil ,gr4 #a ,! only /atem5t reg>d+ its me?od ( prep>ation is ! l9e 8,solution 9 ,cod ,liv] ,oil1 ,norwegian40 ,accord+ to ! promot]s1 8,brom9-,iod90 is3 8,a ,p[]ful ,anti-,tub]cul> ,ag5t = ,hypod]mic ,use 9 ,pulmon>y & ,l>yngeal ,tub]culosis4 ,useful 9 o!r =ms ( ,tub]cul> ,diseases1 & 9 ,non-,tub]cul> ,pulmon>y ,diseases ( a ,sub-,acute or ,*ronic ,nature40 ,! 8=mula10 9 ! =m 9 :i* ! manufactur]s publi% x1 is ei!r impossible or mean+less1 accord+ to ! int]pretation t may be giv54 ,x is impossible if x is int5d$ to indicate ! actual composition ( ! product because t w\ld mean t ! oil is alleg$ to conta9 free or uncomb9$ iod91 brom9 & phosphorus4 ,bo? on !oretical gr\nds & also 9 ! light ( ! f9d+s ( ! ,*emical ,laboratory ( ! ,am]ican ,m$ical ,association1 x is n possible t all ^! con/itu5ts c be pres5t 9 ! free /ate4 ,! =mula is mean+less if x is int5d$ to convey ! idea1 m]ely1 t iod91 brom91 phosphorus1 ?ymol1 m5?ol & /]iliz$ oil are comb9$ to =m 8,brom9-,iod940 ,9 ! abs5ce ( any details ( ! me?od ( manufacture1 x is futile to attempt to pass judgm5t on ! actual composition ( ! prep>ation4 ,! use ( an almo/ id5tical product 7said1 h[ev]1 to conta9 only #a_/b gra9 iod9 to ea* fluidram7 0 describ$ 9 #aijh by ,dr4 ,+raham ( ,b+hamton1 ,n4 ,y41 9 8,five ,ye>s ,successful ,exp]i5ce ) a ,special ,mode ( ,treat+ ,pulmon>y ,tub]culosis40 ,9 #aiaj ,! ,j\rnal#a *>act]iz$ ! prep>ation z 8"o ( ! innum]able #8treatm5ts' = pulmon>y tub]culosis t h aris51 _h _! day &1 m or less gracefully1 retir$40 ,if ! prep>ation _h value = ! purpose = :i* x is recomm5d$1 its use dur+ ^! twelve ye>s %\ld h secur$ its g5]al recognition4 ,!re is no satisfactory evid5ce ( its !rapeutic efficacy4 ,! ,c\ncil refus$ recognition to ,brom9-,iod9 ,comp4 &1 aft] submitt+ ?is report to ! ,brom9-,iod9 ,*emical ,company1 au?oriz$ its publication4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,dec4 #bc1 #aiaf47 ,,ammonium ,,hypophosphite ,,omitt$ ,,f ,n4 ,n4 ,r4 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,ammonium hypophosphite 0 admitt$ to ,new & ,non(ficial ,rem$ies 9 #aijh z a prelim9>y /ep 9 ! consid]ation ( a prep>ation conta9+ x--8,g>dn]'s ,syrup ( ,ammonium ,hypophosphite0--because ! ,c\ncil /&>dizes un(ficial products be=e consid]+ prep>ations or mixtures ( ^!4 ,! !rapeutic use ( hypophosphites be+ irrational 7see1 8,! ,hypophosphite ,fallacy10 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry1 ,! ,j\rnal1 ,sept4 #b1 #aiaf1 p4 #gfj71 ! salt1 ammonium hypophosphite1 des]ves cont9u$ recognition only on condition t ?is salt ( ammonium is sup]ior to o!r salts f :i* may be obta9$ ! effect ( ! ammonium radical4 ,x has be5 claim$ t ammonium hypophosphite has a less objectionable ta/e ?an o!r ammonium salts us$ = simil> purposes4 ,?is claim w\ld m]it s]i\s consid]ation if 9 addition to be+ less objectionable to ! ta/e1 ! effects ( ammonium hypophosphite 7 equal to or m desirable ?an ! (ficial ammonium salts4 ,!re is no evid5ce t ?is condition is met by ! hypophosphite salt4 ,ammonium hypophosphite has long be5 kn[n1 yet x is n (ficial 9 ! ,au/rian1 ,belgian1 ,briti%1 ,fr5*1 ,g]man1 ,hung>ian1 ,italian1 ,sw$i%1 ,swiss or ,unit$ ,/ates ,ph>macopeias4 ,nei!r is x m5tion$ 9 ! lead+ textbooks on mat]ia m$ica1 ph>macology or !rapeutics4 ,9 %ort x appe>s to be an in/ance ( an obscure & sup]flu\s salt select$ = propriet>y exploitation4 ,s9ce ! cont9u$ recognition ( ammonium hypophosphite w\ld t5d to p]petuate ! hypophosphite fallacy1 & because !re is no evid5ce support+ its advantage z a means ( secur+ ! effect ( ammonium salts ! ,c\ncil direct$ its omission f ,new & ,non(ficial ,rem$ies4--7,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiaf1 p4 #ea47 ,,alphozone ,,omitt$ ,,f ,n4 ,n4 ,r4 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! foll[+ adv]tisem5t appe>$ 9 ! ,new ,idea 7,septemb]1 #aiaf71 a h\se organ ( ,fr$]ick ,/e>ns ,co41 ! proprietors ( ,alphozone3 ,illu/ration ,9 ! light ( our pres5t k ! claim t ,alphozone is a prev5tive ( infantile p>alysis is )\t w>rant & ! advice t ! public dep5d on x = ?is purpose is repreh5sible & dang]\s4 ,!re=e1 ! ,c\ncil direct$ t ,alphozone be omitt$ f ,new & ,non(ficial ,rem$ies4--7,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiaf1 p4 #ej47 ,,calcium ,,glyc]ophosphate ,,& ,,sodium ,,glyc]ophosphate ,,omitt$ ,,f ,n4 ,n4 ,r4 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,calcium glyc]ophosphate & sodium glyc]ophosphate 7 accept$ = ,new & ,non(ficial ,rem$ies *iefly 9 ord] t ^! products might be /&>diz$4 ,^! mixtures n[ be+ def9$ 9 ! new edition ( ! ,u4 ,s4 ,ph>macopeia1 ?is reason = includ+ !m 9 ,n4 ,n4 ,r4 no long] exi/s4 ,! report ( ,m>%all 7,! ,j\rnal1 ,feb4 #ac1 #aiae1 p4 #egc7 :i* has ! endorsem5t ( ! ,c\ncil 7,! ,j\rnal1 ,sept4 #cj1 #aiaf1 p4 #ajcc7 %[s t organic phosphorus comp\nds are split up into inorganic phosphates be=e absorption1 t ! animal organism c syn!size its complex organic phosphorus con/itu5ts f inorganic phosphates & consequ5tly t ! glyc]ophosphates1 s f> z _! phosphorus value is conc]n$1 are n sup]ior to o!r phosphates4 ,9 fact1 sodium & phosphate are m effectively adm9i/]$ z neutral or acid phosphate4 ,x is evid5t t sodium glyc]ophosphate is a sup]flu\s ph>maceutical prep>ation1 p>ticul>ly :5 ! difficulty ( obta9+ a pure product & its high price is consid]$4 ,s f> z its calcium value is conc]n$1 calcium glyc]ophosphate has no advantages ov] su* calcium salts z ! c>bonate1 phosphate1 lactate1 or *lorid4 ,9 view ( ! =ego+1 ! ,c\ncil direct$ t sodium glyc]ophosphate & calcium glyc]ophosphate be omitt$ f ,new & ,non(ficial ,rem$ies4--7,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiaf1 p4 #eb47 ,,g>dn]',s ,,syrup ,,( ,,ammonium ,,hypophosphite ,,omitt$ ,,f ,n4 ,n4 ,r4 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,9 recognition ( ! consid]able revision ( ! !rapeutic claims made by ! manufactur]1 ,g>dn]'s ,syrup ( ,ammonium ,hypophosphite 0 reta9$ 9 ,new & ,non(ficial ,rem$ies1 #aiaf1 & ! proprietor advis$ ( ?is provisional ret5tion4 ,9 ! mo/ rec5t adv]tis+ = ?is ammonium hypophosphite syrup ! claim is made3 8,besides be+ an active expectorant ,syrup ( ,ammonium ,hypophosphite 7,g>dn]7 is useful z an alt]ative & resolv5t & by virtue ( its phosphorus elem5t1 :i* is 9 ! =m ( a hypophosphite1 ,,ph,o1 has a tonic value40 ,z detail$ 9 ! report ( ! ,c\ncil 8,! ,hypophosphite ,fallacy0 7,! ,j\rnal1 ,a4 ,m4 ,a41 ,sept4 #b1 #aiaf1 p4 #gfj7 c>eful /udies %[ t ! hypophosphites are devoid ( ! 8alt]ative0 & 8tonic0 actions claim$ by ! manufactur] ( ,g>dn]'s ,syrup ( ,ammonium ,hypophosphite4 ,accord+ly ! ,c\ncil vot$ to omit ,g>dn]'s ,syrup ( ,ammonium ,hypophosphite f ,new & ,non(ficial ,rem$ies & au?oriz$ publication ( ?is report4--7,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiaf1 p4 #ee47 ,,glut5 ,,products ,,made ,,by ,,! ,,kellogg ,,food ,,company ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,= ov] two ye>s ! ,c\ncil has _h "u consid]ation c]ta9 products (f]$ = ! use ( diabetics by ! ,kellogg ,food ,company ( ,battle ,creek1 ,mi*4 ,^! are3 ,pure ,glut5 ,biscuit4 ,pure ,glut5 ,meal4 #dj p] c5t4 ,glut5 ,biscuit4 #dj p] c5t4 ,glut5 ,fl\r4 #dj p] c5t4 ,glut5 ,meal4 #bj p] c5t4 ,glut5 ,meal4 ,! ,c\ncil f\nd ^! products ineligible = ,new & ,non(ficial ,rem$ies because ! /atem5ts ( composition 7p>ticul>ly ( />* cont5t7 7 insuffici5t & because ! exploitation ( ! products to ! laity 0 objectionable4 ,june #ba1 #aiae1 ! company promis$ to place a /atem5t ( ! />* cont5t on ! package ( ea* glut5 product1 to place on ! glut5 fl\r sacks a caution t diabetics use ! fl\r only on ! advice ( _! physicians1 & to revise its adv]tis+ 9 accordance ) ! sugge/ions ( ! ,c\ncil4 ,no?+ fur!r hav+ be5 he>d f ! company1 9 ,april1 #aiaf1 specim5s ( ! product 7 obta9$1 ?r\gh a layman1 direct f ! ,kellogg ,food ,company4 ,^! specim5s1 toge!r ) ! adv]tis+ matt] receiv$ at ! same "t1 & also a lett] ( advice f ! company to ano!r layman1 7 s5t to ! ,c\ncil's ref]ee1 ^: report foll[s4 ,z w be se51 ! ref]ee f9ds t ! am\nts ( c>bohydrates conta9$ 9 ,pure ,glut5 ,fl\r1 #dj p] c5t4 ,glut5 ,fl\r & ,pure ,glut5 ,meal are great] ?an ! am\nts claim$ 9 ! company's publi%$ analyses2 t 9 ! two fir/ m5tion$ ! am\nts ( prote9 are less ?an ! am\nts claim$2 t exagg]at$ claims are made on all ! labels & 9 ! adv]tis+ lit]ature1 & t ! company prescribes directly to ! pati5t4 ,! foll[+ report 0 s5t to ! ,kellogg ,food ,company = consid]ation4 ,9 reply ! firm /at$ t a revision ( its adv]tis+ 0 "u consid]ation b w\ld make no /atem5t z to h[ soon ?is revision w\ld be c>ri$ into effect4 ,z ! consid]ation _h already consum$ two ye>s1 ! ,c\ncil decid$ to give ! pr(ession ! facts & au?oriz$ publication ( ! report4 ,at ! same "t ! ,kellogg ,food ,company 0 advis$ t its products w\ld be consid]$ fur!r :5ev] any submitt$ evid5ce w>rant$ ?is4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,ref]ee's ,report ,i submit h]e) my report on c]ta9 foods (f]$ by ! ,kellogg ,food ,company = ! use ( diabetics4 ,i %all discuss ^! products f ! /&po9t ( ! claims made on ! label1 f ! /&po9t ( ! company t[>d nonm$ical treatm5t z reveal$ 9 a lett] to a layman1 & la/ly1 on ! basis ( ! claims made = ! foods 9 ! company's lit]ature4 ,,claims ,,made ,,on ,,! ,,label ,,pure ,,glut5 ,,biscuit ,ref]ee ,company ,wat] #h4cj #e-aj ,a% #b4jd #a-b ,prote9 7,n #e4g7 #gc4hg #ge-hj ,fib] #j4ab #b4d-c ,c>bohydrates #ad4hd #j-e ,fat #j4ha #j4be-j4gj ,/>* #d4jb #j-e ,! sample analyz$ does n conta9 ! am\nt ( prote9 claim$ = x4 ,x also conta9s m />* ?an "o might suspect f ! company's analysis4 ,a m cons]vative claim w\ld be 8/>* less ?an #e p] c5t40 ,! company makes ! error ( us+ ! t]ms 8/>*0 & 8c>bohydrates0 z synonym\s4 ,if ! maximum figures ( ! company's analysis are us$1 ! c>bohydrates w\ld am\nt to #e p] c5t41 :]eas ,i f9d #ad4hd p] c5t4 ,! claim on ! label 8,gu>ante$ to conta9 less ?an #e p] c5t4 ( c>bohydrates0 is incorrect4 ,! next claim1 8,ea* ounce ( ?is glut5 conta9s #bc grams ( prote9 & repres5ts #ie calories0 is approximately correct1 z my analysis %[s #bj4i grams ( prote9 & #ajc calories4 ,! foll[+ rem>ks "u 8,vegetable ,prote9s0 are 9 my judgm5t exagg]at$3 8,lead+ au?orities are n[ agre$ t meat1 fi%1 eggs & o!r animal prote9s are greatly inf]ior to vegetable prote9s 9 diabetes1 (t5 increas+ ! sug> output & ! dang]\s acidosis :i* leads to diabetic coma4444 ,aft] _m ye>s ( exp]im5tation1 we h succe$$ 9 p]fect+ a process :]eby ! c>bohydrates are exclud$40 ,9 ?is connection1 von ,noord51 :om ! company con/antly quotes1 says3 8,9 ! slight] =ms 7( diabetes71 ! influ5ce ( meat album9s is n great & x is difficult to demon/rate ! reaction ( ! pati5t to diff]5t =ms ( album94 ,x may be necess>y to add m album9 ?an ! pati5t c actually take be=e glycosuria indication is react$4444 ,once a m$ium am\nt ( album9 is exce$$1 say #gj to #hj grams1 ! glycosuria increases1 no matt] :at ! type ( album9 is40 ,my analysis also %[s t ! c>bohydrates are n exclud$ f ?is food z claim$ above4 #dj ,,p] ,,c5t4 ,,glut5 ,,biscuit ,ref]ee ,wat] #h4ej ,a% #a4dh ,prote9 7,n #e4g7 #da4ae ,fib] #j4jh ,c>bohydrates #dg4ha ,fat #j4ih ,/>* #cf4ih ,no analysis is suppli$ by ! company1 b ?is may be call$ prop]ly a 8#dj p] c5t4 ,glut5 ,biscuit40 ,! company claims1 h[ev]1 t ?is is 8,be/ = ,diabetics10 :i* is n true4 ,"h1 z 9 ! case ( 8#dj p] c5t4 ,glut5 ,fl\r10 ! company's label attributes to 8,dr4 ,wm4 ,osl] 9 #8,practice ( ,m$ic9e1'0 ! foll[+ quotation3 8,( ,glut5 ,foods1 _m are v unpalatable1 o!rs are frauds4 ,a ,good ,glut5 ,fl\r is made by ! ,battle ,creek ,sanat>ium ,co41 ,mi*40 ,i h no way ( kn[+ to :i* glut5 fl\r ( ! company ,dr4 ,osl] _h ref]5ce4 ,! 8,pure ,glut5 ,meal0 might be call$ prop]ly a 8good glut5 fl\r10 b ?is 8#dj p] c5t4 ,glut5 ,fl\r0 is no bett]1 & no worse1 ?an ! av]age glut5 fl\r on ! m>ket4 ,! quotation f ,osl] gives an entirely false impression4 #dj ,,p] ,,c5t4 ,,glut5 ,,fl\r ,ref]ee ,company ,wat] #h4fb #e-aj ,a% #j4hi #j4e-a ,prote9 7,n #e4g7 #cc4fc #dj-de ,fib] #j4jh #a-c ,c>bohydrates #ee4ce #dj-de ,fat #a4dc #j4b-j4e ,/>* #dh4jd 444 ,my analysis %[s #f4cg p] c5t4 less prote9 ?an ! company's m9imum1 & #aj4ce m c>bohydrates ?an _! maximum4 ,9 pa/ ye>s ,i h f\nd ! prote9 9 ?is br& to range f #ce4j to #db4i p] c5t4 7us+ ! factor #e4g74 ,x is true t ! manufactur] does n /ate :at prote9 factor is us$ 9 8 report$ analysis1 b z 9 f\r o!r br&s #e4g is us$1 x is fair to assume t ! same factor applies to ?is z well4 ,at lea/ su* %\ld be ! case1 z o!rwise ! manufactur]'s analyses w\ld be mean+less4 ,ev5 us+ ! factor #f4be ?is lat] sample conta9s only #cf4hh p] c5t4 ( prote94 ,! foll[+ /atem5t1 9 my judgm5t1 z appli$ to a food conta9+ ov] #dh p] c5t4 ( />*1 does n hold wat]3 8,?is food is ( special s]vice 9 cases ( ,glycosuria & 9 ! mild] =ms ( ,diabetes40 ,) ?is br& z ) 8#dj p] c5t4 ,glut5 ,biscuit0 ! manufactur] aga9 uses ! mislead+ quotation f ,osl]4 #dj ,,p] ,,c5t4 ,,glut5 ,,meal ,ref]ee ,company ,wat] #g4cj #e-aj ,a% #a4cf #a-b ,prote9 7,n #e4g7 #da4ee #dj-de ,fib] #j4aj #a-b ,c>bohydrates #dh4eh #dj-de ,fat #a4aa #j4b-j4e ,/>* #cf4ei #dj-de ,! claim$ analysis is ju/ifi$ by my f9d+s4 ,i mu/ take exception1 h[ev]1 to ! foll[+ /atem5t3 8,prep>$ ) great c>e f a good grade ( ,spr+ ,:eat1 by our special process1 :i* pres]ves ! natural food prop]ties ( ! product40 ,! company evid5tly tries to c>ry wat] on bo? %\ld]s1 on ! "o h& claim+ a r$uction 9 ! />* cont5t1 :ile on ! o!r claim+ ! pres]vation ( all 8! natural food prop]ties40 #bj ,,p] ,,c5t4 ,,glut5 ,,meal ,ref]ee ,company ,wat] #g4fe #e-aj ,a% #a4bb #a-b ,prote9 7,n #e4g7 #bd4fh #bj-cj ,fib] #j4ab #a-b ,c>bohydrates #fe4da #fe-gj ,fat #j4ib #a-b ,/>* #ea4bd #fe-gj ,! company's analysis is confirm$4 ,z ! company claims directly t ?is is 8,n ,a ,diabetic ,food10 any criticism ( its use = t purpose is dis>m$4 ,h[ev]1 aga9 exception mu/ be tak5 to ! /atem5t t 8! natural food prop]ties ( ! product0 are pres]v$4 ,,pure ,,glut5 ,,meal ,ref]ee ,company ,wat] #d4fj #e-aj ,a% #j4if #a-b ,prote9 7,n #e4g7 #gf4gh #ge-hj ,fib] #j4jh #a-c ,c>bohydrates #af4gg #j-e ,fat #j4ha #j4be-j4gj ,/>* #f4gg #j-e ,! m9imum claim z to prote9 is ju/ifi$4 ,aga9 ! company confuses c>bohydrates & />*1 & ! food in/ead ( conta9+ f #j to #e p] c5t4 ( 8c>bohydrates 7/>*70 actually conta9s #af4gg p] c5t4 ( c>bohydrates1 ( :i* #f4gg p] c5t4 is />*4 ,once m ! /atem5t t 8! natural food prop]ties0 are pres]v$ is untrue z appli$ to a :eat product depriv$ ( mo/ ( its />*4 ,9 ju/ice to ! company1 x %\ld be not$ t on ! labels ( 8,pure ,glut5 ,biscuit0 & 8,pure ,glut5 ,meal0 appe>s ! w>n+3 8,e p]son suff]+ f diabetes %\ld be "u ! c>e ( an exp]i5c$ physician10 & on ! label ( 8#dj p] c5t4 ,glut5 ,meal10 8,p]sons suff]+ f diabetes %\ld use ?is food only on ! advice ( a physician40 ,on ! o!r h&1 ! sugge/ion on ! label ( 8,pure ,glut5 ,meal10 8,write = a copy ( ,diabetic ,foods & ,h[ to ,use ,!m0 is a m or less direct invitation to self-treatm5t4 ,moreov]1 a lett] dat$ ,may #i1 #aiaf1 app>5tly dictat$ = ! ,kellogg ,food ,company by "o ,ru? ,fr5*1 9 reply to an inquiry f a layman1 gives direct advice ) no ref]5ce :atev] to a physician4 ,,claims ,,made ,,9 ,a ,,lett] ,,to ,a ,,layman ,9 addition to ?is inconsi/5t attitude ! lett] makes c]ta9 cle> mis/atem5ts1 z foll[s3 8#dj p] c5t4 ,glut5 ,fl\r actually conta9s #dj p] c5t4 ( pure ,glut51 mak+ x a p]fectly safe article ( diet 9 all b ! grave/ cases ( diabetes4 ,f our ,glut5 ,fl\r excell5t bread1 gems & puffs are made t p]fectly satisfy ! crav+ = bread ) no h>mful results40 ,?is fl\r conta9s #cc4fc p] c5t4 ( glut51 n #dj p] c5t42 x is n 8a p]fectly safe article ( diet 9 all b ! grave/ cases ( diabetes10 = if "o reads ! lit]ature correctly1 />* re/riction is m necess>y 9 mild ?an 9 sev]e cases ( diabetes4 ,fur!rmore1 ! bread1 gems & puffs made f su* a fl\r d n 8satisfy ! crav+ = bread ) no h>mful results40 ,9 ! next p>agraph ( ! lett]1 undue emphasis is laid on ! 8objectionable prop]ties0 ( fle% foods1 a /atem5t only 9 accord ) ! t5ets ( extreme veget>ians4 ,i also d\bt v mu* :e!r ! /atem5t is true t 8"u a diet ( our diabetic foods ! ?ir/ to :i* diabetics are s (t5 subject is usually v mu* reliev$40 ,9 ! next p>agraph ! ass]tion is made t 8,! diet indicat$ 444 is 9 keep+ ) ! ideas ( ! highe/ m$ical au?orities4444 ,meat is entirely exclud$ f ! diet>y40 ,my read+ ( ! lit]ature does n %[ t ! lead+ au?orities take any su* position4 ,lat] on ref]5ce is made to von ,noord5's claim z to ! sup]iority ( vegetable ov] animal prote9s1 :i* ,i h already discuss$ "u 8,pure ,glut5 ,biscuit40 7,c]ta9 deta*$ s5t5ces ( von ,noord5 might ju/ify su* a /atem5t1 b a read+ ( all he says on ! subject leads to a v diff]5t conclusion47 ,,claims ,,made ,,9 ,,an ,,adv]tis+ ,,booklet ,! :ole booklet is writt5 f ! /&po9t ( an extreme veget>ian1 & !re=e is (t5 mislead+ 9 its conclusions4 ,page #e4 8,! rese>*es ( ,ogata & o!rs h %[n t cane sug> is a less :olesome food ?an ! natural sug>s f\nd 9 fruits & produc$ 9 ! body by ! dige/ion ( />*1 t is1 fruit sug>s & malt sug>s40 ,9 opposition to ?is ,i quote f von ,noord51 _! own au?ority1 8,die ,zuck]krankheit und ihre ,beh&lung10 ,b]l91 #aiaj1 page #bgj3 8,t levulose1 milk sug> & inul9 are m useful ?an ! o!r c>bohydrates is a common op9ion1 b ! importance ( _! use 9 practice does n correspond ) ! !ory4 ,9 light cases ! =m ( c>bohydrates makes little diff]5ce2 9 sev]e cases ! advantage f us+ levulose1 milk sug>1 etc41 is only slightly great] ?an f us+ bread & fl\r4444 ,only 9 c]ta9 cases does x appe> to me t ! special =m ( c>bohydrates possesses any p>ticul> significance40 ,on page #ib ( ! same "w von ,noord5 tells u t ( ! c>bohydrates dextrose is ! wor/1 ) maltose almo/ z bad 79 spite ( ! fact t ,kellogg exploits 8 8,meltose10 ! 8new c>bohydrate10 z ( special value = diabetics74 ,he also says t levulose increases glycosuria only ab\t half z mu* z dextrose1 :5 us$ occasionally1 b ) long use x is z bad z dextrose & />*4 ,page #e4 ,! company ref]s to sug> z 8possibly also caus+ diabetes40 ,sug> or any o!r c>bohydrate may "u diabetic conditions cause an increase ( glucose 9 ! ur9e1 b ,i d n believe t any food or any diet c cause diabetes4 ,page #g4 8,t ! l>ge use ( meat & eggs is n only detrim5tal b positively dang]\s 9 _m cases ( diabetes is n[ a well kn[n & recogniz$ fact40 ,! diet>ies ( well kn[n au?orities on diabetes are n 9 h>mony ) ?is /atem5t4 ,page #ac4 8,x has be5 discov]$ t ! complete suppression ( c>bohydrates f ! diet>y is n only unnecess>y b is highly detrim5tal & ev5 dang]\s40 8,! complete suppression ( c>bohydrates f ! diet>y0 is ! only means ! physician has to det]m9e ! diabetic's c>bohydrate tol]ance4 ,if c>bohydrate-poor foods are s 8highly detrim5tal & ev5 dang]\s10 :y does ! company exploit foods l 8,pure ,glut5 ,fl\r0 & 8,pure ,glut5 ,biscuit10 ^: *ief claim to excell5ce is _! comp>ative fre$om f c>bohydrates8 ,page #ag4 8,cream is an emulsion1 &1 ) ! exception ( egg yolk1 is ! only =m 9 :i* animal fat is f\nd 9 an emulsifi$ /ate40 ,milk1 ,nature's mo/ wond]ful emulsion1 is app>5tly ov]look$4 ,page #ai4 8444 ^! foods 444 w be f\nd ( great value 444 especially z sub/itutes = ! breads & meats :i* are ! mo/ objectionable features ( ! ord9>y diet1 & :i* %\ld1 z f> z possible1 be int]dict$ 9 ?is class ( cases40 ,?is is simply special plead+ = ! ,kellogg veget>ian diet4 ,page #ai4 8,our glut5s 444 are all ?or\ghly /&>diz$1 s t 9 _! use ! physician & ! pati5t "k j ! am\nt ( />* eat540 ,?is /&>dization is l>gely my?ical4 ,= in/ance1 8,pure ,glut5 ,biscuit0 claims #j to #e p] c5t4 8c>bohydrates 7/>*710 :]eas ,i f9d #ad4hd p] c5t4 c>bohydrates ) #d4jb p] c5t4 />*4 8#dj p] c5t4 ,glut5 ,fl\r0 claims #dj p] c5t4 glut5 & #dj to #de p] c5t4 c>bohydrates1 :]eas ,i f9d #cc4fc & #ee4ce p] c5t41 respectively4 8,pure ,glut5 ,meal0 claims #j to #e p] c5t4 8c>bohydrates 7/>*70 :]eas ,i f9d #af4gg p] c5t4 c>bohydrates & #f4gg p] c5t4 />*4 ,i h a record ( six analyses ea* ( 8#dj p] c5t4 ,glut5 ,fl\r0 & 8#dj p] c5t4 ,glut5 ,biscuit10 :i* %[ ! holl[ness ( ?is claim ( 8/&>dization40 ,! fl\r %[$ #cc4f1 #ce4j1 #db4i1 #cf4h1 #ce4f1 & #dj4i p] c5t4 ( prote91 ) f #dj4h to #ee4d p] c5t4 ( c>bohydrates2 ! biscuits #cb4g1 #cc4b1 #ci4e1 #dc4c1 #cc4i1 & #da4b p] c5t4 ( prote91 ) f #da4a to #ed4j p] c5t4 ( c>bohydrates4 ,9 fact1 my exp]i5ce %[s t ! ,kellogg products are m poorly 8/&>diz$0 ?an mo/ ( ! diabetic foods on ! m>ket4 ,page #bj4 8,may be made to c>ry a l>ge am\nt ( fat 9 ! =m ( butt]1 a mo/ desirable ?+ 9 ! treatm5t ( diabetes10 :ile on page #af ! company claims t 9 an exp]im5t ( ,m9k[ski on a dog1 butt] 8pass$ ?r\gh ! body )\t *ange1 none be+ absorb$02 ^! are c]ta9ly contradictory /atem5ts4 ,! explanation is t on ! "o page ! company is exploit+ its biscuits1 & on ! o!r its nut prep>ations4 ,page #bj4 ,aga9 ! incorrect claim is made = 8#dj p] c5t4 ,glut5 ,fl\r0 t 8we believe ?is to be ! only /&>diz$ glut5 fl\r made40 ,page #ba4 ,! claim is made t fle% foods are 8objectionable on acc\nt ( ! l>ge am\nts ( ptoma9s & tox9s :i* !y conta940 ,i 0 n aw>e t fre% meats conta9$ any ptoma9s :atev]4 ,on ! same page ! claim is aga9 made t by ! use ( ! ,kellogg nut foods 8diabetics lose _! ?ir/10 a claim :i* ,i ?9k is m ?an d\btful4 ,page #bb4 8,nuts are a :ole food1 conta9+ all ! elem5ts requir$ = ! p]fect nutrition ( ! body40 ,a m>k$ *>act]i/ic ( nuts is t !y are n 8a :ole food10 z ) ! exception ( a few v>ieties1 su* z ! *e/nut1 !y are extremely poor 9 c>bohydrates1 :i* fact gives !m _! value 9 ! diabetic diet4 ,page #bc4 8,) ! exception ( ! potato1 ! beet & ! c>rot1 vegetables conta9 little sug> or />*40 ,corn1 beans & peas are all vegetables :i* are relatively high 9 c>bohydrates1 & = ?is reason are specifically exclud$ f ! diabetic's diet>y4 ,f ! =ego+ consid]ations ,i w\ld recomm5d t ! company's analyses ( 8#dj p] c5t4 ,glut5 ,biscuit10 8#dj p] c5t4 ,glut5 ,meal10 & 8#bj p] c5t4 ,glut5 ,meal0 be accept$ z correct4 ,be=e ! ,c\ncil c accept any ( ^! products1 ! foll[+ /eps %\ld be tak53 ,! company on all its labels %\ld correct ! impression t 8c>bohydrates0 & 8/>*0 are synonym\s t]ms4 ,! labels ( all ! prep>ations exam9$ %\ld be *ang$ 9 accordance ) ! criticisms giv5 above4 ,9 all cases 9 :i* analytic data are giv51 x w\ld be pref]able to /ate only ! m9imum ( prote9 & ! maximum ( c>bohydrates4 ,! booklet1 8,practical ,sugge/ions ,ab\t ,diet 9 ,diabetes10 %\ld be radically *ang$ along ! l9es not$ above4--7,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiaf1 p4 #ef47 ,,iodo-,,mangan ,,omitt$ ,,f ,n4 ,n4 ,r4 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,iodo-,mangan1 made by ! ,*emis*e ,fabrik ,helf5b]g ,a4 ,g41 ne> ,dresd51 ,g]many1 & sold 9 ! ,unit$ ,/ates by ! ,re9s*ild ,*emical ,company1 ,new ,york1 is a solution said to conta9 iron1 manganese & iod9 9 comb9ation ) peptone4 ,x is claim$ to be a recon/ructive tonic & blood-mak+ adjuvant1 ) favorable action 9 affections ( ! gl&ul> sy/em4 ,x 0 admitt$ to ,new & ,non(ficial ,rem$ies 9 #aijg1 be=e ! ,c\ncil _h adopt$ ! pres5t ,rule #aj1 :i* provides t no article %all be admitt$ to ,new & ,non(ficial ,rem$ies :i*1 because ( its unsci5tific composition1 is useless or inimical to ! be/ int]e/s ( ! public or ( ! m$ical pr(ession4 ,9 #aiaa ! ,c\ncil consid]$ ! "q :e!r or n ?is product 0 /ill eligible & decid$ 9 ! end to reta9 x z probably hav+ "s m]it4 ,to det]m9e if ,iodo-,mangan 0 eligible = ,new & ,non(ficial ,rem$ies1 #aiag1 ! ,re9s*ild ,*emical ,company 0 reque/$ to s5d 9 ! curr5t adv]tis+ matt]4 ,z ?is adv]tis+ 0 n s5t 9 & z app>5tly ! product 0 n m>ket$ at ! pres5t "t1 ! ,c\ncil on ,ph>macy & ,*emi/ry vot$ to omit ,iodo-,mangan f ,new & ,non(ficial ,rem$ies4 ,at ! same "t ! ,re9s*ild ,*emical ,company 0 in=m$ t ! prep>ation might be submitt$ = reconsid]ation at any "t4--7,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiaf1 p4 #fd47 ,,liquid ,,albol5e ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,z n[ m>ket$1 ,liquid ,albol5e 7,mc,kesson & ,robb9s1 ,new ,york71 is claim$ to be made only f g5u9e ,russian oil & h5ce to possess di/9ct advantages ov] 8444 ,oils purport+ to be ,russian1 mo/ ( :i* are imp]fectly purifi$ & _m ( :i* are positively dang]\s = cont9u$ use40 ,on ! o!r h&1 a %ort "t ago1 ,mc,kesson & ,robb9s claim$ t ,liquid ,albol5e 0 !n available4 8444 ,( z high a quality z we _h suppli$ be=e ! ,european ,w>4 ,?anks to ! rese>* & sci5tific a*ievem5t ( ,our ,*emi/s1 we are n[ able to (f] ,,liquid ,,albol5e1 us+ z a base a specially ref9$ ,dome/ic ,oil t is 9 e way suitable = m$ic9al purposes1 & hav+ ! same viscosity z ,russian ,oil40 ,! adv]tis+ matt] sugge/s ! promiscu\s1 ?\ghtless & irrational use ( ,liquid ,albol5e & ( a numb] ( ,albol5e prep>ations by extravagant claims1 su*1 = example1 z ! foll[+3 8,albol5e w nev] fail to br+ a free1 easy /ool1 no matt] :at condition may be pres5t1 f ob/9ate atony ( ! b[el to fissure1 fi/ula1 or ev5 malignant disease1 & 9 spite ( ! failure ( ord9>y purgatives to :i* ! pati5t may h become habituat$4444 8,aromatic ,liquid ,albol5e is actually ! fir/ laxative pres5t$ to ! m$ical pr(ession t seems to h no drawback4444 8,x w n h be5 lo/ ^u ! physician :o has read ! rem>ks on ! use ( ,aromatic ,liquid ,albol5e to regulate ! b[els 9 surgical cases1 t !re are _m in/ances :]e x w\ld prove equally valuable dur+ ! treatm5t ( acute diseases4 ,9 ! exan!mata1 9 pneumonia1 = example1 to cite only a few ( ! conditions :]e x may be us$ to advantage1 an absolutely reliable laxative t w n 9 any way weak5 or di/ress ! pati5t1 pres5ts obvi\s sup]iority to any ( ! ag5ts h]et(ore 9 common use40 ,! ,c\ncil held ,liquid ,albol5e ineligible because ! product is m>ket$ 9 a way to enc\rage its indiscrim9ate & irrational use by ! public 7,rule #d7 & because unw>rant$ !rapeutic claims are made = x 7,rule #f74--7;,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiaf1 p4 #fe47 ,,naphey',s ,,m$icat$ ,,ut]9e ,,waf]s ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,naphey's ,m$icat$ ,ut]9e ,waf]s 7 submitt$ to ! ,c\ncil by ! manufactur]s1 ,naphey ,co41 "s ye>s ago & 7 reject$4 ,naphey ,co4 has rec5tly reque/$ reconsid]ation ( ! prep>ation1 & has submitt$ adv]tis+ matt]1 trade packages & sample packages4 ,! label ( ! trade package conta9s ! foll[+3 8,naphey's ,waf]s4 ,= ! local treatm5t ( diseases ( wom51 indicat$ 9 cat>rhal conditions ( ! vag9a1 & ( ! ut]9e c]vix4 ,z a sic6 adjuvant = ! physician to use 9 c>ry+ out treatm5t ( disease ( ! ut]us40 8,z9c ,sulphate1 #c-c_/d gr41 ,sodium ,sulphate1 #c-a_/b gr41 ,sodium ,borate1 #d gr41 ,boric ,acid1 #c_/d gr40 8,naphey ,co41 ,w>r51 ,pa41 ,u4 ,s4 ,a40 8,ea* box conta9s #be waf]s1 suffici5t = ?ree mon?s' treatm5t4 ,price p] box1 #be;c40 ,9 "n1 composition1 & g5]al appe>ance ( ! package1 ,naphey's ,m$icat$ ,ut]9e ,waf]s be> a /rong resemblance to ,micajah's ,m$icat$ ,ut]9e ,waf]s 7,! ,j\rnal1 ,a4 ,m4 ,a41 ,m>* #bf1 #aiaj1 p4 #ajgj74 ,an adv]tis+ pamphlet reads3 8,9 e =m ( leucorrhea ,naphey's ,m$icat$ ,ut]9e ,waf]s are indicat$ 4440 8,:at is true ( leucorrhea is also true ( all o!r functional tr\bles affect+ ! female g5ital canal2 !y are all treat$ be/ by a/r+5ts & antiseptics4 ,& ^!1 to be effective1 mu/ be appli$ 9 prolong$ contact40 ,! implication t all 8functional tr\bles affect+ ! female g5ital canal0 are be/ treat$ by a/r+5t tablets l ,naphey's ,m$icat$ ,ut]9e ,waf]s is an absurdity4 ,! nam+ ( disease conditions on ! label1 ! manife/ly unw>rant$ & exagg]at$ !rapeutic claims1 ! "n1 :i* is non-descriptive ( composition b sugge/ive ( use1 & ! fix$ =mula1 :i* _c rationally be expect$ to give uni=mly satisfactory results 9 ! wide range ( conditions = :i* ! product is recomm5d$1 r5d] ,naphey's ,m$icat$ ,ut]9e ,waf]s ineligible = ,new & ,non(ficial ,rem$ies "u ,rules #d1 #f1 #h & #aj4 ,! report hav+ be5 s5t to ,naphey ,co41 ! manufactur] (f]$1 on condition t ! prep>ation be accept$1 to revise ! adv]tis+ matt] 9 m9or p>ticul>s1 to remove disease names f ! trade package & to adopt ! "n ,naphey's ,waf]s or ,naphey's ,tablets4 ,! ,c\ncil advis$ ,naphey ,co4 t ! propos$ names d n con=m to ! requirem5ts = acceptance 9 ,new & ,non(ficial ,rem$ies because !y d n indicate ! composition ( ?is ph>maceutical mixture1 & moreov]1 t ! r\t9e use ( a complex =mula su* z t ( ^! tablets is irrational4--7,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiaf1 p4 #ff47 ,,nujol ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,nujol1 a liquid petrolatum 7,/&>d ,oil ,company ( ,new ,j]sey1 ,bayonne1 ,n4 ,j471 0 submitt$ to ! ,c\ncil by ! manufactur]s4 ,! ,c\ncil advis$ ! company t1 be=e ,nujol c\ld be made eligible = ,new & ,non(ficial ,rem$ies1 ! adv]tis+ claims made = x mu/ be revis$ to con=m to ! rules ( ! ,c\ncil & ! t]m 8liquid petrolatum0 mu/ be us$ 9 connection ) ! br& designation & giv5 equal prom95ce on ! labels1 adv]tisem5ts & all circul>s4 ,! company !reupon submitt$ a label on :i* ! "n 8,nujol0 appe>$ 9 l>ge r$ lett]s & "u x 9 small lett]s ! words 8,liquid ,petrolatum40 ,?is did n meet ! ,c\ncil's requirem5t ) reg>d to ! "n4 ,moreov]1 ,nujol cont9u$ to be adv]tis$ to ! public "u exagg]at$ & unw>rant$ claims4 ,! =ego+ report 0 s5t to ! ,/&>d ,oil ,company ( ,new ,j]sey1 :i* !reupon submitt$ revis$ adv]tis+ copy4 ,?is copy 0 decid$ly less objectionable ?an ! previ\s adv]tis+ b /ill conta9$ exagg]at$ /atem5ts4 ,! copy = use 9 lay j\rnals p>ticul>ly evid5c$ exagg]ation4 ,obs]vation on _m occasions ( a simil> fact has conv9c$ ! ,c\ncil ( ! inexp$i5cy ( admitt+ to ,new & ,non(ficial ,rem$ies any article :i* is adv]tis$ to ! public4#aja #aja ,s9ce publication ( ?is report ! ,c\ncil on ,ph>macy & ,*emi/ry has revis$ its rule aga9/ recognition ( articles adv]tis$ to ! public s t ?is %all n apply 7a7 to dis9fectants1 g]micides & antiseptics1 provid$ ! adv]tis+ be limit$ to cons]vative recomm5dations = _! use z prophylactic applications to sup]ficial cuts & abrasions ( ! sk9 & to ! muc\s surfaces ( ! m\?1 ph>ynx & nose1 & provid$ !y are n adv]tis$ z curative ag5ts1 & 7b7 to non-m$ic9al food prep>ations1 except :5 adv]tis$ 9 an objectionable mann]4 ,! ,c\ncil held t conflict ) ,rules #c1 #f & #h prev5t$ ! acceptance ( ,nujol & au?oriz$ ! publication ( ?is report4--7,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiaf1 p4 #fh47 ,,pulvoids ,,natrium ,,comp\nd ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,pulvoids ,natrium ,comp\nd 0 submitt$ to ! ,c\ncil by ! ,drug ,products ,company1 ,inc41 ,new ,york1 ) ! /atem5t t ea* pulvoid 7coat$ tablet1 said to be made to dissolve 9 ! inte/9al tract7 repres5ts ! equival5t (3 ,potassium ,nitrate #b-a_/b grs4 ,sodium ,nitrite #a_/b gr4 ,sodium ,bic>bonate #b grs4 ,fl4 ,ext4 ,crataegus ,oxycan?a #a m94 ,nitroglyc]9 #a_/bej gr4 ,accord+ to ! adv]tisem5ts ! tablets are 8indicat$ 9 ! treatm5t ( high blood pressure & all =ms ( hyp]t5sion ( ! c>dio-vascul> sy/em40 ,x is claim$ t ! tablets 8w n irritate ! kidneys40 ,! ,c\ncil1 hav+ submitt$ its objections to ! manufactur] & consid]$ ! firm's reply1 held t ,pulvoids ,natrium ,comp\nd 0 inadmissible to ,new & ,non(ficial ,rem$ies = ! foll[+ reasons3 #a4 ,! claim is made t ! tablets dis9tegrate 9 ! inte/9es2 exp]im5ts conduct$ by ! ,c\ncil indicat$ t 9 mo/ cases !y w\ld be brok5 up 9 ! /oma*4 ,x 0 f\nd t ! tablets 7 visibly *ang$ imm$iately aft] be+ put into ga/ric juice or ev5 into di/ill$ wat]2 !y dis9tegrat$ )9 f ?ree to f\r h\rs1 n only 9 ga/ric juice 7obta9$ f a dog7 at #cg ,c41 b also 9 di/ill$ wat]4 ,x is q usual = solids to rema9 9 ! /oma* = m ?an ?ree h\rs4 ,if !y make _! way out ( ! /oma* 9 less ?an t "t ! ga/ric movem5ts mu/ be s vigor\s z fur!r to ha/5 ! dis9tegration ( ! tablets4 #b4 ,! rules ( ! ,c\ncil require t ! "n ( a ph>maceutical mixture %all indicate ! pot5t +r$i5ts4 ,! "n ( ?is mixture does n indicate ! pres5ce ( ! nitrites1 ! potassium nitrate1 ! bic>bonate or ! extract ( haw?orne & ! nondescriptive "n is likely to lead physicians to use ! tablets )\t fully realiz+ :at !y are giv+4 #c4 ,no evid5ce 0 submitt$ t ! tablets1 z f\nd on ! m>ket1 conta9$ ! am\nt ( sodium nitrite & nitroglyc]9 claim$4 ,t is1 x does n appe> t ! manufactur] *ecks ! sodium nitrite & nitroglyc]9 cont5t by analysis4 ,! ,c\ncil did n det]m9e ! nitrite cont5t ( ! tablets4 ,x ma9ta9s t :5 a manufactur] places a product on ! m>ket ! burd5 ( pro( is on t manufactur] to %[ t ! facts are 9 accordance ) 8 claims = 8 product4 ,fur!r1 ! exam9ation by ! ,c\ncil ( "o or sev]al specim5s ( any comm]cial product 7p>ticul>ly 9 ! case ( nitroglyc]9 prep>ations7 w\ld n be a gu>antee ( ! con/ancy ( its composition s long z ! manufactur] does n himself control ! composition by analysis4 ,! necessity ( su* control ( tablets conta9+ nitroglyc]9 is evid5t f ! report#ajb ( ,l4 ,f4 ,kebl] ( ! ,u4 ,s4 ,bureau ( ,*emi/ry4 ,dr4 ,kebl] said3 #ajb ,j4 ,a4 ,m4 ,a41 ,nov4 #b1 #aiab1 p4 #afjd4 8444 nitroglyc]9 tablets h 9 a majority ( cases be5 f\nd defici5t 9 ! nitroglyc]9 cont5t decl>$40 8444 ^! commodities are manufactur$ l>gely by rule ( ?umb4 ,little *eck+ obta9s 9 _! manufacture & g5]ally no analy/ is employ$40 ,a fur!r pro( t nitroglyc]9 tablets are likely to be defici5t 9 /r5g? is conta9$ 9 ! convictions "u ! ,food & ,drugs ,act ( manufactur]s :o sold tablets bel[ ! decl>$ /r5g?1 record$ f "t to "t 7,notices ( ,judgm5ts ,nos4 #cdje1 #bjei1 #ahdc1 #agii74 #d4 ,!re is no good evid5ce1 exp]im5tal or cl9ical1 to ju/ify ! simultane\s adm9i/ration 9 fix$ proportion ( two vasodilators l sodium nitrite & glyc]yl tr9itrate 7nitroglyc]974 ,also !re is no rational excuse = comb9+ extract ( haw?orne1 :i* is said to h a tonic effect on ! he>t muscle1 ) nitrites1 :i* cause relaxation ( ! vascul> sy/em1 or = ! comb9ation ) ^! con/itu5ts ( potassium nitrate or ( sodium bic>bonate4 ,9 ! abs5ce ( evid5ce = ! comb9ation1 ,pulvoids ,natrium ,comp\nd mu/ be consid]$ an irrational mixture1 ! use ( :i* is a detrim5t to s\nd drug !rapy &1 h5ce1 n admissible to ,new & ,non(ficial ,rem$ies4--7,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiaf1 p4 #fi47 ,,sal(orm ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,a ref]ee submitt$ ! foll[+ report ( ! ,am]ican ,m$ical ,association ,*emical ,laboratory to ! ,c\ncil3 ,,analysis ,,( ,,sal(orm ,sal(orm 7,flexn]7 is adv]tis$ by ! ,rob9son-,pettet ,company ( ,l\isville1 ,ky4 ,9 ! adv]tisem5ts = ! product x is /at$ t3 8,sal(orm is a def9ite *emical comp\nd ! compon5t p>ts ( :i* are ,hexame?yl5e ,tetram9e1 ,salicylic ,acid & ,li?ia40 8,z a ,uric ,acid ,solv5t x is indicat$ 9 ,rheumatism1 ,g\t1 9 ,phosphaturia1 9 ,gravel1 & 9 ,r5al ,colic40 8,z a ,g5ito-,ur9>y ,antiseptic x limits suppuration any:]e along ! ,ur9>y ,tract1 f ! ,kidneys d[n to ! orifice ( ,ure?ra40 ,z1 ev5 aft] dilig5t se>*1 no description ( a comp\nd ( hexame?yl5am9e 7hexame?yl5etetram9e71 salicylic acid & li?ia 0 f\nd 9 *emical lit]ature1 x seem$ probable t ,sal(orm is m]ely a mixture ( hexame?yl5am9e & li?ium salicylate4 ,accord+ly ! sep>ation ( ,sal(orm into its compon5t p>ts by means ( select$ solv5ts 0 attempt$4 ,by triturat+ ! p[d] ) *lor(orm1 filt]+ & evaporat+ ! filtrate1 a residue 0 obta9$ :i* gave satisfactory te/s = hexame?yl5am9e b conta9$ only traces ( salicylic acid or li?ium salicylate4 ,! portion insoluble 9 *lor(orm 0 dissolv$ 9 wat]4 ,! solution gave satisfactory te/s = li?ium salicylate b n = hexame?yl5am9e4 ,f ^! te/s x is evid5t t ,sal(orm is a simple mixture ( hexame?yl5am9e & li?ium salicylate4 ,quantitative exam9ation indicat$ t ! two +r$i5ts1 hexame?yl5am9e & li?ium salicylate1 are pres5t 9 approximately equal am\nts4 ,,ref]ee',s ,,recomm5dation ,! report ( our ,*emical ,laboratory %[s t ,sal(orm is n a def9ite comp\nd z claim$1 b a simple mixture ( hexame?yl5am9 & li?ium salicylate4 ,x is !re=e 9 conflict ) ,rule #a4 ,x is also 9 conflict ) ,rule #f1 = nei!r hexame?yl5am91 li?ium1 nor salicylate are !rapeutically effective 8uric acid solv5ts02 nor w\ld any ( ^! h any effect on 8phosphaturia40 ,! mixture also conflicts ) ,rule #aj2 = x is inadvisable to adm9i/] ! +r$i5ts 9 fix$1 b unkn[n proportions4 ,x is recomm5d$ t ,sal(orm be deem$ inadmissible to ,n4 ,n4 ,r4 ,! ,c\ncil adopt$ ! recomm5dation ( ! ref]ee & au?oriz$ publication ( ?is report4--7,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiaf1 p4 #ga47 ,,secretog5 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,ab\t a ye> ago ! ,c\ncil decl>$ ,secretog51#ajc a product ! active +r$i5t ( :i* 0 /at$ to be 8pancreatic secret90 & adv]tis$ z a rem$y = c]ta9 conditions ( defective dige/ion & assimilation1 to be ineligible = ,new & ,non(ficial ,rem$ies4 ,! reasons = ?is decision 7 /at$ at ! "t z foll[s3 #ajc ,j4 ,a4 ,m4 ,a41 ,may #a1 #aiae1 p4 #aeah4 8#a4 ,no evid5ce has be5 pres5t$ t ! abs5ce ( secret9 is a cause ( ga/ro-inte/9al diseases4 ,x is usually pres5t1 & if n pres5t1 z 9 a*ylia ga/rica1 !re is evid5tly "s comp5sat+ arrangem5t by :i* ! pancreas is /imulat$ to p]=m its regul> functions4 8#b4 ,!re is no evid5ce t secret9 9 any =m is physiologically active :5 adm9i/]$ by m\?40 ,s9ce ,secretog5 0 n ! only s-call$ secret9 prep>ation on ! m>ket1 & s9ce ! use ( secret9 prep>ations 0 recomm5d$ by c]ta9 writ]s1 not)/&+ ! lack ( evid5ce ( its value1 ! ,c\ncil caus$ an exp]im5tal inve/igation ( ! "q to be made4 ,?is 0 c>ri$ out by ,pr(4 ,a4 ,j4 ,c>lson ( ! ,univ]sity ( ,*icago4 ,no secret9 0 f\nd 9 ! comm]cial products exam9$1 namely1 ,secretog5 ,tablets1 ,secretog5 ,elixir & ,duod594 ,fur!rmore1 ,c>lson's results#ajd confirm$ ! ,c\ncil's previ\s conclusion z to ! in]tness ( secret9 adm9i/]$ by m\?4 ,! ,c\ncil endors$ ,pr(essor ,c>lson's f9d+s4#aje #ajd ,c>lson4 ,a4 ,j42 ,leb5sohn1 ,j4 ,e41 & ,pe>lman1 ,s4 ,j42 ,has ,secret9 a ,!rapeutic ,value8 ,j4 ,a4 ,m4 ,a41 ,jan4 #ae1 #aiaf1 p4 #agh4 ,reports ,c\ncil on ,ph>m4 & ,*em41 #aiae1 p4 #ih4 #aje ,s-,call$ ,secret9 ,prep>ations1 ,j4 ,a4 ,m4 ,a41 ,jan #ae1 #aiaf1 p4 #bjh2 ,reports ,c\ncil on ,ph>m4 & ,*em41 #aiae1 p4 #if4 ,! ,g4 ,w4 ,c>nrick ,company has repli$ to ! publication ( ?is report 9 ! lett] pr9t$ bel[4 7,a portion ( ?is lett]1 :i* consi/s ( a communication f an unnam$ correspond5t ( ! ,g4 ,w4 ,c>nrick ,company & ! company's comm5t !reon1 has be5 omitt$47 ,! ,c\ncil (f]$ to publi% ?is if ! ,c>nrick ,company w\ld furni% ! "n ( ! writ]4 ,?is x has n done4 ,z w be se51 ! company n[ %ifts gr\nd1 ab&on+ entirely ! claim t ,secretog5 conta9s secret94 ,! ,c\ncil has au?oriz$ publication ( ! lett] 7omitt+ ! "p j m5tion$71 toge!r ) ! comm5t t foll[s4 ,w4 ,a4 ,,puckn]1 ,secret>y4 8,! ,c\ncil on ,ph>macy & ,*emi/ry ( ! ,am]ican ,m$ical ,association4 8,g5tlem53--,! op9ion ( ! ,c\ncil & ! contribution by ,pr(essor ,c>lson :i* appe>$ 9 ,! ,j\rnal ( ! ,am]ican ,m$ical ,association = ,jan4 #ae1 #aiaf1 h be5 read by u ) int]e/4 ,! column ( ,curr5t ,comm5t deal+ ) #8,tig]-,bone ,!rapy & ,cl9ical ,exp]i5ce' has appeal$ to our good nature &1 "u ! circum/ances1 our s5se ( humor4 8,pr(essor ,c>lson seems to h q well e/abli%$ t ! s-call$ secret9 prep>ations d n conta9 secret9 to any appreciable ext5t1 & t !y are in]t 9 laboratory exp]im5ts on normal animals4 ,at ! same "t1 to d away ) an app>5t discrim9ation on ! "p ( ! managem5t ( ! ,c\ncil1 x w\ld h be5 well if ,pr(essor ,c>lson _h includ$ ! s-call$ secret9 prep>ations belong+ to ano!r well-kn[n firm :i* m>kets su* a product4 ,?is discrim9ation has already be5 ref]r$ to by u4 8,_h ,pr(essor ,c>lson /opp$ at ! det]m9ation ( ! !rapeutic availability ( secret9 giv5 by m\?1 8 "w might h be5 accept$ )\t comm5t1 ev5 if we %\ld h ?\ght x advisable to object to ! matt] publi%$ by ! ,c\ncil4 ,b ! pr(essor w5t beyond 8 prov9ce entirely :51 9 comm5t+ on ! f9d+s obta9$ by us+ ,secretog5 cl9ically1 he said3 #8,x is1 p]haps1 imp]t95t = laboratory m5 to comm5t on ^! cl9ical results4' ,x is4 ,8 po9t 0 well tak5 & x is a pr(\nd pity t ,pr(essor ,c>lson did n obs]ve 8 own rul+4 8,9 ! words ( a correspond5t ( ,! ,j\rnal ( ! ,am]ican ,m$ical ,association1 9 discuss+ ,pr(essor ,c>lson's criticism ( ,dr4 ,crile's #8,k9etic ,drive1' #8x behooves ! laboratory man to be circumspect 9 8 criticism ( cl9ical !ories1 s9ce go+ beyond ! b\nds ( well-e/abli%$ ?+s weak5s 8 position1 n m]ely ) ref]5ce to ! p>ticul> subject "u discussion1 b ) ref]5ce to cl9ical ph5om5a 9 g5]al4' ,cl9ical results h def9itely e/abli%$ ! value ( ,secretog54 ,z ! matt] n[ /&s ?is /atem5t is beyond criticism4 8,:5 ,secretog5 0 fir/ introduc$ we assum$ t x dep5d$ on secret9 = results produc$4 ,9 ?is assumption we 7 9 good company1 z witness$ by ! te/imony ( ,moore1 ,edie & ,abram :51 9 ! c\rse ( _! inve/igations z to ! value 9 diabetes ( a secret9-be>+ extract giv5 by m\?1#ajf !y said3 #8,9 ! majority ( ^! cases 444 !re has be5 no appreciable fall 9 ! output ( sug> 444 9 "s ( ^! negative cases !re has be5 not$1 h[ev]1 improvem5t 9 ! dige/ion &1 9 c]ta9 cases1 ! pati5t's weight has increas$4' ,!y also /ate t ! secret9-be>+ product #8appe>s to /imulate ! functional activity ( ! duod5um4'#ajf ,!y give a mo/ significant report4#ajg ,we quote f ! pap] z foll[s3 #ajf ,all italics are ours4 ,g4 ,w4 ,c>nrick ,company4 #ajg ,bio-,*em4 ,j\r4 #a3bh1 #aijf4 8#8,! pati5t _h be5 "u obs]vation = six mon?s be=e treatm5t & ! sug> 0 n r$ucible by diet4 ,almo/ at once ! dyspepsia f :i* he 0 suff]+ 0 reliev$ & 8 g5]al nutrition improv$ to su* an ext5t t he rega9$ ov] eighte5 p\nds 9 weight1 :i* he _h previ\sly lo/1 & ?is improvem5t 0 accompani$ by complete recov]y ( 8 physical & m5tal en]gies4'#ajf 8,inasmu* z ?is improvem5t c\ld n h be5 due to ! conta9$ secret9 x mu/ h be5 due to "s o!r pr9ciple conta9$ 9 ! extract4 ,our exp]i5ce & t ( ! physicians :o h us$ ,secretog5 e/abli% ! fact t ,moore1 ,edie & ,abram made no mi/ake :5 !y came to ! conclusion t :at !y t]m$ a secret9-be>+ extract /imulates ! functional activity ( ! duod5um & improves ! dige/ion4 8,:5 ,pr(essor ,c>lson 0 inve/igat+ ,secretog5 he mu/ h realiz$ t he 0 deal+ ess5tially ) an extract ( ! duod5al mucosa4 ,x is1 !re=e1 all ! m surpris+1 consid]+ 8 ext5sive rese>*es into ! lit]ature1 t he %\ld h ignor$ ! te/imony ( "s ( 8 own au?orities1 p>ticul>ly ,hallion1 z to ! value ( extracts ( ! duod5al mucosa 9 duod5al insuffici5cies4 ,! meticul\s c>efulness ) :i* ?is evid5ce 0 avoid$ is h>dly wor?y ( ! be/ traditions ( physiology1 a sci5ce :i* has tru? = its fir/ & la/ aim4 8,hallion 9 8 #8,la ,pratique de l',opo?rapie' says t ! #8aims ( duod5al opo!rapy are3 #a1 ,to supply defici5t duod5al juice4 #b1 ,above all to /imulate & to relieve ?is organ--notably to aid ! production ( secret9#d--;& s pr(it by ! /imulat+ action :i* duod5al extract ex]cises on ! duod5al mucosa :i* action we1 ,enriquez & myself1 believe & h exp]im5tally prov$1 con=ms to ! g5]al pr9ciples ( opo!rapy4 #c1 ,by means ( ! production ( secret91 to re9=ce ! bili>y1 pancreatic & inte/9al secretions4 #d1 ,to /imulate inte/9al p]i/alsis4 8#8,pr9cipal indications3 ,inte/9al dyspepsias1 inte/9al auto9toxications1 c]ta9 =ms ( con/ipation & duod5al insuffici5cy4' 8,at ! ,int]national ,congress ( ,m$ic9e1 ,madrid1 #aijc1 ,hallion said t he felt ju/ifi$ 9 /at+ t duod5al opo!rapy correctly c>ri$ out mu/ be class$ "u ! v be/ me?ods ( treat+ dyspepsia4#ajf ,! results _h be5 satisfactory &1 9 _m cases1 rem>kable4 ,x _h be5 nil 9 a few cases b x _h nev] be5 h>mful 9 any degree4 ,he po9t$ out t ,m>fan 0 ! fir/ to employ ?is sub/ance cl9ically4 ,m>fan _h _h p>ticul>ly excell5t results 9 *ildr5 ( #ae mon?s to #d ye>s suff]+ ) m>k$ malnutrition1 anorexia & con/ipation4 ,m>fan prescrib$ ! duod5al extract giv5 9 milk4#ajf ,hallion fur!r rem>ks t1 z he is n a practition]1 he _h _h only "o opportunity to te/ duod5al opo!rapy cl9ically4 ,! case 0 t ( a man ( #bf ye>s ) ob/9ate inte/9al dyspepsia & sev]e con/ipation :i* _h p]si/$ f *ildhood4 ,?is pati5t _h be5 treat$ by enemas1 laxatives1 diet1 etc4 ,treatm5t ) duod5al extract result$ 9 a complete cure4#ajf ,hallion po9ts out t ! mo/ satisfactory aspect ( duod5al opo!rapy is ! p]man5t effect produc$1#ajf :i* be>s out 8 /atem5t t ^! extracts h ! p[] to aid 9 ! re/oration ( function & /ructure ( an organ4 8,?is has be5 s well e/abli%$ t ! pr9ciple is n[ embodi$ 9 a law :i* is frequ5tly ref]r$ to z #8,hallion's ,law'3 #8,extracts ( an organ ex]t on ! same organ an excit+ influ5ce :i* la/s = a long] or %ort] "t4 ,:5 ! organ is insuffici5t x is conceivable t ?is influ5ce augm5ts its action &1 :5 x is injur$1 t x favors its re/oration4' 8,9 #8,la ,pratique de l',opo?rapie' ,hallion po9ts out t #8! opo!rapeutic product :i* corresponds to ! affect$ organ repres5ts 9 "s way ! /imulat+ & elective food = t organ1 & if we supply ! organ ) a food :i* is m complete ?an x necess>ily ne$s1 ! affect$ organ c ex]cise its elective action & take up only ^? sub/ances ( :i* x is 9 ne$4' 8,hallion's obs]vations on ?is po9t are beautifully borne out by ! classic "w ( ,j4 ,w4 ,drap]1 z report$ 9 ,! ,j\rnal ( ! ,am]ican ,m$ical ,association1 ,sept4 #bf1 #aiad4 ,?is report gives results 9 bo? laboratory & cl9ical exp]im5ts4 8,9 ord] to %[ t f$ jejunal & ileac epi!lium ex]cise "s special detoxicat+ p[]1 n yet und]/ood b def9itely recognizable1 ,drap] f$ a control s]ies ( dogs ) inte/9al ob/ruction1 exp]im5tally produc$1 on emulsifi$ cells ( liv]1 sple51 pancreas & muscle tissue4 ,^! animals liv$ a few h\rs long] ?an n-f$ controls1 b ,drap] says t x is evid5t t ^! cells _h ei!r no detoxicat+ action1 or a v feeble "o comp>$ ) inte/9al epi!lium4 ,he us$ jejunal & ileac epi!lium cl9ically 9 two in/ances3 #a/1 ,9 a female dog :i* _h _h #8*ronic /oma* tr\ble' = six mon?s4 ,:5 ,drap] saw h] %e _h _h complete inte/9al ob/ruction = five days1 ) symptoms ( ta*yc>dia1 extreme n]v\sness & great weakness 9 ! h9d legs4 ,drap] remov$ a pebble f h] inte/9e b h] condition 0 /ill grave4 8,%e 0 imm$iately put on small-inte/9e epi!lium d]iv$ f two dogs ( diff]5t bre$4 ,drap] says t f a long exp]i5ce ) duod5ally ob/ruct$ dogs1 he %\ld n h expect$ h] to recov]1 b ! symptoms gradually subsid$ & %e liv$4 ,! second in/ance 9 :i* he us$ ! epi!lium !rapeutically 0 9 ! case ( a man :o suff]$ f an annul> canc] ( ! inte/9e ) def9ite symptoms ( ob/ruction4 ,aft] ! op]ation1 & realiz+ t ! pati5t 0 9 a desp]ate condition1 he f$ him an emulsion ( inte/9al epi!lium f a dog4 ,! pulse improv$ & ! pati5t liv$4 8,"s ( ,drap]'s conclusions are z foll[s3 8#8,autotoxemia 9 inte/9al ob/ruction und\bt$ly arises f an int]f]5ce ) cellul> reactions ( ! inte/9al epi!lium4444 ,:5 small-inte/9e epi!lial cells ( heal?y animals are plac$ 9 ! /oma*#ajf ( duod5ally ob/ruct$ animals1 su* animals h liv$ ne>ly twice z long z n-f$ controll$ animals4 ,?is evid5ce is /rongly oppos$ to ! bact]ial !ory ( orig9 ( tox9s4' 8,! po9t to be emphasiz$ is ?is3 ,if ?is emulsion ( inte/9al epi!lium _h be5 f$ to a normal dog & a normal man1 :at w\ld h happ5$8 ,absolutely no?+4 ,on ! o!r h&1 giv5 z x 0 to a dog & a man 9 desp]ate ne$ x ex]cis$ a pot5t effect4 8,abundant cl9ical te/imony c be cit$ 9 support ( ! op9ions ( ,moore1 ,edie & ,abram1 ,hallion1 ,m>fan & ,drap] z to ! value ( extracts ( ! inte/9al mucosa giv5 by m\? 9 pa?ological conditions4 ,we h previ\sly cit$ ! publi%$ favorable op9ions ( su* ga/ro5t]ologi/s z ,an?ony ,bassl]1 ,lewis ,br9ton1 ,g4 ,r4 ,lockwood1 & ,r4 ,c4 ,kemp1 s !re is no ne$ to recapitulate _! exp]i5ces ) :at !y hone/ly believ$ to be secret9-be>+ extracts1 b :i* 7 ess5tially extracts ( ! duod5al mucosa4 8,supplem5t+ ! evid5ce ( ^! m5 z to ! value ( ^! extracts we submit an exc]pt f a lett] f "o ( ! be/ kn[n physicians ( ,ed9burgh3 8#8,i c speak 9 v high praise ( ,secretog51 :i* ,i h us$ 9 bo? tablet =m & z ! elixir4 ,!re is no d\bt ab\t its value 9 a c]ta9 class ( intractable indige/ion :i* refuses to be b5efit$ by any o!r rem$y4 ,on sev]al occasions ,i h be5 mu* gratifi$ by ! def9ite relief obta9$ 9 ?is class ( cases4 ,x hits ! m>k also 9 "s types ( ob/9ate con/ipation--,i ?9k ^? cases :]e ! tr\ble is wrapp$ up 9 impair$ en]vation ( ! inte/9e1 & :]e /asis occurs at c]ta9 segm5ts ( ! canal4' 8,hallion v p]t95tly po9ts out#ajh t x is n[ accept$ t opo!rapy is n sub/itutive1 b homo/imulative & he rem>ks fur!r t x is well to be> 9 m9d t ! s-call$ active sub/ances :i* make ! extract efficaci\s ne$ n necess>ily be ! hormones4 #8,x may be ! elem5ts ( tissue /ructure :i* may come to ! aid ( ! injur$ organ4 ,! hormone %\ld n !re=e be look$ on z ! only active ag5t ( opo!rapy &1 :ile its action is important1 x ne$ n necess>ily be prepond]ant4 ,! *emical isolation ( ! hormones is1 ( c\rse1 ( int]e/ b may n be z vital to organo!rapy z we h ?\ght4' 4440 #ajh ,presse ,mdicale1 #aiab1 p4 #dcc4 ,,comm5t ,,by ,,! ,,c\ncil ,,on ,,ph>macy ,,& ,,*emi/ry ,! ,g4 ,w4 ,c>nrick ,company1 :i* =m]ly claim$ t ,secretog5 0 efficaci\s because x conta9$ secret91 n[ admits ?is claim to be unf\nd$4 ,not)/&+1 ! manufactur]s /ill call _! product ,secretog5 & make = x practically ! same !rapeutic claims z be=e4 ,!y n[ base ^! claims on vague 8pr9ciples ( opo!rapy0 & on s-call$ 8cl9ical te/imony40 ,! burd5 ( pro( re/s on !m to %[ t ^! old claims1 already discr$it$ b put =? aga9 on new gr\nds1 are ju/ifi$4 ,h !y done s8 ,! 8cl9ical te /imony0 is n conv9c+4 ,s mu* ( x z is def9ite en\gh to p]mit ( criticism has already be5 dealt )4 ,! rema9d] consi/s ( m]e ass]tions2 x is n ?r\gh reliance on su* evid5ce t ! ,c\ncil c dis*>ge its tru/4 ,on ?is side ( ! "q !re is no?+ new to be said--reass]tion ( a refut$ argum5t does n con/itute fre% pro(4 ,nor is ! case bett] on ! exp]im5tal side4 ,! /atem5ts ( ,hallion1 ,enriquez1 ,zuelz] & o!rs#aji z to ! exi/5ce ( a 8p]i/altic hormone0 n only h fail$ ( confirmation1 b also h be5 positively discr$it$4 ,) reg>d to ,drap]'s "w1 :i* dealt ) acute inte/9al ob/ruction1 x is difficult to see :at is its relevance to ! pres5t issue1 p>ticul>ly s9ce ,drap]'s results 7 obta9$ ) a product d]iv$ f ! mucosa ( ! jejunum & ileum & n ) an extract ( ! duod5um su* z ,secretog5 purports to be4 #aji ,cf4 int]al4 ,s*ag9dweit1 ,e43 ,exp]im5telle ,v]su*e mit ,hormonal1 ,ar*4 ,int]nat4 de ,ph>macod41 #aiac1 p4 #gg4 ,! innu5do t ! ,c\ncil discrim9ates 9 favor ( c]ta9 manufactur]s1 is itself a confession ( weakness4 ,9 publi%+ ?is correspond5ce ! ,c\ncil's sole object is to put ! m$ical pr(ession 9 possession ( ! exact facts ( ! case4 ,^! may fairly be summ$ up z foll[s3 #a4 ,secretog5 0 orig9ally m>ket$ z a prep>ation conta9+ secret94 ,none 0 f\nd 9 x4 #b4 ,not)/&+ pro( ( ?is fact1 ! ,g4 ,w4 ,c>nrick ,company reta9 ! orig9al "n ( ! product1 kn[+ t1 by its association ) _! =m] errone\s ass]tions conc]n+ ,secretog51 ?is "n mu/ inevitably convey to a physician us+ ! product ! impression t he is adm9i/]+ secret94 ,9 ! adv]tis+ lit]ature no h9t is giv5 t ?is orig9al /atem5t 0 errone\s4 #c4 ,! product call$ 8,secretog50 has n be5 %[n1 ei!r exp]im5tally & by s\nd cl9ical evid5ce1 to possess useful !rapeutic prop]ties4 ,"u ^! circum/ances ! ,c\ncil reaffirms its decision4--7,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiaf1 p4 #gb47 ,,iron ,,citrate ,,gre5 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,h4 ,k4 ,mul=d ,company & ,e4 ,r4 ,squibb & ,sons submitt$ to ! ,c\ncil ampules conta9+ solutions ( iron citrate gre54 ,x ?us became necess>y to consid] ! eligibility ( iron citrate gre5 itself = admission to ,new & ,non(ficial ,rem$ies4 ,z ! rules ( ! ,c\ncil provide t noness5tial modifications ( (ficial or nonpropriet>y prep>ations w n be recogniz$1 ! above nam$ firms 7 ask$ to /ate :at advantages1 if any1 ! s-call$ iron citrate gre5 _h ov] ! (ficial iron & ammonium citrate4 ,9 reply ! ,h4 ,k4 ,mul=d ,company wrote t x _h come to ! conclusion t iron citrate gre5 & ampules !re( w\ld und\bt$ly be consid]$ by ! ,c\ncil z a noness5tial modification ( an (ficial product1 add+3 8,x seems to diff] f ! (ficial f]ric citrate s f> z ess5tials g only 9 color1 b cu/om1 :i* is exce$+ly h>d to *ange 9 ,s\? ,am]ica1 dem&s t ?is gre5 v>iety ( ampules be us$ 9 place ( ! (ficial product40 ,9 reply to a simil> lett] ( inquiry ,e4 ,r4 ,squibb & ,sons wrote3 8,iron citrate gre5 7iron & ammonium citrate gre57 diff]s f ! ,u4 ,s4 ,p4 iron & ammonium citrate 9 t x conta9s less iron & m citric acid & m ammonium citrate ?an does ! latt]4 ,x is ( c\rse a modification ( ! (ficial salt & is suppli$ to meet a real dem&4 ,its reaction is q decid$ly acid & our pres5t /ock conta9s ,fe slightly bel[ ! ,u4 ,s4 ,p4 requirem5ts = iron1 assay+ #ae4gd p] c5t4 in/ead ( #af p] c5t4 ,fe4 ,! te/s us$ to control its quality are ^? = ! (ficial product except z be=e indicat$1 x is always acid in/ead ( neutral1 z ! ,u4 ,s4 ,p4 requires = t salt40 ,! small] iron cont5t 7#ih p] c5t4 ( ! ,u4 ,s4 ,p4 requirem5t7 ( ! gre5 v>iety ref]r$ to by ,e4 ,r4 ,squibb & ,sons is s small z to be negligible4 ,fur!r1 ! l[ iron cont5t z well z ! acidity ( ! gre5 salt w\ld appe> to be detrim5ts r ?an advantages4 ,inasmu* z no evid5ce has be5 pres5t$ to %[ t iron citrate gre5 is sup]ior 9 any way to ! well-kn[n iron & ammonium citrate ! ,c\ncil held t iron citrate gre51 & ) x ! dosage =ms1 0 ineligible to ,n4 ,n4 ,r4 ,! prec$+ report 0 submitt$ to ! ,mul=d ,company & to ,e4 ,r4 ,squibb & ,sons = comm5t be=e publication4 ,! =m] firm repli$ t 9 ! pres5t case x felt b\nd to supply ! exi/+ dem&1 ! latt] repli$ t1 to give ! ,c\ncil its support 9 ?is matt]1 ! sale ( iron citrate gre5 & ampules !re( w\ld be discont9u$4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #ac1 #aiag47 ,,aspir9 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ref]ee's report on ,aspir9-,bay] :i* foll[s 0 submitt$ to ! ,c\ncil & adopt$ by x &1 9 accordance ) ! ref]ee's recomm5dation1 0 s5t to ! ,bay] ,company1 ,inc4 ,! company's reply conta9$ no?+ to w>rant ! cont9u$ recognition ( ?is product by ! ,c\ncil4 ,x 0 accord+ly direct$ t ,aspir9-,bay] be omitt$ f ,new & ,non(ficial ,rem$ies4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,,ref]ee',s ,,report ,! ref]ee's att5tion has be5 call$ to ! sy/ematic campaign ( adv]tis+ aspir9 to ! public4 ,he is in=m$ t tablets h be5 m>ket$ = "s "t 9 8ve/-pocket0 boxes1 be>+ ! "n 8,aspir90 p]man5tly affix$1 :i* is 9 te*nical conflict ) ! ,c\ncil's rule aga9/ indirect adv]tis+ to ! public4 ,m rec5tly1 conspicu\s adv]tisem5ts h appe>$ 9 daily pap]s4 ,^! are te*nically 9 conflict ) ! rule aga9/ direct adv]tis+ to ! public4 ,9 addition to ! pla9 te*nical conflicts ) ! ,c\ncil's rules !re is a feature ( ! case :i* has n hi!rto be5 rais$ & :i* %\ld be fully consid]$3 ,x may be rem>k$ t ! adv]tisem5ts conta9 no !rapeutic recomm5dation1 & d n1 on _! face1 urge ! public to employ aspir9 b app>5tly m]ely tell ! public h[ x may protect itself aga9/ sophi/ication4 ,9 sub/ance1 !y say3 8,if y are a us] ( aspir91 ?is is h[ y may obta9 ! g5u9e40 ,x might be said t ?is is n an attempt to increase ! use or sale ( aspir9--! ord9>y object ( adv]tis+--b t ! means ( protection aga9/ adult]ation is a 8subject on :i* ! public %\ld be in/ruct$40 ,! pr9ciple ( su* exceptions is /at$ 9 ! comm5ts to ,rule #c 7,new & ,non(ficial ,rem$ies1 #aiaf1 p4 #ae72 & al?\gh ! pres5t case does n come "u ! exceptions specifi$ "u ^! comm5ts1 x may be urg$ t ! exceptions ne$ to be increas$ z occasion arises4 ,! notori\s adult]ation ( aspir9 may well be urg$ z e/abli%+ a ne$ = a simil> exception 9 its use4 ,! g5]al pr9ciple ( protect+ ! public aga9/ fraud1 adult]ation & sub/itution is directly 9 l9e ) ! objects ( ! ,c\ncil1 & des]ves comm5dation & support4 ,x is obvi\s1 h[ev]1 t ! means adopt$ = ?is end mu/ be effici5t1 t !y mu/ n op5 ! door to o!r1 p]haps great] evils & t !y mu/ be us$ 9 good fai?4 ,! policy ( adv]tis+ 8,aspir9-,bay]0 mu/ be exam9$ 9 ^! respects4 ,9 ! fir/ place1 ! acceptance ( a product by ! ,c\ncil implies an agreem5t by ! manufactur]s or ag5ts t !y w adh]e /rictly to ! ,c\ncil's rules & w n dep>t f ! lett] or _s ( ^! rules )\t notice to ! ,c\ncil4 ,?is pr9ciple has be5 grossly infr+$ 9 ! pres5t case4 ,!re c be no d\bt t ! ag5ts 7 aw>e t _! adv]tisem5ts conflict$1 at lea/ ) ! lett] ( ,rule #c4 ,nev]!less1 !y did n1 9 any way1 in=m ! ,c\ncil ( ! *ange 9 policy4 ,9 ?is respect1 at lea/1 !y h n act$ 9 good fai?4 ,secondly1 ! word+ ( ! adv]tisem5t implies t only ! tablets /amp$ ) 8,! ,bay] ,cross0 are g5u9e4 ,?is is mislead+1 s9ce e druggi/ has ! "r to make un/amp$ tablets ( aspir91 fully z g5u9e z ^? /amp$ ) ! cross4 ,?irdly1 ! cross itself _c be consid]$ an effici5t protection2 = p :o imitate aspir9 w n hesitate to imitate ! /amp4 ,! rem$y1 9 ei!r case1 & z ) any o!r drug1 is ! exam9ation ( trade samples1 & ! vigor\s prosecution ( ^? guilty ( violat+ ! law4 ,f\r?ly1 ! p]man5t affix+ ( ! "n 8,aspir90 to ! ve/-pocket boxes is also ineffici5t z a protection1 & s]ves ma9ly z an adv]tisem5t4 ,fif?ly1 :atev] may h be5 ! motives ( ! adv]tis]s1 & h[ev] c>efully ! adv]tisem5ts are word$1 !y w inevitably t5d to increase ! use ( aspir9 by ! public1 & ?is is directly aga9/ ! int]e/s ( public heal?4 ,! public does n "k1 z physicians d1 t heada*es are m]ely symptoms ( o!r1 sometimes v s]i\s conditions2 & t !y are (t5 ! signal = ! ne$ ( a ?or\gh physical exam9ation & diagnosis4 ,x is true t !y are (t5 also ! symptoms ( v m9or d]angem5ts1 :i* w "r !mselves spontane\sly2 & t1 9 su* cases1 drugs l aspir9 may give relief & may d no h>m4 ,! pati5t1 h[ev]1 is n educat$ to di/+ui% "o class f ! o!r1 & !re=e any?+ t t5ds to promote ! indiscrim9ate use ( su* rem$ies z aspir9 is detrim5tal to ! public heal?4 ,fur!rmore1 aspir9 itself is n always h>mless4 ,al>m+ idiosyncrasies are suffici5tly common t ! use ( ! fir/ doses1 at lea/1 %\ld require m$ical sup]vision4 ,) ^! consid]ations 9 m9d1 ! ref]ee is ( ! op9ion t ! direct & indirect adv]tis+ ( aspir9 is to be condemn$4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #bj1 #aiag47 ,,pil4 ,,casc>a ,,comp\nd-,,rob9s ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,a circul> issu$ by ! ,a4 ,h4 ,rob9s ,company ( ,ri*mond1 ,va41 conta9s ! foll[+ /atem5t3 8,,pil4 ,,casc>a ,,comp\nd-,,rob9s is a rational !rapeutic =mula1 compos$ ( ,,casc>a1 ,,podophyll91 ,,colocyn? & ,,hyoscyamus1 :i* promotes a natural fl[ ( secretions1 :i* is1 9 turn1 ! physiologic /imulant ( p]i/alsis4 ,?us1 a normal evacuation is produc$ )\t subsequ5t inhibition4 8,!y conta9 no ,m]cury1 ,/ry*nia nor ,belladonna4 8,an ideal aid to any rem$ial ag5t1 :5 a ,mild1 ,m$ium or ,/rong alim5t>y /imulant is ne$$ sic4 8,made 9 two /r5g?s1 ! dosage may be easily regulat$ s z to obta9 ! effects ( an ,anti-,dyspeptic1 ,ap]i5t1 ,laxative or ,ca?>tic1 z desir$4 ,!y nev] cause discom=t unless giv5 9 l>g] dose ?an ne$$40 ,?is prep>ation is ano!r example ( ! innum]able mixtures ( well-kn[n drugs hav+ no?+ 9 ! way ( orig9ality or ( special !rapeutic value to recomm5d !m4 ,! adv]tis+ implies t ?is p>ticul> comb9ation has a special action on ! secretions ( ! ga/ro-inte/9al tract2 o!rwise x w\ld be h>d to expla9 ! claim t ! prep>ation is antidyspeptic1 if t means any?+ m ?an a laxative or ca?>tic4 ,! claim is made t ?is prep>ation conta9s no belladonna--yet x admitt$ly conta9s hyoscyamus6 ,?is manife/s ei!r ignorance on ! "p ( ! manufactur]s1 or an ef=t to impose on ! m$ical pr(ession4 ,bo? belladonna & hyoscyamus conta9 v>iable am\nts ( simil> alkaloids1 *iefly hyoscyam94 ,hyoscyamus is feebl] ?an belladonna 9 its action1 z x conta9s less alkaloid4 ,! qualitative diff]5ces betwe5 ! two drugs1 ) ref]5ce to _! use z laxatives1 is s slight z to make ! company's claim = hyoscyamus appe> ei!r delib]ately mislead+ or to be ! result ( crass ignorance4 ,promot+ ?is mixture ( well-kn[n laxatives & ca?>tics z an 8ideal aid to any rem$ial ag5t :5 a mild1 m$ium or /rong alim5t>y /imulant is ne$$0 is a slur on ! intellig5ce ( physicians4 ,pil4 ,casc>a ,comp\nd-,rob9s is n acceptable = ,new & ,non(ficial ,rem$ies4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #bg1 #aiag47 ,,ca/a-,,flora ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,ca/a-,flora is "o ( ^? complex prep>ations :i* are (f]$ to ! m$ical pr(ession1 ) plausible argum5ts 9 support ( ! claims made4 ,x is put out by ! ,wm4 ,s4 ,m]rell ,*emical ,co41 ,c9c9nati4 ,ea* fluid\nce is said to repres5t3 8,ca/anea1 fre% leaves1 #dj gr42 ,passiflora1 fre% plant1 #dj gr42 ,gelsemium1 gre5 t9cture1 #h m9ims2 ,inula1 repres5t$ by ! camphorace\s /e>opt5e ,hel591 #bj grs42 ,iodiz$ ,lime1 #h grs42 ,m5?ol1 #a-d grs42 ,aromatic ,syrup ,y]ba ,santa1 #fj m9ims40 ,x is said to be3 8,a new comb9ation ( well-tri$ rem$ies ( especial value 9 p]tussis & o!r spasmodic c\ghs4 ,x is compos$ ( a/r+5t1 antispasmodic1 s$ative & expectorant ag5ts1 t control ! p>oxysms1 relieve ! irritation1 promote expectoration1 & give tone to muc\s membranes involv$40 ,/ill m exagg]at$ claims are made = ! individual con/itu5ts ( ,ca/a-,flora1 p>tly by direct /atem5t1 p>tly by inf]5ce4 ,= example3 8,ca/anea is almo/ a specific 9 :oop+ c\gh & o!r spasmodic c\ghs4 8,passiflora is a n>cotic1 s$ative & antispasmodic )\t habit-=m+ prop]ties1 nor does x lock up ! secretions & upset dige/ion l opiates4 8,inula 7elecampane7 has be5 employ$ z a c\gh rem$y 9 ,engl& = c5turies4 ,its action is simil> to guaiacol & creosote4 ,its active pr9ciple1 hel591 is de/ructive ( tub]cle bacilli 9 dilutions ( #a to #aj1jjj4 8,iodiz$ ,lime1 ,m5?ol1 & ,y]ba ,santa are too well kn[n z expectorants & antiseptics to require m ?an pass+ m5tion40 ,t ,ca/a-,flora is a 8new0 comb9ation may be admitt$2 x is improbable t exactly ?is comb9ation ( obsolete drugs 0 ev] be=e select$ = any purpose :atev]1 b ! /atem5t is mislead+ 9 t no new pr9ciple ( !rapeutics is involv$4 ,on ! contr>y1 ! comb9ation is j :at might be expect$ f haphaz>d *oos+ ( disc>d$ & ne>ly =gott5 drugs4 ,x seems incr$ible t a reputable firm ( manufactur+ ph>maci/s w\ld make ! positive /atem5t t ca/anea is almo/ a specific 9 :oop+ c\gh4 ,:y n say x is a specific8 ,x w\ld be ab\t z true4 ,a specific or 8almo/ specific0 = ?is disease w\ld rank among great m$ical discov]ies2 b ca/anea is m]ely a slightly a/r+5t drug nei!r bett] nor worse ?an scores ( o!r a/r+5t drugs t h be5 tri$1 f\nd valueless & disc>d$4 ,h>dly less surpris+ are ! /atem5ts reg>d+ passiflora4 ,?is h]b has be5 on ! m>ket ab\t ?ree qu>t]s ( a c5tury4 ,n only has x nev] e/abli%$ itself 9 sci5tific m$ic9e1 b x is n ev5 m5tion$ 9 mod]n /&>d works on !rapeutics4 ,( all ! /atem5ts made 9 ! circul> p]haps ! mo/ rem>kable1 9 t x is s dang]\sly mislead+1 is t reg>d+ hel591 ! active pr9ciple ( elecampane4 ,! /atem5t t ?is pr9ciple 7hel597 is de/ructive ( tub]cle bacilli 9 dilutions ( #a-aj1jjj c only mean t x is ( extraord9>y value 9 ! treatm5t ( tub]culosis2 9 fact1 x is def9itely /at$ t ! action ( elecampane is simil> to t ( guaiacol & creosote4 ,x is obvi\s t any drug :i* w\ld de/roy ! tub]cle bacilli 9 ! human lungs )\t ex]t+ a toxic action on ! pati5t w\ld be a great contribution to m$ic9e4 ,b al?\gh elecampane may h be5 us$ = c5turies x has prov$ to h little1 if any1 m]it1 & ev5 ! ,national ,/&>d ,disp5satory1 p4 #hdh1 says3 8,elecampane 0 =m]ly employ$ z a tonic1 /imulant1 diuretic1 diaphoretic1 expectorant1 & emm5agogue1 b has n[ l>gely fall5 into disuse40 ,"o looks 9 va9 9 ! /&>d textbooks on !rapeutics = a description ( ! uses ( inula 7or elecampane71 & ( its s-call$ 8active pr9ciple10 hel594 ,! circul> to :i* ref]5ce has be5 made says1 ref]r+ to ! use ( ca/anea & passiflora 9 ! treatm5t ( :oop+ c\gh3 8,gelsemium1 :5 made f ! fre%1 gre5 plant--z is ,m]rell's--is an excell5t adjuvant to ! above drugs1 & allays ! n]v\s irritability s frequ5tly pres5t40 ,h4 ,c4 ,wood1 ,jr4 7,ph>macology & ,!rapeutics1 #aiaf1 p4 #afj71 says ( gelsemium3 8,gelsemium 0 orig9ally employ$ z an art]ial s$ative & febrifuge 9 ! mal>ial fev]s ( ! ,s\?1 & subsequ5tly 9 /h5ic fev]s4 ,x appe>s 9 "s way to depress ! bodily temp]ature1 b x does n appe> probable t any advantage to be d]iv$ f x w c\nt]balance ! dang] att5d+ its employm5t 9 ! l>ge doses requir$4 ,9 a/hma1 spasmodic l>yngitis1 :oop+ c\gh1 & n]v\s c\gh x has be5 recomm5d$ by ,b>?ol[1 b is little us$40 ,t is ab\t z favorable a /atem5t = ! drug z is to be f\nd 9 ! textbooks1 & x s]ves to illu/rate h[ little new !re is 9 ?is mixture ( obsolete drugs t ,m]rell seeks to m>ket z "o possess+ extraord9>y !rapeutic value4 ,ev5 ?\gh ! +r$i5ts1 or c]ta9 ( !m1 7 s+ly useful 9 ! treatm5t ( ^? conditions = :i* ,ca/a-,flora is recomm5d$1 no "o c\ld possibly =esee ! effect 9 any giv5 case ( su* a jumble ( drugs1 bo? active & in]t1 z is said to be repres5t$ 9 ?is prep>ation4 ,! prescrib+ ( su* mixtures1 ! action ( :i* _c 9 any way be =ese51 is pla9 *>latanism4 ,9 addition1 ! v>i\s drugs 9 ,ca/a-,flora are pres5t 9 su* proportions t ! dose ( ea* ( ! sev]al +r$i5ts be>s no relation to ! commonly accept$ dose4 ,ca/a-,flora is n acceptable = ,new & ,non(ficial ,rem$ies4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #bg1 #aiag47 ,,firwe9 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,firwe9 is a product ( ,! ,tild5 ,company1 ,new ,lebanon1 ,n4 ,y4 ,x is sold "u ! claim t :5 swall[$ x has a 8pr$ilection0 bo? = ! bron*ial mucosa & also = ! g5ito-ur9>y organs4 ,to quote3 8,expectorant1 ,s$ative1 ,antispasmodic 9 ! ,treatm5t ( ,inflammations ( ! ,bron*ial & ,g5ito-,ur9>y ,mucos40 8,firwe9 be+ a bl&1 soo?+ balsam possesses a wide range ( adaptability & increas$ pot5cy because ( its heal+ virtues & usefulness z an expectorant1 s$ative & antispasmodic 9 bron*itis1 & inflammation & cat>rh ( nose1 ?roat & lungs40 8,firwe9 has a special pr$ilection = mucos1 ?is be+ z m>k$ 9 diseases ( ! g5ito-ur9>y sy/em z x is 9 ! respiratory organs4 ,9 inflammatory diseases ( ! g5ito-ur9>y organs1 its bl&1 curative prop]ties are ex]t$ 9 a gratify+ degree4 ,9 cy/itis & uritis x is cle>ly indicat$44440 ,little in=mation is giv5 conc]n+ ! composition ( ,firwe94 ,an old circul> says3 8,firwe9 conta9s ,phosphorus1 ,iod9 & ,brom9 f9ely bl5d$ ) a balsame\s elixir made f ! fir tree40 ,f a m rec5t circul> we quote3 8,firwe9 is prep>$ f ! inside fre% gre5 b>k ( ! fir tree 4440 ,! label on ! product reads3 8,firwe9 is pleasantly & effectively bl5d$ ) salts ( iod9 & brom91 held 9 solution ) #bj p] c5t4 alcohol40 ,! !rapeutic claims made = ,firwe9 & ! my/]y en%r\d+ its composition make x obvi\s t ! product is int5d$ to appeal to ^? :o are ei!r ?\ghtless or ignorant4 ,?is is emphasiz$ by ! sugge/ion t ,firwe9 be comb9$ ) 7#a7 cod liv] oil 7"u ! claim t x w 8promote ! effici5cy ( ! oil071 ) 7#b7 :isky = ! treatm5t ( bron*orrhea ( ! ag$1 & ) 7#c7 syrup ( hypophosphites = ! treatm5t ( p]si/5t bron*itis4 ,z ! composition ( ,firwe9 is secret1 ! !rapeutic claims unw>rant$1 & its use irrational1 ! ,c\ncil decl>$ x inadmissible to ,new & ,non(ficial ,rem$ies4--7,f ,j\rnal ,a4 ,m4 ,a41 ,feb4 #ag1 #aiag47 ,,firolyptol ,,pla9 ,,& ,,firolyptol ,,) ,,kreosote ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,firolyptol1 ano!r product ( ,! ,tild5 ,company1 is1 we are told1 compos$ ( eucalyptol #aj drops1 cottonse$ oil #a_/b ounce & ,firwe9 en\gh to make #a ounce4 ,z ! composition ( ,firwe9 is secret1 x is evid5t t ! composition ( ,firolyptol is also unkn[n1 except to ! manufactur]s4 8,firolyptol ) ,kreosote0 is said to conta91 9 addition to :atev] may be ! compon5t p>ts ( ,firolyptol1 #aj m9ims ( creosote to ea* ounce4 ,accord+ to an adv]tisem5t1 ,firolyptol ) ,kreosote is 8antitub]cul\s1 anti/rum\s0 & 8conta9s all ! desir$ features ( cod liv] oil & is readily assimilat$40 ,! adv]tisem5ts ( 8,firolyptol ,pla90 & 8,firolyptol ) ,kreosote0 seem to h = _! key-note ! ass]tion t cottonse$ oil is a p>ticul>ly valuable nutrim5t & t :5 comb9$ ) con/itu5ts ( ,firolyptol & ,firolyptol ) ,kreosote becomes p>ticul>ly valuable to ! tub]cul\s4 ,to quote f an adv]tis+ circul>3 8,n[ t ! recon/ructive prop]ties ( cottonse$ oil are bett] appreciat$ by ! pr(ession1 ! advantages t foll[ ! adm9i/ration ( a palatable emulsion ( ?is /r5g!n+ & fatt5+ food product are be+ demon/rat$ 9 hundr$s ( cases :]e =m]ly reliance w\ld h be5 plac$ 9 cod liv] oil4444 ,a rec5t writ] says t pure cottonse$ oil is ! greate/ & pure/ vegetable oil kn[n to *emi/ry1 & w d mu* t[>d revolutioniz+ ! treatm5t ( ! ,,great ,,:ite ,,plague4444 ,if ! treatm5t ( tub]culosis c\ld resolve itself into ! adm9i/ration ( a fatty sub/ance 9 a readily assimilat$ =m1 !re w\ld be no ne$ = any "p ( ,,firolyptol b ! ,cottonse$ ,oil4444 ,! toxic mat]ial con/antly produc$ 9 ! sy/em by ! g]ms ( tub]culosis t5d to expose x m & m to ! ravages ( ! disease1 & ! physiologic functions ( ! body suff] a con/ant depression4 ,to neutralize ?is g]m activity ) a consequ5t production ( tox9s x seems mo/ logical to employ su* ag5ts z h demon/rat$ _! suitability = su* purposes1 = :i* reason ,eucalyptol & ,kreosote ) ,firwe9 are incorporat$ 9 ,,firolyptol40 ,! ass]tion t cottonse$ oil is an especially valuable =m ( fat is )\t w>rant1 b ev5 if x 7 true ! fat is available 9 *eap & palatable =ms 9 num]\s o!r cottonse$ oil products4 ,x is unnecess>y to discuss ! problematic value ( creosote 9 ! treatm5t ( tub]culosis or ! value ( eucalyptol 7n[ g5]ally ab&on$71 or ev5 ( ! secret mixture ,firwe94 ,food & fre% air1 n drugs1 con/itute ! fundam5tals ( ! treatm5t ( tub]culosis1 & x is bo? irrational & detrim5tal to ! int]e/s ( ! tub]cul\s to adm9i/] v>i\s pot5t ag5ts 9 fix$ & unkn[n am\nts ) su* simple articles ( food z cottonse$ oil4 ,nei!r ( ^! products is acceptable = ,new & ,non(ficial ,rem$ies4 ,editorial ,note4--,firwe9#aaj has be5 adv]tis$ to physicians = tw5ty-five or ?irty ye>s & x is a sad comm5t>y on ! intellig5ce ( our pr(ession t a prep>ation sold "u su* obvi\sly false & mislead+1 n to say silly1 claims1 %\ld /ill be 9 exi/5ce4 ,firwe9 is claim$ to 8prev5t wa/e ( tissue0 9 tub]culosis4 ,if x _h ?is p[]1 x w\ld h f\nd its place long ago among ! few great ag5ts 9 drug !rapy4 ,z a matt] ( fact1 ,firwe9 has ga9$ virtually no recognition outside ( ! 8lit]ature0 ( ! ,tild5 conc]n4 ,! claims made = ,firwe9 are a peculi> mixture ( /udi$ c&or--:5 ! tru? is n likely to hurt its sale--& inane vapor+--:5 ! facts w\ld n r$\nd to its cr$it4 ,! ,tild5 ,company decl>es t 8,firwe9 /&s )\t a pe] 9 its class40 ,b ! company adds #aj drops ( eucalyptol & "s cottonse$ oil to ?is pe]less product & an improvem5t is born--8,firolyptol06 ,!n1 to p]fect ! already p]fectly p]fect$1 #aj drops ( creosote are add$ to 8,firolyptol0 & ! pr(ession is (f]$ 8,firolyptol ) ,kreosote06 ,9 j :at v]bal pyrote*nics ! ,tild5 ,company might indulge1 %\ld x decide to add t5 drops ( some?+ else to 8,firolyptol ) ,kreosote10 "o %udd]s to contemplate4 #aaj ,?ree o!r ,tild5 products h be5 ! subject ( des]v$ & unfavorable comm5t 9 ! ,j4 ,a4 ,m4 ,a3 8,n>k9e0 9 ! issue ( ,oct4 #bd1 #aijh1 8,hydrocyanate ( ,iron-,tild50 9 ! issue ( ,june #ai1 #aiji1 & 8,febrisol10 9 ! issue ( ,june #bi1 #aiab4 ,! fir/ two articles are repr9t$ 9 ! late/ 7#i?7 edition ( 8,! ,propag&a = ,re=m40 ,if we are accus$ ( exhibit+ undue levity 9 discuss+ a !rapeutic problem1 we c only answ] t x is impossible to consid] s]i\sly ! ,*>lie ,*apl9s ( ! no/rum _w4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,feb4 #ag1 #aiag47 ,,b9iodol ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,9 accordance ) ! usages ( ! ,c\ncil1 ! report :i* appe>s bel[ along ) ! reports ( ! cl9ical inve/igation by ,drs4 ,cole & ,keidel ^u :i* ! recomm5dations ( ! ref]ee 7 bas$ 7 s5t to ! manufactur] = comm5t4 ,! reply ( ! manufactur] conta9$ no evid5ce :i* ju/ifi$ ! ,c\ncil 9 modify+ ! action already tak54 ,publication ( ! report 0 !re=e au?oriz$4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,b9iodol 0 submitt$ to ! ,c\ncil by ! manufactur]1 ,*>les ,c4 ,y>br\gh1 ,memphis1 ,t5n4 ,! manufactur] claims ! product is a solution ( #a p] c5t4 ( r$ m]curic iodid & #b4ge p] c5t4 ( guaiacol 9 bl& vegetable oil4 ,x is m>ket$ ) ! implication t x is new & sup]ior to o!r oil solutions ( m]curic iodid4 ,= in/ance3 8444 x is a /raight solution ( ?is m]curial comp\nd1 z no alkal9e iodide or o!r *emical is us$ to br+ ab\t ! solution40 8444 ,x is probably ! fir/ & only "o-p]c5t oil solution ( /raight m]cury b9iodide made 9 ,am]ica44440 ,! manufactur]1 9 a lett] address$ to ! secret>y ( ! ,c\ncil1 expla9s3 8,by /raight solution1 ,i mean t ! solution ( ! r$ m]curic iodid is effect$ )\t ! aid ( any alkal9e iodid or o!r *emicals4444 ,b9iodol 0 fir/ (f]$ e>ly 9 #aiab 4440 8,b9iodol is1 !re=e1 sup]ior & mu* to be pref]r$ to o!r m]curials us$ = l purposes4 ,x is highly active !rapeutically1 produc+ ! desir$ effects1 usually )\t ! inevitable disadvantages ( o!r m]curials4 ,x r>ely causes salivation1 di>rhea1 or o!r symptoms ( m]curial intol]ance1 ev5 :5 pu%$ to full !rapeutic effect & :5 giv5 = a consid]able p]iod ( "t4 ,nor does x produce anemia40 ,! ,*emical ,laboratory ( ! ,am]ican ,m$ical ,association f\nd t ,b9iodol conta9$ #a p] c5t4 ( m]curic iodid & #b4e p] c5t4 ( guaiacol2 h5ce ! composition is ess5tially z claim$4 ,x is n true1 h[ev]1 t ,b9iodol is ! 8fir/ & only "o-p]c5t solution ( /raight m]cury b9iodide made 9 ,am]ica40 ,z %[n 9 ,! ,j\rnal ,a4 ,m4 ,a41 ,dec4 #i1 #aiad1 p4 #bbdg1 =mulas by ,lemaire & ,dunn+ = mak+ a 8/raight0 solution ( m]curic iodid 7 publi%$ 9 ?is c\ntry 9 #aiji & #aiaj1 respectively4 ,moreov]1 a #a p] c5t4 solution ( m]curic iodid 9 oil is on ! m>ket & is describ$ 9 ,new & ,non(ficial ,rem$ies4 ,to det]m9e :e!r or n ,b9iodol is 8sup]ior & mu* to be pref]r$ to o!r m]curials us$ = l purposes10 ! ,c\ncil secur$ ! coop]ation ( ! ,dep>tm5t ( ,d]matology & ,syphilology ( ! ,we/]n ,res]ve ,univ]sity coop]at+ ) ! ,clevel& ,city ,hospital1 & ( ! ,johns ,hopk9s ,hospital4 ,ea* receiv$ ?ree samples1 label$ respectively1 #a1 #b & #c3 #a conta9$ ,b9iodol2 #b1 a #a p] c5t4 solution ( m]curic iodid 9 oil2 #c1 a solution made up accord+ to ! =mula ( ,b9iodol1 namely1 #a p] c5t4 ( m]curic iodid & #b4e p] c5t4 ( guaiacol 9 oil4 ,all ! solutions 7 /]ile4 ,! inve/igators 7 n in=m$ :i* prep>ation 0 designat$ by ! respective numb]s1 b !y 7 ask$ to use ! prep>ations :5 intramuscul> injections ( a #a p] c5t4 oily solution ( m]curic iodid 7 indicat$1 & to note :at diff]5ces1 if any1 7 obs]v$ foll[+ ! use ( ! diff]5t solutions reg>d+ pa91 discom=t1 induration & any o!r evid5ces ( effects ( ! m$icam5ts4 ,! ,clevel& inve/igator reports t ! pati5ts 7 m or less confus$ 9 _! replies to inquiries & gave r indef9ite & conflict+ answ]s4 ,aft] c>efully tabulat+ ! replies1 h[ev]1 ! foll[+ summ>y result$3 #a 0 worse ?an #b or #c 9 #f cases4 #b 0 worse ?an #a or #c 9 #e cases4 #c 0 worse ?an #b or #a 9 #a case4 ,! report f ,johns ,hopk9s records a s]ies ( #aag injections foll[$ by ! e/imat$ reactions record$ bel[3 #a4 ,sev]e1 #ac2 mild1 #ad2 none1 #d2 unrecord$1 #h #ci #b4 ,sev]e1 #e2 mild1 #ae2 none1 #af2 unrecord$1 #e #da #c4 ,sev]e1 #g2 mild1 #be2 none1 #c2 unrecord$1 #b #cg ,t is1 :5 record$ 9 p]c5tages3 #a4 7,b9iodol7 sev]e1 #cc4c2 mild1 #ce4i2 none1 #aj4c2 unrecord$1 #bj4e4 #b4 7,)\t guaiacol7 sev]e1 #ab4b2 mild1 #cf4h2 none1 #ci4j2 unrecord$1 #ab4b4 #c4 7,) guaiacol7 sev]e1 #ah4i2 mild1 #fg4e2 none1 #h4a2 unrecord$1 #e4e4 ,! manufactur] ( ,b9iodol suppli$ ! names ( sev]al physicians :o h us$ t prep>ation 9 _! practice4 ,correspond5ce ) ^! elicit$ ! foll[+ /atem5ts3 ,"o _h us$ ,b9iodol 9 =ty-eight cases & /ates t 8only a few pati5ts compla9 ( pa9 at all & !n only ( a g5]al sor5ess 9 ! muscle40 ,?is physician reports a limit$ exp]i5ce ) ! use ( ano!r manufactur]'s 8m]cury b9iodide oil solution0 7app>5tly six cases71 b sev]e pa9 foll[+ ! injections made x necess>y to ab&on t prep>ation4 ,ano!r ( ^! physicians nam$ by ! manufactur]1 )\t ref]5ce to any s]ies ( cases1 reports t 8,b9iodol is sup]ior to any oily solution ( m]cury b9iodid t ,i h tri$40 ,a ?ird physician has 8us$ x ,b9iodol a few times0 & is 8conv9c$ t x has no special action or virtue0 ov] 8any r$ m]curic iodide 9 oil40 ,?is evid5ce1 9 its mo/ favorable e/imate1 %[s ,b9iodol to be a good #a p] c5t4 solution ( m]curic iodid 9 oil1 b fails to ju/ify attribut+ to ! prep>ation any unique *>act]i/ics4 ,! prep>ations made 9 ! laboratory 7 z satisfactory1 or bett] ?an ! ,b9iodol1 & ! pres5ce or abs5ce ( ! guaiacol 0 ( no consequ5ce4 ,b9iodol conflicts ) ,rule #f1 s9ce claims ( sup]ior !rapeutic effici5cy made = x are n e/abli%$2 & ) ,rules #h & #aj1 s9ce x is an uness5tial modification ( an e/abli%$ nonpropriet>y article m>ket$ "u a propriet>y "n4 ,9 view ( ! =ego+1 ! ref]ee recomm5ds t ,b9iodol be n accept$ = ,new & ,non(ficial ,rem$ies1 & t ?is report1 includ+ ! cl9ical inve/igations ( ,drs4 ,cole & ,keidel1 be au?oriz$ = publication4 ,,comp>ative ,,symptoms ,,result+ ,,f ,,! ,,use ,,( ,,sev]al ,,oily ,,susp5sions ,,( ,,r$ ,,m]curic ,,iodid 7,,m]cury ,,b9iodid7 ,report ( ,dr4 ,h4 ,n4 ,cole,c ,c ,f ! ,dep>tm5t ( ,d]matology & ,syphilology ( ! ,we/]n ,res]ve ,univ]sity & ( ! ,clevel& ,city ,hospital4 ,at ! reque/ ( ,pr(4 ,torald ,sollmann ( ! ,c\ncil on ,ph>macy & ,*emi/ry ( ! ,am]ican ,m$ical ,association1 we made a comp>ative /udy ( sev]al oily prep>ations ( r$ m]curic iodid = intramuscul> injections 9 syphilis4 ,! in=mation1 conc]n+ ! prep>ations submitt$ to ! inve/igators1 0 z foll[s3 ,,oily ,,solution ,,( ,,r$ ,,m]curic ,,iodid 8,x is desir$ to asc]ta9 :e!r !re is any diff]5ce betwe5 ?ree prep>ations1 ea* conta9+ #a p] c5t4 ( m]curic iodid1 z to pa91 discom=t1 induration1 etc4 ,! prep>ations w be label$ 8#a10 8#b0 & 8#c40 ,!y w be /]ile4 8,"o ( ^! prep>ations w be a pla9 solution 9 oil2 ano!r w conta91 9 addition1 #b4e p] c5t4 ( guaiacol2 ! ?ird w be a propriet>y prep>ation conta9+ ! guaiacol4 8,x is also desirable to "k h[ ! oily solution comp>es ) ! pla9 wat]y solution2 b ?is is ( second>y importance40 ,! prep>ations all _h ! same appe>ance4 ,! pati5ts 7 tak5 indiscrim9ately1 & we attempt$ to keep !m on ! injections z long z possible1 9 ord] to comp>e symptoms4 ,ow+1 h[ev]1 to dis*>ge f hospital1 symptoms ( m]cury intoxication1 etc41 we 7 unable 9 all cases to give a ?or\gh trial ) ea* prep>ation4 ,9 all1 elev5 pati5ts 7 treat$ & sev5ty-"o injections giv5--by :i* "t our exp]im5tal supply 0 exhau/$4 ,9 ea* case ! drug 0 giv5 intramuscul>ly 9 ! buttocks & ! pati5ts c>efully obs]v$ = subjective symptoms ( pa9 & = objective symptoms ( swell+1 induration1 abscess =mation1 etc4 ,! details are giv5 9 ,table #a4 ,z w be not$1 9 sev]al ( ! cases ! pati5ts 7 m or less confus$ & gave r indef9ite & conflict+ answ]s4 ,9 attempt+ to comp>e ! results f ! diff]5t drugs1 by c>eful tabulation "o f9ds t symptoms 7 m m>k$ ) ! respective sample z foll[s3 ,prep>ation #a 0 worse ?an ,prep>ation #b or #c 9 six cases4 ,prep>ation #b 0 worse ?an ,prep>ation #a 9 two cases4 ,prep>ation #b 0 worse ?an ,prep>ation #c 9 five cases4 ,prep>ation #c 0 worse ?an ,prep>ations #b or #a 9 "o case4 ,,table #a4--;,,details ,,( ,,inve/igation ,,by ,,dr4 ,,cole99 ,symptoms ,prep>-,dose1 ----------------------------- ,case,age,sex ,date ation ,gra9 ,induration-- ,objective ,pa9 ---------------------------------------- ------------------------ #a #be #f_/aa_/af #b #a_/e ,none ,/ill pa9ful #f_/ab_/af #a #a_/d ,none ,none #f_/ac_/af #b #a_/e ,none ,q pa9ful #f_/ad_/af #b #a_/d ,hurt = "s ,v t5d] "t #f_/af_/af #b #a_/e ,hurt = "s ,v t5d] "t #f_/ag_/af #c #a_/e ,n s pa9ful ,less t5d] ?an ) ,prep>- ation #b4 #f_/ah_/af #c #a_/e ,n s pa9ful ,c sit on ,discont9u$ area2 z 7salivation7 ne$le prick is only place t x hurts #f_/bb_/af #b #a_/d ,hurt1 b n ,slight indur- s long ation & slight t5d]ness #f_/bd_/af #b #a_/d ,hurt1 b n ,pa9 8dead s long /++0 la/s #a h\r #f_/be_/af #a #a_/d ,n s bad ,ab\t ! same ---------------------------------------- ------------------------ #b #cb #f_/bd_/af #b #a_/d ,"s pa9 ,no induration #f_/be_/af #a #a_/d ,m pa9 ,slight indur- ation ---------------------------------------- ------------------------ #c 44 #f_/ab_/af #a #a_/e ,no symptoms ,pa9ful #f_/ac_/af #b #a_/d ,no symptoms ,pa9ful #f_/ad_/af #b #a_/d ,says ! la/ ,pa9ful #f_/af_/af ,ars5o- two h hurt b5zol ! m #f_/ag_/af #c #a_/e ,m pa9 ?an ,small pa9ful previ\sly area #f_/ag_/af #c #a_/e #f_/ah_/af #c #a_/e ,n s mu* ,"s indur- pa93 9 ation at site #f_/ai_/af #c #a_/e fact1 pati5t ( injections #f_/bj_/af #c #a_/d says he is #f_/ba_/af #c #a_/d ov] x 9 a v %ort :ile2 com- pla9$ ( la/ "o #f_/bb_/af #b #a_/d ,"s pa9 ,consid]able t5d]ness #f_/bd_/af #b #a_/d ,n s mu* z n[ aft] s previ\sly _m injec- #f_/be_/af #a #a_/d tions ---------------------------------------- ------------------------ #d #cf #f_/bb_/af #b #a_/d ,no pa9 ,no t5d]ness #f_/bd_/af #b #a_/d ,"s pa9 ,"s t5d]- ness #f_/be_/af #a #a_/d ,c\ld n sleep,"s t5d]- at night ness2 slight induration ---------------------------------------- ------------------------ #e #cb #f_/bj_/af #c #bj ,"s pa9 ,no induration m9ims #f_/ba_/af #c #be ,"s pa9 m9ims #f_/bc_/af #b #a_/d ,worse pa9 ,no induration #f_/bd_/af #b #a_/d ,worse pa9 #f_/be_/af #a #a_/d ,worse ?an any ,slight t5d]- ness ---------------------------------------- ------------------------ #f #bj #f_/ #h_/af #a #a_/f ,v little #f_/aj_/af #a #a_/e ,v little #f_/ac_/af #a #a_/d ,v little #f_/ad_/af #b #a_/d ,bo!r$ m ?an o!rs #f_/ag_/af #b #a_/e ,q a little ,/ill "s pa9 sor5ess #f_/ah_/af #b #a_/e ,q a little ,/ill "s pa9 sor5ess #f_/ai_/af #c #a_/d ,consid]ably ,v little less pa9 ?an t5d]ness #f_/bj_/af #c #a_/d ) ,prep>- #f_/ba_/af #c #a_/d ation #b ---------------------------------------- ------------------------ #g #cj #f_/ab_/af #a #a_/e ,little pa9 ,none #f_/ac_/af #b #a_/d ,no pa9 #f_/ad_/af #b #a_/e ,"s pa9 #f_/af_/af ,ars5o- b5zol #f_/ag_/af #c #a_/e ,n s mu* ,no t5d]ness #f_/ah_/af #c #a_/e ,n s mu* ,no t5d]ness #f_/ai_/af #c #a_/e ,v little ,only slight pa9 am\nt ( #f_/bj_/af #c #a_/d induration #f_/ba_/af #c #a_/d #f_/bb_/af #b #a_/d ,"s pa9 ,"s little induration #f_/bd_/af #b #a_/d ,consid]able ,"s indura- pa9 tion #f_/be_/af #a #a_/d 8,f9e0 ,slight indura- tion ---------------------------------------- ------------------------ #h #bh #f_/ac_/af #b #a_/e ,little pa9 ,little pa9 aft]w>d #f_/ae_/af #b #a_/e ,little pa9 ,little pa9 aft]w>d ---------------------------------------- ------------------------ #i #bh #f_/ag_/af #b #a_/e ,"s compla9t ,v little ( pa94 induration #f_/ah_/af #b #a_/e ,fairly sev]e #f_/ai_/af #c #a_/e ,"s pa92 says,v slight ^! h induration #f_/bj_/af #c #a_/d hurt v mu* #f_/ba_/af #c #a_/d less ?an o!rs ---------------------------------------- ------------------------ #aj #cg #f_/ab_/af #a #a_/e ,no symptoms ,none #f_/ac_/af #a #a_/d ,no symptoms ,none #f_/ad_/af #a #a_/e ,no symptoms ,none #f_/ae_/af #c #a_/e ,no symptoms ,none #f_/af_/af ,ars5o- b5zol #f_/ag_/af #c #a_/e 8,mu* less pa9,none ?an b9iodid or grey oil0 #f_/ah_/af #c #a_/e ,no compla9t ,none #f_/ai_/af #c #a_/e ,says he is ov],"s indura- #f_/bj_/af #c #a_/d x 9 "o h\r tion at site #f_/ba_/af #c #a_/d ( injection ---------------------------------------- ------------------------ #aa #cj #f_/aa_/af #a #bj ,consid]able2 ,consid]able m9ims n s mu* pa9 & #f_/ab_/af #b #bj t5d]ness on m9ims palpation ov] area #f_/ac_/af #a #be ,n mu* pa9 ,indurat$ area m9ims at pt4 ( ea*4 ,pa9ful #f_/ad_/af #a #be ,n mu* pa9 ,slight indura- m9ims tion ---------------------------------------- ------------------------ 99 ,! diagnosis 9 ,case #e 0 prim>y syphilis1 & 9 ! o!r cases1 second>y syphilis4 ,9 ?is column1 indicates male1 & female4 ,9 no case did ,wass]mann become negative4 ,! criticism may be rais$ t ! numb] ( cases & ( injections is too small to p]mit ! draw+ ( any j conclusions4 ,ev5 %\ld we grant x1 ! /ati/ics c]ta9ly d n prove any m>k$ sup]iority ( any "o ( ! prep>ations ov] ! o!rs4 ,we wi% to ?ank ,dr4 ,sollmann = advis+ & direct+ u 9 ?is "w1 & ,drs4 ,bailey1 ,b]n/e91 ,m>kus & ,reycraft = assi/ance 9 c>ry+ x out4 ,report ( ,dr4 ,alb]t ,keidel ,tw5ty cases 7 *os5 at r&om f ! syphilitic pati5ts att5d+ ! cl9ic4 ,!y 7 giv5 intramuscul> injections ( ! ?ree solutions1 9 am\nts v>y+ f #a to #b c4c41 at int]vals 79 mo/ in/ances7 ( two days4 ,! injections 7 inv>iably made into ! gluteal muscles1 at dep?s ( f #b to #b-a_/b in*es1 & ord9>y c>e ex]cis$ to pres]ve asepsis4 ,aft] injection ! pati5t 0 all[$ to dep>t1 & ! result 0 record$ at ! succe$+ visit4 ,! result 0 det]m9$ f ! pati5t's /atem5t & our exam9ation4 ,"s pati5ts receiv$ injections ( only "o solution2 "s 7 treat$ ) fir/ "o & lat] ) ano!r1 & "o pati5t receiv$ all ?ree at diff]5t times4 ,! solutions 7 nev] mix$ = a s+le injection1 ( c\rse4 ,,table #b4--,,reactions ,,9 ,,tw5ty ,,cases ,,report$ ,,by ,,dr4 ,,keidel ,prep>ation ,reactions ,numb] ( ,injections ,sev]e ,mild ,none ,undet]m9$ #a #ac #ad #d #h #ci #b #e #ae #af #e #da #c #g #be #c #b #cg --- #aag ---------------------------------------- -------------------------- ,! solutions are und]/ood to conta9 a #a p] c5t4 solution ( r$ m]curic iodid 9 oil1 two ( !m conta9+ 9 addition #b4e p] c5t4 ( guaiacol1 "o ( ^! be+ a propriet>y prep>ation4 ,! solutions are designat$ z ,prep>ations #a1 #b & #c1 respectively1 correspond+ to ! numb]s on ! labels ( ! bottles 9 :i* !y 7 orig9ally receiv$4 ,! local reactions are record$ z 8sev]e0 7,s71 8mild0 7,m71 8none0 7,o7 & 8,undet]m9$0 7,u74 ,by 8sev]e0 is meant v sev]e pa9 la/+ = f sev]al h\rs to sev]al days2 by 8mild0 is meant slight pa9 or numbness = sev]al h\rs1 or less ?an an h\r2 8none0 indicates t !re 0 no local reaction1 & 8undet]m9$10 t ! pati5t has fail$ to return aft] ! la/ injection4 ,9 ,table #c all ! details ( ! inve/igation are record$4 ,"u 8,local ,reaction10 ! lett]s repres5t ! type ( reaction aft] ea* injection1 9 ! ord] 9 :i* !y 7 giv52 :5 two solutions 7 us$ 9 ! same case1 ! lett]s repres5t ! reactions foll[+ ! solution opposite :i* !y /&4 ,9 ! fif? column ! plus & m9us symbols indicate ! ,wass]mann reaction2 plus indicates a completely positive1 & m9us a completely negative reaction4 ,:5 !re is only "o sign1 x ref]s to ! reaction at ! end ( treatm5t2 :5 !re are two1 to ! reaction be=e & aft]4 ,! sev5? column %[s ! cl9ical result at ! end ( treatm5t2 :5 no note is made1 x means t !re 0 no *ange not$4 ,9 ! eigh? column are not$ any objective results obs]v$ at ! "t ( exam9ations ( ! pati5ts4 ,! injections 7 made & ! result *>t$ by ,dr4 ,e4 ,l4 ,zimm]mann1 ( my /aff1 "u my directions & sup]vision4--7,ab/ract$ 9 ,! ,j\rnal ,a4 ,m4 ,a41 ,feb4 #bd1 #aiag47 ,,table #c4--;,,details ,,( ,,inve/igation ,,by ,,dr4 ,,keidel ,total ,dura- ,effect ,case,no4,prep>- ,local ,am\nt tion on ,type ( ,result ,g5]al ation ,reaction ,solution ( ,wass]- ,case ,rem>ks ,giv51 ,treat- mann ,c4c4 m5t ---------------------------------------- ------------------------------------ #a #c #b ,,ooo #c #f da4 ,lat5t #b #e #b ,,mosms #e4f #i da4 ,gummas4444,m>k$ #c #g #a ,,mmm2 #i4e #c mo4- to ,lat5t improve- o!rs ,u m5t #c #b ,,uuu #d #a #b ,u #j4ge 444 ,lat5t #e #d #a ,,sssm #d4d #i da4 - ,gummas44444444444444,aft] #d? injection1 develop$ di>rhea2 mel5a #f #i #a ,,o\msosmu #i4a #a mo4 - ,lat5t #g #b #c ,,mm #c4h #b da4 ,lat5t 4444444444,well tol]at$ #h #g #b ,,oooom\ #i4f #ag da4 to ,prim>y444,prim>y heal$ #i #d #a ,,smmu #e4e #i da4 ,gumma44444,improv$ #aj #c #c ,,mss #c #f da4 ,palm> ,m>k$ly syphilis2 improv$ t]ti>y #aa #g #c ,,msmmmmm #aj4f #ac da4 to ,lat5t #ab #c #b ,,mmo #e4d #ad da4 ,second>y ,ra% ,develop$ #b #a ,,sm 7papul>7 disap- toxic ery- pe>+4 !ma on ?ighs4 ,cle>$ up on /opp+ ,hg,cl & "u local treatm5t #ac #aj #c ,,mmmmmmmm #ab4f #bj da4 to ,second>y ,ra% ,small ,,mmu 7li*5 n induration syph47 improv$4 foll[+ injection ( #a4b c4c4 #ad #f #b ,,oomsmm #g4b #ag da4 to ,old 4444444444,respond$ to #b #a ,,sm c]ebro- doses ( sp9al #a c4c4 ) syphilis salivation2 fev] aft] injection ( #a4b c4c4 #ae #d #a ,,soms #d4b #g da4 to ,second>y ,no 7condyl- improve- omas7 m5t #af #i #c ,,omommsmso #aj4d #ab da4 ,second>y ,pu/ules ,slight #b #b ,,s 7pu/ul> dri$ up2 g+ivitis syph47 heada*e foll[+ & fev] dose ( gone #a4e c4c4 #ag #e #a ,,ssmsu #ac4c #ah da4 to ,t]ti>y2 ,g5]al #b #b ,,ms aortitis4 condition #b #c ,,ms improv$ #ah #d #b ,,oomm #i4e #ac da4- to ,lat5t #b #a ,,mm ,m>k$ly improv$ #ai #b #c ,,mu #b4e #e da4 ,gumma44444 #bj #e #b ,,mmmmo #i #ad da4 to ,lat5t4444,m>k$ ,small #b #c ,,ms g5]al induration improve- foll[+ m5t ,no4 #c ---------------------------------------- ------------------------------------ ,,corpora ,,lutea 7,,soluble ,,extract71 ,,p>ke1 ,,davis ,,co4 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,foll[+ inquiries1 ! ,c\ncil took up = consid]ation 8,corpora ,lutea 7,soluble ,extract710 m>ket$ by ,p>ke1 ,davis ,co4 9 ! =m ( ampules & propos$ = hypod]mic adm9i/ration4 ,! report :i* appe>s bel[ 0 submitt$ to ! ,c\ncil by a committee1 & 0 adopt$ by ! ,c\ncil4 ,corpora ,lutea 7,soluble ,extract7 0 decl>$ inadmissible to ,new & ,non(ficial ,rem$ies1 & publication ( ! report au?oriz$4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,corpora ,lutea 7,soluble ,extract7 has n be5 submitt$ by ! manufactur]4 ,! in=mation ( ! ref]ee is bas$1 !re=e1 on ! claims made 9 ! trade package1 & on ! /atem5ts 9 ! price li/4 ,^! %[ t ! product is ess5tially secret & claims made = ! actions & uses ( ! prep>ation d n make cle> ! ess5tially exp]im5tal /atus ( ! article1 & are !re=e mislead+4 ,conflict ) ,rule #a4--,no def9ite /atem5t ( composition appe>s beyond ! indef9ite claim t x is an aque\s solution ( 8soluble ,corpora ,lutea ,extract10 ea* ampule correspond+ to #j4b ,gm4 ( desiccat$ gl&4 ,h[ ^! soluble products are obta9$1 :e!r !y repres5t all ! wat]-soluble pr9ciples1 or :e!r "s h be5 elim9at$1 are que/ions t are n answ]$4 ,yet su* in=mation is ess5tial to intellig5t & sci5tific use1 =1 z !re is no me?od ( /&>dization1 ! me?od ( prep>ation is ! only m>k ( id5tity4 ,= in/ance1 we d n "k at ?is "t :e!r prote9s h any?+ to d ) ! suppos$ value ( corpora lutea4 ,x is1 !re=e1 ess5tial to "k :e!r or n ! prote9s h be5 elim9at$4 ,conflict ) ,rule #f4--,! circul> 9 ! package advises ! hypod]mic use ( ?is extract1 n only 9 functional am5orrhea & ! ord9>y reflex consequ5ces ( physiologic or artificial m5opause1 b also 93 8#8neura/h5ic' symptoms dur+ m5/rual life02 8/]ility1 n due to pyog5ic infection or me*anical ob/ruction02 8repeat$ abortions1 n due to disease or me*anical factors02 8hyp]emesis 9 ! e>ly mon?s ( pregnancy40 ,^! are n /at$ m]ely z conditions 9 :i* v>i\s en?usia/s h tri$ corpus luteum1 b z conditions 8= :i* x w be f\nd s]viceable40 ,x is n necess>y to in=m ! m$ical pr(ession t ?is /atem5t is calculat$ to raise expectations :i* _c possibly be fulfill$4 ,ev5 ! manufactur]s seem to realize ?is2 at lea/ !y speak some:at indef9itely ( 8suitable cases10 8good judgm5t10 8real indications10 etc4 ,b !y proce$ to nullify ?is w>n+--if x 0 int5d$ z a w>n+--by _! illu/rations ( unsuitable cases1 = in/ance1 8am5orrhea due to extreme anemia1 dysm5orrhea due to c]vical /5osis10 etc4 ,f9ally1 !y sum up ! case3 8,!re=e1 additional emphasis on ! necessity = ! prop] selection ( cases is ess5tial 9 ord] t ?is useful prep>ation may n be unju/ly discr$it$40 ,h[ ^! cases ( /]ility1 abortions1 etc41 are to be select$ is n reveal$4 ,9 o!r words1 ! re/riction is no m ?an a conv5i5t device by :i* e improvem5t is to be attribut$ to ! m$ic9e1 & e failure to ! physician4 ,! ref]ee recomm5ds t ,corpora ,lutea 7,soluble ,extract71 ,p>ke1 ,davis ,co41 be held ineligible to ,n4 ,n4 ,r41 because x is a secret prep>ation adv]tis$ "u extravagant claims4 ,editorial ,comm5t4--,0 x n 9 ,weir ,mit*ell's 8,adv5tures ( ,franois0 t ! it9]ant promis$ to pull tee? )\t any pa91 if ! pati5t w\ld hold absolutely /ill8 ,&1 mirabile dictu1 ! ones :o suff]$ 7 ^? :o _h n held absolutely /ill6--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,april #g1 #aiag47 ,,:eel]',s ,,tissue ,,phosphates ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil held t ! contribution f ! ,a4 ,m4 ,a4 ,*emical ,laboratory1 8,:eel]'s ,tissue ,phosphates10 demon/rates t ?is is a semisecret1 complex & irrational prep>ation1 sold ) mislead+ claims conc]n+ its m$ic9al con/itu5ts & !rapeutic prop]ties4 ,! ,c\ncil direct$ t ! report be includ$ ) ! ,annual ,c\ncil ,reports & decl>$ ,:eel]'s ,tissue ,phosphates 9 conflict ) ,rules #a1 #f1 #h & #aj4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,,:eel]',s ,,tissue ,,phosphates ,l4 ,e4 ,w>r51 ,ph4,c41 ,b4,s4 8,:eel]'s ,tissue ,phosphates10 kn[n also z 8,comp\nd ,elixir ( ,phosphates & ,calisaya10 is adv]tis$ z a n]ve food & a nutritive tonic4 ,! label /ates t x conta9s calcium1 iron1 sodium trihydrog5 phosphates1 alkaloids ( ,p]uvian b>k ) #ab-a_/b p] c5t4 ( alcohol4 ,! prep>ation is sold by ! ,t4 ,b4 ,:eel]1 ,m4 ,d4 ,co41 ( ,r\ses ,po9t1 ,new ,york4 ,accord+ to ! manufactur]1 ,:eel]'s ,tissue ,phosphates 8444 is an inorganic comb9ation ( ! phosphates ( iron & calcium & hydrog5 7phosphoric acid7 toge!r ) hydro*loric acid1 hydrocyanic acid1 & qu99e1 *e]ful color+1 & a delici\s1 cordial-l flavor+40 8444 ,! iron is ! gre51 inorganic phosphate & ! calcium ! simple :ite phosphate ( y\r e>ly /ud5t days44440 ,! prep>ation is a r$ liquid1 hav+ an acid reaction1 a sweet-bitt] ta/e & ! odor ( wild *]ry4 ,qualitative te/s indicat$ ! pres5ce ( calcium1 iron1 a phosphate1 a *lorid1 a sulphate1 qu99 or c9*ona alkaloids1 alcohol1 sodium1 co*9eal color+ & inv]t sug>4 ,ammonium salts1 glyc]ol1 citrates or lactates 7 n f\nd4 ,f ! quantitative values obta9$ ! prep>ation may be tak5 to repres5t3 ,sp4 gr at #be;,c4_/#be;,c4 #a4ajhg ,alcohol 7p] c5t1 by volume7 #aa4ce ,gm4 p] #ajj c4c4 ,calcium phosphate ,ca7,,po799 #j4cig ,iron phosphate 7,fe,p,o4#d;,h,o799 #j4jfh ,*lorid 7z hydro*loric acid7 #j4djg ,sodium sulphate 7,na,,s4#aj;,h,o7 #j4jdc ,qu99 sulphate 7,u4 ,s4 ,p47 #j4jda ,sodium phosphate 7,na,,hpo4#ab;,h,o7 #j4jfe ,inv]t sug> #bf4hbd ,wat]1 co*9eal & flavor1 to make #ajj c4c4 99 ,x %\ld be und]/ood t ! calcium & iron salts are held 9 solution by ! hydro*loric acid4 ,! dose ( ,:eel]'s ,tissue ,phosphates recomm5d$ by ! manufactur] is a tablespoonful or ab\t #ae c4c4 7#a_/b oz474 ,! total calcium 9 a dose ( ! prep>ation is equival5t to ab\t "o-six? ( an av]age dose ( ! (ficial calcium *lorid1 & ! total phosphate to ea* dose is equival5t to ab\t "o-f\r? ( a dose ( ! (ficial dilut$ phosphoric acid4 ,ea* prescrib$ dose ( ! prep>ation conta9s ab\t #j4ja gm4 7#b_/ac gra97 ( iron phosphate or ab\t "o tw5ty-fif? ( ! av]age dose1 & to obta9 a ,ph>macopeial dose ( iron phosphate ! pati5t w\ld be oblig$ to take ?ree-f\r?s ( ! cont5ts ( an entire bottle--or #ab ounces--( ! prep>ation4 ,if x be assum$ t all ( ! *lorid pres5t is 9 ! =m ( free hydro*loric acid1 ea* dose ( ! prep>ation conta9s ! equival5t ( ab\t two-?irds ( "o ,ph>macopeial dose ( dilut$ hydro*loric acid4 ,ea* dose ( ! prep>ation conta9s ab\t #j4jjfb gm4 7#a_/aj gra97 ( qu99 sulphate1 or ab\t "o-sixte5? ( ! av]age tonic dose4 ,9 o!r words1 to obta9 ! am\nt ( qu99 sulphate giv5 9 ! ,u4 ,s4 ,ph>macopeia z ! tonic dose1 ! pati5t w\ld be requir$ to swall[ #g-a_/b fluid\nces ( ! propriet>y prep>ation1 or ! cont5ts ( ne>ly half a bottle4 ,! fallacy ( prescrib+ ,:eel]'s ,tissue ,phosphates ei!r = its qu99 or its iron cont5t is app>5t4 ,:eel]'s ,tissue ,phosphates is1 !n1 a mildly bitt] flavor$ syrup :i* conta9s ne>ly #ab p] c5t4 ( alcohol1 small quantities ea* ( calcium phosphate & hydro*loric acid & insignificant am\nts ( iron & qu99 salts4 ,9 o!r words1 ess5tially x is a sweet5$ solution ( small quantities ( calcium phosphate 9 v dilute hydro*lorid acid toge!r ) #ab p] c5t4 ( alcohol4 ,be>+ 9 m9d ! analysis ( ! prep>ation1 h[ ludicr\s "s ( ! claims appe>3 8,tissue ,phosphates is n a hypophosphite prep>ation2 x is n a comb9ation ( glyc]ophosphates or o!r organic salts1 or s-call$ peptonates & manganates1 all rec5tly condemn$ by ! be/ !rapeutic op9ion "h & 9 ,europe1 z mu* sl[] & less active ?an ! simpl] salts4 ,! iron is ! gre51 inorganic phosphite & ! calcium ! simple :ite phosphate ( y\r e>ly /ud5t days4 ,nature takes ^! simple salts & builds !m rapidly into leci?91 bone1 & o!r tissue1 )\t ! delay incurr$ by splitt+ up ! organic salts be=e %e c recomb9e !m40 8,tissue phosphates is 9 fact a *emical food40 8,! =mula1 sugge/$ by ,pr(essor ,dus>t1 ( ,p>is1 comb9es 9 an easily assimilable & agreeable cordial2 m$ium m$ic9al doses ( ,phosphorus1 ! ,g5]ator ( ,n]ve ,=ce2 ,calcium ,phosphate1 = ,cell ,developm5t & ,nutrition2 ,sodium ,phosphate1 a /imulant ( ,liv] & ,pancreas & ,corrective ( ,acid ,f]m5tation 9 ! ,alim5t>y ,canal2 ,iron1 g5]at+ 9 ! ,blood1 ,heat & ,motion1 ,phosphoric ,acid1 ,tonic 9 ,sexual ,debility2 ,alkaloids ( ,calisaya1 ,antimal>ial & ,antipyretic2 ,extract ( ,wild ,*]ry1 ,tonic1 yet ,calm+ ,irritation & ,dim9i%+ ,n]v\s ,excitem5t2 ,e?yl ,alcohol #ab4e2 & ,aromatics40 ,al?\gh ! claim is made t ! 8=mula0 ( ,:eel]'s ,tissue ,phosphates has be5 8sugge/$ by ,pr(essor ,dus>t10 su* ( ,dus>t's pap]s z 7 available 9 ?is c\ntry#aaa fail$ to disclose any 8=mula0 t 0 at all comp>able to ?is product4 #aaa ,dus>t1 ,l43 ,re*]*es exprim5tales sur le rle physiologique et ?rapeutique du phosphate de *aux1 ,p>is1 #ahgj2 ,quel e/ l'acide du suc ga/rique8 ,lille1 #ahgd1 unb\nd1 #h pages2 ,notice sur l'emploi et les propriets du lacto-phosphate de *aux1 ,cli*y1 #ahfh1 unb\nd1 #h pages4 ,dus>t & ,bla*e3 ,re*]*es sur l'assimilation du phosphate de *aux1 ,p>is1 #ahfh1 unb\nd1 #ae pages4 ,editorial ,note4--,! inve/igation v]ifies facts t mu/ be obvi\s to e physician :o has giv5 ! matt] ?\ght4 8,:eel]'s ,tissue ,phosphates0 is an unsci5tific1 %otgun mixture ^: mo/ active & p[]ful drug is ! alcohol x conta9s4 ,t x 0 n ye>s ago relegat$ to ! realms ( obsolete & disc>d$ prep>ations is a comm5t>y alike on ! lack ( sci5tific discrim9ation & ! p]suasive p[] ( adv]tis+4 ,:ile 9 ! pa/ 8,:eel]'s ,tissue ,phosphates0 has be5 adv]tis$ ext5sively 9 m$ical j\rnals1 x seems t n[ ! *ief1 if n ! only b5efici>y ( ! adv]tis+ appropriation = ?is product is ! ,new ,york ,m$ical ,j\rnal1 :i* weekly h]alds ! 8,delici\s0 & 8,su/a9+0 qualities ( 8,! ,ideal ,tonic = ,fa/idi\s ,convalesc5ts40--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,may #e1 #aiag47 ,,! ,,claim$ ,,galactagogue ,,effects ,,( ,,nutrolactis ,,& ,,goat',s ,,rue ,,n ,,sub/antiat$ ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,specific lactagogues--drugs :i* /imulate ! secretion ( milk--are unkn[n to sci5ce4 ,yet m$ical publications give space to adv]tisem5ts ( a propriet>y--8,nutrolactis0--:i* is said to increase ! milk supply ( nurs+ mo!rs4 ,s9ce dep5d5ce on a prep>ation ( ?is k9d is likely to cause neglect ( ! only means ( increas+ a scanty milk supply ( nurs+ mo!rs--c>e ( ! g5]al heal? & a suffici5t quantity ( prop] food--?is propriet>y & ! drug 8goat's rue10 7,galega (fic9alis7 :i* ! proprietors h9t z be+ ! pot5t con/itu5t1 7 subject$ to a critical /udy to det]m9e _! possible influ5ce on milk secretion4 ,= ?is purpose ! ,c\ncil secur$ ! help ( ,a4 ,j4 ,c>lson1 ,ph4,d41 pr(essor ( physiology1 ,univ]sity ( ,*icago4 ,dr4 ,c>lson1 ) ! aid ( ,a4 ,woelfel1 ,m4,d41 & ,m>ian ,lewis1 ,sc4,m41 und]took to e/imate ! effect ( ,nutrolactis & ( goat's rue on nurs+ dogs & goats ) ! int5tion ( ext5d+ ! /udy to nurs+ mo!rs if ! animal exp]im5ts s w>rant$4 ,! contribution1 8,! ,alleg$ ,galactagogue ,action ( ,galega & ,nutrolactis10 by ,m>ian ,lewis & ,a4 ,j4 ,c>lson f ! ,hull ,physiological ,laboratory ( ! ,univ]sity ( ,*icago1 :i* appe>s bel[1 %[s t ,nutrolactis & goat's rue are )\t influ5ce on ! milk secretion 9 nurs+ animals4 ,! ,c\ncil endors$ ! "w ( ,lewis & ,c>lson & held t ! claim$ galactagogue effects ( ,nutrolactis & goat's rue are n sub/antiat$4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,,! ,,alleg$ ,,galactagogue ,,action ,,( ,,galega ,,& ,,nutrolactis,d ,m>ian ,lewis1 ,sc4,m41 & ,a4 ,j4 ,c>lson1 ,ph4,d4 ,,*icago ,d ,f ! ,hull ,physiological ,laboratory ( ! ,univ]sity ( ,*icago4 ,d ,?is inve/igation 0 begun 9 #aiae by ,drs4 ,a4 ,woelfel & ,a4 ,j4 ,c>lson4 ,x is well e/abli%$ t ! food be/ adapt$ to ! en]gy & gr[? requirem5ts ( ! infant is normal "m's milk4 ,any decrease 9 quantity or det]ioration 9 quality ( ! mat]nal secretion is soon foll[$ by a p>allel impairm5t ( gr[?1 loss ( weight1 or l[]$ resi/ance to infection 9 ! infant4 ,! widespread occurr5ce ( defici5t milk secretion is a matt] ( common k4 ,! discov]y ( true lactagogues1 or specific sub/ances :i* increase ! quantity & quality ( ! milk on be+ adm9i/]$ to nurs+ mo!rs1 w\ld !re=e be ( v great importance4 ,9 view ( ?is great m$ical & economic int]e/ 9 true lactagogues x is n surpris+ to f9d t ! m$ical & biologic lit]ature records discov]ies ( lactagogues bas$ on hope r ?an demon/ration1 & t spuri\s lactagogues are on ! m>ket4 ,"s ( ! factors kn[n to affect milk secretion are g5]al heal?1 food supply1 psy*ic /ate1 & h]$ity4 ,! me*anism ( secretion & ! me?od by :i* ^! factors affect x are imp]fectly und]/ood4 ,9 g5]al x has be5 obs]v$ t milk yield improves bo? 9 quantity & 9 quality ) improvem5t 9 g5]al heal?1 bett] food supply1 & m favorable psy*ic /ate4 ,! influ5ce ( h]$ity is tak5 advantage ( by dairym5 :o are well acqua9t$ ) ! pot5tial milk production ( ! diff]5t bre$s ( cattle4 ,among ! sub/ances :i* h be5 report$ to /imulate milk secretion may be m5tion$ ! extract ( ! po/]ior lobe ( ! hypophysis4 ,b pituit>y extract is n a true lactagogue1 because its action is conf9$ to ! smoo? musculature ( ! gl& ducts1 caus+ a m or less complete ejection ( ! milk already =m$2 x has no effect on ! gl& cells or ! actual secretory process 9 ! direction ( increas+ ! milk yield4 ,extracts ( ?ymus1 corpus luteum1 ov>ies1 ut]us1 plac5ta1 fetus1 & ! mamm>y gl& itself h also be5 report$ to h a tempor>y /imulat+ effect on ! quantity ( milk secret$1 b :5 ^! extracts are giv5 by m\? !y are app>5tly )\t specific influ5ce on ! mamm>y gl&4 ,galega1 or goat's rue 7,galega (fic9alis71 is an h]b describ$ 9 ! ,national ,=mul>y z be+ slightly bitt] & a/r+5t4 ,9 #ahgc1 ,gillet-,damotti1#aab 9 a communication to ! ,fr5* ,academy1 /at$ t ?is plant :5 f$ to c[s increases ! secretion ( milk f #ce to #ej p] c5t4 ,o!r ,fr5* writ]s h affirm$ t goat's rue is a lactagogue4 ,9 ,g]many1 ,fragn]#aac made a prep>ation call$ ,galegal1 us+ galega z ! active pr9ciple & comb9+ x ) lactose to give x a pleasant ta/e & make x soluble 9 wat]1 milk1 c(fee1 & tea4 ,?is prep>ation 0 report$ on favorably by ,s*]]1#aad :o ass]ts t he obta9$ positive results 9 fifty-f\r ( ! eighty cases 9 :i* he us$ x4 #aab ,gillet-,damotti3 ,comp4 r5d4 ,acad4 d4 ,sc41 ,july #g1 #ahgc4 #aac ,fragn]3 ,wi54 m$4 ,w*ns*r4 #fj3ajcc-ajcf1 #aiaj4 #aad ,s*]]3 ,wi54 m$4 ,w*ns*r4 #fj3ajcc-ajcf1 #aiaj4 ,m rec5tly ,hut#aae te/$ ! effects ( ,!9h>dt's ,hygiama lactog5e on f\r lactat+ wom54 ,?is prep>ation is said to be compos$ ( hygiama1#aaf galega & anise4 ,analysis %[$ t x conta9s album9s1 fat1 soluble & insoluble c>bohydrates1 salts & wat]4 ,hut c\ld n obs]ve any influ5ce f ! use ( ?is prep>ation1 ei!r on ! quantity or on ! composition ( ! milk secret$4 #aae ,hut3 ,n$]l&s* ,tijds*r4 v4 ,g5eesk4 #a3acec-acgj1 #aiad4 #aaf ,hygiama is said to be a food consi/+ ( cond5s$ milk1 ) 7fatless7 cocoa & c]eals add$ to x 7,encyclop$ia & ,diction>y ( ,m$ic9e & ,surg]y1 #aijg74 ,nutrolactis#aag is a comm]cial prep>ation sold by ! ,nutrolactis ,company ( ,new ,york at #a a bottle4 ,! label /ates t x conta9s #e p] c5t4 ( alcohol2 t x conta9s fluid extracts ( ! family ( 8galactagogic plants10 & t x is int5d$ to 8increase ! supply ( "m's milk40 ,x is recomm5d$ to ma9ta9 8quality & quantity until ! end ( normal lactation40 ,nutrolactis is also recomm5d$ = a "m debilitat$ by lactation4 ,x is claim$ t 8,nutrolactis does n =ce ! secretion ( milk b m]ely assi/s su* secretion40 ,ye>s ago ,millbank#aah report$ good results f ! use ( ,nutrolactis4 ,aft] m ?an a ye>'s use he conclud$ t x 0 m satisfactory ?an any o!r lactagogue hi!rto employ$ by him1 :i* is n say+ v mu*1 z specific lactagogues are z yet unkn[n4 ,nutrolactis is /ill 7#aiaf7 ext5sively adv]tis$ 9 v>i\s m$ical j\rnals z a lactagogue4 #aag ,! ,nor? ,dakota ,agricultural ,exp]im5t ,/ation has rec5tly publi%$ 7,bullet9 #bb1 #aiae1 p4 #chf7 a complete *emical analysis ( ,nutrolactis4 ,x conta9s only #j4fj p] c5t4 solids 7includ+ /ry*n9 & emod974 ,x has a bitt] ta/e4 ,! alcohol cont5t 0 #c4e p] c5t4 ,! report concludes3 8a little /ry*n91 a little alcohol1 & a little laxative is ab\t all !re is to cause an increase 9 ! milk secretion40 #aah ,millbank3 ,new ,york ,m4 ,j4 #ej3edd1 #ahhi4 ,,me?ods ,,( ,,inve/igation ,! alleg$ lactagogue action ( galega & ,nutrolactis 0 te/$ on lactat+ dogs & goats4 ,9 ^! animals ! psy*ic factors1 or sugge/ion1 are l>gely elim9at$4 ,if ! results _h be5 positive or _h indicat$ lactagogue action1 ! te/ w\ld h be5 ext5d$ to nurs+ wom54 ,! puppies & kids 7 weigh$ be=e & aft] nurs+ & a record kept ( ! am\nt ( milk obta9$ at ea* nurs+ 7! animals nurs+ f ?ree to five times daily74 ,! mo!rs 7 f$ ) v>y+ doses ( ! drugs1 & ! milk yield comp>$ ) t ( a control p]iod dur+ :i* no drugs 7 adm9i/]$4 ,an ef=t 0 made to keep ! conditions ( ! exp]im5ts uni=m ?r\gh\t4 ,! galega 0 gr\nd & mix$ ) ! food4 ,! ,nutrolactis 0 mix$ ) food giv5 by ! /oma* tube1 or 9 "s cases ) a spoon4 ,galega 0 te/$ on two goats & ,nutrolactis on "o goat & n9e dogs4 ,! results are giv5 h]e)3 ,,galega ,goat #a3 ,control p]iod1 #a1fjj gm41 milk av4 daily yield = #g days4 ,galega p]iod 7#cj gm4 galega mix$ ) oats71 #hfj gm41 milk av4 daily yield = #h days4 ,kids wean$ at end ( p]iod4 ,goat #b3 ,control p]iod1 #a1afa gm4 milk av4 daily yield = #i days4 ,galega p]iod 7#cj gm4 galega mix$ ) oats71 #hfj gm4 milk av4 daily yield = #h days4 7#be gm4 galega 9 same way71 #haj gm4 milk av4 daily yield = #aj days4 ,control p]iod1 #hif gm4 milk av4 daily yield = #f days4 ,,nutrolactis ,goat #c3 ,control p]iod1 #hif gm4 milk av4 daily yield = #f days4 ,nutrolactis p]iod 7#cj c4c4 ,nutrolactis mix$ ) oats71 #feh gm4 milk av4 daily yield = #i days4 ,control p]iod1 #fff gm4 milk av4 daily yield = #e days4 ,dog #a3 ,control p]iod1 #agf gm4 milk av4 daily yield = #g days4 ,nutrolactis p]iod 7#h c4c4 ,nutrolactis by /oma* tube71 #ee gm4 milk av4 daily yield = #ab days4 ,dog #b3 ,control p]iod1 #ahi gm4 milk av4 daily yield = #f days4 ,nutrolactis p]iod 7#h c4c4 ,nutrolactis by /oma* tube71 #gb gm4 milk av4 daily yield = #aa days4 ,dog #c3 ,control p]iod1 #ic gm4 milk av4 daily yield = #h days4 ,nutrolactis p]iod 7#h c4c4 ,nutrolactis on bread71 #ag gm4 milk av4 daily yield = #e days4 ,dog #d3 ,control p]iod1 #bh gm4 milk av4 daily yield = #g days4 ,nutrolactis p]iod 7#h c4c4 ,nutrolactis by /oma* tube71 #dg gm4 milk av4 daily yield = #f days4 7#aj c4c4 ,nutrolactis by /oma* tube71 #dc gm4 milk av4 daily yield = #h days4 ,control p]iod1 #da4e gm4 milk av4 daily yield = #f days4 ,nutrolactis p]iod 7#aj c4c4 ,nutrolactis by /oma* tube71 #cc4e gm4 milk av4 daily yield = #d days4 ,dog #e3 ,control p]iod1 #fg gm4 milk av4 daily yield = #f days4 ,nutrolactis p]iod 7#aj c4c4 ,nutrolactis on bread71 #ha gm4 milk av4 daily yield = #f days4 ,dog #f3 ,control p]iod1 #dj gm4 milk av4 daily yield = #e days4 ,nutrolactis p]iod 7#aj c4c4 ,nutrolactis by /oma* tube71 #cc gm4 milk av4 daily yield = #h days4 ,control p]iod1 #bf gm4 milk av4 daily yield = #d days4 ,dog #g3 ,control p]iod1 #bhc gm4 milk av4 daily yield = #i days4 ,nutrolactis p]iod 7#aj c4c4 ,nutrolactis by /oma* tube71 #aee gm4 milk av4 daily yield = #ae days4 7#ae c4c4 ,nutrolactis by /oma* tube71 #hb gm4 milk av4 daily yield = #f days4 ,control p]iod1 #cc gm4 milk av4 daily yield = #c days4 ,dog #h3 ,control p]iod1 #bch gm4 milk av4 daily yield = #h days4 ,nutrolactis p]iod 7#bj c4c4 ,nutrolactis on bread71 #bbc gm4 milk av4 daily yield = #d days4 7#bj c4c4 ,nutrolactis on bread71 #df gm4 milk av4 daily yield = #f days4 ,dog #i3 ,control p]iod1 #bbc gm4 milk av4 daily yield = #f days4 ,nutrolactis p]iod 7#aj c4c4 ,nutrolactis on bread71 #agh gm4 milk av4 daily yield = #ae days4 7#ae c4c4 ,nutrolactis on bread71 #adf gm4 milk av4 daily yield = #e days4 ,,comm5t ,,& ,,conclusion ,goat #a _h already be5 lactat+ = ov] two mon?s1 & ! yield 0 gradually decreas+ at ! "t ! obs]vations 7 begun4 ,! adm9i/ration ( galega did n *eck ?is decrease4 ,goat #b %\ld h be5 a v favorable subject1 = ! kid 0 ab\t a week old at ! "t ! obs]vations 7 begun4 ,bo? galega & ,nutrolactis caus$ a decrease 9 milk yield ( ?is animal4 ,?is decrease is p]haps p>tly due to ! animal's di/a/e = ! drugs & h] consequ5t failure to eat z well z dur+ ! control p]iods4 ,adm9i/ration ( ,nutrolactis 0 accompani$ by an increase 9 milk 9 only two animals1 ,dog #d & ,dog #e4 ,a detail$ exam9ation ( ! records ( ^! two dogs %[s t 9 bo? cases !re 0 a progressive increase 9 milk yield dur+ ! control p]iod & t adm9i/ration ( ! drug fail$ to accel]ate ?is increase4 ,on ! contr>y1 ! curve = ,dog #e takes a sudd5 drop imm$iately aft] ! fir/ adm9i/ration ( ! drug4 ,! records ( ,dogs #f & #g %[ t ! yield dur+ ! second control p]iod is l[] ?an t ( ! prec$+ p]iods4 ,al?\gh ! adm9i/ration ( ! drug 9 bo? cases 0 foll[$ by a decrease 9 ! yield1 x may be urg$ t ! drug has "s lactagogue action1 = its discont9uance 0 foll[$ by a decrease 9 yield4 ,?is effect1 h[ev]1 is also app>5t r ?an real1 = ! data %[ a gradual fall+ (f 9 yield dur+ ! p]iod ( adm9i/ration ( ! drug1 :i* decrease 0 n accel]at$ by )draw+ ! drug4 ,our data %[ t galega & ,nutrolactis1 :5 tak5 by m\?1 & ! elem5ts ( sugge/ion exclud$1 _h no b5eficial effect on lactation--at lea/ 9 s f> z ! quantity ( milk is conc]n$4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,may #bf1 #aiag47 ,,! ,,russell ,,emulsion ,,& ,,! ,,russell ,,prep>$ ,,gre5 ,,bone ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! foll[+ report on 8,! ,russell ,emulsion0 & 8,! ,russell ,prep>$ ,gre5 ,bone10 m>ket$ by ! ,/&>d ,emulsion ,company1 0 submitt$ to ! ,c\ncil by a ref]ee4 ,! ,c\ncil endors$ ! report & au?oriz$ its publication4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,! ,russell ,emulsion is put up 9 a neat package & adv]tis$ 9 an attractive pamphlet1 on ! cov] ( :i* we are told3 8,tru? ,always ,ju/ifies ,! ,sup]lative ,degree40 ,z :at foll[s 9 ! booklet & 9 ! pr9t$ circul>s c]ta9ly does n lack sup]latives1 ?is is d\btless a w>n+4 ,9 addition to ! pamphlet & circul> adv]tis+1 ! product seems to be sy/ematically boom$ by a lecture s*eme 9 :i* "o ,dr4 ,hague talks be=e m$ical societies & di/ributes adv]tis+ matt]4 ,! lecture is succe$$ by a foll[-up lett] s*eme ?r\gh :i* matt] is s5t to memb]s ( ! society4 ,hague o/5sibly discusses 8lime />vation 9 tub]culosis10 b m$ical societies soon le>n$ to e/imate 8 "w z ess5tially to adv]tise ! ,russell products4 ,la/ ,april ! ,m$ical ,society ( ! ,/ate ( ,p5nsylvania s5t out a circul> lett] to its c\nty organizations on ! subject ( ! ,russell-,hague propag&a :i* op5s 9 ?is way3 8,y h d\btless receiv$ a lett] f ,dr4 ,william ,grant ,hague ( ,new ,york1 (f]+ to address y\r c\nty society on ,tub]culosis4 ,aft] due inve/igation1 x is respectfully sugge/$ t x may n be desirable to ask him to address y\r society44440 ,! /atem5ts 9 ! pamphlet & circul> publi%$ are typical ( ! :ole me?od ( exploitation4 ,= example1 c su* claims z ^! be surpass$ by ! v]ie/ quack8 8,,sci5ce _c improve ! means employ$ 9 produc+ ,,! ,,russell ,,emulsion40 8,,g5ius has n devis$ bett] me?ods ?an are us$ 9 manufactur+ ,,! ,,russell ,,emulsion40 8,,money _c buy bett] products ?an are us$ 9 ,,! ,,russell ,,emulsion40 8,,exp]i5ce _c sugge/ a m nutriti\s comb9ation ( fats ?an we use 9 ,,! ,,russell ,,emulsion40 ,! emulsion is said to be made ( equal p>ts ( beef-fat1 coconut1 peanut & cottonse$ oils1 held 9 susp5sion by album94 ,! latt] we are told is appli$ to ea* globule ( ! emulsion by an 8elaborate te*nical process0 devis$ by ,dr4 ,russell4 ,! mixture is ev]y:]e spok5 ( z a 8physiological0 emulsion1 b ! ^w is always 9 quotation m>ks4 ,:y x is call$ 8physiological0 is n cle>1 b ! t]m may be c\nt$ on to impress ! un?9k+ or ! unsci5tific4 ,num]\s false & exagg]at$ /atem5ts are made ab\t ?is 8physiological0 emulsion ) ref]5ce to food value4 ,= in/ance3 8,! nutritional value ( fats diff]2 ! nutritional value ( ^! fats & _! increas$ effici5cy by comb9ation ov] all o!rs h be5 det]m9$ by ext5sive cl9ical obs]vation40 ,& also3 8,! ,russell ,emulsion is approximat$ 9 food value by no o!r emulsion or food product 9 exi/5ce40 8,a #8physiological' emulsion is a pr$ige/$ food4 ,x is absorb$ ) little assi/ance f ! dige/ive juices1 & ) no wa/e ( en]gy4 ,x is1 !re=e1 ! ideal food44440 ,^! are sample /atem5ts f\nd 9 ! pamphlet & accompany+ circul>4 ,a doz5 or m pa?ologic conditions are m5tion$ 9 :i* ?is 8ideal food0 is specifically indicat$2 b we f9d1 also1 ?is curi\s /atem5t3 8,pati5ts c r>ely take ?is dose speak+ ( ! maximum dose ( #b ounces night & morn+ = m ?an ?ree or f\r weeks )\t %[+ symptoms ( ov]-fe$+40 ,?is ungu>d$ rem>k ab\t an +e/ion ( #dh grams ( fat daily prompts "o to ask :at is wrong ) ! 8ideal pr$ige/$ food40 ,russell is w$d$ to ! idea t 8lime />vation0 is ! ma9 factor 9 tub]culosis1 & insi/s on ! importance ( l>ge am\nts ( fat = ! 8lime />v$40 8,dr4 ,russell 0 ! orig9al int]pret] ( ! ,lime ,/>v$ ,/ate & orig9at$ ,! ,lime ,/>vation ,treatm5t 9 ,tub]culosis4 ,he also fir/ po9t$ out & emphasiz$ ! !rapeutic importance ( reg>d+ ! comb9ation ( lime phosphate & case91 z br\ght d[n by ! r5net enzyme1 z a *emical union40 ,?is ov]work$ lime-/>vation !ory c]ta9ly lacks any tangible confirmation 7see 9 ?is connection a rec5t pap] by ,halv]son1 ,mohl] & ,b]geim1 9 ,! ,j\rnal1 ,may #e1 #aiag71 & to urge x to promote ! sale ( a fat prep>ation is prepo/]\s4 ,on ! un9itiat$ ! exagg]at$ pseudo-sci5tific language ( ! pamphlet & circul> adv]tisem5t w probably make "s impression4 ,un=tunately su* ?+s c\nt n only ) ! layman :o1 hav+ no te*nical k ( physiology1 _c be expect$ to weigh ! evid5ce b also ) ^? m$ical m5 :o1 :ile sci5tifically educat$1 are influ5c$ by unsci5tific claims :5 plausibly pres5t$4 ,! pamphlet is a /rik+ example ( a /yle :i* is dang]\s because x smacks ( sci5ce4 ,! ,russell ,company sells also a mixture call$ 8,prep>$ ,gre5 ,bone10 said to be made by p>tially dige/+ gr\nd *ick5 bones ) hydro*loric acid & peps9 & add+ glyc]9 at ! end ( ! dige/ion4 ,! product is a /icky1 unappetiz+ look+ mass1 put up 9 little e>!nw>e boxes & adv]tis$ z a lime food1 app>5tly to g along ) ! fat emulsion4 ,! great] value ( a few glasses ( milk daily is evid5tly ov]look$4 8,! ,russell ,emulsion0 & 8,! ,prep>$ ,gre5 ,bone0 7 decl>$ inadmissible to ,new & ,non(ficial ,rem$ies4 ,editorial ,comm5t4--,!re are always ^? :o are ready to exploit ! un=tunate tub]cul\s4 ,x is1 un=tunately1 a fact t _m physicians accept z true1 /atem5ts clo!d ) obscure & volum9\s quasi-sci5tific v]biage4 ,su* m5 w\ld laugh at ! bald claim t ! moon is made ( gre5 *eese2 :51 h[ev]1 "o plausibly & ) due solemnity1 affirms t ! nocturnal lum9\s e>?ly satellite is compos$ ( an inf9ite aggregation ( molecules ( bewild]+ & awe-compell+ complexity1 built up f ! rec5tly discov]$ polypeptids1 ! :ole be+ ( a v]dant t9t1 ! p]son address$ looks impress$ & op9es t x s\nds reasonable6 ,! adv]tis+ = ,! ,russell ,emulsion & ,! ,russell ,prep>$ ,gre5 ,bone is dang]\s because x appeals to ! ?\ghtless--layman & physician1 alike4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,june #bc1 #aiag47 ,,brom-,i-,,phos ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,brom-,i-,phos 7,national ,drug ,company1 ,philadelphia7 0 submitt$ to ! ,c\ncil ) a label be>+ ! foll[+ /atem5t3 8#8,,alcohol #be ,,p] ,,c5t4' ,,composition--,p] ,fluid\nce ,iod9 #a gr4 ,brom9 #a gr4 ,phosphorus #h-ajj gr4 ,aromatic ,base q4 s40 ,a reque/ = fur!r in=mation 9 reg>d to ! composition ( ,brom-,i-,phos 0 s5t to ! ,national ,drug ,company4 ,x 0 sugge/$ t s9ce ! prep>ation _c conta9 ! /at$ am\nts ( free brom91 free iod9 & free phosphorus1 ! =m ( comb9ation 9 :i* ^! elem5ts are pres5t %\ld be set =?4 ,9 reply1 ! firm said1 fir/1 t 8,brom-,i-,phos consi/s ( ,brom91 ,iod91 ,phosphorus1 ,glyc]91 ,w9e1 ,wat] & ,volatile ,oils4 ,! ,iod9 is rubb$ up ) a small p]c5tage ( ,potassium ,iodid & #ie p] c5t4 ,alcohol1 :i* solution is mix$ ) a solution ( ,brom9e & ,spirits ( ,phosphorus :i* are comb9$ ) ! base & aromatics40 ,! manufactur] also admitt$ t phosphorus reacts ) brom9 & iod9 & t o!r reactions might occur1 b ma9ta9$ t x 0 8ju/ifi$ 9 assum+ ! great] "p1 if n all ( ^! elem5ts1 are actually exi/5t 9 ! nasc5t /ate10 & ass]t$ t its 8pr9t$ =mula complies ) our work+ =mula 9 po9t ( quantities involv$ z well z exi/5ce ( elem5ts 9 an uncomb9$ /ate40 ,! ,a4 ,m4 ,a4 ,*emical ,laboratory report$1 on ! contr>y1 t no free phosphorus1 free brom9 or free iod9 c\ld be f\nd 9 ,brom-,i-,phos1 & t no bromate or iodate c\ld be f\nd2 bromid & iodid 7 pres5t4 ,! addition ( silv] nitrate to an acidulat$ portion1 dilut$ ) wat]1 gave an am\nt ( silv] halid r\ghly agree+ ) t :i* w\ld be obta9$ _h ! claim$ am\nt ( brom9 & iod9 7toge!r ) "s potassium iodid7 be5 us$ 9 ! prep>ation ( ,brom-,i-,phos & 9 ! process ( manufacture become conv]t$ to bromid & iodid4 ,! ,c\ncil decl>$ ,brom-,i-,phos inadmissible to ,new & ,non(ficial ,rem$ies1 = conflict ) ,rules #a1 #d1 #f1 #h & #aj4 ,! /atem5t ( composition is unsatisfactory & mislead+ 9 t x sugge/s t ! prep>ation conta9s brom91 iod9 & phosphorus 9 ! free 7elem5t>y7 /ate4 ,! pres5ce ( ! pot5t elem5t>y phosphorus is especially sugge/$ by ! small am\nts ( 8phosphorus0 decl>$4 ,! foll[+ /atem5t on ! label ( ! trade package con/itutes an indirect adv]tisem5t to ! public3 8,,indications3 ,scr(ula1 ,coryza1 ,hay ,fev] ,necrosis1 ,bron*ial & ,?roat ,affections1 ,cat>rhal ,pneumonia1 ,gl&ul> enl>gem5ts ( ! ,sple51 ,?yroid1 & ,lymphatics1 ,rickets & ,syphilis40 ,! foll[+ claims are !rapeutic exagg]ations3 8,! ,ideal ,alt]ative0 8444 indicat$ 9 all cases :]e an alt]ative is desir$ 4440 8,! association ( ,brom9 ) ,iod9 9 ,brom-,i-,phos mat]ially enhances ! product 9 ! treatm5t ( *ronic affections ( ! sk91 deprav$ conditions ( ! muc\s membranes1 t]ti>y syphilis1 gl&ul> enl>gem5ts1 etc40 ,9 t x sugge/s t ! phosphorus 9 ,brom-,i-,phos is m readily assimilat$ ?an ord9>y phosphate1 ! foll[+ is mislead+3 8,! ,phosphorus conta9$ 9 ,brom-,i-,phos is readily assimilat$ & at once acts z a nutri5t to ! n]v\s & osse\s /ructures ( ! body1 /imulates metabolism & increases m5tal activity40 ,! recomm5dation3 8,y\r specification ( ,brom-,i-,phos 9 ! treatm5t ( ,syphilitic cases w imm$iately prove b5eficial to ! pati5t0 is n support$ by evid5ce4 ,! "n does n indicate t ,brom-,i-,phos is an alcoholic prep>ation ) iodid z its ess5tial con/itu5t1 b sugge/s t phosphorus is an important con/itu5t1 :]eas ! am\nt ( phosphate or phosphite1 produc$ by ! action ( iod9 on elem5t>y phosphorus 7if ! am\nt ( phosphorus us$ 9 mak+ ! prep>ation is correctly /at$7 is insignificant4 ,! comb9ation ( brom91 iod9 & phosphorus1 or bromid1 iodid & phosphate1 is irrational because ^! elem5ts are n ( mutual assi/ance to ea* o!r 9 ! conditions = :i* ,brom-,i-,phos is adv]tis$4 ,! ,c\ncil's report 0 submitt$ to ! manufactur] ( ,brom-,i-,phos = comm5t2 ! reply conta9$ no?+ to p]mit a revision ( ! previ\s conclusions4 ,! ,c\ncil decl>$ ,brom-,i-,phos inadmissible to ,new & ,non(ficial ,rem$ies4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,june #cj1 #aiag47 ,,creosote-,,delson ,,& ,,cre(os ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,creosote-,delson & ,cre(os1 or ,creosote ) ,hypophosphites1 7 submitt$ by ! ,delson ,*emical ,co41 ,inc41 ,new ,york ,city4 ,creosote-,delson is said to be 8bee*wood creosote f :i* ! irritat+ & cau/ic prop]ties are remov$ by fractional di/illation40 ,x is claim$ t ,cre(os conta9s 8#b gra9s ( ,creosote-,delson & #c-c_/e gra9s ( ! comb9$ ,hypophosphites 9 ea* fluidra*m ( ! mixture or emulsion1 ! lime salt pr$om9at+40 ,x is also claim$ t 8! prim>y object ( ! hypophosphites 9 ?is prep>ation is t ( ma9ta9+ ! ref9$ creosote 9 a pure1 unoxidiz$ /ate1 & t no p>ticul> claim = !rapeutic action on _! "p is advanc$40 ,x is expla9$ fur!r1 h[ev]1 8! addition ( ! lime 0 prompt$ by ! belief 444 t ! fundam5tal cause ( pulmon>y tub]culosis is lime />vation44440 ,! ass]tions are made t ,creosote-,delson is sup]ior to ! (ficial creosote because x c be tak5 8abundantly & p]si/5tly )\t h>m to or int]f]5ce ) /oma* & kidneys0 & c be 8tak5 un9t]rupt$ly & indef9itely10 :ile ! dosage is 8unlimit$ by any =m] k ( ,creosote ,!rapy40 ,creosote-,delson is n on ! m>ket except 9 ! comb9ation ,cre(os1 al?\gh x is suppli$ on reque/4 ,cre(os is advis$ 9 ! treatm5t ( tub]culosis1 :oop+ c\gh1 measles1 8,grippe & ,colds10 bron*itis1 a/hma1 8,inte/9al ,affections 7,colitis1 ,summ] ,di>rhoea1 etc4710 :ile its use is sugge/$ = ! 8prev5tion ( ! spread ( contagi\s diseases10 & = 8prev5t+ contagion 9 m9or contagi\s diseases at any rate1 9 s*ools & families40 ,! foll[+ adv]tisem5t has rec5tly appe>$ 9 ! ,new ,york ,m$ical ,j\rnal & 9 ! ,!rapeutic ,gazette3 ,,cre(os ,,m$ication is ! successful developm5t ( ! mo/ advanc$ practice 9 ! treatm5t ( infecti\s diseases4 ,x de/roys completely ! causative organisms by a bact]icide _m times m p[]ful ?an ph5ol1 yet absolutely h>mless to animal life4 ,unlike s]ums1 its activity is n conf9$ to any specific disease1 & its use insures aga9/ sequelae 7z pneumonia foll[+ grippe74 ,especially valuable 9 ! treatm5t ( infants & pati5ts ( delicate con/itution & 9 cases :]e "t is ( importance4 ,! ,delson ,*emical ,co4 0 reque/$ to supply in=mation reg>d+ ! id5tity ( ,creosote-,delson & to support ! claim t al?\gh x is 8! :ole drug0 its dosage is 8unlimit$ by any =m] k ( ,creosote ,!rapy40 ,! reply 0 virtually an admission t ! toxic1 cau/ic1 ph5olic compon5ts ( creosote 7 pres5t 9 ,creosote-,delson j z 9 ! (ficial creosote4 ,! ref]ee ( ! ,committee on ,!rapeutics 9 submitt+ 8 report to ! ,c\ncil po9t$ out t x is difficult to discuss ! ph>macologic m]its ( a semisecret prep>ation1 l ,creosote-,delson1 claim$ to be m acceptable to ! human organism ?an ! (ficial product x is int5d$ to supplant1 :5 ! action ( ! p>5t drug is /ill que/ion$ or disput$ by em95t cl9icians4 ,absorption exp]im5ts h be5 c>ri$ out ) creosote & creosote comp\nds1 su* z creosote ) hypophosphites or calcium or creosote c>bonate1 *iefly by a /udy ( ! elim9ation products 9 ! ur9e4 ,b any evid5ce s f> (f]$ t ^! comb9ations increase absorption & less5 ! irritat+1 cau/ic or toxic prop]ties has be5 :olly inconclusive4 ,! evid5ce (f]$ by ! ,delson ,*emical ,co4 pres5t$ no control exp]im5ts ) ! (ficial creosote & did n prove t ei!r ,creosote-,delson or ,cre(os 0 less toxic ?an a correspond+ am\nt ( ord9>y bee*wood creosote4 ,! ref]ee conclud$ t no pro( _h be5 (f]$ t ^! prep>ations are mat]ially sup]ior to ord9>y creosote prep>ations f ! ph>macologic or !rapeutic /&po9t1 & t ! claims made = ,creosote-,delson & ,cre(os are unw>rant$ 9 ! light ( our k ( ! prop]ties ( creosote4 ,! adv]tisem5t quot$ above is an example ( unprov$ & unw>rant$ claims4 ,on ! recomm5dation ( ! ref]ee1 ! ,c\ncil decl>$ ,creosote-,delson & ,cre(os inadmissible to ,new & ,non(ficial ,rem$ies1 = conflict ) ! rules z foll[s3 ,creosote-,delson3 ,! in=mation s f> available is n suffici5t to def9e ! nature1 or composition1 ( ,creosote-,delson1 or to indicate 9 h[ f> ?is product diff]s1 if at all1 f ! (ficial creosote 7conflict ) ,rule #a74 ,no me?ods are furni%$ = det]m9+ ! id5tity or composition ( ,creosote-,delson 7conflict ) ,rule #b74 ,! available in=mation does n %[ t ,creosote-,delson has advantages ov] creosote 7conflict ) ,rule #f74 ,cre(os3 ,! composition ( ,creosote-,delson n hav+ be5 furni%$1 ! /atem5t conc]n+ ! composition ( ,cre(os is also unsatisfactory 7conflict ) ,rule #a74 ,! !rapeutic claims are unsub/antiat$ & grossly exagg]at$ 7conflict ) ,rule #f74 ,! "n is n descriptive ( its composition z is requir$ = ph>maceutical mixtures 7conflict ) ,rule #h74 ,!re is no evid5ce t hypophosphites prev5t decomposition ( creosote 7if ?is occurs74 ,h5ce ! inclusion ( hypophosphites mu/ be consid]$ irrational 7conflict ) ,rule #aj74 ,! ,c\ncil's report 0 s5t to ! ,delson ,*emical ,co4 = consid]ation4 ,! firm's reply conta9$ no?+ to w>rant a revision ( ! report1 & ! ,c\ncil vot$ t ,creosote-,delson & ,cre(os 7 inadmissible to ,new & ,non(ficial ,rem$ies & au?oriz$ ! publication ( ?is report4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,july #g1 #aiag47 ,,tr9]',s ,,am]ican ,,elixir ,,( ,,bitt] ,,w9e ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,tr9]'s ,am]ican ,elixir ( ,bitt] ,w9e is a w9e to :i* bitt] drugs & laxatives h be5 add$4 ,?\gh evid5tly int5d$ = public consumption1 x is also adv]tis$ to physicians1 & consequ5tly ! ,c\ncil publi%es ?is report4 ,"s rec5t adv]tisem5ts read3 8,x ,acts ,well & ,is ,v ,palatable4 ,^! are ! reasons :y s _m physicians recomm5d ,,tr9]',s ,,am]ican ,,elixir ,,( ,,bitt] ,,w9e4 ,free f any *emicals4 ,prep>$ f bitt] h]bs roots & b>ks ( em95t m$ic9al value & pure natural r$ w9e4 ,a safe relief 9 auto-intoxication1 con/ipation1 weakness1 etc4 ,price #a4jj4 ,at drug ,/ores4 ,samples gratis ^u reque/ only to physicians40 8,a ,laxative ,tonic4 ,9 cases ( con/ipation & its sequel1 auto9toxication1 weakness & n]v\sness y %\ld try ,tr9]'s ,am]ican ,elixir ( ,bitt] ,w9e4 ,?is prep>ation consi/s ( ,casc>a ,sagrada1 ,d&elion1 ,g5tian ,root1 ) ,licorice 9 ,pure ,r$ ,w9e z a base1 ) ,aromatics40 ,tr9]'s ,am]ican ,elixir ( ,bitt] ,w9e is put up 9 bottles said to hold #a p9t1 #e-a_/c fluid\nces4 ,! label decl>es ! pres5ce ( f #af to #ah p] c5t4 alcohol by volume1 & /ates t 8no special tax is requir$ by ! laws ( ! ,u4 ,s4 = ! sale ( ?is m$ic9al prep>ation40 ,! circul> conta9s ! foll[+ recomm5dations = its use3 8444 ,x %\ld be us$ 9 all cases call+ = a safe evacuation ( ! b[els1 )\t weak5+ ! body or caus+ any pa9 or o!r discom=t2 9 loss ( appetite1 n]v\sness & weakness40 8,tr9]'s ,am]ican ,elixir ( ,bitt] ,w9e consi/s ( two pr9cipal +r$i5ts1 viz41 ,r$ ,w9e & ,m$ic9al ,h]bs40 8,r$ ,w9e /r5g!ns ! inte/9es & regulates _! "w4 ,x also increases ! appetite1 /imulates & /r5g!ns ! body40 8,use ,tr9]'s ,am]ican ,elixir ( ,bitt] ,w9e always :5 a ?or\gh clean+ out ( ! inte/9es is ne$$4 ,arrange ! dose to suit y\r condition & habits40 8,9 ,*ronic ,con/ipation ! dose ( ,tr9]'s ,am]ican ,elixir ( ,bitt] ,w9e %\ld be increas$ or tak5 (t5]40 8,_m ,female ,tr\bles are caus$ or aggravat$ by con/ipation & ladies %\ld always pay good att5tion to ?is fact40 ,9 addition to ,tr9]'s ,elixir ( ,bitt] ,w9e1 ! circul>--9 ,engli%1 ,poli%1 ,russian1 ,spani% & o!r languages--advises ! use ( ,tr9]'s ,angelica ,bitt] ,tonic1 ,tr9]'s ,r$ ,pills1 ,tr9]'s ,l9im5t & ,tr9]'s ,c\gh ,s$ative4 ,! composition ( ?is 8w9e0--"s bitt] drugs1 a laxative & a tann9-conta9+1 con/ipat+ r$ w9e--& adv]tis+ propag&a all t5d to ! cont9u$ use ( ?is alcoholic /imulant & ?us to ! unconsci\s =mation ( a desire = alcoholic /imulation4 ,z ! m$ical j\rnal adv]tisem5ts may lead physicians to prescribe ?is secret & irrational prep>ation & ?us unconsci\sly lead to alcoholism1 ! ,c\ncil au?oriz$ publication ( ?is report4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,july #ad1 #aiag47 ,,trime?ol ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,trime?ol is ! trade "n = a sub/ance said to be trime?yl-me?oxy-ph5ol ( ! =mula ,c,h7,,*77,,o*74,,oh--#a3b3d3e3f1 orig9at$ by ,j4 ,t4 ,a9slie ,walk]4 ,x is sold z a nontoxic g]micide1 hav+ a ,rideal-,walk] ph5ol-coeffici5t ( #dj1 ev5 9 ! inte/9al canal4 ,x is describ$ z insoluble 9 wat] & n to be decompos$ 9 ! alim5t>y tract1 & to be excret$ un*ang$ 9 ! feces4 ,trime?ol itself is n obta9able4 ,ph>maceutical prep>ations--,trime?ol ,syrup1 ,trime?ol ,capsules & ,trime?ol ,tablets1 said to conta9 ,trime?ol--are prep>$ by ,! ,walk]-,leem+ ,laboratories & sold by ,?os4 ,leem+ & ,co41 ,new ,york4 ,trime?ol prep>ations are adv]tis$ = use 9 all conditions dep5d5t on inte/9al putrefaction4 ,! adv]tis+ claims made are v ext5sive & "s ( !m give to 8,trime?ol0 ! scope ( a panacea4 ,= example3 8,physicians are con/antly report+ cases :]e ,trime?ol has be5 especially effici5t1 & describ+ conditions 7until rec5tly n associat$ ) inte/9al infection7 :i* h be5 di/9ctly b5efit$ by its use4 ,?is w\ld seem to be> out ! cont5tions ( ,*>cot & ,met*nik(f t #ij ( all human ailm5ts h _! orig9 9 inte/9al infection4 8,! c>eful practition]1 :5 9 d\bt1 w be> ?is 9 m9d1 n[ t we h a really effici5t & non-toxic inte/9al g]micide--n a m]e antiseptic40 ,! ,walk]-,leem+ ,laboratories h n =mally reque/$ ! ,c\ncil to consid] ! ,trime?ol prep>ations1 ?\gh 9 a p]sonal lett] to a memb] ( ! ,c\ncil ,j4 ,t4 ,a9slie ,walk] invit$ an inve/igation ( 8 comp\nd4 ,= ! inve/igation ( ,trime?ol & its prep>ation ! ,c\ncil secur$ ! aid ( a bact]iologi/ :o has giv5 mu* att5tion to ! /udy ( ! inte/9al flora4 ,! ,walk]-,leem+ ,laboratories & ,j4 ,t4 ,a9slie ,walk] 7 bo? ask$ to submit details ( exp]im5tal /udies & also to furni% a supply ( ! pure 8,trime?ol40 ,b ! only data s5t t _h any def9it5ess set =? ! bact]ial c\nts made ( plate cultures ( /ools ( "o pati5t be=e & aft] ! adm9i/ration ( ,trime?ol ,capsules4 ,,refuse ,,to ,,furni% ,,trime?ol ,! reque/ = ! pure sub/ance 0 refus$1 on ! gr\nds t ! sub/ance 0 n us$ 9 ! undilut$ =m4 ,! failure to furni% ! *emical sub/ance claim$ z ! ess5tial con/itu5t ( ! ,trime?ol prep>ations is to be deprecat$ if inde$ x has n great] significance4 ,at lea/ x made x impossible = ! ,c\ncil's exp]t to express 8 results 9 t]ms ( absolute ,trime?ol ( e/abli%$ composition4 ,! data obta9$ apply only to ! m>ket prep>ations claim$ to conta9 ,trime?ol4 ,s f> z ! inve/igation & report g1 8,trime?ol0 is a hypo!tical sub/ance4 ,cl9ical or animal te/s ( ! ass]t$ inte/9al antiseptics h hi!rto giv5 equivocal results because x is impossible1 on ! "o h&1 to pr$ict ! c\rse ( any inte/9al infection1 or1 on ! o!r h&1 to det]m9e :at effect1 if any1 0 produc$ by adm9i/ration ( ! m$icam5t4 ,x !re=e seem$ unwise to und]take ?is l9e ( inve/igation until ! m direct laboratory bact]iologic me?ods _h be5 exhau/$4 ,consequ5tly ! inve/igator *eck$1 9 ! fir/ place1 ! ph5ol coeffici5t ( "o ( ! ,trime?ol prep>ations & !n also det]m9$ its 8p5etrability0 coeffici5t4 ,al?\gh by bo? me?ods ,trime?ol 0 f\nd to be a g]micide1 ! results did n indicate any rem>kable pot5cy or o!r prop]ties sugge/+ t ! drug possess$ special !rapeutic value4 ,f ! results obta9$ x appe>$ inadvisable to proce$ fur!r ) ! "w until m def9ite evid5ce ( ! nature & ( ! value ( ! sub/ance %\ld be at h&4 ,! report ( ! bact]iologic inve/igation foll[s3 ,,! ,,bact]iologi/',s ,,report 8,i h made no attempt to /udy ! effects ( int]nal adm9i/ration ( ,trime?ol on ! inte/9al flora4 ,! me?ods available at ! pres5t "t ( enum]at+ ! numb]s ( viable bact]ia 9 ! feces are probably n accurate )9 #ajj p] c5t4 & ! precision ( su* det]m9ations is equally v>iable4 ,! physiologic factors involv$ are s complex t !y w\ld appe> to make a really valuable assay a "q ( _m mon?s' c>eful /udy4 ,if x 7 possible to adm9i/] kn[n am\nts ( ,trime?ol1 z su*1 ! problem might be wor? :ile2 inasmu* z ! available reactive sub/ance is n at pres5t quantitatively assayable1 ?is phase ( ! inve/igation b>ely seems practicable4 8#8,trime?ol ,syrup1' z su*1 appe>s to be ab\t #aj p] c5t4 z effici5t 9 its g]micidal value z c>bolic acid4 ,if ! assay1 #c_/d m4 ,trime?ol p] drm4 7z ! label indicates71 is correct1 ! sub/ance w\ld appe> to possess g]micidal m]it provid$ en\gh c\ld be adm9i/]$1 if x is n influ5c$ by passage ?r\gh ! /oma*4 8,a package conta9+ f\r f\r-ounce bottles label$ #8,trime?ol1 ,a ,non-,toxic ,g]micide ,,syrup ,repres5t+ #c_/d m4 ,trime?ol p] drm41 ,alcohol #a-a_/b p] c5t4' 0 receiv$ at ! laboratory ,dec4 #ae1 #aiaf4 ,lat] a small] package conta9+1 accord+ to ! label1 #ajj ,trime?ol tablets1 ea* #e gr41 repres5t+ #a-a_/d m4 ,trime?ol1 0 receiv$4 ,! tablets 7 app>5tly *ocolate coat$4 8,two sep>ate s]ies ( te/s 7 made ^u ! syrup4 7a7 ,,ph5ol ,,coeffici5t1 us+ ! me?od outl9$ 9 ,bullet9 ,no4 #hb1 ,hygi5ic ,laboratory1 ,me?od ( ,/&>diz+ ,dis9fectants ,) & ,)\t ,organic ,matt]4 7b7 ,a ,,p5etrability ,,coeffici5t by ! me?od ( ,k5dall & ,edw>ds1 ,j\rnal ( ,infecti\s ,diseases1 #h1 #bej4 8,! =m] me?od comp>es ! viability ( nak$ g]ms 9 a #a p] c5t4 c>bolic acid solution z a /&>d1 ) v>i\s dilutions ( ! g]micide to be te/$4 ,! latt] measures ! relative diffusibility & g]micidal p[] ( c>bolic acid & v>i\s dilutions ( ! g]micide to be te/$ ^u ,bacillus coli susp5d$ 9 #a4b p] c5t4 ag> :i* is mold$ 9 cyl9d]s ( "o c5timet] diamet] aft] infection ) ! organism4 8,! fir/ me?od--ph5ol coeffici5t--possesses advantages & disadvantages :i* are well kn[n & ne$ no m5tion "h4 ,x is wor?y ( notice1 h[ev]1 t z ! dea? rate ( ! bact]ia increases dur+ ! progress ( ! te/1 x becomes increas+ly difficult to ma9ta9 a uni=m susp5sion ( liv+ organisms s t ea* loopful remov$ %all exactly repres5t ! developm5tal pot5tiality ( ! residual organisms4 8,! second me?od !oretically cov]s ! possibility because all ! organisms are immobiliz$ & are expos$ to ! g]micide 9 direct proportion to its diffusibility until ! c5t] ( ! ag> mass is rea*$1 :]e ! residual viable bact]ia are presumably locat$4 ,inasmu* z ! p5etrability ( an inte/9al mass is involv$ 9 a discussion ( inte/9al g]micides1 ! propriety ( utiliz+ ?is #8p5etrability coeffici5t' 9 ?is connection is obvi\s1 9 spite ( its pat5t %ortcom+s4 8,x is unnecess>y to discuss ! te*nique--! /&>d bro? m5tion$ 9 ! ,hygi5ic ,bullet91 a temp]ature ( #gj ,f41 a /&>d #d mm4 loop & c>eful att5tion to dilutions 7us+ di/ill$ wat]7 7 all obs]v$4 ,! v>i\s dilutions ( ,trime?ol ,syrup 7 made ) accurate volumetric pipettes1 measur+ flasks & di/ill$ wat] 0 us$ z a dilu5t4 8,! results ( sev]al det]m9ations1 us+ ,trime?ol ,syrup f ?ree sep>ate bottles1 7 9 suffici5t accord to w>rant ! /atem5t t a dilution ( #a_/aj ( ,trime?ol ,syrup 0 equival5t to a #a_/ajj dilution ( c>bolic acid1 us+ ,bacillus typhosus z ! te/ organism4 ,bo? solutions--! ,trime?ol & ph5ol--kill$ ! organism 9 ! int]val betwe5 #g-a_/b m9utes & #aj m9utes' exposure4 ,t is to say1 our obs]vations indicate t "u /&>d conditions z def9$ above1 a #aj p] c5t4 solution ( ,trime?ol ,syrup is equival5t 9 g]micidal p[]s1 z def9$ by ! ph5ol coeffici5t to a #a p] c5t4 solution ( ph5ol4 ,naturally1 no pr$ictions c be drawn f ^! obs]vations indicative ( ! value z an inte/9al g]micide ( ,trime?ol itself4 8,! ,,p5etrability ,,coeffici5t result$ z foll[s3 ,a #e p] c5t4 solution ( ph5ol kill$ ,bacillus coli1 susp5d$ uni=mly ?r\gh\t a cyl9d] ( #a4b p] c5t4 ag> 9 ! int]val betwe5 #fj & #ij m9utes4 ,a #a p] c5t4 solution ( ph5ol kill$ ! same organisms "u ! same conditions 9 ! int]val betwe5 two & "o half & ?ree h\rs4 ,an undilut$ solution ( ,trime?ol ,syrup kill$ ! organisms 9 ! int]val betwe5 two & "o half & ?ree h\rs4 ,a #aj p] c5t4 solution 7n9e volumes ( di/ill$ wat] to "o volume ( ,trime?ol ,syrup7 fail$ to kill ! organisms 9 f\r h\rs4 ,x w\ld appe> t undilut$ ,trime?ol ,syrup has ! same comb9$ p5etrability & g]micidal value z a #a p] c5t4 ph5ol solution4 8,! ,,ph5ol ,,coeffici5t3 ,a #aj p] c5t4 solution ( ,trime?ol ,syrup 9 di/ill$ wat] 7n9e volumes ( di/ill$ wat] to "o volume ( ,trime?ol ,syrup7 possesses ! same g]micidal p[] z a #a p] c5t4 solution ( c>bolic acid4 ,?is coeffici5t takes no cognizance ( ! actual am\nt ( ,trime?ol z su*--x m]ely indicates ! relative g]micidal p[] ( ! ,trime?ol ,syrup z sold40 ,! prec$+ report %[s t ,trime?ol ,syrup has a ph5ol coeffici5t ( #a_/aj1 &1 assum+ ,trime?ol ,syrup conta9s ! am\nt ( ,trime?ol decl>$1 ! sub/ance ,trime?ol w\ld h a ph5ol coeffici5t ( #h-a_/c in/ead ( #dj1 z is claim$4 ,accord+ to ,k5dall & ,edw>ds' me?od1 ! p5etrability-g]micidal value ( ! syrup is equal to a #a p] c5t4 solution ( ph5ol4 ,,walk]',s ,,reply ,,to ,,criticism ,! report ( ! bact]iologi/ 0 submitt$ to ,! ,walk]-,leem+ ,laboratories = comm5t4 ,! foll[+ reply 0 receiv$ f ,j4 ,t4 ,a9slie ,walk]3 7,may #bb1 #aiag7 8,9 reply to y\r lett] ( ! #ae? in/41 :i* has j be5 plac$ be=e me on my return to t[n1 ,i h to in=m y t ! pot5t con/itu5t ( ,trime?ol ,tablets & ,trime?ol ,syrup is n fully available z a bact]icide until x comes 9 contact ) ! pancreatic fluid4 8,z y w see f ! enclos$ extracts f cl9ical reports1 ! !rapeutic value ( ,trime?ol has be5 well e/abli%$4 8,z reg>ds p5etrability1 no claim has ev] be5 made = ,trime?ol 9 ?is connection2 &1 z ,i po9t$ out 9 my orig9al pap] 7,am]ican ,m$ic9e1 ,septemb]1 #aiad71 :5 ref]r+ to ! indep5d5t te/s made by ,dr4 ,fr$]ick ,sond]n1 #8,no attempt 0 made to det]m9e ! bact]ial cont5t ( ! solid p>ticles1 z 9 ! op9ion ( ! writ] /]ilization ( ! int]ior ( ^! p>ticles is n only absolutely impossible1 b :olly unnecess>y4 ,! fact ( ! fluid cont5ts ( ! canal be+ /]ile may be tak5 to indicate t ! ext]ior ( all solid p>ticles is 9 a l condition1 & !re=e h>mless4 ,x is ! organisms 9 ! fluid portions only t produce ! deadly effects ?r\gh ! *emical sub/ances !y secrete2 ^? 9 ! int]ior ( ! solid portions 7i4 e41 z evacuat$7 may be disreg>d$1 z !y are n available = good or evil4' 8,i mu/ confess to no little surprise on le>n+ t y\r inve/igator is /ill us+ ! ,hygi5ic ,laboratory me?od ( det]m9+ ph5ol coeffici5ts4 ,i w\ld respectfully sugge/ t y call 8 att5tion to ! critical comp>ison ( ! ,hygi5ic ,laboratory & ,r4-,w4 ,te/s1 :i* he w f9d 9 ! enclos$ repr9t f ! ,new ,york ,m$ical ,j\rnal ( ,m>* #aa1 #aiaf3 #8,in/ead ( be+ an improvem5t ^u ! /&>d ,r4-,w4 ,te/1 ! s-call$ ,hygi5ic ,laboratory ,me?od is s defective z to be :olly unreliable1 & incapable ( furni%+ results ( any sci5tific or practical value :atev]4'0 ,z to ! /atem5t t ! pot5t con/itu5t ( ,trime?ol ,tablets & ,trime?ol ,syrup is n fully available z a bact]icide until x comes 9 contact ) ! pancreatic fluid1 att5tion is call$ to a leaflet1 :i* accompanies ea* bottle ( ,trime?ol ,syrup1 t reads3 8,trime?ol is insoluble 9 wat]1 b :5 prop]ly emulsifi$ has a ,rideal-,walk] co-effici5t ( #dj2 t is to say1 x is #dj times m effici5t z a g]micide ?an ph5ol 7pure c>bolic acid740 ,! ,trime?ol ,syrup :i* 0 us$ 9 ! inve/igation1 :5 mix$ ) wat] produc$ an almo/ p]fectly transp>5t solution1 :i* ju/ifies ! assumption t ! prop] physical conditions 7 obs]v$ & t ?is objection is n well f\nd$4 ,z reg>ds ! relation ( pancreatic fluid to bact]icidal availability ( ,trime?ol1 !re is little to say1 o!r ?an t ! publi%$ /atem5ts 9 ! adv]tis+ accompany+ ! packages make no m5tion ( ?is po9t4 ,x w\ld be int]e/+ to "k :at1 if any1 relation ! pancreatic fluid has to ?is sub/ance1 9 view ( ! /atem5t t x 8has a ,rideal-,walk] coeffici5t ( #dj40 ,! ,trime?ol 8lit]ature0 does n ?r[ light on ! "q1 ,:at is ! g]micidal value ( ,trime?ol ,syrup z comp>$ ) ph5ol8 ,! only available me?od ( det]m9+ ! g]micidal value ( a liquid dis9fectant is to make a direct comp>ison ( ! sub/ance 9 "q ) ph5ol "u simil> conditions4 ,giv5 p>allel conditions1 n obvi\sly prejudicial to ! sub/ance te/$ 9 contra/ to ! /&>d solution1 ! results are comp>able1 & furni% a basis = e/imat+ ! relative g]micidal p[] ( ! two sub/ances4 ,9 ! inve/igation1 ,trime?ol ,syrup & ph5ol 7 ?us comp>$4 ,z reg>ds ! cont5tion t ! bact]ia )9 fecal masses are h>mless1 ?is may be grant$4 ,b x mu/ also be admitt$ t ^! inte/9al masses are con/antly be+ re=m$ s t buri$ micro-organisms d n rema9 9 ! int]ior4 ,= ?is reason1 ! det]m9ation ( ! p5etrability coeffici5t ( a g]micide is p]t95t4 ,reg>d+ ! respective m]its ( ! old ,rideal-,walk] & ! new] ,u4 ,s4 ,hygi5ic ,laboratory me?od ( det]m9+ ! ph5ol coeffici5t1 ! ,rideal-,walk] me?od 0 f\nd to possess c]ta9 drawbacks1 & 9 an attempt to ov]come ^! ! 8,lancet ,me?od0 0 evolv$2 ?is me?od 9 turn 0 improv$ 9 ! ,u4 ,s4 ,hygi5ic ,laboratory & l$ to ! ,unit$ ,/ates ,public ,heal? ,s]vice ,hygi5ic ,laboratory me?od = ! det]m9ation ( ! ph5ol coeffici5t ( dis9fectants 7publi%$ 9 ,hygi5ic ,laboratory ,bullet9 #hb74 ,9 #aiac ?is me?od 0 =mally adopt$ by ! ,c\ncil = ! valuation ( dis9fectants or g]micides ( ! ph5ol type1 & ! me?od is n[ 9 g5]al use = ?is purpose 9 ! ,unit$ ,/ates4#aai ,9 ?is connection ,hiss & ,z9ss] may be quot$ 7,ed4 #b1 page #hj73 8,! mo/ precise me?od ( /&>diz+ dis9fectants is t n[ 9 use 9 ! ,unit$ ,/ates ,public ,heal? ,s]vice40 ,/itt1 director ( ! ,unit$ ,/ates ,naval ,m$ical ,s*ools1 9 8 ,practical ,bact]iology1 ,blood ,"w & ,p>asitology 7,ed4 #d1 page #dgc7 says3 8,9 ! ,unit$ ,/ates dis9fectants are rat$ accord+ to ! ,hygi5ic ,laboratory ,ph5ol ,coeffici5t40 #aai ,^? :o are int]e/$ 9 ! relative m]its ( ! ,rideal-,walk]1 ! ,lancet & ! ,hygi5ic ,laboratory me?ods = ! valuation ( dis9fectants1 %\ld read ! foll[+3 ,me?od ( ,/&>diz+ ,dis9fectants ) & )\t ,organic ,matt]1 ,j4 ,a4 ,m4 ,a41 ,aug4 #bd1 #aiab1 p4 #ffg2 ,/&>dization ( dis9fectants1 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry1 ,j4 ,a4 ,m4 ,a41 ,april #bf1 #aiac1 p4 #acaf2 ,/&>diz+ ,dis9fectants1 ,j4 ,a4 ,m4 ,a41 ,sept4 #cj1 #aiaf1 p4 #hhc4 ,! ,c\ncil adopt$ ! recomm5dation ( ! ,committee on ,ph>macology to ! effect t ! claims made = ,trime?ol are unsupport$ by acceptable evid5ce4 ,accord+ly1 ,trime?ol & ! ph>maceutical prep>ations said to conta9 x--,trime?ol ,syrup1 ,trime?ol ,capsules1 & ,trime?ol ,tablets--7 held ineligible = ,new & ,non(ficial ,rem$ies4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,aug4 #aa1 #aiag47 ,,f]riv9e1 ,,intram9e ,,& ,,collosol ,,iod9e ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,e4 ,f\g]a ,co41 ,inc41 ,new ,york1 act+ z ag5t = ,! ,briti% ,drug ,h\ses1 ,ltd41 ,london1 adv]tise 8,f]riv9e10 8,intram9e0 & 8,collosol ,iod9e0 to ! m$ical pr(ession4 ,a circul> entitl$ 8,f]riv9e1 ,! ,new ,anti-,syphilitic ,rem$y0 beg9s3 8,,f]riv9e is ! "n giv5 to f]ric tri-p>a-am9o-b5z5e sulphonate4 ,?is iron comp\nd 0 fir/ prep>$ by ,mr4 ,j4 ,e4 ,r4 ,mc,donagh1 ,f4 ,r4 ,c4 ,s41 by :om x has be5 bo? biologically & cl9ically te/$4 ,x is slightly soluble 9 wat]1 ! solution hav+ an acid reaction4 8,,indications 8,accord+ to ,mr4 ,j4 ,e4 ,r4 ,mc,donagh's rese>*es1 ! phases ( ! ,leucocytozoon syphilids are kill$ by ! lipoid-globul9 molecules ( ! s]um1 :i* possess a /]eo*emical molecul> configuration homolog\s to ^? ( ! lipoid-globul9 molecules ( ! p>asite4 ,! process is "o ( absorption1 a *emico-physical reaction :i* is 9 "p dep5d5t ^u ! supply ( active oxyg54 ,active oxyg5 is =m$ directly by oxidation processes & ! p]oxide necess>y = its =mation directly by r$uc+ processes4 ,oxidation is increas$ by metals & r$uction by non-metals4 ,! non-metal :i* acts 9 ! body z ! normal r$uc+ ag5t is sulphur1 h5ce ! discov]y ( ,intram9e 7see sep>ate pamphlet74 ,! metal :i* acts 9 ! body z ! normal oxidis+ ag5t1 is iron1 h5ce ! discov]y ( ,f]riv9e40 ,a circul>1 8,intram9e1 a ,new ,non-,toxic ,comp\nd = ! ,treatm5t ( ,protozoal & ,*ronic ,bact]ial ,diseases10 exp\nds ,mr4 ,mc,donagh's ideas ( ! treatm5t ( syphilis ) ,f]riv9e & ,intram9e by means ( ! oxidis+ action ( ,f]riv9e & ! r$uc+ action ( ,intram9e & ass]ts3 8,z ! ultimate adm9i/ration ( oxidis+ & r$uc+ ag5ts w b5efit almo/ any infection1 x may be said t ,intram9e is indicat$ 9 all protozoal diseases1 & 9 all *ronic bact]ial diseases1 especially 9 tub]culosis1 presumably 9 leprosy & possibly 9 malignant disease canc]84 ,to ! adm9i/ration ( ,intram9e !re are no contra9dications40 ,we are also told t3 8,intram9e is useful inject$ into ! ure?ra4444 ,9 cases ( *ronic ure?ritis & p]ifolliculitis 444 invaluable z a local application to *ronic ulc]s 4440 ,! ,intram9e circul> includes a 8,s*eme ( ,treatm5t = ,syphilis0 :i* advises1 9 addition to ,intram9e1 ,f]riv9e or salv>san1 m]cury & iodids1 ! use ( ano!r propriet>y call$ 8,collosol ,iod9e40 ,an inquiry address$ to ,f\g]a ,co4 9 reg>d to ! "* & composition ( ?is prep>ation1 br\ght ! reply t ! firm _h no k ( its id5tity4 ,?is 8s*eme ( treatm5t0 is objectionable 9 t x advises ! 8/ock0 treatm5t ( a disease :i* dem&s individualization & fur!r 9 t :atev] b5eficial effects may result f ! use ( m]cury & iodid is likely to be ascrib$ to ! prep>ations 8,intram9e10 8,f]riv9e0 & 8,collosol ,iod9e40 ,! adv]tis+ = ,f]riv9e & ,intram9e s5t out by ,f\g]a ,co4 conta9s no exp]im5tal or cl9ical data on :i* an e/imate ( _! value may be bas$4 ,app>5tly 9 ,engl&1 :]e ^! products 7 orig9at$1 little has be5 publi%$ reg>d+ !m4 ,!re is1 h[ev]1 "o report :i* may be accept$ z a c>efully controll$ cl9ical trial4 ,9 ! ,lancet 7,june #ag1 #aiaf1 p4 #abad7 ,l4 ,w4 ,h>rison1 ,d4,s4,o41 ,m4,b41 ,*4,b4,glasg41 & ,c4 ,h4 ,mills1 ,m4,r4,c4,s41 ,l4,r4,c4,p4,lond41 report on 8,! ,effect ( ,f]riv9e & ,intram9e on ,syphilis40 ,aft] briefly review+ ! !ories :i* =m ! basis ( ,mc,donagh's propos$ treatm5t ( syphilis ) 8 discov]ies 8,f]riv9e0 & 8,intram9e0 ! au?ors po9t out3 8444 t ,mr4 ,mc,donagh's biological discov]ies 444 h n be5 publicly confirm$ by any biologi/ ( /&+ 4440 ,:ile3 8444 em95t *emi/s h confess$ !mselves unable to und]/& 8 *emi/ry40 ,! au?ors expla93 8,recogniz+ t ?is might prejudice our practical te/s ( ,intram9e & ,f]riv9e1 we h tak5 p>ticul> c>e to gu>d aga9/ _! influ5ce1 cross-*eck+ our obs]vations & submitt+ !m to o!rs = confirmation or o!rwise40 ,h>rison & ,mills *ose = a te/ ?ree ord9>y cases ( second>y syphilis1 cases ) well m>k$ lesions1 ! cl9ical progress ( :i* c\ld easily be wat*$ & f :i* x 0 easy to obta9 specim5s = microscopic exam9ation4 ,aft] a detail$ acc\nt ( ! ?ree cases--:i* records grave conditions result+ f ! treatm5t & :i* %[s ! ineffici5cy ( ! drugs--!y write3 8,f ! above acc\nt x w be se5 t ! local & g5]al reactions :i* foll[ ! injection ( ^! prep>ations are by no means pleasant4 ,9 ! case ( ,intram9e ! pa9 is undilut$ torture & la/s s = two or ?ree days4 ,"o ( u _h previ\sly treat$ f\r cases ) ,intram9e & ! same local reaction occurr$ 9 ^!4 ,9 two ( !m abscesses h bur/ outw>dly1 "o ( :i* is /ill dis*>g+ necrotic dbris1 t5 weeks aft] ! injection1 & w take _m m weeks to close4 ,9 ^? cases :]e no abscess has yet bur/ x is easy to feel by ! gap 9 ! muscles t consid]able necrosis has occurr$4 ,none ( ^! effects c be ascrib$ to sepsis1 z mo/ rigid aseptic precautions 7 tak54 ,fur!r1 p>ticul> c>e 0 tak5 to make ! injections /rictly intramuscul>4 ,! con/itutional symptoms :i* foll[ imm$iately ^u ! injection ( ,f]riv9e are di/9ctly al>m+1 & su* z w\ld cause "o to hesitate be=e inject+ ?is rem$y into any b robu/ pati5ts40 ,h>rison & ,mills e/imate ! !rapeutic effects ( ^! drugs ?us3 8#a4 ,t ,f]riv9e entirely fail$ to cause ,s4 pallida to disappe> f ! lesions ( ?ree well-m>k$ cases ( second>y syphilis4 8#b4 ,aft] ! failure ( ,f]riv9e to cause ! disappe>ance ( ,spiro*aeta pallida f a muc\s pat* a s+le dose ( #j4c gm4 salv>san effect$ ?is 9 #ah h\rs1 & ! pat*1 :i* _h hi!rto be5 un9flu5c$1 _h heal$ )9 #dh h\rs4 8#c4 ,cl9ically we 7 unable to detect any influ5ce ( ei!r or bo? ^! comp\nds on syphilitic lesions1 al?\gh ea* ( !m 0 ( ! v>iety :i* heals 9 a week or t5 days "u salv>san treatm5t4 8#d4 ,fur!r syphilitic lesions appe>$ imm$iately aft] ! treatm5t 9 "o ( ! two cases treat$ ) bo? ,f]riv9e & ,intram9e4 ,a muc\s pat* appe>$ on "o tonsil z well z fur!r syphilitic papules f :i* spiro*etes 7 obta9$4 ,! o!r case develop$ nephritis1 ) album9 & epi!lial ca/s2 :i* 0 n pres5t prior to ! injections40 ,:ile f ^! cases ! obvi\s conclusion 0 drawn t ,intram9e & ,f]riv9e 8h no specific effect on e>ly syphilis10 ^! au?ors subsequ5tly treat$ a case ( t]ti>y syphilis ) ! drugs4 ,an ,intram9e injection caus$ pa9 = sev]al days b did n /op ! progress ( ! disease4 ,f]riv9e 0 !n adm9i/]$ 8n )\t a feel+ ( grave responsibility0 9 view ( _! previ\s exp]i5ces4 ,!y /ate t 8! reaction :i* result$ 9 ?is in/ance 0 ! mo/ sev]e0 !y ev] exp]i5c$ aft] an intrav5\s injection ( any ( ! antisyphilitic rem$ies ) :i* !y _h previ\sly work$4 ,x is /at$ t 8= a p]iod ( "s m9utes !re 0 grave d\bt z to ! pati5t's survival40 ,aft] resuscitation ! pati5t pass$ a di/urb$ night1 & rigors :i* ensu$ la/$ until ! foll[+ aft]noon4 ,! au?or's report t 9 ?is case also no cl9ical improvem5t occurr$ & t ! ,intram9e-,f]riv9e treatm5t 0 replac$ by a c\rse consi/+ ( salv>san1 potassium iodid & m]curial inunction4 ,f]riv9e1 ,intram9e & ,collosol ,iod9e 7 decl>$ inadmissible to ,new & ,non(ficial ,rem$ies4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,sept4 #h1 #aiag47 ,,eskay',s ,,neuro ,,phosphates ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,= ! in=mation ( ! pr(ession ! ,c\ncil has prep>$ & au?oriz$ = publication ! foll[+ report on ,eskay's ,neuro ,phosphates4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,eskay's ,neuro ,phosphates 7,smi?1 ,kl9e ,fr5* ,co41 ,philadelphia7 is (f]$ to physicians "u ! claims t x conta9s alcohol1 #ag p] c5t41 & sodium glyc]ophosphate1 #b gra9s1 calcium glyc]ophosphate1 #b gra9s1 & /ry*n9 glyc]ophosphate1 #a_/fd gra91 9 ea* dess]tspoonful4 ,x is call$ a 8,n]ve ,tissue ,recon/ructive10 & its adv]tis+ claims are bas$ on ! discr$it$ !ories t c]ta9 disord]s are due to a defici5cy ( phosphorus 9 ! n]ve /ructure ( ! body1 & t glyc]ophosphates are assimilat$ m readily ?an ord9>y phosphates4 ,?is assumption 0 bas$ on ! k t ! leci?9s1 :i* =m a "p ( ! n]ve /ructure1 conta9$ ! glyc]ophosphate radical 9 ! molecule4 ,9 l9e ) ?is1 ,smi?1 ,kl9e ,fr5* ,co4 av]3 8,eskay's ,neuro ,phosphates is ( m>k$ value 9 _m acute & *ronic conditions1 9 n]v\s exhau/ion foll[+ m5tal & physical /ra91 neura/h5ia1 p>alysis1 anemia1 tub]culosis1 m>asmus1 debility & wa/+ diseases g5]ally1 & ! n]ve-weakness ( ! ag$4 ,x is p>ticul>ly useful 9 convalesc5ce f acute diseases & 9 ! n]v\s condition foll[+ la grippe40 ,9 its report on 8,! ,!rapeutic ,value ( ! ,glyc]ophosphates0 7,! ,j\rnal1 ,sept4 #cj1 #aiaf1 p4 #ajcc7 ! ,c\ncil po9t$ out t ! !rapeutic use ( ! glyc]ophosphates 0 bas$ on ! assumption t ! inorganic phosphates _c supply ! body's ne$s ( phosphorus or t ! use ( organic comp\nds 8sp>$0 ! sy/em ! necessity ( mak+ su* syn!sis4 ,! report pres5t$ evid5ce to %[ t ! glyc]ophosphates are n absorb$ z su*1 b t !y are split into inorganic phosphates be=e absorption4 ,! ,c\ncil %[$ t !re 0 conv9c+ evid5ce t ! animal organism syn!sizes its complex organic phosphorus con/itu5ts f inorganic phosphates1 & t organic phosphorus is ( no m value z a food ?an inorganic4 ,despite ?is ! ,neuro ,phosphates adv]tis+ makes use ( ! fallaci\s assumption reg>d+ ! action ( ! glyc]ophosphates4 ,plead+ = ! p>ticul> mixture repres5t$ by ! propriet>y1 x is ass]t$ t3 8,sodium glyc]ophosphate is ( special value 9 neura/h5ia1 ,addison's disease1 phosphaturia & ph?isis40 & t calcium glyc]ophosphate 8is employ$ 9 bone fracture1 ra*itis1 tub]culosis & v>i\s wa/+ diseases40 ,! phosphorus cont5t ( #a_/fd gra9 ( /ry*n9 glyc]ophosphate is ridicul\sly small4 ,yet x is ass]t$ t ?is /ry*n9 salt is ( sup]ior value because x comb9es ! effects ( /ry*n9 ) a 8food-l =m ( phosphorus40 ,eskay's ,neuro ,phosphates has an acid reaction :i* is capitaliz$1 ?us3 8,exp]im5ts h %[n t ! acid glyc]ophosphates are m rapidly absorb$ & are m effici5t ?an ! neutral salts40 ,& z a fur!r illu/ration ( extravagant claims3 8,z a glyc]ophosphoric acid 9 ! =m ( leci?9 is normally pres5t 9 sp]matozoids1 x is b natural t ! glyc]ophosphates %\ld exhibit aphrodisiac effects 7z has be5 obs]v$71 b ?is result does n seem to obta9 9 all cases40 ,is ?is a clumsy attempt to exploit ?is 8n]ve phosphate0 z a 8lo/ manhood0 cure8 ,! ,c\ncil held ,eskay's ,neuro ,phosphates ineligible = ,new & ,non(ficial ,rem$ies because unw>rant$ !rapeutic claims are made = x & because ! adm9i/ration ( /ry*n91 calcium1 phosphate & alcohol is n conducive to rational !rapeutics1 p>ticul>ly :5 su* a mixture is m>ket$ "u a "n :i* indicates b "o ( its con/itu5ts4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,sept4 #bi1 #aiag47 ,k-,y ,,lubricat+ ,,jelly ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,because ( inquiries receiv$1 ! ,c\ncil has au?oriz$ publication ( ! foll[+ report decl>+ ,k-,y ,lubricat+ ,jelly inadmissible to ,new & ,non(ficial ,rem$ies4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,k-,y ,lubricat+ ,jelly 7,van ,horn & ,sawtell1 ,new ,york71 orig9ally adv]tis$ z a lubricant = in/rum5ts & ! h&s1 is n[ also recomm5d$ z a !rapeutic ag5t4 ,if ! claims = 8,k-,y0 7 limit$ /rictly to su* effects z result f ! purely me*anical prop]ties ( a lubricant1 x might be held t x w\ld n come "u ! purview ( ! ,c\ncil4 ,! prep>ation1 h[ev]1 :ile introduc$ z a lubricant1 is n[ (f]$ = a broad] field ( use1 & ! manufactur]s make claims :i* are n support$ by any evid5ce available to ! ,c\ncil4 ,evid5ce ! foll[+1 tak5 f a circul> t accompanies ! package3 8,k-,y allays sm>t+ & burn+ at once ?r\gh its pron\nc$ soo?+ & cool+ effects1 & ?us makes an admirable dress+ = burns40 8,_m physicians make a practice ( ano9t+ ! bodies ( _! measle & sc>let fev] pati5ts ) #8,k-,y1' 9 ?is way af=d+ gratify+ relief f it*+ & irritation1 & effectively prev5t+ dissem9ation ( infecti\s mat]ial40 ,& ?is f ano!r circul>3 8,i _h "o ( ! mo/ tr\blesome cases ( pruritus vulv t ,i _h ev] se54 ,i guess ,i mu/ h tri$ ev]y?+ & ! case _h be5 ref]r$ to me by ano!r man1 :o _h previ\sly tri$ ev]y?+1 includ+ caut]ization4 ,well1 "o day ,i 0 exam9+ h]1 & ( c\rse ,k-,y on ! speculum--! irritation seem$ to quiet d[n1 & ! foll[+ day %e said %e felt no effects f x at all4 ,!n lat] on1 x return$1 & ,i c\ldn't imag9e :at _h done s mu* good1 unless x c\ld h be5 ! lubricant1 s ,i told h] to buy a tube1 :i* %e did4 ,e once 9 a :ile %e has a return ( x slightly1 b %e j applies ,k-,y & cle>s x all up40 ,! manufactur]s /ate t !y d n "k :y ,k-,y is s soo?+1 b sugge/3 8,possibly ! cool+ action ( ! comb9ation1 & ! effect ( ! #d boric acid conta9$1 are factors t ent]4 ,be all t z x may1 ! fact c]ta9ly rema9s t (t5times1 aft] o!r local measures fail1 #8,k-,y' lubricat+ ,jelly gives relief40 ,else:]e x is claim$ to be g]micidal1 & to give relief 9 o!r conditions1 ?us3 8,diabetic & uremic irritations1 n only ( ! g5italia1 b ( o!r p>ts1 h be5 f\nd fully z am5able z pruritus vulvae to ! soo?+ influ5ce ( #8,k-,y' ,lubricat+ ,jelly1 especially if ! previ\s application is remov$ ) wat] e "t a new "o is put on40 ,! =ego+ citations are obvi\sly int5d$ l>gely = ! public1 & make x pla9 t 8,k-,y0 ,jelly is n 9 ! class ( nonm$ical & h>mless ext]nal applications2 on ! contr>y1 ^! claims t5d to create ! impression t ! spread ( measles & sc>let fev] c be prev5t$ 9 ! /age ( desquamation4 ,to place su* /atem5ts 9 ! h&s ( ! pati5t support$ by ! tacit endorsem5t ( a prescription is to create a false & dang]\s s5se ( security & to lead to a failure to obs]ve o!r & m important means ( prev5t+ dissem9ation ( ^! diseases4 ,! ,c\ncil held ,k-,y ,lubricat+ ,jelly 9 conflict ) ,rules #a1 #d1 #f & #aj1 & au?oriz$ publication ( ?is report4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,sept4 #bi1 #aiag47 ,,ziratol ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,ziratol 7,bri/ol-,my]s ,company1 ,new ,york71 9 compliance ) ! f$]al 8insecticide law10 is decl>$ to conta9 #cb p] c5t4 wat] & #cj p] c5t4 glyc]9 z in]t con/itu5ts4 ,reg>d+ its active con/itu5ts ! manufactur] makes ! foll[+ & mean+less /atem5t3 8,ziratol is prep>$ f ,ph5ols ( ! ,naph?al5e s]ies & consi/s ( a solution ( su* ,ph5ols 9 a mixture ( soap1 wat] & glyc]940 ,9 response to inquiry1 ! ,a4 ,m4 ,a4 ,*emical ,laboratory exam9$ ,ziratol & report$ t its ess5tial con/itu5t appe>s to be alpha-nap?ol1#abj & t x has1 ess5tially1 ! foll[+ composition by weight3 ,alpha-nap?ol #ah p] c5t41 soap #bj p] c5t41 glyc]9 & wat] suffici5t to make #ajj p] c5t4 #abj ,alpha-nap?ol 0 also f\nd to be ! basis ( ! no/rum ,b5etol4 ,see ,! ,j\rnal1 ,april #ae1 #aiaa1 p4 #aabh4 ,a ,ziratol adv]tis+ circul> gives a tabulat$ report ( g]micidal te/s1 said to h be5 made accord+ to ! me?od ( ! ,hygi5ic ,laboratory ( ! ,u4 ,s4 ,public ,heal? ,s]vice4 ,:5 ?is "w 0 done is n /at$4 ,accord+ to ^! te/s ,ziratol possesses a ph5ol-coeffici5t ( #ac4ff4 ,! claim t ,ziratol is t5 times m effici5t ?an c>bolic acid 7ph5ol7 is evid5tly bas$ on ?is report4 ,^! claims ( high g]micidal value are contradict$ by an exam9ation made = ! ,c\ncil4 ,a specim5 pur*as$ 9 ! op5 m>ket 0 exam9$ indep5d5tly by two op]ators1 to det]m9e ! ,hygi5ic ,laboratory ph5ol-coeffici5t4 ,"o obs]v] f\nd ! ph5ol coeffici5t to be #b4ed4 ,! o!r report$ x to be #c4ji4 ,evid5tly ! g]micidal value ( ,ziratol is greatly exagg]at$ 9 ! adv]tis+ claims &1 9 fact1 does n exce$ t ( ! (ficial comp\nd solution ( cresol 7,liquor ,cresolis ,compositus1 ,u4 ,s4 ,p47 = :i* a ph5ol-coeffici5t ( ab\t ?ree has be5 e/abli%$4 7,see ,new & ,non(ficial ,rem$ies1 #aiag1 p4 #hb47 ,! claim t ,ziratol is 8! ,univ]sal ,antiseptic & ,g]micide0 is manife/ly an unw>rant$ exagg]ation4 ,! ref]ee 9 submitt+ ?is report to ! ,c\ncil recomm5d$ t ,ziratol be held 9 conflict ) ,rule #a 7secrecy ( composition7 & ,rule #f 7unw>rant$ & exagg]at$ claims74 ,aft] ! report _h be5 submitt$1 x 0 f\nd t a new adv]tis+ circul>1 accompany+ a trade package1 no long] conta9$ ! claim t 8,ziratol is t5 times m effici5t ?an ,c>bolic ,acid40 ,! old] circul> made ! foll[+ /atem5t3 8#a4 ,/rong ,activity4--,comp>$ ) ! bact]icidal action ( ,c>bolic ,acid by ! me?od ( ! ,hygi5ic ,laboratory ( ! ,m>9e ,hospital ,s]vice1 ,,ziratol has ! ,c>bolic ,acid ,coeffici5t ( m ?an ,,t51 t is1 ,,ziratol is ,,t5 times m effici5t ?an ,c>bolic ,acid1--a /r5g? unapproa*$ by any o!r ( its class4 ,,ziratol 9 dilution ( #a3adjj kills ! ,typhoid ,bacillus 9 #b-a_/b m9utes1 ?us prov+ t x is /rongly active ev5 9 v weak solutions40 ,! new adv]tis+ circul> reads3 8#a4 ,/rong ,activity--,ext5sive bact]iological inve/igations on _m pa?og5ic organisms1 conduct$ 9 ! ,l$]le ,laboratories ( ,new ,york1 prove conclusively ! high bact]icidal value ( ,ziratol 9 extremely dilute solutions4 7,a copy ( ! complete report w be mail$ ^u reque/470 ,9 response to a reque/1 ! ,bri/ol-,my]s ,company s5t a copy ( ! bact]iologic inve/igations ( ,ziratol1 said to h be5 made by ! ,l$]le ,laboratories4 ,! organisms employ$ = ^! te/s 7 ,/aphylococcus aureus1 ,/aphylococcus albus1 ,/reptococcus1 ,gre5 pus bacillus1 ,b4 coli1 & saliva4 ,no te/s are giv5 ) ! typhoid bacillus4 ,! conclusion is rea*$ t 89 all ! te/s ! solutions ( ,ziratol h sev]al times great] kill+ effici5cy ?an ^? ( ph5ol40 ,! 8coeffici5ts0 or comp>ative values :i* c be calculat$ f ! results aft] exposure ( #ae m9utes to ! dis9fectants range f #b4j to #d4j4 ,?is is 9 sub/antial accord ) ! ref]ee's f9d+s z reg>ds ! ph5ol-coeffici5t ) ,b4 typhosus z ! te/ object4 ,:ile ! new adv]tis+ circul> avoids ! =m] claim t ,ziratol is t5 times m effici5t ?an c>bolic acid1 9 g]micidal value1 x /ill makes ! unw>rant$ claims t ,ziratol is ! 8univ]sal dis9fectant40 ,! ,c\ncil decl>$ ,ziratol inadmissible to ,new & ,non(ficial ,rem$ies 7#a7 because its composition is secret 7,rule #a72 7#b7 because ! ph5ol coeffici5t1 det]m9$ accord+ to ! me?od ( ! ,hygi5ic ,laboratory1 ,u4 ,s4 ,p4 ,h4 ,s41 is n /at$ on ! label 7,rule #b72 7#c7 because ! label & ! circul> accompany+ ! trade package advises its use by ! public z a 8vag9al d\*e0 7,rule #c72 & 7#d7 because ! claim t ,ziratol is ! 8univ]sal dis9fectant0 is exagg]at$ & unw>rant$ 7,rule #f74 ,be=e au?oriz+ publication ( ! prec$+ report ! ,c\ncil submitt$ x to ! ,bri/ol-,my]s ,company 9 ord] to give t company ! opportunity ( revis+ its me?od ( m>ket+ ,ziratol4 ,9 reply ! company enl>g$ on its )drawal 7on 8our own initiative07 ( ! claim t ,ziratol _h a ph5ol-coeffici5t ( ov] t5 :5 ?is claim 0 %[n to be incorrect 8by au?oritative s\rces40 ,"o wond]s :e!r ?is is a euphemi/ic ref]5ce to ! proce$+s ( ! f$]al au?orities "u ! ,insecticide ,act aga9/ ! ,bri/ol-,my]s ,company1 j made public1#aba because ( ! false claims made = ! g]micidal effici5cy ( ,ziratol4 ,?is prosecution result$ 9 ! seizure & condemnation ( two lots ( ?is propriet>y :i* _h pass$ 9 int]/ate comm]ce4 #aba ,u4 ,s4 ,dept4 ( ,agric41 ,insecticide & ,fungicide ,bo>d1 ,s]vice & ,regulatory ,ann\ncem5ts1 ,no4 #af1 issu$ ,aug4 #h1 #aiag4 ,no4 #bdd1 ,misbr&+ ( 8,ziratol40 ,u4 ,s4 v4 #ajj bottles1 m or less1 ( 8,ziratol02 cons5t decree ( condemnation & =feiture2 product ord]$ releas$ on bond1 p4 #bdh4 ,no4 #bef1 ,misbr&+ ( 8,ziratol40 ,u4 ,s4 v4 #icf bottles & #f jugs ( ,ziratol1 cons5t decree ( condemnation & =feiture2 product ord]$ releas$ on bond1 p4 #bfj4 ,! ,bri/ol-,my]s ,company 9 reply+ to ! ,c\ncil's report made no (f] to decl>e ! exact composition ( ,ziratol1 to /ate ! actual ph5ol-coeffici5t1 or to remove ! o!r objections po9t$ out 9 ! report ( ! ,c\ncil4 ,9 o!r words1 ! ,bri/ol-,my]s ,company has ab&on$ a def9ite b false claim ( high g]micidal p[]--a claim :i* subject$ ! firm to f$]al prosecution--& has sub/itut$ !re= indef9ite /atem5ts :i* d n def9e ! actual g]micidal effici5cy ( ,ziratol4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,oct4 #f1 #aiag47 ,,gonosan ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has adopt$ ! foll[+ report on ,gonosan & au?oriz$ its publication4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,gonosan 7,ri$el & ,company1 ,inc41 ,new ,york ,city7 comes 9 ! =m ( capsules1 ea* said to conta9 #e m9ims ( a mixture compos$ ( oil ( s&alwood #hj p] c5t41 & #bj p] c5t4 ( alpha- & beta-res9 ( kava1 isolat$ by a pat5t process4 ,! mixture1 z ! "n implies1 is int5d$ = ! treatm5t ( gonorrhea4 ,?is propriet>y prep>ation 0 "u consid]ation by ! ,c\ncil at v>i\s times f #aije to #aiaj4 ,dur+ ?is "t1 ! ,c\ncil agre$ to accept ! prep>ation if ! sugge/ive "n 0 *ang$1 ! !rapeutic exagg]ations ab&on$1 & ! drug kava admitt$ to ,new & ,non(ficial ,rem$ies4 ,! "n 0 n *ang$1 ! o!r que/ions 7 left op51 & ! prep>ation 0 n accept$4 ,rec5t & m objectionable adv]tis+ ( ,gonosan makes x advisable = ! ,c\ncil to take action & to publi% a report4 ,! tone ( ?is adv]tis+ is reflect$ by ! foll[+ quotation f a rec5t adv]tis+ circul>3 8,! old-e/abli%$ balsamic treatm5t ( gonorrhea1 = "s ye>s neglect$ 9 favor ( ! local injection ( organic silv] & o!r g]micidal salts1 has1 ) ! increas+ k & att5tion paid to ! composition & purity ( ! balsams1 rega9$ to a l>ge ext5t ! confid5ce =m]ly repos$ 9 !m4 8,x may n[ be said t ! comb9$ treatm5t ) local injections & int]nal adm9i/ration ( natural balsamic products completely dom9ates mod]n gonorrheal !rapy40 ,any "o conv]sant ) curr5t m$ical lit]ature & practice w\ld /amp ^! /atem5ts z mislead+ exagg]ations4 ,! balsams1 oleores9s & volatile oils may h "s value z m9or adjuvants 9 ! treatm5t ( gonorrhea1 b t is all4 ,! position 9 ?is respect has n *ang$ mat]ially 9 rec5t ye>s4 ,^! ag5ts d n h a value equal to t ( local treatm5t1 z ! quot$ /atem5t implies4 ,! claims made = ,gonosan might ) equal =ce be made = oil ( santal alone4 ,kava kava1 ! o!r con/itu5t1 belongs to ! pepp] family2 x _h a tempor>y vogue "s two or ?ree decades ago1 b has fail$ to ma9ta9 a place4 ,x has nev] be5 recogniz$ (ficially4 ,!re is no sci5tific evid5ce t x has any value ei!r alone or z an adjuvant to s&al oil4 ,! 8cl9ical reports0 quot$ 9 ! adv]tis+ circul>s1 r curi\sly1 ne>ly all date back t5 ye>s or m1 viz41 to a p]iod :5 ! attitude ( ! pr(ession t[>d propriet>y rem$ies 0 less critical ?an x is n[4 ,x w\ld be int]e/+ to "k :e!r ^! au?ors /ill adh]e to _! op9ion1 or :e!r any ( !m h subsequ5tly _h exp]i5ces simil> to t ( a correspond5t :o wrote3 8,gonosan1 at my h&s1 did n prove to be ( m ess5tial value 9 ! treatm5t ( gonorrhea ?an any o!r s&alwood oil prep>ation4 ,! v>i\s claims made = ,gonosan1 t x possesses s$ative & ane/hetic prop]ties1 t by its cont9u\s use ! ure?ral dis*>ge disappe>s m rapidly & t1 if comb9$ ) appropriate diet & re/1 x is liable to prev5t complications1 are1 accord+ to my exp]i5ce1 n corroborat$ by actual results40 ,! only exp]im5tal "w quot$ 9 support ( ,gonosan1 t ( ,pohl1 is n conv9c+4 ,! doses t ,pohl f\nd necess>y to influ5ce exp]im5tal purul5t pleurisy makes x impossible to transf] 8 "w to ! cl9ic4 7,he f\nd a dosage ( oil ( santal correspond+ to an ounce p] day1 = man1 ineffici5t2 positive results 7 obta9$ only ) #b ounces p] day47 ,9 ord] to le>n ! e/imate plac$ on ! !rapeutic value ( ! 8balsams10 an inquiry 0 s5t to ! au?ors ( ! pap]s pres5t$ to ! section ( ,g5ito-,ur9>y ,diseases at ! rec5t meet+ ( ! ,am]ican ,m$ical ,association 9 ,new ,york4 ,! inquiry read3 8,de> ,doctor3--,an adv]tis+ circul> = ,gonosan #8,ri$el' :i* is n[ be+ di/ribut$ beg9s ?us3 #8,! old-e/abli%$ balsamic treatm5t ( gonorrhea1 = "s ye>s neglect$ 9 favor ( ! local injection ( organic silv] & o!r g]micidal salts1 has1 ) ! increas+ k & att5tion paid to ! composition & purity ( ! balsams1 rega9$ to a l>ge ext5t ! confid5ce =m]ly repos$ 9 !m4' #8,x may n[ be said t ! comb9$ treatm5t ) local injections & int]nal adm9i/ration ( natural balsamic products completely dom9ates mod]n gonorrheal !rapy4' 8,is ! /atem5t correct t ! comb9$ treatm5t ) local injections & int]nal adm9i/ration ( natural balsamic products completely dom9ates mod]n gonorrheal !rapy8 ,y\r reply to ! above w be appreciat$ by ! ,c\ncil40 ,sev5te5 replies 7 receiv$4 ,!y be> out ! position t has be5 outl9$4 ,only "o writ] consid]$ ! /atem5t ev5 approximately ju/ifi$1 & ?is 9 ! s5se t 8! majority ( cases receive no o!r treatm5t0 ?an a comb9ation ( local applications & sy/emic m$ication4 ,ano!r /at$ t1 89 a g5]al way _! /atem5t is true ?\gh a trifle too sweep+10 & !n add$ t ! field ( ! balsams is r re/rict$4 ,) ! exception ( ^! qualifi$ endorsem5ts ! rema9+ 7fifte57 replies *>act]iz$ ! /atem5t z incorrect & mislead+4 ,! replies are a valuable contribution to ! /atus ( ! 8balsam0 treatm5t ( gonorrhea1 & extracts ( !m are app5d$ to ?is report4 ,x is recomm5d$ t ! ,c\ncil decl>e ,gonosan inadmissible to ,new & ,non(ficial ,rem$ies1 because ! !rapeutic claims are exagg]at$ 7,rule #f72 because !re is no evid5ce t ! comb9ation ( kava res9 ) oil ( santal is sup]ior to oil ( santal alone 7,rule #aj72 & because ! !rapeutically sugge/ive "n is conducive ( indiscrim9ate & unw>rant$ use ( ! prep>ation bo? by ! pr(ession & ! public 7,rules #d & #h74 ,app5dix ,! extracts f replies receiv$ to ! inquiry above ref]r$ to1 foll[3 ,dr4 ,b41 ,p5n41 wrote3 8,9 my practice ,i h f\nd t local injections are v valuable 9 ! treatm5t ( gonorrhea1 b ,i h nev] f\nd t ! int]nal adm9i/ration ( natural balsamics dom9at$ mod]n gonorrheal !rapy2 :ile x is an aid1 ,i consid] ! quot$ /atem5t to be v errone\s40 ,dr4 ,f41 ,d4 ,c41 wrote3 8,:ile x is d\btless true t acute ure?ritis1 gonorrheal1 is n[ g5]ally treat$ by local injections ( solutions ( organic silv] salts1 & t santal oil is (t5 us$1 x is n true1 z "o w\ld inf] f ! quotation1 t ! balsams are n[ consid]$ m efficaci\s ?an !y 7 =m]ly4 ,s f> z ,i "k !y h n lo/ or rega9$ any?+ dur+ ! pa/ doz5 ye>s 9 ! way ( confid5ce repos$ 9 !m4 ,! indications = _! use is v def9ite & v limit$40 ,dr4 ,b41 ,ga41 wrote3 8444 ,9 rec5t ye>s ,i h almo/ ab&on$ ! use ( balsams1 etc41 9 ! treatm5t ( gonorrhea4 ,pati5ts1 :o are prop]ly treat$ o!rwise1 seem to get along z well )\t su* drugs z ) !m1 9 fact app>5tly bett] = !y h no ga/ric di/urbance4 ,x is important = pati5ts to dr9k freely ( wat] & :5 s do+ ! balsams are s dilut$ t ,i _c conceive ( _! do+ mu* good4 ,=m]ly my pati5ts (t5 lo/ weight dur+ ! treatm5t ( gonorrhea2 n[1 )\t balsams & ) pl5ty ( wat]1 !y usually ga9 9 weight40 ,dr4 ,s41 ,mi*41 wrote3 8444 we believe t 9 a g5]al way _! /atem5t is true ?\gh a trifle too sweep+4 ,we d n ord9>ily use ! balsams 9 uncomplicat$ ant]ior ure?ritis4 ,we d h[ev]1 f9d indication = _! adm9i/ration 9 f sixty to sev5ty five p] c5t4 ( all cases ( acute gonorrhea at "s "t dur+ ! c\rse ( ! disease40 ,dr4 ,l41 ,mo41 wrote3 8,i w\ld say t ! /atem5t t1 #8,! comb9$ treatm5t ) local injections & int]nal adm9i/ration ( natural balsamic products completely dom9ates mod]n gonorrheal !rapy1' is f> f repres5t+ ! facts4 ,:ile ! balsamics may occasionally h an indirect soo?+ effect on ! muc\s membranes involv$1 ! dom9ant factor is local treatm5t1 aim+ at dis9fection & re/oration to normal ( ! inflam$ tissues40 ,dr4 ,r41 ,mi*41 wrote3 8,reg>d+ y\r reque/ al?\gh ,i am will+ to reply x is difficult to d s because if ,i %\ld d s 9 ! affirmative t c\ld apply only to c]ta9 acute cases )\t complication ( any k9d & su* cases are r>e4 ,9 su*1 h[ev]1 ! adv]tis] is n f> f "r--s9ce vacc9e !rapy has prov5 absolutely wor?less we mu/ fall back on antiseptics 9 acute ure?ritis :5 !re are no objections to su* treatm5t 4440 ,dr4 ,k41 ,ill41 wrote3 8,i am "u ! impression t ! int]nal adm9i/ration ( balsamics is us$ only :5 complications arise1 su* z acute po/]ior ure?ritis4 ,p]sonally ,i use ! balsamics v1 v r>ely4 ,f my obs]vation1 h[ev]1 ,i am l$ to believe t _m m5 /ill use int]nal drugs 9 ! treatm5t ( gonorrhea1 & dur+ ! pa/ few ye>s1 ,i %\ld say ! use ( hexame?yl5am9 has be5 on ! increase1 & ! use ( ! balsams on ! decrease4 ,i d n believe t hexame?yl5am9 is ( any value 9 ! treatm5t ( gonorrhea1 & am simply cit+ ?is z my obs]vation ( ! widespread use ( ?is drug 9 ! treatm5t ( gonorrhea40 ,dr4 ,t41 ,p5n41 wrote3 8444 ,i believe t m m5 use salol or hexame?yl5am91 or no ur9>y antiseptic :atsoev]1 ?an use ! balsamics40 ,dr4 ,b41 ,ind41 wrote3 8444 ,! only sy/emic treatm5t t is consid]$ necess>y today is re/1 pl5ty ( wat] & neutralize ! acidity ( ! ur9e ) bic>bonate ( soda or "s sodium salt40 ,dr4 ,y41 ,mass41 wrote3 8,s&al wood oil dur+ ! acute /age ( gonorrhea c]ta9ly t5ds to make ! pati5t m com=table & und\bt$ly does l5d "s 7?o ,i believe slight7 gonococcidal action4 ,t x plays any consid]able "p 9 actual cure ,i ?9k is d\btful4 ,! /atem5t z quot$ is true 9 s f> z x /ates t local treatm5t plus int]nal m$ication ) a balsam comprises mo/ ( ! mod]n treatm5t ( gonorrhea b x is grossly mislead+ 9 t x lets "o draw ! inf]5ce t ! balsam plays a l>ge if n ! pr9cipal "p40 ,dr4 ,h41 ,new ,york1 wrote3 8,= a p]iod ( at lea/ ?ree ye>s 9 my hospital1 disp5s>y & private practice1 ,i consci5ti\sly tri$ out mo/ ( ! balsamics on ! m>ket 7includ+ ,gonosan1 :i* ,i favor$ = "s "t7 bo? alone1 & comb9$ ) local injections4 ,z a result ( ?is /udy1 ,i h come to ! conclusion t ! balsamics h little1 if any value 9 ! treatm5t ( gonorrhea4 ,dur+ ! pa/ few ye>s ,i h reli$ almo/ entirely on local !rapy1 & seldom prescrib$ any ( ! balsams 9 my private practice1 c]ta9ly 9 n m ?an #e p] c5t4 ( ! cases4 ,my results ,i f9d are j z satisfactory1 & my pati5ts appreciate ! fact t !y are n load$ up ) disagreeable m$ication4 ,in/ead ( ! balsamics1 ,i am us+ sodium bic>bonate m & m1 & feel conv9c$ t ! prop] use ( ?is drug is ( m value ?an all ( !m comb9$40 ,dr4 ,k41 ,cal41 wrote3 8,! /atem5t t ! comb9$ treatm5t ) local injections & int]nal adm9i/ration ( natural balsamic products completely elim9ates mod]n gonorrheal !rapy1 w\ld at pres5t n be ju/ifiable ev5 ) ref]5ce to ! initial or acute /age ( gonorrhea1 :ile 9 ! subacute & *ronic =ms ( ! disease local injections & balsams play an almo/ insignificant rle z comp>$ ) v>i\s o!r recogniz$ !rapeutic measures40--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,oct4 #ac1 #aiag74 ,,alcre/a ,,ipecac ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has adopt$ ! foll[+ report & au?oriz$ its publication4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,9 #aiae ,alcre/a ,ipecac ,tablets 7,eli ,lilly & ,co47 7 admitt$ to ,new & ,non(ficial ,rem$ies z a prep>ation ( ipecac t is insoluble 9 ! /oma* b soluble 9 ! inte/9es4 ,x 0 suppos$ t ?is prop]ty w\ld p]mit ! adm9i/ration ( ipecac )\t ! accompany+ nausea & vomit+1 & t ?is w\ld be ( especial advantage :5 us+ ! drug 9 amebic dys5t]y4 ,! sy/emic effects1 ( c\rse1 w\ld be ^? ( ipecac4 ,m rec5tly1 ! manufactur]s ( ,alcre/a ,ipecac h be5 advis+ its use 9 conditions :i* 7 n contemplat$ by ! ,c\ncil :5 ! prep>ation 0 accept$ = ,new & ,non(ficial ,rem$ies4 ,!y n[ claim t ipecac alkaloids h be5 %[n to be useful 9 ! treatm5t ( typhoid fev]1 flatul5ce1 di>rhea & con/ipation & t ,alcre/a ,ipecac has ^! prop]ties4 ,su* a /atem5t is mislead+4 ,:ile x is true t at "o "t ipecac 0 us$ promiscu\sly aga9/ 8flatul5ce1 di>rhea & con/ipation0 !re nev] has be5 & is n n[ any sci5tific evid5ce ( its effici5cy 9 su* conditions except1 ( c\rse1 9 di>rhea ( ! amebic type4 ,z to ! alleg$ usefulness ( ipecac 9 typhoid fev]3 ,?is has n ev5 ! sanction ( tradition & ! claim c]ta9ly %\ld n be accept$ until !re is /rong evid5ce to support x4 ,! adv]tis+ matt] on ,alcre/a ,ipecac also conta9$ /atem5ts to ! effect t ipecac alkaloids h a demon/rat$ usefulness 9 pyorrhea4 ,su* an unequivocal /atem5t is unw>rant$4 ,9 spite ( ! en?usia/ic advocacy1 9 ! pa/1 ( ipecac alkaloids z a specific 9 pyorrhea alveol>is ! prepond]ance ( sci5tific evid5ce indicates t ipecac is ( que/ionable value 9 ?is condition4 ,nei!r is !re any sub/antial evid5ce to w>rant ! claim t ipecac alkaloids1 :5 absorb$ ?r\gh ! inte/9es1 are demon/rably useful 9 amebic infections ( ! tonsils4 ,! reputation ( ! be/ drugs1 :e!r un(ficial or (ficial1 is b\nd to suff] if extravagant claims = !m are p]mitt$ to g un*all5g$4 ,! ref]ee ( ! ,c\ncil1 !re=e1 believ$ x necess>y to call ! att5tion ( ! manufactur]s ( ,alcre/a ,ipecac ,tablets to ! /atem5ts made = ! product & sugge/$ t !y submit evid5ce to sub/antiate ! claims4 ,?is ! manufactur]s h refus$ to d4 ,_! attitude 9 ! matt]1 z well z _! attitude t[>d ! ,c\ncil's "w is express$ 9 ! foll[+ lett]3 8,respond+ to y\r lett] ( ,m>* #aj?1 we beg to sugge/ t lit]ature cov]+ ! diff]5t matt]s at issue are readily available to y\r ref]ee1 & all /atem5ts emanat+ f u are made advis$ly4 8,if y _c satisfy y\rselves t ?is prep>ation is a sci5tific product1 e?ically adv]tis$1 & a desirable advance 9 !rapeutics1 y c only delete x f y\r next issue ( ,new & ,non(ficial ,rem$ies40 ,x is to be regrett$ t ,eli ,lilly & ,co4 refuse ei!r to )draw or modify _! claims or to sub/antiate ^! claims by sci5tific evid5ce4 ,! /atem5ts z !y /& are exagg]at$1 mislead+ & h>mful4 ,z su* !y conflict ) ,rule #f ( ! ,c\ncil & necessitate ! omission ( ,alcre/a ,ipecac f ,new & ,non(ficial ,rem$ies4 ,! ref]ee recomm5d$ ! adoption & publication ( ?is report4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,oct4 #bj1 #aiag47 ,,iodeol ,,& ,,iodagol ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,iodeol & ,iodagol 7=m]ly call$ ,iod>gol7 are products ( ,viel & ,company1 ,r5nes1 ,france1 widely adv]tis$ 9 ?is c\ntry by ,david ,b4 ,levy1 ,incorporat$1 ,new ,york4 ,! claim made = bo? prep>ations is t !y dep5d on 8colloidal iod90 = _! action4 ,!y are put up 9 a numb] ( =ms1 = in/ance3 8,iodeol ,amp\les ea* conta9+ #a c4c4 7#bj c5tigrammes colloidal iod9 9 an oily vehicle740 8,iodeol ,ext]nal1 conta9+ #ej p] c5t4 colloidal iod9e40 8,iodagol ,amp\les1 ea* conta9+ #b c4c4 7#ej c5tigrammes colloidal iod9e 9 an oily vehicle740 ,! claim is1 t1 ! iod9 be+ 9 ! colloidal /ate1 x has ! prop]ties ( elem5t>y iod9 & ?us ! prep>ations may be us$ 9 conc5trations & "u conditions :i* w\ld make ! use ( free iod9 impossible4 ,! products h be5 ext5sively & extravagantly adv]tis$ = use 9 a wide range ( conditions4 ,?us ,iodeol has be5 propos$ 9 ! treatm5t (3 8,pulmon>y ,tub]culosis0 8,l>yngeal ,tub]culosis10 8,gl&ul> ,tub]culosis0 8,tub]culosis ( ! ,bones0 8,pneumonia1 ,bron*o-pneumonia1 & ,conge/ive ,conditions0 8,:oop+ ,c\gh1 ,influ5za1 ,a/hma0 8,typhoid ,fev]0 8,syphilis0 8,obesity40 ,iodagol1 :i* is = ext]nal use1 has be5 advis$ 9 ! treatm5t (3 8,gonorrhea & its ,sequel0 8,cy/itis0 8,tetanus0 8,w\nds complicat$ by gase\s gangr5e0 8,burns0 8,old ,suppurations1 ulc]s1 abscesses1 etc40 8,articul> rheumatism0 8,abscess ,alveol>0 8,pyorrhea ,alveol>is0 8,/omatitis 7,cank]-,sores740 ,ne>ly two ye>s ago ! ,am]ican ag5ts reque/$ ! ,c\ncil to consid] ,iodeol & ,iodagol = admission to ,new & ,non(ficial ,rem$ies4 ,! in=mation submitt$ 9 reg>d to _! "* & composition 0 vague & indef9ite1 ! ph>macologic in=mation practically nil & ! cl9ical data z volum9\s z x 0 unconv9c+4 ,on ! basis ( *emical1 ph>macologic1 bact]iologic & cl9ical inve/igation c>ri$ out "u ! direction ( ! ref]ee & a /udy ( ! submitt$ evid5ce1 ! ref]ee report$3 #a4 ,iodeol & ,iodagol d n conta9 ! am\nt ( iod9 claim$4 #b4 ,! iod9 is n pres5t z elem5t>y iod91 b in/ead ! prep>ations behave simil>ly to ! well-kn[n organic iod9 comp\nds su* z iodiz$ fats4 #c4 ,! !rapeutic claims made = ! prep>ations are exagg]at$ & unw>rant$4 ,9 view ( 8 f9d+s he recomm5d$ t ,iodeol & ,iodagol be decl>$ inadmissible to ,new & ,non(ficial ,rem$ies = conflict ) ,rules #a & #b 7mislead+ /atem5ts reg>d+ composition & id5tification7 & ,rule #f 7unw>rant$ !rapeutic claims74 ,! ,c\ncil adopt$ ! recomm5dation ( ! ref]ee1 direct+ inclusion ( ! full report 9 ! annual ,c\ncil reports aft] submission to ! manufactur]1 & recomm5d+ publication ( an ab/ract ( ?is report 9 ,! ,j\rnal4 ,?is report 0 br\ght to ! att5tion ( ! ,am]ican ag5t1 ,david ,b4 ,levy1 ,inc41 & ?r\gh !m to ! ,fr5* manufactur]s1 ,e4 ,viel & ,company4 ,! manufactur]s h intimat$ t !y w n file a reply to ! report4 ,! firm ( ,david ,b4 ,levy1 ,inc41 has decid$ to sev] its connection ) ^! products & to discont9ue _! sale4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,summ>y ( ,ref]ee's ,report ,iodeol & ,iodagol 7 submitt$ to ! ,c\ncil ne>ly two ye>s ago z 8electro-colloidal iod9e0 & ) ! claim t !y produc$ all ! antiseptic & o!r effects ( ord9>y iod9 )\t any ( its side actions4 ,! ref]ee has done mu* "w on ! subject1 conduct$ a l>ge am\nt ( correspond5ce & has cont5d$ ) long delays4 ,he feels t ! consid]ation ( ^! products %\ld be br\ght to a conclusion & accord+ly he submits ?is report ( _! consid]ation4 ,! foll[+ is a summ>y ( ! report1 :i* is app5d$3 ,i4 ,discrepancy 9 ,iod9 ,p]c5tage4--,! exam9ation at ! ,*emical ,laboratory ( ! ,am]ican ,m$ical ,association1 z well z t ( ! ref]ee1 %[s t ! v>i\s samples ( ,iodeol & ,iodagol exam9$ conta9$ a little less ?an "o-half ( ! total iod9 claim$4 ,^! facts 7 report$ to ! ,am]ican ag5t4 ,aft] a l5g?y delay a reply 0 receiv$ :i* pres5t$ a d\ble excuse3 7#a7 t ! full am\nt ( iod9 _h be5 add$1 :atev] _h become ( x lat]2 7#b7 t ! claims 7 made = 8colloidal iod90 & t ?is is n elem5t>y iod9 9 ! colloidal /ate1 b a prep>ation ( iod9 conta9+ only #ej p] c5t4 ( real iod94 ,nei!r explanation c be tak5 s]i\sly1 z !y are obvi\s quibbl+s4 ,! ref]ee concludes t ! prep>ations are falsely label$ z to iod9 cont5t4 ,,ii4 ,nature ( ! ,iod9 ,comp\nd 9 ,iodeol & ,iodagol4--,9 ! in=mation s5t ! ,c\ncil1 ,iodeol & ,iodagol 7 def9$ z 8,a susp5sion ( electro-*emical colloidal iod9 9 a vehicle ( purifi$ oil40 ,num]\s inquiries h fail$ to elicit m specific in=mation f ! manufactur] or 8 ag5t4 ,! /atem5t ( composition c mean only t ! prep>ations conta9 free iod9 7b 9 colloidal =m7 susp5d$ 9 oil4 ,no evid5ce to sub/antiate ?is claim has be5 submitt$4 7,!re is evid5ce t ! prep>ations conta9 colloidal p>ticles1 b x does n indicate if ?is colloidal mat]ial is iod91 or a comb9ation ( iod9 or inde$ :e!r ! colloidal compon5t conta9s any iod947 ,! rec5t /atem5ts ( ! ag5t seem to conc$e t :at !y call 8electro-colloidal iod90 conta9s only ab\t #ej p] c5t4 ( real iod91 9 o!r words t x is n 8colloidal iod90 at all1 b a mixture or comb9ation ( iod9 ) "s o!r unnam$ sub/ance4 ,?is1 ( c\rse1 is some?+ v diff]5t4 ,c]ta9 results report$ f ! ,am]ican ,m$ical ,association's ,*emical ,laboratory sugge/ t ! s-call$ 8colloidal iod90 ( ,iodeol may be a comb9ation ( iod9 ) a volatile oil4 ,! inve/igations ( ! ref]ee indicate t ! iod9 exi/s 9 a r resi/ant =m or comb9ation behav+ altoge!r diff]5tly f ord9>y free iod91 & r resembl+ ! behavior ( iod9 sub/itution products1 su* z iodiz$ fats or ph5ols4 ,briefly !n ! rec5t admissions ( ! ag5ts indicate t ,iodeol does n conta9 8colloidal iod90 9 a *emical s5se1 & !re are indications t x does conta9 its iod9 9 a r firm 7*emical7 comb9ation4 ,,iii4 ,*emical ,prop]ties ( ,iodeol4--,f a /udy ( diff]5t specim5s ( ,iodeol1 ! ref]ee concludes t fre% specim5s conta9 no free iod9 & t old ones conta9 small am\nts z a result ( decomposition4 ,iodeol has ! solubility *>act]i/ics ( fats & fat-l comp\nds4 ,! exam9ation1 z a :ole1 %[s t ,iodeol conta9s a peculi> & r resi/ant =m or comb9ation ( iod94 ,!re is no?+ 9 ! *emical data t sugge/s t x c\ld act diff]5tly f ord9>y iod9 comp\nds1 su* z iodiz$ fats4 ,x w\ld n act z ord9>y iod94 ,,iv4 ,ph>macologic ,data4--,! ph>macologic /atem5ts :i* 7 submitt$ 7 loose & app>5tly mean+less or mislead+4 ,9 reply to que/ions submitt$ by ! ref]ee1 ! manufactur] f9ally _h "s "w done & submitt$ a report by ,jean ,laumonni]4 ,! ref]ee 0 unable to confirm "s ( ?is "w1 & z a :ole x does n appe> mat]ially to elucidate ! action ( ,iodeol4 ,f a consid]ation ( ! submitt$ evid5ce1 & z a result ( 8 own "w1 ! ref]ee concludes t ,iodeol does n behave l elem5t>y iod92 x does n coagulate prote9s & !re=e is n irritant4 ,x is presumably absorb$1 b q probably aft] *emical *ange2 x is *ang$ into iodid &1 l organic iodids1 is excret$ some:at m sl[ly ?an :5 inorganic iodids are adm9i/]$1 b ! diff]5ce does n appe> important4 ,v4 ,antiseptic & ,bact]icidal ,action4--,elem5t>y iod9 is consid]$ a fairly p[]ful ag5t 9 ^! respects4 ,! activity is presumably due to *anges 9 ! prote9s1 etc41 ( ! bact]ia1 analog\s to ! effects :i* produce pa91 irritation & necrosis ( ! tissue cells4 ,s9ce ! latt] effect is n produc$ by ,iodeol1 x seems highly improbable1 if n impossible1 t x %\ld act on bact]ia l elem5t>y iod94 ,x is entirely unju/ifiable to cr$it ! kn[n antibact]ial qualities ( ord9>y iod9 to 8colloid0 iod94 ,?is misrepres5tation is especially prom95t 9 ! circul> 8,notable ,new ,!rapeutic ,ag5ts10 z w be se51 = in/ance1 f ! foll[+ citations3 8,iod9e has long be5 univ]sally recogniz$ z an antiseptic ( extraord9>y pot5cy4 ,n only is x rapid & c]ta9 9 its g]m-de/roy+ action1 b x also possesses an attribute d5i$ _m o!r antiseptic ag5ts1 namely1 ! p[] to p5etrate & impregnate ! tissues4 ,o!r antiseptics1 z is well kn[n1 act on ! surface epi!lium only40 8,accord+ to ,k9naman 7,j4 ,a4 ,m4 ,a41 ,aug4 #bf1 #aije71 iod9e is f> sup]ior to bi*loride ( m]cury1 a two p] c5t4 solution kill+ /reptococcus pyog5es 9 two m9utes4 ,iod9e does n coagulate album91 & is v p5etrat+40 ,! citations imply t ?is 8colloidal iod90 ( ,iodeol & ,iodagol acts z an antiseptic l ord9>y iod91 except t x is claim$ to be m effici5t by 8diffus+0 m readily4 ,?is is entirely unju/ifi$ & mislead+4 ,if ,iodeol & ,iodagol are really antiseptic1 !y mu/ act by "s o!r me*anism ?an t ?r\gh :i* elem5t>y iod9 acts1 & su* antiseptic action w\ld h to be demon/rat$ by direct obs]vation & n assum$ f ! kn[n action ( free iod94 ,antiseptic & bact]icidal effects are easily e/imat$ by laboratory me?ods4 ,yet no evid5ce on ?is po9t appe>$ to h be5 available until ! ,c\ncil call$ = ?is4 ,laumonni] !n c>ri$ out "s exp]im5ts :i* 7 9 turn submitt$ to bact]iologic control4 ,! bact]iologi/ fail$ to obta9 any results ) "s ( ! te/s1 & consid]$ ! o!r data ( little value4 ,! claim t ,iodeol & ,iodagol h ! antiseptic & bact]icidal action ( free iod9 lacks pro( & mu/ be consid]$ unw>rant$ & mislead+ 9 ! extreme4 ,,vi4 ,cl9ical ,trials4--,! manufactur]s & ag5ts ( ,iodeol pres5t$ _m lett]s f physicians2 b few1 if any1 ( ^! gave evid5ce ( c>eful1 critical1 controll$ obs]vations4 ,!y c\ld n1 !re=e1 be consid]$ z acceptable evid5ce4 ,! m important claims1 lett]s & publi%$ pap]s1 h[ev]1 7 submitt$ to cl9ical speciali/s collaborat+ ) ! ,c\ncil1 ) ! reque/ t !y exam9e ^! & conduct "s cl9ical trials1 if !y consid]$ x advisable4 ,! results obta9$ 9 ^! prelim9>y trials did n appe> suffici5t to w>rant fur!r exp]im5tation4 ,f a consid]ation ( ! evid5ce pres5t$1 ! ref]ee concludes t ! claims made = ,iodeol & ,iodagol are unw>rant$1 exagg]at$ & mislead+4 ,he recomm5ds t ,iodeol & ,iodagol be decl>$ ineligible = ,new & ,non(ficial ,rem$ies = conflict ) ,rules #a & #b 7mislead+ /atem5ts z to composition & id5tification7 & ) ,rule #f 7unw>rant$ & mislead+ !rapeutic claims74 ,he fur!r recomm5ds t ! ,c\ncil au?orize publication ( ! prec$+ summ>y ( ! consid]ation ( ,iodeol & ,iodagol 9 ,! ,j\rnal & inclusion ( ! full report 9 ! annual ,c\ncil reports aft] submission to ! manufactur]4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #ag1 #aiag47 ,,capsules ,,bismu? ,,resorc9ol ,,comp\nd ,,n ,,admitt$ ,,to ,n4 ,n4 ,r4 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,9 response to inquiries receiv$1 ! ,c\ncil took up ! consid]ation ( ,capsules ,bismu? ,resorc9ol ,comp\nd 7,! ,gross ,drug ,company1 ,inc41 ,new ,york ,city74 ,! label1 s5t by ! ,gross ,drug ,company1 bore ! foll[+3 ,,capsules ,,bismu? ,,resorc9ol ,,comp\nd ,bismu? ,subgallate #b grs4 ,resorc9ol #a gr4 ,beta ,naph?ol #a_/b gr4 ,creosote 7,bee*wood7 #a m4 ,?is comb9ation is ( ackn[l$g$ value 9 r$uc+ ! value 9 r$uc+ ! intes- t9al putrefaction & f]m5tation1 allay+ ! pa9 & discom=t ( flatul5t conditions 9 ! inte/9al tract4 ,,dose4--,"o or two capsules be=e or aft] meals repeat$ 9 two h\rs if necess>y4 ,! ,gross ,drug ,company1 ,inc4 #bj ,laight ,/reet1 ,new ,york ,! ,c\ncil held ?is prep>ation inadmissible to ,new & ,non(ficial ,rem$ies or ! ,app5dix1 because 7#a7 ! claim 8ackn[l$g$ value 9 r$uc+ ! inte/9al putrefaction & f]m5tation1 allay+ ! pa9 & discom=t ( flatul5t conditions 9 ! inte/9al tract0 is an unw>rant$1 exagg]at$ & mislead+ claim ( !rapeutic value 7,rule #f72 because 7#b7 ! "n does n indicate ! id5tity ( ! bismu? salt conta9$ 9 ! capsules1 nor decl>e ! pres5ce ( betanaph?ol & creosote 7,rule #h72 & because 7#c7 ! comb9ation ( bismu? subgallate1 resorc9ol1 betanaph?ol & creosote 9 fix$ proportions is irrational 7,rule #aj74--7;,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiag1 p4 #aci47 ,,dixon',s ,,tub]cle ,,bacilli ,,extract ,,& ,,dixon',s ,,susp5sion ,,( ,,dead ,,tub]cle ,,bacilli ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,new & ,non(ficial ,rem$ies1 #aiag1 conta9s g5]al descriptions ( ,dixon's ,tub]cle ,bacilli ,extract & ,dixon's ,susp5sion ( ,dead ,tub]cle ,bacilli2 ! products ( ^! manufactur$ by ! ,h4 ,m4 ,alex&] ,company be+ li/$ z dosage =ms4 ,x hav+ become necess>y to omit ! prep>ations ( ! ,alex&] ,company 7see page #ach7 ! ref]ee recomm5d$ t ! g5]al articles ( 8,dixon's ,tub]cle ,bacilli ,extract0 & 8,dixon's ,susp5sion ( ,dead ,tub]cle ,bacilli0 also be omitt$4 ,he report$ t no o!r firm appe>s to be m>ket+ ^! products & t !y _h n be5 %[n to be ( special value4 ,! ,c\ncil accept$ ! recomm5dation & direct$ ! omission z propos$4 ,9 accordance ) ! proc$ure ( ! ,c\ncil1 ^! h be5 transf]r$ to ! annual ,c\ncil ,reports = ref]5ce & appe> bel[4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,dixon's ,tub]cle ,bacilli ,extract4--,an extract ( tub]cle bacilli dissolv$ 9 normal sal9e solution4 7,see 8,fluid ( ,dixon10 ,m$ical ,news1 ,jan4 #ag1 #ahia47 ,dixon's ,susp5sion ( ,dead ,tub]cle ,bacilli4--,a susp5sion 9 physiologic salt solution ( dead tub]cle bacilli :i* h be5 defatt$ by prolong$ treatm5t ) alcohol & e!r4 7,see 8,possibility ( ,e/abli%+ ,tol]ance = ,tub]cle ,bacilli10 ,m$ical ,news1 ,oct4 #ai1 #ahhi47--7;,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiag1 p4 #adj47 ,,=mosol ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,sun%9e's ,=mosol 7,! ,=mosol ,*emical ,company1 =m]ly ! ,sun%9e ,*emical ,company1 ,clevel&1 ,ohio7 is claim$ to conta9 #ah p] c5t4 =maldehyd 9 a solution ( soap4 ,x is !re=e v simil> to ,v](orm ,g]micide :i* 0 delet$ f ,new & ,non(ficial ,rem$ies because ( ! l[ ph5ol coeffici5t report$ by ! ,hygi5ic ,laboratory ( ! ,unit$ ,/ates ,public ,heal? ,s]vice 7,! ,j\rnal1 ,nov4 #bb1 #aiac1 p4 #aibj47 ,! ,c\ncil vot$ t 9 view ( ! ,hygi5ic ,laboratory's f9d+ t =maldehyd has a l[ g]micidal value1 ! manufactur]s ( ,=mosol be requir$ to produce def9ite evid5ce ( ! degree ( g]micidal value = ?is product4 ,9 submitt+ ! prep>ation to ! ,c\ncil1 x 0 claim$ t ,=mosol _h 8all prop]ties peculi> to ,=maldehyde40 ,?is cons]vative tone 01 h[ev]1 n ma9ta9$ 9 ! =m-lett]s submitt$4 ,^! conta9 ! foll[+ unw>rant$ /atem5ts3 8,z ! "n implies1 ,,=mosol is a =maldehyde prep>ation1 :i* embodies all ! innate antiseptic m]its & elim9ates all ! ill features ( ! _w's greate/ dis9fectant40 8,! elim9ation ( all ! de/ructive elem5ts & ! incorporation ( all ! e/abli%$ !rapeutic virtues ( =maldehyde1 h be5 sci5tifically bl5d$ 9 ,,=mosol40 8,,=mosol is unique 9 ! sph]e ( antisepsis because ( its peculi> heal+ prop]ties z diametrically oppos$ to irritation to ! tissue ( muc\s membrane40 8,,=mosol may be us$ = ! ?\s& niceties ( mod]n antisepsis1 b is specific 9 ,gynecology & ,ob/etrics & is indicat$ 9 ,d]matology40 ,italics n 9 orig9al4 8,! con/ant use ( ,,=mosol is to develop a habit sympa!tic to e?ics40 8,to prescribe ,,=mosol is a great /ep t[>d ,p]sonal ,hygi5e1 a duty ( ! m$ical frat]nity to ! laity40 ,italics n 9 orig9al4 ,! trade package recomm5ds ! use ( ,=mosol 8= cuts1 w\nds1 ulc]s1 abscesses 4440 ,?is is a conflict ) ,rule #d4 ,! ,c\ncil held ,=mosol 9 conflict ) ,rules #d & #f1 & advis$ ! manufactur]s t ,=mosol is refus$ admission to ,new & ,non(ficial ,rem$ies until !y submit evid5ce e/abli%+ ! degree ( antiseptic & g]micidal effici5cy1 & ju/ify ! quotations li/$ above2 or until ^! & any o!r exi/+ conflicts ) ! ,rules h be5 remov$4 ,aft] submission ( ?is report to ,! ,=mosol ,*emical ,company ! ,c\ncil au?oriz$ its publication4--7,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiag1 p4 #ade47 ,,iodol5e1 ,a ,,solution ,,( ,,iod9 ,,9 ,,liquid ,,petrolatum1 ,,inadmissible ,,to ,n4 ,n4 ,r4 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil 0 ask$ to consid] a solution ( iod9 9 liquid petrolatum1 said to be prep>$ f ,gulf ,coa/ petroleum by a special process4 ,x 0 to be m>ket$ z 8,iodol50 provid$ ! ,c\ncil f\nd ! prep>ation admissible to ,new & ,non(ficial ,rem$ies4 ,! prep>ation 0 claim$ to conta9 ov] #a4e p] c5t4 free iod94 ,! foll[+ claims 7 made3 8,x is less irritat+ 9 its use on ! sk91 or 9 w\nds40 8,w kill pa?og5ic micro-organisms pres5t40 8,is a suitable m$ium = cell prolif]ation40 8,w p5etrate a useful di/ance into ! walls ( a w\nd40 8,facilitates an easi]1 less pa9ful & bett] me?od ( dress+ w\nds or ulc]s40 ,exam9ation 9 ! ,am]ican ,m$ical ,association ,*emical ,laboratory %[$ a submitt$ sample to conta9 #a4cb p] c5t4 free iod9 & to emit a /rong odor ( hydrog5 sulphid4 ,a specim5 ( liquid petrolatum1 said to be compos$ *iefly ( hydroc>bons ( ! naph!ne s]ies1 aft] saturation ) iod9 at room temp]ature 0 f\nd to conta9 #a4db p] c5t4 free iod94 ,ano!r specim5 ( liquid petrolatum1 said to be compos$ *iefly ( saturat$ hydroc>bons1 aft] saturation at room temp]ature 0 f\nd to conta9 #a4cj p] c5t4 free iod94 ,! prep>ation hav+ be5 %[n to be an unorig9al1 simple solution ( iod9 9 liquid petrolatum1 ! ,c\ncil decl>$ ! "n 8,iodol5e0 unacceptable 7,rule #h7 & ! !rapeutic claims made = ! prep>ation unw>rant$ 7,rule #f74--7;,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiag1 p4 #adh47 ,,kalak ,,wat] ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! foll[+ report1 submitt$ by a memb] ( ! ,c\ncil's committee on *emi/ry1 0 endors$ by ! committee & adopt$ by ! ,c\ncil3 ,kalak ,wat]1 sold by ! ,kalak ,wat] ,company1 ,inc41 ,new ,york1 is an artificial m9]al wat] said to be made by add+ c]ta9 salts to c>bonat$1 di/ill$ wat] & sup]saturat+ ) ! gas "u pressure4 ,su* m]it z x may possess by virtue ( sodium bic>bonate & sodium phosphate is q insuffici5t to w>rant ! extravagant claims made 9 ! adv]tis+ pamphlets4 ,accord+ to ! analysis furni%$1 ! wat] conta9s1 9 #a1jjj1jjj p>ts 7milligrams p] lit]7 ! foll[+3 ,sodium c>bonate #djdi4j ,sodium phosphate #bch4e ,sodium *loride #hjf4c ,calcium c>bonate #egh4b ,magnesium c>bonate #dh4i ,potassium *loride #dg4i ,among ! _m mislead+ /atem5ts f\nd 9 ! adv]tis+ pamphlet be>+ ! title 8,a ,brief = ,physiological ,alkalesc5ce0 ^! may be quot$3 8,! calcium cont5t ( ,kalak is ov] #ajj great] ?an ev] be=e plac$ 9 solution 9 any vehicle1 a fact ( supreme importance :5 ! unique alkal9iz+ p[] ( ! alkal9e salts ( ?is metal is consid]$2 ! ratio ( calcium metabolism to its enorm\s wa/e 9 pregnancy1 ! diseases ( infancy & *ildhood & ! rapidly gr[+ gr\p ( #8acidoses' make its availability 9 ,kalak ( d\ble value40 ,! fir/ "p ( ?is /atem5t is untrue2 ! la/ "p is muddl$ & )\t mu* mean+4 ,evid5tly ! 8acidosis0 fad is to be ov]work$ z 0 ! old 8uric acid dia!sis10 ( unsavory memory4 ,aga9 ?is3 8,"o ( ! mo/ important *>act]i/ics ( ,kalak is ! close approximation ( its =mula to ! correlation ( ! conta9$ salts z !y occur 9 ! human body1 toge!r ) its fre$om f salts =eign to ! human economy4 ,ano!r is its almo/ unbelievable palatability1 consid]+ its high degree ( alkal9ity1 x be+ elev5 times great] ?an any o!r kn[n m9]al wat]1 artificial or natural40 ,^! /atem5ts are false4 ,! salts dissolv$ "h be> no disc]nible relation to ! ne$s ( ! body1 z disclos$ by ! composition ( ! blood or solid tissues or z %[n by ! "* ( ! ur9>y excretion4 ,! la/ /atem5t conc]n+ ! high alkal9ity is nei!r cle> nor accurate4 ,!n1 ?is w>n+ & rem$y3 8,x seems to be an unappreciat$ fact t ! degree ( ur9>y acidity1 *eck$ ) ! acidity ( ! saliva1 is 9 direct ratio to ! exi/+ acid toxemia1 & a ur9e acid to me?yl r$ %\ld be ! signal = imm$iate & adequate alkal9iz+ treatm5t4444 8,/>tl+ cl9ical results h be5 obs]v$ by physicians :o h us$ ,kalak ?\ghtfully & suffici5tly 9 ! m s]i\s types ( acidosis associat$ ) diabetes1 nephritis1 rheumatism1 g\t & ! acute infections4 ,!re is also evid5ce ( its good effect 9 acute alcoholism & ! respiratory edemas2 9 fact a c]ta9 few h hail$ ,kalak z a possible solution ( ! annual hay fev] problem4 ,( p]haps supreme importance1 h[ev]1 is ! use ( ,kalak ?r\gh\t pregnancy z prev5tive m$ic9e aga9/ ! inevitable #8toxemia ( pregnancy4'0 ,also ?is3 8,kalak has accompli%$ c]ta9 unexpla9able ?+s = ! diabetic & nephritic1 & if1 9 future ye>s1 diabetes & nephritis %\ld prove to be con/itutional diseases1 bas$ ^u functionation or its lack1 ,kalak !rapy1 ! embodim5t ( physiological alkalesc5ce may come into its own1 = if acidity ret>ds1 alkal9ity mu/ normalize functionation40 ,x is n necess>y to quote fur!r4 ,9 ord] to insure t ev]yone w recognize ! great ne$ ( ,kalak x is advis$ to te/ ! ur9e = acidity by means ( a gr\p ( indicator solutions s5t out to ! physicians4 ,me?yl r$ is "o ( ^! & any ur9e %[+ an acid reaction ) ?is is said to be op5 to suspicion4 ,p>anitroph5ol is ano!r ( ! indicators & ! explanations giv5 ( ! behavior ( ! two & ! conclusions to be drawn are que/ionable4 ,! me?yl r$ solution furni%$ is too conc5trat$ = prop] use & p]fectly normal ur9es f normal individuals h giv5 a r m>k$ color ) x4 ,?is indicator gives "s color at ,h #a4b #aj-f & a /rong reaction at #c #aj-c4 ,to condemn a ur9e on su* a f9d+ is entirely unw>rant$4 ,sodium bic>bonate is ! ma9 con/itu5t ( ! wat]4 ,! value ( ! phosphate 9 su* a comb9ation1 ) s mu* calcium1 is problematical4 ,9 case an alkal9e reaction 9 ! inte/9e is rea*$ "s ( x w\ld be left z insoluble phosphate4 ,a few grams ( bic>bonate daily w\ld h equal !rapeutic value ) ?is wat]4 ,! advice bas$ on ! indications ( me?yl r$ & ! ur9e is bad4 ,! committee's report 0 s5t to ! ,kalak ,wat] ,company = comm5t4 ,! company promis$ to )draw ! adv]tis+ circul> ref]r$ to 9 ! report & disclaim$ responsibility = ! accuracy & value ( ! set ( indicators :i* x s5t out1 b1 on ! :ole1 ! previ\s adv]tis+ claims 7 insi/$ on4 ,9 view ( ! absurd & false claims made = ! product ! ,c\ncil decl>$ ,kalak ,wat] inadmissible to ,n4 ,n4 ,r4--7,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiag1 p4 #adh47 ,,m9son',s ,,soluble ,,iod9 8,,kelpid9e0 ,,n ,,admitt$ ,,to ,n4 ,n4 ,r4 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,m9son's ,soluble ,iod9 8,kelpid9e0 0 submitt$ to ! ,c\ncil by ,j4 ,j4 ,m9son1 ,wa%+ton1 ,d4 ,c41 trad+ z ! ,kelpid9e ,company1 ) ! /atem5t t 9 future 8lit]ature0 x 0 to be kn[n z ,m9son's ,soluble ,iod91 only4 ,! foll[+ /atem5t ( composition 0 furni%$3 8,m9son's ,soluble ,iod9 is some:at ( an indef9ite "*1 *emically4 ,its =mula is1 ,iod9 #d p] c5t41 ,di/ill$ ,wat] #f p] c5t41 & ,absolute ,alcohol q4 s4 #ajj p] c5t4 ,by a process ( *ill+ & heat+ an iodid ( unc]ta9 "* is produc$1 & because ( ! extreme s5sitiv5ess ( ! product to *emical te/s1 x is h>d to det]m9e4 ,s f> z ,i h be5 able to judge1 h[ev]1 ! result is ab\t #c or #c-a_/b p] c5t4 free iod9 & f #a_/b p] c5t4 to #a p] c5t4 iodid1 possibly e?yl & hydrog5 iodid 9 comb9ation40 ,! ,a4 ,m4 ,a4 ,*emical ,laboratory reports t ! prep>ation is an alcoholic solution conta9+ free iod9 & iodid1 probably hydrog5 iodid & e?yl iodid1 b t ! free iod9 cont5t 0 only #b4fi gm4 p] #ajj c4c4 ,x is claim$ t ! 8!rapeutic indications0 ( ,m9son's ,soluble ,iod9 are ! 8same z ^? ( all iod9 & iodid prep>ations1 int]nally1 ext]nally1 hypod]mically & intrav5\sly2 except+1 h[ev]1 c\nt] irritation40 ,x is admitt$ t !re are no 8cl9ical reports0 z to ! hypod]mic & intrav5\s use1 b ! belief is express$ 8t 9 an em]g5cy x is a safe rem$y "u prop] dilution40 ,x is fur!r claim$ t 8= all practical purposes x is nontoxic & nonirritat+0 & t 8x has none ( ! undesirable features su* z is ! case ) ! iodids & ! organic prep>ations ( iod91 propriet>y or o!rwise40 ,x 0 assign$ = consid]ation to ! ,committee on ,ph>macology1 ^: ref]ee report$3 8,accord+ to ! in=mation submitt$1 ?is is a t9cture ( iod92 diff]+ f ! (ficial t9cture 9 t x is m dilute & 9 t hydrog5 & e?yl iodid is ! solv5t 9 place ( potassium iodid4 ,x is practically immat]ial = int]nal adm9i/ration1 :e!r ! cation ( ! solv5t iodid is hydrog51 e?yl1 potassium or sodium4 ,x w\ld c]ta9ly be inadvisable to inject a prep>ation conta9+ free iod9 hypod]mically4 ,x is n #8a safe rem$y' = intrav5\s injection & x w\ld n be nonirritant4 ,! /atem5t t #8x has none ( ! undesirable features' ( o!r iod9 comp\nds is inh]5tly impossible4 ,app>5t fre$om ( any iod9 prep>ation f undesirable effects is g5]ally due to ! use ( small doses4 ,su* claims are pla9ly !rapeutic exagg]ations & !re=e 9 conflict ) ,rule #f4 ,ev5 %\ld ^! be remov$1 ! prep>ation mu/ be held an uness5tial modification ( ! (ficial t9cture1 & !re=e 9 conflict ) ,rule #aj40 ,! report 0 agre$ to by ! committee & adopt$ by ! ,c\ncil & ,m9son's ,soluble ,iod9 8,kelpid9e0 decl>$ inadmissible to ,new & ,non(ficial ,rem$ies4--7,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiag1 p4 #aeb47 ,,nutone ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,nu,tone 7,nu,tone ,company1 ,l[ell1 ,mass47 is a 8nutritive tonic0 said to h ! foll[+ complex composition3 ,cod ,liv] ,oil1 ,pure ,norwegian1 #be p] c5t4 ,malt ,extract1 #i-a_/c p] c5t4 ,beef juice1 ,glyc]9e1 ,hypophosphite ,lime1 ,hypophosphite ,soda1 ,*emically pure1 #a-a_/b grs4 ea* to ! oz4 ,fl4 ,ext4 ,nux ,vomica1 #c_/fd ( a m9imum 9 ea* teaspoonful4 ,x is adv]tis$ ) claims t w lead ?\ghtless physicians & a confid+ public to dep5d on x 9 cases 9 :i* fre% air1 hygi5ic surr\nd+s & nutriti\s food are ( prime importance4 ,a sample package 7! phrase 8z recomm5d$ by y\r physician0 & o!r /atem5ts sugge/ t x is expect$ to be giv5 ! pati5t by ! physician & ?us effectively adv]tise ,nu,tone to ! public7 describes ,nu,tone z an 8,agreeable ,conc5trat$ ,nutritive ,tonic ,emulsion ( ,malt ,extract1 ,beef ,juice & ,cod ,liv] ,oil1 ,comb9$ ) ,n]ve ,tonics & ,bone ,nutri5ts40 ,emphasiz+ ! nutritive value ( ?is 8,malt ,extract1 ,beef ,juice1 & ,cod ,liv] ,oil0 prep>ation1 x is advis$1 8,z ,nu,tone is ri* 9 nutritive prop]ties1 x is well to beg9 ) "o-f\r? teaspoonful1 gradually increas+ to regul> dose1 :i* is3 ,adults1 #a to #b teaspoonfuls aft] meals & at b$time4 ,*ildr5 accord+ to age40 ,x ?us appe>s t adults are to take ?is prep>ation z a 8nutritive0 9 doses :i* repres5t f #c to #ab gra9s ( sug> 7on ! assumption t malt extract may conta9 z mu* z #ej p] c5t4 sug>7 & #h to #cj m9ims ( cod liv] oil ) un/at$1 b probably equally small1 am\nts ( beef juice4 ,a consid]ation ( ! negligible food value ( ,nu,tone z well z ( ! ineffici5cy ( ! o!r compon5ts & ! claim t x is indicat$ 9 8malnutrition10 8wa/+ diseases0 & 8incipi5t ph?isis0 classes ,nu,tone ) t l>ge gr\p ( %otgun mixtures :i* d h>m 9 t dep5d5ce is plac$ on !m 9 conditions 9 :i* ! pati5t w probably be re/or$ to heal? if prop] m$ical & hygi5ic measures are adopt$ 9 "t4 ,! ,c\ncil decl>$ ,nu,tone inadmissible to ,new & ,non(ficial ,rem$ies because x is an irrational %otgun mixture adv]tis$ indirectly to ! public ) unw>rant$ !rapeutic claims & a nondescriptive !rapeutically sugge/ive "n4--7,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiag1 p4 #aed47 ,,tri-,,ars5ole1 ,l4 ,o4 ,,comp\nd ,,no4 #a ,,& ,l4 ,o4 ,,comp\nd ,,no4 #b ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,tri-,ars5ole4--,accord+ to ! adv]tis+ ( ! ,m$ical ,supply ,company ( ,atlanta1 ,ga41 8,tri-,ars5ole0 is 8,m]co-,ars5o-,b5zo-,*loride10 & ! claim is made3 8,?is comp\nd is ! result ( _m ye>s' rese>*4 ,! toxicity has be5 fully te/$ ^u animals be=e us+ cl9ically1 ! latt] hav+ prov5 su* complete success1 we take pleasure 9 pres5t+ x to ! public 4440 8,! manufactur]s ( ,,tri-,,ars5ol1 be=e plac+ x ^u ! m>ket1 te/$ x biologically40 ,tri-,ars5ole is 8recomm5d$ & suitable = ! treatm5t ( prim>y1 second>y1 t]ti>y & h]$it>y syphilis4 ,x has also be5 f\nd v useful 9 pellagra & mal>ia40 ,! prep>ation is suppli$ 9 ampules conta9+ v>y+ am\nts ( ! dry sub/ance4 ,x is to be dissolv$ 9 wat] & is to be adm9i/]$ intrav5\sly4 ,9 ! adv]tis+ att5tion is call$ to ! yell[ color ( ,tri-,ars5ole2 ?is1 & ! /yle ( package sugge/ t x is a prep>ation simil> to salv>san4 ,9 reply to a reque/ s5t ! ,m$ical ,supply ,company = ! quantitative composition & *emical =mula ( ! comp\nd 8,m]co-,ars5o-,b5zo-,*loride0 & = ! details ( ! biologic te/ by :i* its toxicity is claim$ to h be5 det]m9$ & evid5ce = its effici5cy1 ! foll[+ /atem5t 0 receiv$3 8,tri-,ars5ole ,no4 #a equals to ea* ,amp\le1 gr4 ,sodium *lorid #d-a_/b ,hydr>g *lor4-cor4 #a_/d ,ars5\s acid #a_/d ,sodium b5zoate #d ,hydra/9 7res9oid7 #b ,tri-,ars5ole ,no4 #b equals to ea* ,amp\le1 ,sodium *lorid #d ,hydr>g *lor4-cor4 #a_/b ,ars5\s acid #a_/b ,sodium b5zoate #d ,hydra/9 7res9oid7 #b ,tri-,ars5ole ,no4 #c equals to ea* ,amp\le1 ,sodium *lorid #c-a_/b ,hydr>g *lor4-cor4 #c_/d ,ars5\s acid #c_/d ,sodium b5zoate #d ,hydra/9 7res9oid7 #b ,tri-,ars5ole ,no4 #d equals to ea* ,amp\le1 ,sodium *lorid #c ,hydr>g *lor4-cor4 #a ,ars5\s acid #a ,sodium b5zoate #d ,hydra/9 7res9oid7 #b ,! reque/ = in=mation reg>d+ ! animal exp]im5ts said to h det]m9$ ! toxicity 0 ignor$1 nor 7 ref]5ces suppli$ to cl9ical reports demon/rat+ ! value ( ! product4 ,! ,c\ncil decl>$ ,tri-,ars5ole inadmissible to ,new & ,non(ficial ,rem$ies because ( conflict ) ! rules z foll[s3 ,9 ! abs5ce ( details ( ! me?od us$1 ! claim t ! prep>ation has be5 te/$ biologically is 9 conflict ) ,rule #b1 :i* requires t = prep>ations claim$ to be physiologically /&>diz$ ! me?od ( te/+ mu/ be publi%$ s z to p]mit ( control by indep5d5t inve/igators4 ,! claims t 8,m]co-,ars5o-,b5zo-,*loride0 is 8! result ( _m ye>s rese>*10 t its 8toxicity has be5 fully te/$ ^u animals be=e us+ cl9ically0 & t cl9ical use has 8prov5 su* complete success0 h n be5 sub/antiat$ by evid5ce & mu/ be held z unw>rant$4 ,! "n is 9 conflict ) ,rule #h1 :i* requires t ph>maceutical mixtures %all be> names descriptive ( _! composition4 ,fur!r1 ! "n 8,tri-,ars5ole0 by its simil>ity to ,di>s5ol1 ! ,canadian br& ( ars5o-ph5olam9 hydro*lorid1 sugge/s t ?is ph>maceutical mixture is a *emical comp\nd simil> to salv>san4 ,moreov]1 ! dang] ( confusion is increas$ by ! addition ( ! hydra/is prep>ation :i* imp>ts a yell[ color l t ( salv>san to ! solution obta9$ :5 ! colorless m]cury & ars5ic comp\nds ( ! mixture are dissolv$4 ,aga91 ! synonym 8,m]co-,ars5o-,b5zo-,*loride0 conveys ! false impression t ,tri-,ars5ole is a def9ite *emical comp\nd4 ,! label does n decl>e ! poison\s con/itu5ts claim$ to be conta9$ 9 ! mixture2 namely1 8ars5\s acid0 & corrosive m]curic *lorid 7,rule #g74 ,!re is no evid5ce t ars5\s acid 7ars5ic trioxid7 us$ intrav5\sly is effici5t & safe z a spiro*eticide1 & ! adm9i/ration ( ?is drug 9 conjunction ) m]curic *lorid 9 fix$ proportion is irrational & dang]\s--p>ticul>ly s because ( ! impli$ simil>ity ( ,tri-,ars5ole to ars5ph5olam9 hydro*lorid 7,salv>san1 ,di>s5ol7 7,rule #aj74 ,l4 ,o4 ,comp\nd ,no4 #a & ,l4 ,o4 ,comp\nd ,no4 #b4--;,9 submitt+ ^! prep>ations to ! ,c\ncil1 ! ,m$ical ,supply ,company /at$ t 8,no4 #a0 0 8compos$ ( ! foll[+ +r$i5ts2 *loral1 camphor1 m5?ol1 iod91 & oil ( gual!ria1 incorporat$ 9 a fatty base4 ,ea* ounce conta9s fifte5 gra9s ( *loral hydrate1 n9e gra9s ( resublim$ iod9e40 8,no4 #b0 0 said to h ! same composition z 8,no4 #a0 except t ! oil ( gaul!ria _h be5 omitt$4 ,! ,m$ical ,supply ,company 0 in=m$ t ! rules ( ! ,c\ncil requir$ decl>ation ( ! am\nts ( ea* !rapeutic con/itu5t ( ph>maceutical mixtures & t1 !re=e1 9 addition to ! in=mation furni%$ ! am\nts ( camphor1 m5?ol & oil ( gual!ria %\ld be giv5 = 8,no4 #a0 & ! am\nt ( camphor & m5?ol = 8,no4 #b40 ,! foll[+ reply 0 receiv$3 8,l4 ,o4 ,comp\nd ,no4 #a equals to ea* ,tube1 ,*loral hydrate gr4 #ae ,camphor gr4 #bb ,m5?ol gr4 #g-a_/b ,iod9 7resublime7 gr4 #c-b_/c ,oil ( gaul!ria m4 #c ,petrolatum1 q4 s4 oz4 #a ,l4 ,o4 ,comp\nd ,no4 #b1 ,! same z above =mula = ,l4 ,o4 ,c4 ,no4 #a1 except ! oil ( gaul!ria :i* is omitt$40 ,x %\ld be not$ t :5 ! prep>ations 7 submitt$ ea* ounce ( ! prep>ation 0 claim$ to conta9 #i gra9s ( iod91 :ile 9 ! subsequ5t lett] ! company decl>es t !y conta9 only #c-b_/c gra9s to ! ounce4 ,if x be assum$ t ! unit int5d$ is ! avoirdupois ounce1 ! prep>ation %\ld conta9 #b4jf p] c5t4 ( iod9 accord+ to ! fir/ /atem5t & #j4hd p] c5t4 ( iod9 accord+ to ! second /atem5t4 ,:ile ! d>k color ( ! prep>ations sugge/$ ! pres5ce ( appreciable am\nts ( free iod91 ! ,a4 ,m4 ,a4 ,*emical ,laboratory report$ t an exam9ation ( ! specim5s submitt$ by ! ,m$ical ,supply ,company %[$ t 8,no4 #a0 & 8,no4 #b0 ea* conta9$ b #j4jcc p] c5t4 ( free iod92 h5ce bo? prep>ations are 9 conflict ) ,rule #a4 ,= bo? prep>ations ! labels sugge/ _! use = ! treatm5t ( 8septic w\nds1 burns1 pu/ul> processes ( all v>ieties1 & especially bron*ial tr\bles40 ,?is con/itutes a conflict ) ,rule #d4 ,reg>d+ ,no4 #a ! adv]tis+ circul> includ$ ) ! trade package ass]ts3 8,its m]its h be5 practically demon/rat$ 9 ! foll[+ conditions4 ,we invite y\r especial att5tion to its use 9 diseases ( ! ?oracic cavity1 especially ,bron*itis & ,pneumonia1 ,rheumatism1 ,lumbago1 ,migra9e1 ,neuralgia1 ,or*itis1 ,balanitis1 enl>g$ gl&s or any di/urbance ( ! lymphatic sy/em1 anti-galactagogue1 or :]ev] analgesic action is requir$40 8,no4 #b0 is said to be especially adapt$ to ! ne$s ( ! surgeon1 x 8c be appli$ 9 any w\nd ei!r aseptic or infect$40 ,x is ass]t$ t ! usual me?od ( prep>+ pati5ts = op]ation may be disc>d$ & t pati5ts may be op]at$ on aft] application ( ?is o9tm5t3 8444 ,we h no o!r prep>ation to-day :i* s]ves ! purpose ( ,l4 ,o4 ,comp\nd 9 op]ative & po/ op]ative treatm5t4 8,x is a p[]ful antiseptic & g]micide comb9+ ane/hetic1 analgesic & alt]ative prop]ties40 ,aft] attempt+ to discr$it ! approv$ me?ods ( prep>+ ! field = surgical op]ations1 ! adv]tis+ circul> cont9ues3 8,me?od ( today3 ,a lib]al am\nt ( ,l4 ,o4 ,comp\nd ,no4 #b is appli$ to ! int5d$ area ( op]ation1 massage ?or\ghly until absorption is complete4 ,pati5t is ready = op]ation 4440 ,bo? products are 9 conflict ) ,rule #f4 ,fur!r1 z ! names ( ^! ph>maceutical mixtures are n descriptive ( _! composition1 !y also conflict ) ,rule #h4 ,! use ( complex mixtures su* z ^! is irrational & leads to misplac$ confid5ce on ! "p ( ! physician2 p>ticul>ly :51 z 9 ?is case1 nei!r ! label nor ! adv]tis+ matt] gives ! necess>y in=mation reg>d+ ! composition ( ! prep>ations fur!r ?an t1 9 accordance ) ! requirem5ts ( ! ,f$]al ,food & ,drugs ,act1 ! am\nt ( *loral is decl>$ 7,rule #aj74 ,! ,c\ncil decl>$ ,l4 ,o4 ,comp\nd ,no4 #a & ,l4 ,o4 ,comp\nd ,no4 #b inadmissible to ,new & ,non(ficial ,rem$ies = conflict ) ,rules #a1 #d1 #f1 #h & #aj4 ,! ,c\ncil's consid]ation ( ,tri-,ars5ole1 ,l4 ,o4 ,comp\nd ,no4 #a & ,l4 ,o4 ,comp\nd ,no4 #b 0 bas$ on in=mation receiv$ f ! ,m$ical ,supply ,company1 ! correspond5ce be+ sign$ 8,m$ical ,supply ,co41 p] ,dr4 ,h4 ,e4 ,pontius40 ,! f9d+s hav+ be5 s5t to ! ,m$ical ,supply ,company1 ! foll[+ reply 0 receiv$3 7,june #bg1 #aiag7 8,reply+ to y\r regi/]$ lett] ( ?is ,a4 ,m4 relative to ! ,m$ical ,supply ,company's products1 w /ate t ! p>ty furni%+ y ) su* in=mation z y h 9 h& 0 mis9=m$4 ,he is no long] ) ?is company & :]eab\ts unkn[n4 ,respectfully1 ,m$ical ,supply ,company1 7,sign$7 ,w4 ,b4 ,l+o1 ,presid5t40 ,! ,m$ical ,supply ,company !n 0 ask$ to po9t out any /atem5ts occurr+ 9 ! report1 z submitt$1 :i* ! company consid]$ to be inaccurate2 b no reply has be5 receiv$ to ?is reque/4 ,! adv]tis+ s5t out by ! ,m$ical ,supply ,company dur+ ! la/ "p ( ,augu/ conta9$ ess5tially ! same /atem5ts & claims z ^? to :i* ref]5ce is made 9 ! prec$+ report4 ,a qualitative exam9ation ( ,tri-,ars5ole made 9 ! ,a4 ,m4 ,a4 ,*emical ,laboratory indicat$ ! pres5ce ( sodium1 m]cury1 ars5ic1 *lorid1 b5zoate & a hydra/is prep>ation4 ,quantitative det]m9ations 7 n made z !re 0 no gu>antee t an analysis ( ! pres5t supply w\ld indicate ! composition ( t m>ket$ lat] on4 ,9 view ( ! /atem5t ( ! presid5t ( ! company1 t ! in=mation submitt$ 9 ! lett]s f ! ,m$ical ,supply ,company 0 inaccurate1 ,tri-,ars5ole & ,l4 ,o4 ,comp\nd mu/ def9itely be plac$ ) prep>ations1 ! composition ( :i* is n divulg$ by _! own]s2 h5ce ,tri-,ars5ole z well z ,l4 ,o4 ,comp\nd ,no4 #a & ,l4 ,o4 ,comp\nd ,no4 #b are 9 conflict ) ,rule #a4--7;,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiag1 p4 #aef47 ,,unctol ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,unctol1 sold by ! ,r4 ,r4 ,rog]s ,*emical ,company1 ,san ,francisco1 is a pa/e /at$ to conta9 approximately #dj p] c5t4 ( metallic m]cury 9 a soap base4 ,x is claim$ t a "p ( ! m]cury is 8precipitat$ m]cury0 & a "p 8me*anically comm9ut$ m]cury40 ,unctol is sold z a sub/itute = m]curial o9tm5t & is to be rubb$ into ! sk9 ) ! aid ( wat]4 ,! claim is made = ,unctol t 8,x is m active ?an blue o9tm5t because ! m]cury 9 x 7#dj p] c5t47 is m f9ely divid$ & ! la!r+ /ill fur!r subdivides ! m]cury p>ticles & h5ce promotes absorption40 ,no evid5ce 0 pres5t$ to ! ,c\ncil 9 support ( ! claim$ sup]ior efficacy ( m]cury soap pa/e ov] ! (ficial m]curial o9tm5t4 ,on ! o!r h&1 a consultant ( ! ,c\ncil :o has /udi$ ! absorption ( m]cury & m]cury comp\nds1 :5 appli$ to ! sk91 report$ t he _h us$ m]cury prep>ations 9 :i* soap 0 ! base1 & t 9 8 op9ion ,unctol c\ld h no advantage ov] ! (ficial m]curial o9tm5t f ! /&po9t ( !rapeutic effect4 ,moreov]1 ! ,c\ncil is advis$ t "s trials ) ,unctol at ! sk9 cl9ic ( ,lel& ,/an=d ,univ]sity ,junior ,s*ool ( ,m$ic9e did n confirm ! claim t ,unctol is m active ?an m]curial o9tm5t4 ,! ,c\ncil decl>$ ,unctol inadmissible to ,new & ,non(ficial ,rem$ies because3 #a4 ,! claim ( sup]iority ov] m]curial o9tm5t is n sub/antiat$1 & con/itutes an unw>rant$ !rapeutic claim 7,rule #f74 #b4 ,! "n does n indicate ! composition ( ?is ph>maceutical mixture 7,rule #h74 #c4 ,! circul> wrapp$ ) ! trade package adv]tises propriet>y prep>ations n accept$ by ! ,c\ncil 7,rule #d74--7;,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiag1 p4 #afb47 ,v-,e-,m 7,,s*oonmak] ,,laboratories1 ,,inc47 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,because ( inquiry receiv$1 ! ,s*oonmak] ,laboratories1 ,inc41 ,new ,york1 7 reque/$ to submit in=mation 9 reg>d to ! 8,v-,e-,m0 products4 ,accord+ to in=mation receiv$1 ^! products h ! foll[+ composition3 ,v-,e-,m ,ungu5tum ,eucalyptol ,comp\nd ,m5?ol #e grs4 ,eucalyptol 7,s&]'s7 #ae gtts4 ,:ite ,vasel9e #a oz4 ,v-,e-,m ) ,i*?yol ,m5?ol #b-a_/b grs4 ,eucalyptol 7,s&]'s7 #ae gtts4 ,i*?yol #aj grs4 ,:ite ,vasel9e #a oz4 ,v-,e-,m ) ,/e>ate ( ,z9c ,m5?ol #b-a_/b grs4 ,eucalyptol 7,s&]'s7 #ae gtts4 ,/e>ate ( ,z9c #a drm4 ,:ite ,vasel9e #a oz4 ,v-,e-,m ) ,camphor ,camphor #ae grs4 ,eucalyptol 7,s&]'s7 #ae gtts4 ,:ite ,vasel9e #a oz4 ,v-,e-,m ) ,boric ,acid ,pulv4 ,boric ,acid #a_/b drm4 ,eucalyptol 7,s&]'s7 #ae gtts4 ,:ite ,vasel9e #a oz4 ,9 an adv]tis+ circul> ?is claim is made3 8,v-,e-,m ,ungu5tum ,eucalyptol ,comp\nd ,comb9+1 9 well-balanc$ proportions1 ! cool+1 soo?+ & heal+ virtues ( ,m5?ol ) ! antiseptic & deodoriz+ prop]ties ( ,eucalyptol1 9 a base ( pure1 neutral :ite ,vasel9e4 ,furni%$ 9 five =mulas z foll[s3 8,v-,e-,m ,ungu5tum ,eucalyptol ,comp\nd3 ,m5?ol1 ,eucalyptol 7,s&]'s71 ,:ite ,vasel9e4 8,v-,e-,m ) ,i*?yol3 ,m5?ol1 ,eucalyptol 7,s&]'s71 ,i*?yol1 ,:ite ,vasel9e4 8,v-,e-,m ) ,/e>ate ( ,z9c3 ,m5?ol1 ,eucalyptol 7,s&]'s71 ,/e>ate ( ,z9c1 ,:ite ,vasel9e4 8,v-,e-,m ) ,camphor3 ,camphor1 ,eucalyptol 7,s&]'s71 ,:ite ,vasel9e4 8,v-,e-,m ) ,boric ,acid3 ,pulv4 ,boric ,acid1 ,eucalyptol 7,s&]'s71 ,:ite ,vasel9e4 8,= local application 9 ! treatm5t ( affections ( ! nose & ?roat4 8,! efficacy ( ^! comb9ations ( rem$ial ag5ts is s well e/abli%$ z to preclude ! necessity ( m ?an pass+ m5tion4 ,:at is obvi\s is t 9 acute coryza1 9 *ronic & acute nasal cat>rh1 9 dry cat>rhal conditions especially1 9 bo? =ms ( *ronic rh9itis--atrophic & hyp]trophic--9 ! latt] /ages ( ! prevail+ grippe colds1 & ev5 9 hay fev]1 ,v-,e-,m ,ungu5tum ,eucalyptol ,comp\nd af=ds pron\nc$ relief & proves a mo/ grateful application44440 ,?\gh ! id5tity & purity ( eucalyptol are provid$ = by ! /&>ds ( ! ,u4 ,s4 ,ph>macopeia1 ! claim is made t ! product conta9$ 9 ^! prep>ations 8transc5ds 9 purity & effici5cy all o!r br&s40 ,a package ( ,v-,e-,m ,ungu5tum ,eucalyptol ,comp\nd1 rec5tly s5t to a physician1 conta9s ! foll[+3 8,if y\r head is all /uff$ up to-night1 or y feel a cold com+ on1 use ,v-,e-,m j be=e go+ to b$4 ,x w break up ! cold1 & y'll wake up 9 ! morn+1 ) y\r head cle> & feel+ f9e all ov]4 8,if y suff] ) *ronic or acute cat>rh1 use ,v-,e-,m regul>ly night & morn+4 ,y'll be agreeably surpris$ at ! relief x w give y 9 a %ort "t4 8,!re is no?+ quick]1 no?+ sur] to alleviate rh9itis1 grippe-colds1 or hay fev]4 8,9 a ^w--,v-,e-,m is ! be/ antiseptic o9tm5t = all diseas$ conditions ( ! nose44440 ,! ,c\ncil decl>$ ^! prep>ations 9 conflict ) its rules because unw>rant$ !rapeutic claims 7 made = !m 7,rule #f72 because ! public 0 advis$ to dep5d on !m 9 ! treatm5t ( diseases 7,rule #d71 & because ^! comb9ations ( +r$i5ts1 9 fix$ proportions1 "u propriet>y names1 are irrational 7,rules #h & #aj74--7;,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiag1 p4 #afc47 ,,hemo-,,!rap9 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! foll[+ report on ,hemo-,!rap9 has be5 adopt$ by ! ,c\ncil1 & its publication au?oriz$4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,accord+ to ! ,hemo-,!rap9 ,laboratories ( ,new ,york ,city3 8,hemo-,!rap9 is a comb9ation ( highly ref9$ creosols & ph5ols 7:i* h be5 detoxicat$ by special processes7 ) salts ( iron1 potassium1 sodium1 phosphorus & calcium 9 m9ute b physiologic proportions--! solution z a :ole be+ design$ to approximately closely 9 v>i\s fundam5tal details ! *emi/ry ( ! blood40 ,no /atem5t is made z to ! quantities ( ! sev]al +r$i5ts1 nor is any in=mation giv5 z to ! id5tity ( ! 8creosols0 & 8ph5ols10 nor ! nature ( ! processes :]eby ^! are 8detoxicat$40 ,x is fur!r claim$ t x is3 8444 ,! composite "* ( ,hemo-,!rap91 ! relative proportion & balance ( its sev]al +r$i5ts1 & ! action ( ! comp\nd z a :ole1 to :i* its pot5cy is due40 ,& x is sugge/$ t3 8,x w be app>5t t ! +r$i5ts :i* ent] into ! composition ( ,hemo-,!rap91 a rem$y us$ intrav5\sly exclusively1 h be5 select$ ) ! utmo/ c>e ) ! object ( assur+ n only maximum !rapeutic pot5cy b also absolute safety & fre$om f all dang]s ( toxic or o!r unpleasant or h>mful action40 ,italics 9 ! orig9al4 ,! adv]tis+ does n expla91 h[ev]1 :y ! complex prep>ation %\ld be !rapeutically effici5t or :y ! intrav5\s adm9i/ration ( ?is mixture %\ld be absolutely safe & free f toxic or h>mful action4 ,( ! orig9 ( ,hemo-,!rap9 x is said3 8,= _m ye>s ,dr4 ,e4 ,b4 ,witte1 a prom95t physician ( ,tr5ton1 ,n4 ,j4 app>5tly own] ( ! ,hemo-,!rap9 ,laboratories has devot$ himself to ! /udy ( ! blood4 ,z a result ( 8 rese>*es1 he e>ly det]m9$ t :5 ! blood is close to normal /&>ds1 ! body is well n\ri%$1 ! natural wa/e products are prop]ly elim9at$1 an effective resi/ance is (f]$ to ! invasion ( pa?og5ic bact]ia1 & ! v>i\s functions ( ! body are kept normally active4 ,b :51 = "o reason or ano!r1 ! blood falls away f normal /&>ds1 ! nutrition ( ! body suff]s1 ! elim9ation ( wa/e products is impair$1 ! resi/ance to g]m attack is weak5$1 & ! v>i\s functions ( ! body become sadly d]ang$ & p]v]t$4 ,9 o!r words1 in/ead ( ! physiologic processes ( ! body be+ normally active1 z soon z ! blood is depreciat$1 !y become depress$ or d]ang$1 ) a loss ( ! physiologic h>mony or equilibrium t con/itutes a /ate ( heal?4 8,recogniz+ ! relation ( cl9ical conditions to ^! v>i\s ph5om5a1 ,dr4 ,witte rea*$ ! conclusion t ! correction ( _m ab]rant or diseas$ conditions dep5d$ on re/or+ ! blood to z ne> to its normal /ate z possible4 ,he accord+ly appli$ himself especially to inve/igation ( ! *emi/ry ( ! blood1 ) ! object ( evolv+ a sub/ance 9 liquid =m t w\ld s closely approximate normal blood 9 its ess5tial *emical *>act]i/ics t :5 introduc$ into ! circulation x w\ld br+ ! blood ne>] to ! condition 9 :i* x exi/s 9 heal?40 ,aft] ! usual 8_m ye>s ( h>d pa9/ak+ labor10 ,dr4 ,witte elaborat$ a 8fluid meet+ ! =ego+ conditions0 & n[ ! ,hemo-,!rap9 ,laboratories in=m u t #e to #aj c4c4 ( ?is syn!tic blood adm9i/]$ once 9 "o1 two or ?ree days 9 8acute affection0 & at long] int]vals 9 8*ronic ills0--once a week is said to be usually suffici5t--w re/ore blood to a normality & emp[] x to ov]come mo/ ills4 ,:ile disclaim+ t 8,hemo-,!rap9 is an infallible panacea10 ! m$ical pr(ession is ask$ to believe t3 8,9 erysipelas1 septicemia1 pyemia1 ! acute fev]s1 pu]p]al infection1 furunculosis1 c>buncles1 mal>ia1 acute rheumatism1 pneumonia1 typhoid fev]1 & 9 v>i\s sk9 diseases1 su* z eczema1 psoriasis1 h]pes zo/]1 etc41 ! results h be5 prompt & gratify+40 ,x is 8no less effective0 9 su* 8*ronic ailm5ts0 z3 8444 diabetes1 *ronic ,bright's disease1 goit]1 pulmon>y tub]culosis1 *ronic rheumatism1 ! sev]e anemias1 art]io-scl]osis sic1 v>i\s n]v\s disord]s1 locomotor ataxia1 v>icose & indol5t ulc]s44440 ,evid5ce ( ! virtues ( ,hemo-,!rap9 is submitt$ z a s]ies ( 8case reports0--unsign$--:i* be> a /rik+ lik5ess to ! te/imonials ( 8pat5t m$ic9e0 almanacs4 ,a specim5 ( ! 8case reports0 is ! foll[+3 8,blood ,poison+ due to ,snake ,bite4--,case #i43 ,mrs4 ----2 age1 #eb2 0 bitt5 by a poison\s snake--a copp]head--sev5te5 ye>s ago4 ,on ! anniv]s>y ( ! bite ! arm w\ld swell to m ?an twice its normal size & !re w\ld be pa91 *ills & fev]4 ,aft] a mon? ( ?is ! acute symptoms w\ld disappe> & ! arm w\ld %[ l>ge scaly blot*es :i* ^u be+ remov$ w\ld disclose a ?9 muc\s liquid4 ,?r\gh\t ! sev5te5 ye>s pa9 0 con/ant1 be+ p>ticul>ly acute 9 midsumm] ar\nd ! anniv]s>y ( ! bite4 ,?is pati5t _h consult$ _m physicians dur+ ! sev5te5 ye>s ( suff]+ )\t any relief4 ,l>ge doses ( n>cotic rem$ies 7 necess>y ea* day to subdue ! pa94 ,tw5ty-f\r h\rs aft] ! fir/ injection ( ,hemo-,!rap9 all pa9 0 dissipat$4 ,aft] f\r treatm5ts ! pati5t 0 consid]$ well & !re has be5 no return ( any ( ! symptoms s9ce ! la/ treatm5t six mon?s ago40 ,hemo-,!rap9 is sold 9 ampules3 #f = #e & #ab = #aj1 & a circul> s5t to a physician conta9$ ?is typewritt5 note3 8,,fees4--,:ile ! physician's fee is n regulat$ by ?is company1 ! physicians :o use ,hemo-,!rap9 get #e4jj & #aj4jj = ea* treatm5t40--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #e1 #aiah47 ,,v5osal ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! foll[+ report on ,v5osal has be5 adopt$ by ! ,c\ncil1 & its publication au?oriz$4 ,w4 ,a4 ,puckn]1 ,secret>y4 8,v5osal0 is "o ( ! products ( ! ,intrav5\s ,products ,company1 ,d5v]1 ,colo4 ,its composition has be5 v>i\sly1 & obscurely1 describ$3 8,v5osal is a /]ile solution repres5t+ #a gm4 7#ae4d gr47 ( salicylates 9 comb9ation1 toge!r ) col*icum40 8,?is is a product = intrav5\s use4 ,! composition ( :i* is ,sodium ,salicylate1 #ae4d grs4 7#a gm471 ,iron ,salicylate a m9ute quantity & ! equival5t ( approximately #b grs4 ,dri$ ,col*icum ,root40 ,none ( ^! 8=mulas0 gives ! quantity ( ! product conta9+ ! #a gm4 ( salicylate1 etc41 b presumably x ref]s to ! cont5ts ( #a ampule or #bj c4c4 ,?is inf]5ce is 9 accord ) ! analysis ( ! product made 9 ! ,*emical ,laboratory ( ! ,am]ican ,m$ical ,association4 ,! analysis also br\ght out ! fact t ! am\nt ( iron 9 a giv5 ampule 0 #j4jjjh gm4 7ab\t #a_/hj gra974 ,?is trace ( iron 9 ! pres5ce ( salicylate gives ! product a purple color4 ,v5osal is recomm5d$ = ! treatm5t ( 8rheumatism10 mean+1 ! context w\ld indicate1 infecti\s rheumatic fev]4 ,z col*icum has no special action on ?is disease & z !re is no app>5t reason = ! employm5t ( ! trace ( iron pres5t1 ^! additions 9 fix$ proportions are unsci5tific1 if n absurd4 ,accord+ to ! adv]tis+ matt]3 8,v5osal 444 elim9ates unpleasant dige/ive di/urbances :i* frequ5tly =bid ! use ( salicylates by m\? &1 9 addition1 insures _! full !rapeutic value40 ,! /atem5t is mislead+1 z ! cases 9 :i* ! oral adm9i/ration ( ! salicylates is contra9dicat$ are n 8frequ5t0 b exceptional & !re is no evid5ce to ju/ify ! implication t ! 8full !rapeutic value0 ( salicylates _c readily be atta9$ by _! oral use4 ,/ill m a/oni%+ is ! foll[+ claim3 8,v5osal is a comb9ation c>ry+ ! true salicylates 7sodii7 9 doses mu* l>g] ?an giv5 by m\?4 ,) ?is prep>ation giv5 intrav5\sly1 !re is no nausea or disagreeable dige/ive aft]-effects1 t9nitus aurium1 or ! accumulat+ effects ( ! drug2 yet ! specific action ( ! salicylates seems to be increas$ _m-fold1 accord+ to reports receiv$40 ,:at are ! facts8 ,by m\? sodium salicylate is giv5 9 doses ( f #c to #ae gm4 9 a day2 :]eas ,v5osal is advis$ z #a gm41 9 f "o to ?ree day int]vals2 z a matt] ( elem5t>y ari?metic x is pla9 t ^! doses ( ,v5osal are small] in/ead ( be+ 8mu* l>g]40 ,! abs5ce ( dige/ive ill effects1 t9nitus1 etc41 is expla9$ by ! small dosage4 ,t ! specific action ( ! salicylates %\ld be increas$ by intrav5\s adm9i/ration is surpris+ :5 x is rememb]$ t ! drug is absorb$ rapidly & completely f ! inte/9es2 9 fact1 ! quot$ /atem5t is incr$ible4 ,! company fur!r alleges t1 on ! basis ( 8cl9ical reports0 x has receiv$1 x does n 8hesitate to recomm5d ?is product = r\t9e use 9 all /reptococcic infections40 ,su* a !rapeutic sugge/ion is1 to put x cons]vatively1 gross exagg]ation4 ,! :ole "q ( ! ju/ification ( us+ salicylates intrav5\sly is op5 to grave d\bt4 ,s9ce x is possible to obta9 ! salicylate effects promptly & c]ta9ly by oral adm9i/ration1 ! inh]5t dang]s ( intrav5\s m$ication r5d] its r\t9e employm5t unw>rant$4 ,a fur!r objection to ,v5osal1 especially at ?is "t :5 economy is a national policy1 is ! unnecess>ily high exp5se ( ,v5osal itself & ( its adm9i/ration4 ,! ref]ee recomm5ds t ,v5osal be decl>$ ineligible to ,new & ,non(ficial ,rem$ies because ( conflicts ) ,rule #a 7indef9ite *emical composition71 ,rule #f 7!rapeutic exagg]ations7 & ,rule #aj 7unsci5tific composition74--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #e1 #aiah47 ,,secret9-,,bev]idge ,,& ,,! ,u4 ,s4 ,,pat5t ,,law ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,two ye>s ago ! ,c\ncil publi%$ reports on two propriet>y prep>ations said to conta9 secret91 namely1 8,secretog510 sold by ! ,g4 ,w4 ,c>nrick ,company 7,! ,j\rnal ,a4 ,m4 ,a41 ,may #a1 #aiae1 p4 #aeah71 & 8,duod5910 sold by ,arm\r & ,company 7,! ,j\rnal ,a4 ,m4 ,a41 ,aug4 #ad1 #aiae1 p4 #fci74 ,^! reports expla9$ t !re 0 no evid5ce to indicate t an insuffici5t am\nt ( secret9 0 ! cause ( ga/ro-inte/9al diseases1 & fur!r t !re 0 no evid5ce t secret9 9 any =m 0 physiologically active :5 adm9i/]$ by ! m\?4 ,subsequ5tly1 ,a4 ,j4 ,c>lson & 8 co-work]s1 at ! reque/ ( ! ,c\ncil1 /udi$ ! "q ( ! /ability ( secret9 & demon/rat$ 7,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #ae1 #aiaf1 pp4 #agh & #bjh7 t comm]cial secret9 prep>ations conta9$ no secret9 &1 fur!r1 t secret9 giv5 bo? by ! m\? & ev5 9 enorm\s doses directly into ! inte/9e is entirely inactive4 ,%ortly aft] ! publication ( ,pr(essor ,c>lson's "w ! att5tion ( ! ,c\ncil 0 call$ to a ,u4 ,s4 pat5t issu$1 ,may #b1 #aiaf1 to ,james ,wallace ,bev]idge1 8,means = & ,me?od ( ,/abiliz+ ,secret940 ,9 ?is pat5t ,bev]idge claim$ to h inv5t$ 8,! process ( produc+ secret9 9 /able =m z a comm]cial article = !rapeutic use 4440 t is1 a process = prep>+ prep>ations :i* w\ld conta9 secret9 :5 !y rea* ! consum] & 9 a =m resi/+ de/ruction 9 its passage ?r\gh ! /oma*4 ,9 view ( ! demon/rat$ in/ability ( secret91 ! ,c\ncil ask$ ,pr(essor ,c>lson to inve/igate ! validity ( ! claims ( ! ,bev]idge pat5t4 ,! /udy on 8,! ,"q ( ! ,/ability ( ,secret910 by ,a4 ,j4 ,c>lson1 ,a4 ,e4 ,kant] & ,i4 ,tump[ski1 :i* appe>s bel[1 %[s t ! ,bev]idge pat5t furni%es no process = ! manufacture ( comm]cially /able secret9 prep>ations1 nor any means = prev5t+ ! de/ruction ( secret9 by ! ga/ric juice :5 adm9i/]$ orally4 ,x fur!r demon/rates t ! prep>ation made by ,bev]idge 0 devoid ( secret94 ,! ,c\ncil adopt$ ! report ( ,c>lson & 8 co-work]s1 & decl>$ ,secret9-,bev]idge inadmissible to ,new & ,non(ficial ,rem$ies4 ,! ,c\ncil direct$ t ! report ( ,c>lson & 8 collaborators be s5t to ! ,commission] ( ,pat5ts ) a prote/ aga9/ ! grant+ ( pat5ts )\t compet5t & ?or\gh inve/igation ( ! claims advanc$ !re94 ,w4 ,a4 ,puckn]1 ,secret>y4 ,,! ,,"q ,,( ,,! ,,/ability ,,( ,,secret9 ,a4 ,j4 ,c>lson1 ,a4 ,e4 ,kant] & ,i4 ,tump[ski ,f ! ,hull ,physiological ,laboratory ( ! ,univ]sity ( ,*icago ,9 a lett]s pat5t1 fil$ ,may #f1 #aiad1 ! pat5t grant$ ,may #b1 #aiaf1 ,james ,w4 ,bev]idge1 ,m4,d41 makes c]ta9 claims conc]n+ ! /ability & physiologic activity ( secret9 prep>$ accord+ to ! me?od pat5t$ by him4 ,9 brief1 ,dr4 ,bev]idge claims t secret9 prep>$ by dige/+ inte/9al mucosa ) a weak acid at a temp]ature slightly bel[ boil+1 & mix$ ) #j4b p] c5t4 to #b p] c5t4 blood s]um1 album9 or peptone 7#a7 rema9s active = at lea/ six mon?s1 7#b7 /imulates ! pancreas :5 giv5 by m\?1 & 7#c7 8may be inject$ intrav5\sly 9 man1 if desir$40 ,! only ?+ 9 ! lett]s pat5t 9 support ( ^! claims is ! /atem5t3 8,i h f\nd out by actual te/s t ! prep>ation ma9ta9s its /ability = five or six mon?s40 ,"h are ! claims 9 detail3 8,= ! s\rce ( secret9 ,i pref]ably use t "p ( ! alim5t>y tract ( any l[] animal--su* z a hog or %eep--includ+ ! ga/ric pylorus1 ! duod5um & ! jejunum4 ,?is "p is split op5 & wa%$ ) a normal sal9e solution to clean ! mucosa or muc\s membrane ( any detritus :i* may be pres5t4 ,! mucosa ) ! epi!lial cells is !n remov$ or sep>at$ f ! muscul> wall by scrap+ ) a blunt knife or 9 any o!r suitable way4 ,! scrap+s or cutt+s1 :i* conta9 ! secret91 are !n mac]at$ or brok5 up40 8,! mac]at$ mass is plac$ 9 a suitable vessel & subject$ to ! action ( an acid solution until dige/$4 ,! "t = ! dige/ion ( ! mass w1 ( c\rse1 dep5d ^u ! /r5g? & temp]ature ( ! acid solution employ$4 ,! /rong] ! solution & ! high] ! temp]ature1 ! %ort] ! "t necess>y = complete dige/ion4 ,?is p]iod may v>y f sev]al m9utes to sev]al h\rs4 ,9 my exp]im5ts ,i f\nd t ! be/ results 7 obta9$ ) hydro*loric acid solution ( "o-t5? to five-t5?s ( "o p] c5t4 9 /r5g?1 al?\gh z high z eight-t5?s p] c5t4 might be us$4 ,! mixture is br\ght to a temp]ature ( approximately #baj ,f41 & x may ev5 = a few mom5ts exce$ t temp]ature1 b x %\ld be kept bel[ ! boil+ po9t1 = excessive heat injures or breaks d[n ! secret9 molecule & impairs or de/roys its activity4 ,al?\gh ,i pref] to use hydro*loric acid1 ,i w\ld h x und]/ood t o!r acids--bo? organic or inorganic--may be employ$1 provid$ t ! p]c5tage ( acidity is regulat$ to prev5t a *emical *ange 9 ! secret91 & fur!r provid$1 ( c\rse1 t ! acid has no injuri\s effect on ! human sy/em40 8,aft] ! mass has be5 dige/$ 9 ! heat$ solution1 ! decoction is decant$1 & aft] be+ all[$ to cool is pass$ ?r\gh a suitable filt] until ! filtrate is cle>4 ,i f\nd t by filt]+ ! decoction f f\r to six times ?r\gh a c>bon filt]1 ,i obta9$ a cle> colorless filtrate4 ,?is is a solution ( secret9 & ! acid :i* 0 us$1 & ! cle>ness ( ! solution %[s t x is practically free f albumoses1 gelat9 & o!r impurities 7su* z cell tissues1 etc47 pres5t 9 ! raw mat]ial "u treatm5t40 8,to ! solution ( pure & active secret9 prep>$ z above expla9$1 !re is add$ a suitable quantity ( blood s]um--say f "o-fif? to two p] c5t4 or any equival5t m$ium--su* z album9 solution or a peptone solution--:i* w aid & su/a9 ! activat+ p[] ( secret9 z provid$ by ! blood4 ,t is to say1 any m$ium hav+ ! same p[]1 simil> quality or *emical composition t ! blood-/ream possesses 9 comb9+ ) secret9 to /imulate ! pancreas4 ,! addition ( su* a m$ium to ! active secret9 solution increases ! pot5cy ( ! secret9 & its degree ( /ability by prev5t+ oxidation or det]ioration !re(4 ,if ?is /r5g!n+ or =tify+ m$ium1 z x may be prop]ly t]m$1 is alkal9e1 x p]=ms ! additional function ( l[]+ ! acidity ( ! secret9 filtrate4 ,x is pref]able t ! f9al product be j fa9tly acid4 ,if desir$1 ! f9al product may be made into an elixir by ! addition ( aromatics40 8,any desir$ /r5g? ( secret9 solution may be obta9$ accord+ to ! quantity ( acid solution4 ,9 my exp]im5ts ,i us$ f t5 to f\rte5 duod5a to a p9t ( acid solution40 8,! solution ( secret9 prep>$ z above describ$ is *>act]iz$ by its ability to resi/ oxidation or det]ioration = a suffici5t p]iod ( "t to r5d] ! solution available z a comm]cial article1 & is fur!rmore *>act]iz$ by fre$om f poison\s & irritable *emical sub/ances1 :]eby ! secret9 is *emically adapt$ to ! human sy/em to /imulate ! pancreas to increas$ secretion40 8,z previ\sly /at$1 ! secret9 prep>$ accord+ to my me?od may be adm9i/]$ orally to produce ! desir$ physiological action4 ,( c\rse1 if desir$1 ! secret9 might be inject$ intrav5\sly1 b ?is m or less dang]\s proc$ure is n at all necess>y1 & ,i m]ely m5tion x "h to po9t out t :5 ,i ref] to ! oral adm9i/ration ( my new secret9 prep>ation1 ,i d n mean to exclude its adm9i/ration by injection40 8,z to ! comm]cial /ability ( ! secret9 prep>$ accord+ to my me?od1 ,i may say t ,i h f\nd by actual te/s t ! prep>ation ma9ta9s its /ability = z long a p]iod z five or six mon?s4 ,:5 ,i ref] to my product z be+ 8comm]cially /able10 ,i mean t x resi/s oxidation or det]ioration = a suffici5t p]iod to r5d] ! same available z a comm]cial article4 ,?is p]iod may v>y f sev]al weeks to sev]al mon?s1 dep5d+ ^u c]ta9 comm]cial factors well und]/ood by ! manufactur]4 ,s1 r\ghly speak+1 ,i %\ld say t secret9 is comm]cially /able :5 x reta9s its activity f "o to six mon?s4 ,i d n wi% to be und]/ood1 h[ev]1 z limit+ myself to ^! exact figures40 ,t active secret9 may be extract$ f mac]at$ inte/9al mucosa by weak acids bel[ ! temp]ature ( boil+ is well kn[n4 ,9 fact1 weak acids at body temp]ature 9 contact ) ! duod5al mucosa lead to ! =mation ( secret94 ,! claims t secret9 giv5 by m\? rea*es ! blood & acts on ! pancreas has be5 made = o!r prep>ations ( secret94 ,x has also be5 %[n t ^! claims are errone\s4#abb ,?us x w\ld appe> t ! only novel elem5t 9 ,dr4 ,bev]idge's pat5t$ secret9 is ! addition ( s]um1 soluble prote9s or peptones4 ,:at reason is !re = believ+ t ?is w r5d] ! secret9 /able = mon?s1 & physiologically active :5 tak5 by m\?8 ,we d n believe ,dr4 ,bev]idge ev] inject$ 8 secret9--prote9 mixture--intrav5\sly 9 man or animals n "u ane/hesia1 o!rwise he w\ld n h /at$3 8,( c\rse1 if desir$1 ! secret9 may be inject$ intrav5\sly40 #abb ,c>lson1 ,leb5sohn & ,pe>lman1 ,! ,j\rnal1 ,jan4 #ae1 #aiaf1 p4 #agh4 ,,bev]idge',s ,,pat5t$ ,,secret9 ,,is ,,n ,,/able ,i4 ,! ,samples ( ,secret9 ,s5t ,u by ,dr4 ,bev]idge4--,physiological te/s 7 made on f\r qu>t bottles ( ! secret9 k9dly s5t u by ,dr4 ,bev]idge ,june #bf1 #aiaf4 ,accord+ to a lett] f ,dr4 ,bev]idge ( ,july #bj1 #aiaf1 ^? samples ( secret9 7 prep>$ ,june #bj1 t is1 only six days be=e receiv$ by u4 ,! mat]ial came 9 d>k color$ bottles4 ,x 0 kept 9 ! orig9al bottles & plac$ 9 ! ice box imm$iately on receipt4 ,dr4 ,bev]idge /at$ ! secret9 8%\ld rema9 active until ! mon? ( ,novemb]1 #aiaf1 at lea/40 ,te/s 7 made on ?ree out ( ! f\r bottles4 ,! f\r? bottle 0 n op5$1 z we desir$ to le>n :at *ange x might und]go 9 ! way ( prote9 precipitation & bact]ial decomposition4 ,!re is no?+ 9 ! ,bev]idge me?od ( prep>ation t insures a /]ile secret9 unless x is pass$ ?r\gh a ,b]kefeld filt]4 ,9 all our crucial exp]im5ts ! animals 7dogs7 7 kept "u light e!r ane/hesia1 a cannula ins]t$ into ! pancreatic duct1 ! blood pressure record$ f ! c>otid art]y & ! v>i\s secret9 prep>ations inject$ intrav5\sly4 ,:5 inactive secret9 prep>ations 7 enc\nt]$1 control te/s 7 always made ) active solutions ( secret9 to elim9ate possible individual peculi>ities ( ! animal4 ,?us :5 ! pancreas ( a dog reacts to ! injection ( prep>ation ,a1 b n to prep>ation ,b1 x is evid5t t abs5ce ( response to ,b is due to ?is prep>ation & n to ! animal or to ! exp]im5tal conditions4 ,illu/ration3 ,fig4 #a4--,records ( c>otid blood pressure & secretion ( pancreatic juice on intrav5\s injection ( ,bev]idge's secret9 9 dogs4 ,x1 injection ( #aj c4c4 secret92 b1 record ( fl[ ( pancreatic juice 9 drops4 ,trac+ ,a1 injection ( #aj c4c4 ( "o sample secret9 7t5 days old7 furni%$ by ,dr4 ,bev]idge4 ,trac+ ,b1 injection ( #aj c4c4 ( second sample ( secret9 7t5 days old7 furni%$ by ,dr4 ,bev]idge4 ,trac+ ,c1 injection ( #aj c4c4 ( secret9 7tw5ty h\rs old7 made by u accord+ to ! ,bev]idge me?od4 ,%[+ t ! secret9 prep>ations s5t u by ,dr4 ,bev]idge conta9$ no secret94 ,ea* ( ! ?ree samples ( secret9 s5t u by ,dr4 ,bev]idge 0 te/$ 9 ! above mann] on five dogs4 ,! fir/ te/s 7 made ,june #bg1 #bh & #bi1 respectively1 t is1 )9 n9e days ( ! prep>ation ( ^! samples ( secret94 ,none ( ! samples 0 active 7,fig4 #a71 ev5 :5 inject$ intrav5\sly 9 quantities up to #ej c4c43 #dj-ej c4c4 ( ,bev]idge's secret9 mixture may kill a dog by too great l[]+ ( ! blood pressure4 ,a good secret9 prep>ation yields a copi\s secretion ( pancreatic juice on intrav5\s injection ( a few cubic c5timet]s4 ,x is n difficult to prep>e a secret91 by ! orig9al ,bayliss or ,/>l+ me?od or by ! ,bev]idge me?od1 t reta9s "s activity = a long] p]iod ?an n9e days4 ,h5ce we _c acc\nt = ! absolute inactivity ( ^! prep>ations except on ! assumption t !y did n conta9 any secret9 to />t )2 t is1 faulty prep>ation & abs5ce ( physiologic /&>dization4 ,! sample kept intact 9 its orig9al conta9] = six mon?s became gradually cl\dy1 a l>ge mass ( amorph\s precipitate settl$ to ! bottom & ! odor %[$ bact]ial decomposition4 ,x is repreh5sible1 to say ! lea/1 to /ate conc]n+ su* a mixture3 8,( c\rse1 if desir$1 x may be inject$ intrav5\sly40 ,! fact t ,bev]idge's secret9 may be r5d]$ cle> by filt]+ ?r\gh c>bon is n suffici5t evid5ce t x is 8pure secret910 free f bact]ia & o!r injuri\s sub/ances4 ,,ii4 ,bev]idge ,secret9 ,mixture ,is ,rapidly ,r5d]$ ,inactive by ,human ,ga/ric ,juice4--,we prep>$ active secret9 solutions by ! ,bev]idge me?od1 us+ #j4b p] c5t4 s]um z ! prote9 8/abiliz]0 7874 ,! addition ( ! s]um does n appe> to affect ! activity ( ! fre% secret9 prep>ation4 ,if ,bev]idge's secret9 is able to act on ! pancreas :5 giv5 by m\?1 x is obvi\s t x mu/ run ! gamut ( ga/ric dige/ion1 except 9 cases ( complete a*lorhydria4 ,x has be5 repeat$ly demon/rat$ t all o!r secret9 prep>ations are rapidly de/roy$ by peps9-hydro*loric acid dige/ion4 ,is ,bev]idge's secret9 an exception8 ,:at is !re 9 a little s]um1 native album91 or peptones to protect secret9 aga9/ ga/ric dige/ion8 ,! pure human ga/ric juice us$ 9 ^! te/s 0 secur$ f ! fi/ula case 7,mr4 ,f4 ,v47 t has be5 "u obs]vation 9 our laboratory = ye>s4#abc #abc ,c>lson3 ,! ,control ( ,hung] 9 ,heal? & ,disease1 ,*icago1 #aiaf4 ,,bev]idge',s ,,secret9 ,,& ,,bayliss-,,/>l+ ,,secret9 ,,prep>$ ,sept4 #bi1 #aiaf ,response ( ,pancreas 7,no4 ( ,drops ( ,secret97 ,date ( ,te/ ,quantity ( ,secret9 ,bayliss-,/>l+ ,bev]idge ,inject$1 ,c4c4 ,secret9 ,secret9 ,sept4 #bi4 #aj #ge #gh ,oct4 #b4 #aj #fa #fa ,oct4 #f4 #aj #bh #ag ,oct4 #ac4 #aj #be #ca ,oct4 #bg4 #aj #e #f ,nov4 #c4 #aj #g #f ,nov4 #ag4 #aj #d #e ,nov4 #cj4 #aj #c #d ,dec4 #d4 #aj #b #b ,dec4 #bj4 #aj #j #j ---------------------------------------- ------------------------ ,two cubic c5timet]s ( fre% ga/ric juice add$ to #h-aj c4c4 ,bev]idge secret91 ! mixture be+ kept at body temp]ature 7#ch ,c471 r5d]s ! secret9 completely inactive 9 f #e to #h m9utes 7,fig4 #b74 ,!re is no exception to ?is rule1 z we h repeat$ ! te/ on _m diff]5t secret9 prep>ations & us+ diff]5t samples ( human ga/ric juice4 ,! secret9 ( ,bev]idge is j z vuln]able z ! secret9 ( ,bayliss & ,/>l+ to peps9-hydro*loric acid dige/ion4 ,on :at k9d ( te/s does ,bev]idge base 8 claim t 8 secret9 mixture acts on ! pancreas :5 giv5 by m\?8 ,,iii4 ,! ,relative ,rate ( ,det]ioration ( ! ,secret9 ,solutions ,prep>$ ,accord+ to ,bayliss & ,/>l+ & ,accord+ to ,bev]idge4--,six diff]5t prep>ations ( ! two k9ds ( secret9 7 made1 kept 9 d>k /opp]$ bottles 9 ! ice box1 & te/$ by intrav5\s injection 9 dogs "u e!r ane/hesia f "t to "t until all influ5ce on ! pancreas _h be5 lo/4 ,"o typical s]ies ( ^! te/s is giv5 by ! way ( illu/ration4 7,see ,table on page #abf47 ,illu/ration3 ,fig4 #b4--,records ( c>otid blood pressure & fl[ ( pancreatic juice on intrav5\s injection ( secret9 prep>$ by u accord+ to ! ,bev]idge me?od4 ,x1 injection ( #aj c4c4 ( ! secret92 b1 record ( fl[ ( pancreatic juice 9 drops4 ,trac+ ,a1 ! #aj c4c4 ( ,bev]idge's secret9 inject$ _h be5 dige/$ = five m9utes ) #c c4c4 ( human ga/ric juice4 ,trac+ ,b1 injection ( #aj c4c4 ( ! same secret9 prep>ation n subject$ to ga/ric dige/ion4 ,%[+ rapid & complete de/ruction ( ,bev]idge's secret9 by human ga/ric juice4 ,x w be se5 t ! rate ( det]ioration 7oxidation or decomposition7 ( ! secret9 is practically ! same :e!r prep>$ accord+ to ,bayliss & ,/>l+ or accord+ to ,bev]idge 7,figure #c74 ,9 bo? prep>ations ! rate ( det]ioration is mo/ rapid ! fir/ few days aft] prep>ation4 ,x is sc>cely necess>y to po9t out t secret9 prep>ations n kept con/antly at l[ temp]ature & 9 ! d>k1 z 9 ! above exp]im5ts1 w det]iorate m rapidly4 ,illu/ration3 ,fig4 #c4--,records ( c>otid blood pressure & fl[ ( pancreatic juice on intrav5\s injection ( secret9 prep>ations4 ,x1 injection ( #aj c4c4 secret92 b1 record ( fl[ ( pancreatic juice 9 drops4 ,trac+ ,a1 secret9 prep>$ accord+ to ! ,bev]idge me?od ,septemb] #cj4 ,i1 injection ( #aj c4c4 ,octob] #b4 ,,ii1 injection ( #aj c4c4 ,novemb] #cj4 ,trac+ ,b1 secret9 prep>$ by ! ,bayliss-,/>l+ me?od ,septemb] #cj4 ,,iii1 injection ( #aj c4c4 ,octob] #b2 ,,iv1 injection ( #aj c4c4 ,novemb] #cj4 ,%[+ no great] /ability ( ,bev]idge's secretion ov] t ( ,bayliss & ,/>l+4 ,:y c we hope t ! addition ( s]um or any solution ( prote9 w r5d] secret9 m /able8 ,9 ! intact man or animal "u normal conditions ( dige/ion1 secret9 rea*es ! pancreas by way ( ! blood1 t is1 x is 9 solution 9 blood4 ,does t fact r5d] ! secret9 /able8 ,by no means4 ,! read] is famili> ) ! fact t ! response ( ! pancreas to a s+le intrav5\s adm9i/ration ( secret9 is v transitory 7#e-ae m9474 ,! cessation ( activity is due1 n to fatigue ( ! pancreas1 z a second injection ( secret9 gives a prompt response ( pancreatic secretion1 b to ! disappe>ance ( active secret9 f ! blood4 ,9 fact1 secret9 left 9 ! te/ tube or 9 ! bottle rema9s active ov] a mu* long] p]iod ( "t ?an :5 introduc$ into ! blood /ream4 ,,iv4 ,bev]idge's ,secret9 ,giv5 by ,m\? to ! ,intact ,animal ,has ,no ,specific ,action on ! ,pancreas4--,active secret9 prep>$ accord+ to ! me?od ( ,bev]idge 0 f$ on an empty /oma* to a small dog 7#e kilo7 ) p]man5t fi/ula ( "o ( ! pancreatic ducts4 ,on control days we gave ! dog 7a7 equal quantities ( n_/#aj ,h,cl1 & 7b7 bread & milk4 ,! ,bev]idge secret9 0 prep>$ ) #j4c p] c5t4 ,h,cl & ! addition ( #j4b p] c5t4 s]um4 ,! results may be /at$ by ! foll[+ summ>y3 ,,giv+ ,,bev]idge',s ,,secret9 ,,by ,,m\? ,secret9 ( ! ,numb] ( ,pancreas = ,?ree ,mat]ial ,f$ ,te/s ,h\rs ,foll[+ ! ,fe$+ #aej c4c4 ,bev]idge ,secret9 #f #aj4b c4c4 #aej c4c4 n_/#aj ,h,cl #e #bb4g c4c4 ,bread soak$ 9 milk #d #f4f c4c4 ---------------------------------------- ------------------------ ,! ,control exp]im5ts ) pure hydro*loric acid %[ t ! secretion ( pancreatic juice foll[+ ! introduction ( ,bev]idge's secret9 into ! /oma* is due to ! acid factor & ! prote9 cont5t4 ,,conclusions ,! pat5t$ secret9 ( ,bev]idge is r5d]$ inactive by ga/ric juice1 is )\t effect :5 giv5 by m\?1 & exhibits no great] /ability or keep+ qualities ?an ! secret9 prep>$ accord+ to ,bayliss & ,/>l+4 ,x has no m]it z a !rapeutic ag5t4 ,x %\ld "u no conditions be adm9i/]$ intrav5\sly 9 man1 z x conta9s delet]i\s prote9 split products & liv+ bact]ia4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #ab1 #aiah47 ,,ne$ ,,= ,,pat5t ,,law ,,revision ,report ( ! ,committee on ,pat5t-,law ,revision ( ! ,c\ncil on ,ph>macy & ,*emi/ry ( ! ,am]ican ,m$ical ,association ,at ! pres5t critical "t :5 ! effici5cy ( ?is nation mu/ be rais$ to ! highe/ po9t1 x is ess5tial t ! ,unit$ ,/ates gov]nm5t %\ld lead 9 ! ef=ts t5d+ to su* increas$ effici5cy4 ,to br+ ?is ab\t ! gov]nm5t mu/ protect & /imulate sci5ce1 art & indu/ry & at ! same "t curb or prev5t wa/e ( ! c\ntry's res\rces4 ,9 ?is field ! ,unit$ ,/ates ,pat5t ,(fice has unlimit$ p[] = good & evil--good1 9 ! issuance ( pat5t grants = novel devices & sub/ances :i* g to increase national effici5cy2 evil1 9 ! grant+ ( pat5t protection :]e su* protection is n 9 ! int]e/ ( national effici5cy1 cons]vation ( en]gy & mat]ial res\rces4 ,= ye>s ! ,am]ican ,m$ical ,association1 9 common ) ! national ph>maceutical bodies1 has be5 urg+ am5dm5t ( ! law :i* gov]ns ! issuance ( pat5ts on m$ic9al prep>ations & m p>ticul>ly revision ( ! proc$ure "u :i* su* pat5ts are issu$4 ,at ! ,*icago 7#aijh7 meet+ ( ! ,am]ican ,m$ical ,association a special committee ( five 0 appo9t$ by ! ,h\se ( ,delegates to /udy ! que/ions involv$1 & to coop]ate ) ! ,association's committee on m$ical legislation 9 prep>+ & secur+ ! enactm5t ( a bill :i* w\ld correct ! abuses connect$ ) ! en=cem5t ( our pat5t laws 7,! ,j\rnal ,a4 ,m4 ,a41 ,june #ac1 #aijh1 p4 #bjjc74 ,?is committee pres5t$ a compreh5sive report at ! ,atlantic ,city 7#aiji7 meet+ ( ! ,am]ican ,m$ical ,association 7,! ,j\rnal ,a4 ,m4 ,a41 ,june #ai1 #aiji1 p4 #bjfc74 ,a fur!r report 0 pres5t$ at ! ,/4 ,l\is 7#aiaj7 meet+ ( ! ,am]ican ,m$ical ,association 7,! ,j\rnal ,a4 ,m4 ,a41 ,june #ah1 p4 #bjgi74 ,9 #aiaa 7,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #be1 #aiaa1 p4 #aghj7 ! ,c\ncil on ,ph>macy & ,*emi/ry ( ! ,am]ican ,m$ical ,association issu$ a report :i* set =? ! inadequacy ( our pat5t laws z !y are adm9i/]$ 9 relation to m$ical products p>ticul>ly4 ,,aga9/ ,,public ,,int]e/ ,s9ce t "t ! ,c\ncil has cont9u$ its /udy ( ! ,u4 ,s4 ,pat5t law z x applies to m$ic9e & has become conv9c$ t 9 _m in/ances ! pat5t law or its en=cem5t is contr>y to ! be/ int]e/ ( ! public1 bo? z conc]ns heal? & prosp]ity4 ,! ,c\ncil feels x a duty at ?is "t to prote/ aga9/ ! provisions ( our pat5t law1 or ! me?ods ( its en=cem5t1 :i* p]mit ! grant+ ( pat5ts )\t ?or\gh & sci5tific inve/igation ( ! claims advanc$ 9 su* lett]s pat5t4 ,z "o means ( improv+ conditions ! ,c\ncil urges t ! ,u4 ,s4 ,public ,heal? ,s]vice1 ! ,bureau ( ,*emi/ry1 ,u4 ,s4 ,dep>tm5t ( ,agriculture & o!r sci5tific dep>tm5ts ( ! ,unit$ ,/ates gov]nm5t conv]sant ) m$ic9es & relat$ subjects be consult$ be=e ! issuance ( pat5ts on m$ic9al prep>ations4 ,9 support ( ! ,c\ncil's cont5tion t ! pat5t law proc$ure requires revision1 ! foll[+ is (f]$3 ,9 #aiab a ,u4 ,s4 ,pat5t 7,no4 #a1jca1iga7 0 grant$ on a cresol d]ivative1 metacresyl acetate1 a product describ$ 9 *emical lit]ature 9 #aijc4 ,:5 ! ,c\ncil inquir$ z to ! gr\nds = ! issuance ( a pat5t = a sub/ance kn[n to sci5ce1 ! ,pat5t ,(fice repli$ t x 0 n famili> ) ! publication 9 :i* metacresyl acetate _h be5 describ$4 ,x seems evid5t t ?is pat5t w\ld n h be5 issu$ _h ! application fir/ be5 submitt$ to a gov]nm5t dep>tm5t famili> ) *emical lit]ature4 ,an illu/ration ( ! grant+ ( a pat5t on ! use ( well-kn[n *emical bodies :i* pres5t no discov]y or orig9ality1 is ! pat5t issu$ = ! use ( p]oxids1 p]borates & p]c>bonates z +r$i5ts ( too? p[d]s 7,u4 ,s4 ,pat5ts ,nos4 #gfj1cig & #hjb1jii74 ,reg>d+ ^! pat5ts ,! ,j\rnal ( ! ,am]ican ,m$ical ,association 7,sept4 #bj1 #aiac1 p4 #igh7 comm5t$3 8,! pat5ts held by ,mc,kesson & ,robb9s give ?is firm ! exclusive "r ( manufactur+ too? p[d]s conta9+ p]oxids1 p]borates & p]c>bonates4 ,x is ano!r illu/ration ( ! unfair monopolies t may be secur$ "u our pres5t pat5t laws40 ,,grant+ ,a ,,pat5t ,,to ,a ,,no/rum ,aga9 9 #aiac ,u4 ,s4 ,pat5t ,no4 #a1jha1jfi 0 grant$ to a citiz5 ( ,switz]l& 7a c\ntry :i* does n grant pat5ts on m$ic9al prep>ations7 = a 8composition :i* is int5d$ to be us$ int]nally & :i* conf]s to ! organisms immunity aga9/ ! foll[+ microbial infecti\s illnesses3 diph!ria1 pneumonia1 typhus1 sc>let fev]1 influ5za1 septic infections1 c]ebral-sp9al m5+itis1 syphilis1 pe/1 *ol]a & tub]culosis2 x is also effective 9 ano!r k9d ( disease1 viz41 goit]40 7,italics n 9 orig9al74 ,! pat5t specification /ates t 8,! pr9cipal ( ^! sub/ances is creat99 44410 b (f]s no evid5ce :atev] t ?is well-kn[n *emical body has ! ext5sive & miracul\s p[]s claim$ = x4 ,9 publi%+ a notice ( ?is pat5t ,! ,j\rnal ( ! ,am]ican ,m$ical ,association 7,jan4 #c1 #aiad1 p4 #ed7 expla9$3 8,x appe>s t ! inv5tor is dead1 & t 8 e/ate took out ! pat5t4 ,s9ce ?is great b5efactor %\ld h be51 by ! use ( 8 prep>ation1 immune to practically all diseases1 he mu/ h di$ ( s5ility1 al?\gh ?is seems h>dly to h be5 ! case40 & held3 8,assur$ly grant+ pat5ts on su* claims ought to be suffici5t to %[ ! ne$ ( a *ange 9 ! me?ods ( grant+ pat5ts--at lea/ ( ! me?ods gov]n+ ! issuance ( pat5ts = m$ic9al products40 ,we submit1 t _h ! dep>tm5t ( ! gov]nm5t entru/$ ) ! en=cem5t ( ! f$]al ,food & ,drugs ,act be5 consult$ z to ! claims ( ?is pat5t1 x w\ld probably h advis$ t1 if ! absurd & palpably fraudul5t claims set =? 9 ?is application = a pat5t 7 made on ! label ( a prep>ation ( creat99 (f]$ = sale 9 int]/ate comm]ce or 9 ! ,di/rict ( ,columbia1 ! v5dor w\ld be prosecut$4 ,9 #aiad !re 0 issu$ ,u4 ,s4 ,pat5t ,no4 #a1jhf1cci4 ,"h ! 8inv5tor0 decl>$3 8,x is ! object ( my inv5tion to de/roy p>asitic micro-organisms1 p>ticul>ly on liv+ tissue )\t injur+ ! latt]1 by progressively evolv+ sodium hydroxid contigu\s to said tissue1 f & 9 a moi/ mixture ( calcium hydroxid1 sodium c>bonate1 alum9um sulfate & boric acid44440 ,9 a ^w1 ?is pat5t app>5tly 0 grant$ = ! production ( sodium hydroxid by a *emical reaction :i* _h be5 9 use = sev]al c5turies4 ,because ! pat5tee _h twi/$ ! grant+ ( ?is pat5t into a quasi-endorsem5t ( 8 no/rum1 ! ,c\ncil's consid]ation ( ?is prep>ation 0 s5t ! ,pat5t ,(fice z a prote/ aga9/ ! pres5t law :i* au?orizes ! grant+ ( pat5ts on unprov$ & improbable m$ical claims4 ,at t "t ! ,c\ncil 0 in=m$ by ! ,pat5t ,(fice t re=ms 9 ! issuance ( pat5ts = m$ic9al sub/ances _h be5 in/itut$1 & t 8! tr\ble w n be s pron\nc$ 9 ! future z x has be5 9 ! pa/40 ,,flavor+ ,,epsom ,,salt ,a 8,,discov]y0 ,!re 0 issu$ e>ly 9 #aiag ,u4 ,s4 ,pat5t ,no4 #a1bab1hhh = a me?od ( flavor+ ,epsom salt--yet ?is 8discov]y0 is a proc$ure :i* has be5 practic$ ev] s9ce ! ca?>tic action ( ?is bitt] salt has be5 kn[n4 ,n only does ! pat5t describe a process long kn[n to physicians & ph>maci/s1 b x sets =? claims t ! flavor$ ca?>tic salt produc$ by ! process cures flatul5cy1 indige/ion1 sick & s\r /oma*1 colic & de/roys worms4 ,9 comm5t+ on ?is pat5t ,! ,j\rnal ( ! ,am]ican ,m$ical ,association 7,june #bc1 #aiag1 p4 #aiad7 0 con/ra9$ to rem>k3 8,! spl5did conception ( ! fram]s ( our con/itution 9 provid+ a plan = promot+ progress 9 sci5ce & useful arts by grant+ to inv5tors = a limit$ "t ! exclusive use ( _! inv5tions1 9 ex*ange = ! publication ( full k !re(1 is be+ debas$4 ,no bran* ( our gov]nm5t is ( great] importance to ! progress ( ! c\ntry ?an ! pat5t (fice1 provid$ t (fice is intellig5tly adm9i/]$4 ,:5 ! pat5t (fice is us$1 h[ev]1 = an ext5sion ( ! no/rum bus9ess1 f\nd$ on ! abuse ( pat5t & trade-m>k laws1 x becomes a m5ace to ! public heal?4 ,! objects ( ! pat5t law are be+ defeat$ by ! practices ( ! pat5t (fice40 ,/ill fur!r1 att5tion is call$ to ,u4 ,s4 ,pat5t ,no4 #a1bbf1cid = a process ( mak+ hexame?yl5am9 tetraiodid & on ! product s produc$4 ,?is pat5t 0 issu$ aft] ! ,c\ncil _h notifi$ ! ,pat5t ,(fice t hexame?yl5am9 tetraiodid _h be5 discov]$ 9 #ahhh & t a process id5tical 9 pr9ciple ) t = :i* pat5t application appe>$ to h be5 made 0 publi%$ 9 #aiaf4 ,on ! basis ( claims = :i* no evid5ce is produc$ ?is pat5t is issu$ = a well-kn[n sub/ance on ! gr\nd t z previ\sly produc$ x conta9$ a little free iod9 or t ! kn[n processes 7 less economical4 ,?is pat5t appe>s to be an illu/ration ( our pat5t proc$ure :i* oblig$ ,am]ican us]s ( acetylsalicylic acid to pay an exorbitant price because ?is c\ntry grant$ a pat5t :i* gave to ! pat5tee1 a =eign]1 ! exclusive "r to ! manufacture ( ! sub/ance1 :]eas no su* pat5t 0 issu$ 9 ! pat5tee's own c\ntry nor1 s f> z we c le>n1 9 any o!r c\ntry4 ,x =cibly illu/rates ! ne$ = a revision ei!r ( our pat5t laws or ( _! me?ods ( en=cem5t or bo?4 ,,! ,,bev]idge ,,pat5t ,9 fur!r ju/ification ( ! ,c\ncil's prote/ aga9/ ! provisions ( our pres5t law1 or ! me?ods ( its en=cem5t1 :i* p]mit ! grant+ ( pat5ts )\t ?or\gh & sci5tific inve/igation ( ! claims advanc$ 9 su* lett]s pat5t1 ! ,c\ncil calls att5tion to ! report1 appe>+ above1 ( an inve/igation made by ,a4 ,j4 ,c>lson1 ,a4 ,e4 ,kant] & ,i4 ,tump[ski1 8,! ,"q ( ! ,/ability ( ,secret910 :i* relates to ,u4 ,s4 ,pat5t ,no4 #a1aha1dbd1 issu$ to ,james ,wallace ,bev]idge4 ,:]eas ! regulations gov]n+ ! issuance ( pat5ts dem& t ! processes %all be describ$ 9 su* detail t "o v]s$ 9 ! sci5ces c confirm ! claims made by ! pat5tee1 no pret5se :atev] ( fulfill+ ?is requirem5t is made 9 ! pat5t specifications ( ?is pat5t4 ,! sub/ance ( ! fir/ ?ree p>agraphs ( ?is pat5t has long be5 g5]al k4 ,ne>ly e sophomore m$ical /ud5t has himself p]=m$1 or se5 p]=m$ su* 8exp]im5ts0 z are !re9 describ$4 ,! claims ( novelty evid5tly are conf9$ to ! ass]tion t ! prep>ation is able to 8resi/ oxidation or det]ioration02 t x is free f 8poison\s & irritable *emical sub/ances02 t x 8may be adm9i/]$ orally to produce ! desir$ physiological action40 etc41 etc4 ,n ! slighte/ h9t is giv5 z to h[ any p]son c sub/antiate ^! claims4 ,z a matt] ( fact1 ! inve/igation ( ,pr(essor ,c>lson & 8 co-work]s has %[n t a prep>ation hav+ ! prop]ties claim$ _c be made by ! process describ$ 9 ?is pat5t4 ,any "o famili> ) ! subject c\ld h demon/rat$ readily t ! applicant 0 )hold+ in=mation conc]n+ ess5tial features ( 8 process1 assum+ t he _h any in=mation on ! subject 7:i* he probably did n h7 & w\ld h advis$ aga9/ ! issuance ( ! ,bev]idge pat5t4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #ab1 #aiah47 ,,surgod9e ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! foll[+ report submitt$ by a ref]ee 0 adopt$ by ! ,c\ncil & au?oriz$ = publication4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,surgod9e 7,%>p & ,dohme1 ,baltimore1 ,md471 accord+ to an adv]tis+ pamphlet1 is a solution ( #b-a_/d p] c5t4 ( iod9 9 alcohol1 conta9+ no alkal9e iodid1 b miscible ) wat] 9 all proportions4 ,! ,a4 ,m4 ,a4 ,*emical ,laboratory reports t ,surgod9e is an alcoholic liquid 7conta9+ #ia4h p] c5t4 alcohol by volume7 conta9+ free iod91 comb9$ iod9 & free acid1 probably hydrog5 iodid 7hydriodic acid74 ,quantitative e/imations gave #b4ea gm4 free iod9 p] #ajj c4c4 & #a4gh gm4 comb9$ iod9 7! great] "p app>5tly 0 pres5t z hydrog5 iodid74 ,x is !re=e simil> to sev]al o!r iod9 prep>ations already consid]$ by ! ,c\ncil4 ,l ^!1 x is ess5tially simil> to ! (ficial t9cture ( iod91 except t x is consid]ably weak]1 & in/ead ( potassium iodid x presumably conta9s hydrog5 iodid & probably e?yl iodid to r5d] ! iod9 wat]-soluble4 ,its composition1 h[ev]1 is secret4 ,!re w\ld be no objection to ! use ( e?yl iodid or hydrog5 iodid1 except p]haps ! acidity ( ! latt]1 z a solv5t ag5t r ?an ( potassium iodid4 ,b nei!r is !re any important advantage1 & ^! prep>ations w\ld h to be consid]$ z uness5tial modifications ( (ficial prep>ations1 & !re=e ineligible = ,new & ,non(ficial ,rem$ies4 ,! attempt to make ^! modifications comm]cially pr(itable1 h[ev]1 seems inevitably to lead to exagg]ations & mis/atem5ts4 ,9 an adv]tis+ pamphlet ! foll[+ claims = ,surgod9e are unsupport$ by any evid5ce3 8,b f ! surgical viewpo9t ! addition ( ?is potassium salt is mo/ objectionable because :5 su* solutions z ! (ficial t9cture are us$ locally 9 ! antiseptic treatm5t ( op5 & (t5 infect$ w\nds ! ,potassium ,iodide acts z an irritant to ! w\nd & !re=e produces a localiz$ irritation :i* is n only objectionable f ! surgical /&po9t b also mat]ially less5s ! antiseptic p[] ( ! ,iod9e itself40 8,x has be5 demon/rat$ repeat$ly t ,iod9e )\t ! admixture ( any alkal9e iodide is mu* m effici5t z a surgical antiseptic ?an any iod9e solution t conta9s su* an addition40 8,iod9e does n produce #8iodism' z quickly z ! alkal9e iodides d because x is elim9at$ m quickly & m p]fectly ?an ! alkal9e iodides40 ,! next /atem5t intimates t iod9 tak5 by m\? ent]s ! inte/9al tract un*ang$ & is !re free to comb9e ) v>i\s gases3 8,iod9e 9 ! pres5ce ( phosphorat$ or sulphurat$ gases 9 ! ga/ro-inte/9al tract unites ) _! hydrog5 & ?us breaks up ^! noxi\s comp\nds40 ,?is is c]ta9ly untrue at lea/ = ord9>y doses4 ,x is recomm5d$ t ,surgod9e be held inadmissible to ,new & ,non(ficial ,rem$ies because its composition is secret 7,rule #a72 because ! !rapeutic claims made = x are exagg]at$ & unw>rant$ 7,rule #f72 & because x is an uness5tial modification ( ! (ficial t9cture ( iod9 7,rule #aj74 ,editorial ,comm5t4--,surgod9e is a good illu/ration ( ! economic wa/e insep>able f mo/ propriet>y m$ic9es4 ,a hospital ph>maci/ writes t :]eas 8 hospital obta9s t9cture ( iod9 at less ?an #hb c5ts a p9t1 ,surgod9e co/s #b4ac a p9t4 ,?is means t :ile ! free-iod9 /r5g? ( ,surgod9e is only ab\t "o-?ird t ( ! (ficial t9cture1 its price is betwe5 two & ?ree times z high4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #bf1 #aiah7 ,,m$eol ,,suppositories ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! foll[+ report on ,m$eol ,suppositories has be5 adopt$ by ! ,c\ncil1 & its publication au?oriz$4 ,w4 ,a4 ,puckn]1 ,secret>y4 8,m$eol ,suppositories0 7,m$eol ,company1 ,inc41 ,new ,york7 appe> to be an imitation ( 8,anusol ,suppositories0 :i*1 9 #aijg1 7 f\nd to be inadmissible to ,new & ,non(ficial ,rem$ies4 ,a comp>ison ( ! composition & ( ! claims made = ! two prep>ations w be ( int]e/ 9 ! pres5t consid]ation ( ,m$eol ,suppositories3 ,,anusol ,,suppositories 7#aiji7 ,,m$eol ,,suppositories 7#aiag7 ,anusoli #g4e ,m$eol #j4be ,z9c oxid #f4j ,z9c oxid #j4e ,balsam ,p]u #a4e ,acid4 tannic #j4ae ,ol4 !obrom4 #ai4j ,bals4 ,p]u #j4af ,ungt4 c]at4 #b4e ,cocoa butt] & wax q4 s4 = #ab suppositories4 = #a suppository4 8,anusol0 0 =m]ly said to be bismu? iodoresorc9sulphonate4 ,! ,a4 ,m4 ,a4 ,*emical ,laboratory publi%$ a report 9 #aiji %[+ t ! suppositories conta9$ only #a p] c5t4 ( ! iod9 decl>$ 9 ! 8=mula10 & 7 greatly defici5t 9 bismu? & sulphur4 ,aft] ! publication ( ! report ! ,am]ican ag5ts = ! product disclaim$ t 8,anusol0 0 a def9ite *emical comp\nd4 ,today ,anusol ,suppositories are said to conta9 un/at$ am\nts ( ! indef9ite 8bismu? oxyiodid & resorc9sulphonate40 8,m$eol0 is said to be 8resorc9at$ iodo bismu?10 b no in=mation is v\*saf$ z to ! "* or composition ( ! +r$i5t4 ,! !rapeutic claims made = ! two prep>ations are simil>1 z ! foll[+1 tak5 f circul>s1 %[3 ,,anusol ,,suppositories ,an innocu\s1 non-irritant rem$y = anal1 rectal & vag9al inflammatory affections1 especially = ,,hemorrhoids6 ,! local m$ic9al treatm5t ( hemorrhoidal & o!r inflammatory ano-rectal conditions has always be5 unsatisfactory4 ,! usual m$ia _c be appli$ 9 effective conc5tration )\t produc+ int5se inflammatory reactions2 !y are ei!r ineffective or intol]able4444 ,anusol suppositories are absolutely free f n>cotic1 cau/ic or o!r injuri\s +r$i5ts & may unhesitat+ly be us$ by bo? sexes1 at any age & "u all conditions4 ,,m$eol ,,suppositories ,an innocu\s1 ,non-irritant1 ,effici5t ,antiphlogi/ic = use 9 inflammatory diseases ( ! rectum1 anus & vag9a especially 9 ,,hemorrhoids4 ,hi!rto mo/ ( ! local rem$ies us$ 9 ^! conditions h ei!r be5 too irritat+ to be employ$ 9 suffici5t conc5tration to be effici5t or !y h lack$ effici5cy p] se4444 ,m$eol suppositories d n conta9 any n>cotic or any cau/ic or o!r con/itu5t hav+ viol5t action2 _! bl&ness p]mits ( _! use 9 ei!r sex & at all ages4 ,! claims made = ^! prep>ations--z = in/ance 8t surgical treatm5t 444 %\ld r>ely be und]tak5 until ,m$eol ,suppositories h be5 giv5 a ?or\gh trial0--are mislead+ 9 t !y create ! inf]5ce t ! limitations 9 ! palliative treatm5t ( piles h be5 ov]come4 ,x is altoge!r untrue t ^! mixtures c be expect$ to 8relieve ! mo/ ob/9ate cases10 z /at$ 9 a ,m$eol circul>4 ,?is1 f an ,anusol circul>1 is equally mislead+3 8,if dietetic & o!r requirem5ts are compli$ )1 ev5 ! mo/ ob/9ate *ronic cases w frequ5tly readily yield to treatm5t ) ,anusol ,suppositories40 ,! ,c\ncil decl>$ ,m$eol ,suppositories inadmissible to ,new & ,non(ficial ,rem$ies because _! composition is secret 7,rules #a & #b72 because unw>rant$ !rapeutic claims are made = ^! 7,rule #f72 because ! "n is objectionable 7,rule #h71 & because ! comb9ation is unsci5tific 7,rule #aj74 ,9 ^? cases ( hemorrhoids 9 :i* palliative measures may be expect$ to enable ! pati5t to avoid surgical int]f]5ce & af=d relief f attacks1 ! object %\ld be to secure cleanl9ess1 to avoid irritation1 :e!r x be by friction or irritat+ fecal matt]1 to r$uce inflammation by a/r+5ts &1 :5 necess>y1 to relieve pa9 by analgesics4 ,if an antiseptic du/+ p[d] is desir$1 boracic acid 9 impalpable p[d] ) talc may be employ$2 if an a/r+5t1 f9ely p[d]$ oxid ( z9c may be add$2 if a local analgesic is necess>y1 a little extract ( belladonna may be incorporat$ ) petrolatum or o!r o9tm5t base4 ,! ma9 reliance1 9 any ev5t1 %\ld be to effect normal b[el movem5ts by regulat+ ! diet r ?an by ! use ( purgatives2 ! use ( w>m wat] to insure cleanl9ess2 ! avoidance ( irritation1 especially t caus$ by friction & secretions2 a mild a/r+5t to r$uce inflammation4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,m>* #i1 #aiah7 ,,guaiod9e ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! foll[+ report on ,guaiod9e1 m>ket$ by ! ,intrav5\s ,products ,company1 ,d5v]1 has be5 adopt$ by ! ,c\ncil & its publication au?oriz$4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,a ref]ee ( ! ,committee on ,ph>macology1 9 submitt+ to ! ,c\ncil a report f ! ,a4 ,m4 ,a4 ,*emical ,laboratory on ,guaiod9e1 advises t ! ,laboratory's exam9ation %[s t in/ead ( conta9+ free 8colloidal0 iod9 z claim$1 ! prep>ation is ess5tially an iodat$ fatty oil1 conta9+ only comb9$ iod94 ,equally mislead+1 9 view ( ! ,laboratory's f9d+s1 are ! impli$ claims t ! antiseptic action ( ,guaiod9e corresponds to t ( free iod94 ,guaiod9e is adv]tis$ ma9ly = ! treatm5t ( gonorrhea4 ,:ile x may be true t ! guaiacol conta9$ 9 ,guaiod9e has "s b5eficial effect1 especially :5 prec$$ by potassium p]manganate irrigation z advis$1 ! adv]tis$ claim t 8,guaiod9e acts z a specific = gonorrhea 9 a majority ( cases0 is utt]ly false4 ,! 8case records0 (f]$ to e/abli% ! !rapeutic value ( ,guaiod9e are 9 !mselves suffici5t to condemn ! 8evid5ce40 ,! foll[+ are fair samples3 8,! second boy came a day or s lat] ) a slight dis*>ge ) ! *>act]i/ic burn+ & it*+1 & ) symptoms ( a beg9n+ gonorrhea1 & judg+ f ! s\rce ( ! infection1 x 0 believ$ to be s4 ,two injections ( ,guaiod9e 7 giv5 :5 ! dis*>ge ceas$40 8,i h sev]al cases t 7 completely cur$ 9 a v %ort "t4 ,i note ?is1 t ! fir/ dose causes a cessation ( ! dis*>ge & ! second seems to increase ! fl[1 b ! color is *ang$4 ,i give ?ree doses1 & !n use a mild wa%1 & 9 t5 days !y are well4 ,i am v pleas$ ) ?is prep>ation & v truly believe t x is ! be/ !re is to date = ! positive cure ( gonorrhea40 ,,report ,,( ,,! ,,*emical ,,laboratory ,guaiod9e is manufactur$ by ! ,intrav5\s ,products ,company1 ,d5v]1 ,colorado4 ,! 8lit]ature0 :i* accompanies ! product describes ,guaiod9e z3 8444 an electro-*emically prep>$ iod91 susp5d$ 9 oil1 conta9+ iod91 ! same /r5g? z ! ,u4 ,s4 ,p4 t9cture ( iod91 or #g p] c5t41 toge!r ) a !rapeutic dose ( guaiacol40 ,! ,intrav5\s ,products ,company claims t ,guaiod9e is made by an 8electro-*emical process ( prep>+ colloidal iod9e10 discov]$ by "o ,e4 ,b4 ,page1 & t by ?is process ! t5d5cy ( iod9 to produce iodism has be5 8ov]come40 ,x is said to be 8pre-em95tly an antiseptic & g]micide40 ,guaiod9e is a d>k br[n1 oily liquid ) a specific gravity ( #j4ihde at #ae4f ,c4 & an odor sugge/ive ( guaiacol4 ,its solubilities 7 ^? ( a fat4 ,free iod9 0 abs5t 9 ! rec5tly pur*as$ specim5 7traces 7 pres5t 9 an old] "o74 ,/eam di/illation indicat$ t ! product consi/$ ( volatile & nonvolatile con/itu5ts4 ,! volatile matt] 0 conclud$ to consi/1 9 ! ma91 ( guaiacol or "s guaiacol-l body1 & ! nonvolatile matt] to be an iodiz$ fatty oil4 ,quantitative det]m9ations indicat$ t ,guaiod9e conta9$ ab\t #g4be p] c5t4 ( iod9 9 comb9ation1 & t x is compos$ approximately ( #c p] c5t4 volatile matt] & #ig p] c5t4 nonvolatile matt]4 ,h5ce ,guaiod9e appe>s to be an iodiz$ fatty oil to :i* a small am\nt ( guaiacol or "s guaiacol-l sub/ance has be5 add$4 ,,! ,,c\ncil',s ,,action ,on ! recomm5dation ( ! ref]ee1 ! ,c\ncil vot$ t ,guaiod9e be decl>$ inadmissible to ,new & ,non(ficial ,rem$ies because ( false /atem5ts z to composition & action4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,april #f1 #aiah47 ,,sev]al 8,,mix$0 ,,vacc9es ,,n ,,admitt$ ,,to ,n4 ,n4 ,r4 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! 8mix$0 vacc9es :i* are discuss$ 9 ! reports t foll[ 7 consid]$ by ! ,c\ncil dur+ ! pa/ ye> because inquiries _h be5 receiv$ 9 reg>d to !m4 ,9 publi%+ ^! reports x is desirable t ! attitude ( ! ,c\ncil t[>d 8mix$0 vacc9es aga9 be /at$4 ,9 view ( ! rapid developm5t ( bact]ial !rapy1 ! possibility = h>m t att5ds ! use ( bact]ial vacc9es & ! skepticism among exp]i5c$ cl9icians z to ! value ( vacc9es repres5t+ a comb9ation ( organisms1 ! ,c\ncil has felt t x %\ld scrut9ize ! claims = su* ag5ts ) exceptional c>e & t !re %\ld be admitt$ to ,new & ,non(ficial ,rem$ies only ^? vacc9e mixtures = :i* !re is acceptable evid5ce to indicate t ! use ( ! p>ticul> mixtures is rational4 ,9 consid]+ ! subject ! ,c\ncil has borne 9 m9d ! fact t 9 _m in/itutions 9 :i* cases are /udi$ & ! results ( !rapeutic measures c>efully obs]v$ & controll$1 vacc9es ( any sort are practically nev] us$--c]ta9ly "h ! /ock mix$ vacc9e has no recognition4 ,exp]i5c$ cl9icians h g5]ally come to ! conclusion t mix$ vacc9es h no specific action & t any effect !y may produce is due to a non-specific prote9 reaction4 ,z set =? 9 ! reports1 9 no case 0 ! evid5ce submitt$ by ! proprietors suffici5t to e/abli% ! claims made = ! prep>ations4 ,h5ce none 0 accept$ = ,new & ,non(ficial ,rem$ies4 ,! prep>ations t =m ! basis = ! accompany+ reports are only a few ( ! _m t are be+ made & sold by "s biological h\ses4 ,d\btless _m ( ^? n dealt ) 9 ?is report are equally irrational & sold "u claims equally--or probably ev5 m--unw>rant$ ?an ^? ) :i* ! pres5t report deals4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,mix$ ,vacc9es-,abbott ,9 response to inquiry ! ,c\ncil und]took a consid]ation ( ! foll[+ 8mix$0 vacc9es sold by ! ,abbott ,laboratories3 ,m4 ,cat>rhalis-,comb9$-,bact]91 said to conta9 kill$ ,micrococcus cat>rhalis1 ,bacillus ,fri$lnd]1 ,pneumococci1 ,/reptococci1 ,/aphylococcus aureus & ,/aphylococcus albus4 ,b4 ,coli-,comb9$-,bact]91 said to conta9 kill$ ,/reptococcus viridans1 ,/reptococcus hemolyticus & ,bacillus coli4 ,p]tussis-,comb9$-,bact]91 said to conta9 kill$ ,bacillus p]tussis1 ,pneumococci1 ,/reptococci1 ,/aphylococcus albus1 ,/aphylococcus aureus & ,micrococcus cat>rhalis4 ,/reptococcus-,rheumaticus-,comb9$-,bact ]91 said to conta9 kill$ 8,/reptococci 7,rheumaticus1 ,viridans1 etc470 & ,pneumococci4 ,/reptococcus-,viridans-,comb9$-,bact]91 said to conta9 kill$ ,/reptococcus viridans1 ,/reptococcus hemolyticus1 ,pneumococcus & ,/aphylococcus albus4 ,! ,abbott ,laboratories 7 ask$ to assi/ 9 ! inve/igation ( ^! products & to submit evid5ce to e/abli% _! eligibility = admission to ,new & ,non(ficial ,rem$ies4 ,! manufactur] 0 in=m$ t ! ,c\ncil accepts 8mix$0 vacc9es or bact]9s1 provid$ ! usefulness ( ^! products is e/abli%$ by acceptable cl9ical evid5ce1 & ref]5ces to ! lit]ature be>+ on ! value ( ! prep>ations 7 reque/$4 ,! ,abbott ,laboratories submitt$ specim5s ( ! products1 ! adv]tis+ matt] !re= & a consid]able li/ ( ref]5ces to curr5t lit]ature2 all ( :i* 0 transmitt$ to ! ,committee on ,s]ums & ,vacc9es = consid]ation4 ,9 due "t a ref]ee ( ! committee submitt$ ! foll[+ report3 ,,! ,,committee',s ,,report ,! ref]ee has /udi$ ! lit]ature cov]$ by ! ref]5ces submitt$4 ,9 g5]al ! articles are favorable to ! use ( vacc9es1 ?\gh _m ( ^! pap]s d n consid] 8mix$0 vacc9es2 inde$1 a numb] ( ! articles d n discuss treatm5t at all1 b are devot$ entirely to ! consid]ation ( etiology ( ! disease4 ,_m ( ! pap]s are by ^? :o are obvi\sly ov]5?usia/ic on ! subject ( ! use ( biologic prep>ations4 ,"o pap]--n includ$ 9 ! ref]5ces submitt$ by ! ,abbott ,laboratories--records an al>m+ reaction foll[+ a dose ( mix$ vacc9e2 no claim is made t improvem5t foll[$4 ,! foll[+ comm5ts on ! submitt$ ref]5ces are (f]$3 ,m4 ,cat>rhalis-,comb9$-,bact]94--,only f\r ( ! n9e ref]5ces giv5 deal ) ! !rapeutic use ( ! vacc9e4 ,! report$ results 9 g5]al 7 favorable1 b sometimes 9 ! discussion evok$ by c]ta9 ( ! pap]s1 views ! rev]se ( ^? express$ by ! au?or 7 br\ght =w>d4 ,! en?usiasm ( "o writ] is %[n 9 8 /atem5t t foll[+ ! use ( vacc9e 9 cases ( c>buncle complicat+ diabetes ! sug> 9 ! ur9e disappe>$ or 0 r$uc$4 ,"o obs]v]1 :o reports excell5t results 9 nasal ph>yngeal cat>rh1 speaks ( c]ta9 vacc9es z 8bulk goods10 :ile ano!r consid]s 8----'s ,no4 #g0 z ! prop] ?+4 ,x is evid5t t ! reports are n bas$ on c>eful1 sci5tific data1 or su* unsci5tific def9ition ( ! product employ$ w\ld n be us$4 ,b4 ,coli-,comb9$-,bact]94--,9 ! ref]5ces cit$ 9 support ( ?is prep>ation ! foll[+ g5]al /atem5ts are not$3 ,"o en?usia/ic writ] says1 8,x mu/ be recogniz$ t we h no satisfactory explanation ( ! action ( vacc9es1 & _! use at pres5t is empirical40 ,"o au?or dwelt on ! sup]iority ( autog5\s vacc9es b admits t occasionally /ock vacc9es are indicat$4 ,"o vacc9e !rapi/ 9 conclud+ an article /ates1 8,x is simply impossible to practice mod]n urology )\t our mod]n biologic products40 ,yet x is a well-kn[n fact t _m successful & capable g5ito-ur9>y surgeons avoid ! use ( vacc9es1 mix$ or simple4 ,p]tussis-,comb9$-,bact]94--,^! reports are uni=mly favorable1 b are n controll$ & _! value is n to be comp>$ ) a rec5t report f ! ,new ,york ,city ,dep>tm5t ( ,heal? :i* indicates t ! vacc9e is practically valueless4 ,x is not$1 fur!r1 t "o ( ! articles cit$ :i* dealt r fully ) ! treatm5t ( p]tussis did n m5tion vacc9es4 ,/reptococcus-,rheumaticus-,comb9$-,bact ]94--,! ref]5ces cit$ 9 support ( ! prep>ations by ! manufactur] give no support :atev] = ! use ( mix$ /ock vacc9es4 ,! fir/ ref]5ce deals ) ! relation ( ,/reptococcus viridans to ar?ritis de=mans & endoc>ditis & reports ! foll[+ cases3 ,case #a4--,vacc9e case--improvem5t aft] eight mon?s4 ,case #b4--,slight improvem5t foll[+ use ( vacc9e4 ,case #c4--,slight improvem5t foll[+ use ( vacc9e4 ,case #d4--,m>k$ improvem5t4 ,case #e4--,prompt improvem5t4 ,case #f4--,vacc9e n m5tion$4 ,case #g4--,vacc9e foll[$ by slight improvem5t4 ,9 ea* ( ! cases o!r me?ods ( treatm5t 7 us$4 ,! pap] %[s ! etiologic relation ( ,/reptococcus viridans r ?an ! value ( vacc9es4 ,!re is no indication t /ock vacc9es 7 us$1 ?\gh ! pap] is n cle> on ?is po9t4 ,! second pap] deals ) ! application ( vacc9e !rapy 9 ! treatm5t ( ar?ritis4 ,?is pap] is by a man :o is av[$ly an en?usia/ on vacc9e !rapy4 ,! indications are t he g5]ally us$ a mix$ autog5\s vacc9e1 b ! reports ( cases are n always cle>4 ,?is writ] app>5tly makes no s]i\s attempt at ! classification ( ! jo9t conditions he treats4 ,! ?ird ref]5ce is a purely exp]im5tal /udy & has no be>+ on ! use ( vacc9es 9 treatm5t4 ,! f\r? article 0 admitt$ by ! manufactur] to be 8negative z reg>ds evid5ce40 ,! fif? ref]5ce specifically /ates t 8! vacc9e mu/ be autog5\s40 ,! six? ref]5ce deals ) ! exp]im5tal production ( app5dicitis by ! use ( diplococci1 & has n ! mo/ remote be>+ on ! use ( vacc9es 9 ! treatm5t ( rheumatism4 ,/reptococcus-,viridans-,comb9$-,bact]94 --,! article :i* be>s evid5ce ( m c>e ?an ! o!rs admits t we are n 9 position to /ate ! value ( vacc9es 9 pyorrhea b ! au?or believes !y may h value supplem5t>y to local treatm5t4 ,x is n surpris+ t a l>ge numb] ( favorable reports c be accumulat$ :5 we appreciate h[ promptly m5 report :at !y consid] to be _! successes & h[ commonly !y leave _! failures unrecord$4 ,be>+ 9 m9d ! fact t ^! /ock mix$ vacc9es1 ?\gh be=e ! pr(ession = _m ye>s1 h n be5 us$1 or cont9u$ 9 use1 9 hospitals :]e "w is rigidly controll$ & t !y are us$ practically n at all 9 ! l>ge gov]nm5t hospital s]vice1 a c&id critic mu/ hold t !re is no sub/antial evid5ce 9 favor ( ! !rapeutic use ( a mix$ vacc9e1 c]ta9ly n = /ock 8goods0 & t probably !re is b a limit$ field = ! employm5t ( autog5\s vacc9es4 ,! ref]ee calls att5tion to a %ift 9 ! adv]tis+ matt] on vacc9es--! t5d5cy to recomm5d vacc9es to be us$ 9 conjunction ) drugs4 ,a head+ 9 ! ,abbott booklet reads1 8,! ,biologics ,d ,n ,replace ,drugs02 & ! p>agraph speaks ( s]ums & bact]9s z 8new tools1 supplem5tal to ^? we already h1 b n replac+ !m40 444 8,we ne$ !m bo?40 ,! ref]ee recomm5ds t ! sev]al mix$ vacc9es discuss$ 9 ?is report be n accept$ on ! gr\nds t satisfactory evid5ce ( _! value is want+4 ,hav+ be5 endors$ by ! ,committee on ,s]ums & ,vacc9es ! ,c\ncil adopt$ ! report & decl>$ ,m4 ,cat>rhalis-,comb9$-,bact]91 ,b4 ,coli-,comb9$-,bact]91 ,p]tussis-,comb9$-,bact]91 ,/reptococcus-,rheumaticus-,comb9$-,bact ]9 & ,/reptococcus-,viridans-,comb9$-,bact]9 ineligible = admission to ,new & ,non(ficial ,rem$ies4 ,cat>rhal ,vacc9e ,comb9$-,lilly & ,influ5za ,mix$ ,vacc9e-,lilly ,because ( inquiry receiv$1 ! ,c\ncil reque/$ ,eli ,lilly & ,company to aid 9 det]m9+ ! acceptability ( ! foll[+ products = ,new & ,non(ficial ,rem$ies3 8,cat>rhal ,vacc9e ,comb9$10 said to conta9 kill$ cultures ( ! ,bacillus ( ,fri$lnd]1 ,micrococcus cat>rhalis1 ,/aphylococcus aureus & albus1 ,pneumococcus & ,/reptococcus2 8,influ5za ,mix$ ,vacc9e10 said to conta9 kill$ cultures ( ,/aphylococcus albus & aureus1 ,/reptococcus1 ,pneumococcus1 ,micrococcus cat>rhalis & ,bacillus influ5zae4 ,lilly & ,company s5t ! circul>s1 etc41 us$ 9 adv]tis+ ^! products4 ,a circul> = 8,cat>rhal ,vacc9e ,comb9$0 conta9$ ! foll[+ claim3 8,cat>rhal ,vacc9e has be5 especially useful 9 _m respiratory infections1 includ+ bron*itis1 ph>yngitis1 rh9itis1 *ronic cat>rh & 9 ! mix$ infections ( pulmon>y tub]culosis40 ,a circul> = 8,influ5za ,mix$ ,vacc9e0 conta9$ ! foll[+3 8,! vacc9e is useful 9 ! treatm5t ( influ5za & ord9>y colds1 & 9 any infection 9 :i* ! ,bacillus influ5zae is ! causative ag5t40 ,an adv]tis+ pamphlet conta9$ ! foll[+3 8,cat>rh1 ,acute & ,*ronic2 ,colds1 ,influ5za4--,! micro-organisms capable ( produc+ cat>rhal conditions ( ! nose & ph>ynx & mo/ commonly isolat$ are ,b4 ,fri$lnd]1 ,m4 cat>rhalis1 /aphylococcus1 pneumococcus 79 infections beg9n+ 9 ! l>ynx71 ,b4 influ5za & /reptococcus4 ,^! organisms are f\nd normally 9 ! respiratory passages & acquire virul5ce only :5 resi/ance has be5 l[]$ ?r\gh ov]work1 exposure to cold1 etc4 8,! results foll[+ ! use ( ,cat>rhal ,vacc9e ,comb9$ 79 ! non-epidemic =ms7 & influ5za ,mix$ ,vacc9e 79 ! epidemic types7 h be5 v satisfactory1 due to ! great vascul>ity ( ! tissues4 ,acute attacks are abort$ altoge!r or %ort5$ 9 duration & ! dang] ( complications greatly m9imiz$40 ,no evid5ce 0 submitt$ :i* w>rants ! prec$+ claims nor is ! ,c\ncil aw>e ( any reliable te/imony to indicate t ! adm9i/ration ( ! mixture "h discuss$ is w>rant$ or desirable4 ,on ! recomm5dation ( ! ,committee on ,s]ums & ,vacc9es ! ,c\ncil vot$ t 8,cat>rhal ,vacc9e ,comb9$-,lilly0 & 8,influ5za ,mix$ ,vacc9e-,lilly0 be n includ$ 9 ,new & ,non(ficial ,rem$ies because satisfactory evid5ce ( _! value is want+4 ,influ5za ,s]obact]9 ,mix$-,mul=d ,because ( inquiry receiv$1 ! ,c\ncil took up ! consid]ation ( 8,influ5za ,s]obact]9 ,mix$-,mul=d10 & reque/$ ! ,mul=d ,company to pres5t evid5ce to e/abli% ! admissibility ( ! prep>ation to ,new & ,non(ficial ,rem$ies4 ,! ,mul=d ,company s5t specim5s ( ! s]obact]9 9 "q1 an adv]tis+ circul> & a lett] by ! director ( its ,biologic ,laboratories4 ,accord+ to ! label on ! package1 ! prep>ation is made f ! foll[+ organisms3 ,bacillus influ5zae1 ,/aphylococcus aureus1 ,/aphylococcus albus1 ,/reptococcus1 ,pneumococcus & ,micrococcus cat>rhalis 7gr\p74 ,?is mixture is recomm5d$ by ! manufactur]3 8,= ! prophylaxis & ,treatm5t ( ,common ,colds1 ,mix$ ,infections ( ! ,respiratory ,muc\s ,membranes1 ,acute & ,*ronic ,cat>rhal ,conditions ( ! ,nose1 ,?roat & ,respiratory ,passages40 ,no evid5ce is submitt$ = ?is recomm5dation except t 9 8colds & bron*itis & ! o!r common infections ( ! upp] respiratory passages 444 five or six bact]ia are v commonly pres5t--two or m ( !m are ne>ly always pres5t 4440 & ! lett] by ! director ( ! ,mul=d ,biologic ,laboratories express+ ! belief t 9 8 own case ! use ( ! mix$ vacc9e has abort$ or prev5t$ colds4 ,z reg>ds ! use ( ?is complex biologic prep>ation3 ,fir/1 ! cause ( common colds is1 at ! pres5t "t1 q unkn[n4 ,"o ( ! mo/ /rik+ ?+s is t at ! beg9n+ ( a cold ! organisms to be cultivat$ f ! nasal muc\s membrane are v few 9 numb] & !re is no uni=mity 9 ! type ( organism f\nd4 ,if someone ( ! well-kn[n organisms 7,/reptococcus1 ,/aphylococcus1 ,pneumococcus1 ,micrococcus ,cat>rhalis1 ,influ5za ,bacillus1 etc47 7 responsible1 we %\ld expect to f9d "o ( !m prepond]at+ & 9 ov]:elm+ numb]s4 ,?is is f> f ! case4 ,aft] ! duration ( ! cold = a day or two ) ! increas$ production ( mucus & app>5tly ) ! infection ( a muc\s membrane ^: p[]s ( resi/ance h be5 greatly l[]$1 bact]ia ( all k9ds are to be f\nd 9 imm5se numb]s4 ,!re is consid]able reason = believ+ t an ultramicroscopic organism is responsible = ?is condition 7,see ,fo/]1 ,j\rnal ( ,infecti\s ,diseases #ba3dea ,nov4 #aiag74 ,second1 !re is no acceptable cl9ical evid5ce t vacc9ation ) ! influ5za bacillus1 ! ,/reptococcus1 ! ,pneumococcus or ! ,micrococcus ,cat>rhalis w influ5ce ! c\rse ( an infection due to "o or ! o!r ( ^! organisms4 ,x has be5 repeat$ly f\nd t a /aphylococcus vacc9e is ( a c]ta9 degree ( value :5 ! infection ) ! /aphylococcus is localiz$1 b x is well kn[n t g5]al sy/emic infections ) ! /aphylococcus are n at all b5efit$4 ,?ird1 ! lett] submitt$ z evid5ce by ! ,mul=d ,company is n conv9c+4 ,! ,c\ncil is n prep>$ to accept evid5ce ( ?is sort unless x is 9 volume l>ge en\gh to ju/ify a def9ite conclusion4 ,hold+ t !re is no evid5ce = ! value ( ?is mixture1 ! ,c\ncil decl>$ 8,influ5za ,s]obact]9 ,mix$-,mul=d0 inadmissible to ,new & ,non(ficial ,rem$ies because its use is illogical4 ,%]man's ,mix$ ,vacc9e ,no4 #dj ,because ( inquiry receiv$ ! ,c\ncil decid$ to consid] ?is prep>ation & reque/$ ! manufactur]1 ,g4 ,h4 ,%]man1 ,detroit1 ,mi*41 to submit evid5ce 9 support ( ! claims made = x4 ,?is vacc9e is said to be made f kill$ cultures ( ,/reptococcus1 ,pneumococcus1 ,micrococcus cat>rhalis1 ,/aphylococcus aureus1 & ,/aphylococcus albus4 ,9 ! pr9t$ matt] s5t out by ,g4 ,h4 ,%]man ?is vacc9e is recomm5d$ = hay-fev]1 9 :i* x is /at$ t "s ( ! symptoms are due to bact]ial invasion ( ! respiratory mucosa2 = tonsillitis1 bo? z a rem$y & z a prophylactic aga9/ rheumatic & o!r sequelae2 = 8?roat infections02 = rh9itis ) ! claims t acute coryza c be abort$ )9 tw5ty-f\r h\rs2 = pneumonia 9 :i* x is advis$ = all /ages2 = l>yngitis1 = bron*itis1 & = a/hma4 ,no acceptable evid5ce 0 submitt$ z to ! value ( ! product 9 ! treatm5t ( any ( ! =ego+ conditions4 ,9 view ( :at is kn[n ab\t non-specific reactions1 x seems likely t any influ5ce :i* ?is vacc9e may h on ! div]se conditions enum]at$ by ! manufactur]1 is due to ?is1 r ?an to ! comb9ation ( organisms us$ 9 its prep>ation4 ,on ! recomm5dation ( ! ,committee on ,s]ums & ,vacc9es1 ! ,c\ncil decl>$ 8,%]man's ,mix$ ,vacc9e ,no4 #dj0 ineligible to ,new & ,non(ficial ,rem$ies because ! !rapeutic claims made = x are unw>rant$ 7,rule #f7 & because ! comb9ation1 9 view ( its complexity1 is irrational & detrim5tal to s\nd !rapy 7,rule #aj74--7;,f ,! ,j\rnal ,a4 ,m4 ,a41 ,june #bc1 #aiah47 ,,oph?almol-,,l9demann ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,oph?almol-,l9demann 0 tak5 up = consid]ation by ! ,c\ncil because ( inquiries receiv$4 ,! foll[+ report1 decl>+ ,oph?almol inadmissible to ,new & ,non(ficial ,rem$ies1 0 adopt$ by ! ,c\ncil & its publication au?oriz$4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,oph?almol-,l9demann 7,innis1 ,speid5 & ,co41 ,new ,york7 is adv]tis$ z a treatm5t = eye diseases by 8hyp]emia40 ,! circul> adv]tis+ ! product is writt5 some:at 9 ! /yle ( 8pat5t m$ic9e0 adv]tisem5ts4 ,x conta9s te/imonials ( dubi\s value4 ,! pr9ciple und]ly+ ! use ( ,oph?almol is t employ$ to a consid]able ext5t by oph?almologi/s1 ?r\gh ! use ( e?ylmorph9e 78dion9071 etc41 viz41 ! production ( conjunctival irritation 9 inflammatory eye diseases4 ,oph?almol is1 !re=e1 m]ely a special ag5t = ! production ( su* oph?almic irritation4 ,! adv]tis+ circul> conta9s no evid5ce t ,oph?almol is 9 any respect sup]ior to ! e/abli%$ ag5ts = produc+ conjunctival hyp]emia4 ,on ! o!r h&1 !re are obvi\s objections to ! use 9 ! eye ( a sub/ance ( unkn[n & app>5tly indef9ite composition & unc]ta9 activity4 ,oph?almol is said to be an oily solution ( 8gl&ul> extract ( ! fi% ,cobitis ,fossilis40 ,cobitis fossilis is a small fi% said to be common 9 ,g]many4 ,accord+ to ,ko*s1 :o analyz$ ,oph?almol 7,arb4 a4 d4 ,ph>m4 ,in/4 d4 ,univ4 ,b]l41 #d3adj1 #aijg71 ?is fi% is popul>ly believ$ to pr$ict wea!r1 b m$ical virtues are n ascrib$ to x4 ,?is 8fi%y0 extract is indef9ite1 to say ! lea/4 ,! activity ( ! prep>ation is describ$ by ! manufactur] ?us3 8,x seems probable t ! typical action ( ,oph?almol is due to c]ta9 organic acids :i* may h =m$ dur+ manufacture ?r\gh ! decomposition ( prote9 bodies conta9$ 9 ! crude mat]ial40 ,! pr(ession is n told :e!r ?is important decomposition is1 or1 9 fact1 c be controll$ s z to produce a mat]ial ( uni=m activity4 ,ko*s conclud$ f 8 analysis t ,oph?almol _h ! prop]ties ( rancid olive oil conta9+ ab\t #f to #g p] c5t4 m9]al oil4 ,! oil conta9$ no nitrog51 left no a% on ignition & ?\gh traces ( iod9 7 claim$ to be pres5t1 no iod9 c\ld be f\nd4 ,x is recomm5d$ t ,oph?almol be reject$ fir/1 because ! use 9 ! eye ( an irritant ( secret composition & unc]ta9 activity is unsci5tific & aga9/ ! int]e/ ( public heal?2 second1 because ,oph?almol is ( secret composition 7! composition claim$ be+ practically mean+less71 &1 ?ird1 because no evid5ce has be5 submitt$ to sub/antiate its claim$ sup]iority ov] e/abli%$ me?ods ( treatm5t4 ,! ,c\ncil decl>$ ,oph?almol inadmissible to ,new & ,non(ficial ,rem$ies4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,july #f1 #aiah47 ,,silvol ,,ineligible ,,= ,n4 ,n4 ,r4 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! foll[+ report on ,silvol 7,p>ke1 ,davis ,company7 0 adopt$ by ! ,c\ncil & its publication au?oriz$4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,! ,c\ncil took up ! consid]ation ( ,silvol 7,p>ke1 ,davis ,company7 because ( inquiries receiv$4 ,! foll[+ report 0 submitt$ by ! ref]ee 9 *>ge ( silv] prep>ations3 ,silvol 7,p>ke1 ,davis ,company7 is a silv]-prote9 prep>ation ( ! ,argyrol type4 ,l ,argyrol1 x is said to conta9 ab\t #bj p] c5t4 ( silv]4 ,! ref]ee f9ds t1 l ,argyrol1 x is nonirritant to ! nasal mucosa 9 a #aj p] c5t4 solution2 does n precipitate ) *lorid2 dissolves 9 wat] readily2 a #be p] c5t4 solution has a high specific gravity 7,silvol1 #a4acg at #bj ,c42 ,argyrol1 #a4adg at #bj ,c471 & is n v viscid 7viscosity1 #a4be74 ,a #a3a1jjj solution ( ,silvol is cle> & ab\t #ej p] c5t4 deep] 9 color ?an a solution ( ,argyrol ( ! same /r5g?4 ,silvol diff]s f ,argyrol ma9ly 9 t its solutions yield a f9e precipitate ) egg album9 7"u suitable conditions71 :ile ,argyrol is nonprecipitant2 & 9 t ,silvol solutions are n s effectively decoloriz$ by ,lloyd's reag5t4 ,! manufactur]s did n reply to an inquiry ) reg>d to ! basis = ! claims made = ,silvol 7see ,app5dix74 ,! ref]ee 0 !re=e oblig$ to d$uce ^! claims f ! firm's adv]tis+ matt]4 ,ab\t ! same claims are made = ! local use ( ,silvol z are g5]ally made = ,argyrol4 ,^! may be accept$ )\t detail$ evid5ce 9 view ( ! simil>ity ( ! two prep>ations4 ,its usefulness1 z sugge/$ 9 ! adv]tis+1 :5 giv5 by m\? 89 ! treatm5t ( acute or *ronic ga/ritis1 ga/ric ulc]1 or ga/ro-ent]itis10 or ! efficacy ( v dilute solutions 7#j4b p] c5t47 aga9/ dys5t]y1 etc41 is d\btful & requires sub/antiation by evid5ce4 ,! claims t ,silvol is a/r+5t1 ?\gh nonirritant & noncoagulant1 t x is a 8p[]ful g]micide0 or ev5 t x is a 8p[]ful antiseptic10 & t x may be us$ ) advantage :]ev] 8a silv] salt is indicat$10 ne$ sub/antiation4 ,!re is no pro( ( ! ass]tions t ,silvol is 8! mo/ efficaci\s ( silv] salts02 8! mo/ effici5t antiseptic10 & 8! mo/ rem>kable organic silv] comp\nd 4440 ,z ! manufactur]s h n pres5t$ any evid5ce = _! highly improbable claims1 & z !y h n signifi$ any int5tion ( mak+ _! claims agree ) sub/antiat$ facts1 x is recomm5d$ t ,silvol be decl>$ inadmissible to ,new & ,non(ficial ,rem$ies4 ,! ,c\ncil adopt$ ! report ( its ref]ee & au?oriz$ its publication4 ,,app5dix ,! foll[+ lett] f ! ,secret>y ( ! ,c\ncil 0 s5t to ,p>ke1 ,davis ,company1 ,m>* #bj1 #aiag4 ,no reply to x has be5 receiv$3 ,! ref]ee ( ! ,c\ncil :o is conduct+ an inve/igation ( silv] prep>ations ask$ me to inquire if y are will+ to submit y\r evid5ce = ! foll[+ claims :i* are made 9 y\r circul>s = ,silvol3 #a4 ,h[ x is possible = ! solution to be a/r+5t1 & at ! same "t nonirritant & noncoagulant8 #b4 ,t inte/9al irrigation ) a ,silvol solution conta9+ #aj to #ae gra9s to ! p9t is suffici5tly bact]icidal to 8be us$ 9 ! abortive treatm5t ( su* infecti\s processes z dys5t]y1 *ol]a infantum1 & colitis40 #c4 ,:at evid5ce h y z to ! degree ( antiseptic & g]micidal p[] ( ,silvol solutions8 #d4 ,:at evid5ce h y z to ! degree ( antiseptic & g]micidal p[] ( #e p] c5t4 ,silvol ,o9tm5t8 ,a reply to ! above que/ions & any o!r in=mation 9 reg>d to ,silvol w receive c>eful consid]ation4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,july #ac1 #aiah47 ,,ka?>mon ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,foll[+ inquiries1 ! ,c\ncil took up 8,ka?>mon0 = consid]ation & au?oriz$ publication ( ! foll[+ report4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,! ,ka?>mon ,*emical ,company ( ,/4 ,l\is 9 adv]tis+ its ,ka?>mon appeals especially to a pr(ession ^: memb]s1 %\ld !y live up to _! e?ical code1 c\ld n prescribe x4#abd ,9 #ahic 7:5 ! publication ( 8a =mula0 = propriet>y prep>ations 0 ?\ght to satisfy ! requirem5ts ( sci5tific m$ic9e7 an adv]tisem5t 9 ,! ,j\rnal ( ! ,am]ican ,m$ical ,association gave ! foll[+ 8=mula0 = ,ka?>mon3 #abd 8444 x is equally une?ical to prescribe or disp5se secret m$ic9es or o!r secret rem$ial ag5ts14440 ,sec4 #f1 ,art4 ,i1 ,*apt] ,,ii1 ,pr9ciples ( ,m$ical ,e?ics4 8,hydra/is ,canad5sis1 ,phytolacca ,dec&ra1 ,acid ,salicyl\s ,c4 ,p4 7f ,oil ( ,w9t]gre571 ,acid ,boric ,c4 ,p41 ,m5?a ,arv5sis1 ,?ymus ,vulg>is1 ,di/4 ,ext4 ,hamamelis ,virg4 ,conc40 ,9 #aijg an adv]tisem5t 9 ! ,kansas ,city ,m$ical ,index-,lancet decl>$ t3 8,ka?>mon repres5ts 9 *emical comb9ation ! active pr9ciples ( ,hydra/is ,canad5sis1 ,gaul!ria ,procumb5s1 ,hamamelis ,virg9ica1 ,phytolacca ,dec&ra1 ,m5?a ,arv5sis1 ,?ymus ,vulg>is1 ) two gra9s ,c4 ,p4 ,boric ,acid to ea* fluid dra*m40 ,n[ ! adv]tisem5ts :i* appe> 9 "s m$ical j\rnals /ate3 8,,ka?>mon repres5ts 9 comb9ation ,hydra/is ,canad5sis1 ,?ymus ,vulg>is1 ,m5?a ,arv5sis1 ,phytolacca ,dec&ra1 #aj-a_/b gra9s ,acid ,borosalicylic1 #bd gra9s ,sodium ,pyroborate to ea* fluid ounce ( ,pure ,di/ill$ ,extract ( ,wit* ,hazel40 ,a comp>ison ( ^! s-call$ =mulas %[s t !y h n only v>i$ f "t to "t1 b t 9 no in/ance 0 a quantitative /atem5t ) reg>d to all ! ass]t$ +r$i5ts giv54 ,! ,*emical ,laboratory ( ! ,a4 ,m4 ,a4 reports3 ,ka?>mon has an alkal9e reaction & !re=e _c conta9 boric acid1 salicylic acid or 8borosalicylic acid0 7! latt] is unkn[n to m$ical lit]ature except z loosely appli$ to a simple mixture ( boric & salicylic acids74 ,! solution gives te/s = sodium1 borate1 & salicylate & !re=e probably conta9s sodium borate & sodium salicylate4 ,exam9$ by ! me?ods us$ = ! det]m9ation ( hydra/9 9 gold5seal prep>ations1 a residue giv+ only a fa9t te/ = alkaloid 0 obta9$2 if pres5t at all1 hydra/is canad5sis 7gold5seal7 is !re only 9 v small am\nts4 ,a circul> wrapp$ ) ! trade package ( ,ka?>mon conta9$ ! foll[+1 palpably unw>rant$1 claims3 8,,int]nally x is v useful 9 acute indige/ion1 ,ga/ric ,cat>rh1 ,di>rhoea & ,*ol]a ,infantum40 8444 x has demon/rat$ its rem>kable curative effects1 n only 9 prev5t+ unheal?y conditions ( fre% w\nds1 b also 9 correct+ ! decay+ ( putrefactive processes peculi> to ! body "u c]ta9 circum/ances4 ,x has1 fur!r1 a rem>kable efficacy 9 surface inflammations1 :e!r produc$ by accid5t or disease1 & is an indisp5sable rem$y 9 ! affections ( ! muc\s membranes ( ! nose1 m\?1 /oma*1 b[els1 vag9a1 ut]us1 ure?ra1 bladd] & rectum40 ,ka?>mon is 9 conflict ) ,rules #a & #d ( ! ,c\ncil on ,ph>macy & ,*emi/ry because ( its indef9ite & secret composition & ! me?od ( adv]tis+ x indirectly to ! public2 x is 9 conflict ) ,rules #aj1 #f & #h1 9 t x is an irrational %otgun mixture sold "u unw>rant$ !rapeutic claims & "u a "n nondescriptive ( its composition4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,aug4 #aj1 #aiah47 ,,iod9iz$ ,,emulsion 7,,scott7 ,,& ,,creosotonic 7,,scott7 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry 8,iod9iz$ ,emulsion 7,scott70 & 8,creosotonic 7,scott70 are propriet>y prep>ations ( ! ,dawson ,ph>macal ,company1 ,dawson ,spr+s1 ,ky4 ,! latt] prep>ation us$ to be kn[n z 8,iod9iz$ ,emulsion 7,scott7 ) ,hypophosphites1 ,guaiacol & ,creosote40 ,9 #aijg ^! prep>ations 7 consid]$ by ! ,c\ncil & f\nd inadmissible to ,new & ,non(ficial ,rem$ies4 ,exam9ation ( ! prep>ations hav+ be5 aga9 reque/$1 ! ,c\ncil consid]$ !m anew because ! composition & claims _h be5 *ang$ some:at & because at ! previ\s consid]ation no report 0 publi%$4 ,! reports :i* appe> bel[ 7 s5t to ! ,dawson ,ph>macal ,company = comm5t be=e publication4 ,9 reply ! company (f]$ to revise its claims = ! prep>ations4 ,! ,c\ncil repli$ t ! report s5t expla9$ t bo? prep>ations are irrational mixtures1 & h5ce a revision ( ! claims w\ld n make !m eligible = ,new & ,non(ficial ,rem$ies4 ,x advis$ t publication ( ! report w\ld be )held sixty days & t x w\ld be revis$ if new in=mation or evid5ce 0 submitt$ p]mitt+ su* revision4 ,aft] expiration ( ! /ipulat$ po/ponem5t1 ! ,dawson ,ph>macal ,company wrote t no new adv]tis+ matt] _h be5 prep>$1 b t ! old circul>s 7 n be+ s5t out4 ,z ^! irrational prep>ations 7 /ill sold & adv]tis$ to ! m$ical pr(ession & presumably us$ by "s physicians1 ! ,c\ncil direct$ publication ( its report ) ?is explanation4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,iod9iz$ ,emulsion 7,scott7 ,! label = ,iod9iz$ ,emulsion 7,scott7 decl>es3 8,ea* fluidram conta9s3 ,alcohol1 m4 #d-c_/d2 ,rectifi$ ,ol4 ( ,turp5t9e1 m4 #c-a_/b2 ,iod91 gr4 #a_/h2 ,ph5ol1 gr4 #a_/b2 ,glyc]9e & ,elixir ,lactat$ ,peps9 ) ,aromatic ,oils 9 ! =m ( a p]fect emulsion40 ,a circul> :i* gives :at is ass]t$ to be ! composition ( ,iod9iz$ ,emulsion1 decl>es t1 among o!r +r$i5ts1 ea* fluidram conta9s 8"o & ?ree qu>t]s m4 ,t9cture ( ,iod9e40 ,bo? ! /atem5t on ! label t ! prep>ation conta9s 8iod90 & ! "o 9 ! circul> t t9cture ( iod9 is pres5t 9 ! product are incorrect1 = ! ,a4 ,m4 ,a4 ,*emical ,laboratory reports t no free iod9 c\ld be detect$ 9 ! prep>ation1 & t x respond$ to te/s = iodid in/ead4 ,an adv]tis+ circul> = ,iod9iz$ ,emulsion 7,scott7 makes unw>rant$ claims = ! !rapeutic prop]ties ( ! con/itu5ts4 ,= example3 8444 ! great usefulness ( ,turp5t9e 9 diseases1 especially ( ! ,inte/9al ,infection1 su* z ! ,meteorism & ,tympanites ( ,typhoid40 ,& ?is absurdity3 8444 :]e ,turp5t9e1 ,c>bolic ,acid or ,iod9e or ev5 ,peps9 is indicat$1 t x w give satisfaction 9 ea* & e case40 ,iod9iz$ ,emulsion 7,scott7 is n a 8ph>maceutical triumph02 x is an irrational mixture--a rem9d] ( a decad5t polyph>macy--sold "u mislead+ & unw>rant$ claims4 ,x is inadmissible to ,new & ,non(ficial ,rem$ies = conflict ) ,rules #a1 #f1 #h & #aj4 ,creosotonic 7,scott7 ,creosotonic 7,scott71 adv]tis$ z a 8recon/ructive tonic0 = ! tub]cul\s1 accord+ to ! label1 conta9s 9 ea* fluidram3 8,alcohol1 m4 #b-a_/b2 ,creosote & ,guaiacol sulphonates ( ea*1 gr4 #a2 ,comp\nd ,hypophosphites1 gr4 #a 7includ+ ,qu99e ,hypophosphites1 gr4 #a_/cf & ,/ry*n9e ,hypophosphites1 gr4 #a_/bef71 ) ,iod9iz$ ,emulsion 7,scott7 m4 #cj40 ,z 9 ! case ( ,iod9iz$ ,emulsion 7,scott71 ! adv]tis+ makes exagg]at$ !rapeutic claims = ! individual con/itu5ts ( ! prep>ation & = ! het]og5e\s mixture ( guaiacol & creosote sulphonates1 hypophosphites1 qu991 /ry*n91 turp5t9e1 ph5ol1 iod91 8lactat$ peps910 etc4 ,?us1 :ile x is well e/abli%$ t 9 guaiacol sulphonate & creosote sulphonate ! ph5olic con/itu5t is b\nd s firmly t1 :5 adm9i/]$1 b v little is split (f 9 ! organism1 yet ! adv]tis+ claims 8t ! sy/em c be saturat$ 9 a %ort] "t & ) small] doses ( creosote & guaiacol sulphonates ?an ) any o!r =m ( ^! drugs0 & t 7on ! false premise t ! guaiacol & creosote f ^! drugs w p]meate ! tissues ( ! lungs7 8!y help to cle> up ! local infection & ?us aid 9 return+ to normal ! diseas$ muc\s membrane40 ,9 ! adv]tis+ pamphlet1 foll[+ a discussion ( ! effect ( climate & food 9 ! treatm5t ( ! tub]cul\s1 we read3 8,:ile admitt+ ! great importance ( ! =ego+ po9ts1 we are firmly ( ! op9ion t prop] m$ication is a great aid 9 ! treatm5t ( pulmon>y tub]culosis1 &1 ) ?is 9 view1 we (f] to ! pr(ession ,creosotonic 7,scott7 believ+ t 9 x we h a sup]ior prep>ation = ?is purpose40 ,?is is unw>rant$4 ,( c\rse suitable m$ication to meet special conditions is prop] 9 ! treatm5t ( tub]culosis1 b ! r\t9e adm9i/ration ( a complex & irrational mixture su* z ,creosotonic 7,scott7 is b\nd to cause inatt5tion to ! prime requisites = ! prop] treatm5t ( ! tub]cul\s--hygi5ic surr\nd+s & good food4 ,creosotonic 7,scott7 is an irrational mixture1 sold "u mislead+ & unw>rant$ claims4 ,x is inadmissible to ,new & ,non(ficial ,rem$ies = conflict ) ,rules #a1 #f1 #h & #aj4--7;,f ,! ,j\rnal ,a4 ,m4 ,a41 ,aug4 #bd1 #aiah47 ,,campetrod9 ,,& ,,campetrod9 ,,no4 #b ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! foll[+ report on ,campetrod9 & ,campetrod9 ,no4 #b has be5 adopt$ by ! ,c\ncil & its publication au?oriz$4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,! foll[+ report ( ! ,a4 ,m4 ,a4 ,*emical ,laboratory on 8,campetrod90 & 8,campetrod9 ,no4 #b10 sold by ! ,a4 ,h4 ,rob9s ,company1 ,ri*mond1 ,va41 0 submitt$ to ! ,c\ncil by a ref]ee ( ! ,committee on ,ph>macology3 ,campetrod9 & ,campetrod9 ,no4 #b1 ,d\ble ,/r5g?1 are call$ 8e?ical m$ic9al specialties0 by ! ,a4 ,h4 ,rob9s ,company1 ,ri*mond1 ,va41 :i* sells !m4 ,an adv]tisem5t 9 ! ,m>yl& ,m$ical ,j\rnal 7,decemb]1 #aiag7 conta9s ! foll[+ claim = composition3 8,,campetrod9 7,made 9 ,two ,/r5g?s ( ,iod9e74 ,?is prep>ation is an ,oleag9\s ,solution ( ,iod9e 9 ,camphor40 ,a booklet describ+ ! 8specialties0 ( ! ,rob9s ,company conta9s ! foll[+ 9 ref]5ce to ,campetrod93 8,composition3 ,camphor1 ,iod9e ,elem5t1 ,oleag9\s ,solv5t40 ,f ?is x appe>s t ! prep>ations are claim$ to conta9 elem5t>y 7free7 iod9e 9 an 8oleag9\s solv5t40 ,s9ce free iod91 z is well kn[n1 readily comb9es ) fats1 x 0 decid$ to det]m9e ! =m 9 :i* ! iod9 0 pres5t 9 ^! prep>ations4 ,! exam9ation demon/rat$ t bo? prep>ations conta9$ b a trace ( free iod94 ,on /eam di/illation !re 0 obta9$ f bo? prep>ations a di/illate am\nt+ to ab\t #ce p] c5t4 by volume :i* _h an odor /rongly sugge/ive ( turp5t9e1 :ile ! residue conta9$ ! iod9 & _h ! *>act]i/ics ( an iodiz$ fatty oil4 ,quantitative det]m9ations indicat$ t ,campetrod9 conta9$ approximately #j4jc p] c5t4 ( free iod9 & #a4c p] c5t4 ( iod9 9 comb9ation ) ! fatty oil4 ,campetrod9 ,no4 #b1 ,d\ble ,/r5g?1 conta9$ approximately #j4jc p] c5t4 free iod9 & #b p] c5t4 ( iod9 9 comb9ation ) ! fatty oil4 ,?us1 contr>y to ! publi%$ /atem5ts1 ,campetrod9 is n a prep>ation ( free 7elem5t>y7 iod9 & ,campetrod9 ,no4 #b1 ,d\ble ,/r5g?1 does n conta9 twice z mu* iod9 z ,campetrod94 ,! report ( ! ,*emical ,laboratory %[s t ! /atem5ts made 9 reg>d to ! composition ( ,campetrod9 & ,campetrod9 ,no4 #b are incomplete 9 "s respects & false 9 o!rs4 ,9 view ( ! ,laboratory's f9d+s x appe>s sup]flu\s to inquire into ! !rapeutic claims made = ! prep>ations3 ,x is evid5t1 h[ev]1 t a solution conta9+ practically no free iod9 is n1 z claim$ by ! ,rob9s ,company1 8adapt$ = use :]ev] 444 iod9 is indicat$ ext]nally44440 ,x is recomm5d$ t ,campetrod9 & ,campetrod9 ,no4 #b be decl>$ inadmissible to ,new & ,non(ficial ,rem$ies because ( false /atem5ts z to *emical composition & !rapeutic action1 con/itut+ conflicts ) ,rules #a & #f4 ,! ,c\ncil adopt$ ! recomm5dation ( ! ref]ee & au?oriz$ publication ( ?is report4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,sept4 #ba1 #aiah47 ,,c>m9zym ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has au?oriz$ publication ( ! foll[+ :i* expla9s :y ,c>m9zym 0 n accept$ = ,new & ,non(ficial ,rem$ies4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,c>m9zym is a tablet sold by ,fair*ild ,bros4 & ,fo/]1 ,new ,york4 ,ea* tablet conta9s1 accord+ to claims made1 approximately #cb mg4 ( an extract ( pancreas1 #ej mg4 sodium bic>bonate1 #agb mg4 prep>$ *alk1 #a4e mg4 p[d]$ ipecac & 8aromatics q4 s40 ,)\t consid]+ o!r possible conflicts ) its rules1 ! ,c\ncil held ! prep>ation inadmissible to ,new & ,non(ficial ,rem$ies = conflict ) ,rule #aj :i* holds t unsci5tific or useless articles are n acceptable products4 ,! ,c\ncil holds t complex mixtures ( rem$ial ag5ts are1 f e po9t ( view1 inimical to !rapeutic progress & !re=e to ! public welf>e4 ,su* mixtures are especially objectionable because x is impossible accurately to det]m9e ! effects :i* foll[ ! simultane\s adm9i/ration ( a numb] ( drugs hav+ dissimil> actions2 because ! practice ( prescrib+ su* mixtures t5ds to disc\rage c>eful consid]ation ( ! special ne$s ( individual pati5ts )\t :i* !re c be no rational drug !rapy4 ,on ! contr>y1 ) ! use ( su* mixture !rapeutic treatm5t becomes haphaz>d & m]e guesswork4 ,! ,c\ncil1 appreciat+ t long e/abli%$ cu/oms _c be *ang$ at once1 has appli$ ,rule #aj conc]n+ ! recognition ( mixtures ) ! greate/ l5i5cy compatible ) consi/5cy4 ,:5 !re has be5 a reasonable d\bt conc]n+ ! value ( a mixture x has frequ5tly direct$ t ,rule #aj %\ld n apply p5d+ fur!r cl9ical trial ( su* mixture4 ,9 no in/ance has subsequ5t exp]i5ce %[n t a /rict int]pretation ( ! rule w\ld h work$ h>d%ip or inju/ice4 ,! ,c\ncil feels t !re is no long] w>rant = ! admission ( complex mixtures to ,new & ,non(ficial ,rem$ies or = ! ret5tion ( any t h be5 admitt$ unless def9ite evid5ce ( ! !rapeutic value ( su* comb9ations is available4 ,9 accordance ) ?is decision sev]al mixtures n[ describ$ 9 ,new & ,non(ficial ,rem$ies w be omitt$ at ! expiration ( ! ?ree ye> p]iod = :i* articles are accept$4 ,rev]t+ to ! ,c>m9zym tablet3 ,:5 x is desir$ to obta9 ! effects ( pancreatic extract by oral adm9i/ration x mu/ be adm9i/]$ ) a view ( prev5t+ its de/ruction by ! ga/ric fluid4 ,) ?is end 9 view an antacid %\ld be adm9i/]$ to decrease ! acidity ( ! ga/ric juice4 ,! am\nt ( alkali may be suppli$ 9 ! =m ( any ( ! (ficial prep>ations1 b ! am\nt mu/ be adju/$ to ! individual pati5t = ! reason t no two successive pati5ts are likely to h ! same degree ( ga/ric acidity4 ,ipecac has a well def9$ ?\gh limit$ field ( usefulness4 ,:5 x is us$1 x %\ld be giv5 ) a due reg>d to ! am\nt ne$$ by ! pati5t & ! frequ5cy ( ! repetition ( ! dose4 ,!re is no reason to suppose t any two successive pati5ts w require ipecac & extract ( pancreas 9 a fix$ proportion & ) equal frequ5cy4 ,z a matt] ( fact1 ! am\nt ( ipecac 9 ,c>m9zym is s small t no def9ite !rapeutic action c be assign$ to x & its use 9 ?is comb9ation is purely empirical4 ,9 a ^w1 ! employm5t ( mixtures ( pancreatic extract1 alkalis1 ipecac & c>m9atives 9 fix$ proportion leads to slip%od treatm5t & irrational !rapeutics4 ,c>m9zym is an irrational mixture ! use ( :i* is detrim5tal to !rapy4 ,! prec$+ report 0 s5t to ,fair*ild ,bros4 & ,fo/] = comm5t 9 accordance ) ! ,c\ncil's usual proc$ure4 ,! foll[+ reply 0 receiv$3 ,! long e/abli%$ cu/om ( ! use ( mixtures ( rem$ial ag5ts re/s ^u consid]ations well kn[n & g5]ally accept$4 ,?is is equally true ( comb9ations ( drugs ( simil> & dissimil> prop]ties4 ,! drugs ( ^! comb9ations1 especially ^? ( m>k$ !rapeutic action1 are well kn[n & us$ by !mselves :5 indicat$4 ,9 fact1 dissimil>ity ( action is a cause ( comb9ation1 an ess5tial ( syn]gism4 ,drugs class$ z simil> are by no means alike 9 action2 laxatives1 tonics1 c>m9atives1 diuretics are comb9$ ) di/9ct advantage1 economy ( dose1 enhanc$ effect1 pot5cy n obta9able ) ! s+le drug4 ,y\r sweep+ arbitr>y conclusions t complex mixtures ( rem$ial ag5ts are f e po9t ( view inimical to !rapeutic progress is n1 x seems to u1 su/a9$ by fact & exp]i5ce4 ,!re is !rapeutic progress 9 ! consid]ate use & obs]vation ( comb9ations z well z 9 ! use ( a s+le drug4 ,inde$1 9 ! production ( a syn!tic *emical sub/ance z a !rapeutic ag5t1 ! comb9ation ( pot5t & dissimil> elem5ts is work$ out to mitigate & correct an objectionable side effect1 & promote desirable action4 ,z = ourselves1 at ! v outset 9 our l9e ( "w we q volunt>ily decl>$ our pr9ciples & our int5tions z oppos$ to incompatible & !re=e un/able or in]t comb9ations ( ! enzymes2 & aga9/ ! 8unnecess>y multiplication ( prep>ations0--see ,fair*ild's ,h&-,book ( ! ,dige/ive ,f]m5ts4 ,is n ?is aft] all ! crux ( ! :ole matt]--does a comb9ation conta9 ! +r$i5ts /at$1 does x possess ! demon/rable prop]ties :i* are to be attribut$ to x 9 consequ5ce ( ?is composition2 & if = a c]ta9 purpose1 is x well design$ !re=8 ,c>m9zym pres5ts c]ta9 ag5ts ( well kn[n prop]ties1 n 9 ! lea/ ( incompatible or antagoni/ic action1 b inde$ especially suitable = ! p>ticul> purpose design$2 its efficacy n to be measur$ & judg$ by !ory or op9ion z to ! effici5cy ( a c]ta9 dosage ( a p>ticul> drug by itself4 ,t ! doses z conta9$ are m9imal & effective is di/9ctly advantage\s4 ,! alkal9e c>bonates are 9 ,c>m9zym 9 /at$ quantities2 ! physician adju/s ! dosage to ! individual pati5t & ) obvi\s evid5ce ( ! effici5cy ( ! adju/m5t4 ,z we und]/& x1 ! employm5t ( alkal9e c>bonates is n bas$ on purely *emic consid]ations--a def9ite kn[n quantity ( acid ( ! ga/ric juice is to be neutraliz$2 ! :ole lit]ature & practice deal+ ) ! alkal9e c>bonates %[ !m to be accr$it$ ) a mu* wid] field ( use & repute 9 ga/ro-inte/9al disord]s4 ,! pancreatic extract 9 ,c>m9zym is design$ to be diffusible 9 ! /oma*1 ! tablet is pref]able to be cru%$ 9 ! m\? be=e swall[+1 & we believe ! pancreatic extract to be an effective con/itu5t z adm9i/]$ 9 ,c>m9zym4 ,y comm5t z foll[s3 8,ipecac has a well def9$ ?\gh limit$ field ( usefulness4 ,:5 x is us$ x %\ld be giv5 ) due reg>d to ! am\nt ne$$ by ! pati5t & ! frequ5cy ( ! repetition ( ! dose40 ,?is 9 a s5se may be said ( any ( ! mo/ useful drugs1 b n 9 ! lea/ special degree does x apply to ipecac1 :i* is1 on ! contr>y1 ( q *>act]i/ic1 peculi> range ( !rapeutic prop]ties1 useful 9 v>y+ comb9ations & 9 widely v>y+ proportions & doses accord+ to ! purpose = :i* x is employ$4 ,ipecac 9 well kn[n (ficial alkal9e1 c>m9ative1 laxative prep>ations occurs 9 ! 8av]age dose0 9 ! v>y+ quantities ( #a_/ad1 #a_/aj1 #a_/h1 & #c_/af ( a gra94 ,! ipecac 9 comb9ation ) ! o!r +r$i5ts 9 ,c>m9zym is design$ = a tablet :i* %all c>ry a m9imal quantity :il/ capable ( adequate rem$ial action1 ?us admitt+ ( increase ( dosage or repetition z occasion requires4 ,! quantity ( ipecac 0 n tak5 at r&om1 b *os5 aft] long trial & consid]ation4 ,we believe t ,c>m9zym possesses c>m9ative prop]ties 9 a sup]ior degree & t1 fur!rmore1 9 consequ5ce ( its composition x directly /imulates ! gl& secretions & ?us ex]ts a b5eficial action ^u ! :ole dige/ive functions4 ,c>m9zym is = use z occasion requires1 & ?is is to be especially not$4 ,?us x is n only ( direct b5efit1 b helpful 9 promot+ sy/ematic !rapeutic measures & regim54 ,! ,c\ncil takes ! gr\nd t complex mixtures ( rem$ial ag5ts are s wrong t !re is no long] w>rant = _! admission into ,new & ,non(ficial ,rem$ies2 & t ,c>m9zym is an irrational mixture4 ,we hold t c]ta9 desirable !rapeutic prop]ties may rationally be attributable to ,c>m9zym2 & t ^! are manife/$ 9 practice4 ,dur+ ! "t s9ce ! description 0 s5t & ! receipt ( ! /atem5t ( ! action ( ! ,c\ncil1 "s t5 mon?s1 ,c>m9zym has prov$ ( con/antly increas+ s]vice4 ,! /atem5t 9 ! lett] ( ,fair*ild ,bros4 & ,fo/] 8,! long e/abli%$ cu/om ( ! use ( mixtures ( rem$ial ag5ts re/s on consid]ations well kn[n & g5]ally accept$0 might well be p>aphras$ to read3 ,! "o-"t preval5t cu/om ( us+ ill-consid]$ comb9ations ( rem$ial ag5ts has be5 ?or\ghly discr$it$ & is g5]ally ab&on$ by progressive practition]s4 ,su* argum5ts z t 8laxatives1 tonics1 c>m9atives1 diuretics are comb9$ ) di/9ct advantage0 h l$ to ! use ( irrational mixtures su* z ! comp\nd syrup ( hypophosphites & ! electu>y ( !riaca4 ,! ,c\ncil is confid5t t no "o :o has /udi$ ! causes & treatm5t ( dige/ive disord]s w f9d occasion to prescribe at "o "t all ! +r$i5ts /at$ to be conta9$ 9 ,c>m9zym1 & c]ta9ly n 9 ! fix$ proportions pres5t !re94 ,! comm5ts 9 ! ,c\ncil's report conc]n+ ipecac c]ta9ly does apply to all active !rapeutic ag5ts4 ,ipecac 0 m5tion$ 9 ! report because ! sev]al con/itu5ts ( ,c>m9zym 7 "u discussion & h5ce x 0 necess>y to po9t out ! futility ( ! small dosage ( ipecac 9 ?is mixture4 ,! ann\ncem5t t 8,c>m9zym has prov$ ( con/antly increas+ s]vice0 is n conv9c+4 ,! ,c\ncil does n "k ( a s+le cl9ical /udy ( ! action ( ,c>m9zym "u conditions :i* w\ld h af=d$ satisfactory evid5ce ( its !rapeutic value4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,sept4 #bh1 #aiah47 ,,phillips' ,,phospho-,,muriate ,,( ,,qu99e ,,comp4 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! foll[+ report on ,phillips' ,phospho-,muriate ( ,qu99e ,comp4 has be5 adopt$ by ! ,c\ncil & au?oriz$ = publication4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,phillips' ,phospho-,muriate ( ,qu99e ,comp4#abe is sold by ! ,*>les ,h4 ,phillips ,*emical ,co41 ,new ,york4 ,accord+ to ! publi%$ =mula1 ea* fluidram conta9s3 ,phosphoric ,acid #b m9ims ,potassium ,phosphate ,magnesium ,phosphate ,calcium ,phosphate #b-a_/d gra9s ,f]ric ,phosphate ,qu99 ,muriate 7equal to ne>ly #a_/b gr4 ,bi-,sulph47 #a_/d gra9 ,/ry*n9 #a_/abj gra9 ,flavor+1 ,glyc]9 & ,syrup1 q4 s4 #abe ,! evolution ( 8,phillips' ,phospho-,muriate ( ,qu99e ,comp40 f 8,phillips' ,:eat ,phosphates0 may be int]e/+4 ,e "o kn[s t !rapeutics t5ds to fa%ions1 & 8,phillips' ,:eat ,phosphates0 appe>s to h _h its inception z ! result ( ! obs]vation t sup]-ref9$ :ite fl\r conta9s less phosphates ?an ! correspond+ am\nt ( :eat4 ,x 0 assum$ t su* fl\r mu/ be defici5t 9 an ess5tial con/itu5t1 & ! ,:eat ,phosphates prep>ation 0 app>5tly design$ to fill ! want4 ,x 0 exploit$ = ! relief ( num]\s conditions t 7 suppos$1 )\t satisfactory evid5ce1 to result f ?is defici5cy4 ,:5 iron1 qu99 & /ry*n9 mixtures became ! vogue a qu>t] ( a c5tury ago1 x 0 only natural to ride on ! wave ( popul>ity & ! already widely adv]tis$ 8,:eat ,phosphates0 0 fur!r enhanc$--comm]cially--by ! addition ( ! iron1 qu99 & /ry*n91 ! am\nt ( alkaloid add$ be+ practically negligible4 ,^? :o are n famili> ) ! v>i\s phases ( ! phosphorus1 phosphoric acid1 lactophosphate1 leci?91 nucle9 & glyc]ophosphate propag&a are ref]r$ to a report ( ! ,c\ncil on ,ph>macy & ,*emi/ry 9 ,! ,j\rnal ,a4 ,m4 ,a41 ,sept4 #cj1 #aiaf1 p4 #ajcc4 ,"s typical claims made = ! prep>ation are3 8,) m>k$ b5eficial action ^u ! n]v\s sy/em4 ,to be reli$ on :]e a defici5cy ( ! phosphates is evid5t40 8444 brace ^? tir$ n]ves & aid t worn /oma* ) ,phillips' ,phospho-,muriate ( ,qu99e40 8,! ma9t5ance ( a satisfactory blood pressure level free f int]vals ( depression may be accompli%$ by ! use ( ,phillips' ,phospho-,muriate ( ,qu99e ,comp\nd 9 appropriate doses40 8,! quantities ( qu99 & /ry*n9 9 ?is prep>ation are s well balanc$ t !y relieve ! depression & fatigue f m5tal or physical ex]tion1 )\t ! necessity ( rec\rse to alcoholic /imulation40 8,! o!r +r$i5ts ( ,phillips' ,phospho-,muriate ( ,qu99e--phosphoric acid1 & ! phosphates ( pota%1 magnesia1 lime1 & iron--are ! mo/ rational z well z conv5i5t means ( adm9i/]+ ^! tissue rem$ies1 & ( introduc+ phosphorus--! vitaliz+ con/itu5t ( ! n]v\s sy/em--into ! organism40 ,! action ( su* a mixture z a :ole is practically t ( ! sum ( ! actions ( its con/itu5ts4 ,! !rapeutic action ( /ry*n9 & qu99 are describ$ 9 e text-book ( !rapeutics1 b x is necess>y to di/+ui% c>efully betwe5 ! v>i\s conditions 9 :i* ^! alkaloids h be5 us$ )\t discrim9ation1 & ^? conditions 9 :i* !y h be5 prov$ to be ( value4 ,:ile bo? h be5 widely us$ 9 a great v>iety ( conditions1 nei!r is ( prov$ value 9 m ?an a di/9ctly limit$ range ( diseases4 ,! manufactur]s ( ,phillips' ,phospho-,muriate ( ,qu99e ,comp4 seem to appeal to ! less discrim9at+ :o use ^! alkaloids )\t any def9ite conception ( exactly :at !y seek to accompli% ) !m4 ,qu991 al?\gh us$ by ! uncritical 9 a ho/ ( diseases1 has a def9ite field ( usefulness 9 ! treatm5t ( mal>ia1 bo? prophylactic & curative1 b ! requir$ dose 9 ! treatm5t ( mal>ia is _m times l>g] ?an t recomm5d$ 9 ! ,phillips' prep>ation4 ,! claim t ! 8/ry*n9 & qu99 9 ?is prep>ation are s well balanc$ t !y produce a mild1 buoyant effect1 s advantage\s1 in/ead ( alcoholic /imulation1 to relieve depression & fatigue f m5tal or physical ex]tion0 is nons5sical1 if1 inde$1 x is n m5daci\s bald]da%4 ,calcium & potassium h important functions 9 ! body1 b any defici5cy t may arise is usually attributable to an inability ( ! body to utilize t :i* is suppli$1 = !re is seldom any defici5cy ( ^! salts 9 ! food1 & :5 !y are ne$$ !y are be/ suppli$ z simple solutions ( ! salts 9 appropriate doses )\t all ( ! o!r con/itu5ts ( ,phillips' ,phospho-,muriate ( ,qu99e ,comp4 ,phosphoric acid ex]ts practically ! same actions z o!r m9]al acids1 hydro*loric be+ usually pref]r$ = int]nal adm9i/ration 9 c]ta9 =ms ( indige/ion1 aside f :i* !y are seldom us$ z su*4 ,9 ! m rec5t lit]ature = ,phillips' ,phospho-,muriate ( ,qu99e ,comp41 we f9d ! attempt to utilize ! well kn[n craze ab\t phosphorus1 :i* has be5 ?r\gh s _m phases1 e "o ( :i* has _h its day & has be5 disc>d$4 ,! phosphoric acid & phosphates pres5t 9 ,phillips' ,phospho-,muriate ( ,qu99e are ( no m value 9 n]v\s diseases ?an is simple sodium phosphate :i* does n require ! addition ( a ho/ ( o!r +r$i5ts = its action4 ,z a matt] ( fact1 ! phosphates ( calcium & potassium pres5t 9 a dose ( ,phillips' ,phospho-,muriate ( ,qu99e are probably devoid ( appreciable effect 9 practically all conditions4 ,to pret5d t "o :o suff]s f physical & n]v\s exhau/ion c be mat]ially b5efit$ by ?is mixture is %e] nons5se & is unwor?y ( a mom5t's consid]ation by a cl9ician :o is call$ on to treat su* pati5ts4 ,iron is useful 9 anemia1 z e "o kn[s4 ,iron has practically no o!r field ( usefulness 9 !rapeutics4 ,:5 x is indicat$ x %\ld be adm9i/]$ 9 a simple =m1 su* z ! pill ( f]r\s c>bonate1 = example1 & n 9 a 8%otgun0 mixture t is q z likely to d h>m z good4 ,! claim t a satisfactory level ( blood pressure c be ma9ta9$ by ,phillips' ,phospho-,muriate ( ,qu99e is m5tion$ only to condemn z ! limit ( impud5t !rapeutic claims4 ,x is an insult to ! intellig5ce ( any practition] to pret5d t any kn[n ag5t or comb9ation ( rem$ial ag5ts c ma9ta9 a uni=m blood pressure 9 any "o ( innum]able conditions4 ,9 %ort1 ,phillips' ,phospho-,muriate ( ,qu99e ,comp4 is a complex & irrational mixture exploit$ by means ( unw>rant$ claims4 ,x is a survival ( ! old days ( !rapeutic *aos :5 impossible & fanta/ic *emical =mulas 7 gravely publi%$ & z solemnly accept$ )\t "q1 & also )\t ! slighte/ und]/&+ on ! "p ( _m2 :5 ! mo/ em95t ( practition]s did n hesitate to give gl[+ te/imonials = li?ia wat]s t conta9$ no m li?ium ?an ord9>y riv] wat]2 :5 no !rapeutic claim 0 too prepo/]\s to receive acceptance1 no !ory too nons5sical to ju/ify ! use ( all mann] ( claptrap mixtures = all mann] ( conditions4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,oct4 #ai1 #aiah47 ,b4 ,,iod9e ,,& ,b4 ,,oleum ,,iod9e ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has au?oriz$ publication ( ! foll[+ report on 8,b4 ,iod9e0 & 8,b4 ,oleum ,iod9e10 toge!r ) ! reply submitt$ by ! manufactur] & a discussion !reon by ! ref]ee 9 *>ge ( ! prep>ations4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,specim5s ( ,b4 ,iod9e & ,b4 ,oleum ,iod9e 7,b4 ,iod9e ,*emical ,company7 & an adv]tis+ pamphlet 7 s5t to ! ,c\ncil by ,john ,bohl&]1 ,a4,m41 ,m4,d41 ) ! decl>ation3 8,well kn[+ ! value ( ,iod9 9 surgical op]ations & dress+s1 prompt$ me = ! b5efit ( my fell[ physicians z well z myself1 & = ,humanity's sake1 to make ,iod9 my ma/]-piece 9 *emi/ry4 8,aft] sev]al ye>s ( dilig5t "w 9 my private laboratory ,i succe$$ 9 discov]+ a new product ( ,iod9--,nitrog51 hydrate ( ,iod940 ,:ile 8,b4 ,iod9e0 is said to be nitrog5 hydrate ( iod9 & 8,b4 ,oleum ,iod9e0 a #e p] c5t4 solution !re(1 ! exam9ation made by ,pr(4 ,a4 ,h4 ,cl>k ( ! ,univ]sity ( ,ill9ois1 ,s*ool ( ,ph>macy 7work+ 9 ! ,a4 ,m4 ,a4 ,*emical ,laboratory71 indicates t ! fir/ is a simple mixture ( iod9 & ammonium iodid1 & ! second a solution ( iod9 9 liquid petrolatum4 ,! ,c\ncil adopt$ ! report ( ! ,a4 ,m4 ,a4 ,*emical ,laboratory 7:i* appe>s bel[7 & decl>$ ,b4 ,iod9e & ,b4 ,oleum ,iod9e inadmissible to ,new & ,non(ficial ,rem$ies because3 #a4 ,! composition is incorrectly decl>$4 ,b4 ,iod9e is n a newly discov]$ iod9 comp\nd1 8,nitrog5 ,hydrate ( ,iod9e10 b a mixture ( iod9 & ammonium iodid4 ,b4 ,oleum ,iod9e is n a #e p] c5t4 solution ( ,b4 ,iod9e z sugge/$ by ! /atem5t on ! label & 9 ! adv]tis+1 b a solution ( iod9 9 liquid petrolatum conta9+ ab\t #j4he p] c5t4 ( iod94 #b4 ,s9ce ,b4 ,iod9e is a mixture ( ,iod9 & ammonium iodid1 its solution 9 wat] w h ! prop]ties ( o!r solutions ( iod9 made by ! aid ( iodid1 su* z a dilution ( t9cture ( iod9 or ( comp\nd solution ( iod9 7,lugol's solution74 ,h5ce1 ! !rapeutic claim t ,b4 ,iod9e 8be+ ( a colloidal nature has ! advantage ( be+ m readily absorb$ & tak5 up by all cellul> /ructure1 ?us gett+ a p]fect cellul> m$ication ( ,iod9e10 is unw>rant$4 #c4 ,! names 8,b4 ,iod9e0 & 8,b4 ,oleum ,iod9e0 are n descriptive ( ! ph>maceutical mixtures to :i* !y are appli$4 #d4 ,b4 ,iod9e & ,b4 ,oleum ,iod9e are uness5tial modifications ( e/abli%$ articles4 ,b4 ,iod9e has no advantage ov] t9cture ( iod9 or comp\nd solution ( iod94 7,z m conv5i5t ( transportation1 ! ,m$ical ,dep>tm5t ( ! ,u4 ,s4 ,army supplies its field hospitals ) a mixture ( iod9 & iodid ready = solution 9 wat]1 ei!r 9 tablet =m or 9 p[d]$ =m 9 tubes47 ,solutions ( iod9 9 liquid petrolatum may be readily prep>$ 7,reports ,c\ncil ,ph>m4 & ,*em41 #aiag1 p4 #hh74 ,contribution f ! ,a4 ,m4 ,a4 ,*emical ,laboratory ,b4 ,,iod9e ,,products ,a4 ,h4 ,cl>k1 ,ph4,g41 ,b4,s4 8,b4 ,iod9e0 products are m>ket$ by ! ,b4 ,iod9e ,*emical ,company1 ,c9c9nati1 ,ohio2 ,john ,bohl&]1 ,a4,m41 ,m4,d41 is said to be ! discov]]4 ,!y consi/ ( 8,b4 ,iod9e10 8,b4 ,oleum ,iod9e10 & 8,b4 ,aqua ,iod9e40 ,b4 ,iod9e & ,b4 ,oleum ,iod9e 7 submitt$ to ! ,c\ncil4 ,9 a circul> submitt$ by ! ,b4 ,iod9e ,*emical ,company1 ,b4 ,iod9e is said to be 8,nitrog5 ,hydrate ( ,iod940 ,x is claim$ t 8com+ 9 contact ) wat]1 ,h,o1 a *emical *ange takes place =m+ ,hydro ,oxid ( ,iod91 ! ,nitrog5 ( ! ,nitrog5 ,hydrate ( ,iod9 escap+1 ! balance tak+ up "o ( oxyg5 ( ! wat]4 ,its companion1 ! ,h1 escap+ at ! same "t ) ! ,nitrog5 !n comb9+ ) ! rema9d] ( ! wat] to =m ! solution ( ,hydrog5 ,oxid ( ,iod92 s y c readily see t y really h a pure wat] ( ,iod91 no?+ b ! ,h1 ! ,o & ! ,i40--7,f ! ,j\rnal ,a4 ,m4 ,a41 ,feb4 #a1 #aiai47 ,b4 ,,iod9e ,accord+ to ! circul>1 ,b4 ,iod9e is soluble 9 alcohol1 *lor(orm1 & e!r4 ,also x3 8,has odor1 ta/e1 melt+ & boil+ po9t1 same z regul> ,iod91 has a great aff9ity = wat] & w respond to all ! te/s ( ,iod94 ,appe>s 9 a ,blui% ,black ,granulat$ mass or ,p[d]4 ,:5 heat$ 9 vaporat+ di% w ?r[ (f l>ge purple volumes ( ,iod9 leav+ a slight :ite cry/all9e precipitate1 :i* on cont9u\s heat+ w entirely disappe>4 ,) c>eful manipulation y c get prismatic ne$le po9t l cry/als1 look+ l spores ( glass1 ^! dissolv+ 9 wat] w yield pure ,iod9 color+ ! wat] ,iod94 8,,ph>macologic1 ,,!rapeutical ,,& ,,physiological ,,action3 ,same z ,iod91 be+ ( a colloidal nature has ! advantage ( be+ m readily absorb$ & tak5 up by all cellul> /ructure1 ?us gett+ a p]fect cellul> m$ication ( ,iod940 ,a sample ( ,b4 ,iod9e1 m>k$ 8,nitrog5 ,hydrate ( ,iod90 0 submitt$ by ! manufactur]s & ?is sample 0 exam9$4 ,b4 ,iod9e 0 f\nd to be a granul> p[d]1 almo/ black ) a purple ca/4 ,x has an odor ( iod9 & dissolves 9 wat] readily4 ,x is also q soluble 9 alcohol1 b n entirely soluble 9 *lor(orm & e!r4 ,e!r quickly dissolves iod9 f ,b4 ,iod9e1 leav+ a residue ( a :ite granul> sub/ance4 ,*lor(orm acts ! same z e!r except t ! iod9 is dissolv$ out ) "s difficulty4 ,on heat+ ,b4 ,iod9e1 vapors ( iod9 escape4 ,if ! heat+ is done on a wat] ba?1 a residue ( a :ite granul> sub/ance1 subsequ5tly id5tifi$ z ammonium iodid1 rema9s4 ,if heat$ 9 a buns5 flame1 no residue rema9s4 ,^! te/s all indicate t iod9 is held 9 ! =m ( a simple mixture4 ,ammonia3 ,b4 ,iod9e :5 mix$ ) an excess ( sodium hydroxid & w>m$1 evolves ammonia4 ,iod9e3 #j4aefg gm4 ,b4 ,iod9e dissolv$ 9 wat] requir$ #e4hh c4c4 t5?-normal sodium ?iosulphate solution indicat+ #dh4bh p] c5t4 iod94 #j4cgba gm4 ,b4 ,iod9e requir$ #ad4ah c4c4 t5?-normal sodium ?iosulphate solution indicat+ #dh4cg p] c5t4 iod94 ,! av]age is #dh4cc p] c5t4 iod94 ,ammonium ,iodide3 #j4cdec gm4 ( ! residue aft] heat+ ,b4 ,iod9e on a wat] ba? until all iod9 _h volatiliz$ 0 dissolv$ 9 wat]1 acidulat$ ) phosphoric acid1 & hydrog5 dioxid solution add$4 ,! lib]at$ iod9 0 extract$ ) *lor(orm & titrat$ ) t5?-normal sodium ?iosulphate4 #bc4gh c4c4 7 requir$ indicat+ #j4cddg gm41 or #ii4hc p] c5t41 ammonium iodid4 ,a mixture ( #e gm4 iod9 & #e gm4 ammonium iodid has ! prop]ties ( ,b4 ,iod9e m5tion$ above4 ,! conclusion is t ,b4 ,iod9e is ess5tially a mixture ( iod9 & ammonium iodid 9 equal p>ts1 ! two sub/ances be+ f9ely p[d]$ & intimately mix$4 ,b4 ,,oleum ,,iod9e ,! foll[+ reg>d+ ,b4 ,oleum ,iod9e is quot$ f ! circul> submitt$3 8,b4 ,,oleum ,,iod9e3 ,iod9e soluble 9 m9]al oil #e & #aj = ,nasal1 ,ph>yngeal1 ,l>yngeal1 ,bron*ial1 ,rectal1 etc41 & all meucoid affections & abnormal conditions ( ! muc\s membrane40 ,a sample ( ,b4 ,oleum ,iod9e 0 submitt$ by ! manufactur] & exam9$4 ,! label on ! bottle /ates t x is #e p] c5t4 ,b4 ,oleum ,iod9e 9 m9]al oil4 ,?is sample has ! *>act]i/ics ( a solution ( iod9 9 liquid petrolatum4 ,x is oily & has ! *>act]i/ic violet color4 ,ammonia3 ,b4 ,oleum ,iod9e1 s9ce x is presum$ to be a solution ( ,b4 ,iod9e1 0 exam9$ = ammonium comp\nds4 ,a small quantity 0 mix$ ) an equal volume ( /rong sodium hydroxid solution & heat$4 ,no ammonia 0 evolv$4 ,a few cry/als ( ammonium *lorid 7 add$ to a little ( ,b4 ,oleum ,iod9e & treat$ z above4 ,ammonia 0 readily detect$4 ,iod9e3 #e4bee gm4 ,b4 ,oleum ,iod9e 0 dissolv$ 9 *lor(orm & plac$ 9 a sep>ator4 ,a solution ( potassium iodid 0 add$ & ! iod9 titrat$ ) a t5?-normal sodium ?iosulphate solution4 ,x requir$ #c4e c4c4 indicat+ #j4he p] c5t4 iod94 ,! conclusion is t ,b4 ,oleum ,iod9e is a simple solution ( iod9 9 liquid petrolatum to ! ext5t ( #j4he p] c5t4 & n #e p] c5t4 z claim$4 ,fur!rmore1 x is n a solution ( ,b4 ,iod9e s9ce no ammonium comp\nd is pres5t4 ,! prec$+ report 0 s5t to ! ,b4 ,iod9e ,*emical ,company4 ,! foll[+ reply 0 receiv$3 ,y\r lett] ( ! #ba/ in/41 receiv$ & cont5ts not$ & _c q agree ) y\r report4 ,reasons :y3 ,,nh,i1 a ,nitro ,hydrate ,iodide2 ,,nh,i1 a ,nitro ,hydrate ,iodate2 & ,,nh,i,i1 ,p] ,iodide1 a molecul> comp\nd1 :i* ,i claim1 !y all be+ ( a ,,nh gr\p1 s :at c be ! objection ( ,nitrog5 ,hydrate ( ,iod9e8 ,( c\rse :5 y\r *emi/1 ) ! aid ( heat1 drove (f all ! ,iod9e1 he naturally br\ght x back to a ,,nh,i4 ,!re's :]e he gets ! ,a4,m44 ,i claim a molecul> comp\nd4 ,! ,oil ( ,iod9e ,i s5t y by mi/ake 0 a #a p] c5t4 & n a #e p] c5t4 z m>k$4 ,i claim x is made f ! resublim$ ,iod9e 9 m9]al oil & n ! ,b4 ,iod9e4 ,i claim a #e p] c5t4 has h]et(ore nev] be5 accompli%$1 s ,i !re=e c claim some?+ new4 ,tr4 ,iod9e conta9s ,alcohol & ,pota% z a base1 ! alcohol a dehydrat] & ,pota% an es*>otic1 & all o!r soluble ,iod9es l ! t9cture h a metallic base4 ,m9e has n4 ,my iod9e is compatible almo/ ) all ! salts1 alkaloids1 tannates1 & ev5 ! metals4 ,y c't say t = ! t9cture or ! o!rs4 ,n[ :y %\ld m9e n be sup]ior to o!rs8 ,prep>ations z yet are n on ! m>ket & a few pamphlets 7 pr9t$ to meet ) ! requirem5ts ( y\r rul+s & approval & %all be correct$ if we only c agree on a prop] "n z y may sugge/4 ,y\rs v truly1 ,,! ,b4 ,,iod9e ,,*emical ,,co4 ,by ,john ,bohl&]1 ,a4,m1 ,m4,d4 ,p4,s4 ,we are s5d+ y "u sep>ate cov] ano!r sample ( ! ,oil ( ,iod9e :i* is a #e p] c5t4 solution1 & all[+ = det]ioration w te/ at lea/ f\r p] c5t4 ,! ref]ee 9 *>ge ( ! prep>ations submitt$ ! above lett] to ! ,c\ncil ) ! foll[+ comm5ts3 ,! pr9cipal /atem5ts 9 ! lett] are ess5tially errone\s or mislead+3 ,mixtures or d\ble salts ( ammonium iodid & iod9 7 n discov]$ by ,dr4 ,bohl&]1 & are no?+ new4 ,wat]y solutions ( iod9 by means ( an iodid h long be5 kn[n & us$ 9 ! =m ( ,lugol's solution4 ,!re is no evid5ce t ammonium iodid is less irritat+ ?an potassium iodid4 ,on ! contr>y1 ammonium salts are g5]ally m irritat+ ?an ! correspond+ potassium salts4 ,b4 ,iod9e is n compatible ) alkaloids1 b behaves ess5tially l ,lugol's solution4 ,! ,a4 ,m4 ,a4 ,*emical ,laboratory reports t ! new sample ( ,b4 ,oleum ,iod9e conta9s only #a4b p] c5t4 ( free iod91 in/ead ( ! claim$ am\nt4 ,x is !re=e some:at weak] ?an ! iod9 petrolatum prep>$ by ! ,a4 ,m4 ,a4 ,*emical ,laboratory 7,reports ,c\ncil ,ph>m4 & ,*em41 #aiag1 p4 #hh74 ,h[ev] good ,dr4 ,bohl&]'s int5tions may be1 ! /atem5ts t he makes ab\t 8 products are mislead+ or errone\s1 & ! products are ineligible = ,n4 ,n4 ,r4--7,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiah1 p4 #dd47 ,,anti?yroid ,,prep>ations 7,,anti?yroid9-,,moebius ,,& ,,?yreoidect97 ,,omitt$ ,,f ,n4 ,n4 ,r4 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! foll[+ report expla9+ ! omission f ,new & ,non(ficial ,rem$ies ( anti?yroid prep>ations 7,anti?yroid9-,moebius & ,?yreoidect97 has be5 au?oriz$ = publication4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,new & ,non(ficial ,rem$ies1 #aiah1 conta9s a discussion ( 8anti?yroid0 prep>ation & describes two ( ^!3 ,anti?yroid9-,moebius 7,e4 ,m]ck1 ,d>m/adt1 ,g]many7 & ,?yreoidect9 7,p>ke1 ,davis ,company1 ,detroit1 ,mi*474 ,! ref]ee report$ t ^! 8anti?yroid prep>ations0 evid5tly h n realiz$ ! expectations ( _! promot]s1 & are view$ ) skepticism by practically all critical cl9icians4 ,consequ5tly1 not)/&+ ! cauti\sly word$ /atem5ts ( claims made by ! manufactur]s ( ,?yreoidect91 ! ,c\ncil approv$ ! recomm5dation t ?is prep>ation 7,?yreoidect97 be omitt$ f ,new & ,non(ficial ,rem$ies = conflict ) ,rule #f 7unw>rant$ !rapeutic claims7 & ,rule #aj 7unsci5tific & useless articles7 7,anti?yroid9-,moebius _h already be5 omitt$ because x 0 (f ! m>ket74 ,! ,c\ncil fur!r direct$ t ! g5]al article 8anti?yroid prep>ations0 be also omitt$4 ,! ,c\ncil hav+ adopt$ ! recomm5dation ( ! ref]ee1 ,?yreoidect9 is omitt$ f ,n4 ,n4 ,r41 :ile ! g5]al article appe>s bel[1 z a matt] ( record3 ,anti?yroid prep>ations are obta9$ f ! blood or milk ( animals1 aft] ! removal ( ! ?yroid gl&s4 ,! use ( ^! prep>ations is bas$ on ! !ory t ! ?yroid gl& secretes products :i* are toxic1 b :i* neutralize & are neutraliz$ by1 o!r toxic sub/ances produc$ else:]e 9 ! body4 ,removal ( ! ?yroid gl&s w\ld !n lead to ! accumulation ( ^! second toxic sub/ances z evid5c$ by ! ph5om5a ( ca*exia /rumipriva & myx$ema4 ,on ! o!r h&1 ! blood or milk ( su* animals is claim$ to be capable ( prev5t+ ! effects ( hyp]secretion ( ?yroid sub/ance1 su* z is suppos$ to occur 9 hyp]?yroidism 7,bas$['s or ,graves' disease--g5]ally call$ exoph?almic goit]74 ,^! views are l>gely hypo!tical2 attempts to give to !m a rational exp]im5tal basis h fail$1 b "s cl9ical obs]v]s report di/9ctly b5eficial results 9 ! mild] =ms ( ! diseases1 & 9 obscure n]v\s disord]s :i* are suppos$ly connect$ ) ?yroid hyp]secretion f ! adm9i/ration ( ! milk f ?yroidectomiz$ goats & also f ! use ( ! propriet>y blood prep>ations li/$ bel[4 ,! value ( ^! prep>ations is v d\btful4 ,! report$ improvem5ts may only be psy*ical or due to associat$ measures1 z is (t5 se5 9 ?is disease4 ,o!r measures ( treatm5t %\ld n be neglect$4 ,improvem5t is said to occur 9 two or ?ree weeks & to be indicat$ by an amelioration ( ! n]v\s symptoms1 tremor1 palpitation1 insomnia & excitability4 ,! adm9i/ration mu/ be long cont9u$4 ,oral & hypod]mic adm9i/ration are said to be equally effective1 b ! =m] is usually pref]r$4 ,^! prep>ations are n kn[n to be toxic1 ev5 :5 v l>ge doses are us$4--7,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiah1 p4 #ej47 ,,cephael9 ,,& ,,syrup ,,cephael9-,,lilly ,,omitt$ ,,f ,n4 ,n4 ,r4 ,,& ,,syrup ,,emetic-,,lilly ,,n ,,accept$ ,report ( ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has au?oriz$ publication ( ! foll[+ report1 :i* expla9s ! omission ( cephael9 & ,syrup ,cephael9-,lilly f ,new & ,non(ficial ,rem$ies & ! non-acceptance ( ,syrup ,emetic-,lilly4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,new & ,non(ficial ,rem$ies1 #aiah1 describes cephael9 7an alkaloid obta9$ f ipecacuanha root7 & li/s ,syrup ,cephael9-,lilly 7conta9+ #j4jhh ,gm4 cephael9 hydro*lorid p] #ajj ,cc47 z a ph>maceutical prep>ation ( x4 ,! p]iod ( acceptance = ,syrup ,cephael9-,lilly hav+ expir$1 ,eli ,lilly ,company 7 ask$ to s5d ! curr5t adv]tis+ & labels s t ! ,c\ncil might det]m9e if ! acceptance ( ?is prep>ation might be cont9u$4 ,9 reply ! firm wrote3 8,we h *ang$ ! "n ,syrup ,cephael9e to ,syrup ,emetic b ! product rema9s ! same z be=e4 ,we h no circul>s describ+ ,syrup ,emetic & c only s5d copies ( ! label40 ,! new "n 8,syrup ,emetic0 conflicts ) ! rules ( ! ,c\ncil 9 t x does n indicate ! pot5t +r$i5t ( ?is simple ph>maceutical prep>ation & 9 t x is !rapeutically sugge/ive4 ,emetics are p[]ful ag5ts1 & physicians %\ld be giv5 e opportunity ( kn[+ :at !y prescribe = ! purpose4 ,! "n be+ 9 conflict ) ,rule #h1 ! ,c\ncil vot$ to omit ,syrup ,cephael9-,lilly & n to accept ,syrup ,emetic-,lilly4 ,z ! cephael9 syrup 0 ! only prep>ation ( cephael9 admitt$ to ,new & ,non(ficial ,rem$ies1 & z ! alkaloid appe>s to h no important !rapeutic field1 ! ,c\ncil direct$ t ! description ( cephael9 also be omitt$4--7,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiah1 p4 #eb47 ,,colal9 ,,omitt$ ,,f ,n4 ,n4 ,r4 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! foll[+ report expla9+ ! omission f ,new & ,non(ficial ,rem$ies ( ,colal9 has be5 au?oriz$ = publication4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,colal9 is a bile salt prep>ation claim$ to consi/ ess5tially ( hyoglyco*olic & hyotauro*olic acids4 ,x is manufactur$ by ,rufus ,cr[ell & ,company1 ,som]ville1 ,mass41 & m>ket$ by ,s*ieffel9 & ,company1 ,new ,york4 ,an exam9ation ( ! curr5t adv]tis+ by ! ref]ee ( ! ,c\ncil 9 *>ge ( bile salt prep>ations hav+ reveal$ t claims 7 made = ,colal9 :i* 7 n 9 h>mony ) ! kn[n action ( bile prep>ations1 ,s*ieffel9 & ,company 7 in=m$ t 9 ! op9ion ( ! ref]ee ! ,colal9 circul> matt] requir$ radical revision4 ,9 ?is communication ! ref]ee's objections to ! claims 7 set =? 9 detail4 ,no reply to ?is lett] 0 receiv$1 & h5ce a copy ( ! lett] 0 s5t to ,s*ieffel9 & ,company & also to ,rufus ,cr[ell & ,company ) ! explanation t unless ! /atem5ts 9 ! ,colal9 adv]tis+ :i* ! ref]ee _h que/ion$ 7 sub/antiat$ by satisfactory evid5ce1 7 suitably revis$1 or else ! adv]tis+ matt] )drawn p5d+ revision1 ! ref]ee w\ld be oblig$ to recomm5d to ! ,c\ncil t ,colal9 be omitt$ f ,new & ,non(ficial ,rem$ies4 ,9 reply1 ,s*ieffel9 & ,company wrote t !y 7 n 8engag$ actively 9 ! introduction ( ,colal910 & agre$ to ! omission ( ,colal9 f ,n4 ,n4 ,r4 ,9 view ( ! failure to sub/antiate ! claims object$ to or an agreem5t to discont9ue !m1 ! ,c\ncil direct$ t ,colal9 & ,colal9 ,tablets be omitt$ f ,new & ,non(ficial ,rem$ies = conflict ) ,rule #f 7unw>rant$ !rapeutic claims74 ,! foll[+ are ! claims :i* ! ref]ee que/ion$3 8,colal9 embodies ! physiological function ( ! bile 9 ! inte/9al canal & also possesses prop]ties ( its own :i* are intimately connect$ ) ! function ( ! liv]40 ,! quotation implies t ,colal9 has prop]ties ess5tially diff]5t f ^? ( bile salts1 a claim :i* requires sub/antiation4 8,9 ! liv] its action seems to be t ( a g5]al /imulant ( all ! hepatic functions40 ,?is is a claim :i* requires sub/antiation4 8,by ! introduction ( ,colal9 x has !re=e become possible to actually utilize ! bile = !rapeutic purposes40 ,?is is an unw>rant$ claim1 = bile 0 us$ !rapeutically be=e ,colal9 0 introduc$4 8,z gall-/ones are *iefly compos$ ( *ole/]91 exp]im5ts 7 made to det]m9e :e!r ,colal9 w\ld dissolve ^! concretions outside ( ! body4 ,^! 7 completely successful & 7 !n foll[$ by an ext5sive s]ies ( cl9ical inve/igations on p]sons suff]+ ) *oleli?iasis1 :i* demon/rat$ t by ! adm9i/ration ( ,colal9 9 _m in/ances gall-/ones 7 evacuat$ by ! natural passages & _! fur!r =mation prev5t$ )\t resort to surgical int]v5tion40 ,?is is mislead+ 9 t ! context %[s t 8)\t surgical int]v5tion0 is meant to imply a connection betwe5 ! exp]im5ts %[+ ! solv5t p[] ( ,colal9 & ! passage ( concretions4 8444 ,colal9 n only acts z a solv5t ( *ole/]9 calculi1 b prev5ts _! fur!r =mation by remov+ ! causes ^u :i* _! developm5t dep5ds40 ,?is conveys ! impression t su* solv5t action is ex]t$ 9 ! body1 t is1 t su* concretions 9 ! gallbladd] may be dissolv$ & evacuat$ by ! use ( ,colal94 ,= ?is claim !re is no evid5ce4 8,to und]/& ! value ( ,colal9 9 inte/9al disord]s x is necess>y to be> 9 m9d ! important functions ( ! bile 9 ! inte/9al canal1 namely1 its p>ticipation 9 ! dige/ion ( fats1 its antitoxic action1 & its influ5ce ^u ! p]i/alsis40 8444 ?r\gh its antiseptic influ5ce inhibits ! production ( tox9s 9 ! inte/9es40 ,! ref]ee believes t !re is no satisfactory evid5ce t bile or bile salts c inhibit ! production ( tox9s 9 t "p ( ! inte/9e--! colon--9 :i* !y are commonly produc$4--7,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiah1 p4 #eb47 ,,=al ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! foll[+ report on ,=al1 a depilatory prep>ation1 has be5 au?oriz$ = publication by ! ,c\ncil4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,=al is sold by ! ,=al ,products ,company1 ,pittsburgh1 ,pa41 z an 8antiseptic depilatory0 ) ! special claim = its use = ! removal ( hair prior to surgical op]ation or ! dress+ ( w\nds4 ,9 addition to claims made = its hair dissolv+ action1 x is ass]t$ t1 9 remov+ ! hair f an op5 w\nd1 ,=al acts z 8an antiseptic1 :i* gu>antees aga9/ any infection40 ,x is also claim$ t1 ?\gh hair w return aft] its use1 8by prop] use x w dim9i% ! gr[? ( hair & cause ! hair to gr[ mu* sl[]1 & unlike ! razor1 ! hair w n return co>s] & ?ick]40 ,we are in=m$ by ! ,=al ,products ,company t _! prep>ation is us$ 9 _m hospitals & t 8444 "o & all are well pleas$ & a great satisfaction to d away ) ! old /yle razor 4440 ,=al is /at$ to be made accord+ to ! foll[+ =mula3 ,to manufacture sev5ty-five p\nds ( ,,=al ,/>* #ce p\nds ,b>ium-,sulphide #bj p\nds ,z9c-,oxide #aj p\nds ,calcium-,c>bonat$-,precip4 #aj p\nds ,potassium-,p]manganate #aj grams ,m5?ol-,cry/alliz$ #aj grams ,c>bolic-,acid #a_/b ounce ,lilac or ,citronel oil #c ounces ,! f\r above *emicals are go+ to a heat+ process be=e mix+ or sift+4 ,9 consid]ation ( ! prec$+1 ! ,c\ncil decl>$ ,=al inadmissible to ,new & ,non(ficial ,rem$ies = conflict ) its rules1 ?us3 #a4 ,=al is an uness5tial & irrational modification ( an e/abli%$ article4 ,:ile its manufactur] /ates t ,=al has be5 on ! m>ket = eighte5 ye>s1 ! foll[+ depilatory =mula appe>s 9 a book publi%$ ?irty-five ye>s ago 7,a practical ,treatise on ,diseases ( ! ,sk91 ,l\is ,a4 ,duhr+1 ,ed4 #c1 #ahhc7 & is to be f\nd 9 mo/ books on d]matology3 ,b>ium ,sulphid #b drams ,z9c oxid #c drams ,/>* #c drams ,p]manganates & sulphids mutually de/roy ea* o!r1 & !re=e ! addition ( ! small am\nt ( potassium p]manganate _c s]ve any useful purpose4 ,! am\nts ( ph5ol1 m5?ol & 8,lilac or ,citronel oil0 are too small to ex]cise any effect 7o!r ?an t ( a flavor7 & mu/ be consid]$ uness5tial additions4 #b4 ,=al is a ph>maceutical mixture m>ket$ "u a non-in=m+ "n4 ,:]eas x is 9 ! int]e/ ( rational m$ic9e t physicians %\ld "k ! composition ( ! prep>ations :i* !y use1 ! "n ( ?is ph>maceutical mixture fails to indicate t x conta9s ! well-kn[n & by no means always h>mless b>ium sulphid4 #c4 ,=al is sold "u exagg]at$ & unw>rant$ claims4 ,9 view ( ! small am\nt ( ph5ol pres5t & ! me?od ( us+ ! prep>ation1 ! claim t ! use ( ,=al :i*1 :5 op]at+ on op5 w\nds1 8gu>antees aga9/ any infection10 is evid5tly unw>rant$4 ,!re is no evid5ce = ! claim t ! use ( depilatories su* z ,=al ret>ds ! gr[? ( hair or r5d]s hair less co>se4 ,on ! contr>y1 ! commonly prevail+ op9ion is t depilation1 l %av+1 makes ! hair co>s]4 ,to det]m9e if 8"o & all0 ( ^? :o _h us$ ,=al 7 /ill us+ ! prep>ation1 f\r ( ! te/imonials1 appe>+ 9 an adv]tis+ pamphlet1 7 inve/igat$4 ,! ph>maci/ ( ! hospital f :i* ! fir/ ( ^! te/imonials 0 /at$ to h emanat$ repli$ t ! p]son ^: "n appe>$ 9 connection ) x _h left ! hospital ab\t t5 ye>s ago & t no depilatory prep>ation has be5 us$ 9 ?is hospital = "s "t4 ,s f> z he knew1 depilatories 7 n n[ 9 use 9 ! surgical w>ds ( ! hospital4 ,9 reg>d to ! second te/imonial1 ! ph>maci/ ( ?is hospital wrote t ! hospital _h n b\ght ! prep>ation1 b t "s ( x _h be5 obta9$ = an eld]ly deaconness1 :o _h p]sonal use = a depilatory4 ,! physician sign+ ! ?ird te/imonial repli$ t ! prep>ation 0 effectual = ! removal ( hair f ! scalp1 b t 8444 we h gott5 out ( ! habit ( us+ x40 ,9 ! case ( ! f\r? te/imonial1 its ass]t$ au?or wrote 8444 if x is appli$ 9 too l>ge a quantity or too conc5trat$1 or p]mitt$ to rema9 on too long1 x w vesicate4 ,x 0 = ?is reason *iefly t ,i discont9u$ its use4 ,x is a v bad smell+ mixture & pati5ts compla9 ( x v bitt]ly40--7,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiah1 p4 #ee47 ,,granul> ,,eff]vesc5t ,,bromide ,,& ,,acetanilid ,,comp\nd-,,mul=d ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! foll[+ report expla9+ ! omission f ,new & ,non(ficial ,rem$ies ( ,granul> ,eff]vesc5t ,bromide & ,acetanilid ,comp\nd-,mul=d has be5 au?oriz$ = publication4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,! ,c\ncil holds t complex mixtures ( rem$ial ag5ts are f e po9t ( view inimical to !rapeutic progress & !re=e to ! public welf>e4 ,!y are especially objectionable because x is impossible accurately to det]m9e ! effects :i* foll[ ! simultane\s adm9i/ration ( a numb] ( drugs hav+ dissimil> actions1 & because ! practice ( prescrib+ su* mixtures t5ds to disc\rage c>eful consid]ation ( ! special ne$s ( ! individual pati5ts )\t :i* !re c be no drug !rapy4 ,on ! contr>y1 ) ! use ( su* mixtures1 !rapeutic treatm5t becomes haphaz>d & m]e guesswork4 ,! ,c\ncil1 appreciat+ t long e/abli%$ cu/oms _c be *ang$ at once1 has appli$ ,rule #aj1 conc]n+ ! recognition ( mixtures1 ) ! greate/ l5i5cy compatible ) consi/5cy4 ,:5 !re has be5 a reasonable d\bt conc]n+ ! value ( a mixture1 x has frequ5tly direct$ t ,rule #aj %\ld n apply1 p5d+ fur!r cl9ical trial ( su* mixture4 ,9 no in/ance has subsequ5t exp]i5ce %[n t a /rict int]pretation ( ! rule w\ld h work$ h>d%ip or inju/ice4 ,! ,c\ncil feels t !re is no long] w>rant = ! admission ( complex mixtures to ,new & ,non(ficial ,rem$ies1 or = ! ret5tion ( any t h be5 admitt$1 unless def9ite evid5ce ( ! !rapeutic value ( su* comb9ations is available4 ,9 accordance ) ?is decision1 sev]al mixtures n[ describ$ 9 ,new & ,non(ficial ,rem$ies w be omitt$ at ! expiration ( ! ?ree ye> p]iod = :i* articles are accept$4 ,granul> ,eff]vesc5t ,bromide & ,acetanilid ,comp\nd-,mul=d is li/$ 9 ! ,app5dix to ,new & ,non(ficial ,rem$ies4 ,ea* #ajj ,gm4 ( ! mixture conta9s sodium bromide1 #e ,gm41 & acetanilid1 #a4e ,gm4 ,accord+ to ! label1 an am\nt conta9+ acetanilid1 #f4e gra9s1 & sodium bromide1 #bb gra9s1 is to be tak5 at a dose1 to be repeat$ 9 half an h\r if necess>y4 ,= 8*ildr510 half ?is dose is advis$4 ,! ,c\ncil has consid]$ ! available evid5ce = mixtures ( ?is sort1 & has rea*$ ! conclusion t !y are inimical to rational m$ic9e & ! public1 & !re=e 9 conflict ) ,rule #aj4 ,x holds t ! use ( mixtures ( acetanilid & sodium bromide 9 fix$ proportion is irrational & prone to induce _! indiscrim9ate use by ! public4 ,despite ! p]fectly frank decl>ation ( ! composition ( ?is mixture t is made by ! ,mul=d ,company1 ! 8directions0 w be foll[$ bl9dly & ! prep>ation w be giv5 to 8*ildr50 & 8repeat$ 9 half an h\r1 if necess>y0 9 cases 9 :i* x w\ld be held unw>rant$ to adm9i/] a dose ( #c gra9s ( acetanilid to a *ild4 ,! p]iod ( acceptance hav+ expir$ = ,granul> ,eff]vesc5t ,bromide & ,acetanilid ,comp\nd-,mul=d1 ! ,c\ncil direct$ its omission f ,new & ,non(ficial ,rem$ies = conflict ) ,rule #aj4--7;,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiah1 p4 #eh47 ,,holad9 ,,& ,,bile ,,salt ,,mixtures ,holad9 & ,bile ,salts-,fair*ild2 ,capsules ( ,bile ,salts1 ,succ9ate ( ,soda & ,ph5olph?ale9-,fair*ild2 ,capsules ( ,holad91 ,bile ,salts & ,ph5olph?ale9-,fair*ild2 ,capsules ( ,holad91 ,succ9ate ( ,soda & ,bile ,salts-,fair*ild4 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,to expla9 ! omission f ,new & ,non(ficial ,rem$ies ( c]ta9 mixtures1 ! ,c\ncil has au?oriz$ publication ( ! matt] :i* appe>s bel[4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,! ,c\ncil holds t complex mixtures ( rem$ial ag5ts are f e po9t ( view inimical to !rapeutic progress & !re=e to ! public welf>e4 ,!y are especially objectionable because x is impossible accurately to det]m9e ! effects :i* foll[ ! simultane\s adm9i/ration ( a numb] ( drugs hav+ dissimil> actions1 & because ! practice ( prescrib+ su* mixtures t5ds to disc\rage c>eful consid]ation ( ! special ne$s ( individual pati5ts )\t :i* !re c be no rational drug !rapy4 ,on ! contr>y1 ) ! use ( su* mixtures1 !rapeutic treatm5t becomes haphaz>d & m]e guesswork4 ,! ,c\ncil1 appreciat+ t long e/abli%$ cu/oms _c be *ang$ at once1 has appli$ ,rule #aj conc]n+ ! recognition ( mixtures ) ! greate/ l5i5cy compatible ) consi/5cy4 ,:5 !re has be5 a reasonable d\bt conc]n+ ! value ( a mixture x has frequ5tly direct$ t ,rule #aj %\ld n apply1 p5d+ fur!r cl9ical trial ( su* mixture4 ,9 no in/ance has subsequ5t exp]i5ce %[n t a /rict int]pretation ( ! rule w\ld h work$ h>d%ip or inju/ice4 ,! ,c\ncil feels t !re is no long] any w>rant = ! admission ( complex mixtures to ,new & ,non(ficial ,rem$ies or = ! ret5tion ( any t h be5 admitt$ unless def9ite evid5ce ( ! !rapeutic value ( su* comb9ations is available4 ,9 accordance ) ?is decision1 sev]al mixtures n[ describ$ 9 ,new & ,non(ficial ,rem$ies w be omitt$ z soon z ! ?ree ye> p]iod = :i* articles are accept$ has expir$4 ,! foll[+ prep>ations are includ$ 9 ,new & ,non(ficial ,rem$ies1 #aiah3 ,holad9 & ,bile ,salts-,fair*ild4--,a mixture ( holad91 #e p>ts1 ) bile salts-,fair*ild1 #a "p1 put up 9 #c gra9 capsules4 ,capsules ( ,bile ,salts1 ,succ9ate ( ,soda & ,ph5olph?ale94--,ea* capsule conta9s bile salts-,fair*ild1 #j4jfe ,gm4 7#a gra972 sodium succ9ate exsiccat$1 #j4b ,gm4 7#c gra9s71 & ph5olph?ale91 #j4jc ,gm4 7#a_/b gra974 ,capsules ( ,holad91 ,bile ,salts & ,ph5olph?ale94--,ea* capsule conta9s holad91 #j4ac ,gm4 7#b gra9s72 bile salts-,fair*ild1 #j4jc ,gm4 7#a_/b gra971 & ph5olph?ale91 #j4jfe ,gm4 7#a gra974 ,capsules ( ,holad91 ,succ9ate ( ,soda & ,bile ,salts4--,ea* capsule conta9s holad91 #j4bj ,gm4 7#c gra9s72 sodium succ9ate exsiccat$1 #j4bj ,gm4 7#c gra9s71 & bile salts-,fair*ild1 #j4jc ,gm4 7#a_/b gra974 ,oxbile has long be5 cr$it$ ) a *olagogue action1 :i*1 h[ev]1 has probably be5 greatly ov]e/imat$4 ,:5 pure bile salts 7 plac$ on ! m>ket "s ye>s ago1 !y & _! comp\nds 7 admitt$ to ,n4 ,n4 ,r4 ,holad9 is said to repres5t all ! con/itu5ts ( ! pancreas & to possess great pot5cy 9 respect to ! sev]al enzymes1 tryps91 amylops91 lipase1 & ! milk-curdl+ f]m5t4 ,x is n cle> :5 su* a sub/ance is indicat$ !rapeutically4 ,:ile x may be useful :5 !re is a defici5cy ( pancreat9 & ga/ric secretion1 x %\ld be us$ alone4 ,x is also q possible t bile salts may h a di/9ct1 ?\gh limit$1 field ( usefulness :5 !re is a defici5cy ( bili>y secretion2 b ! bile salts are be/ adm9i/]$ alone1 or 9 comb9ation ) su* laxatives z may be deem$ necess>y by ! physician :ile keep+ 9 m9d ! fact t diff]5t pati5ts %[ ! wide/ diff]5ce 9 _! reaction to laxatives1 mak+ comb9ations ( ^! ag5ts 9 fix$ proportion irrational4 ,ph5olph?ale9 0 popul>iz$ by no/rum mak]s2 & :ile x has "s !rapeutic value1 ?is has be5 greatly ov]e/imat$1 & x %\ld be us$ only 9 am\nts deem$ necess>y = ea* pati5t1 pref]ably alone4 ,succ9ate ( sodium 0 introduc$ z a sal9e ca?>tic1 ) ! claim t x ex]ts an antiseptic action on ! bili>y passages & gallbladd]4 ,!re is no satisfactory evid5ce to sub/antiate ?is claim4 ,! ,c\ncil ma9ta9s a lib]al attitude t[>d new prep>ations1 b x feels t x is impossible to det]m9e ! value ( ! sev]al con/itu5ts ( su* complex mixtures :5 us$ z su*2 x holds t ^! mixtures are sup]flu\s & t ! sev]al sub/ances ( :i* !y are compos$ %\ld be us$ s+ly or at mo/ ) great] att5tion to ! individual requirem5ts ( ! pati5t ?an is possible :5 ^! fix$ mixtures are prescrib$4 ,despite ! fact t ^! mixtures h be5 9 use = m ?an n9e ye>s1 !re is no satisfactory evid5ce t !y possess any advantage ov] ! simple laxatives or ! prep>ations ( bile or pancreatic extract4 ,!y are !re=e held to be 9 conflict ) ,rule #aj1 & ! ,c\ncil has direct$ t !y be n includ$ 9 ,n4 ,n4 ,r4 aft] ,dec4 #ca1 #aiah4 ,hav+ adopt$ ! prec$+ report1 ! ,c\ncil1 9 accordance ) its regul> proc$ure1 submitt$ ?is to ,fair*ild ,bros4 & ,fo/] = comm5t4 ,! foll[+ reply 0 receiv$3 ,we are entirely at v>iance ) y 9 ! arbitr>y conclusion express$ conc]n+ ! inimical influ5ce ( mixtures on !rapeutic progress1 ! practice ( m$ic9e & ! public welf>e4 ,if ! comb9ations ( ,holad9 & ,bile ,salts1 etc41 9 capsules1 7 ev] prop]ly )9 ! scope ( ,new & ,non(ficial ,rem$ies1 !y %\ld be reta9$4 ,if1 h[ev]1 complex mixtures are to be held z1 a priori1 unwor?y ( consid]ation1 ! rejection ( all w\ld naturally be a logical proce$+4 ,we believe t ! p>ticul> comb9ation ( ,holad9 & ,bile ,salts etc41 h be5 cle>ly 9 ! l9e ( !rapeutic progress--a natural evolution1 improvem5t & developm5t4 ,= _m ye>s comb9ations ( pancreatic extract & ox gall _h naturally sugge/$ !mselves4 ,:5 we realiz$ ! fact t ! bile salts 7 q cle>ly ! active pr9ciples ( ! bile1 & t !y mu/ necess>ily exi/ 9 greatly v>y+ p]c5tages 9 ! (ficial inspissat$ or ox gall1 & also because ^! ox gall products ( ph>macy 7 ( extremely v>y+ d5sity1 ev5 f t ( treacle to res9--& ( o!r objectionable "*1 we und]took to prep>e bile salts4 ,^! comb9ations are n[ fur!r ju/ifi$ 9 view ( physiological consid]ations1 ! simultane\s secretion ( ! pancreas & bile1 & ! /ate ( our k ( ! function ( bile salts1 & z co-f]m5ts1 promot+ & supplem5t+ ! pancreas enzymes4 ,! "q sugge/$ z to :e!r ! *olagogic action ( ox gall 7& bile salts7 has be5 ov]e/imat$ seems to u no cle> purport4 ,! bile salts are obvi\sly employ$ z ! means ( adm9i/]+ & ?us realiz+ :atev] prop]ties ?is secretion may h 9 m$ic9e1 ( :i* ! *olagogic action is by no means ! only consid]ation4 ,z = ph5olph?ale91 :i* is cr$it$ ) purely laxative prop]ties1 we are at a loss to see any be>+ 9 ! rem>k t ph5olph?ale9 0 popul>iz$ by no/rum mak]s4 ,we _c see t ! physician's or *emi/'s e/imate ( ph5olph?ale91 its prop]ties & uses1 c be 9 ! lea/ degree influ5c$ "o way or ! o!r by ! /atem5t t 8ph5olph?ale9 has be5 popul>iz$ by no/rum mak]s40 ,! ph5olph?ale9 & succ9ate ( soda comb9ations 7 orig9ally bo? prescrib$1 & we h simply plac$ !m at ! s]vice ( ! physician )\t o!r exploitation ( !m ?an t design$ to call att5tion to _! use 9 ! conditions indicat$4 ,^! comb9ations are (f]$ 9 a =m :i* may be adm9i/]$ by ! m\? ) ! be/ promise ( introduc+ ! sub/ance m directly 9 ! inte/9al tract dur+ ! dige/ion p]iod or at su* int]val aft] or prior to1 ! dige/ion p]iod1 z w\ld be/1 9 ! judgm5t ( ! physician1 meet ! indications4 ,^! p>ticul> comb9ations are especially desirable 9 ^! 8fix$ =ms0 s9ce !y are /able & reliable res\rces at ! comm& ( ! physicians1 ! enzymes reta9+ _! /ability & pot5cy )\t mat]ial det]ioration = _m ye>s1 & !y naturally possess ! advantages :i* are obvi\sly due to ! "* ( ! p>ticul> pancreas & bile products us$ 9 ! comb9ations4 ,fur!rmore1 ! hygroscopic & soluble organic sub/ances 9 admixture _c extemporane\sly be s prep>$ 9 seal$ capsules z to be readily available "u ! practical requirem5ts ( prescrib+ & disp5s+4 ,& we d n believe t ^? :o practice m$ic9e w be 9 accord ) y\r view t ! pancreas sub/ance %\ld necess>ily be adm9i/]$ alone1 or ! bile sub/ance alone4 ,x n[ appe>s t ^! comb9ations are to be dropp$ f ,new & ,non(ficial ,rem$ies 9 consequ5ce ( ! view1 s /at$1 t 9 cl9ical exp]i5ce 8= m ?an n9e ye>s !re is no satisfactory evid5ce t !y possess any advantage ov] ! simple laxatives or prep>ations ( bile or pancreatic extract40 ,9 reply to ?is we w\ld simply make ! foll[+ comm5t3 ,dur+ ^! 8n9e ye>s0 ^! comb9ations h inevitably be5 put to an in=m+ cl9ical trial1 because ( ! fact t !y h be5 employ$ ) success 9 disord]s ( ! pancreas & bile functions & (t5 9 *ronic & s]i\s cases :]e ! cl9ical conditions 7 obvi\s & unmi/akable4 ,! reports ( ^! cases come to u f physicians widely sep>at$ & ea* ( 8 own indep5d5t initiative4 ,x w\ld seem gratuit\s1 to say ! lea/1 to /ate t ! obs]v]s are 8dis9t]e/$10 s9ce x is q cle> t !re is no o!r int]e/ ?an t ( ! practition] & 8 pati5t4 ,x is n a case ( a new drug or comb9ations ( new rem$ies1 b simply res\rces :i*1 ^u well gr\nd$ reasons1 bo? f a !oretical & mat]ial /&po9t1 ju/ify cl9ical trial1 & ) results :i* w\ld seem f any ord9>y human /&po9t to be satisfactory cl9ical evid5ce4 ,z to ! int]pretation ( compet5t cl9ical evid5ce by ! ,c\ncil1 we w\ld1 9 view ( ! circum/ances & )\t comm5t1 ask to embody 9 ?is text ?is rule3 8,cl9ical ,evid5ce40--8,to be acceptable1 ! cl9ical evid5ce mu/ (f] objective data ) su* citation ( au?ority z w enable ! ,c\ncil to confirm ! facts & e/abli% ! sci5tific value ( ! conclusions drawn4 ,cl9ical data are wor?less :5 ! au?or is n cit$4 ,! facts on :i* claims ) reg>d to ! value ( a rem$y are bas$ mu/ h be5 r5d]$ accessible = inve/igation & confirmation by dis9t]e/$ obs]v]s1 ei!r ?r\gh publication or ?r\gh ! records ( a hospital or o!r in/itution40 ,to discr$it ^! comb9ations w\ld seem to u n only unju/ifi$1 b /]ile ( any real advancem5t 9 m$ic9e1 or ( any?+ 9 ! way ( helpfulness to ! pati5t 9 ! class ( cases 9 :i* ^! products h be5 resort$ to ) b5efit2 ?is on no o!r gr\nd really ?an ! op9ion 8t !y h no advantage ov] ! simple prep>ations !mselves40 ,naturally we %all cont9ue to prep>e ^! products & %all cont9ue to take su* action z we deem be/ to br+ !m to ! att5tion ( ! physician1 = ! conduct ( our bus9ess mu/ rema9 9 ! h&s ( ^? :o are p]sonally responsible = x4 ,& x is n[ =ty ye>s s9ce we took up ?is l9e ( "w & ) ! decl>$ int5tion ( devot+ ourselves to ! appli$ sci5ce ( ! dige/ive f]m5ts & 8to _! developm5t & practical application 9 e useful purpose 9 m$ic9e40 ,we h be5 consi/5tly 9 sympa?y ) ! fundam5tal purpose ( ! ,c\ncil1 :i* mu/ fir/ re/ ^u fact z to ! "* ( ! products (f]$ z m$ic9al ag5ts4 ,! weight ( evid5ce ju/ifies ! position t ^! p>ticul> products rationally %\ld be1 & z a matt] ( fact are1 ( important special s]vice 9 ! utilization ( ^! organic secretions 9 m$ic9e4 ,z expla9$ 9 ! prec$+ report1 ! ,c\ncil holds t complex mixtures ( rem$ial ag5ts are f e po9t ( view inimical to !rapeutic progress & !re=e to ! public welf>e4 ,!y are especially objectionable because x is impossible to det]m9e accurately ! effects :i* foll[ ! simultane\s adm9i/ration ( a numb] ( drugs hav+ dissimil> actions1 & because su* a practice t5ds /rongly to disc\rage c>eful consid]ation ( ! special ne$s ( individual pati5ts )\t :i* !re c be no !rapeutic progress4 ,on ! contr>y1 ) _! use1 !rapeutic treatm5t becomes haphaz>d & m]e guesswork4 ,! dismissal ( ! holad9 & bile salts mixtures does n involve ! "q ( ! usefulness ( holad9 or ( bile salts alone2 on ! contr>y1 ! possible usefulness ( ^! prep>ations is admitt$ 9 ! report4 ,x is ! comb9ation ( holad91 bile salts1 sodium succ9ate & ph5olph?ale9 to :i* objection is made4 ,! /atem5t ( ,fair*ild ,bros4 & ,fo/] t 8^! comb9ations are n[ fur!r ju/ifi$ 9 view ( physiological consid]ations0 is some:at mislead+4 ,x is true t bile & ! pancreatic secretion coop]ate 9 inte/9al dige/ion1 b !re is no evid5ce t 9 e case 9 :i* !re is a defici5cy ( "o ( ^! secretions !re is also a defici5cy ( ! o!r1 & x is an axiom ( sci5tific !rapeutics t no drug or rem$ial ag5t %\ld be adm9i/]$ except to fill a def9ite want4 ,o!rwise ! practice ( !rapeutics becomes m]e empiricism4 ,! prop]ties ( ph5olph?ale9 are n 9 ! lea/ influ5c$ by ! mann] ( its introduction1 z ,messrs4 ,fair*ild ,bros4 & ,fo/] emphasize2 b ! important fact 9 ?is connection is t ! popul> conception ( _! actions is greatly influ5c$ by ! mode ( introduction1 & ph5olph?ale9 has be5 widely adv]tis$ 9 a v>iety ( conditions1 s t ! popul> notion conc]n+ x is n t ( sci5tific !rapeutics4 ,9 %ort1 ! entire argum5t ( ,messrs4 ,fair*ild ,bros4 & ,fo/] conc]n+ ! exploitation ( ^! prep>ations may be summ$ up by say+ t !y h be5 us$ by cl9icians :o believe t good results h foll[$ _! use1 & t ! firm w !re=e cont9ue to supply ! dem&4 ,! t5d5cy ( "s to use any?+ br\ght to _! notice1 & ! read9ess ( manufactur]s to m>ket any?+ t physicians w use1 pres5ts ! greate/ ob/acle to !rapeutic progress4 ,!re 0 nev] a no/rum s irrational or wor?less t hone/ b undiscrim9at+ cl9icians c\ld n be f\nd :o report$ wond]ful results f its use4 ,accord+ to ,fair*ild ,bros4 & ,fo/]1 ^! holad9 & bile salts mixtures h be5 9 use = "s n9e ye>s4 ,yet ! ,c\ncil is n aw>e ( any inve/igation ( _! m]its t meets ! requirem5ts ( sci5tific rese>*4 ,! ,c\ncil is n acqua9t$ ) a s+le cl9ical inve/igation ( _! action "u conditions :i* af=d satisfactory evid5ce ( _! !rapeutic value4 ,x is obvi\sly :olly insuffici5t = a cl9ician to report t ! use ( a mixture 0 foll[$ by good results4 ,! fallacy ( su* argum5ts 0 demon/rat$ long ago4 ,he mu/ make a comp>ison ( ! results obta9$ ) ! rem$ial ag5t ) ^? obta9$ 9 z ne>ly simil> conditions z possible except = ! use ( ! ag5t4 ,we are n aw>e t any su* /udy ( ! mixtures 9 "q has be5 made4 ,x is 9 ! la/ degree irrational to hold t because bile salts are ! active con/itu5ts ( bile1 !re=e su* complex mixtures z ^! are necess>y4--7,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiah1 p4 #ei7 ,,liquor ,,santaiva1 ,s4 ,d41 ,,omitt$ ,,f ,n4 ,n4 ,r4 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! foll[+ report expla9+ ! omission f ,new & ,non(ficial ,rem$ies ( ,liquor ,santaiva1 ,s4 ,d41 has be5 au?oriz$ = publication4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,s f> ! ,c\ncil has appli$ ,rule #aj conc]n+ ! recognition ( mixtures ) ! greate/ l5i5cy compatible ) consi/5cy4 ,:5 !re has be5 a reasonable d\bt conc]n+ ! value ( a mixture1 x has frequ5tly direct$ t ,rule #aj %\ld n apply1 p5d+ fur!r cl9ical trial ( su* mixture4 ,9 no in/ance has subsequ5t exp]i5ce %[n t a /rict int]pretation ( ! rule w\ld h work$ h>d%ip or inju/ice4 ,! ,c\ncil feels t !re is no long] any w>rant = ! admission ( complex mixtures to ,new & ,non(ficial ,rem$ies or = ! ret5tion ( any t h be5 admitt$1 unless def9ite evid5ce ( ! !rapeutic value ( su* comb9ations is available4 ,! ,c\ncil be+ engag$ 9 ! annual revision ( ,new & ,non(ficial ,rem$ies1 ! ref]ee 9 *>ge ( santal prep>ations report$ t ! ?ree ye> p]iod ( acceptance _h expir$ = ,liquor ,santaiva 7,%>p ,dohme74 ,! ref]ee held t ,liquor ,santaiva1 ,s4 ,d41 decl>$ to be a solution ( santal oil & copaiba ) aromatic oils1 9 a mixture ( alcohol & wat]1 is pla9ly 9 conflict ) ! curr5t int]pretation ( ,rule #aj1 because !re 0 no s\nd evid5ce to indicate t any useful end is ga9$ by ! simultane\s adm9i/ration ( santal oil & copaiba 9 any proportion1 & t s1 ( c\rse1 !re is no evid5ce ( ! special advantage 9 ! fix$ proportions repres5t$ by ! mixture4 ,he po9t$ out t ! =mula is ess5tially a survival ( ! discr$it$ %otgun gonorrhea mixtures & !re=e recomm5d$ t its acceptance be n cont9u$4 ,! ,c\ncil agre$ to ! recomm5dation ( ! ref]ee & direct$ t ,liquor ,santaiva1 ,s4 ,d41 be omitt$ f ,new & ,non(ficial ,rem$ies4--7,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiah1 p4 #ff7 ,,maltzyme1 ,,maltzyme ,,) ,,casc>a ,,sagrada1 ,,maltzyme ,,) ,,cod ,,liv] ,,oil1 ,,maltzyme ,,f]rat$ ,,& ,,maltzyme ,,) ,,y]ba ,,santa ,,omitt$ ,,f ,n4 ,n4 ,r4 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! foll[+ report expla9+ ! omission f ,new & ,non(ficial ,rem$ies ( ! ,maltzyme prep>ations has be5 au?oriz$ = publication4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,9 #aiaf1 ! ,c\ncil vot$ to omit ,maltzyme ) ,hypophosphites1 & ,maltzyme ) ,phosphate ( ,iron1 ,qu99e & ,/ry*n9e4 ,at t "t ! labels us$ on ! ,maltzyme prep>ations /ill 9 ,new & ,non(ficial ,rem$ies conta9$ a li/ ( ,maltzyme comb9ations :i* includ$ ^? :i* _h be5 dismiss$4 ,z ! ,c\ncil does n p]mit an accept$ article to be us$ z a means ( adv]tis+ an article n accept$1 x vot$ to cont9ue ! foll[+ prep>ations = a p]iod ( ?ree ye>s on condition t ref]5ce to ! delet$ articles be omitt$ f ! labels :5 ^? !n 9 /ock _h be5 us$ up3 ,maltzyme1 ,maltzyme ) ,casc>a ,sagrada1 ,maltzyme ) ,cod ,liv] ,oil1 ,maltzyme ,f]rat$ & ,maltzyme ) ,y]ba ,santa4 ,:ile ! ,maltzyme ,company made no def9ite agreem5t to revise its adv]tis+ propag&a 9 accordance ) ! ,c\ncil's requirem5ts1 ! ,maltzyme prep>ations 7 reta9$ 9 ! belief t 9 due "t ! requir$ revision ( ! labels w\ld be made4 ,! ,c\ncil be+ engag$ 9 prep>+ ! #aiai edition ( ,new & ,non(ficial ,rem$ies1 ! ref]ee 9 *>ge ( malt extracts report$ t ! ,maltzyme ,company _h n revis$ its labels 9 accordance ) ! /ipulation ( ! ,c\ncil4 ,! ref]ee fur!r report$ he _h become conv9c$ t ! claim t ,maltzyme is 8ri* 9 malt enzymes0 is unw>rant$ & t ! t]m 8,maltzyme0 7malt plus enzyme7 is mislead+2 ?is because ( ! recogniz$ in/ability ( malt extracts 7,j\r4 ,a4 ,m4 ,a41 ,m>* #cj1 #aiab1 p4 #ied7 & because ! ,maltzyme ,company makes no def9ite /atem5t ) reg>d to ! dia/ase 7malt enzyme7 cont5t ( its prep>ations4#abf ,= ?is reason x _h be5 ! ref]ee's int5tion to propose ! deletion ( all ,maltzyme prep>ations :5 _! p]iod ( acceptance expir$ 9 #aiai4 ,z1 h[ev]1 ! pres5t ,maltzyme prep>ations are 9 contrav5tion ) ! ,c\ncil's requirem5ts1 he recomm5d$ t ! acceptance ( ^! prep>ations be cancel$ n[4 #abf ,manufactur]s are w>n$ by ! ,dep>tm5t ( ,agriculture1 ?r\gh ! ,bureau ( ,*emi/ry1 t comb9ations claim+ to conta9 dige/ive enzymes mu/ be active :5 sold4 ,if prep>ations t5d to det]iorate 9 a %ort "t1 ea* lot %\ld be dat$ & n sold aft] ! p]iod :5 !y become inactive4 ,:ile e manufactur] mu/ be consid]$ innoc5t until prov$ guilty1 & ignorant until prov$ kn[+1 x is a matt] ( k t manufactur]s h m>ket$ _! v>i\s dige/ive mixtures ) full appreciation ( _! wor?lessness4--7,j\r4 ,a4 ,m4 ,a41 ,dec4 #ai1 #aiad1 p4 #bbcd47 ,! ,c\ncil agre$ to ! recomm5dation ( ! ref]ee & direct$ t ,maltzyme1 ,maltzyme ) ,casc>a ,sagrada1 ,maltzyme ) ,cod ,liv] ,oil1 ,maltzyme ,f]rat$1 & ,maltzyme ) ,y]ba ,santa be omitt$ f ,n4 ,n4 ,r4--7,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiah1 p4 #fg7 ,,me?a=m ,,omitt$ ,,f ,n4 ,n4 ,r4 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! foll[+ report expla9+ ! omission f ,new & ,non(ficial ,rem$ies ( ,me?a=m has be5 au?oriz$ = publication4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,me?a=m is ! propriet>y "n appli$ by ,f4 ,/e>ns ,co4 to *lorbutanol4 ,be+ engag$ 9 ! annual revision ( ,new & ,non(ficial ,rem$ies1 & ! t]m ( acceptance = ,me?a=m hav+ expir$1 a trade package 0 pur*as$ to det]m9e if ! product 0 m>ket$ 9 compliance ) ! rules ( ! ,c\ncil4 ,x 0 !n f\nd t a circul> 0 wrapp$ ) ! trade package :i* adv]tis$ ,me?a=m ,inhalant1 a prep>ation n accept$ = ,new & ,non(ficial ,rem$ies4 ,= obvi\s reasons1 ! ,c\ncil does n c\nt5ance ! use ( an accept$ article z a means ( adv]tis+ an article n accept$4 ,accord+ly ,f4 ,/e>ns ,co4 0 advis$ t ! ,c\ncil w\ld be oblig$ to )draw ! acceptance ( ,me?a=m unless ! objectionable circul> 0 omitt$ f ! ,me?a=m packages4 ,/e>ns ,co4 did n give ! reque/$ assurance1 & !re=e ! ,c\ncil direct$ t ,me?a=m be omitt$ f ,new & ,non(ficial ,rem$ies4--7,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiah1 p4 #fh7 ,,p9eal ,,gl&1 ,,r$ ,,bone-,,m>r[ ,,& ,,?ymus ,,gl& ,,& ,,_! ,,prep>ations ,,omitt$ ,,f ,n4 ,n4 ,r4 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! foll[+ report expla9+ ! omission f ,new & ,non(ficial ,rem$ies ( p9eal gl&1 r$ bone-m>r[ & ?ymus gl& & _! prep>ations has be5 au?oriz$ = publication4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,p9eal gl&1 r$ bone-m>r[ & ?ymus gl& 7 admitt$ to ,new & ,non(ficial ,rem$ies :5 ^! products gave promise ( hav+ !rapeutic value4 ,! t]m ( acceptance = ! prep>ations ( p9eal gl&1 r$ bone-m>r[ & ?ymus gl& hav+ expir$1 ! ref]ee 9 *>ge ( animal organ prep>ations recomm5d$ 9 8 report = ! annual revision ( ,n4 ,n4 ,r4 t ^! products & ! g5]al articles describ+ !m be omitt$ f ,new & ,non(ficial ,rem$ies4 ,he held t ! exp]im5tal & cl9ical exp]i5ce ) !m leads to ! conclusion t !y are )\t value4 ,9 accordance ) ! recomm5dation ( ! ref]ee1 ! ,c\ncil vot$ t ! foll[+ prep>ations be omitt$ f ,new & ,non(ficial ,rem$ies3 ,desiccat$ ,p9eal ,gl&-,arm\r2 ,p9eal ,gl& ,tablets-,arm\r2 ,extract ( ,r$ ,bone-,m>r[-,arm\r2 ,desiccat$ ,?ymus-,arm\r2 ,?ymus ,tablets-,arm\r4 ,z a matt] ( record1 ! descriptive articles = p9eal gl&1 r$ bone-m>r[ & ?ymus gl&1 :i* appe>$ 9 ,new & ,non(ficial ,rem$ies1 #aiah1 are giv5 bel[4 ,p9eal ,gl& ,! functions ( ?is gl& h n yet be5 e/abli%$ b !re is "s pa?ological & "s exp]im5tal evid5ce t !re is a relation betwe5 ! gl& & "s processes ( developm5t & gr[?2 ! nature ( ?is relation is unkn[n4 ,adiposis is a frequ5t sign ( di/urb$ p9eal function1 b obs]v]s are n agre$ :e!r to int]pret ?is z indicat+ hyp(unction or hyp]function1 or possibly a concurr5t di/urbance ( ! pituit>y4 ,9 "s in/ances intrav5\s injections ( p9eal extract h seem$ to cause a di/9ct fall 9 blood pressure4 ,x has be5 inf]r$ f obs]vations 9 cases ( p9eal tumors 9 ! "y t ! gl& 9 "y individuals furni%es a secretion :i* inhibits gr[?1 p>ticul>ly ! developm5t ( ! reproductive gl&s1 b ! results ( exp]im5tal adm9i/ration ( p9eal sub/ance orally h l$ o!r obs]v]s to inf] t ! p9eal secretion favors physical & possibly m5tal & sexual developm5t4 ,x has be5 sugge/$ t1 z all evid5ce po9ts to ! fact t ! function ( ! p9eal gl& is "o ( e>ly life1 extract ( adult p9eal gl&s might be expect$ to be in]t4 ,exp]im5t has also indicat$ great] activity 9 gl&s obta9$ f "y animals ?an 9 ^? obta9$ f old] ones4 ,! ,c\ncil has decid$ to admit prep>ations ( p9eal gl& to ,new & ,non(ficial ,rem$ies simply = exp]im5tal purposes4 ,r$ ,bone-,m>r[ ,r$ bone-m>r[ consi/s l>gely 7m ?an #ij p] c5t47 ( fat4 ,9 new-born animals a ?ird or m ( ?is fat consi/s ( leci?94 ,! m>r[ ( ! bones ( new-born animals conta9s iron 7up to #a p] c5t4 or m7 9 v>i\s =ms ( organic comb9ation4 ,bo? leci?9 & iron decrease rapidly 9 ! fir/ weeks aft] bir?4 ,! comm]cial prep>ations conta9 v v>iable am\nts ( ^! con/itu5ts4 ,actions & ,uses4--,r$ bone-m>r[ is suppos$ to /imulate ! =mation ( r$ blood corpuscles2 :atev] action x may h 9 ?is direction is probably due l>gely to ! iron & leci?9 :i* x conta9s4 ,x is said to be useful 9 simple & p]nici\s anemias4 ,?ymus ,gl& ,little is kn[n z to ! functions ( ! ?ymus1 b x is believ$ to h an important relation to gr[?4 ,!re also seems to be "s relation betwe5 ! ?ymus & ?yroid1 = ! =m] is frequ5tly abnormal 9 diseases involv+ ! latt] 7hyp]?yroidism74 ,! use ( ?ymus is purely empirical4 ,x has be5 employ$ 9 ! treatm5t ( hyp]?yroidism1 rickets1 tub]culosis1 hemophilia1 & infantile m>asmus & atrophy2 its use 9 ! latt] conditions is said to be ! mo/ promis+4 ,x is claim$ on v d\btful gr\nds to ex]t a some:at favorable effect 9 c]ta9 cases ( canc]4--7,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiah1 p4 #fi7 ,,pip]az9e ,,& ,,lycetol ,,omitt$ ,,f ,n4 ,n4 ,r4 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! foll[+ report expla9+ ! omission f ,new & ,non(ficial ,rem$ies ( ,pip]az9e & ,lycetol has be5 au?oriz$ = publication4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,pip]az9e 7die?yl5$iam5e7 & ,lycetol 7a me?yl d]ivative ( die?yl5$iam5e7 7 accept$ = ,new & ,non(ficial ,rem$ies 9 #aijf4 ,bo? ,pip]az9e & ,lycetol 7 ass]t$ to be effici5t uric acid solv5ts & efficaci\s rem$ies 9 ! treatm5t ( g\t & rheumatism4 ,^! products h be5 reta9$ until n[ because !re 0 no inve/igation :i* def9itely %[$ _! uselessness z uric acid solv5ts1 ?\gh _! use is g5]ally admitt$ to h be5 disappo9t+4 ,f an exhau/ive & critical /udy ( ! available evid5ce1 ,hanzlik 7,j\r4 ,lab4 ,cl94 ,m$41 ,febru>y1 #aiag7 conclud$ t sci5tific evid5ce1 ?\gh limit$1 & cl9ical op9ion indicate t ,pip]az9e is valueless 9 g\t & t !re is suffici5t sci5tific evid5ce to indicate ! wor?lessness ( ,lycetol4 ,! ref]ee 9 *>ge ( ,pip]az9e & ,lycetol recomm5d$ t ^! products be omitt$ f ,new & ,non(ficial ,rem$ies = ! reason t !y h be5 suffici5tly tri$ to ju/ify ! conclusion t !y are n ( value4 ,! p]iod ( acceptance hav+ expir$1 ! ,c\ncil direct$ t ,pip]az9e & ,pip]az9e ,tablets 7,! ,bay] ,company1 ,inc47 & ,lycetol 7,! ,bay] ,company1 ,inc47 be omitt$ f ,new & ,non(ficial ,rem$ies4--7,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiah1 p4 #gj47 ,,/anol9d ,,liquid ,,p>aff9 ,,omitt$ ,,f ,n4 ,n4 ,r4 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,z expla9$ 9 ! report :i* foll[s1 8,/anol9d ,liquid ,p>aff90 0 omitt$ f ,new & ,non(ficial ,rem$ies at ! reque/ ( ! proprietors4 ,ann\ncem5t ( ?is omission 0 made 9 ! preface to ,new & ,non(ficial ,rem$ies1 #aiah1 b publication ( ! ,c\ncil's report 0 po/pon$ p5d+ actual conflict ) ! rules4 ,! ,c\ncil n[ au?orizes publication ( ! report because a circul> indirectly adv]tis+ ! product to ! public 0 f\nd enclos$ ) ! trade package ( ,/anol9d ,liquid ,p>aff94 ,w4 ,a4 ,puckn]1 ,secret>y4 ,/anol9d ,liquid ,p>aff9 0 admitt$ to ,new & ,non(ficial ,rem$ies 9 #aiaf1 :5 its me?od ( m>ket+ con=m$ to ! rules ( ! ,c\ncil4 ,?is br& ( liquid petrolatum1 by action ( ! ,c\ncil1 has be5 omitt$ f ,new & ,non(ficial ,rem$ies on reque/ ( ! ,/&>d ,oil ,company ( ,indiana1 its manufactur]1 :o wrote to ! ,secret>y ( ! ,c\ncil /at+ t3 8,9 ord] t our facilities = ! manufacture ( ?is oil %all be con/antly engag$1 x w be necess>y = u to f9d sales on a l>g] scale ?an 9 ! pa/4 ,to d ?is "u our pres5t adv]tis+ & m>ket+ arrangem5t we feel w be impossible40 ,?is lett]1 9 addition1 sugge/$ 8t physicians are n prescrib+ ,/anol9d ,liquid ,p>aff9 9 any consid]able proportion ( _! ord]s0 & 8t ! situation :i* n[ confronts u w\ld n be mat]ially help$ if ,/anol9d 0 specifi$ 9 all su* prescriptions40 ,fur!r1 ! ,c\ncil is ask$ to consid] :e!r x 8might be will+ to decl>e ?is prep>ation z n a ,c\ncil product10 on ! alleg$ gr\nds t 8liquid p>aff9 is n m$ic9al 9 its action & passes ?r\gh ! dige/ive tract 9 practically unalt]$ condition40 ,! ,c\ncil holds t ,/anol9d ,liquid ,p>aff9 is a drug1 & t1 !re=e1 its direct adv]tis+ to ! public is 9 contrav5tion ( ! ,c\ncil's rules4 ,con/ipation %\ld be treat$ by diet>y & hygi5ic means4 ,evacuants are only tempor>y measures4 ,liquid petrolatum is m$ic9al2 x greatly modifies ! inte/9al flora2 x acts z a lubricant & emolli5t2 x modifies ! absorptive p[]s ( ! inte/9al muc\s membrane2 x is capable ( influ5c+ ! dige/ion ( fats4 ,9 %ort1 liquid petrolatum1 be+ a drug1 its indiscrim9ate & excessive use %\ld n be enc\rag$4--7,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiah1 p4 #gb7 ,,we/]field',s ,,digitalis ,,tablets ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has adopt$ ! foll[+ report & au?oriz$ its publication4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,we/]field's ,digitalis ,tablets 7,! ,we/]field ,ph>macal ,co41 ,dayton1 ,ohio7 are claim$ to repres5t a fat free t9cture ( digitalis & to be 8ent]ic coat$40 ,x is claim$ t because ( ?is coat+ ^! tablets pass ! /oma* un*ang$ & dissolve 9 ! inte/9e1 & t ?is obviates any possibility ( ga/ric di/urbance4 ,! circul> :i* sets =? ! ass]t$ advantages ( ! tablets /ates t digitalis conta9s a fat :i* is an irritant to ! ga/ric membrane4 ,x also conta9s ! foll[+3 8,we feel no hesitation 9 say+ t if ?is rem$y is giv5 a fair trial :]e x is prop]ly indicat$1 ! result obta9$ w be a gratify+ surprise4 8,x is a common expression f physicians :o h tri$ ?is rem$y to say1 #8,surely ,i h nev] us$ ,digitalis be=e4'0 ,if ^! quotations mean any?+1 !y imply t ^! tablets pres5t a di/9ct advance 9 digitalis !rapy4 ,!re is no w>rant = su* a claim4 ,! /atem5t ) ref]5ce to ! occurr5ce ( an oil 9 digitalis is p>tly false & p>tly mislead+4 ,t9cture ( digitalis1 :i* ! tablets are claim$ to repres5t1 is fat free2 ! fix$ oil t is pres5t 9 ! drug is n soluble 9 #gj p] c5t4 alcohol1 ! m5/ruum us$ = ! prep>ation ( ! (ficial t9cture ( digitalis4 ,fur!rmore1 a fairly l>ge am\nt ( ?is oil 7su* z is pres5t 9 #ajj !rapeutic doses ( ! drug7 is incapable ( caus+ ga/ric di/urbance4 ,ga/ric di/urbance is a side action t is insep>able f slight ov]dosage ) all true digitalis bodies & is n 9 any way due to local ga/ric action4 ,! claim t su* action is prev5t$ by ! use ( ent]ic pills or tablets is obvi\sly false & mislead+4 ,! alleg$ 8common expression f physicians :o h tri$ ?is rem$y0 does n con/itute acceptable evid5ce ( ! value ( ! prep>ation4 ,! ,c\ncil decl>$ ,we/]field's ,digitalis ,tablets inadmissible to ,new & ,non(ficial ,rem$ies because unw>rant$ !rapeutic claims are made = ?is product4 ,:5 ! prec$+ report 0 submitt$ to ! ,we/]field ,ph>macal ,co41 a reply 0 receiv$ indicat+ t ! firm did n "k t progressive manufactur]s _h discont9u$ ! claim t 8fat free0 digitalis prep>ations 7 devoid ( ga/ric effects4 ,x also submitt$ a revis$ circul>1 :i*1 h[ev]1 reit]at$ ! claim t ! tablet pres5t$ a di/9ct advance 9 digitalis !rapy 9 t x 0 8fat free10 & coat$ to prev5t dis9tegration 9 ! /oma*4 ,s9ce t9cture ( digitalis & extract ( digitalis are practically devoid ( fatty mat]ial1 & s9ce x is n[ well kn[n t ! fat does n cause ga/ric di/urbance & t !rapeutic doses ( digitalis d n ex]t a local irritant action on ! /oma*1 ! manufactur]'s product & ! claims made = x m]ely t5d to p]petuate old errors4 ,! ,c\ncil decl>$ ,we/]field's ,digitalis ,tablets inadmissible to ,new & ,non(ficial ,rem$ies on ! gr\nd t ?is pres5ts an uness5tial modification ( pills ( an (ficial sub/ance4 ,x direct$ publication ( its report ) ?is explanation4--7,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiah1 p4 #ge7 ,,x](orm-,,heyd5 ,,& ,,bismu? ,,tribromph5ate-,,m]ck ,,omitt$ ,,f ,n4 ,n4 ,r4 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has au?oriz$ publication ( ! foll[+ report on ,bismu? ,tribromph5ate-,m]ck & ,x](orm-,heyd54 ,^! two products 7 f\nd n to comply ) ! /&>ds = bismu? tribromph5ate adopt$ = ,new & ,non(ficial ,rem$ies1 & h5ce c\ld n be reta9$4 ,z ! manufactur]s ( bo? products ann\nce t ef=ts t[>d ! production ( a satisfactory product are cont9u$1 ! omission ( ! two br&s is )\t prejudice to _! reacceptance :5 a satisfactory product becomes available4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,! ref]ee 9 *>ge ( bismu? prep>ations submitt$ ! foll[+ report ( ! ,a4 ,m4 ,a4 ,*emical ,laboratory :i* %[s t ,x](orm-,heyd5 & ,bismu? ,tribromph5ate-,m]ck d n comply ) ! adopt$ /&>ds = bismu? tribromph5ate4 ,"s "t ago a reque/ 0 receiv$ f ! ,m$ical ,section ( ! ,national ,c\ncil ( ,def5se = a report on a br& ( bismu? tribromph5ate4 ,9 accordance ) ?is reque/ ! firm's product 0 exam9$1 & at ! same "t & = comp>ison1 an exam9ation 0 also made ( a specim5 ( bismu? tribromph5ate receiv$ f ,m]ck & ,company1 ,octob]1 #aiae1 & ( ano!r specim5 ( bismu? tribromph5ate 8,x](orm-,heyd50 obta9$ f ! ,*icago bran* ( ! ,heyd5 ,*emical ,works 9 ,april1 #aiah4 ,! exam9ation br\ght out t ! bismu? tribromph5ate submitt$ to ! national ,c\ncil ( ,def5se conta9$ a l>ge am\nt ( uncomb9$ tribromph5ol1 :ile ! specim5 ( ,x](orm-,heyd5 conta9$ an excessive quantity ( bismu?4 ,:5 ! latt] f9d+ 0 submitt$ to ! ,heyd5 ,*emical ,works1 ! firm /at$3 8,! product _h to be made 9 ?is c\ntry aft] importations f ,europe became impossible & ! fir/ lots 7 n fully up to ! /&>d 4440 ,! firm /at$ t x c\ld n[ furni% a product :i* x consid]$ fully equal to t :i* 0 previ\sly import$1 & (f]$ to submit 8samples ( ! new mat]ial40 ,hav+ be5 reque/$ to d s1 a specim5 ( ,x](orm-,heyd5 0 receiv$ f ! ,heyd5 ,*emical ,works1 ,new ,york4 ,?is & a second specim51 pur*as$ f a ,*icago :olesale drug h\se1 7 exam9$4 ,:]eas ! /&>ds = bismu? tribromph5ate :i* _h be5 =mulat$ by ! ,laboratory & accept$ by ! ,heyd5 ,*emical ,works requir$ t ! product %\ld conta9 f #dj to #di p] c5t4 ( bismu? & conta9 n m ?an #c4c p] c5t4 ( uncomb9$ tribromph5ol1 ! specim5 pur*as$ 9 ,*icago conta9$ #fg4g p] c5t4 ( bismu?1 :ile ! specim5 receiv$ direct f ! ,heyd5 ,*emical ,works conta9$ #bd p] c5t4 ( uncomb9$ tribromph5ol4 ,:5 ?is result 0 report$ to ! ,heyd5 ,*emical ,works1 ! firm repli$3 8,x seems t we are n yet 9 a position to supply a product t answ]s a uni=m /&>d & t we h to cont9ue our ef=ts 9 ?is direction4 8,we w take ?is matt] up ) y aga9 z soon z we h be5 successful 4440 ,at ! "t :5 ! prec$+ exam9ation 0 be+ made1 bismu? tribromph5ate-,m]ck c\ld n be obta9$ f ! ,*icago :olesale h\ses4 ,a reque/ s5t to ,m]ck & ,company = a specim5 ( ! m>ket supply br\ght ! in=mation t ! product 0 tempor>ily unavailable4 ,?\gh unable to supply ! product1 ! firm gave valuable advice = a revision ( ! some:at loosely drawn te/s = bismu? tribromph5ate 9 ,new & ,non(ficial ,rem$ies1 #aiah4 ,rec5tly 7,novemb]1 #aiah7 ,m]ck & ,company s5t a specim5 ( its product label$ 8,bismu? ,tribromph5ate-,m]ck0 8,m]ck & ,company1 ,new ,york1 ,di/ributors & ,gu>antors10 & wrote 8444 ,y w notice ?is sample con=ms 9 ne>ly all details to ! te/s we submitt$ ) our lett] ( ,june #d?4 ,we h be5 able to produce bett] goods1 b j at pres5t unsatisfactory />t+ mat]ial confronts u4 ,! sample con=ms to ,n4 ,n4 ,r41 #aiah1 b w n meet ! te/ = uncomb9$ tribromph5ol submitt$ by y 9 y\r lett] ( ,septemb] #d? 4440 ,exam9ation ( ! specim5 demon/rat$ t x 0 soluble to a consid]able ext5t 9 alcohol 7! ,n4 ,n4 ,r41 #aiah1 description provides t x %\ld be only slightly soluble 9 alcohol7 & accord+ to ! /&>ds adopt$ = ,new & ,non(ficial ,rem$ies1 #aiai1 conta9s #ah p] c5t4 uncomb9$ tribromph5ol 7m ?an five times ! p]mitt$ am\nt74 ,9 view ( ! ,laboratory's report1 ! ref]ee recomm5d$ t ! acceptance ( ,x](orm-,heyd5 & ,bismu? ,tribromph5ate-,m]ck be )drawn1 )\t prejudice to _! re9/atem5t :5 satisfactory products are aga9 (f]$ = sale4 ,! ,c\ncil adopt$ ! recomm5dation ( ! ref]ee1 & accord+ly ,x](orm-,heyd5 & ,bismu? ,tribromph5ate-,m]ck are omitt$ f ,new & ,non(ficial ,rem$ies1 #aiai4 ,:5 ! ,laboratory's f9d+s ) reg>d to ,x](orm-,heyd5 & ! action ( ! ,c\ncil delet+ ! article f ,new & ,non(ficial ,rem$ies 0 report$ to ! ,heyd5 ,*emical ,works1 ! firm express$ regret t ef=ts to produce a product equal to t =m]ly obta9$ f ,g]many _h s f> n be5 successful & ann\nc$ t x _h decid$ to )draw ,x](orm-,heyd5 f ! m>ket = ! pres5t4 ,:5 ,m]ck & ,company 0 advis$ 9 reg>d to ! report ( ! ,laboratory & ! ,c\ncil's action1 ?is firm que/ion$ ! feasibility ( produc+ a product meet+ ! ,c\ncil's /&>ds & sugge/$ t ! te/ = free tribromph5ol be revis$ to p]mit z mu* z #ae p] c5t4 ( ?is con/itu5t4 ,:5 ,m]ck & ,company 0 rem9d$ t its product1 submitt$ 9 #aiae1 ess5tially compli$ ) ! adopt$ /&>ds & t ! e/imate ( ! !rapeutic value ( bismu? tribromph5ate is bas$ on a product ess5tially free f alcohol-soluble mat]ial1 ! firm repli$3 8,z /at$ 9 our lett] ( ! #ab? in/4 we d n wi% to m>ket ! *emical unless x meets all legitimate requirem5ts ( ! physicians t use x4 ,if1 !re=e1 y\r /&>d proves to be good & x is comm]cially possible to make supplies con=m+ to x1 we %all d s4 ,we %all discont9ue ! article unless x is ( suitable quality40 --7,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiah1 p4 #gf47 ,,cream ,,( ,,mu/>d ,,refus$ ,,recognition ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,cream ( ,mu/>d1 ,! ,cream ( ,mu/>d ,co41 ,s\? ,norwalk1 ,conn41 is said to be made by mix+ #b dra*ms ( oil ( mu/>d & #b dra*ms ( oil ( turp5t9e ) "o p\nd ( :ite petrolatum4 ,accord+ to ! label x is 8= ,tonsillitis1 ,rheumatism1 ,sore ,muscles1 ,cr\p1 ,pleurisy1 ,fro/$ ,feet1 ,sore ,?roat1 ,neuralgia1 ,spra9s1 ,bron*itis1 ,heada*e1 ,*ilbla9s1 ,/iff ,neck1 ,conge/ion1 ,bruises1 ,a/hma1 ,lumbago1 ,pa9s & ,a*es1 ,colds 9 ,*e/40 ,! ,c\ncil refus$ recognition to ,cream ( ,mu/>d3 ,because x is a simple ph>maceutical mixture ( well-kn[n +r$i5ts & has no advantage ov] e/abli%$ rubefaci5ts :i* e physician kn[s h[ to prescribe & e ph>maci/ to comp\nd4 ,incid5tally1 ! "n 8,cream ( ,mu/>d0 is mislead+ & n descriptive ( ! composition ( ?is ph>maceutical ( oils ( mu/>d & turp5t9e4--7,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiah1 p4 #gi7 8,,plurigl&ul>0 ,,mixtures ,caps4 ,adr5o-,sp]m9 ,comp41 ,caps4 ,ant]o-,pituit>y ,comp41 ,caps4 ,plac5to-,mamm>y ,comp41 ,caps4 ,?yro-,ov>ian ,comp41 ,caps4 ,hepato-,spl5ic ,comp41 ,caps4 ,pancreas ,comp41 & ,caps4 ,?yroid ,comp41 ,n ,admitt$ to ,n4 ,n4 ,r4 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,aft] consid]+ ! evid5ce = ! sev]al 8plurigl&ul>0 mixtures describ$ bel[1 ! ,c\ncil decl>$ !m inadmissible to ,new & ,non(ficial ,rem$ies4 ,! ,c\ncil's action 0 communicat$ to ! manufactur]1 ,h5ry ,r4 ,h>r[]1 9 accordance ) ! usual proc$ure4 ,aft] giv+ due consid]ation to ! manufactur]'s reply ! ,c\ncil au?oriz$ publication ( ! report :i* appe>s bel[4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,) ! (f] 8to supply y ) z mu* lit]ature z may be necess>y & z little ( ! actual rem$ies z may be desir$0 if 8! prospects = ! inclusion ( ^! =mulas 9 ,n4 ,n4 ,r4 are good10 ,h5ry ,r4 ,h>r[] s5t ! ,c\ncil a booklet descriptive ( 8 prep>ations & labels = ! foll[+ mixtures3 ,caps4 ,adr5o-,sp]m9 ,comp41 ea* said to conta9 8,adr5al ,gl& 7total7 gr4 #a_/d1 ,?yroid ,gl& 7,u4 ,s4 ,p47 gr4 #a_/ab1 ,sp]m9 ,extr4 7f ,gonads71 ,bra9 & ,sp9al ,cord aa gr4 #a1 ,calc4 ,glyc]ophosphate q4 s4 ad gr4 #e40 ,caps4 ,ant]o-,pituit>y ,comp41 ea* said to conta9 8,ant]ior ,pituit>y ,body gr4 #b1 ,?ymus ,gl& gr4 #a1 ,?yroid ,gl& 7,u4 ,s4 ,p47 gr4 #a_/ab1 ,calcium-phosphorus ,comp4 q4 s4 ad gr4 #e40 ,caps4 ,plac5to-,mamm>y ,co41 ea* said to conta9 8,desiccat$ ,plac5ta gr4 #b1 ,mamm>y ,sub/ance gr4 #a-a_/b1 ,pituit>y ,body 7total7 gr4 #a_/c1 ,calcium-phosphorus ,comp4 q4 s4 ad4 gr4 #e40 ,caps4 ,?yro-,ov>ian ,comp41 ea* said to conta9 8,desic4 ,corpora ,lutea ,ov>ian ,sub/ance gr4 #b-a_/b1 ,?yroid ,gl& 7,u4 ,s4 ,p47 gr4 #a_/ab1 ,pituit>y ,gl& 7total7 gr4 #a_/h1 ,calcium-phosphorus ,comp4 q4 s4 ad gr4 #e40 ,caps4 ,hepato-,spl5ic ,comp41 ea* said to conta9 8,liv] ,p>5*yma1 ,sple5 ,sub/ance aa gr4 #b1 ,p[d4 ,bile ,salts gr4 #a_/b1 ,adr5o-,sp]m9 ,co4 7,no4 #a7 gr4 #a40 ,caps4 ,pancreas ,comp41 ea* said to conta9 8,adr5al ,gl&1 ,pituit>y ,gl& 7total7 aa gr4 #a_/b1 ,ov>ian ,sub/ance gr4 #a1 ,pancreas ,sub/ance q4 s4 ad gr4 #e40 ,caps4 ,?yroid ,comp41 ea* said to conta9 8,desic4 ,?yroid ,gl& 7,u4 ,s4 ,p47 gr4 #a_/h1 ,calcium-phosphorus ,comp4 q4 s4 ad gr4 #e40 ,! ,c\ncil decl>$ ^! prep>ations inadmissible to ,new & ,non(ficial ,rem$ies1 = reasons :i* foll[3 #a4 ,ea* ( ! mixtures conta9s "o +r$i5t or m1 :i* is nei!r recogniz$ 9 ! ,u4 ,s4 ,ph>macopeia nor admitt$ to ,new & ,non(ficial ,rem$ies1 namely3 8,sp]m9 ,extract10 8,bra910 8,sp9al ,cord10 8,desiccat$ ,plac5ta10 8,liv] ,p>5*yma10 8,sple5 ,sub/ance10 8,pancreas ,sub/ance0 & 8,calcium ,phosphorus ,comp4 7,ea* #ajj gm4 repres5ts ,magnes4 ,phos4 #a2 ,calc4 glyc]ophos4 #d2 ,potas4 bic>b4 #ae2 ,sod4 bic>b4 #bb & ,sod4 *lor4 q4 s4740 ,= obvi\s reasons ! ,c\ncil does n accept a mixture conta9+ an indef9ite +r$i5t & h5ce x w\ld be necess>y z a prelim9>y = ! consid]ation ( any "o ( ! mixtures t _! un(ficial +r$i5ts be made eligible = ,new & ,non(ficial ,rem$ies by ! submission ( evid5ce t su* +r$i5t is ( uni=m composition & t x is !rapeutically valuable :5 giv5 by m\?4 ,!re is no evid5ce t _m ( ^! organs h any value :atev] :5 adm9i/]$ by ! m\? or 9 any o!r way4 #b4 ,9 ! light ( our k ! adm9i/ration ( gl& mixtures 9 ! ho/ ( conditions enum]at$ 9 ! adv]tis+ circul> is irrational & on a p> ) ! use ( ! %otgun mixtures once 9 vogue4 ,be x a ph>maceutical mixture1 a 8mix$0 vacc9e1 or a 8plurigl&ul>0 product1 ! comb9ation ( two m$ic9al +r$i5ts 9 a mixture mu/ be consid]$ contr>y to rational !rapy unless a good reason exi/s = su* comb9ation4 ,su* mixtures are held 9 conflict ) ,rule #aj unless ! manufactur] pres5ts acceptable evid5ce = ! value ( 8 comb9ation4 ,a physician may prescribe any mixture :i* he consid]s indicat$ 9 a giv5 case1 b ! m>ket+ ( mixtures ( drugs 9 fix$ proportions is 9 mo/ in/ances irrational & a detrim5t to s\nd !rapy4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #ah1 #aiai7 ,,c]el5e ,,n ,,admitt$ ,,to ,n4 ,n4 ,r4 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has au?oriz$ publication ( ! foll[+ report decl>+ ,c]el5e inadmissible to ,new & ,non(ficial ,rem$ies4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,c]el5e1 a p>aff9 prep>ation = ! treatm5t ( burns1 0 submitt$ to ! ,c\ncil by ! ,holliday ,laboratories1 ) ! /atem5t t x 0 compos$ ( #hd p] c5t4 p>aff91 #ae p] c5t4 myricyl palmitate1 & #a p] c5t4 purifi$ elemi gum to :i* is add$ oil ( eucalyptus #b p] c5t4 & betanaph?ol #j4be p] c5t4 ,x 0 expla9$3 8,myricyl ,palmitate is a purifi$ =m ( ,beeswax1 free f all impurities1 acids1 etc41 :i* is solely manufactur$ by ?is ,company44440 ,x 0 also /at$ t on 8special ord]0 ,c]el5e has be5 made conta9+ oil ( eucalyptus & resorc91 oil ( eucalyptus & picric acid1 & picric acid alone4 ,! foll[+ report on ! prep>ation 0 pres5t$ to ! ,c\ncil by ! ref]ee to :om ,c]el5e _h be5 assign$3 ,c]el5e is ano!r comp\nd wax = ! treatm5t ( burns4 ,accord+ to ! "w ( ,sollmann 7,j4 ,a4 ,m4 ,a41 #fh3agii1 #aiag7 x is highly improbable t comp\nd mixtures h any advantage ov] simple p>aff9 ( l[ melt+ po9t4 ,c]el5e mu/ !re=e be consid]$ z an uness5tial modification ( p>aff91 & z 9 conflict ) ,rule #aj2 unless def9ite evid5ce ( sup]iority is submitt$4 ,c]el5e mixtures conta9+ m$ic9al +r$i5ts also appe> unsci5tific s9ce ! evid5ce t ! +r$i5ts d n leave ! wax has n be5 successfully contradict$4 ,f9ally1 ! claims made = ,c]el5e are r extreme1 & w\ld ne$ "s revision be=e !y c\ld be accept$4 ,! ,a4 ,m4 ,a4 ,*emical ,laboratory reports3 ,! physical prop]ties ( ,c]el5e are z foll[s3 ,melt+ po9t #ej4j ,c4 by ,u4 ,s4 ,p4 me?od4 ,ductility limit #cj4e ,c4 ,pla/icity limit #bf4d ,c4 ,n /rong at #ch ,c4 ,adh]es mod]ately well2 deta*es ) 8pull+40 ,on heat+1 readily loses eucalyptol1 & a small am\nt ( res9\s sub/ance =ms 9 ! bottom ( ! beak]4 ,if ,c]el5e is heat$ to #ade ,c4 & cool$1 ! result+ product no long] has ! prop]ties ( ! orig9al ,c]el5e4 ,x is recomm5d$ t ! prec$+ report be s5t to ! ,holliday ,laboratories1 & t unless its sup]iority ov] simple p>aff9s is demon/rat$ & ! unw>rant$ claims ab&on$1 ,c]el5e be decl>$ inadmissible to ,new & ,non(ficial ,rem$ies = conflict ) ,rules #f & #aj4 ,?is report 0 submitt$ to ! ,holliday ,laboratories ) ! in=mation t x _h be5 adopt$1 ,oct4 #c1 #aiag4 ,x 0 also expla9$ t be=e ,c]el5e c\ld be accept$1 ! un(ficial & un/&>diz$ con/itu5t 8myricyl palmitate0 w\ld h to be consid]$ & accept$ = ,new & ,non(ficial ,rem$ies s9ce1 = obvi\s reasons1 ! ,c\ncil does n accept a prep>ation :i* conta9s an un(ficial & un/&>diz$ sub/ance n 9 ,n4 ,n4 ,r4 ,! ,holliday ,laboratories ackn[l$g$ receipt ( ! ,c\ncil's report & ask$ t ! matt] be held 9 abeyance until ! reque/$ evid5ce _h be5 obta9$4 ,lat] ! ,c\ncil 0 advis$ t ! adv]tis+ circul>s = ,c]el5e _h be5 )drawn ) ! exception ( "o giv+ directions = its use4 ,five mon?s lat]1 ! firm /at$ t exp]im5ts 7 be+ made 8to det]m9e ! actual /r5g? ( ,c]el5e 9 comp>ison ) o!r p>aff9 waxes44440 ,no?+ fur!r has be5 he>d f ! ,holliday ,laboratories & no reply has be5 receiv$ to an inquiry made ,oct4 #ab1 #aiah4 ,! ,c\ncil !re=e au?orizes publication ( its report decl>+ ,c]el5e inadmissible to ,new & ,non(ficial ,rem$ies4--7,f ! ,j\rnal ,a4 ,m4 ,a41 ,feb4 #ae1 #aiai74 ,,collosol ,,coca9e ,,n ,,admitt$ ,,to ,n4 ,n4 ,r ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! report :i* appe>s bel[ 0 adopt$ by ! ,c\ncil & s5t to ! ,anglo-,fr5* ,drug ,co41 ,ltd41 ,new ,york1 = comm5t 9 ,decemb]1 #aiah4 ,no explanation has be5 receiv$ f ! manufactur]4 ,= ! in=mation ( ! pr(ession ! ,c\ncil has n[ au?oriz$ publication ( ! report4 ,w4 ,a4 ,puckn]1 ,secret>y4 8,collosol ,coca9e0 0 submitt$ to ! ,c\ncil 9 ,octob]1 #aiah1 by ! ,anglo-,fr5* ,drug ,co41 ,ltd41 ,new ,york1 "u ! claim t x 0 an 8absolute colloid0 & t x conta9$ 8#a p] c5t4 coca940 ,! label on ! submitt$ specim5 decl>es3 8,collosol ,coca9e #a-ajj0 8444 ! ,coca9e exi/s z ! pure alkaloid 9 ! ,colloidal /ate--! condition 9 :i* x is isomorphic ) ! prote9 ( ! body fluids4 ,! effect is m prolong$ ?an t ( a molecul> ,coca9e ,solution & be+ non-toxic absorption pres5ts no practical dang]40 ,! product 0 assign$ to ! ,committee on ,ph>macology = consid]ation4 ,! foll[+ report 0 submitt$ & its adoption by ! ,c\ncil recomm5d$ by ! committee3 8,collosol ,coca9e0 is said to be a colloidal =m ( coca9 & is alleg$ to possess a rem>kably l[ toxicity4 ,! subjo9$ report ( ! ,a4 ,m4 ,a4 ,*emical ,laboratory1 h[ev]1 %[s t ! prep>ation does n h ! composition claim$ = x & x is1 9 effect1 misbr&$4 ,9 fact1 ! ,engli% manufactur]s conc$e t x is n an 8absolute colloid0 & t ! decl>ation ) reg>d to ! p]c5tage ( coca9 is incorrect4 ,x is recomm5d$ t1 )\t consid]+ o!r conflicts ) ! rules ( ! ,c\ncil at ?is "t1 8,collosol ,coca9e0 be decl>$ inadmissible to ,new & ,non(ficial ,rem$ies = conflict ) ,rule #a :i* requires t ! composition ( an article mu/ be correctly decl>$4 ,! report ( ! ,a4 ,m4 ,a4 ,*emical ,laboratory is app5d$4 ,,report ,,( ,,! ,a4 ,m4 ,a4 ,,*emical ,,laboratory ,simpson1 ,hewlett & ,eyre 7,lancet1 ,april #bh1 #aiag1 p4 #ffj7 report$ 8,collosol ,coca9e0 to be mu* less toxic ?an coca94 ,^! writ]s1 h[ev]1 did n v]ify ! /atem5ts z to ! composition & 9 ! light ( subsequ5t *emical exam9ation x is n to be wond]$ at t 8,collosol ,coca9e #a4j p] c5t40 0 mu* less toxic ?an a solution conta9+ #a4j p] c5t4 ( coca9 hydro*lorid4 ,b>g]1 ,dale & ,durham report f ! ,dep>tm5t ( ,bio*emi/ry & ,ph>macology1 ,m$ical ,rese>* ,committee 7,lancet1 ,dec4 #a1 #aiag1 p4 #hbe71 t !y exam9$ 8,collosol ,coca9e0 & f\nd x to conta9 b #j4be p] c5t4 ( coca94 ,!y also f\nd t ! coca9 0 n pres5t 9 a colloidal =m4 ,discuss+ ! l[ toxicity claim$ by ! manufactur]s1 ^! inve/igators /ate3 8,9 ! samples :i* we exam9$ ! toxicity 01 inde$1 mu* l[] ?an t ( an ord9>y #a p] c5t4 solution ( a coca9 salt2 b ! local ane/hetic action 0 l[ to a correspond+ degree1 & bo? actions correspond$ satisfactorily ) ! proportion ( coca9 *emically recov]able f ! solution40 ,/r\d1 ( ! ,crookes ,laboratory 7:i* manufactures ! prep>ation71 :o app>5tly _h be5 in=m$ ( ?is "w 9 advance ( publication1 admits ! correctness ( x1 & /ates 7,briti% ,m$ical ,j\rnal1 ,nov4 #bd1 #aiah1 p4 #gaj7 t 8:il/ ! colloidal protective app>5tly absorbs a portion ( ! coca91 ! rema9d] is f\nd n to exhibit ! attributes ( a colloid14440 ,! specim5 ( 8,collosol ,coca9e0 submitt$ to ! ,c\ncil & label$ 8,collosol ,coca9e #a-ajj0 0 f\nd to conta9 at mo/ #j4d p] c5t4 coca94 ,! exam9ation 0 made 9 accordance ) ! me?od us$ by ,b>g]1 ,dale & ,durham & calculat$ z coca94 ,?is me?od1 h[ev]1 probably w\ld n di/+ui% betwe5 coca9 & basic decomposition products1 b w\ld include all z coca9 9 ! am\nt f\nd4 ,! specim5 ( 8,collosol ,coca9e0 exam9$ 0 neutral or slightly acid1 a fact :i* t5ds to confirm ! conclusion ( ! ,briti% inve/igators t 8,collosol ,coca9e0 conta9s coca9 9 noncolloidal =m & precludes an increas$ physiologic effect due to alkal9ity4 ,! ,c\ncil adopt$ bo? ! report submitt$ by ! committee & t ( ! ,a4 ,m4 ,a4 ,laboratory & decl>$ 8,collosol ,coca9e0 inadmissible to ,new & ,non(ficial ,rem$ies4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,april #ab1 #aiai47 ,,cuprase ,,n ,,admitt$ ,,to ,n4 ,n4 ,r4 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has au?oriz$ publication ( ! foll[+ report on ,cuprase1 sold by ! ,anglo-,fr5* ,drug ,co41 ,ltd4 ,! ,c\ncil's criticisms ( ! adv]tis+ claims 7 s5t to ! firm1 ,decemb]1 #aiah4 ,! firm made no reply & ess5tially ! same claims are conta9$ 9 rec5t adv]tisem5ts4 ,w4 ,a4 ,puckn]1 ,secret>y4 8,cuprase0 is n[ be+ adv]tis$ & sold 9 ! ,unit$ ,/ates by ! ,anglo-,fr5* ,drug ,co41 ,ltd41 ! firm :i* also m>kets x 9 ,engl&4 ,x is said to be 8prep>$ 9 ! ,laboratories ( ,f4 ,ducatte1 #h ,place de la ,m$ele9e1 ,p>is40 ,accord+ to an adv]tis+ circul> entitl$ 8,! ,m$ical ,treatm5t ( ,canc]0 8,cuprase0 is 8*emical colloidal copp]02 9 ano!r place x is 8a colloidal copp] hydroxid10 :i* is said to be obta9$ *emically by ! r$uction ( salts ( copp] 9 ! pres5ce ( albumosic acid4 ,a box 7price #h4ej less #aj p] c5t4 disc\nt7 ( 8,cuprase-,doctor ,gaube du ,g]s0 0 pur*as$ rec5tly f ! ,anglo-,fr5* ,drug ,co41 ,ltd4 ,x conta9$ eight ampules ea* conta9+ approximately #a #bc ( a br[ni% fluoresc5t liquid4 ,no in=mation ( composition 0 giv5 on ! box1 except ! l9e3 8,*aque amp\le conti5t3 #a #bc 4#jjaba de ,cuivre pur0 7,ea* ampule conta9s ,o4#jjaba gr4 ( pure copp]74 ,! ,a4 ,m4 ,a4 ,*emical ,laboratory reports t ! prep>ation does conta9 a small am\nt ( copp]1 ) "s prote9 mat]ial & ab\t #a p] c5t4 sodium *lorid4 ,! !rapeutic claims 9 ! adv]tis+ circul> are ^? commonly made = canc] 8cures0 & are ab\t equally conv9c+4 ,! publication ( su* /atem5ts & quotations z ! foll[+1 :i* appe> 9 a pamphlet 8,! ,m$ical ,treatm5t 9 ,canc]10 _c be too /rongly condemn$ 9 a m$icam5t t at be/ has only an exp]im5tal /atus3 8,a special prep>ation1 ,cuprase1 has be5 introduc$ into !rapeutics :i* has be5 rem>kably successful4 ,9 ! hi/ory ( ! !rapeutics ( canc]1 no?+ has be5 f\nd :i* c comp>e ) ! effects produc$ by means ( ,cuprase4 ,cl9ical facts c>ry great] weight ?an !oretical d$uctions4 ,x foll[s1 f ! cl9ical obs]vations :i* ,i h collect$1 t 9 ! l>ge majority ( cases ,cuprase effects ! dim9ution or disappe>ance ( ! pa9s1 an improvem5t 9 ! g5]al condition1 a dim9ution or arre/ ( ! neoplasms1 & f9ally 9 c]ta9 cases1 a cure has be5 effect$4 ,x %\ld be rem>k$ t all or ne>ly all ! obs]vations ref] to inop]able cases 9 :i* ! prognosis 0 unfavorable at an e>ly date4 ,x is ne$less to emphasize ! practical importance ( a prep>ation capable ( yield+ su* results1 ev5 relative1 9 ! wor/ /ages ( a disease :i* has always be5 reg>d$ z absolutely resi/+ ! action ( all int]nal rem$ies40 8,to sum up1 ,cuprase has giv5 positive results 9 ab\t #id p] c5t4 ( ! cases 9 :i* x has be5 employ$ = a suffici5tly long p]iod1 & "s brilliant results 9 ab\t #bj p] c5t4 ( ^! cases4 ,!re=e1 x may be affirm$1 t among ! int]nal rem$ies = canc]1 ,cuprase is ! "o :i* has produc$ ! mo/ successful results1 & c1 "u c]ta9 circum/ances1 compete ) surgical me?ods1 ev51 s f> z ! rapidity ( _! results are conc]n$40 8,x is indicat$3 7a7 ap>t f all op]ation1 & z a specific & curative rem$y2 7b7 be=e an op]ation1 9 ord] to give tone to ! pati5t1 mobilise ! tumor1 de/roy its tox9s2 7c7 aft] ! op]ation1 z a tonic & anti-toxic1 & 9 ord] to avoid frequ5t relapses :i* are always possible40 ,ess5tially ! same /atem5ts are made 9 ! m rec5t adv]tisem5ts 7f4 i4 ,urological & ,cutane\s ,review1 ,feb41 #aiai74 ,oppos$ to ^! loose /atem5ts are ! results ( ,ri*>d ,weil 7,! ,j\rnal ,a4 ,m4 ,a41 #aiac1 ,sept4 #bg1 p4 #ajcd2 ibid1 #aiae1 ,april #ag1 p4 #abhc74 ,weil avoid$ pitfalls ( subjective impressions & us$ z ! ess5tial crit]ion ( effici5cy 8! demon/rable r$uction 9 size ( a tumor1 ( a k9d n to be attribut$ to ! natural processes ( evolution ( t tumor or ( its associat$ lesions0 7l4 c4 #aiae1 p4 #abhi74 ,! available evid5ce = ,cuprase is f> f meet+ ?is crit]ion4 ,t publi%$ by ! manufactur]s & ag5ts pres5ts only vague g5]alities1 & no def9ite data4 ,! evid5ce ga!r$ by ,weil himself p]mits an e/imate ( ! value ( ,cuprase & x is entirely unfavorable4 ,he /ates 7l4c4 #aiae1 p4 #abhh73 8,colloidal copp] has be5 us$ 9 rec5t "t = ! same purpose by ,gaube du ,g]s & by o!rs4 ,i h rec5tly exam9$ ! effects ( colloidal copp] on malignant tumors 9 man1 & h be5 unable to f9d t x has any !rapeutic value4 ,fur!rmore1 a /udy ( ! di/ribution ( ! copp] 9 tumors obta9$ at op]ation or by necropsy f individuals s treat$ fail$ to %[ t ! copp] _h be5 deposit$ !re940 ,9 view ( ! extravagant & cruelly mislead+ !rapeutic claims1 & ! indef9ite /atem5ts ( composition1 ! ,c\ncil vot$ ,cuprase ineligible to ,n4 ,n4 ,r41 & au?oriz$ ! publication ( ?is report4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,april #ab1 #aiai47 ,,collosol ,,prep>ations ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has adopt$ & au?oriz$ publication ( ! report :i* appe>s bel[ decl>+ 8,collosol ,arg5tum10 8,collosol ,ars5icum10 8,collosol ,coca910 8,collosol ,cuprum10 8,collosol ,f]rum10 8,collosol ,hydr>gyrum10 8,collosol ,iod910 8,collosol ,manganese10 8,collosol ,qu990 & 8,collosol ,sulphur0 inadmissible to ,new & ,non(ficial ,rem$ies1 because _! composition is unc]ta9 7conflict ) ,rule #a74 ,9 ! few cases 9 :i* ! !rapeutic claims = ^! prep>ations 7 exam9$1 ! claims 7 f\nd to be s improbable or exagg]at$ 7conflict ) ,rules #f & #aj7 z to h necessitat$ ! rejection ( ^! products4 ,w4 ,a4 ,puckn]1 ,secret>y ,! ,anglo-,fr5* ,drug ,co41 ,ltd41 ,london & ,new ,york1 9 ,novemb]1 #aiah1 reque/$ ! ,c\ncil to consid] ! products 8,collosol ,arg5tum10 8,collosol ,ars5icum10 8,collosol ,coca910 8,collosol ,cuprum10 8,collosol ,f]rum10 8,collosol ,hydr>gyrum10 8,collosol ,iod910 8,collosol ,manganese10 8,collosol ,qu990 & 8,collosol ,sulphur40 ,! t]m 8,collosol0 appe>s to be a gr\p designation = :at are claim$ to be p]man5t colloidal solutions1 m>ket$ by ! ,anglo-,fr5* ,drug ,co41 ,ltd4 ,7 ?is claim correct1 8,collosols0 %\ld conta9 _! active con/itu5ts 9 ! =m ( microscopic or ultramicroscopic susp5sions1 protect$ aga9/ spontane\s precipitation by ! pres5ce ( prote9s or "s simil> 8/abiliz]s40 ,accord+ to ! orig9al pat5t specifications = ,collosols1 ! metals are precipitat$ or treat$ ) 8peptone10 :i* acts z ! susp5d+ or /abiliz+ ag5t4 ,! me?od ( us+ ! peptone makes x d\btful1 9 ! fir/ place1 :e!r ! major "p ( ! metals is pres5t 9 colloidal =m1 or m]ely 9 ! =m ( peptonates1 i4 e41 z ord9>y salts4 ,moreov]1 ! lat] pat5ts indicate t ! products h be5 unsatisfactory2 8exp]i5ce hav+ %[n t "s metal colloids "u c]ta9 conditions n yet fully und]/ood h ! t5d5cy to break d[n aft] a c]ta9 p]iod0 7,u4 ,s4 pat5t ,no4 #a1aaf1bdg74 ,ph5ol1 x is claim$ has a t5d5cy to c\nt]act ?is decomposition1 & ! pat5t cov]s ! use ( ph5ol = ?is purpose4 ,x is difficult to see h[ ph5ol c\ld possibly h su* action4 ,9 fact1 x obvi\sly does n1 = a numb] ( ! samples ( ,collosols submitt$ to ! ,c\ncil _h sep>at$4 ,= in/ance1 8,collosol ,hydr>gyrum0 0 n a colloidal solution at all1 b a susp5sion ( a co>se p[d]4 ,! ampules ( 8,collosol ,f]rum0 conta9$ a consid]able quantity ( floccul5t precipitate4 ,if ei!r ( ^! prep>ations 7 inject$ intrav5\sly z direct$1 dea? might result1 mak+ ! physician morally if n legally liable4 ,! recklessness ( ! claims is fur!r illu/rat$ by ! advice t ^! indef9ite mixtures ( poison\s metals c be inject$ 9 unlimit$ quantities4 ,?us1 ,h5ry ,crookes /at$ 7,*emical ,news1 ,may #g1 #aiad1 p4 #bah7 t ,collosols 8conta9 s small a proportion ( metal1 viz41 #a 9 #bjjj1 t ev5 a poison\s body l ars5ic c be us$ ) impunity40 ,he /at$ t !y may be appli$ z a lotion1 intramuscul> or intrav5\s injection1 & t 8"o p9t or m c be inject$ intrav5\sly40 ,9 ! case ( 8,collosol ,coca910 z 0 br\ght out 9 ! ,c\ncil's report publi%$ 9 ,! ,j\rnal1 ,april #ab1 #aiai1 ! manufactur]s h admitt$ t ! product is n :at !y h claim$--& /ill claim--= x4 ,! report ( ! ,a4 ,m4 ,a4 ,*emical ,laboratory %[$ t 8,collosol ,coca910 in/ead ( conta9+ #a p] c5t4 coca9 z claim$1 conta9$1 9 fact1 at mo/ n m ?an #j4d p] c5t4 coca94 ,! report ( ! ,a4 ,m4 ,a4 ,*emical ,laboratory on ! ,collosol products 0 s5t by ! ,c\ncil to ! ,new ,york (fice ( ! ,anglo-,fr5* ,drug ,co41 ,ltd41 9 duplicate 9 ord] to facilitate ref]5ce to ! ,london (fice4 ,?is 0 "s mon?s ago4 ,! in=mation :i* ! ,c\ncil reque/$ has n yet be5 receiv$1 nor has ! ,anglo-,fr5* ,drug ,co41 ,ltd41 indicat$ its int5tion ( supply+ su* in=mation4 ,on ! o!r h&1 claims to :i* specific objection h be5 made1 cont9ue to appe> 9 curr5t adv]tis+4 ,accord+ly1 ! ,c\ncil au?orizes publication ( ?is report1 & decl>es ! ,collosol prep>ations previ\sly nam$ ineligible to ,new & ,non(ficial ,rem$ies4 ,additional ,notes on ,collosol ,evid5ce ,9 addition to ! prec$+ ! foll[+ notes ( ! ref]ee on ! evid5ce s f> submitt$ 7 s5t to ! ,anglo-,fr5* ,drug ,company1 ,ltd41 = consid]ation3 ,collosol ,iod9e3 ,! leaflet :i* describes ,collosol ,iod9e conta9s claims t are improbable1 n 9 accord ) accept$ facts nor sub/antiat$ by evid5ce2 = in/ance3 8,?is prep>ation conta9s ,iod9e 9 its mo/ active =m 4440 8,! disadvantages ( #8iodism' & nausea frequ5tly associat$ ) iodides nev] occur ) ,collosol ,iod9e40 8,9 ! case ( ,colloidal ,iod9e ! :ole ( ! ,iod9e is absorb$ & ent]s into molecul> comb9ation ) prote9 to =m an iodo-am9o acid & 444 ex]ts a r$uc+ action on ! lipoids produc+ a diff]5t condition ( ! blood--h5ce ! use ( ,iod9e z an #8alt]ative'40 8,intrav5\sly ! action ( ,collosol ,iod9e is m rapid 444 9 cases ( pyemia 444 ?us %[+ its absolute non-toxicity40 8#8,p] se' ,colloidal ,iod9e is only slightly p>asitotropic & bact]iotropic b micro-organisms are v greatly influ5c$ by its action1 & n only is ! effect ( a subsequ5tly adm9i/]$ rem$y greatly increas$ b also ! insoluble colloidal prote9 ( s]um itself is r$uc$ to small] p>ticles1 ?us increas+ its surface & adsorptive capacity & consequ5t g]micidal p[]4 ,9 "s cases ! s]um1 ?us aid$1 is enabl$ to ?r[ (f a milk microbial invasion4 ,! above action c be readily demon/rat$ #89 vitro' by means ( ! ultramicroscope40 8,9 ,canc]1 ! intrav5\s injection ( ,collosol ,iod9e relieves pa91 ev5 :]e l>ge dosage ( morph9e is ineffective40 8,9 ,rheumatism ! ionic me?od ( treatm5t ) ,collosol ,iod9e is /rongly advis$40 8,9 ,recov]y f ,alcoholism ! int]nal adm9i/ration ( ,collosol ,iod9e re/ores ! normal condition ( cell activity1 ensur+ rapid recov]y40 ,collosol ,hydr>gyrum3 ,?is is said to be a prep>ation ( colloidal m]cury & w\ld !re=e be simil> to ,electrom]curol 7,new & ,non(ficial ,rem$ies1 #aiai1 p4 #afg74 ,colloidal m]cury prep>ations h be5 us$ to "s ext5t2 !y appe> to h no decid$ advantage ov] o!r1 noncolloidal1 m]cury comp\nds4 ,!y diff] suffici5tly f !m1 h[ev]1 to ju/ify acceptance = ,new & ,non(ficial ,rem$ies1 provid+ t reasonable claims are made = !m4 ,! leaflet adv]tis+ ,collosol ,hydr>gyrum conta9s /atem5ts t _c be accept$ & require ?or\gh revision to make !m acceptable4 ,! foll[+ are in/ances3 8,al?\gh--especially locally--! action ( m]curials is m>k$ly antiseptic1 :5 tak5 int]nally or inject$1 x has be5 /at$ by "s ( ! be/ kn[n au?orities1 t _! action is r to increase ! natural resi/+ p[] ( ! body to disease1 probably because ( /imulation ( ! oxidases40 ,) ! soluble m]curials 8consid]able upset ( ! normal cell conditions ( ! tissues ensues :il/ ^! soluble salts are be+ conv]t$ to a condition 9 :i* ! body c make use ( !m40 8,! colloidal /ate 444 is /at$ by "s au?orities 9 ! case ( m]cury to be inv>iably prec$5t to absorption4444 ,) ! usual =ms ( m]cury ! dang] ( too great a dose p] cell is consid]able1 b 9 ! case ( colloidal m]cury1 ! diffusion is extremely rapid & *emical aff9ity l[4 ,h5ce ! dang] to ! individual leucocyte is m9imiz$ & ! maximum effect obta9$40 8444 abs5ce ( pa9 is usual 9 ! adm9i/ration ( colloidal prep>ations & is due to _! isomorphism ) ! colloidal lipoid & prote9 ( ! tissues & body fluids40 8,accord+ to ,mc,donagh1444 m]cury acts z an oxidiz+ ag5t & t ! process ( oxidation is m effective 9 ! e>ly /ages ( syphilis 9 produc+ ! dea? ( ! causal organism44440 ,collosol ,manganese3 ,! circul> submitt$ to ! ref]ee is a repr9t ( a pap] by ,sir ,malcolm ,morris on 8,! ,treatm5t ( ,furunculosis & ,o!r ,deep-,seat$ ,coccog5ic ,infections by ,collosol ,manganese40 ,x reports f\r cases ( furunculosis1 ea* ( :i* cle>$ up aft] ! intramuscul> injection ( a few doses ( ,collosol ,manganese4 ,! au?or seems to attribute ! cure to ! manganese b ! evid5ce is n conv9c+4 ,ev5 ! au?or admits t1 9 ! treatm5t ( furunculosis 9 g5]al 8:5 at la/ ! dismal procession ends1 ?is (t5 appe>s to be less ! result ( treatm5t ?an because ! disease has run its natural c\rse40 ,unless mu* bett] evid5ce is 9 exi/5ce1 ! prep>ation mu/ be consid]$ to conflict ) ,rule #f1 :i* requires !rapeutic claims to be sub/antiat$4 ,collosol ,arg5tum3 ,! evid5ce submitt$ z to actions consi/s ( a s+le repr9t by ,roe1 :i* is n conv9c+1 & ?is fanta/ic /atem5t by ,boys3 8,a "y girl1 ag$ #ah1 came to my h\se ) acute inflammation ( "o eye ) an ulc] on ! cornea4 ,two drops ( ,collosol ,arg5tum 7 dropp$ 9 ! eye at #g p4 m41 & a pad plac$ ov] ! eye4 ,:5 %e came next morn+ ! eye 0 q well2 ! ulc] _h disappe>$1 & !re 0 no inflammation40 ,!re is no evid5ce t ?is prep>ation acts z catalyz] & assi/s ! natural resi/+ bodies ( ! tissues2 or t ^! are 8oxyg5 c>ri]s40 ,unless ! claims are support$ by bett] evid5ce1 !y1 9 ! op9ion ( ! ref]ee1 c\ld n be accept$4 ,!re h be5 submitt$ to ! ,c\ncil samples ( ! foll[+ metallic ,collosols3 ,,collosol ,,arg5tum ,,collosol ,,f]rum ,,collosol ,,ars5icum ,,collosol ,,hydr>gyrum ,,collosol ,,cuprum ,,collosol ,,manganese ,also ,collosols ( ,iod9e & ,sulphur1 & f9ally ,collosols ( ,coca9 & ,qu994 ,( all ! above1 except sulphur1 only ?ree small ampules h be5 submitt$4 ,?is does n admit ( any *emical exam9ation b a /atem5t ( ! physical appe>ance may be ( int]e/4 ,collosol ,ars5icum1 #j4b p] c5t43 ,v turbid ) l>ge quantities ( a lemon yell[ floccul5t precipitate4 ,on %ak+ does n become homog5e\s & rapidly sep>ates aga94 ,collosol ,arg5tum1 #a-bjjj3 ,! liquid has a slight opalesc5ce4 ,!re is consid]able deposit ( a heavy black precipitate4 ,does n become homog5e\s on %ak+ & ! black sub/ance quickly sep>ates aga94 ,collosol ,cuprum1 #j4e p] c5t43 ,d>k r$ some:at opalesc5t liquid4 ,no precipitate4 ,may be colloidal4 ,collosol ,f]rum1 #a-bjjj3 ,liquid cle>4 ,l>ge quantities ( d>k br[n floccul5t precipitate4 ,! precipitate is n di/ribut$ ev5ly :5 ! mixture is %ak5 & settles out quickly on /&+4 ,collosol ,hydr>gyrum1 #e p] c5t43 ,milky liquid4 ,l>ge quantities ( :ite deposit mix$ ) consid]able black4 ,! deposit mixes fairly well b ! great] "p settles out aft] /&+ an h\r or two4 ,collosol ,manganese1 #b4e-ajjj3 ,cle> r$di%-br[n liquid )\t deposit ( any k9d4 ,is n opalesc5t or fluoresc5t4 ,collosol ,iod91 #a-ejj3 ,v pale /raw color$ liquid )\t deposit4 ,has a slight opalesc5ce4 ,collosol ,sulphur1 #a-ajj3 ,liquid is opalesc5t4 ,!re is "s deposit ( yell[ p>ticles4 ,a f\r ounce bottle 0 also submitt$4 ,! liquid 9 ?is bottle is milky ) consid]able deposit ( yell[ cry/als l ord9>y cry/all9e sulphur4 ,collosol ,coca91 #a-ajj3 ,transp>5t1 colorless liquid ) no deposit4 ,*emical exam9ation %[$ #j4d p] c5t4 ( :at may h be5 coca94 ,?is residue gave alkaloidal te/s4 ,collosol ,qu991 #a-ajj3 ,slightly opalesc5t1 colorless liquid1 ) no deposit4 ,gives alkaloidal reactions4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,june #g1 #aiai47 ,,pulvoids ,,calcylates ,,comp\nd ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has au?oriz$ publication ( ! foll[+ report1 n s mu* because ! prep>ation ) :i* x deals is ( any great importance1 b z a prote/ aga9/ ! l>ge numb] ( simil> irrational complex mixtures :i* are /ill (f]$ to physicians4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,pulvoids ,calcylates ,comp\nd 7,! ,drug ,products ,co41 ,inc47 are tablets ea* ( :i* is claim$ to conta93 8,calcium & ,/rontium ,disalicylate1 #e grs42 ,res9 ,guaiac1 #a_/b gr42 ,digitalis1 #a_/d gr42 ,co*ium col*icum8 ,se$1 #a_/d gr42 ,squill1 #a_/d gr42 ,casc>91 #a_/af gr4 ) aromatics40 8,pulvoids ,calcylates ,comp\nd 7,sug> coat$ orange color70 is adv]tis$ 7,m$ical ,times1 ,janu>y1 #aiai7 z be+ 8,analgesic-,antipyretic & ,diuretic10 & is includ$ 9 ! prep>ations designat$ by ! adv]tis] z 8,approv$ ,rem$ies = ,la,grippe & #8,flu4'0 ,! claim t 8,_! tol]ance is rem>kable0 ref]s n to ! physicians :o tol]ate su* products1 b to ! alleg$ fact t ,pulvoids ,calcylates are tol]at$ rem>kably well4 ,! adv]tisem5t cont9ues3 8,may be giv5 p]si/5tly & cont9u\sly )\t ga/ric di/urbances40 8,!y are uni=mly effici5t4 ,m c]ta9 9 effect ?an ! ord9>y ,salicylates40 ,x w\ld be difficult to f9d an adv]tisem5t ( equal l5g? conta9+ a great] numb] ( mislead+ or directly false /atem5ts ?an are f\nd 9 ?is "o4 ,! ,j\rnal 7,april #bb1 #aiaf1 p4 #acjg7 has call$ att5tion to ! lack ( ju/ification = ?is absurd mixture ( drugs & has discuss$ ! prep>ation ) especial ref]5ce to its use 9 acute rheumatism1 9 :i* ! salicylates occupy a special field4 ,! adv]tisem5t j quot$ m5tions ,la ,grippe & 8,flu0 7or ,influ5za7 z special fields ( usefulness = ?is prep>ation4 ,?is1 app>5tly1 is m]ely an attempt to spread ! sail = any breeze4 ,salicylates h a field ( usefulness 9 influ5za 9 t !y (t5 af=d relief f pa94 ,!re is no reason to suppose t a mixture conta9+ calcium & /rontium salicylates--! 8,calcium & ,/rontium ,disalicylate0 ( ,pulvoids ,calcylates is probably a mixture ( calcium & /rontium salicylate#abg--;has any great] salicylic effect ?an an equal am\nt ( sodium salicylate4 ,on ! o!r h&1 x is worse ?an useless to give col*icum1 squill & digitalis = ! relief ( su* pa9s4 #abg ,see report1 ,! ,j\rnal1 ,sept4 #i1 #aiaf1 p4 #hbg4 ,%\ld c>diac dilatation develop1 & digitalis m$ication be requir$ x w\ld be impossible to adju/ ! dose ( su* a mixture ) special ref]5ce to ! digitalis action1 :i* alone w\ld be indicat$ = t condition4 ,no educat$ physician at pres5t w\ld ?9k ( giv+ res9 ( guaiac m]ely because 8 pati5t requir$ digitalis1 nor w\ld he adm9i/] 8casc>910 :atev] t may be1 9 fix$ doses1 e "t he gave a dose ( salicylate4 ,x is impossible to recognize ! sev]al effects induc$ by ?is !rapeutic omneity1 & ! m$ical pr(ession %\ld consid] x an insult to be (f]$ mixtures su* z ,pulvoids ,calcylates ,comp\nd4 ,pulvoids ,calcylates ,comp\nd is1 p] se1 ( no great importance2 x is "o ( a type4 ,x has be5 select$ z "o ( ! utt]ly irrational & !re=e pot5tially dang]\s mixtures1 t may be f\nd by ! score or ! hundr$ 9 ! catalogues ( practically e ph>maceutical manufactur+ firm 9 ! ,unit$ ,/ates4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,june #ad1 #aiai47 ,,proteog5s ,,( ,,! ,,wm4 ,s4 ,,m]rell ,,company ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has adopt$ & au?oriz$ publication ( ! /atem5t :i* appe>s bel[1 decl>+ ,proteog5 ,no4 #a 7,plantex7 = ,canc]1 ,proteog5 ,no4 #b = ,rheumatism1 ,proteog5 ,no4 #c = ,tub]culosis1 ,proteog5 ,no4 #d = ,hay ,fev] & ,bron*ial ,a/hma1 ,proteog5 ,no4 #e = ,d]matoses1 ,proteog5 ,no4 #f = ,*lorosis1 ,proteog5 ,no4 #g = ,second>y ,anemia1 ,proteog5 ,no4 #h = ,p]nici\s ,anemia1 ,proteog5 ,no4 #i = ,goitre1 ,proteog5 ,no4 #aj = ,syphilis1 ,proteog5 ,no4 #aa = ,gonorrhea1 & ,proteog5 ,no4 #ab = ,influ5za & ,pneumonia inadmissible to ,new & ,non(ficial ,rem$ies because _! composition is secret2 because ! !rapeutic claims made = !m are unw>rant$2 & because ! secrecy & complexity ( _! composition makes ! use ( ^! prep>ations irrational4 ,! ,c\ncil took up ! consid]ation ( ! ,m]rell ,proteog5s because ( inquiries receiv$1 & on ,janu>y #bg invit$ ! ,m]rell ,company to aid 9 ! propos$ inve/igation by submitt+ in=mation 9 reg>d to ! composition ( ! prep>ations1 submitt+ ! curr5t adv]tis+1 & pres5t+ evid5ce = ! claims t 7 made = ! prep>ations4 ,:ile ! ,m]rell ,company agre$ to submit ! reque/$ in=mation1 ?is _h n be5 receiv$ at ! "t ! report ( ! ref]ee to :om ! products _h be5 assign$ 7,ref]ee #a71 0 adopt$4 ,?is report 0 s5t to ! company on ,april #d4 ,9 reply ! ,m]rell ,company prote/$ aga9/ ! conclusions ( ! report & submitt$ consid]able mat]ial 9 an attempt to support ! claims made = ! products4 ,?is mat]ial 0 exam9$ by ! fir/ ref]ee & !n transmitt$ to a second ref]ee 7,ref]ee #b7 = consid]ation4 ,! second ref]ee conclud$ t ! matt] submitt$ (f]$ no evid5ce t w\ld ju/ify ! ,c\ncil 9 modify+ ! report fir/ adopt$1 & h5ce recomm5d$ t its publication be au?oriz$4 ,9 accordance ) ?is recomm5dation 7report ( ,ref]ee #b7 ! ,c\ncil au?oriz$ ! publication ( ! reports ( bo? ! fir/ & second ref]ees4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,report ( ,fir/ ,ref]ee on ,proteog5s 8,proteog5s10 accord+ to ! ,william ,s4 ,m]rell ,co41 are 8,polyval5t ,prote9s ( ,non-,toxic ,plant ,orig940 ,! subject ( ,proteog5s c be/ be approa*$ by recall+ ! hi/ory ( 8,autolys910 an alleg$ rem$y = canc]1 orig9at$ by ,a4 ,s4 ,hor[itz1 ,ph4,d4 ,?is 0 exploit$ "s ye>s ago1 & 0 f9ally %[n to be wor?less4 ,proteog5s are said to be prep>$ 8"u ! p]sonal sup]vision ( ! orig9ator1 ,dr4 ,a4 ,s4 ,hor[itz40 ,! composition ( ! diff]5t ,proteog5s is ess5tially secret4 ,! ass]tion 0 made at "o "t1 b is n f\nd 9 ! pres5t adv]tis+ matt]1 t ,plantex--n[ call$ 8,proteog5 ,no4 #a0--;is simil> to ,autolys94 ,n[ ! ,proteog5s are said to be 8prep>$ by a special process employ+ v>i\s comb9ations ( plants40 ,fur!r3 ,! biologic pr9ciples pres5t are *lorophyll1 *romopla/1 lipoids & vitam9es2 ^! are f]m5ts or enzymes4 ,! vegetable acids1 metalloids & metals pres5t 9 all plants 9 colloid =m act bio*emically4 ,among ! metalloids are hydrog51 c>bon1 manganese1 oxyg51 sulphur1 phosphorus & *lor9e2 ! heavy metals are iron1 potassium1 sodium1 magnesium & copp]4 ,^! bio*emic pr9ciples are always pres5t 9 plants z colloids40 ,x is claim$ by ! ,m]rell ,company t3 8,proteog5s /imulate ! cytog5ic me*anism to high] activity2 !re=e1 indirectly cleave ! invad+ microorganism & elim9ate _! special tox9s4 ,proteog5s sw+ ! di/urb$ metabolism back to normal &1 by natural processes1 build up effective def5ses aga9/ recurr5t bact]ial attacks40 ,proteog5 ,no4 #a 0 fir/ introduc$ z 8,plantex10 & at t "t ! ,m]rell ,company ref]r$ to a prep>ation t 0 ! result ( 8a s]ies ( /udies0 c>ri$ out by a 8not$ biologi/0 ) a view ( 8evolv+ a ,canc] rem$y0 t 0 8to be autolytic 9 "*10 & ann\nc$3 8,! ,h\se ( ,m]rell always int]e/$ 9 ! progress ( plant !rapy1 began ph>macological exp]im5tations to reproduce ?is same sub/ance4 ,! qualitative & quantitative analysis ( ! sub/ance z us$ 9 ,new ,york hav+ be5 publi%$ simplifi$ matt]s4 ,a some:at simil> rem$y has n[ be5 prep>$4 ,x consi/s ( ! foll[+ sub/ances--,m5yan!s trifoliata ,buckbean1 ,melilotus (fic9alis ,yell[ sweet clov]1 ,m5?a crispa ,curl$ m9t1 ,brassica alba ,:ite mu/>d1 ,anemone hepatica ,liv] leaf1 ,viola tricolor ,pansy1 ,an!mis ,roman *amomile1 ,fructus colocyn?idis ,colocyn?1 ,lignum quassi ,quassia1 ,urtica dioica ,nettle1 ,radix rhei ,rhub>b root1 ,h$ge hyssop4 ,^! sub/ances are 9 approximately equal proportions ) ! exception ( ! mu/>d :i* =ms #bj p] c5t4 ( ! mixture1 & ! colocyn? fruit :i* is #e p] c5t40 ,) respect also to ! o!r ,proteog5s li/$ above1 /udy ( m$ical lit]ature reveal$ no evid5ce e/abli%+ _! !rapeutic value2 9 fact1 no evid5ce 0 f\nd o!r ?an t appe>+ 9 ! adv]tis+ matt] ( ! manufactur]4 ,! range ( diseases 9 :i* ,proteog5s are recomm5d$ is s wide z to make obvi\s ! lack ( sci5tific judgm5t :i* *>act]izes _! exploitation4 ,a circul> lett]1 receiv$ ,janu>y1 #aiai1 rem9d$ ! physician t ab\t a ye> ago 8 att5tion _h be5 direct$ to ,proteog5 ,no4 #a = canc]1 t lat] developm5ts enabl$ ! firm to recomm5d = 8 consid]ation 8a s]ies ( ,proteog5s 7,nos4 #b to #i710 & t n[ 8,9 response to an insi/5t dem&1 ,dr4 ,a4 ,s4 ,hor[itz has prep>$ two new ,proteog5s--,no4 #aj = ,syphilis & ,no4 #aa = ,gonorrhea40 ,a po/script to ?is circul> lett] ann\nc$ ano!r prep>ation1 8,proteog5 ,no4 #ab = ,influ5za & ,pneumonia10 a 8developm5t out ( ! pres5t influ5za epidemic10 & admitt$ t 8,x has n _h ! cl9ical exp]im5tation t prec$es our introduction ( a new product40 ,! introduction ( ,no4 #ab 0 effect$ by means ( a special bullet9 :i* consi/s exclusively ( cl9ical reports f sev5 physicians1 all f ,*icago save "o1 & all purport+ to %[ mo/ favorable results f ,no4 #ab4 ,!y describe cases :i* any physician ) exp]i5ce ) influ5za c duplicate )\t any special treatm5t4 ,x is difficult to give s]i\s consid]ation to a set ( alleg$ rem$ies :5 ! only evid5ce is t furni%$ by ! propon5ts ( ! alleg$ rem$ies4 ,?is is p>ticul>ly true :5 ! alleg$ rem$y does n make a suffici5t appeal to "o's s5se ( ! rational 9 !rapeutics to lead "o to feel ju/ifi$ 9 ask+ a trial at ! h&s ( c>eful cl9ical obs]v]s4 ,consid]+ ! grave nature ( ! diseases = :i* ,proteog5s are recomm5d$1 p>ticul>ly canc]1 tub]culosis1 & p]nici\s anemia1 ! want ( a rational basis = ! me?od ( treatm5t & ! g5]al t5or ( ! adv]tis+ matt]1 x appe>s safe to conclude t ^! ag5ts d n repres5t any def9ite advance 9 !rapeutics4 ,z ! use ( prep>ations1 secret 9 composition1 & ( no e/abli%$ value1 is contr>y to rational !rapy1 x is recomm5d$ t ! ,proteog5 prep>ations be decl>$ 9 conflict ) ,rules #a1 #f & #aj4 ,report ( ,second ,ref]ee ,review+ ,manufactur]s' ,reply ,! report decl>+ ! ,proteog5s ( ! ,william ,s4 ,m]rell ,company inadmissible to ,new & ,non(ficial ,rem$ies 0 adopt$ by ! ,c\ncil1 b be=e publication x 0 s5t to ! ,m]rell ,company = su* comm5ts z x might desire to make4 ,9 due "t ! reply ( ! firm 0 receiv$4 ,x consi/$ ( two volumes b\nd 9 limp morocco1 ea* /amp$ 9 gold3 8,report ,proteog5 ,!rapy ,reque/$ by ! ,am]ican ,m$ical ,association1 #aiai2 ,! ,wm4 ,s4 ,m]rell ,company40 ,! fir/ volume conta9$ #gi pages ( typewritt5 mat]ial2 ! second volume conta9$ #gf pages ( typewritt5 mat]ial & a numb] ( adv]tis+ booklets put out by ! ,wm4 ,s4 ,m]rell ,company1 exploit+ ! ,proteog5s4 ,among ! typewritt5 mat]ial 0 a #ad-page report on 8,proteog5 ,!rapy0 by its orig9ator1 ,a4 ,s4 ,hor[itz4 ,foll[+ ?is !re are sev]al pages devot$ to :at is t]m$ 8a %ort qualitative description ( ! +r$i5ts ( major importance 9 ,proteog5s40 ,!n foll[s a page describ+ ! adv]tis+ ( ,proteog5s1 & ! rema9d] ( ! two books is devot$ to te/imonials1 laud+ ! b5efit ( ,proteog5s 9 diseases su* z canc]1 tub]culosis1 rheumatism1 a/hma1 influ5za1 enl>g$ pro/ate1 rheumatic endoc>ditis1 syphilis1 eczema1 psoriasis1 diabetes1 second>y anemia1 gonococcic infections1 etc4 ,f9ally1 !re are atta*$ samples ( adv]tis+ pamphlets4 ,! diss]tation by ,a4 ,s4 ,hor[itz conta9s little actual in=mation conc]n+ ^! sub/ances1 b is conc]n$ pr9cipally ) discussion ( =eign prote9s1 8antif]m5ts10 8non-specific prote9s10 8anti-virol9s0 & speculations on _! hypo!tical actions & int]actions on ea* o!r & on ! organs ( ! body & on bact]ia4 ,! report conta9s _m que/ionable /atem5ts4 ,"o f9ds 9 ?is report b few def9ite /atem5ts ( facts :i* are kn[n to be accurate or :i* c\ld be accept$ )\t "q4 ,! qualitative description ( ! prote9s & _! compon5ts is z vague z ! previ\s discussion4 ,! diff]5tiation betwe5 ! v>i\s ,proteog5s is extremely indef9ite2 t = ,tub]culosis1 ,no4 #c is describ$ z 8polyval5t1 non-specific prote9 :i* rapidly attacks ! acid-fa/1 encapsulat$ tub]cle bacilli02 ,proteog5 ,no4 #aj = syphilis is said to be a comb9ation ( 8non-specific plant prote9s & diff]5t *emicals :i* has ! p[] to p>alyze & de/roy liv+ spiro*ete40 ,x is /at$ t ,proteog5s are sci5tific prep>ations bas$ on /&>d +r$i5ts & t ! /&>dization is m accurate ?an 9 s]ums1 vacc9es or tox9s1 etc4 ,! report gives no pro( ( su* /atem5ts4 ,! te/imonials t are submitt$ are typical ( 8reports0 t manufactur]s are able to obta9 f "s physicians1 to prove ! efficacy ( almo/ any prep>ation 9 any disease4 ,ea* consi/s1 practically1 ( ! op9ion ( ! individual :o has employ$ ! ,proteog5s or ! op9ion ( ! pati5t :o has be5 treat$4 ,few data are giv5 9 ^! reports f :i* an imp>tial conclusion might be drawn4 ,a few ( ! te/imonials pres5t$ by ! ,william ,s4 ,m]rell ,company foll[4 ,! valuelessness ( su* mat]ial z sci5tific evid5ce is obvi\s3 ,,rheumatism3--,proteog5 ,no4 #b4--,! ,doctor has "o case be+ treat$ ) ,no4 #b4 ,%e has improv$ s rapidly %e _c express h] pleasure1 & w cont9ue = "s "t on ! treatm5ts4 ,%e is a pati5t :o 0 conf9$ dur+ ! "t %e suff]$ f a rheumatic illness1 & x seem$ to affect h] m5tal condition4 ,?is condition is cle>+ up also1 v mu* to ! pleasure ( bo? pati5t & doctor4--,novemb] #bg1 #aiah4 ,,influ5za3--,proteog5 ,no4 #ab4--;,fir/ day1 temp]ature #ajb1 gave #a c4c4 ,proteog5 ,no4 #ab2 second day1 temp]ature #ajj1 gave #a c4c4 ,proteog5 ,no4 #ab2 ?ird day1 temp]ature #ih4h1 gave #a c4c4 ,proteog5 ,no4 #ab1 & !n dis*>g$ ! case z recov]$4--,octob] #ca1 #aiah4 ,,a/hma3--,proteog5 ,no4 #d4--,spl5did results obta9$ f a sample ( ,proteog5 ,no4 #d4 ,?ree amp\les affect$ effect$8 complete recov]y4--,octob] #i1 #aiah4 ,,canc]3--,proteog5 ,no4 #a4--,mrs4 ,b4 pron\nc$ recov]$ f ,canc] by ,dr4 ,o4 ,w4 ,a41 ( ,catl91 aft] hav+ injections ( ,proteog5 ,no4 #a = "s "t4--,octob] #d1 #aiah4 ,,eczema3--,proteog5 ,no4 #e4--,tri$ ,no4 #e on a pati5t ) eczema1 & ) happy results4 ,h n done any?+ = him = ab\t five mon?s--& he is n[ at 8 bus9ess4 ,proteog5 ,no4 #e also ,,reliev$ ,,him ,,( ,,con/ipation ,,& ,,:at ,,he ,,claim$ ,a ,,traumatic ,,/ricture ,,( ,,! ,,l[] ,,portion ,,( ,,sigmoid ,,flexure4 ,he is sure pleas$ & recomm5d+ !m to 8 fri5ds4 7,proteog5s74--,febru>y #ag1 #aiai4 ,,syphilis3--,proteog5 ,no4 #aj4--;,i am gett+ su* excell5t results ) ! ,no4 #aj ,proteog5 = ,syphilis t ,i am badly 9 ne$ ( m1 z ,i am treat+ s _m cases4 ,please s5d me f\r doz5 ,c4 ,o4 ,d4--,octob] #i1 #aiah4 ,,enl>g$ ,,pro/ate3--,proteog5 ,no4 #a4--;,h us$ ,plantex 9 f\r cases1 ) good results 9 ea* case4 ,"o ( !m 8 fa!r1 an eld]ly man4--,april #be1 #aiah4 ,,lob> ,,pneumonia3--,proteog5 ,no4 #ab4--,! only case ,i h us$ ,proteog5 ,no4 #ab1 0 a man :o _h ,lob> ,pneumonia ( left lung foll[+ ,influ5za4 ,aft] crisis came1 pati5t cont9u$ to h slight rise 9 temp]ature1 c\gh1 & aft] us+ #aj doses ( y\r ,proteog5 ,no4 #ab1 temp]ature 0 normal1 c\gh v mu* bett]1 pati5t began to take on fle% & is /ill improv+4--,decemb] #bf1 #aiah4 ,,tub]culosis3--,proteog5 ,no4 #c4--,! ,doctor writes3 ,! ,proteog5 ,no4 #c s5t me work$ wond]s 9 my pati5t4 ,! case came "u my c>e :5 he 0 too f> gone = any?+ to b5efit him a great deal1 b ! ,proteog5 did = him m ?an anyone c\ld h expect$1 yet he di$ leav+ me ) a few amp\les to try on ! next pati5t4--,septemb] #bj1 #aiah4 ,,gonorrheal ,,cy/itis3--,proteog5 ,no4 #aa4--,my pati5t has tak5 two boxes ( y\r ,proteog5 ,no4 #aa giv5 = gonorrheal cy/itis ( probably two ye>s' /&+ & at ?is writ+ ,i consid] h] almo/1 if n entirely1 cur$ :i* ,i ?9k speaks v highly ( y\r rem$y4 ,i expect to use m ( y\r prep>ations 9 ! future4--,april #ab1 #aiai4 ,?is te/imonial1 ei!r by cl]ical error1 or because ! results 7 consid]$ rem>kable1 0 repeat$ else:]e 9 ! mat]ial submitt$ by ! ,m]rell ,company4 ,,acute ,,gonorrhea3--,proteog5 ,no4 #aa4--,mr4 ,a4 ,e4 ,r41 age #fe1 weight #adj p\nds4 ,fir/ attack4 ,_h _h no previ\s treatm5t4 ,came to me ,janu>y #b1 #aiai4 ,_h dis*>ge1 all acute symptoms1 burn+1 etc4 ,gave sev5te5 injections ( ,proteog5 ,no4 #aa1 also mild antiseptic ure?ral wa%4 ,dis*>g$ on ,febru>y #ae1 #aiai1 cl9ically cur$4--,april #aa1 #aiai4 ,,epi!lioma ,,( ,,buttock4--,proteog5 ,no4 #a4--;,i us$ ,proteog5 ,no4 #a on an epi!lioma ( buttock "s six mon?s ago ) favorable results & no return ( symptoms z yet4--,april #ac1 #aiai4 ,x is obvi\s t ! ,proteog5 prep>ations are 9 conflict ) ,rules #a1 #f & #aj1 & %\ld n be admitt$ to 8,new & ,non(ficial ,rem$ies40 ,x is recomm5d$ t ! previ\s action ( ! ,c\ncil be all[$ to /& & t publication ( bo? reports be au?oriz$4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,july #ab1 #aiai7 8,,ars5ov5 ,s4 ,s40 ,,& 8,,ars5o-,,me?-,,hyd0 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil au?orizes publication ( ! foll[+ report4 ,?is report decl>es ,ars5ov5 ,s4 ,s4 ( ! ,s4 ,s4 ,products ,company & ,solution ( ,ars5ic & ,m]cury 7=m]ly call$ ,ars5o-,me?-,hyd7 ( ! ,new ,york ,intrav5\s ,laboratory1 inadmissible to ,new & ,non(ficial ,rem$ies4 ,! ,c\ncil takes ?is opportunity to repeat its w>n+ aga9/ ! abuses--(t5 dang]\s--to :i* pati5ts are frequ5tly subject$ :5 8intrav5\s !rapy0 is employ$4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,because ( inquiries receiv$1 ! ,c\ncil took up ! consid]ation ( ,ars5ov5 ,s4 ,s4 & ,ars5o-,me?-,hyd 7n[ sold z ,solution ( ,ars5ic & ,m]cury74 ,! prep>ations hav+ be5 ref]r$ to a committee = consid]ation1 ?is committee report$3 ,,ars5ov5 ,s4 ,s4 8,ars5ov5 ,s4 ,s40 is a prep>ation put out by ! ,s4 ,s4 ,products ,company1 ,philadelphia4 ,! claims are made t x is 8a simplifi$ (fice treatm5t = syphilis0 & is 8a comb9ation ( ars5ic & m]cury = (fice use1 (f]+ maximum effici5cy1 safety & conv5i5ce40 ,accord+ to ! company1 8,ars5ov5 ,s4 ,s40 conta9s ,dime?yl>s59 #ae4d gra9s1 ,m]cury b9iodid #a_/aj gra91 ,sodium iodid #a_/b gra94 ,) reg>d to ! id5tity ( 8dime?yl>s590 ! company claims3 8,?is product is a comp\nd ( cacodylic acid simil> to sodium cacodylate b ) a m pron\nc$ !rapeutic action40 ,! committee recomm5ds to ! ,c\ncil t 8,ars5ov5 ,s4 ,s40 be decl>$ inadmissible to ,new & ,non(ficial ,rem$ies because ( unw>rant$ !rapeutic claims4 ,,ars5o-,,me?-,,hyd 8,ars5o-,me?-,hyd10 is sold by ! ,new ,york ,intrav5\s ,laboratory1 ,new ,york ,city1 = ! treatm5t ( syphilis4 ,x comes 9 ?ree dosages1 #b gm41 #a4e gm41 & #j4g gm41 respectively4 ,! claim is made t 8,ars5o-,me?-,hyd #b gm40 conta9s 8#b gm4 7#ca gra9s7 ( ,sodium ,dime?yl>s5ate 7,cacodylate71 ,u4 ,s4 ,p44 & ,m]cury ,iodid #e mg4 7#a_/ab gra970 9 #e c4c4 ( solution4 ,physicians are told3 8,9 prim>y & e>ly second>y case adm9i/] ,ars5o-,me?-,hyd #b gm4 e six? day & ,m]cury ,oxycyanide 4#jjh 7#a_/h gra97 intrav5\sly betwe5 ea* injection40 8,9 ,t]ti>y cases & ^? ( long /&+ alt]nate ) intrav5\s injection ( ,sodium ,iodid #b gm40 ,! foll[+ claims are made = ! alleg$ effectiv5ess & safety ( ! cacodylate3 8,?is me?yl comp\nd ( ars5ic has come into almo/ univ]sal use = syphilis4 ,on acc\nt ( lack ( toxicity an aggressive r\t9e c be c>ri$ on4 ,! simple te*nic & abs5ce ( reactions make x mo/ desirable = ! regul> practition]4 ,?is l>ge dose gives m uni=m results bo? z heal+ manife/ations & negative ,wass]mann's40 8,mu* discussion has surr\nd$ ! use ( ,me?yl ,comp\nds ( ,ars5ic & x has be5 demon/rat$ beyond d\bt t ,cacodylate ( ,soda proves an effective rem$y = syphilis provid$ t x is prop]ly adm9i/]$40 sic 8,! l[ toxicity ( ?is ,me?yl comp\nd ( ars5ic is rem>kable4 ,x is contra9dicat$ only :]e a decid$ idiosyncrasy = ev5 small doses ( ars5ic exi/s40 ,^! /atem5ts are ess5tially false & mislead+4 ,cacodylate has n come into univ]sal use 9 ! treatm5t ( syphilis1 nor has its usefulness be5 8demon/rat$ beyond d\bt40 ,on ! contr>y1 ,h4 ,n4 ,cole 7,! ,j\rnal1 ,dec4 #cj1 #aiaf1 p4 #bjab7 has %[n t doses s l>ge z to produce r5al injury 7 almo/ totally ineffective aga9/ syphilis4 ,obvi\sly1 8effective doses0 if su* exi/1 are n h>mless4 ,! dosage advis$ = ,ars5o-,me?-,hyd may n produce acute toxic symptoms2 nev]!less small] doses h produc$ nephritic ph5om5a4 ,! 8,ars5o-,me?-,hyd0 treatm5t includes ! intrav5\s injection ( ab\t #a_/d gra9 ( a m]cury salt4 ,al?\gh ?is is less ?an ! usual dose 7ab\t #a gra9 p] week71 ! m]cury is probably m effective ?an ! cacodylate4 ,! committee recomm5ds to ! ,c\ncil t1 because ( ! unw>rant$ !rapeutic claims1 8,ars5o-,me?-,hyd0 be held inadmissible to ,new & ,non(ficial ,rem$ies4 ,! ,c\ncil adopt$ bo? reports ( ! committee & decl>$ 8,ars5ov5 ,s4 ,s40 & 8,solution ( ,ars5ic & ,m]cury0 78,ars5o-,me?-,hyd07 inadmissible to ,new & ,non(ficial ,rem$ies4 ,! committee's reports on ^! two products impel ! ,c\ncil aga9 to call att5tion to ! undesirable & dang]\s abuses to :i* 8,intrav5\s ,!rapy0 l5ds itself4 ,!re is a di/9ct field = ! intrav5\s adm9i/ration ( drugs 9 ^? cases 9 :i* imm$iate drug action is necess>y1 or :5 ! m$icam5t is likely to be *ang$ if absorb$ ?r\gh ! ord9>y *annels4 ,unless su* indications exi/1 h[ev]1 intrav5\s adm9i/ration involves n only inconv5i5ce & exp5se to ! pati5t1 b :at is m important1 unnecess>y dang]4 ,! fact t indiscrim9ate intrav5\s adm9i/ration is peculi>ly pr(itable to c]ta9 manufactur+ h\ses makes x all ! m necess>y = ! m$ical pr(ession to be on its gu>d 9 ?is matt]4 ,9 ?is connection x is well wor? :ile to quote ! clos+ p>agraph f an editorial on 8,intrav5\s ,!rapy0 t appe>$ 9 ,! ,j\rnal1 ,nov4 #aa1 #aiaf4 ,x is z true today z :5 x appe>$3 8,intrav5\s !rapy w be mo/ securely advanc$ if its employm5t is re/rict$ to su* well def9$ fields4 ,z ^? m5tion$ above4 ,^! fields c be satisfactorily det]m9$ only by a sci5tific ph>macologic /udy ( ! action ( ^! drugs :5 s adm9i/]$ 9 animals1 z well z 9 man1 "u conditions 9 :i* ! results are c>efully controll$4 ,! intrav5\s me?od is an impressive "o1 approa*+ 9 prep>ation almo/ to t :i* goes ) a surgical op]ation4 ,! pati5t is usually int]e/$ & impress$ by ?is new1 &1 to him1 my/]i\s me?od4 ,!re is a psy*ic elem5t 9 8 reaction to ! injection :i* is n a factor 9 8 reaction to ! same drug :5 giv5 by m\?4 ,! intrav5\s injection ( a complex mixture w\ld appe> to be p>ticul>ly repreh5sible4 ,little is kn[n1 z has be5 /at$1 ( ! results to be expect$ f intrav5\s !rapy1 ev5 ) simple sub/ances4 ,! use ( complex mixtures w )\t d\bt react aga9/ ! prop] use ( ! me?od40 ,aft] ! report on ,ars5o-,me?-,hyd _h be5 pres5t$ to ! ,c\ncil1 a lett] 0 receiv$ f ! ,new ,york ,intrav5\s ,laboratory ann\nc+ t ! prep>ation 8,ars5o-,me?-,hyd0 0 n[ call$ 8,solution ( ,ars5ic & ,m]cury0 & express+ a desire to h its products accept$ = inclusion 9 ,new & ,non(ficial ,rem$ies4 ,9 view ( ?is lett]1 ! committee's report on 8,ars5o-,me?-,hyd0 & ! ,c\ncil's prote/ aga9/ promiscu\s intrav5\s !rapy 7 s5t ! ,new ,york ,intrav5\s ,laboratory = consid]ation4 ,! reply ( ! ,new ,york ,intrav5\s ,laboratory conta9$ no?+ :i* p]mitt$ a revision ( ! prec$+ report4 ,! *ange ( ! "n ( 8,ars5o-,me?-,hyd0 to 8,solution ( ,ars5ic & ,m]cury0 means little z ! "n /ill does n disclose ! important fact t ! ars5ic is pres5t z sodium cacodylate1 nor does x tell ! "* ( ! m]cury comp\nd4 ,! ,c\ncil vot$ t 8,solution ( ,ars5ic & ,m]cury0 & 8,ars5ov5 ,s4 ,s40 be decl>$ inadmissible to ,new & ,non(ficial ,rem$ies because ! !rapeutic claims advanc$ = !m are unw>rant$ 7,rule #f7 & because ! names ( ^! ph>maceutical prep>ations are n descriptive ( _! composition 7,rule #h74 ,9 fil+ its reply ) ! ,c\ncil1 ! ,new ,york ,intrav5\s ,laboratory ann\nc$ t t docum5t w\ld be circulat$ to ! m$ical pr(ession4 ,?is is ( c\rse ! firm's privilege4 ,! ,c\ncil notes1 h[ev]1 ) int]e/1 t ! reply is devot$ almo/ entirely to po9ts :i* 7 n rais$ by ! ,c\ncil & t x fails to discuss ! objections :i* 7 actually made4 ,! reply con/antly confuses ! effici5cy ( cacodylate 9 anemia & 9 syphilis4 ,! ,c\ncil's report on 8,ars5o-,me?-,hyd0 does n discuss or ev5 t\* on ! "q ( cacodylates 9 anemia4 ,x is conf9$ to a discussion ( ! disappo9t+ results obta9$ ) cacodylates z su* 7i4 e41 )\t m]cury7 9 ! treatm5t ( syphilis4 ,?is attempt on ! "p ( ! ,new ,york ,intrav5\s ,laboratory to confuse ! issue & to attribute to ! ,c\ncil an op9ion t x has nev] /at$ or held is an inexcusable misrepres5tation4 ,! company 9 its reply said3 8,we believe t y h previ\sly /at$ t a solution cacodylate ( soda possesses no m action ?an s mu* wat]4 ,9 o!r words1 x 0 in]t4 ,n[ y try to %[ t x produces r5al injury40 ,! ,c\ncil has nev] decl>$ t cacodylates are in]t4 ,9 ! report x is m]ely /at$ 8t doses s l>ge z to produce r5al injury 7 almo/ totally ineffective aga9/ syphilis40 ,nei!r has ! ,c\ncil /at$ t cacodylate is 8peculi>ly dang]\s40 ,9 fact ! absolute toxicity ( cacodylates is l[ b ,cole's results 7 quot$ z a caution t 8effective0 doses are n h>mless4 ,a great portion ( ! rema9d] ( ! reply is devot$ to disp>ag+ arsph5am9--a product t is n involv$ 9 ?is action ( ! ,c\ncil1 & "o ab\t :i* ! physician is amply in=m$4 ,among/ o!r :olly extrane\s matt]s1 ! firm's 8reply0 tri$ to resurrect ! peps9 pancreat9 controv]sy4 ,?is also has no?+ to d ) ! effici5cy or h>mlessness ( sodium cacodylate4 ,9 ord] to dispose ( ! matt]1 h[ev]1 x may be po9t$ out t ! implications are entirely mislead+4 ,! "w :i* is quot$ aga9/ ! ,c\ncil 0 und]tak5 by ! ,c\ncil itself1 to cl>ify obscurities 9 ! old] data4 ,! outcome ( ^! new inve/igations %[$ ! ess5tial correctness ( ! d$uctions f ! old] "w1 namely1 t pancreat9 is de/roy$ by peps9-hydro*loric acid4 ,dr4 ,long's "w to :i* ! firm's reply evid5tly ref]s1 %[$ t "u favorable conditions1 namely1 :5 protect$ by an excess ( prote91 "s tryps9 may escape de/ruction 9 ! /oma*2 b x fully confirm$ ! orig9al conclusion t peps9 & pancreat9 mixtures z ord9>ily adm9i/]$ are practically wor?less 7,j4 ,h4 ,long1 ,j\r4 ,am]4 ,ph>maco4 ,assoc41 ,sept4 #ai1 #aiag74 ,z reg>ds ! editorial on intrav5\s !rapy1 a concession may be made ! ,new ,york ,intrav5\s ,laboratory3 intrav5\s injections are no long] q z 8impressive0 z 9 #aiaf1 b t does n alt] ! fact t !y %\ld be us$ only :5 a di/9ct advantage is to be ga9$4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,aug4 #b1 #aiai7 ,,hormotone ,,& ,,hormotone ,,)\t ,,po/-,,pituit>y ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry4 8,hormotone10 ( ! ,g4 ,w4 ,c>nrick ,company1 is adv]tis$ z 8,a plurigl&ul> tonic = a/h5ic conditions40 8,hormotone ,)\t ,po/-,pituit>y0 is recomm5d$ = use 89 neura/h5ic conditions associat$ ) high blood pressure40 ,^! prep>ations are sold 9 ! =m ( tablets = oral adm9i/ration4 ,! ,c\ncil decl>es ^! prep>ations inadmissible to ,new & ,non(ficial ,rem$ies because3 7#a7 ,_! composition is semisecret 7,rule #a72 7#b7 ! !rapeutic claims are unw>rant$ 7,rule #f72 7#c7 !y are sold "u names n descriptive ( _! composition b sugge/ive ( indiscrim9ate use z 8tonics0 7,rule #h72 7#d7 9 ! light ( our pres5t k ! r\t9e adm9i/ration ( polygl&ul> mixtures is irrational 7,rule #aj74 ,9 explanation ( ?is action1 ! ,c\ncil au?oriz$ publication ( ! report :i* appe>s bel[4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,ea* tablet ( 8,hormotone0 7,g4 ,w4 ,c>nrick ,co41 ,new ,york ,city7 is said to conta9 #a_/aj gra9 ( desiccat$ ?yroid & #a_/bj gra9 ( entire pituit>y1 toge!r ) ! hormones ( ! ov>y & te/es--! am\nts & ! =m 9 :i* ! latt] are suppos$ to be pres5t are n giv54 ,f ?is x w be se5 t ! only def9ite in=mation giv5 to ! m$ical pr(ession reg>d+ ! composition ( ,hormotone is t x is a weak ?yroid & a /ill weak] pituit>y prep>ation4 ,:at results c be anticipat$ f "o or two tablets ?ree times daily 7! recomm5d$ dose ( ,hormotone7 ea* conta9+ #a_/aj gra9 ( ?yroid & #a_/bj gra9 entire pituit>y8 ,su* doses ( ?yroid may1 ( c\rse1 h a b5eficial action 9 a limit$ numb] ( cases ( myx$ema & cret9ism4 ,an extract ( ! po/]ior lobe ( ! pituit>y 7,liquor ,hypophysis1 ,u4 ,s4 ,p41 = example7 w1 :5 inject$ subcutane\sly or intramuscul>ly1 h a pron\nc$ effect on ! p>turi5t ut]us2 its action on c]ta9 o!r =ms ( smoo? muscle w be mu* less c]ta94 ,b ! oral adm9i/ration 7= :i* ,hormotone is recomm5d$7 ( ! po/]ior lobe ( ! pituit>y has n be5 %[n to h any su* effect4 ,! use ( ! ant]ior lobe 9 doses ( #a to #d gra9s 7doses v _m times l>g] ?an ^? recomm5d$ = ! entire gl& 9 ,hormotone7 is 9 ! exp]im5tal /age & its only probable value seems to be 9 ^? cases ( kn[n gl& defici5cy4 ,z to ! o!r alleg$ +r$i5ts ( ,hormotone--hormones ( ! ov>y & te/es1 am\nts n /at$3 all physicians "k ! unc]ta9ties att5d+ ! use ( ov>ian prep>ations & ! s]i\s "q z to :e!r te/icul> extracts h any !rapeutic value4 ,:atev] may be ! physicians views z to ! probable !rapeutic value ( ^! organs1 ! fir/ ?+ he desires to "k is h[ mu* ( ! sub/ance he is giv+ & f :at "p ( ! gl& x is obta9$4 ,s mu* = ! facts2 yet ! physician is ask$ to jump f ?is region ( solid fact into a sea ( hypo!sis2 to believe t small am\nts ( ! well-kn[n drugs ?yroid & pituit>y1 plus an unkn[n am\nt ( unkn[n hormones ( ! te/es & ov>y are ( great value 9 conditions t 9 !mselves are (t5 purely hypo!tical4 ,he is ask$ to believe t ?is comb9ation has virtues 9 su* conditions z 8hyp(unction ( ! adr5al sy/em10 neura/h5ia1 ! 8fatigue syndrome10 am5orrhea1 dysm5orrhea1 8natural & artificial m5opause10 sexual neuroses1 cold extremities1 c>diac a/h5ia1 l[ blood pressure1 infantilism1 /]ility1 melan*olic conditions1 obesity1 anorexia1 anemia1 sl[ metabolism1 con/ipation1 psy*a/h5ia1 l[]$ virility & ! sexual neuroses ( ! unm>ri$1 hy/]ia foll[+ functional exhau/ion ( ! n]ve c5t]s1 frigidity1 etc41 etc41 especially if he guesses t ! tr\ble is due to a 8plurigl&ul> di/urbance10 8gl&ul> hyp(unction10 an 8adr5o-pituit>y defici5cy10 suboxidation1 etc4 ,! physician is invit$ to use ,hormotone because1 among o!r reasons1 ea* alleg$ con/itu5t is said to be 89 physiologic sympa?y & !rapeutic h>mony ) ! o!rs10 & fur!r1 because3 8,plurigl&ul> !rapy has ! endorsem5t ( high au?orities1 is bo? logical & effective & ,hormotone is a spl5did example ( x4 ,x w be se5 at its be/ :]e ! pati5t lacks snap & vim & vigor4 ,a/h5ic conditions necess>ily indicate hyp(unction ( ! adr5al sy/em 4440 etc4 8,! use ( gl& extracts 9 ! treatm5t ( aplasias ( ! plurigl&ul> sy/em has become an e/abli%$ !rapeutic measure ( miracul\s pot5cy 7,bay>d ,holmes3 ,! ,int]nal ,secretory ,gl&s1 ,lancet-,cl9ic1 ,sept4 #ai1 #aiad740 ,! ,g4 ,w4 ,c>nrick ,company also adv]tises a 8,hormotone ,)\t ,po/-,pituit>y10 ea* tablet ( :i* is said to conta9 #a_/aj gra9 desiccat$ ?yroid1 & to 8pres5t0 8hormone be>+ extracts ( ?yroid1 ant]ior pituit>y1 ov>y1 & te/es40 ,?is product is j z irrational z 8,hormotone40--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,aug4 #af1 #aiai7 ,,=maldehyde ,,loz5ges ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has vot$ ,hex-,iod9 7,daggett & ,mill] ,co41 ,inc41 ,provid5ce1 ,r4 ,i471 ,=mitol ,tablets 7,e4 ,l4 ,pat* ,co41 ,bo/on71 & ,c9-,u-,=m ,loz5ges 7,mc,kesson & ,robb9s1 ,new ,york ,city7 inadmissible to ,new & ,non(ficial ,rem$ies1 & au?oriz$ publication ( ! report :i* appe>s bel[4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,"s ye>s ago1 ! ,c\ncil publi%$ 7,! ,j\rnal ,a4 ,m4 ,a41 ,aug4 #bh1 #aiae1 p4 #haf7 a report on ,=mam9t1 a propriet>y m$ic9e widely exploit$ z a peculi> *emical comp\nd ( sug> ( milk & =maldehyde4 ,! =maldehyde 0 said to be lib]at$ sl[ly by ! action ( ! saliva1 & because ( ?is lib]ation ( =maldehyde1 ,=mam9t 0 claim$ to be a p[]ful g]micide4 ,extravagant claims 7 made = its curative & prophylactic effects4 ,! ,c\ncil f\nd t ! !rapeutic claims 7 grossly unw>rant$ & t its exploitation to ! public 0 a public dang]4 ,dur+ ! rec5t epidemic ( influ5za1 a v>iety ( tablets or loz5ges 7 adv]tis$1 & are /ill be+ adv]tis$1 hav+ =maldehyde1 9 "s =m or o!r1 z ! nucleus ar\nd :i* revolve ! !rapeutic claims4 ,9 "s cases1 ! adv]tis+ cle>ly indicates ! "* ( ! =maldehyde comp\nd t is claim$ to be pres5t2 9 o!rs ! /atem5ts are vague & indef9ite or mislead+4 ,x is h>dly necess>y to rem9d physicians t ! use ( tablets conta9+ hexame?yl5am9 or o!r =maldehyde comp\nds c nei!r cure respiratory infections1 nor ev5 conf] protection aga9/ su* infections4 ,to be effective1 =maldehyde w\ld ne$ to be suppli$ to ! entire respiratory tract cont9u\sly = "s "t or else 9 conc5trations t w\ld be di/9ctly irritant & damag+ to ! tissues4 ,saliva-dissolv$ tablets1 obvi\sly _c rea* ! nasal or tra*eal mucosae directly2 & ! application ( quickly act+ conc5trations ( =maldehyde is out ( ! "q4 ,?is altoge!r aside f ! fact t hexame?yl5am91 ! basis ( "s ( ^! tablets1 does n lib]ate =maldehyde 9 ! m\?1 & = ?is reason alone w\ld be q useless = ?is purpose6 7,see ,hanzlik & ,coll9s1 ,ar*ives ( ,int]nal ,m$ic9e1 ,novemb]1 #aiac47 ,an ineffici5t antiseptic is m ?an m]ely useless2 x is a m5ace to public safety1 9 t x t5ds to lead to ! neglect ( rational & effective protective measures4 ,x !re=e seems advisable = ! ,c\ncil aga9 to call ! att5tion ( physicians to ! subject4 ,accord+ly1 ?ree specim5s ( ^! products 7 pur*as$ & exam9$ 9 ! ,association's ,*emical ,laboratory4 ,hex-,iod9 ,hex-,iod9 7,hexame?yl5etetram9e & ,iodum7 ,loz5ges are manufactur$ by ,daggett & ,mill] ,company1 ,inc41 ,provid5ce1 ,r4 ,i4 ,!y weigh #ae-a_/b grs4 ea*1 are sweet5$ & are flavor$ ) m9t or m5?ol4 ,! package & circul>s d n conta9 a def9ite /atem5t ( composition4 ,! r indef9ite synonyms 8,hexame?4 & ,iod9e ,comp40 & 8,hexame?yl5etetram9e & ,iodum0 sugge/ t ! loz5ges conta9 hexame?yl5am9 & free iod94 ,! fur!r /atem5t t !y 8conta9 ! comb9$ m$ic9al antiseptic & prophylactic prop]ties ( ,hexame?yl5etetram9e & ,iodum0 is also r indef9ite4 ,! !rapeutic action claim$ = ! loz5ges1 h[ev]1 c\ld only be produc$ by free iod9 & by lib]at$ =maldehyde4 ,x is unnecess>y to discuss 9 detail ! extravagant claims made = ^! loz5ges4 ,! ineffici5cy ( hexame?yl5am9 has already be5 ref]r$ to2 ! limitations ( iod91 free or comb9$1 9 loz5ge =m1 ne$ n be discuss$ because ! exam9ation made 9 ! ,a4 ,m4 ,a4 ,*emical ,laboratory %[$ t ,hex-,iod9 loz5ges conta9$ no free iod91 & only traces ( comb9$ iod94 ,nei!r =maldehyde nor p>a=maldehyde 0 pres5t2 hexame?yl5am9 0 pres5t b1 ! loz5ges be+ neutral no =maldehyde is g5]at$ 9 contact ) wat] or ) ! alkal9e saliva4 ,?us ,hex-,iod9 is %[n to be wor?less = ! purpose = :i* x is adv]tis$4 ,( ! two important +r$i5ts said to be pres5t1 iod9 & hexame?yl5am91 only traces c\ld be f\nd ( ! =m] :ile ! latt]1 z has be5 %[n1 is incapable ( ex]t+ any effect :5 us$ z ! manufactur]s direct4 ,=mitol ,tablets ,^! tablets are prep>$ by ! ,e4 ,l4 ,pat* ,co41 ,bo/on4 ,ea* tablet weighs #ac-a_/b grs4 ,!y h ! odor ( ?ymol or m5?ol & an acid ta/e & reaction4 ,!y are1 accord+ to ! label3 8,= ! ?roat & m\?4 ,soo?+1 ,a/r+5t1 ,antiseptic4 ,rapidly de/roys g]ms ( infection1 prev5t+ & reliev+ sore ?roat & m\?40 ,9 a circul>1 x is /at$1 t "o ( ! qualities ( ,=mitol3 8444 is ! g5]ation ( =maldehyde :5 9 contact ) wat] or ! saliva40 8,besides g5]at+ =maldehyde1 ,=mitol1 ,pat* conta9s a/r+5t1 demulc5t & soo?+ +r$i5ts :i* r5d] ! comb9ation unusually effective40 ,a bact]iologic report is giv5 9 ?is circul> 9 :i* x is /at$ t1 9 #b-a_/b m9utes "o ,=mitol ,tablet r5d]$ /]ile a plate culture ( a 8*>act]i/ic ?roat micrococci40 ,! in/ructions are to dissolve a tablet 9 ! m\?1 sl[ly1 once an h\r or a half-tablet e half h\r4 ,! ,a4 ,m4 ,a4 ,*emical ,laboratory report$ t ,=mitol ,tablets conta9$ =maldehyde 7or p>a=maldehyde71 & ammonium comp\nd1 & "s hexame?yl5am94 ,x is probable t ! =maldehyde 7or p>a=maldehyde7 0 produc$ by ! decomposition ( hexame?yl5am9 orig9ally pres5t 9 ! tablets b decompos$ by long contact ) ! acid4#abh #abh ,! ,e4 ,l4 ,pat* ,company decl>es t 8no hexame?yl5am9e has ev] be5 us$ 9 ! manufacture ( ,=mitol tablets10 & t ammonium *loride & p>a=maldehyde are among ! +r$i5ts us$ 9 ! manufacture ( ^! tablets4 ,! hexame?yl5am9e pres5t 9 ! tablets1 !re=e1 mu/ h be5 produc$ by int]action ( ! p>a=maldehyde & ammonium *loride4 ,?is does n alt] ! laboratory f9d+s reg>d+ ! composition ( ! tablets1 namely1 t !y 8conta9 =maldehyde 7or p>a=maldehyde71 an ammonium comp\nd & "s hexame?yl5am9e40 ,^! tablets diff] f ,hex-,iod9 9 t !y really conta9 active =maldehyde &1 !re=e1 possibly produce antiseptic effect 9 te/-tube cultures4 ,! conditions 9 ! m\?1 h[ev]1 are v diff]5t f ^? 9 ! te/-tube1 s9ce 9 ! m\? ! =maldehyde w\ld be imm$iately 8b\nd0 or absorb$4 ,! claim$ abs5ce ( irritation indicates suffici5tly ! abs5ce ( effici5t quantities ( =maldehyde "u cl9ical conditions4 ,c9-,u-,=m ,loz5ges ,c9-,u-,=m ,loz5ges1 manufactur$ by ,mc,kesson & ,robb9s1 ,new ,york ,city1 are m>ket$ 9 bottles ( #bd = #be c5ts4 ,!y h a /rong odor ( c9namon1 weigh #ae-a_/b grs4 ea*1 & are acid 9 ta/e & reaction4 ,! label /ates t !y conta93 8,c9namon1 ,eucalyptus1 ,=maldehyde & ,m5?ol--all p[]ful g]micides aga9/ ,influ5zal bacilli1 b n injuri\s to ! sy/em 9 ?is palatable =m40 ,a circul> conta9s ! same /atem5t z to composition & claims fur!r t !y3 8444 help to prev5t ! infection ( ,spani% ,influ5za1 ,pneumonia1 ,grip ,colds & to gu>d aga9/ ,sore ,?roat1 ,tonsillitis1 ,ph>yngitis1 etc40 ,! ,a4 ,m4 ,a4 ,*emical ,laboratory report$ t ,c9-,u-,=m ,loz5ges conta9$ "s =maldehyde 7or p>a=maldehyde7 & no hexame?yl5am94 ,x is obvi\s t ! m\? & ?roat _c be 8dis9fect$0 by ^! loz5ges4 ,!y w\ld be totally ineffective aga9/ bact]ia t ent] ?r\gh ! nose2 !y _c prev5t influ5za1 pneumonia1 etc4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,oct4 #d1 #aiai7 ,,lavoris ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,lavoris 0 consid]$ by ! ,c\ncil 9 #aiac1 & its proprietors--! ,lavoris ,*emical ,company--7 advis$ t ! prep>ation 0 inadmissible to ,new & ,non(ficial ,rem$ies because ( conflict ) ,rules #a1 #d1 #f1 #h & #aj4 ,no report 0 publi%$ at t "t4 ,z ! prep>ation is /ill widely adv]tis$ to physicians1 ! ,c\ncil has aga9 exam9$ ,lavoris & au?oriz$ publication ( ! foll[+ report4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,9 rec5t ye>s ,lavoris has be5 widely adv]tis$ z 8,,! ,,ideal ,,oral ,,antiseptic10 p>ticul>ly to ! d5tal pr(ession4 ,a pr9t$ c>d s5t out by ! ,lavoris ,*emical ,company 9 #aiac read3 8,,lavoris1 ! ,pyorrhea ,rem$y4 ,! ,orig9al ,,z9c ,,*loride ,m\? ,wa%4 ,"o gra9 z9c to ea* ounce40 ,! c>d also gave a 8=mula0 to ! effect t ea* p9t ( ,lavoris conta9$3 ,z9c ,*loride #a4jdj ,resorc9 #j4ebj ,m5?ol #j4djj ,sac*>9 #j4aie ,=mal9 #j4aie ,ol4 ,cassia ,zeyl #j4ghj ,ol4 ,c>yophyl #j4aie ,adv]tisem5ts n[ appe>+ 9 m$ical j\rnals repeat ! old] 8=mula0 except t resorc9 is omitt$4 ,! =mula :ile seem+ly frank & op5 is 9 reality indef9ite & mislead+ 9 t no d5om9ation ( weight is giv5 = ! v>i\s con/itu5ts4 ,x is unc]ta91 = example1 if ! figures 9 ! =mula are int5d$ to repres5t gra9s1 grams or p]c5tages ( ! sev]al con/itu5ts4 ,9 view ( ! indef9ite /atem5t ( composition1 a *emical exam9ation ( ,lavoris 0 und]tak5 9 ! ,a4 ,m4 ,a4 ,*emical ,laboratory4 ,! report ( ! laboratory foll[s3 ,z9c4--,?is 0 det]m9$ electrolytically4 ,fifty c4c4 gave #j4jbf gm4 z9c & #ajj c4c4 gave #j4jeca gm4 z9c4 ,! av]age is #j4jebf gm4 z9c 9 #ajj c4c4 ,?is is equival5t to #j4aajb gm4 anhydr\s z9c *lorid 9 #ajj c4c4 ,*lorid4--,aft] decoloriz+ "s ( ,lavoris ) *lorid-free animal *>coal1 ! *lorid 0 det]m9$ by ! ,volh>d me?od4 ,tw5ty-five c4c4 ,lavoris requir$ #d4cbh c4c4 t5?-normal silv] nitrate solution equival5t to #j4jaece gm4 *lorid 7*loridion7 or #j4jfad gm4 9 #ajj c4c4 ,a second #be c4c4 ( ,lavoris requir$ #d4aab gm4 t5?-normal silv] nitrate solution equival5t to #j4jadeh gm4 *lorid 7*loridion7 or #j4jehcb gm4 9 #ajj c4c4 ,av]age is #j4jeihe gm4 ,?is is equival5t to #j4aaej gm4 z9c *lorid 9 #ajj c4c4 ,?is agrees closely ) ! =ego+ z9c det]m9ation4 ,resorc94--,! me?od ( ! ,u4 ,s4 ,ph>macopeia 0 us$4 ,! total brom9 absorption ( #be c4c4 ,lavoris 0 #c4fh c4c4 t5?-normal brom9 solution4 ,?is w\ld be equival5t to #j4jjfge gm4 resorc9 9 #be c4c4 or #j4jbgjj gm4 9 #ajj c4c4 ,9 a duplicate te/1 #be c4c4 ,lavoris requir$ #c4h c4c4 t5?-normal brom9 solution equival5t to #j4jjfig gm4 resorc9 or #j4jbghh gm4 9 #ajj c4c4 ,s9ce oil ( c9namon absorbs brom91 #ej c4c4 ( ,lavoris 0 boil$ until v little or no odor ( ! oil 0 not$1 keep+ ! volume ne>ly con/ant by add+ a little wat] f "t to "t1 & ! brom9 absorption !n tak54 ,9 "o exp]im5t1 #j4cf c4c4 ( t5?-normal brom9 solution 0 consum$1 & 9 a duplicate no brom9 0 absorb$4 ,?is %[s ! abs5ce ( resorc94 ,residue4--,on evaporat+ #be c4c4 ,lavoris on a /eam ba? & subsequ5t dry+ ( ! residue at #ajj ,c41 #j4jdee gm4 ( residue 0 obta9$4 ,?is is equival5t to #j4ahbj gm4 9 #ajj c4c4 ,sac*>94--,sac*>9 0 detect$ 9 ! residue & e!r-extract ( ! residue by its int5se sweet ta/e :5 a little sodium bic>bonate 0 add$ to x4 ,=maldehyd4--,?is c\ld be detect$ by ! ,j>rison te/4 ,! color 0 n v pron\nc$ & ! quantity ( =maldehyd 0 small4 ,oil ( ,c9namon4--,! odor & ta/e ( ,lavoris is *>act]i/ic ( c9namon4 ,m5?ol & ,oil ( ,cloves4--,! odor ( m5?ol & ( oil ( cloves c\ld n be detect$1 b no te/s 7 made to demon/rate _! pres5ce4 ,! analysis ?us indicates t ! ,lavoris ( today conta9s no resorc9 b does conta9 a small am\nt ( =maldehyd1 a little sac*>91 & oil ( c9namon 7m5?ol & oil ( cloves c\ld n be detect$ by ! odor1 b 7 n te/$ =74 ,! analysis %[$ t ! pr9cipal con/itu5t ( ,lavoris is z9c *lorid1 ( :i* !re is ab\t #j4a gm4 p] #ajj c4c4 7ab\t #a_/b gra9 to ! ounce74 ,! am\nt ( z9c *lorid giv5 9 ! publi%$ =mula1 i4 e41 #a4jd1 is mean+less because ! unit ( weight or measure is n giv52 fur!rmore1 ! analysis %[s t x is inaccurate = any unit ( weight t might be assum$ f ! publi%$ figures4 ,s9ce ! am\nt ( ! mo/ active m$ic9al +r$i5t is bo? indef9ite & inaccurate1 ! composition ( ! prep>ation is ess5tially secret4 ,lavoris is indirectly adv]tis$ to ! public by hav+ includ$ 9 ! package a circul> giv+ a li/ ( diseases = :i* ! prep>ation 0 recomm5d$4 ,! comb9ation ( z9c *lorid1 =maldehyd & oil ( c9namon 7assum+ ! m5?ol & oil ( cloves to be pres5t z flavors7 9 a mixture is irrational & likely to lead its us]s to ascribe a false & exagg]at$ value to ! prep>ation4 ,! "n is objectionable 9 t x does n indicate ! composition ( ! pot5t +r$i5ts ( ! mixture1 b in/ead sugge/s its use z a m\? wa%4 ,f a /&po9t ( public safety1 ! mo/ s]i\s objection to ,lavoris1 h[ev]1 lies 9 ! _m unw>rant$ !rapeutic claims & sugge/ions4 ,x is g5]ally held t z9c *lorid solutions :i* possess a /r5g? ( f #a to #bjj up to #a to #ejj ex]cise a weak antiseptic action4 ,! /r5g? ( z9c *lorid 9 ,lavoris is approximately #a to #a1jjj4 ,! directions = its use recomm5d t ,lavoris %\ld be dilut$4 ,a dilution ( #a to #d is recomm5d$ = a v>iety ( m\? conditions :ile = cy/itis irrigations & z a vag9al d\*e1 x is recomm5d$ t "o tablespoonful be add$ to a qu>t ( w>m wat] or salt solution4 ,! /r5g? ( z9c *lorid 9 ! la/ sugge/$ dilution w\ld approximate #a to #fd1jjj4 ,x is evid5t t no antiseptic action c\ld be expect$ f su* dilutions4 ,! recomm5dation t dilut$ ,lavoris be us$ = ! treatm5t ( coryza1 nasal cat>rh1 hay fev]1 inflam$ eyes1 hemorrhoids & leucorrhea is objectionable & irrational4 ,especially dang]\s is ! recomm5dation t memb]s ( a family expos$ to diph!ria or sc>let fev] %\ld use ,lavoris freely z a prev5tive4 ,su* recomm5dations c b give a false s5se ( security & lead to ! neglect ( prov$ me?ods = prev5t+ ! spread ( ^! diseases4 ,equally unw>rant$ is ! recomm5dation t 9 gonorrhea "o teaspoonful ( ,lavoris to eight ( w>m wat] be us$ ) a blunt end syr+e4 ,! use ( ,lavoris z recomm5d$ w\ld n only prove valueless 9 _m in/ances b might lead to s]i\s consequ5ces because really valuable me?ods ( prev5tion or treatm5t might be neglect$4 ,= ^! reasons ! prep>ation is 9 conflict ) ,rule #f4 ,! ,c\ncil decl>$ ,lavoris ineligible = ,new & ,non(ficial ,rem$ies4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #a1 #aiai7 ,,m$9al ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has au?oriz$ publication ( ! foll[+ report on ,m$9al 7,s*]+ & ,glatz1 ,inc474 ,w4 ,a4 ,puckn]1 ,secret>y4 ,m$9al is a propriet>y "n appli$ to b>bital sodium 7sodium die?ylb>biturate7 ! sodium salt ( b>bital 7die?ylb>bituric acid74 ,! latt] 0 fir/ introduc$ z ,v]onal4 ,m$9al 0 delet$ f ,new & ,non(ficial ,rem$ies 9 #aiaf because ! adv]tis+ issu$ by ,s*]+ & ,glatz 7:o !n act$ z ag5ts = ,*emis*e ,fabrik auf ,acti5 vorm4 ,e4 ,s*]+1 ! ,g]man manufactur]7 conta9$ mislead+ & unw>rant$ !rapeutic claims4 ,! ,c\ncil did n publi% its report because by ! "t ! report 0 ready = publication ! product 0 practically (f ! ,am]ican m>ket1 & x 0 hop$ t :5 ,m$9al aga9 became available1 ,s*]+ & ,glatz w\ld revise ! claims & ?us p]mit its reacceptance4 ,m$9al1 said to be manufactur$ 9 ! ,unit$ ,/ates1 is n[ m>ket$ by ,s*]+ & ,glatz1 ,inc4 ,9 ,octob]1 #aiah1 ! firm s5t to ! ,c\ncil a typewritt5 copy ( a propos$ circul> = ,m$9al4 ,! firm 0 in=m$ t ?is leaflet 0 subject to ! objections t _h be5 rais$ :5 ,m$9al 0 delet$ f ,new & ,non(ficial ,rem$ies4 ,9 ,april1 #aiai1 ! firm submitt$ a pr9t$ circul> :i* x 0 s5d+ out4 ,?is conta9$ num]\s mislead+ /atem5ts1 among !m1 ^!3 8,,m$9al removes its ,die?ylb>bituric acid "o objectionable feature--insuffici5t solubility--& ?us fulfills ! ?ree pr]equisites ( a truly rational hypnotic3 ,quick absorption1 insur+ prompt action1 rapid & complete excretion1 af=d+ protection f cumulative toxic aft] effects1 & ! *oice ( rectal & subcutane\s adm9i/ration40 ,!re is no ju/ification = ! claim t die?ylb>bituric acid 7b>bital7 has only "o objectionable feature & t a m9or matt] ( 8insuffici5t solubility40 ,! ,c\ncil has call$ ! att5tion ( ,s*]+ & ,glatz1 ,inc41 to ! fact t ! diff]5ce 9 ! "t ( absorption betwe5 ,m$9al 7b>bital sodium7 & b>bital is1 at ! mo/1 b "o ( m9utes & t !re is no evid5ce t ,m$9al is excret$ m rapidly ?an b>bital4 ,h5ce ! claims t ! dang] ( toxic side-actions & t cumulative aft]-effects are avoid$ 9 ?is product1 are :olly unw>rant$4 ,x is also claim$1 & ! claim is unsupport$ by satisfactory evid5ce1 t ,m$9al is useful 9 ! insomnia ( tub]culosis 9 :i* condition x is said to h a d\ble advantage ow+ to its favorable effects on ! night-sweats4 ,x is claim$ t ,m$9al is us$ 9 ! )drawal treatm5t ( morph9 addiction ) great success2 !re is no evid5ce t ,m$9al has any special usefulness 9 ?is treatm5t ( ! morph9 habit4 ,x is claim$ fur!r t success has be5 report$ ) ,m$9al 9 ! treatm5t ( :oop+ c\gh4 ,! ,c\ncil kn[s ( no satisfactory evid5ce to %[ t ,m$9al is ( special value 9 :oop+ c\gh2 on ! contr>y1 x is capable ( do+ a great deal ( h>m4 ,! recomm5dations t ,m$9al be us$ = ! control ( labor pa9s & 9 acute neuralgic pa9s t resi/ o!r =ms ( treatm5t are :olly unw>rant$ z ! value ( ! drug 9 su* conditions is inh]5tly improbable & until satisfactory evid5ce 9 support ( !m is =?com+1 mu/ be deem$ mislead+4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #ae1 #aiai7 ,,omission ,,( ,,cot>n9 ,,salts 7,,/yptic9 ,,& ,,/yptol7 ,,f ,n4 ,n4 ,r4 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has au?oriz$ publication ( ! foll[+ report4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,salts ( ! base cot>n9 h be5 us$ z local & sy/emic hemo/atics4 ,! hydro*lorid 0 fir/ introduc$ z 8,/yptic910 & is n[ 9 ! ph>macopeia z cot>n9 hydro*lorid 7,cot>n9ae ,hydro*loridum1 ,u4 ,s4 ,p474 ,! ph?allic acid salt ( cot>n9--cot>n9 ph?allate--0 introduc$ z 8,/yptol40 ,bo? ,/yptic9 & ,/yptol 7 admitt$ to ,new & ,non(ficial ,rem$ies4 ,9 #aiah ! ,c\ncil vot$ to omit ,/yptic9 because ! =m] ,am]ican ag5ts 7 no long] (f]+ x = sale4 ,/yptol 0 reta9$ & is describ$ 9 ,n4 ,n4 ,r41 #aiai4 ,z 0 po9t$ out 9 ! description 7,n4 ,n4 ,r41 #aiah71 ! evid5ce = ! usefulness ( ! cot>n9 salts has be5 contradictory & unsatisfactory2 b s9ce ! available data aga9/ ! effici5cy 7 at lea/ equally unreliable1 ! ,c\ncil deem$ x be/ to reta9 !m 9 ,n4 ,n4 ,r4 p5d+ a ?or\gh inve/igation ( ! subject4 ,?is 0 und]tak5 by ,p4 ,j4 ,hanzlik1 at ! sugge/ion ( ! ,!rapeutic ,rese>* ,committee ( ! ,c\ncil4 ,a reliable judgm5t ( hemo/atic effici5cy c be =m$ only on a basis ( /rictly controll$ conditions1 :i* c be/ be furni%$ 9 ! laboratory4 ,hanzlik repeat$ ! pr9cipal exp]im5ts publi%$ by previ\s inve/igators1 & appli$ a numb] ( new or improv$ me?ods4 ,! results 7publi%$ 9 ! ,j\rnal ( ,ph>macology & ,exp]im5tal ,!rapeutics #aj3ebc1 #aiah2 #ab3ga1 #aiai7 %[ ! foll[+3 ,direct ,application to ,w\nds4--,! widely quot$ results ( ! gynecologi/ ,k4 ,abel1 on ! footpad ( cats1 7 f\nd to be q unreliable4 ,:5 ! exp]im5t is prop]ly controll$1 ! results are ei!r negative or ! ble$+ may be increas$4 ,quantitative exp]im5ts on w\nds ( ! footpad ( dogs %[$ t cot>n9 inv>iably increas$ ! ble$+4 ,equally negative or unfavorable results 7 obta9$ ) w\nds to ! comb ( roo/]s1 & to ! liv] & sple54 ,direct ,action on ,vessels4--,! results ( p]fusion exp]im5ts 7 v>iable1 b1 9 g5]al1 %[$ a vasodilation action in/ead ( con/riction4 ,?is holds true also ( ! ut]9e vessels4 ,! vessels 9 ! liv+ animal 7rabbit's e>7 7 also unaffect$4 ,sy/emic ,adm9i/ration4--,! ble$+ f an irrigat$ w\nd 0 n modifi$ directly by intrav5\s injection ( cot>n9 salts1 b v>i$ m]ely ) ! /ate ( ! blood pressure4 ,! evid5ce = ! ineffici5cy ( cot>n9 salts z hemo/atics seem$ s conclusive z to w>rant ! ,c\ncil 9 resc9d+ ! acceptance ( ,/yptol1 & direct+ ! omission ( ! g5]al article on cot>n9 salts & ! description ( ,/yptol f ,new & ,non(ficial ,rem$ies4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #bb1 #aiai7 ,,micajah',s ,,waf]s ,,& ,,micajah',s ,,suppositories ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry 8,micajah's ,m$icat$ ,waf]s0 & 8,micajah's ,suppositories10 sold by ,micajah ,co41 ,w>r51 ,pa41 are decl>$ inadmissible to 8,new & ,non(ficial ,rem$ies0 because 7#a7 _! composition is ess5tially secret 7,rule #a72 7#b7 "n ( nei!r ( ^! mixtures is indicative ( its composition 7,rule #h72 7#c7 ( exagg]at$ & unw>rant$ !rapeutic claims 7,rule #f71 & 7#d7 ! !rapeutic advice :i* accompanies ! trade packages con/itutes an indirect adv]tisem5t to ! public 7,rule #d74 ,w4 ,a4 ,puckn]1 ,secret>y4 ,micajah's ,m$icat$ ,waf]s 7=m]ly call$ 8,micajah's ,m$icat$ ,ut]9e ,waf]s07 7 analyz$ 9 ! ,a4 ,m4 ,a4 ,*emical ,laboratory 9 #aiaj4 ,!y 7 f\nd to consi/ ess5tially ( dri$ 78burnt07 alum1 boric acid & borax1 9 approximately ! foll[+ proportions3 ,alum1 dri$ #ei4hf p] c5t4 ,borax1 dri$ #ae4fb p] c5t4 ,boric acid #e4fg p] c5t4 ,wat] ( hydration #ah4he p] c5t4 ,!re are a numb] ( drugs t are m or less effective 9 ! treatm5t ( local lesions ( muc\s membranes & ! sk94 ,!y are class$ z a/r+5ts4 ,among ^! are includ$ alum1 borax & boric acid4 ,e physician has us$ !m4 ,to say t a waf] consi/s ( alum1 borax & boric acid inspires b little awe4 ,b !re is some?+ mu* m my/]i\s & impressive 9 decl>+ t a waf] 8consi/s ( an a/r+5t & antiseptic base1 9 :i* are incorporat$ c]ta9 m$icam5ts :i* bo? locally & aft] absorption1 contribute to ! a/r+5t1 antiphlogi/ic1 depletive1 soo?+ & heal+ action ( ! product40 ,?is gives ! impression t "s p[]ful & almo/ incompreh5sible factors are at "w4 ,yet1 aft] all is said & done1 ! sub/ances conta9$ 9 ,micajah's ,m$icat$ ,waf]s are j ! homely old alum1 boric acid & borax4 ,9 addition to 8,micajah's ,m$icat$ ,waf]s10 ,micajah ,co4 also put out 8,micajah's ,suppositories = ,hemorrhoids40 ,^! h be5 exam9$ 9 ! ,a4 ,m4 ,a4 ,*emical ,laboratory &1 l ! 8,m$icat$ ,waf]s0 h be5 f\nd to conta9 alum1 boric acid & borax--& ^! sub/ances practically alone--incorporat$ 9 cocoa butt]4 ,! company claims t 8to ^! h be5 add$ ,ammonii ,i*?yosulphonate1 ,balsam ( ,p]u1 ,ext4 ,belladonae40 ,! ,a4 ,m4 ,a4 *emi/s report1 h[ev]1 t if extract ( belladonna is pres5t at all x is 9 am\nts too small to be detect$ by ! me?od commonly employ$ 9 ! *emical exam9ation ( alkaloidal drugs4 ,! *emi/s report fur!r t :ile ammonium i*?yosulphonate & balsam ( ,p]u bo? h a decid$ odor & are d>k 9 color1 ! suppositories h b little color & ! odor ( ! cocoa butt] t =ms _! base is n cov]$ by ^! drugs2 obvi\sly1 !re=e1 if ammonium i*?yosulphonate & balsam ( ,p]u are pres5t at all x is 9 am\nts utt]ly insuffici5t to ex]t any !rapeutic effect4 ,x w\ld be h>d to f9d bett] examples ( mis*iev\s propriet>y m$ic9es ?an ^! two products ( ! ,micajah ,company4 8,tw9s ( ,effici5cy10 !y are call$ 9 an adv]tis+ pamphlet4 ,! composition is n /at$4 ,a physician us+ ! 8tw9s0 does s absolutely 9 ! d>k4 ,to him !y are secret prep>ations4 ,he is enc\rag$ to use !m 9 a great v>iety ( conditions 9 :i* o!r drugs are mu* m useful4 ,inevitably1 physicians us+ !m w be likely to ov]look1 or pass ov]1 new gr[?s1 specific infections & diseases t require radical rem$ial measures4 ,9 addition to mislead+ & exagg]at$ claims1 !re is a ref]5ce to a report f ! usual 8well-kn[n & reliable bact]iological laboratory40 ,! exc]pts publi%$ f ?is report ( an unnam$ laboratory are suffici5tly vague to incrim9ate no "o4 ,f "t to "t x is wor? :ile to emphasize facts reg>d+ propriet>y m$ic9es t :ile obvi\s are sometimes =gott54 ,= ?is reason att5tion is direct$ to ,micajah's ,ut]9e ,waf]s & ,micajah's ,suppositories4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #bi1 #aiai7 ,,alkali?ia ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,alkali?ia 0 introduc$ at a "t :5 x 0 believ$ t ! adm9i/ration ( li?ium salts s]v$ to remove uric acid f ! sy/em4 ,! product 0 consid]$ by ! ,c\ncil 9 #aijf1 & f\nd ineligible = ,new & ,non(ficial ,rem$ies4 ,no report1 h[ev]1 0 publi%$ at t "t4 ,because ( inquiries receiv$1 ! ,c\ncil exam9$ ! curr5t claims = ,alkali?ia1 & au?oriz$ publication ( ! report :i* appe>s bel[4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,keasbey & ,mattison ,company's ,eff]vesc5t ,alkali?ia is sold ) ! foll[+ /atem5t ( composition3 8,ea* dose or heap+ teaspoonful conta9s #a gra9 ( ,caffe9e1 #aj gra9s ea* ( ,bi-c>bonates ( soda & pota%1 & #e gra9s ( ,c>bonate ( ,li?ia40 ,! ,a4 ,m4 ,a4 ,*emical ,laboratory reports t ,alkali?ia is an eff]vesc5t mixture :i* conta9s alkal9e c>bonates & bic>bonates toge!r ) caffe91 free t>t>ic acid & free citric acid4 ,! major portion ( ! alkali c>bonates & bic>bonates is conv]t$ into citrates & t>trates :5 ! prep>ation is dissolv$ 9 wat]--z is done be=e x is tak54 ,an excess ( alkali is pres5t1 h[ev]1 z ! solution has an alkal9e reaction4 ,ea* 8heap+ teaspoonful0 7:i* 0 f\nd to be ab\t #d4he ,gm47 conta9s ab\t #j4jdd ,gm4 ( caffe9 7! manufactur]s claim #j4jfdh ,gm4 p] heap+ teaspoonful74 ,z tak51 ,alkali?ia1 !re=e1 repres5ts caffe9 9 a solution ( alkali t>trate1 citrate & bic>bonate conta9+ free c>bonic acid4 ,if x is assum$ t all ( ! t>trate & citrate 9 ,alkali?ia is conv]t$ into c>bonate 9 ! organism1 a 8heap+ teaspoonful0 ( ,alkali?ia w\ld repres5t ab\t #b4i ,gm4 ( sodium bic>bonate4 ,?is assumption is1 h[ev]1 n correct1 = x is kn[n t t>trates are n completely conv]t$ into c>bonates 9 ! organism4 ,accord+ to ! label on ! bottle1 ?is mixture ( caffe9 & alkali salts is 8a common s5se rem$y = ! relief & treatm5t ( conditions dep5d5t ^u p]v]t$ metabolism z manife/$ by neuralgic1 rheumatic1 c>diac & r5al symptoms40 ,wrapp$ ) a trade package is a circul> 9 :i* is discuss$ ! 8uric acid dia!sis0 z 8a cause ( ,rheumatism 9 its v>i\s =ms1 ,calculus1 ,gravel & ,inflammation ( ! ,bladd] & ,kidneys1 ,a/hma1 ,hay ,fev]1 ,cat>rh1 ,qu9sy & ,bron*itis1 ,eczema1 ,hives1 ,it*+ & ,burn+ ( ! ,sk91 ,palpitation ( ! ,he>t & ,cold ,h&s & ,feet1 ,dizz9ess1 ,m5tal ,depression1 ,melan*olia1 ,neuralgia1 ,*orea1 ,hy/]ia1 ,numbness & a great v>iety ( purely n]v\s symptoms40 ,! argum5ts = ! use ( ,alkali?ia z 8a safe & sci5tific treatm5t = ! uric acid dia!sis0 f\nd 9 ! circul> con/itute an indirect appeal to ! laity 7conflict ) ,rule #d74 ,9 ! circul> matt] s5t direct to ! physicians1 ,keasbey & ,mattison claim t 9 rheumatism1 ,alkali?ia is prescrib$ by ! m$ical pr(ession m (t5 ?an any o!r rem$y4 ,! claim is made t1 8,9 five m9utes ! ur9e w be discoloriz$ & analysis w %[ x to be load$ ) urates40 ,! manufactur]s fur!r ass]t3 8,y c *ange ! "* ( ! ur9>y secretion 9 a few m9utes completely0 by ,alkali?ia1 & 8,9 n9e cases out ( t51 :5 ! doctor prescribes #8,alkali?ia' 8 pati5t greatly improves1 or gets well40 ,! firm advises t 8,r5al ,insuffici5cy0 be det]m9$ by ! old me?od ( multiply+ ! ounces ( ur9e 9 tw5ty-f\r h\rs by ! la/ two numb]s ( ! specific gravity1 add+ #aj1 :i* gives ! numb] ( gra9s ( solids excret$ 9 ! tw5ty-f\r h\rs4 ,if ?is is l[1 no matt] :at ! cause1 !y advise ,alkali?ia1 8t ideal elim9ant40 ,! ,c\ncil decl>$ ,alkali?ia inadmissible to ,new & ,non(ficial ,rem$ies because ! claims made on ! label & ! circul> accompany+ ! trade package lead ! public to its detrim5t to dep5d on ?is prep>ation 7,rule #d72 & because ! !rapeutic claims are unw>rant$ 7,rule #f74--7;,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiai1 p4 #fe7 ,,arhov9 ,,omitt$ ,,f ,n4 ,n4 ,r4 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,arhov9 is a solution ( deph5ylam9e1 ?ymol b5zoate & e?yl b5zoate1 m>ket$ by ,s*]+ & ,glatz1 ,inc4 ,x 0 omitt$ f ,new & ,non(ficial ,rem$ies because ! !rapeutic claims made = ! prep>ation 7 unw>rant$ & because ! firm _h refus$ to discont9ue ! di/ribution ( ! adv]tis+ :i* conta9$ ! objectionable claims prior to ,jan4 #a1 #aiai4 ,:5 ! report :i* appe>s bel[ expla9+ ! dismissal 0 submitt$ to ,s*]+ & ,glatz1 ,inc41 ! firm aga9 promis$ a revision ( its adv]tis+1 b refus$ discont9uance ( ! objectionable circul> be=e ,jan4 #a1 #aibj4 ,s9ce ,arhov9 is /ill m>ket$ ) unw>rant$ !rapeutic claims1 ! ,c\ncil has au?oriz$ publication ( ?is report4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,! att5tion ( ! firm ,s*]+ & ,glatz1 ,inc41 0 call$ to mislead+ /atem5ts 9 its booklet = ,arhov9 9 #aiae1 & 9 #aiah ! firm 0 in=m$ t unless ! mislead+ /atem5ts 7 )drawn be=e ,jan4 #a1 #aiai1 ,arhov9 w\ld be omitt$ f ,new & ,non(ficial ,rem$ies4 ,! foll[+ quotations are tak5 f ! circul> 9 "q1 & illu/rate ! "* ( ! claims to :i* objection 0 made3 8,/rik+ also is ! antiphlogi/ic & ane/hetic effect ( ,arhov9 on ! inflam$ mucosae1 an effect :i*1 z all au?orities agree1 is f> great] ?an t ( all o!r int]nal anti-gonorrheaics40 8,"u its influ5ce vesical & pro/atic complications1 gonorrheal ar?ritis1 endoc>ditis1 etc41 are r>ely incurr$40 ,ref]5ces to ! indexes ( lead+ textbooks1 includ+ ^? ( ,mey] & ,gottlieb1 ,cu%ny1 ,sollman & ,ba/$o1 fails to %[ t ,arhov9 is s mu* z m5tion$ by ^? au?ors2 h5ce1 x is obvi\sly false to /ate1 z is done 9 ! fir/ ( ! quotations above1 t all au?ors agree conc]n+ ! /rik+ effects ( ,arhov94 ,_m ( ! /atem5ts are objectionable by reason ( ! actions impli$1 r ?an /at$ directly4 ,! foll[+ are examples3 8,arhov9 9 ,gonorrheal ,infections ( ! ,male ,g5ito-,ur9>y ,organs4 ,ant]ior ,ure?ritis4 ,?is is ! class ( cases 9 :i* ! mo/ favorable results f ,arhov9 h be5 report$40 8,po/]ior ,ure?ritis4 8,"h also ! /rik+ effects f ,arhov9 m$ication1 bo? 9 acute & *ronic cases1 are rapid decrease ( dis*>ge1 disappe>ance ( gonococci f ! secretion1 & cessation ( subjective difficulties1 su* z /rangury40 ,:ile ! firm did n agree to )draw ! objectionable adv]tis+ be=e ,jan4 #a1 #aiai1 :i* made necess>y ! omission ( ,arhov9 f ,new & ,non(ficial ,rem$ies1 #aiai1 x did submit a propos$ fold] 9 :i* ! mo/ objectionable ( ! claims are /ill made4 ,! foll[+ /atem5t1 :i* 0 9 ! propos$ 8fold]0 & is includ$ 9 an adv]tis+ pamphlet s5t out dur+ #aiai1 s]ves to illu/rate ^? po9ts3 8,its action is ?ree-fold3 8,/rong antiseptic & bact]icidal effect ^u ! ure?ral & vesical mucosae1 highly conducive to %ort5+ & palliation ( ! acute disease c\rse40 ,no evid5ce has be5 pres5t$ t ,arhov9 is capable ( de/roy+ ! gonococcus 9 ! ure?ra1 & consequ5tly1 ! ,c\ncil decl>$ ! recomm5dation = ! use ( ,arhov9 9 ! treatm5t ( gonorrhea1 by means ( claims su* z ^? j cit$1 is bo? mislead+ & dang]\s4--7,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiai1 p4 #ff7 ,,*loron1 ,,*lorax ,,& ,,numb] 8#c0 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! report :i* appe>s bel[ 0 s5t to ! ,*lor9e ,products ,company1 ,inc41 ,may #ad1 #aiai4 ,9 reply to an inquiry s5t ! ,*lor9e ,products ,company1 ,july #h1 ! company wrote t x c\ld s5d no reply because ! m$ical director 0 /ill 9 ,france4 ,h[ev]1 ,*loron & ,*lorax are be+ adv]tis$ 9 m$ical j\rnals2 also ess5tially ! same adv]tis+ z t discuss$ 9 ! report 0 rec5tly receiv$ by a physician f ! ,*lor9e ,products ,company4 ,! prec$+ facts hav+ be5 report$ to ! ,c\ncil1 publication ( ! report 0 au?oriz$4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,*loron1 ,*lorax & ,numb] 8#c0 are prep>ations ( ess5tially simil> composition put out by ! ,*lor9e ,products ,company1 ,inc41 ,new ,york4 ,*loron ,*loron1 accord+ to ! label1 is 8,a /able ,,*lor9e rem$y = ! r$uction ( inflammation1 relief ( pa9 & = all w\nds1 burns1 scalds & e description ( sores except canc] & lupus40 ,its composition is giv5 z3 8,free *lor9e1 #j4bjj p] c5t42 calcium *loride1 #j4aij p] c5t42 m]cur\s *loride1 #j4jcj p] c5t42 li?ium *loride1 #j4jce p] c5t42 calcium hydrate1 #j4jaj p] c5t42 wat] to #ajj p>ts40 ,! ,c\ncil ask$ ! manufactur]s = fur!r in=mation 9 reg>d to ! composition or prep>ation ( ,*loron & receiv$ ?is reply3 8,*lor9e gas is prep>$ 9 ! usual way & purifi$ & pass$ into wat] until a saturat$ solution is made4 8,wat] to ! ext5t ( ?ree times ! volume ( ! *lor9e solution is us$ to dissolve ! necess>y am\nt ( calcium *loride1 & ! two solutions are mix$4 8,! necess>y am\nts ( ,li?ium & ,m]cur\s ,*loride are !n intimately mix$ & made into solution4 ,?is solution is !n add$ to ! above & ! :ole is agitat$ = "s m9utes40 ,a specim5 ( ,*loron 0 exam9$ 9 ! ,a4 ,m4 ,a4 ,*emical laboratory & ! *emi/s report$3 ,qualitatively ! pres5ce ( ! foll[+ con/itu5ts 0 confirm$3 calcium1 m]cury1 li?ium1 *lorid1 free *lor94 ,! solution 0 alkal9e4 ,( c\rse1 ! decl>ation t ,*loron conta9s m]cur\s *lorid 7calomel7 is obvi\sly incorrect1 z m]cur\s *lorid _c exi/ 9 a solution conta9+ active 7free7 *lor91 b is oxidiz$ to m]curic *lorid 7corrosive sublimate74 ,z ! solution 0 alkal9e 9 reaction1 x seem$ unlikely t all ! active *lor9 0 pres5t 9 ! free /ate1 z decl>$ on ! label4 ,quantitative det]m9ation ( free *lor9 & ( total active 78available07 *lor9 gave3 free *lor91 #j4jcf gm4 p] hundr$ c4c42 total 8available0 *lor91 #j4ccj gm4 p] hundr$ c4c41 or #afe p] c5t4 ( ! claim$ am\nt4 ,a comp>ison ( ! in=mation s5t to ! ,c\ncil ) ! analytic f9d+s leads to ! conclusion t ,*loron is n ( reliable composition4 ,z evid5ce ( ! !rapeutic value ( ,*loron1 ! foll[+ 8case reports0 7 submitt$3 8,9 a case ( second degree burn involv+ ! mo/ ( "o leg f ! middle ( ! calf d[n1 ,,*loron 0 ! only dress+ us$4 ,! burn 0 a bad "o & ! pati5t 9 a rund[n anaemic condition1 at no "t 0 !re any appe>ance ( pus1 ! surface look$ clean & bright & ! heal+ 0 accompli%$ ) practically no sc> :atev]4 ,! burn 0 kept wet ) ! solution by h\rly applications day & night4 ,! sk9 :i* has gr[n on ! w\nd is cle>1 heal?y & firm4 ,9 ano!r case ( ,v>icose ve9s ( long /&+1 ! result 0 surpris+4 ,! pati5t told ( two ye>s vibrat+ f ,hospital to ,hospital & gett+ no real relief4 ,ea* leg _h l>ge op5 runn+ sores1 ! only dress+ us$ 0 wet compresses ( ?is solution4 ,! pus disappe>$ at once1 ! w\nd began to cicatrise f ! edges & 9 two weeks ! man 0 dis*>g$ f ! hospital practically cur$40 8,,*loron 0 rec5tly tri$ at ! ---- & ---- ,hospital on cases pres5t+ ulc]s & o!r sores :i* did n readily yield to o!r me?ods1 ) good results1 9 fact 7 ( an indol5t type4 ,9 ^! cases ,,*loron prov$ v valuable40 8,i h us$ ,,*loron on a s]ies ( cases 7surgical7 pres5t+ pus foci & ,i h f\nd ! application v b5eficial & heal+1 ! pus e>ly disappe>+4 ,9 cases ( ,o/eomyelitis1 ,suppurat+ ,ar?ritis1 ,cellulitis & ,*ronic ,ulc]s1 ,,*loron is p>ticul>ly valuable1 its good effects quickly obs]v$ & ! "t ( re/oration to heal? %ort5$40 ,9 ! fir/ case report1 !re is no evid5ce t ,*loron is m effici5t 9 ! treatm5t ( burns ?an any o!r commonly us$ proc$ure might h be54 ,9 ! case ( ! v>icose ulc]s1 :ile !re 0 "s app>5t b5efit f ,*loron1 no cr$it is giv5 to re/ & ! g5]al treatm5t :i* is kn[n to be important 9 ! treatm5t ( su* conditions4 ,! evid5ce 9 ! o!r case reports is q inconclusive4 ,consid]ation ( ! 8case reports0 leads to ! conclusion t cl9ical evid5ce = ! value ( ,*loron is lack+4 ,att5tion %\ld be call$ to ! fact t ! am\nt ( active *lor91 claim$ to be pres5t 9 ,*loron z well z ! am\nt f\nd by ! association laboratory1 is less ?an t consid]$ effective by ,dak91 ,dunham & o!rs2 seem+ly 9 prep>+ ,*loron no att5tion has be5 paid to ! degree ( alkal9ity1 yet ! importance ( ?is factor is n[ g5]ally recogniz$4 ,*loron fails to comply ) ! requirem5ts = surgical solution ( *lor9at$ soda 7,n4 ,n4 ,r41 #aiai1 p4 #acc71 yet ! manufactur]s make free use ( ! text ( ,dak9 & ,dunham's ,h&book ( ,antiseptics 9 _! adv]tis+ pamphlet4 ,?us3 ,f ! ,*loron pamphlet3 8,?is ideal antiseptic effects complete /]ilization )9 its sph]e ( action )\t caus+ any damage to ! cells or tissues4 ,an important me?od ( judg+ ! injuri\s action ( antiseptics is to inve/igate _! effects on ! leucocytes4 ,f exp]im5ts 9 vitro by ,p>ry ,morgan & 9 vivo by ,col4 ,c4 ,j4 ,bond ) ! /r5g? ( antiseptics commonly us$ 9 surg]y1 x has be5 f\nd t ,*lor9e antiseptics & m]cury salts h little effect on phagocytosis 9 comp>ison ) o!r g]micides4 ,! activity ( ! leucocytes f w\nds :i* h rec5tly be5 treat$ ) ,,*loron may be demon/rat$ exp]im5tally40 8,9 addition to its antiseptic action ,,*loron is a /rong oxidiz+ ag5t & deodorant & possesses to a m>k$ degree ! prop]ty ( decompos+ tox9s4 ,9 ?is connection x is int]e/+ & p]t95t to note t ,dean1 by ! regulat$ action ( hypo*lor\s acid1 has prep>$ a nontoxic dys5t]y vacc9e & x is n[ a common obs]vation t ! free use ( ,,*loron may r$uce ! con/itutional symptoms aris+ f septic processes & t !y reappe> on discont9u+ ! antiseptic treatm5t40 ,dak9 & ,dunham ,h&book ( ,antiseptics3 8,! ideal surgical antiseptic %\ld effect complete /]ilization )9 its sph]e ( action )\t caus+ any damage to animal cells4 ,at ! mom5t su* a sub/ance does n appe> likely to be f\nd1 b on ! o!r h& x is surpris+ to see h[ little damage may be done to animal tissues by "s active antiseptics4 ,an important me?od ( judg+ ( ! injuri\s action ( antiseptics is to inve/igate ! condition ( ! leucocytes 9 w\nds rec5tly treat$ ) ! sub/ance "u consid]ation4 ,9 g5]al x appe>s f exp]im5ts 9 vitro t1 ) ! /r5g? ( antiseptics commonly us$ 9 surg]y1 m]cury salts & hypo*lorites h relatively little effect on phagocytosis z comp>$ ) ph5ol 7,p>ry ,morgan74 ,x is a regul> ph5om5on to obs]ve activity ( ! leucocytes obta9$ f w\nds :i* h be5 rec5tly treat$ ) hypo*lorites4 ,+5i\s me?ods = det]m9+ ! influ5ce 9 vivo ( antiseptics on ! activities ( leucocytes h be5 work$ out by ,col4 ,c4 ,j4 ,bond4 8,9 addition to _! dis9fect+ action1 ! ,*lor9e antiseptics are /rong oxidiz+ ag5ts & deodorants & moreov] possess 9 high degree ! prop]ty ( decompos+ tox9s4 ,by ! regulat$ action ( hypo*lor\s acid1 ,dean has prep>$ a nontoxic dys5t]y vacc9e & x is a common obs]vation t ! free use ( hypo*lorites may r$uce ! con/itutional symptoms aris+ f septic processes & t !y reappe> on discont9u+ ! antiseptic treatm5t40 ,*lorax ,*lorax is said to be 8,a /able ,,*lor9e solution = int]nal use10 9 8,kidney ,conditions10 8,diabetes10 8,acute ,infections10 8,blood ,dicrasias10 8,li!mias & ,rheumatism10 & 8,n]v\s ,conditions40 ,x is claim$ to h ! same composition z t ( ,*loron ) ! addition ( #j4jaf p] c5t4 ( t9cture ( opium4 ,! ,a4 ,m4 ,a4 ,*emical ,laboratory report$ t ! free *lor9 9 ,*lorax 0 #j4ja gm4 p] hundr$ c4c4 & ! total am\nt ( active 78available07 *lor9 0 #j4be gm4 p] hundr$ c4c41 or #abe p] c5t4 ( ! am\nt claim$4 ,! laboratory notes t ?\gh ! *lor9 cont5t ( ,*loron & ,*lorax is claim$ to be ! same1 t ( ,*lorax actually is less4 ,?is is n surpris+ :5 ! pres5ce 9 ,*lorax ( r$uc+ sub/ances su* z alcohol is borne 9 m9d4 ,! laboratory concludes t ,*lorax is n ( reliable composition4 ,! foll[+ is typical ( ! 8case reports0 submitt$ to %[ ! value ( ,*lorax3 8,9 ,janu>y la/ ,i us$ ,*lorax on a case ( ,diabetes ,mellitus & ) excell5t results4 8,! pati5t _h be5 suff]+ = ab\t n9e ye>s & :5 fir/ br\ght to my c>e ,toxemia _h set 91 he 0 dr[sy1 irritable & unable to leave ! h\se4 ,i prescrib$ ,*lorax 9 teaspoonful doses f\r times a day & am pleas$ to say t 9 "o week he %[$ m>k$ improvem5t4 ,soon aft] he 0 able to leave ! h\se & att5d to 8 bus9ess & aft] two mon?s' treatm5t resum$ a normal diet & habits app>5tly )\t injuri\s effects4 8,i believe t 9 ?is case ,*lorax und\bt$ly prolong$ life40 ,no m5tion is made ( ! diet>y or o!r measures us$4 ,! wide v>iation 9 diabetes & its response to prop] diet is s well kn[n t ! noncommittal /atem5t conc]n+ ! b5eficial effects ( ,*lorax am\nts to no evid5ce at all 9 favor ( ! prep>ation4 ,! o!r 8case reports0 furni%$ by ! ,*lor9e ,products ,company1 ,inc41 :i* conc]n ! treatm5t ( ga/ric ulc]s1 acute alcoholic ga/ritis1 tonsillitis1 etc41 are equally unconv9c+4 ,9 fact1 no satisfactory evid5ce = ! cl9ical value ( ,*lorax has be5 pres5t$4 ,! foll[+ f ! adv]tis+ = ,*lorax is unw>rant$ & absurd3 8,m]cur\s *loride 7calomel7 is p]haps ! mo/ widely us$ int]nal antiseptic & alt]ative & has e/abli%$ itself 9 ! !rapy ( con/ipation1 *ol]a1 dys5t]y1 c>diac dropsy1 pleurisy1 malignant fev]1 mal>ia1 syphilis1 worms1 infecti\s diseases1 g\t & rheumatism2 li?ium *loride is p>ticul>ly efficaci\s 9 acute & *ronic p>5*ymat\s nephritis & 9 v>i\s li!mic conditions2 :ile ,opium has no rival z an anodyne & c be us$ to /abilize & cons]ve ! alkal9e res]ve ( ! body aga9/ ! acidos+ influ5ce ( infections40 ,fur!r1 on page #ad we f9d3 8,9 *ills & fev] mal>ia & o!r blood dicrasias1 ,,*lorax is indicat$ z an int]nal antiseptic & x ex]ts a b5eficial effect on ! c\rse ( ^! diseases40 ,! claims made = ,*lorax are exagg]at$ & mislead+4 ,numb] 8#c0 ,accord+ to ! label1 ,numb] 8#c0 is 8,a ,,/able ,,*lor9e rem$y = ! purification ( ! blood10 ) ! composition3 8,free ,*lor9e1 #j4ce p] c5t42 ,calcium ,*loride1 #j4cj p] c5t42 ,m]cur\s ,*loride1 #j4jc p] c5t42 ,li?ium ,*loride1 #j4jd p] c5t42 ,calcium ,hydrate1 #j4ja p] c5t42 ,opium1 #j4jb p] c5t42 ,e?yl ,alcohol1 #j4aj p] c5t42 wat] to #ajj p>ts40 ,x w be notic$ t ! composition claim$ = ,numb] 8#c0 is ess5tially simil> to t claim$ = ,*loron4 ,x diff]s f ,*loron 9 t ! am\nts ( "s ( ! con/itu5ts are some:at great]1 & 9 t1 l ,*lorax1 x conta9s "s t9cture ( opium4 ,! ,a4 ,m4 ,a4 ,*emical ,laboratory reports t ! free *lor9 9 a specim5 ( ,numb] 8#c0 0 #j4jbd gm4 9 #ajj c4c4 & ! total active 78available07 *lor9 #j4agc gm4 p] hundr$ c4c41 or ab\t #ej p] c5t4 ( ! claim$ am\nt4 ,! exam9ation indicates t ,numb] 8#c0 is ( unreliable composition4 ,! ,*lor9e ,products ,company1 ,inc41 submitt$ no cl9ical evid5ce = ,numb] 8#c0 to :i* x ref]s z 8our ,syphilis rem$y40 ,x /at$ t two physicians _h us$ ! prep>ation 8) good results10 & admitt$ t 8! company requires fur!r evid5ce be=e pu%+ x40 ,! ,c\ncil decl>$ 8,*loron10 8,*lorax0 & 8,numb] #8#c'0 9 conflict ) ! rules gov]n+ admission to ,new & ,non(ficial ,rem$ies4 ,all are ( unreliable composition 7conflict ) ,rule #a74 ,! !rapeutic claims made = ! prep>ations are n sub/antiat$ by acceptable evid5ce & are unw>rant$ & mislead+4 ,*loron is inf]ior z an antiseptic to ! well-kn[n surgical solution ( *lor9at$ soda on acc\nt ( its l[ *lor9 cont5t & uncontroll$ reaction4 ,!re is no w>rant = ! claim t ,*lorax is useful 9 ! treatm5t ( 8,kidney ,conditions10 8,diabetes10 8,acute ,infections10 8,blood ,dicrasias10 8,li!mias & ,rheumatism10 & 8,n]v\s ,conditions10 nor is !re w>rant = ! claim t 8,numb] #8#c'0 is a rem$y = ! purification ( ! blood or a 8,syphilis rem$y0 7conflict ) ,rule #f74 ,! names ( ^! ph>maceutical mixtures are n descriptive ( _! composition 7conflict ) ,rule #h74 ,all ?ree prep>ations are irrational4 ,no evid5ce has be5 furni%$ t ! li?ium salt is ( value 9 ! mixtures4 ,x is n rational to comb9e an active *lor9 prep>ation & a m]cury salt 9 "o mixture1 nor is !re evid5ce t ! addition ( opium to ! prep>ations propos$ = int]nal use is ( value or rational4 ,exp]im5tation ) ,numb] 8#c0 z a 8,syphilis rem$y0 is to be sev]ely condemn$ 9 t ^? on :om x is us$ w 9 ! meantime be depriv$ ( effici5t m$ication 7conflict ) ,rule #aj74--7;,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiai1 p4 #gj7 ,,el>son ,,omitt$ ,,f ,n4 ,n4 ,r4 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has au?oriz$ publication ( ! foll[+ report ann\nc+ ! omission ( ,el>son f ,new & ,non(ficial ,rem$ies4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,el>son1 n[ sold by ! ,w9?rop ,*emical ,company1 ,inc41 0 =m]ly sold 9 ! ,unit$ ,/ates by ! ,bay] ,co41 ,inc4 ,x 0 admitt$ to ,new & ,non(ficial ,rem$ies 9 #aiad4 ,! circul> issu$ by ! ,w9?rop ,*emical ,co4 conta9s sev]al /atem5ts m>k$ly at v>iance ) ! results ( an inve/igation made1 at ! reque/ ( ,fis*]1 by ,joa*imoglu 7,ar*4 f4 exp]4 ,pa?4 u4 ,ph>makol4 #gh3aiad74 ,! circul> /ates t ,el>son conta9s ab\t #ac p] c5t4 ars5ic4 ,joa*imoglu f\nd f #aj4h to #aa4a p] c5t4 to be pres5t4 ,! circul> /ates fur!r3 8,! fact t ,el>son repres5ts a lipoid-l *emical comb9ation ( ars5ic has an important be>+ ^u its absorption & utilization 9 ! sy/em 444 !re is good reason to believe t :5 ars5ic is adm9i/]$ 9 a /able1 lipoid-l comb9ation1 z 9 ,el>son1 x is m readily tak5 up by ! cells & m completely utiliz$ ?an :5 giv5 9 ! cu/om>y mann]40 8,z reg>ds ! behavior ( ,el>son 9 ! sy/em1 x has be5 %[n t its active con/itu5t1 *lor>s5o-beh5ol1 is almo/ completely absorb$ 9 ?is =m1 probably z a *lor-beh5olate ( sodium or potassium40 ,z a matt] ( fact1 ,joa*imoglu f\nd t v little ars5ic 0 absorb$ :5 ,el>son 0 giv5 to dogs & rabbits2 mo/ ( x 0 recov]$ f ! feces2 only traces 7 f\nd 9 ! liv] & kidneys & none 9 ! blood & bra94 ,! abs5ce f ! latt] organs %[s t ! lipoid solubility does n obta9 9 ! body4 ,x is claim$ 9 ! circul> t ,el>son has ! advantage ov] ,f[l]'s solution 89 t x is free f any irritat+ action ^u ! ga/ro-inte/9al tract02 x is /at$ t z _m z sixty tablets h be5 giv5 to dogs daily )\t any toxic effects4 ,joa*imoglu1 on ! o!r h&1 f\nd p[d]$ ,el>son to be v irritat+ to ! ga/ro-inte/9al tract2 also t ! dog c\ld n /& sixty tablets at all 7g> ni*t v]trag571 su* doses caus+ vomit+1 di>rhea & inte/9al hemorrhages2 on repeat$ adm9i/ration ! symptoms became progressively m sev]e4 ,joa*imoglu also f\nd t1 comp>$ on ! basis ( ars5ic cont5t1 ,el>son1 giv5 intrav5\sly1 is f t5 to twelve times z poison\s z ars5ic trioxid4 ,el>son is recomm5d$ = ! class ( cases 9 :i* ,f[l]'s solution is us$4 ,to sum up3 ,none ( ! special claims made = ,el>son--! ars5ic cont5t1 ready absorbability1 fre$om f irritat+ action on ! ga/ro-inte/9al tract & its alleg$ bett] adaptation = cont9u$ adm9i/ration--h be5 sub/antiat$2 on ! contr>y1 !y h be5 disprov$ z well z ! !ory ( its mode ( absorption propos$ by ,fis*] & ,klemp]]4 ,fur!rmore1 ,joa*imoglu f\nd t :5 x actually got into ! circulation 7intrav5\s injection7 9 ! =m 9 :i* ,fis*] & ,klemp]] suppos$ x to be absorb$1 x 0 f t5 to twelve times z toxic z ars5ic trioxid4 ,! ,c\ncil vot$ to omit ,el>son f ,new & ,non(ficial ,rem$ies because x is sold "u unprov$ & consequ5tly unw>rant$ claims & because x is an unsci5tific & relatively useless article4 ,el>son has n be5 %[n to h advantages ov] ,f[l]'s solution2 on ! contr>y1 9 "s respects at lea/1 x is inf]ior4--7,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiai1 p4 #ge47 ,,iodiphos ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,a report :i* appe>s bel[ 0 s5t ,*>les ,l4 ,heffn] = consid]ation4 ,no reply hav+ be5 receiv$1 ! ,c\ncil au?oriz$ its publication4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,iodiphos1 m>ket$ by ,*>les ,l4 ,heffn]1 ,brooklyn1 ,n4 ,y41 is decl>$ to conta9 f]ric citro-iod9e1 #f gra9s2 calcium glyc]ophosphate1 #h gra9s2 sodium glyc]ophosphate1 #h gra9s1 & hypophosphor\s acid1 #b m9ims 9 ea* fluid\nce1 & to pres5t 8! ,metallic & ,non-,metallic elem5ts3 ,iron1 ,iod9e1 ,phosphor\s1 ,calcium & ,sodium 7ea* 9 sep>ate ,basic comb9ation740 ,accord+ to ! label1 ,iodiphos is 8,,alt]ative1 ,,tonic1 ,,n]v9e & ,,anti-,,tub]cul>0 & is 8,= ,treatm5t ( ,,blood1 ,,n]ves & ,,pulmon>y ,,organs40 ,an adv]tis+ circul>#abi ass]ts t 8,iodiphos ex]ts its ,physiological action rapidly 9 h>d5+ ( ! ,art]ies1 ,high ,blood ,pressure1 ,anaemia1 ,gl&ul> ,swell+1 ,neura/h5ia1 ,hypo*ondria1 ,ph?isis1 ,bron*itis1 ,a/hma1 ,pneumonia & z an ,inte/9al ,antiseptic & ,appetiz]10 & decl>es x to be 8,indisp5sable z a ,tonic & ,re/orative40 #abi ,aft] publication ( ! =ego+ report _h be5 au?oriz$ by ! ,c\ncil1 a lett] 0 receiv$ f ,*>les ,l4 ,heffn]1 advis+ t ! di/ribution ( ! circul>s has be5 discont9u$4 ,9 ! adv]tis+ circul> x is av]r$ t 9 ! production ( ,iodiphos 8,*emi/ry ,aga9 ,aids ! ,mod]n ,physician40 ,iodiphos is ano!r in/ance :5 a decad5t polyph>macy proposes haphaz>d m$ication & s ob/ructs ! ef=ts ( mod]n m$ic9e to e/abli% ! use ( s+le drugs to meet def9ite indications4 ,iodiphos is inadmissible to ,new & ,non(ficial ,rem$ies because x is an irrational mixture ( drugs sold ) !rapeutic claims t are unw>rant$1 & "u a "n :i* is n descriptive ( its composition4--7,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiai1 p4 #ha47 ,,m]v5ol ,,& ,,arm]v5ol ,,n ,,admitt$ ,,to ,n4 ,n4 ,r4 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has au?oriz$ publication ( ! report :i* appe>s bel[ decl>+ ,m]v5ol & ,arm]v5ol1 m>ket$ by ! ,hille ,laboratories1 inadmissible to ,new & ,non(ficial ,rem$ies4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,m]v5ol is /at$ by ! proprietors--,! ,hille ,laboratories1 ,*icago--to be a hydrosol 7colloidal susp5sion7 ( ! sulphides ( m]cury & copp]1 conta9+ suffici5t sodium *loride to make x isotonic ) blood s]um1 & 8in]t proteid0 & 8c>bohydrate0 to /abilize ! colloidal susp5sion3 ea* cubic c5timet] is /at$ to conta9 #j4jje gm4 m]cury1 #j4jjaf gm4 copp]1 & #j4jjaf gm4 sulphur4 ,x is claim$ t ?is prep>ation is ( value 9 pneumonia1 influ5za1 & o!r conditions & diseases requir+ increas$ leukocytosis4 ,x is fur!r claim$ t ! prop]ties & !rapeutic effects ( ?is prep>ation are z foll[s3 8,practically non-irritant2 practically non-toxic2 l[] temp]ature1 (t5 crisis l2 l[] pulse1 ) bett] elim9ation2 greatly accel]at$ recov]y f ,influ5za2 few] ,pneumonia complications2 l[] mortality rate 9 ,influ5za & ,pneumonia2 rem>kable ,leucocyte /imulation40 ,adm9i/ration by m\? & by intramuscul> & intrav5\s injection are advocat$4 ,9 ! rec5t influ5za epidemic1 x is report$ t !rapeutic results ( "s value 7 obta9$ at ! ,great ,lakes ,tra9+ ,/ation & at ,=t ,%]idan4 ,! reports ( c]ta9 m$ical (fic]s indicate t ?is prep>ation seem$ to h "s effect on ! c\rse ( pneumonia & influ5za1 on ! temp]ature1 & on ! leukocyte c\nt4 ,b ^? conduct+ ! exp]im5ts /ate t x 0 8absolutely impossible0 to fulfil ideal conditions z to controls & o!r obs]vations at ! "t ! exp]im5ts 7 conduct$4 ,s f> z ! ,c\ncil kn[s1 no ef=t has be5 made to det]m9e ! pot5t con/itu5t1 or con/itu5ts1 ( ?is prep>ation2 :e!r ! m]cury1 ! copp]1 or ! prote9 9 ! mixture 0 responsible = ! claim$ b5efits is an op5 "q4 ,^! reports 7 giv5 c>eful consid]ation1 b x 0 decid$ n to accept ?is prep>ation because ( 7#a7 exagg]at$ !rapeutic claims1 conflict+ ) ,rule #f 7aside f ! report ( its use 9 influ5za & pneumonia at ! ,great ,lakes ,tra9+ ,/ation & ! ,po/ ,hospital at ,=t ,%]idan1 :i* reports are ( "w done & obs]vations made "u conditions :i* did n p]mit c>eful controls1 no evid5ce has be5 pres5t$ to ! ,c\ncil support+ ! !rapeutic claims7 & 7#b7 be+ an irrational mixture1 conflict+ ) ,rule #aj--;a mixture conta9+ colloidal m]cury1 copp] & sulphur ) prote9s & c>bohydrates 9 addition1 x is difficult to pr$ict ! *anges :i* occur 9 su* mixtures on /&+4 ,samples ( ,m]v5ol 7two #a-ounce bottles7 submitt$ by ! manufactur]1 ,june #e1 #aiai1 7 f\nd :5 op5$1 ,aug4 #ah1 #aiai1 to h und]gone decomposition4 ,a v disagreeable odor _h develop$1 ! liquid 0 turbid1 & a l>ge am\nt ( precipitate _h =m$4 ,arm]v5ol is /at$ by ! proprietors--,! ,hille ,laboratories1 ,*icago--to be a hydrosol 7colloidal susp5sion7 ( 8m]cury-copp]-sulph>s5ite0 conta9+ suffici5t sodium *lorid to make x isotonic ) blood s]um & 8in]t proteid0 & 8c>bohydrate0 to /abilize ! solution3 ea* cubic c5timet] is decl>$ to conta9 #j4jjbe gm4 ars5ic1 #j4jje gm4 m]cury1 #j4jjaf gm4 copp]1 & #j4jjcb gm4 sulphur4 ,! use ( ,arm]v5ol z advis$ by ! ,hille ,laboratories is ! same z t ( ,m]v5ol1 & 9 addition its use 9 syphilis is emphasiz$4 ,! criticisms ( ?is mixture are simil> 9 e respect to ^? direct$ aga9/ ,m]v5ol--! addition ( ars5ic introduces /ill ano!r factor ( unc]ta9ty4 ,aft] inve/igat+ ^! claims1 x 0 decid$ n to accept ?is prep>ation on ! gr\nd 7#a7 t ! !rapeutic claims are unprov$ & unw>rant$1 conflict+ ) ,rule #f1 & 7#b7 t ! mixture is an irrational "o1 conflict+ ) ,rule #aj4--7;,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiai1 p4 #hb47 ,,normal ,,ph5ol ,,s]um 7,,cano7 ,,& ,,me?yl-,,ph5ol ,,s]um 7,,cano7 ,,n ,,accept$ ,,= ,n4 ,n4 ,r4 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has adopt$ ! foll[+ /atem5t decl>+ ,normal ,ph5ol ,s]um 7,cano7 & ,me?yl-,ph5ol ,s]um 7,cano7 ineligible to ,new & ,non(ficial ,rem$ies4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,no /atem5t ( ! composition ( ^! prep>ations 0 submitt$ to ! ,c\ncil & none appe>s on ! labels ( ! trade packages4 ,h[ev]1 ! adv]tis+ circul> conta9s /atem5ts su* z3 8444 normal ph5ol s]um--ph5ol ) me?yl blue dissolv$ 9 anaphylactic s]um 4440 8444 a comb9ation ( human or horse s]um ) ,ph5ol & ,me?yl5e-blue1 !reby =m+ a new *emico-biologic product :i* he t]m$ ,me?yl-ph5ol ,s]um or1 *emically1 ,*loride ( ,ph5ol ,?ion9 ,tetrame?yl5e-,s]ic40 8,me?yl-ph5ol ,s]um is a *emico-biological product 9 :i* ,ph5ol is ! *ief factor4 ,ea* ampule ( #aj c4c4 conta9s ! !rapeutic equival5t ( #j4e gm4 7#g4e gra9s7 ( ,ph5ol40 ,f ! =ego+ x appe>s t bo? prep>ations conta9 ph5ol & me?yl?ion9e *loride 7me?yl5e blue7 & t ! second does n conta9 me?yl ph5ol 7cresol7 z ! "n w\ld indicate4 ,no def9ite evid5ce = ! value ( ^! prep>ations is br\ght =w>d & ev5 ! manufactur] is con/ra9$ to caution1 8,we assume no responsibility = ! !rapeutic action ( ! s]um44440 ,on ! o!r h& !re are a great _m /atem5ts 9 ! pap]s ( ,cano & 8 colleagues to :i* exception mu/ be tak54 ,( ^!1 f among _m simil>1 ! foll[+ /atem5ts are to be cit$ & comm5t$ on3 8,accept+ t ! gonorrheal infection gives sy/emic toxemia f absorption ( ! tox9s 4440 ,x is ! g5]al op9ion t 9 ! majority ( in/ances !re is no sy/emic toxemia4 8,! te*nique ( intrapro/atic injection1 :ile less simple ?an t ( ! intrav5\s1 is by no means s difficult or complicat$ z to place x exclusively 9 ! category ( ! urologi/40 ,?is obvi\sly is an attempt to enc\rage ! g5]al use ( ^! prep>ations & to m9imize ! necessity = c>eful /udy & special skill 9 _! employm5t4 ,x is mo/ unwise = "o to attempt intrapro/atic injections unless he is specially tra9$ 9 ! te*nique ( ?is proc$ure4 8,?is injection to be p]=m$ aft] ! #e? or #f? intrav5\s injection ( ,me?yl-ph5ol ,s]um44440 ,intrav5\s injections h a place 9 sane !rapy only :5 ! m$icam5t to be s adm9i/]$ is ( kn[n composition & :5 evid5ce is available :i* gives assurance t def9ite results %all foll[ its use4 ,9 ! abs5ce ( ^! conditions x is manife/ly unwise & ev5 unexcusable to employ any m$icam5t 9 ?is mann]1 & its repeat$ use is repreh5sible4 8,intrav5\s injection ( ,me?yl-ph5ol ,s]um alt]nat+ ) intrav5\s injections ( m]cury %\ld be giv5 e #dh h\rs until infection is "u control40 ,?is quotation fur!r emphasizes t ! treatm5t1 z advis$1 c>ries ) x a c]ta9 elem5t ( dang]4 8,me?yl5e blue prev5ts ! ph5ol f ex]t+ its usual action ^u ! r$ blood corpuscles1 & ensures rapid elim9ation ?r\gh heal?y kidneys4 ,x pres]ves ! antiseptic p[] ( ! ph5ol & prev5ts ! ph5ol f int]f]+ ) ! *emico-biological function ( ! :ite & r$ blood cells4 ,! s]um compon5t favors *emotaxis1 x /r5g!ns bodily def5se1 x prev5ts anaphylaxis ev5 9 debilitat$ pati5ts1 & x replaces ! resi/ance :i* has be5 impair$ by ! dem&s t h already be5 made ^u x40 ,no evid5ce is submitt$ to sub/antiate ^! claims4 ,x seems /range t ph5ol %\ld lose its p[] & t ?is %\ld be re/or$ by ! me?yl5e blue4 8,x has a refractory *emico-biological action1 & ex]cises no vici\s effect on ! r$ blood corpuscles 9 ! circulation1 b1 on ! contr>y1 by its in(f5sive pres5ce1 x :olly pres]ves all ( ! physiological prop]ties ( ! blood40 ,:at 8a refractory *emico-biologic action0 is1 is n cle>1 b !re is no evid5ce t ?is prep>ation has any action :i* might be def9$ z 8refractory *emico-biological10 t its pres5ce is in(f5sive or t x :olly pres]ves all ! physiologic prop]ties ( ! blood4 8,! treatm5t ( gonorrhea by ,cano's !ory 444 is firmly bas$ ^u *emico-biological facts & accept$ au?oritative !ories & be>s ! same relation to gonorrhea t intrav5\s injections ( ars5icals be> to syphilis40 ,q an exagg]at$ & unw>rant$ /atem5t4 ,9 ! same way1 objection is tak5 to ! foll[+ quotations3 8,ph5ol adm9i/]$ intrav5\sly 9 comb9ation ) me?yl5e blue1 to protect ! r$-blood globule1 und]goes no *ange1 & pres]ves all ( its actual antiseptic effect on ! gonococcus & its tox9s z ?\gh employ$ 9 ! te/ tube40 8,:5 ?us introduc$ into ! human body its elim9ation is unique1 effective1 antiseptic1 g]micidal1 be+ completely & exclusively ?r[n (f ?r\gh ! kidneys 9 a p]iod v>y+ f "o-half to twelve h\rs )\t local injury or di/urbance to ! g5]al economy40 8,comb9ations ( ph5ol are un/able1 b !y d h ! advantage ( mitigat+ direct action on ! cells & globules4 ,x is also kn[n t ord9>y ph5ol has a coagulant action on ! album9s & an oxidiz+ p[] on ! tissues1 :i* p[]1 if p]man5t1 produces gangr5e4 ,by virtue ( ?is dual action x !re=e acts z a modifi]2 by its oxidiz+ p[] on ! g]m x is g]micidal1 & prev5ts ! gr[? ( ! gonococcus2 & by its coagulant p[] on ! tox9s x relieves p>agonococcal lesions 7mono- & poly-ar?ritides7 & affections ( ! s]\s organs 7endo- & p]ic>ditis1 m5+itis71 & "s def9ite sy/emic di/urbances1 ! pa?ology ( :i* is (t5 confus$ ) t ( o!r infections40 8,lymphocytosis is (t5 p]si/5t 9 "s individuals 9 :om ! int]nal secretions & ! processes ( assimilation & disassimilation are defici5t2 & because ( ! lack ( ^! ! organic physiological f]m5ts are insuffici5t = ! me*anism ( nutrition & ! ph5om5a ( hematopoiesis40 ,until pro( is available %[+ t ph5ol1 adm9i/]$ intrav5\sly 9 ! quantities employ$ 9 ,cano's ,normal ,ph5ol ,s]um & ,cano's ,me?yl-,ph5ol ,s]um1 acts z a g]micide & me?yl?ion9e *loride 78me?yl5e blue07 prev5ts ! delet]i\s effects ( ph5ol on ! r$ blood corpuscles2 t repeat$ intrav5\s injections ( ph5ol & m]cury are )\t dang]2 t !re is no dang] ( anaphylaxis2 t ! physiologic prop]ties ( ! blood are pres]v$ by ^! m$icam5ts2 &1 f9ally1 t ^! prep>ations h an effect on gonorrhea & its complications1 ^! sub/ances ,normal ,ph5ol ,s]um 7,cano7 & ,me?yl-,ph5ol 7,cano71 are inadmissible to ,new & ,non(ficial ,rem$ies4 ,! foll[+ quotations tak5 f ! circul> are admissions t ^! prep>ations are n innocu\s3 8,t ! economy w tol]ate to a surpris+ degree sub/ances directly introduc$ ?r\gh ! blood /ream is n[ well kn[n4 ,by ! intrav5\s injection ( #aj c4c4 ( me?yl-ph5ol s]um we ?r[ into ! human body a massive dose ( an ali5 sub/ance4 ,! imm$iate effect ( ?is injection is ^u ! c5tral n]v\s sy/em4 ,! recipi5t usually becomes ei!r pale or suffus$1 he has a r++ 9 8 e>s1 has a s5sation ( great altitude1 & occasionally has a dryness ( ! fauces & a metallic or a g>lic ta/e40 8,9 "s pati5ts second>y reactions occur 9 f "o to f\r h\rs aft] injection4 ,! ph5om5a we h obs]v$ 9 ^! second>y reactions are pron\nc$ *ill & rigor 4440 ,!re is no d\bt t consid]able h>m may be done by ! intrav5\s & by ! intrapro/atic adm9i/ration ( ^! prep>ations & until !re is good evid5ce %[+ ! !rapeutic value ( ! treatm5t1 ! r\t9e use ( ^! prep>ations1 except p]haps at hospitals 9 select$ & well controll$ & c>efully gu>d$ cases1 is to be /rongly disc\rag$4 ,:5 ! =ego+ /atem5t 0 s5t to ! ,mul=d ,company = comm5t1 ! firm submitt$ a lett] f ,dr4 ,p]ry ,t[ns5d to ! ,mul=d ,company 9 :i* he decl>$ t ! results obta9$ ) ! ,cano prep>ations _h be5 satisfactory & )\t unt[>d results4 ,9 ?is lett]1 ,dr4 ,t[ns5d propos$ t a s]ies ( injections ) ^! prep>ations be c>ri$ out "u ! obs]vation ( memb]s ( ! ,c\ncil & ! sup]vision ( ,dr4 ,cano or himself4 ,! report ( ! ,c\ncil1 ! lett] f ! ,mul=d ,company & t ( ,dr4 ,t[ns5d 7 s5t to a numb] ( urologi/s = _! op9ion conc]n+ ?is :ole matt]4 ,x 0 expla9$ t ! ref]ee held t no reason _h be5 pres5t$ :i* w\ld w>rant ! ,c\ncil to dep>t f its cu/om>y proc$ure1 namely1 to require t cl9ical evid5ce be submitt$ 9 ! =m ( publi%$ reports :i* p]mit inve/igation & v]ification by indep5d5t obs]v]s b t1 be=e mak+ fur!r recomm5dation to ! ,c\ncil1 he desir$ ! op9ion ( urologi/s ( recogniz$ /&+ conc]n+ ! report submitt$ to ! ,mul=d ,company4 ,all replies receiv$ approv$ ! ,c\ncil's position4 ,! foll[+ is "o ( ! replies receiv$3 ,y\r lett] 9 reg>d to ,normal ,ph5ol ,s]um 7,cano7 & ,me?yl-,ph5ol ,s]um 7,cano7 receiv$4 ,i wi% to /ate t ,i h read ! correspond5ce betwe5 ! ,c\ncil & ,h4 ,k4 ,mul=d ,co4 & 9 my op9ion ! ref]ee & ! ,c\ncil are q correct 9 _! attitude 9 ! matt]4 ,9 my op9ion ,i w\ld emphasize ! foll[+3 7#a7 ,!re is absolutely no?+ ab\t ! rem$ies direct$ specifically aga9/ ! gonococcus & no evid5ce to %[ t any action aga9/ !m is obta9$4 ,z we "k !re are c]ta9 /ates ( normal s]um :i* are highly toxic & any normal s]um f ano!r animal w produce di/urbances 9 man :5 inject$ intrav5\sly--p>ticul>ly if repeat$4 ,! addition ( sub/ances to s]um normal or o!rwise is apt to & frequ5tly does r5d] t s]um highly toxic6 ,! sub/ances add$ 9 ! in/ances ref]r$ to--ph5ol & me?yl5e blue are n 9 any way calculat$ to less5 ! toxicity ( s]um4 ,! elem5t ( dang] exi/+ 9 ! indiscrim9ate use ( s]ums intrav5\sly is1 9 my op9ion1 increas$ by ! addition ( ! sub/ances m5tion$1 & x w\ld be unwise to enc\rage ! g5]al use ( any su* rem$ies4 ,fur!rmore ! products are condemn$ by ! v evid5ce ( ! orig9ators & _! admissions are q suffici5t to det] anyone f us+ ! products z !y sugge/4 ,z to ! intrapro/atic injections ) ! s]ums x does n at all meet my views2 al?\gh ! introduction ( s]ums by ?is r\te h be5 frequ5tly advocat$ & ,i h p]sonally c>ri$ ?is mode out ,i _c all[ ! impression to g out t x c\ld be done 9 a r\t9e mann]--nor t no ill results c\ld foll[--= ,i h se5 o!rwise4 ,fur!rmore f !oretical /&po9t s]ums ne$ n be giv5 9 ?is way4 ,9 consid]ation ( ! op9ion express$ by ! ,c\ncil's consultants ! ref]ee recomm5d$ t ,normal ,ph5ol ,s]um 7,cano7 & ,me?yl-,ph5ol ,s]um 7,cano7 be decl>$ ineligible = ,new & ,non(ficial ,rem$ies because ( conflict ) ,rule #f 7unw>rant$ !rapeutic claims7 )\t consid]+ possible conflicts ) o!r rules1 & t publication ( ! report be au?oriz$4--7,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiai1 p4 #he47 ,,soam9 ,,omitt$ ,,f ,n4 ,n4 ,r4 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,soam9 is ! "n "u :i* ! firm ( ,burr\ghs ,wellcome & ,company sells its br& ( sodium arsanilate4 ,! ,c\ncil direct$ ! omission ( ,soam9 f ,new & ,non(ficial ,rem$ies & au?oriz$ publication ( ! report :i* appe>s bel[ aft] ! proprietors ( ! product _h decl9$ to )draw or suitably revise ! unw>rant$ !rapeutic claims :i* x made4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,! propriet>y br& 8,soam90 ( sodium arsanilate 0 admitt$ to ,new & ,non(ficial ,rem$ies sev]al ye>s ago at a "t :5 ! !rapeutic value ( arsanilic acid _h n be5 def9itely det]m9$4 ,exp]i5ce ) ?is drug has %[n t x is f> m dang]\s & also has a m limit$ field ( usefulness ?an 0 at fir/ recogniz$4 ,! proprietors ( ! ,soam9 br& h cont9u$ to include 9 ! li/ ( conditions 9 :i* x 8w\ld seem0 to be a 8v effective ag5t0 c]ebrosp9al m5+itis & pellagra2 9 fact1 m5+itis is ! fir/ 9 ! li/ ( conditions m5tion$1 syphilis ! second & pellagra ?ird4 ,9 support ( _! belief 9 ! efficacy ( ! rem$y 9 m5+itis1 ?ree reports1 publi%$ f six to n9e ye>s ago1 are quot$4 ,9 "o ( ^! x is /at$ t two pati5ts 87 cur$02 9 ano!r report1 sev5 ( eight pati5ts 9 :om ! cl9ical1 b n ! microscopic1 diagnosis ( m5+itis _h be5 made 7 report$ z hav+ recov]$2 9 ! ?ird report1 fifty-six ( n9ety cases 7 report$ cur$2 9 ?is l>g] s]ies ( cases ! au?or neglects to /ate ! me?od ( adm9i/ration4 ,! firm quotes b "o pap] 7:i* is a v uncritical report7 9 reg>d to pellagra4 ,x seems to ! ,c\ncil t ! evid5ce ( value ( sodium arsanilate 9 ^! conditions 7:i* are n[ treat$ by m rational me?ods7 is too slight to ju/ify ! emphasis laid on x by ! firm1 especially z sodium arsanilate is admitt$ly a dang]\s ag5t1 sev]al cases ( bl9dness hav+ be5 report$ f its use4 ,= ^! reasons x 0 vot$ to omit ,soam9 f ,new & ,non(ficial ,rem$ies4--7,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiai1 p4 #hi47 ,,"s ,,mix$ ,,vacc9es ,,n ,,admitt$ ,,to ,n4 ,n4 ,r4 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has au?oriz$ publication ( ! foll[+ report4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,! consid]ation ( ! foll[+ 8mix$0 vacc9es 0 reque/$ by ,f4 ,i4 ,lack5ba*1 ,san ,francisco3 ,special ,bact]ial ,vacc9e ,no4 #b 7,/aph-,/rep4 ,bact]97 conta9+ kill$ ,/aphylococcus albus1 ,/aphylococcus aureus & /reptococcus4 ,special ,bact]ial ,vacc9e ,no4 #c 7,pneumo-,/aph-,/rep4 ,bact]97 conta9+ kill$ ,/aphylococcus albus1 ,/aphylococcus aureus1 /reptococcus & pneumococcus4 ,special ,bact]ial ,vacc9e ,no4 #d 7,pneumo-,/aph-,/rep-,coli ,bact]97 conta9+ kill$ ,/aphylococcus albus1 ,/aphylococcus aureus1 ,/aphylococcus citreus1 ,bacillus coli1 /reptococcus & pneumococcus4 ,special ,bact]ial ,vacc9e ,no4 #e 7,influ5za ,comb9$ ,bact]97 conta9+ kill$ ,/aphylococcus albus1 ,/aphylococcus aureus1 ,bacillus ,fri$lnd]1 ,bacillus influ5zae1 ,micrococcus cat>rhalis1 /reptococcus & pneumococcus4 ,special ,bact]ial ,vacc9e ,no4 #aa 7,pneumo-,/rep4 ,bact]97 conta9+ kill$ /reptococcus & pneumococcus4 ,special ,bact]ial ,vacc9e ,no4 #ae 7,comb9$ ,:oop+ ,c\gh ,bact]97 conta9+ kill$ ,bacillus p]tussis1 ,/aphylococcus albus1 ,/aphylococcus aureus1 ,micrococcus cat>rhalis1 ,bacillus influ5zae1 /reptococcus & pneumococcus4 ,special ,bact]ial ,vacc9e ,no4 #af 7,mix$ ,gonococcus ,bact]97 conta9+ kill$ gonococcus1 ,/aphylococcus albus1 ,/aphylococcus aureus1 ,bacillus coli1 diph!roid bacillus1 /reptococcus & pneumococcus4 ,mr4 ,lack5ba* /ates t ^! bact]ial mixtures 7 prep>$ = him by ,e4 ,r4 ,squibb ,sons4 ,_! sale 9 int]/ate comm]ce is p]mitt$ "u ! lic5se grant$ to ! latt] firm by ! ,u4 ,s4 ,treasury ,dep>tm5t4 ,h[ev]1 no evid5ce ( any k9d 0 pres5t$ to ! ,c\ncil prov+ ! !rapeutic efficacy ( ! sev]al mix$ vacc9es4 ,z a mixture ( two or m k9ds ( organisms is accept$ = ,new & ,non(ficial ,rem$ies only if !re is satisfactory evid5ce t its !rapeutic use is rational1 ! ,c\ncil decl>$ ! sev]al vacc9e mixtures ineligible = ,new & ,non(ficial ,rem$ies 7,rule #aj74--7;,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiai1 p4 #ij47 ,,somn(orm ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil exam9$ ! available evid5ce = ,somn(orm1 sold by ,/rat=d-,cookson ,company1 successors to ,e4 de ,trey & ,sons1 & f\nd ! prep>ation inadmissible to ,new & ,non(ficial ,rem$ies4 ,! ,c\ncil au?oriz$ publication ( ! report :i* appe>s bel[4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,somn(orm is sold 9 ! ,unit$ ,/ates by ,/rat=d-,cookson ,company1 successors to ,e4 de ,trey & ,sons4 ,accord+ to ! label on a package ( ,somn(orm s5t ! ,c\ncil4 8,?is mixture conta9s ,*loride ( ,e?yl1 #hc p] c5t42 ,*loride ( ,me?yl1 #af p] c5t42 ,bromide ( ,e?yl1 #a p] c5t40 ,al?\gh ,somn(orm has be5 on ! m>ket = a long "t1 ! publi%$ reports pres5t no pro( t x is sup]ior to e?yl *lorid us$ alone4 ,moreov]1 ! publi%$ reports & /ati/ics d n necess>ily apply to ! ,somn(orm n[ sold = ! reason t mixtures ( v>y+ composition h be5 sold z ,somn(orm 9 ! pa/4 ,?us1 :5 ,somn(orm 0 consid]$ by ! ,c\ncil 9 #aiji1 x 0 claim$ to be compos$ ( *loride ( e?yl1 #fj p] c5t42 *loride ( me?yl1 #ce p] c5t41 & bromide ( e?yl1 #e p] c5t4 ,f$]al *emi/s f\nd1 h[ev]1 t x conta9$ no bromide ( e?yl 7,notice ( ,judgm5t ,no4 #ega74 ,x is a "q1 !re=e1 :e!r a giv5 report applies to a mixture conta9+ #e p] c5t4 bromide ( e?yl1 #a p] c5t4 ( ?is sub/ance1 or none at all4 ,! pres5t adv]tis+ booklet = ,somn(orm does n pres5t acceptable evid5ce ( ! !rapeutic value ( ! prep>ation4 ,an ignorance conc]n+ ! elem5t>y facts ( physiology & ph>macology is evid5t 9 ! second s5t5ce3 :5 hav+ /at$ t 8,somn(orm is ! result ( sev]al ye>s ( /udy & inve/igation by ,dr4 ,george ,roll&1 ,dean ( ! ,bordeau ,d5tal ,s*ool10 ! pamphlet cont9ues3 8,he s\ght an ane/hetic :i* w\ld ent]1 dwell 91 & leave ! body 9 ! same mann] t oxyg5 does44440 ,! claim z to ! value ( ! #a p] c5t4 ( e?yl bromide 9 ! mixture is highly improbable2 c]ta9ly no evid5ce 9 support ( ! claim$ value ( ?is con/itu5t is available to ! ref]ee4 ,no evid5ce is submitt$ :i* proves ! claim ( sup]iority ( ,somn(orm ov] simil> prep>ations1 ass]t$ 9 ! foll[+3 8,! peculi> mann] 9 :i* ! elem5ts are comb9$ is :at makes ,somn(orm at once s effici5t & s safe40 ,! ,c\ncil decl>$ ,somn(orm inadmissible to ,new & ,non(ficial ,rem$ies because1 9 ! abs5ce ( acceptable evid5ce %[+ its exceptional safety & value1 ! claims are unw>rant$ 7,rule #f71 & because ! "n ( ! mixture is n descriptive ( its composition 7,rule #h74--7;,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiai1 p4 #ij47 ,,tablets ,,=mo?alates ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has au?oriz$ publication ( ! foll[+ report :i* decl>es ,tablets ,=mo?alates 7,tailby-,nason ,company1 ,bo/on1 ,mass47 ineligible = ,new & ,non(ficial ,rem$ies4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,tablets ,=mo?alates are sold by ,tailby-,nason ,company1 ,bo/on1 ,mass4 ,on ! label a =mula is giv53 8,con/itu5ts3 ,acetanilid #b gr42 ph5olph?ale9 #a_/b gr4 ,9 a balanc$ comb9ation ) ,hexam5e a "n sometimes appli$ to hexame?yl5am9 & ,oil ( ,c9namon4 ,indications3 ,influ5za1 ,colds1 ,grippe1 ,heada*e1 ,neuralgia1 ,rheumatism40 ,! same =mula is giv5 9 adv]tisem5ts & 9 ?is adv]tisem5t x is claim$ t !y are 8,= ,influ5za & ,grip0 & if 8giv5 9 ! acute /age may av]t a s]i\s attack0 7,bo/on ,m4 ,s4 ,j41 ,oct4 #c1 #aiah74 ,! dose is giv5 z "o to two tablets at #f p4 m4 & repeat at b$times4 ,! ,a4 ,m4 ,a4 ,*emical ,laboratory report$ t ! tablets weigh an av]age ( #j4dhhb ,gm41 or #g-a_/b gra9s2 t !y h ! odor & ta/e ( c9namon2 & t !y conta9 hexame?yl5am91 are neutral & !re=e give up no =maldehyde 9 ! pres5ce ( wat] alone4 ,! ,laboratory fur!r report$ t !y conta9 ph5olph?ale9 & acetanilid4 ,^! tablets 7 direct$ to be tak5 int]nally & !re=e _! effect 0 n int5d$ to be local4 ,! am\nt ( hexame?yl5am9 0 n det]m9$1 b 9 any case c\ld n exce$ #e gra9s p] tablet4 ,x is evid5t t #d gra9s ( acetanilid & #aj gra9s ( hexame?yl5am9 & #a gra9 ( ph5olph?ale9 79 two tablets7 8if giv5 9 ! acute /age0 ( influ5za w\ld n 8av]t a s]i\s attack10 z claim$ 9 ! adv]tisem5ts4 ,! ,c\ncil decl>$ ,tablets ,=mo?alates inadmissible to ,new & ,non(ficial ,rem$ies4--7,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiai1 p4 #ib47 ,,triple ,,ars5ates ,,) ,,nucle9 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has decl>$ ,triple ,ars5ates ) ,nucle9 ,no4 #a & ,triple ,ars5ates ) ,nucle9 ,no4 #b1 tablets m>ket$ by ! ,abbott ,laboratories1 inadmissible to ,new & ,non(ficial ,rem$ies because unw>rant$ !rapeutic claims 7,rule #f7 are made = !m & because !y pres5t an illogical comb9ation ( drugs 7,rule #aj74 ,! publication ( ! foll[+ report has be5 au?oriz$ by ! ,c\ncil4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,! foll[+ claims are made = ,triple ,ars5ates ) ,nucle93 8,puts #8pep' & /r5g? back into t pati5t recov]+ f ,spani% ,influ5za1 pneumonia1 typhoid1 or surgical op]ation4 ,an extremely p[]ful recon/ructive tonic4 ,try x = t #8run d[n' feel+40 ,triple ,ars5ates ) ,nucle9 is said to conta9 8,/ry*n9 ,ars5ate gr4 #a_/abh1 ,qu99 ,ars5ate gr4 #a_/fd1 ,iron ,ars5ate gr4 #a_/fd1 ,nucle9 ,solution m9s4 #d40 ,a second prep>ation1 ( d\ble /r5g?--,triple ,ars5ates ) ,nucle9 ,no4 #b--;is also adv]tis$4 ,! ,c\ncil vot$ n to accept ^! prep>ations = ,new & ,non(ficial ,rem$ies on ! foll[+ gr\nds3 ,! quantities ( qu991 iron & nucle9 9 ! doses repres5t$ 9 ^! mixtures are negligible2 ?us1 "o tablet ( ,triple ,ars5ates ) ,nucle9 conta9+ #a_/fd gra9 ( qu99 ars5ate conta9s only ab\t #a_/ij gra9 ( anhydr\s qu992 ! tablet conta9+ #a_/fd gra9 ( iron ars5ate conta9s #a_/baj gra9 ( iron2 #d m9ims ( ! nucle9 solution 7assum+ x to be ! 8,nucle9 ,solution-,abbott07 w\ld conta9 b #b_/e ( a gra9 ( nucle9--a sub/ance :i* ev5 9 l>ge doses is ( que/ionable !rapeutic value4 ,! am\nts ( iron & nucle9 conta9$ 9 doses ( ?is prep>ation are insignificant 9 comp>ison ) ! am\nts pres5t 9 ord9>y foods4 ,! only sub/ances pres5t 9 ev5 small !rapeutic doses are /ry*n9 & ars5ic4 ,! effects ( ars5ic & /ry*n9 are v diff]5t & !re are comp>atively few conditions 9 :i* !y %\ld be prescrib$ at ! same "t4 ,h5ce a prep>ation conta9+ ^! two 9 fix$ proportions is illogical4--7,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiai1 p4 #ib47 8,,anti-,,pneumococcic ,,oil0 ,,& ,,! ,,use ,,( ,,camphor ,,9 ,,pneumonia ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has adopt$ & au?oriz$ publication ( ! report :i* appe>s bel[4 ,?is report decl>es 8,anti-,pneumococcic ,oil0 7a solution ( camphor 9 oil sold by ,eim] & ,am5d1 ,new ,york7 ineligible = ,new & ,non(ficial ,rem$ies because 7#a7 ! recomm5dations = its use 9 pneumonia are n w>rant$ by ! evid5ce1 7#b7 ! "n is n descriptive ( its composition b is !rapeutically sugge/ive1 & 7#c7 ! sale ( a solution ( camphor 9 oil "u a "n nondescriptive ( its composition is unsci5tific & a h9drance to !rapeutic progress4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,! ,c\ncil hav+ decid$ to consid] ,anti-,pneumococcic ,oil 7,eim] & ,am5d1 ,new ,york71 ! prep>ation 0 assign$ to ! ,committee on ,!rapeutics = report4 ,! report t foll[s 0 made by a memb] ( ?is committee3 ,accord+ to ! adv]tis+1 ,anti-,pneumococcic ,oil is a 8tw5ty-five p] c5t4 solution ( camphor 9 a ?9 oil0 :i* 0 8orig9at$0 by ,augu/ ,seib]t1 ,m4,d4 ,! foll[+ directions are giv5 = its use3 8#aj c4c4 7#aej m9ims7 to e #ajj p\nds ( body weight1 to be inject$ hypod]mically e eight to twelve h\rs 9 pneumococcic pneumonia1 z soon aft] ! initial *ill z possible40 ,x is claim$ t ! prescrib$ dose "o h\r be=e g5]al ane/hesia beg9s1 8safegu>ds aga9/ po/op]ative pneumonia10 &1 t 8animals c s be immuniz$ aga9/ lat] & o!rwise fatal intrav5\s pneumococcic infection 7,boehnke1 ,in/itute = ,exp]im5tal ,!rapy1 ,frank=t740 ,! advice is giv53 8,9 pneumococcic m5+itis1 endoc>ditis & pleuritis1 #c ( salicylic acid %\ld be add$ to ?is oil40 ,9 an article by ,seib]t1 8,camphor & ,pneumococci0 7,m$ical ,record1 ,april #bj1 #aiab71 a repr9t ( :i* is us$ to adv]tise ,anti-,pneumococcic ,oil1 previ\s "w 7,mn*51 m$4 ,w*ns*r41 ,no4 #cf1 #aiji7 is m5tion$ z ! />t+ po9t = ! use ( camphor 9 pneumonia4 ,9 ?is article1 ! au?or reports 8 fir/ case1 t ( a "y woman :o ent]$ ,/4 ,francis' ,hospital on ! ?ird day aft] ! initial *ill 8) ! symptoms ( sev]e toxemia 7unconsci\s1 temp]ature #aje4e ,f41 pulse #acj1 & respiration #dj7 & involvem5t ( bo? l[] lobes40 8,l>ge doses ( camphor10 #ab c4c4 ( a #bj p] c5t4 solution1 7 inject$ hypod]mically 8e twelve h\rs1 result+ 9 gradual improvem5t & recov]y by ! f\r? day1 )\t a crisis40 ,seib]t reports success 9 its use 9 tw5ty-"o cases1 b gives no case hi/ories or protocols4 ,he admits1 h[ev]1 t 9 f\r out ( sixte5 cases1 foll[+ ! fir/ tw5ty-"o s report$ c]ta9 8limitations ( ?is treatm5t 7 obs]v$10 & a 8sudd5 rise ( temp]ature 9 two pati5ts on ! second & ?ird days ( treatm5t1 respectively1 prov$ to be due to pneumococcic nephritis1 promptly subdu$ by appropriate doses ( urotrop91 :ile ! camphor injections 7 cont9u$ & result+ 9 spe$y recov]y40 ,he fur!r admits t empyema occurs1 & /ates3 8,?is proves t ! camphor br\ght into ! blood _c prev5t ! z yet liv+ organisms1 con/antly ent]+ ! blood curr5t f ! affect$ alveoli1 f coloniz+ 9 ! r5al & pleural tissue40 ,he reports1 among ?irty-sev5 pati5ts treat$ 9 ?is mann]1 "o dea?1 t ( a man #fh ye>s old1 weigh+ #bjj p\nds1 ) a fatty he>t4 ,he>t failure 0 ! real cause ( dea?4 ,seib]t also reports "s v incomplete exp]im5tal "w2 ,dr4 ,h5sel1 assi/ant & pa?ologi/ ( ! ,g]man ,hospital1 f\nd t 8#a_/aj1jjj "p ( camphor add$ to ! usual culture m$ia inhibit$ ! gr[? ( pneumococci1 :ile ! controls all ?riv$02 ,dr4 ,j4 ,c4 ,wel*1 pa?ologi/ ( ! ,ly+-9 ,hospital1 f\nd t rabbits infect$ ) le?al doses ( pneumococcus cultures intrav5\sly 7 sav$ by l>ge doses ( camphorat$ oil2 fragm5t>y protocols are giv54 ,! assi/ant pa?ologi/ ( ,/4 ,francis' ,hospital c>ri$ on ! exp]im5tal "w1 add+ salicylic acid to ! camphor4 ,no blood cultures are report$4 ,! conclusion rea*$ by ,dr4 ,seib]t is t salicylic acid up to #c p] c5t41 add$ to ! camphorat$ oil1 is effective 9 prev5t+ pleural infection4 ,9 ! article by ,dr4 ,seib]t1 !re appe> mo/ sket*y reports ( cases1 recov]y be+ report$ )\t crisis 9 f ?ree to n9e days4 ,! ref]ee has made a c>eful se>* ( ! lit]ature1 ) ! foll[+ results3 ,boehnke 7,b]l4 kl94 ,w*ns*r4 #ej3hah1 #aiac71 us+ :ite mice1 fail$ to confirm ! exp]im5ts report$ 9 ,seib]t's pap]1 unless camphorat$ oil 7 giv5 be=e ! pneumococci1 & ev5 !n1 he felt t ! results 7 too irregul> to be ( great significance4 ,:5 giv5 ) anti-pneumococcic s]um1 h[ev]1 he felt t !re 0 "s b5efit to be se5 by ! adm9i/ration ( camphor2 8 protocols1 h[ev]1 are n detail$4 ,!re is no report ( blood cultures1 etc4 ,ano!r work]1 ,h4 ,leo 7,deuts*4 m$4 ,w*ns*r4 #ci3fij1 #aiac71 report$ t camphor wat] giv5 intrav5\sly prolong$ ! lives ( ?irty-eight rabbits inoculat$ ) pneumococci4 ,"h aga9 !re 7 no adequate protocols & v little evid5ce ( c>eful exp]im5tal "w appe>s4 ,9 ! lit]ature ( ! pa/ t5 ye>s1 !re appe> sket*y cl9ical articles on ! value ( huge doses ( camphor 9 pneumonia4 ,m>kevit* 7,russk4 ,vra*1 ,june #bg1 #aiad2 ab/r41 ,! ,j\rnal1 ,dec4 #e1 #aiad1 p4 #bjha7 treat$ #bbf cases ( pneumonia ) #e c4c4 ( camphorat$ oil hypod]mically f\r times daily1 at ! same "t giv+ digitalis 7am\nt n /at$71 ) a mortality ( #f4f p] c5t41 :]eas1 9 #cbb cases untreat$1 !re 0 a mortality ( #ac4c p] c5t4 ,he reports #acc grave cases2 sixty-six receiv$ no camphor2 #dh p] c5t4 di$4 ,( sixty-sev5 treat$ ) camphor1 only #bb p] c5t4 di$4 ,he reports temp]ature fall+ by lysis :5 camphor is us$1 & comm5ts on ! symptomatic improvem5t foll[+ its use4 ,) ! great v>iation 9 ! cl9ical c\rse ( pneumonia1 ! above figures1 ?\gh sugge/ive1 c]ta9ly ne$ fur!r support be=e ! r\t9e use ( camphor z recomm5d$ by ,seib]t c be sanction$4 ,lat] articles f\nd on ! subject ref] to x 9 a v cursory way1 giv+ no protocols & no cases1 & giv+ ! ref]ee ! feel+ t ! conclusions 7 v impressioni/ic4 ,r,,sum ,aft] a c>eful se>* ( ! lit]ature1 ! ref]ee concludes t3 ,huge doses ( camphor1 to #bej gra9s 9 tw5ty-f\r h\rs1 may be giv5 to man )\t s]i\s results4 ,no satisfactory evid5ce1 h[ev]1 appe>s t camphor has a specific g]micidal action on pneumococci 7simil> to t ( e?ylhydrocupre974 ,! cl9ical evid5ce1 z f\nd 9 ! lit]ature1 is c]ta9ly ( v little value4 ,x appe>s t ! sale ( a simple solution ( camphor 9 oil "u ! guise ( 8,anti-,pneumococcic ,oil0 is to be deplor$ 7a #bj p] c5t4 solution ( camphor 9 cottonse$ oil is (ficial 9 ! ,u4 ,s4 ,ph>macopeia z camphor l9im5t74 ,x is recomm5d$ t ! prep>ation be held inadmissible to ,new & ,non(ficial ,rem$ies because exagg]at$ !rapeutic claims are advanc$ = x1 & because ! "n is n descriptive ( ! composition1 b is1 in/ead1 !rapeutically sugge/ive4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #c1 #aibj47 ,,dial 8,,ciba0 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,dial 8,ciba0 has n be5 accept$ = 8,new & ,non(ficial ,rem$ies0 because1 z ! report :i* foll[s %[s1 unw>rant$ claims are made = ! product4 ,x is a def9ite new *emical comp\nd :i* might be made eligible = ,n4 ,n4 ,r4 if mislead+ !rapeutic claims 7 elim9at$4 ,! ,c\ncil direct$ t ,dial 8,ciba0 be includ$ ) ,articles ,describ$ b ,n ,accept$1 s t physicians might be in=m$ ) reg>d to its "* & prop]ties4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,dial 8,ciba0 is a hypnotic manufactur$ by ! ,society ( ,*emical ,indu/ry ( ,basle1 ,switz]l&1 & is sold 9 ! ,unit$ ,/ates by ,a4 ,klip/e9 & ,company1 ,inc41 ,new ,york4 ,*emically1 ,dial 8,ciba0 is diallylb>bituric acid & is1 !re=e1 closely relat$ to die?ylb>bituric acid or b>bital 78v]onal074 ,! claims made = ,dial 8,ciba0 are 7#a71 t ! 8allyl0 gr\p 9 its molecule makes x m readily decompos$ by oxidiz+ ag5ts ?an b>bital1 :i* conta9s ! 8e?yl0 gr\p2 7#b7 t because ( ?is ease ( oxidation1 x is m readily decompos$ 9 ! body & m rapidly & completely elim9at$1 & 7#c7 t because ( its alleg$ rapid elim9ation1 x is devoid ( ! aft] effects ( b>bital & o!r hypnotics4 ,! ,c\ncil took up ! sub/ance 9 ,febru>y1 #aiah1 & ref]r$ ! matt] to ! ref]ee 9 *>ge ( b>bital prep>ations4 ,! ref]ee consid]$ unw>rant$ ! claim t ,dial 8,ciba0 did n h ! aft]-effects ( o!r hypnotics due to its alleg$ total decomposition 9 ! body4 ,! ,am]ican ag5ts1 ,a4 ,klip/e9 & ,company1 7 in=m$ ( ! ref]ee's objections4 ,_! att5tion 0 also call$ to ! fact t1 not)/&+ ! claim$ abs5ce ( aft]-effects 9 "o "p ( ! adv]tis+1 o!r p>ts ( ! same adv]tis+ admitt$ c]ta9 po/-hypnotic effects ( ! product4 ,x 0 po9t$ out also t :ile x 0 claim$ 9 "o ( ! adv]tis+ circul>s t l[]+ ( ! blood pressure is nev] obs]v$ aft] adm9i/ration ( ,dial 8,ciba10 yet two ( ! au?ors quot$ 9 ! same circul> def9itely /at$ t a l[]+ ( ! blood pressure foll[$ ev5 small doses ( ! drug & ^! au?ors w>n aga9/ ?is v dang] 9 c]ta9 conditions4 ,a ye> lat]1 a circul> lett] s5t out by ,a4 ,klip/e9 & ,company reit]at$ ! claim t ! ass]t$ decomposition ( ,dial 8,ciba0 9 ! body prev5ts aft]-effects1 ! drug be+ /ill contra/$ ) b>bital 78v]onal074 ,9 view ( ! reit]ation ( ?is highly improbable claim1 ! ref]ee und]took to /udy ! comp>ative action ( ,dial 8,ciba0 z comp>$ ) o!r hypnotics4 ,x 0 f\nd t ! actions ( ,dial 8,ciba0 are n di/+ui%able1 qualitatively1 f ^? ( b>bital1 !re be+ no p]ceptible diff]5ce 9 ! aft]-effects or 9 ! nature ( ! side actions4 ,9 toxic doses1 bo? caus$ pr(\nd depression ) ! temp]ature fall+ to t ( ! room 7or ab\t "o degree above71 ! respiration be+ extraord9>ily sl[ & %all[ z "o w\ld expect ) l[]+ ( ! temp]ature4 ,!re 7 also ! same evid5ces ( nausea t are s frequ5tly se5 aft] toxic doses ( ! v>i\s hypnotics ( ?is gr\p4 ,9 view ( ^! results1 ! ,c\ncil decl>$ t x is unw>rant$ to claim fre$om f aft]-effects = ,dial 8,ciba40 ,! ,c\ncil held t ! foll[+ /atem5t is unw>rant$3 8,! !rapeutic field = ,dial #8,ciba1' z %[n by te/s on rabbits1 is j z broad z ! field = ,die?ylb>bituric ,acid40 ,te/s on rabbits d n & _c %[ ! bread? ( ! !rapeutic field = a hypnotic4 ,! ,c\ncil also decl>$ ! foll[+ /atem5t improbable1 & contr>y to ! evid5ce obta9$ by ! ref]ee3 8,9 dogs1 ! increase ( dosage beyond ! !rapeutic dose to ! po9t ( dea? is decid$ly 9 favor ( ,dial #8,ciba1' :i* requir$ a l>g] dose ?an die?ylb>bituric acid to produce dea?40 ,! ref]ee's exp]im5ts on cats %[ t ,dial 8,ciba0 is sev]al times z toxic z hydrat$ *loral1 & m ?an twice z toxic z die?ylb>bituric acid 7b>bital74 ,s9ce ! circul> to :i* objection 0 made 9 #aiah 0 /ill be+ s5t out 9 ,decemb]1 #aiai1 ! ,c\ncil held ,dial 8,ciba0 inadmissible to ,n4 ,n4 ,r4 & vot$ t report ( its action 9 ! matt] be au?oriz$ = publication4 ,! ,c\ncil fur!r direct$ t ,dial 8,ciba0 be includ$ ) ,articles ,describ$ b ,n ,accept$4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #bd1 #aibj47 ,,apo!s9e ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,apo!s9e is a syn!tic drug = produc+ local ane/hesia1 made by ,p>ke1 ,davis ,company4 ,9 ! fall ( #aiag ! ,c\ncil wrote to ,p>ke1 ,davis ,company (f]+ its aid 9 e/abli%+ ! id5tity1 purity & !rapeutic effici5cy ( ?is syn!tic local ane/hetic ) ! ultimate object ( accept+ ! product = inclusion 9 ,new & ,non(ficial ,rem$ies %\ld ! facts w>rant su* acceptance4 ,! ,c\ncil's lett] 0 nev] ackn[l$g$4 ,aft] ,apo!s9e 0 put on ! m>ket ! ,c\ncil desir$ to accept x = inclusion 9 ,new & ,non(ficial ,rem$ies b1 un=tunately1 0 unable to d s because "s ( ! claims made = ! product 7 n ju/ifi$ by acceptable evid5ce4 ,! manufactur]s 7 notifi$ ( ! ,c\ncil's desire to admit ?is product to ,n4 ,n4 ,r4 & ! wi% 0 express$ t ! company w\ld ei!r s modify its claims z to make ! product acceptable "u ! ,c\ncil's rules or else w\ld submit evid5ce to ! ,c\ncil 9 pro( ( ! claims made & ?us p]mit ! ,c\ncil to revise its conclusions4 ,p>ke1 ,davis ,company 71 app>5tly1 ei!r unwill+ or unable to submit evid5ce t w\ld su/a9 _! claims2 nei!r did !y (f] to modify ! claims !mselves4 ,! product1 !re=e1 is ineligible to inclusion 9 ,new & ,non(ficial ,rem$ies2 x w1 h[ev]1 be li/$ 9 ! 8,describ$ ,b ,n ,accept$0 dep>tm5t ( ,new & ,non(ficial ,rem$ies4 ,! report on ,apo!s9e t foll[s has be5 au?oriz$ = publication4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,apo!s9e1 8! hydro*lorid ( die?yl-am9o-propyl-c9namate10 is an effici5t local ane/hetic4 ,x belongs to ! proca9 r ?an to ! coca9 type1 t is1 x belongs to t type :i*1 :ile effective = injection ane/hesia 7especially :5 comb9$ ) ep9ephr97 is relatively ineffici5t :5 appli$ to muc\s membranes4 ,apo!s9e may also be us$ = sp9al ane/hesia4 ,its absolute toxicity is less ?an t ( coca9 7z #bj is to #ae1 see table bel[7 b ab\t twice t ( proca9 7z #bj is to #dj1 see table bel[74 ,x is non-irritant1 is easily soluble & makes a /able solution s t x may readily be /]iliz$4 ,! ,c\ncil took exception to c]ta9 claims made by ,p>ke1 ,davis ,company = _! product on ! gr\nd t ^! claims 7 n support$ by acceptable sci5tific evid5ce4 ,"o ( ! claims 0 t ,apo!s9e is applicable 9 any case 9 :i* any o!r local ane/hetic is us$4 ,?is /atem5t1 made 9 _m adv]tisem5ts1 is di/9ctly mislead+ z us$4 ,:5 appli$ to muc\s membranes ,apo!s9e is f> inf]ior to coca9 & to "s o!r local ane/hetics1 yet ! claim obvi\sly sugge/s t ,apo!s9e is an effici5t sub/itute = any local ane/hetic4 ,! manufactur]s claim$1 too1 t ,apo!s9e is z pot5t z coca94 ,! claim w\ld lead ! physician to ?9k t ,apo!s9e _h ! same ane/hetic pot5cy z coca9 9 solution ( equal /r5g?4 ,?is /atem5t1 s f> z x ref]s to ! drug :5 appli$ to muc\s membranes1 is n 9 accord ) ! facts & is true = injection ane/hesia only :5 /rong] solutions are us$4 ,! only support = ! claim ( equal effici5cy appe>s to be ! exp]im5ts ) intracutane\s injections made by ,h4 ,c4 ,hamilton#acj 9 ,p>ke1 ,davis ,company's laboratory4 ,^! diff]$ consid]ably f ! results ( ,sollmann4#aca ,a fur!r s]ies ( exp]im5ts 7 made by ,sollmann to comp>e /ill fur!r ! div]se results previ\sly report$ by him & ,hamilton4 ,! late/ s]ies1 :ile %[+ consid]able v>iations 9 ! susceptibility ( diff]5t sk9 areas1 especially t[>d ,apo!s9e1 demon/rat$ 9 e case t ! effici5cy ( ,apo!s9e is unmi/akably l[] ?an t ( coca91 be+ at be/ "o half4 ,! s]ies also %[$ t ! pot5cy ( ,apo!s9e 0 nev] great] ?an proca9 & av]ag$ consid]ably bel[ x4 #acj ,! ,comp>ative ,values ( ,"s ,local ,ane/hetics by ,h4 ,c4 ,hamilton1 ,detroit1 ,mi*41 f ! ,rese>* ,laboratory ( ,p>ke1 ,davis ,co41 ,j4 ,lab4 ,cl94 ,m4 #d3fj 7,nov47 #aiah4 #aca ,comp>ative ,effici5cy ( ,local ,ane/hetics1 ,v1 by ,t4 ,sollmann1 f ! ,ph>macological ,laboratory ( ! ,s*ool ( ,m$ic9e1 ,we/]n ,res]ve ,univ]sity1 ,j4 ,ph>macol4 ,exp]4 ,!rap4 #aa3fi 7,feb47 #aiah4 ,ano!r claim made = ,apo!s9e :i* ! ,c\ncil holds is n support$ by evid5ce is t ( sup]ior safety4 ,?is claim is made on ! basis ( hypod]mic injections 9 gu9ea-pigs c>ri$ out 9 ! laboratory ( ,p>ke1 ,davis ,company4 ,su* exp]im5ts prove little because ( ! fact--well kn[n to laboratory work]s--t ! use ( rod5ts 9 toxicity te/s made by inject+ a drug into ! subcutane\s tissues does n give a reliable index ( ! relative toxicity ( su* a drug = man4 ,?is is due p>tly to ! peculi> resi/ance ( rod5ts to poisons & p>tly to ! great importance ( ! rate ( absorption4 ,! organism de/roys mo/ local ane/hetics s rapidly t ! rate ( absorption is m important ?an ! absolute dose4 ,! absorption f hypod]mic injections into gu9ea-pigs diff]s1 ( c\rse1 f t 9 cl9ical accid5ts1 especially :]e ! drug has be5 appli$ to muc\s membranes4 ,"o _c1 !re=e1 reliably e/imate ! degree ( cl9ical dang] on animals4 ,x has be5 %[n t :5 toxicity te/s ( local ane/hetics are made on cats ^! animals seem to respond to ! drugs 9 a mann] m closely approximat+ humans & x is a sugge/ive fact t ! m toxic ( local ane/hetics1 z %[n by te/s on cats1 h be5 f\nd ! mo/ dang]\s 9 cl9ical use4 ,! absolute toxicity ( ,apo!s9e has be5 measur$ by ,eggle/on & ,hat*]#acb by ! intrav5\s injection 9 cats4 ,! fatal doses1 9 t]ms ( milligrams p] kilogram rang$ z foll[s3 ,alyp91 ,holoca9 #aj ,beta ,euca9 #ab4e ,coca9 #ae ,apo!s9e #bj ,tropacoca9 #bj-be ,/ova9 #be-cj ,nirvan9 #cj-ce ,proca9 #dj-de #acb ,a ,fur!r ,contribution to ! ,ph>macology ( ! ,local ,ane/hetics by ,eggle/on & ,hat*]1 f ! ,dep>tm5t ( ,ph>macology1 ,cornell ,univ]sity ,m$ical ,college1 ,new ,york ,city1 ,j4 ,ph>macol4 ,exp]4 ,!rap4 #ac3dcc 7,aug47 #aiai4 ,! absolute toxicity ( ,apo!s9e is1 !re=e1 only a little l[] ?an t ( coca91 & is twice z great z t ( proca94 ,! cl9ical dang]s _c be pr$ict$ by ei!r me?od1 s9ce cl9ical accid5ts dep5d1 9 mo/ in/ances1 on idiosyncrasies1 or ! te*nic ( application4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #bd1 #aibj47 ,,eumict9e ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has adopt$ & au?oriz$ publication ( ! report :i* appe>s bel[4 ,?is report decl>es 8,eumict9e0 ineligible = ,new & ,non(ficial ,rem$ies because 7#a7 x conflicts ) ,rule #aj 9 t x is unsci5tific1 7#b7 x conflicts ) ,rule #f 9 t x is sold "u unw>rant$ !rapeutic claims1 7#c7 x conflicts ) ,rule #d aga9/ indirect adv]tis+ to ! public 9 t ! "n 8,eumict9e0 is bl[n 9 ! bottle = ! obvi\s purpose ( br++ ! product to ! att5tion ( ! public :5 x is prescrib$ 9 ! orig9al package1 & 7#d7 because ! "n is !rapeutically sugge/ive & n 9 any way descriptive ( its composition4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,eumict9e is a prep>ation f ! laboratory ( ,maurice ,le ,pr9ce1 ,p>is1 ,france1 & is m>ket$ 9 ?is c\ntry by ,george ,j4 ,wallau1 ,inc41 ,new ,york4 ,x is claim$ t ! product is 8a balsamo-antiseptic prep>ation compos$ ( ,santalol1 ,salol1 & ,hexame?yl5e-,tetram9e1 9 ! =m ( glut5-coat$ capsules40 ,n[h]e 9 ! adv]tis+ are ! am\nts ( ! +r$i5ts giv54 ,accord+ to ! ,am]ican ag5t1 h[ev]1 8ea* capsule is suppos$ to conta9 #bj c5tigrams ( ,santalol1 #e c5tigrams ( ,salol1 #e c5tigrams ( ,hexame?yl5e-,tetram9e40 ,eumict9e is advis$ 89 treat+ g5ito-ur9>y diseases 7ure?ritis1 cy/itis1 pro/atitis1 pyelitis1 etc4740 ,x is claim$ to be 8bo? an antiphlogi/ic modify+ ag5t1 a well-tol]at$ diuretic0 :i* 8may be adm9i/]$ = long p]iods )\t ill effects40 ,! ,c\ncil decl>es ,eumict9e ineligible = ,new & ,non(ficial ,rem$ies because x is exploit$ 9 conflict ) ! foll[+ rules3 ,x is unsci5tific 7,rule #aj74 ,eumict9e is compos$ ( hexame?yl5am91 salol & sanalol 9 fix$ proportions4 ,hexame?yl5am9 may s]ve a useful purpose 9 "s =ms ( infection ( ! ur9>y tract1 b nei!r x nor salol is ( any consid]able value 9 gonorrhea4 ,x is n[ kn[n t ! balsamic prep>ations1 =m]ly s widely us$1 d n h ! curative effects 9 gonorrhea & associat$ conditions t us$ to be ascrib$ to !m4 ,to comb9e ?ree sub/ances1 none ( :i* has any di/9ct !rapeutic value 9 ! conditions = :i* ,eumict9e is propos$1 does n enhance _! value4 ,!re is no?+ orig9al 9 ! comb9ation us$ 9 ,eumict9e1 or 9 ! mann] ( disp5s+ x4 ,x is sold "u unw>rant$ !rapeutic claims 7,rule #f74 ,^! claims are made n only = ! compon5ts ( ,eumict9e b = ! comb9ation itself4 ,?\gh santalol has c]ta9 advantages ov] ! some:at v>iable oil ( santal & o!r balsamic res9s1 x is n true t santalol 8does n cause conge/ion ( ! r5al epi!lium0 or t x does n 8produce exan!ma z d copaiba1 cubebs1 & ! ord9>y santal oil40 ,x is n true t salol is 8devoid ( toxicity40 ,nei!r is x correct to say t salol 8asepticizes & dis9fects ! bladd]1 ! pro/ate & ! ure?ra40 ,! claim t hexame?yl5am9 8is ( value :5 any acute symptoms or t5d5cy to inflammation subsi/0 is n ju/ifi$4 ,! claim t hexame?yl5am9 8r5d]s soluble ! uric acid & urates0 is also )\t f\ndation4 ,! foll[+ p>agraph is *>act]i/ic ( ! claims made = ,eumict9e3 8,anti-gonorrhoic by its ,santalol1 diuretic1 urolytic & analgetic by its hexame?yl5etetram9 7,urotrop97 antiseptic & antipyretic by its ,salol1 ,eumict9e repres5ts a real !rapeutic advance 9 ! sci5tific treatm5t ( diseases ( ! ur9>y passages40 ,in/ead ( be+ 8a real !rapeutic advance0 9 ! treatm5t ( diseases ( ! ur9>y passages1 ,eumict9e pres5ts "o ( ! complex comb9ations t h long ret>d$ ! sci5tific treatm5t ( ^! diseases4 ,eumict9e also conflicts ) ,rules #d & #h ( ! ,c\ncil4--7,f ,! ,j\rnal ,a4 ,m4 ,a4 ,feb4 #ba1 #aibj47 ,,platt',s ,,*lorides ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has au?oriz$ publication ( ! foll[+ report on 8,platt's ,*lorides40 ,x also decl>es ! prep>ation inadmissible to ,new & ,non(ficial ,rem$ies because its composition is unc]ta9 & indef9ite & because ! claims made = x are exagg]at$ & mislead+4 ,w4 ,a4 ,puckn]1 ,secret>y 8,platt's ,*lorides10 m>ket$ by ,h5ry ,b4 ,platt1 ,new ,york1 is sold z a dis9fectant & g]micide4 ,only incomplete & contradictory /atem5ts h be5 made 9 reg>d to its composition4 ,_m ye>s ago 7ab\t #ahii7 ! composition ( ,platt's ,*lorides 0 giv5 z 8,! ,*lorids ( ,zn #dj p] c5t41 ,pb #bj1 ,ca #ae1 ,al #ae1 ,mg #e1 ,k #e40 ,! /atem5t t ! prep>ation conta9$ #bj p] c5t4 ( lead *lorid is int]e/+1 9 view ( ! fact t lead *lorid is soluble 9 wat] at ord9>y temp]atures to ! ext5t ( less ?an #a p] c5t4 ,9 a booklet1 also issu$ a numb] ( ye>s ago1 ! foll[+ 8,=mula ( ,platt's ,*lorides0 0 giv53 8,a saturat$ solution ( ,metallic ,*lorids comb9$ 9 ! foll[+ proportions3 8,sol4 ,z9c ,*lorid #dj p] c5t4 8,sol4 ,alum9um ,*lorid #ae p] c5t4 8,sol4 ,lead ,*lorid #bj p] c5t4 8,sol4 ,calcium ,*lorid #ae p] c5t4 8,sol4 ,magnesium ,*lorid #e p] c5t4 8,sol4 ,potassium ,*lorid #e p] c5t40 ,! label on a bottle pur*as$ 9 #aiaa1 describes ,platt's ,*lorides z3 8,a ,highly ,conc5trat$ ,solution ( ! ,*lorids ( ,alum9um1 ,calcium1 ,lead1 ,z9c1 etc40 ,! label ( a bottle pur*as$ 9 #aiai reads3 8,conta9s ,in]t ,mat]ial3 ,wat] #hd4j4 ,sodium ,*lorid #d4h4 ,calcium ,*lorid #j4c40 ,?is /atem5t is obvi\sly made to meet ! requirem5ts ( ! f$]al ,insecticide ,act4 ,?is law requires ei!r t ! id5tity & ! am\nts ( pot5t +r$i5ts 9 dis9fect+ prep>ations be decl>$ or else t ! p]c5tage ( ! in]t +r$i5ts ( su* prep>ations be giv54 ,! omission f ! label ( all /atem5ts ) reg>d to ! pot5t +r$i5ts ( ! prep>ation & ! abs5ce ( su* a /atem5t 9 rec5t adv]tis+ matt] sugge/s ei!r t ! old] /atem5ts ab\t its composition 7 false or else t ! composition has be5 *ang$4 ,ts*eppe publi%$ 7,ph>maceutis*e ,runds*au #h3aji1 #ahij7 an analysis ( ,platt's ,*lorides :i* has be5 quot$ 9 o!r publications z indicat+ ! composition ( ! prep>ation4 ,he report$ t he f\nd ea* qu>t ( ! prep>ation to conta9 alum9um sulphate #f ounces1 z9c *lorid #a-a_/c ounces1 sodium *lorid #b ounces1 calcium *lorid #c ounces4 ,"s ye>s ago 7ab\t #aiaa7 ! company made ! foll[+ /atem5t relative to ! g]micidal p[] 7ph5ol co-effici5t7 ( ,platt's ,*lorides3 8444 = "s "t ! c>bolic acid co-effici5cy ( our output has be5 f #b4e to #d4c1 ! av]age be+ ab\t #c2 namely ab\t ?ree times /rong] ?an pure c>bolic acid40 ,9 #aiab1 ! ,u4 ,s4 ,public ,heal? & ,m>9e ,hospital ,s]vice report$ 7,bullet9 #hb1 ,public ,heal? & ,m>9e ,hospital ,s]vice1 p4 #fi7 t ! ph5ol coeffici5t ( a sample ( ,platt's ,*lorides 0 s l[ t x c\ld n be det]m9$ & also t ! sample 0 f\nd to conta9 "s m]curic *lorid4 ,9 #aiac1 ! ,nor? ,dakota ,agricultural ,exp]im5t ,/ation report$ 7,bullet91 ,july1 #aiac1 p4 #bib71 t ,platt's ,*lorides conta9$ pr9cipally z9c *lorid1 also "s alum9um *lorid1 calcium *lorid1 & traces ( m]curic *lorid4 ,! ph5ol coeffici5t1 det]m9$ by ! ,hygi5ic ,laboratory me?od1 0 f\nd to be #j4je4 ,! prec$+ sugge/s t ! composition ( ,platt's ,*lorides _h be5 *ang$ 7)\t notice to ! consum]7 & t x _h be5 =tifi$ by ! addition ( m]curic *lorid4 ,ye>s ago "p ( ! adv]tis+ ( ?is product 0 a te/imonial f a heal? (ficial :i* decl>$ t1 = dis9fection1 8bi*lorid ( m]cury is useless 9 dis9fect+ sputum or dis*>ges f ! b[els1 be+ r5d]$ in]t by ! album9 pres5t0 & x laud$ ,platt's ,*lorides z devoid ( su* drawbacks4 ,,rec5t ,,analyses ,,( ,,platt',s ,,*lorides ,to det]m9e ! pres5t composition ( ,platt's ,*lorides & to comp>e x ) t sold =m]ly1 ! ,a4 ,m4 ,a4 ,*emical ,laboratory has made an analysis ( a specim5 pur*as$ 9 #aiai & also ( "o pur*as$ 9 #aiaa & s9ce kept unop5$ 9 ! files ( ! ,c\ncil on ,ph>macy & ,*emi/ry4 ,! foll[+ table conta9s ! results ( ^! analyses 7all quantities giv5 are ,gm4 p] #ajj c4c473 #aiaa ,,specim5 #aiai ,,specim5 ,color ,colorless ,/raw ,color ,odor ,none ,none ,specific ,gravity at #be ,cc4 #a4abbi #a4acac ,total ,solids 7residue at #ajj ,cc47 #af4di #ah4cc ,*lorid 7,cl-7 #g4fj #aj4gd ,sulphate 7,,s--7 #a4aa 4#af ,alum9um 7,al7 4#bb 4#ij ,calcium 7,ca7 4#ai 4#ac ,z9c 7,zn7 #e4aa #c4ic ,lead 7,pb7 4#jdf ,traces ,m]cury 7,hg7 44 4#jjhf ,sodium 7,na7 #a4ja #a4ci ,^! quantities transpos$ to hypo!tical comb9ations w\ld indicate t ,platt's ,*lorides has ! foll[+ composition3 #aiaa ,specim5 #aiai ,specim5 ,alum9um ,sulphate #a4cb 4#ah ,alum9um ,*lorid 4#jg #d4bi ,calcium ,*lorid 4#ed 4#cg ,z9c ,*lorid #aj4ff #h4ai ,lead ,*lorid 4#jf ,traces ,m]cury ,*lorid 44 4#jaaf ,sodium ,*lorid #b4eg #d4ha ,hydrog5 ,*lorid 4#dc ,none ,9 ! pa/1 ! adv]tis+ has sugge/$1 m or less directly1 t1 z *lor9at$ lime 7blea*+ p[d]7 may be made to give (f *lor9 gas :i* dis9fects1 s ! air 9 a room may be dis9fect$ by evaporat+ ,platt's ,*lorides4 ,?us ! label ( ! #aiaa specim5 conta9s ! foll[+3 8,,= ,,/ore ,,rooms1 ,refrig]ators1 & ,closets1 keep a sponge saturat$ ) ! pure liquid 9 a sauc] on an upp] %elf40 ,on ! label ( ! #aiai specim51 ! /atem5t reads3 8,,refrig]ators ,,& ,,/or]ooms--,z a dis9fectant wa% regul>ly ) "o "p ,*lorides to eight ( wat]4 ,z a deodorant1 keep 9 an op5 vessel a sponge or clo? saturat$ ) ! ,*lorides full /r5g?40 ,t ! own] ( ,platt's ,*lorides really believes t ! vapors ( ! prep>ation h dis9fect+ prop]ties is se5 f a lett] ov] ! "n ( ,h5ry ,b4 ,platt pr9t$ 9 ! ,new ,york ,tribune 9 #aiaf4 ,?is read1 9 "p3 8444 by keep+ 9 a di% or sauc] on radiators ,platt's ,*lorides dilut$ "o-half1 ! hot solution w evaporate & purify ! air1 ?us de/roy+ ! grip g]m :i* is ! cause ( all ! tr\ble40 ,f ! analysis ( ,platt's ,*lorides1 x is evid5t t :5 ! prep>ation is evaporat$1 wat] vapor only escapes4#acc ,:atev] dis9fect+ or g]micidal action ! prep>ation may possess is ex]cis$ only :5 ! solution is br\ght 9 direct contact ) ! sub/ance to be dis9fect$4 #acc ,x is well kn[n t :5 a solution ( m]curic *lorid 9 wat] is evaporat$1 m]curic *lorid passes (f ) ! wat] vapors1 b "u any condition ! am\nt is b a fraction ( ! :ole4 ,z 9 ,platt's ,*lorides o!r metallic *lorids are pres5t1 ! =mation ( complex m]curic comp\nds :i* is b\nd to h occurr$1 %\ld ret>d or prev5t ! volatilization ( m]curic *lorid4 ,t ?is actually occurs 0 confirm$ by ! foll[+ exp]im5t3 ,:5 #a gm4 m]curic *lorid 0 dissolv$ 9 #a lit] ( wat] & ! solution di/ill$1 ! di/illate conta9$ a v small am\nt ( m]cury4 ,!n ! exp]im5t 0 repeat$ aft] add+ sodium *lorid to ! solution to simulate ! conditions 9 ,platt's ,*lorides4 ,9 ?is case no m]cury 0 f\nd 9 ! di/illate4 ,ev5 7 all ! m]cury 9 a bottle ( ,platt's ,*lorides volatiliz$ 9 a room #aj by #ab by #i feet1 ?is w\ld be equival5t to only ab\t #a_/ejj gra9 m]curic *lorid p] cubic foot4 ,! alum9um & z9c salts pres5t may be useful z deodorants b !y are n effective z g]micides4 ,! pres5ce ( m]curic *lorid 9 a conc5tration ( #a to #aj1jjj is h>dly to be consid]$ z mat]ially increas+ ! effici5cy4 ,! directions recomm5d ! use ( a mixture ( #a "p ( ,platt's ,*lorides to #aj p>ts ( wat] = r9s+ ! h&s1 & a mixture ( #a "p to #d p>ts ( wat] = ! dis9fection ( dis*>ges4 ,x is fur!r /at$ t #a qu>t makes #b gallons suffici5tly /rong = g5]al use4 ,x is evid5t t su* dilutions decrease consid]ably ! feeble g]micidal action ( ! orig9al fluid4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,m>* #bg1 #aibj47 ,,anti-,,tub]cul\s ,,lymph ,,comp\nd 7,,swe5y7 ,,& ,,anti-,,syphilitic ,,comp\nd 7,,swe5y7 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has au?oriz$ publication ( ! reports :i* appe> bel[1 decl>+ ,anti-,tub]cul\s ,lymph ,comp\nd 7,swe5y7 & ,anti-,syphilitic ,comp\nd 7,swe5y7 ineligible = ,new & ,non(ficial ,rem$ies4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,anti-,tub]cul\s ,lymph ,comp\nd 7,swe5y7 8,anti-,tub]cul\s ,lymph ,comp\nd 7,swe5y70 is put out by ! ,national ,laboratories ( ,pittsburgh1 ,dr4 ,gilli=d ,b4 ,swe5y1 8,m$ical ,director40 ,swe5y has claim$ at diff]5t times t he became int]e/$ 9 ! subject ( von ,behr+'s ef=ts to immunize cattle to tub]culosis at a "t :5 he 0 an assi/ant 9 von ,behr+'s laboratory4 ,he claims to h conceiv$ ! idea :ile !re ( transf]r+ bov9e immunity to tub]culosis to ! human subject & lat] to h evolv$ 8 8treatm5t0 at ! ,pa/eur ,in/itute 9 ,p>is4 ,j h[ ,anti-,tub]cul\s ,lymph ,comp\nd is made today is n /at$--at lea/ s f> z "o is able to le>n f rec5t adv]tis+4 ,"s ye>s ago ,swe5y decl>$ t 8 8,anti-,tub]cul> ,lymph0 7z x 0 !n call$7 0 d]iv$ f a bullock :i* _h be5 immuniz$ to tub]culosis4 ,!n3 8,! immuniz$ animal hav+ be5 slaught]$1 ! cont5ts ( ! lymph res]voirs are c>efully collect$ & an aque\s extract is made f ! grey c]ebral sub/ance1 sp9al cord & ! lymph gl&s4 ,x is !n filt]$ "u high pressure & de-album9iz$ by succussion4 ,to ?is1 ! lymph1 toge!r ) a def9ite proportion 7#ej p] c5t471 ( ! naturally phosphoriz$ bra9 fats is add$1 ) a small am\nt ( *loride ( gold 7ab\t #a-fj gr4 to ! dose71 ! latt] z a pres]vative40 ,x is a fair assumption t h[ev] ! prep>ation may h be5 made orig9ally1 x is n n[ made 9 su* a mann] z to br+ x "u ! f$]al laws gov]n+ ! prep>ation ( s]ums & simil> prep>ations4 ,! claims made = ,anti-,tub]cul\s ,lymph ,comp\nd are ( ! usual uncritical & unsci5tific type4 ,ma9ly1 ( c\rse1 !y are ( ! te/imonial class4 ,! physician is told t ! prep>ation has be5 c>efully te/$ by m5 ^: judgm5t is wor?y ( consid]ation2 t ! v]dict has be5 altoge!r favorable to ! 8,comp\nd40 ,?us3 8444 ! rem$y 0 submitt$ to a select$ body ( skill$ physicians1 recogniz$ = _! skill & c>e 9 mak+ !rapeutic obs]vations4 ,^! m5 repres5t$ widely v>y+ conditions1 climatic & o!rwise4 ,^? :o said t5 ye>s ago t ,anti-,tub]cul\s ,lymph ,comp\nd has a specific immuniz+ influ5ce ^u ! tub]culosis pati5t1 f9d ! same to be true today40 ,c>eful read+ ( ! matt] j quot$ w reveal its ambiguity & inh]5t lack ( frankness4 ,! inf]5ce convey$ is t ! 8select$ body ( skill$ physicians0 h unqualifi$ly endors$ ,anti-,tub]cul\s ,lymph ,comp\nd 7,swe5y7--b x does n say s6 ,x is ! hi/ory ( all su* prep>ations1 introduc$ to ! m$ical pr(ession ) ! usual bl>e ( trumpets1 t a c]ta9 numb] ( favorable te/imonials c be obta9$4 ,x is also ! hi/ory ( su* products t "o has b to wait a few ye>s & ! physicians :o _h writt5 mo/ en?usia/ically reg>d+ ! prep>ation--9 ! fir/ flu% ( _! optimism foll[+ its use & ! p]usal ( ! manufactur]s' lit]ature--w ackn[l$ge t !y 7 mi/ak5 9 _! orig9al e/imate & are no long] us+ ! ag5t4 ,9 ?is connection an inve/igation ( "s ( ! old te/imonials = ,anti-,tub]cul\s ,lymph ,comp\nd by ! ,propag&a dep>tm5t ( ,! ,j\rnal is in/ructive4 ,9 a some:at elaborate booklet publi%$ 9 #aijg by ,swe5y1 an ,indiana physician 0 said to h report$ favorable results foll[+ ! adm9i/ration ( ! 8lymph40 ,a lett] writt5 to ?is physician 9 ,octob]1 #aiai1 ask+ = 8 pres5t op9ion on ! product br\ght ?is reply1 9 "p3 8444 x be+ twelve ye>s s9ce us+ ! s]um & no ref]5ce or repeat$ ord]s s9ce %\ld surely suffice z evid5ce ( my lack ( fai? 9 ! s]um44440 ,an ,ill9ois physician 0 report$ 9 ! same booklet to h describ$ a case ( a "y man ) an active tub]culosis1 :o 0 giv5 injections ( ! 8lymph0 9 ,febru>y1 #aijg4 ,! pati5t1 x 0 claim$1 %[$ imm$iate improvem5t & ! ,swe5y booklet 7publi%$ 9 ,augu/1 #aijg7 /at$ t 8improvem5t 9 ?is case cont9u$ & t]m9at$ 9 complete recov]y40 ,a lett] writt5 to ! physician 9 ,octob]1 #aiai1 br\ght out ! fact t ! "y man 9 "q1 aft] receiv+ 8,anti-,tub]cul\s ,lymph ,comp\nd0 & o!r treatm5t 0 remov$ 8on a /ret*]0 8to ,new ,mexico1 :]e he rema9$ = ?ree or f\r ye>s0 & recov]$4 ,! doctor adds3 8,i d n ?9k t ! ,anti-,tub]cul\s ,lymph _h any?+ to d ) ! man's recov]y1 al?\gh ,i realize ! difficulty ( def9itely analyz+ j :at did effect ! cure4 ,i did s9ce t "t use t prep>ation 9 sev]al o!r cases )\t b5eficial results s t ,i gave x up a good _m ye>s ago add+ x to t l>ge heap ( ph>maceutical mat]ial #8weigh$ & f\nd want+4'0 ,a physician 9 ,texas also report$ 9 ! #aijg booklet z hav+ _h v satisfactory results ) ! ,anti-,tub]cul\s ,lymph ,comp\nd 9 "o case ( pulmon>y tub]culosis 0 writt5 to 9 ,octob]1 #aiai4 ,he repli$3 8,i w /ate t subsequ5t use ( ?is comp\nd did n be> out ! app>5t good results f its use 9 ! fir/ case or two40 ,9 a 8,bullet90 issu$ by ! ,swe5y conc]n 9 #aiab1 a ,p5nsylvania physician 0 quot$ z hav+ treat$ ?ree cases ) ,anti-,tub]cul9 ,lymph ,comp\nd ) resultant cures4 ,?is physician 0 writt5 to 9 ,octob]1 #aiai1 & he repli$3 8,i h no k ( ! use ( my "n by any ,pittsburgh conc]n & "k no?+ ( a lymph ( ! "n ( ,swe5y2 nei!r d ,i recollect ev] cur+ ?ree cases ( tub]culosis ) any lymph40 ,! same 8,bullet90 quot$ ! alleg$ /atem5t by a ,delaw>e physician to ! effect t he believ$ ,anti-,tub]cul\s ,lymph ,comp\nd to be ! mo/ successful treatm5t ( tub]culosis extant4 ,?is 9 #aiab4 ,to an inquiry s5t 9 ,octob]1 #aiai1 ?is physician briefly repli$3 8,am n us+ x n[40 ,! result ( ! ,propag&a dep>tm5t's que/ionnaire 0 :at might h be5 expect$4 ,e physician :o answ]$ ! inquiry reg>d+ 8 previ\s & pres5t op9ions ( ,anti-,tub]cul\s ,lymph ,comp\nd 7,swe5y7 decl>$1 9 effect1 t he _h long s9ce ceas$ to h fai? 9 its value or efficacy4 ,accord+ to claims made 9 ,swe5y lit]ature1 8,anti-,tub]cul\s ,lymph ,comp\nd ex]cises its immuniz+ p[] ?r\gh a specific action ^u ! blood cells40 ,! /atem5t t 8x de/roys ! tub]culosis g]m :5 ?is is pres5t 9 ! sy/em ( ! pati5t0 is untrue4 ,! facts are1 no s]um or lymph has ?us f> be5 prov$ to h any value 9 ! treatm5t ( tub]culosis ev5 :5 =tifi$ by 8a small proportion ( *loride ( gold & soda0 z "o circul> tells u ! 8lymph0 is4 ,9 spite ( rese>* by compet5t inve/igators1 we are /ill )\t any aid 9 ! =m ( a s]um 9 ! treatm5t ( tub]culosis4 ,anti-,tub]cul\s ,lymph ,comp\nd 7,swe5y7 is "o ( ^? prep>ations t ne$ no elaborate laboratory te/s1 nor ev5 exact !rapeutic rese>*1 to conv9ce any cle>-?9k+ p]son t x is pat5tly & obvi\sly wor?less4 ,"o w\ld hesitate be=e ask+ any reputable cl9ician to te/ a prep>ation ( ?is sort4 ,x is a con/ant s\rce ( surprise t "s physicians all[ !mselves to be p]suad$ by adv]tis+ lit]ature t is obvi\sly uncritical & unsci5tific1 to use prep>ations :i* h no m reasonable f\ndation ?an ?is "o4 ,! ,c\ncil decl>es ,anti-,tub]cul\s ,lymph ,comp\nd 7,swe5y7 n acceptable = ,new & ,non(ficial ,rem$ies4 ,anti-,syphilitic ,comp\nd 7,swe5y7 ,?is prep>ation also is made by or "u ! direction ( ! same ,dr4 ,gilli=d ,b4 ,swe5y ^: rese>*es 787 l$ to ! production & evolution ( ! ,anti-,tub]cul\s ,lymph ,comp\nd 7,swe5y74 ,accord+ to ! data at h&1 ?is prep>ation is made by susp5d+ b5zoate ( m]cury 9 lymph f ! bullock4 ,case reports are giv5 ( alleg$ cures ( syphilis aft] two mon?s ( treatm5t2 inde$1 ! circul> exploit+ ! ag5t makes ! /atem5t t x is seldom necess>y to cont9ue ! treatm5t beyond two mon?s1 :i*1 if "o *ose to be cr$ul\s1 w\ld indicate extraord9>y p[] = ! m]cury4 ,m]cury ( c\rse has a prop] place 9 ! treatm5t ( syphilis1 b t any physician c\ld be induc$ to place 8 tru/ 9 ?is prep>ation is almo/ un?9kable ?\gh te/imonials--:i* ! 8,national ,laboratories0 claim to h receiv$ f physicians--are publi%$4 ,!y all /amp ! writ]s z n only gullible b also incompet5t4 ,! t5or ( ! claims is on a p> ) ^? made = ! ,anti-,tub]cul\s ,lymph ,comp\nd2 !y d n ju/ify ! "t requir$ = detail$ consid]ation4 ,! ,c\ncil decl>es ,anti-,syphilitic ,lymph ,comp\nd 7,swe5y7 n acceptable = ,n4 ,n4 ,r4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,april #c1 #aibj47 ,,syrup ,,lept9ol 7,,=m]ly ,,syrup ,,balsamea7 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has au?oriz$ publication ( ! foll[+ report on 8,syrup ,lept9ol0 7=m]ly 8,syrup ,balsamea074 ,! product is inadmissible to 8,new & ,non(ficial ,rem$ies10 fir/1 because ! manufactur]s fail to give ! pr(ession in=mation reg>d+ ei!r ! am\nt ( ! pot5t +r$i5t or ! me?od ( det]m9+ its id5tity & uni=mity2 second1 because ( ! unw>rant$ recomm5dation = its use 9 su* infecti\s diseases z pneumonia & epidemic influ5za & = lack ( satisfactory support+ evid5ce ( its alleg$ !rapeutic efficacy 9 o!r diseases &1 ?ird1 because ! recomm5dations = its use appe>+ on & 9 ! trade package con/itute an indirect adv]tisem5t to ! public4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,syrup ,lept9ol is sold by ! ,balsamea ,co4 ( ,san ,francisco4 ,x 0 fir/ introduc$ z ,syrup ,balsamea4 ,9 rec5t adv]tis+1 ,syrup ,lept9ol is also ref]r$ to simply z 8,lept9ol40 ,accord+ to ! /atem5ts ( ! ,balsamea ,co41 ,syrup ,lept9ol is prep>$ f ! root ( a species ( ,leptota5ia 7a plant belong+ to ! p>snip family7 :i* gr[s 9 ,nevada & :i* has h]et(ore n be5 us$ 9 m$ic9e4 ,! manufactur] /ates t ! botani/s :o h be5 consult$ h be5 unable to agree on ! botanical classification ( ! plant4 ,! dri$ root ( ?is unclassifi$ species ( ,leptota5ia is extract$ ) alcohol & f ! extract s obta9$ ! syrup is made1 b no in=mation has be5 furni%$ to %[ h[ ! alcohol-soluble mat]ial is incorporat$ 9 ! syrup4 ,fur!r1 ! manufactur] has n ann\nc$ te/s :]eby ! id5tity & uni=mity ( ! f9i%$ prep>ation may be det]m9$4 ,a booklet conta9s ! foll[+3 8,! species ( ,leptota5ia f :i* ,,lept9ol is produc$ 0 fir/ us$ 9 m$ic9e by ,dr4 ,e4 ,t4 ,krebs1 :o1 aft] ?or\gh laboratory inve/igation & cl9ical application ov] a p]iod ( sev]al mon?s1 :i* result$ 9 ! p]fect+ ( ,,lept9ol1 prescrib$ ! prep>ation = ,influ5za dur+ ! epidemic ( t disease 9 #aiah ) rem>kably good results4 ,s9ce ?is fir/ use1 ,,lept9ol has be5 exhau/ively te/$ by cl9icians 9 private practice & 9 hospitals 9 ! treatm5t ( ,pneumonia1 ,influ5za ,bron*itis1 etc41 & has be5 univ]sally endors$40 ,9 a circul> lett] x is ass]t$ t ! use ( 8,lept9ol0 dur+ ! 8influ5za epidemic0 ( #aiah-aiai 8demon/rat$ its almo/ specific action 9 respiratory affections02 t 8dur+ ?is epidemic x prov$ to be five times z efficaci\s z any o!r treatm5t 9 pneumonia 44402 & t 8x is n[ z firmly fix$ 9 ! m9d ( _m doctors = respiratory diseases z qu99e is = mal>ia & ! salicylates = rheumatism40 ,9 ! booklet x is fur!r /at$ t ! !rapeutic action ( ! prep>ation is prim>ily t ( a 8/imulat+ expectorant0 & second>ily z a 8s$ative expectorant02 t 8its antiseptic action 9 ! respiratory tract is prompt02 t x 8is an effectual c>diac tonic :]e ! tone ( ! he>t muscle is impair$ by fev]02 t 89 acute pulmon>y conditions x effectively improves ! respiratory action & allays c]ebral irritation due to fev] & tox9s02 t x acts 8z a vital /imulant & n]ve s$ative02 t 8x /imulates ! excretion ( acid by ! sk9 & 9 fev] x has a /rongly diaphoretic & antipyretic action )\t depress+ ! circulation or ! c5tral n]v\s sy/em02 t x is 8mildly diuretic0 & 8slightly augm5ts ! bili>y fl[0 & t 8x increases ! ga/ric & inte/9al secretions & allays inte/9al f]m5tation40 ,no evid5ce has be5 pres5t$ to ! ,c\ncil :i* %[s t ,syrup ,lept9ol has ! actions ascrib$ to x4 ,! reports ( cl9ical trial are little m ?an *ance obs]vations & lack all control4 ,?is applies also to ! foll[+1 /at$ to be a quotation f ! report ( ! ,tonopah ,m9es ,hospital ,association3 8,9 ! spr+ ( #aiai a recurr5ce ( ! ,influ5za epidemic ( ! previ\s w9t] 0 exp]i5c$4 ,dur+ ! fir/ p]iod ( ?is second epidemic1 prior to ,april #ae?1 !re 7 treat$ "o hundr$ sixte5 cases ( ,influ5za1 f\rte5 ( :i* develop$ ,influ5zal ,pneumonia1 ) six dea?s4 ,! ,pneumonia 0 ( ! v virul5t type :i* prevails 9 ?is high altitude4444 ,aft] ,april #ae?1 :5 ! cl9ical use ( ,lept9ol 0 inaugurat$1 ?ree hundr$ & sixty-eight cases ( ,influ5za 7 treat$ & n a s+le case develop$ ,pneumonia4 ,tw5ty-two cases ( ,influ5zal ,pneumonia 7 receiv$ & treat$ ) ,,lept9ol1 ) a consequ5t "o hundr$ p] c5t4 recov]y4444 8,9 ! cases :]e ,,lept9ol 0 us$ ! treatm5t 0 ! same z _h be5 previ\sly foll[$1 z to diet1 fre% air1 etc41 b ! m$ication 0 conf9$ to ,,lept9ol4 ,syrup ,,lept9ol 0 />t$ imm$iately 9 "o-dram doses at "o-h\r int]vals1 9 cases ) high temp]atures1 & ?is 0 cont9u$ until temp]ature & pulse subsid$4 ,x 0 !n us$ 9 "o-dram doses at ?ree-h\r int]vals z recov]y progress$4 ,on admission to ! hospital1 calomel 9 #a_/d gra9 doses1 0 giv5 at fifte5 m9ute int]vals = eight doses4 ,! la/ calomel 0 foll[$ 9 six h\rs by #a_/b ounce ,magnesium ,sulphate 9 saturat$ solution4 ,! second day #a_/aj gra9 ( calomel 0 giv5 at "o-h\r int]vals = t5 doses44440 ,m$ical j\rnals are replete ) reports ( rem>kable results obta9$ ) ! mo/ v>i$ =ms ( treatm5t in/itut$ at ! "t t ! 8influ5za epidemic0 _h be5 rea*$4 ,9 ^! cases x is m ?an probable t ! less5$ virul5ce ( ! causative factor ( ! disease1 ! gradually e/abli%$ resi/ance ( ^? /rick5 ) x 9 ! latt] p]iod & ! improv$ managem5t result+ f exp]i5ce des]ve ! cr$it = ! successful outcome ( ! treatm5t1 r ?an ! p>ticul> =m ( m$ication employ$4 ,! report ( ! ,tonopah ,m9es ,hospital ,association directly implies t ,syrup ,lept9ol prev5ts ! developm5t ( pneumonia 9 practically all cases ( influ5za 9 :i* x w\ld develop & t x entirely aboli%es ! mortality ( t disease4 ,h[ev]1 x is well kn[n t innum]able rem$ies h be5 recomm5d$ z specifics 9 ! treatm5t ( pneumonia on ! basis ( ! treatm5t ( a limit$ numb] ( cases :i* recov]$1 & t ev5tually ^! ass]t$ specifics h be5 disc>d$ z ( little value4 ,9 ! pres5t in/ance1 ! recov]y ( tw5ty-two cases 9 succession af=d prima facie evid5ce t ^? cases 7 n ! virul5t type ( pneumonia 9 :i* ! dea? rate is v high "u any me?ods ( treatm5t4 ,:ile no ef=t appe>s to h be5 made to det]m9e ! nature ( ! infect+ organism1 ! records %[ fairly conclusively t !y belong$ to ^? caus+ ! mild] type ( pneumonia4 ,! ,c\ncil f9ds ,syrup ,lept9ol 7=m]ly ,syrup ,balsamea7 inadmissible to ,new & ,non(ficial ,rem$ies because3 7#a7 ! in=mation 9 reg>d to composition does n /ate ! am\nt ( pot5t +r$i5t1 nor p]mit ! det]m9ation ( its id5tity & uni=mity2 7#b7 ! recomm5dation = its use 9 su* infecti\s diseases z pneumonia & epidemic influ5za is unw>rant$ & its claim$ !rapeutic efficacy 9 o!r diseases is )\t satisfactory support+ evid5ce2 & 7#c7 ! recomm5dations = its use :i* appe> on ! label & ! circul> wrapp$ ) ! trade package con/itute an indirect adv]tisem5t to ! public4 ,! ,c\ncil accepts ! explanation ( ! manufactur] t he has be5 unable to obta9 a satisfactory classification ( ! plant f :i* ,syrup ,lept9ol is made4 ,x w\ld be undesirable to exclude f !rapeutic use a valuable drug simply because its botanical "* has n be5 det]m9$ or because an exhau/ive *emical exam9ation _h s f> n be5 made4 ,h[ev]1 9 ! abs5ce ( su* in=mation ! manufactur] %\ld give full in=mation ) reg>d to ! prep>ation or /&>dization ( 8 rem$y & ! !rapeutic claims made = x %\ld be accompani$ by indisputable1 ?or\ghly controll$ cl9ical evid5ce4 ,9 ! case ( ,syrup ,lept9ol1 !re is no satisfactory evid5ce available %[+ t ! prep>ation has any value 9 ! treatm5t ( epidemic influ5za1 pneumonia1 :oop+ c\gh1 etc4 ,:ile x is probable t a balsamic syrup1 su* z ,syrup ,lept9ol1 has palliative prop]ties 9 c\ghs1 su* action does n at all ju/ify ! claim t x is useful 9 ! contagi\s diseases = :i* x is propos$4 ,! ,c\ncil _c recognize a syrup pres5t+ an unkn[n plant 9 unc]ta9 proportions :i* is recomm5d$ 9 a v>iety ( dang]\s contagi\s diseases 9 :i* x ultimately may be h>mful1 ev5 ?\gh 9 e>ly /ages ( ^! diseases x may s]ve to allay "s ( ! mild] symptoms4 ,conc]n+ ! composition ( ! plant f :i* ,syrup ,lept9ol is prep>$1 ! ,balsamea ,company /ates t x conta9s 8,alkaloids1 acids1 glucosides1 volatile & fix$ oils1 gums & res9s40 ,?is in=mation is valueless1 s9ce no in=mation is giv5 conc]n+ ! "*1 am\nts or ph>macologic action ( ! +r$i5ts4 ,fur!r1 x is unreliable z f> z ! pres5ce ( alkaloids is conc]n$ s9ce ! ,a4 ,m4 ,a4 ,*emical ,laboratory has be5 unable to f9d any alkaloids 9 ! specim5 ( ! crude drug furni%$ by ! manufactur]s4 ,9 accordance ) its regul> proc$ure1 ! ,c\ncil submitt$ ! prec$+ /atem5t to ! manufactur]4 ,9 reply ! ,balsamea ,company /at$ t x is m ?an ev] ( ! belief t ,syrup ,lept9ol is des]v+ ( recognition by ! ,c\ncil1 bas+ ?is op9ion on fur!r cl9ical exp]i5ce ) x 9 ! treatm5t ( influ5za4 ,! manufactur] /at$ t ! use ( ! words 8,lept9ol0 & 8,syrup ,lept9ol0 int]*angeably 0 due to an ov]sight & promis$ to limit ! use ( ! ^w 8,lept9ol0 to an alcoholic extract ( ! plant4 ,conc]n+ ! me?od ( prep>ation ( ?is alcoholic extract & ! am\nt us$ 9 ! prep>ation ( ,syrup ,lept9ol ! ,balsamea ,company repli$ z foll[s3 8,! alcoholic extract ( ! ,leptota5ia1 :i* we h t]m$ #8,lept9ol' is a prep>ation ( def9ite & uni=m /r5g?1 z det]m9$ by two me?ods3 7a7 ! gravity te/ us+ ! ,u4 ,s4 ,hydromet] ,scale = spirits1 by :i* ,lept9ol regi/]s #eb degrees at #fj degrees ,f41 & 7b7 by g5tle evaporation ( ! alcohol cont5t & ! measur+ ( ! active con/itu5ts1 :i* measures tw5ty-five p] c5t4 by weight4 8,! alcoholic extract #8,lept9ol' is glyc]9at$ 9 a ma*9e1 us+ "o "p ( ! alcoholic conc5tration to f\r p>ts ( glyc]94 ,?is is !n add$ to elev5 p>ts ( a heavy syrup1 conta9+ #g-a_/b p\nds ( sug> to ! gallon ( syrup1 & ?or\ghly mix$ 9 an agitat+ ma*9e4 ,lept9ol is ! sole active +r$i5t ( ,syrup ,lept9ol4 ,syrup ,lept9ol is a prep>ation ( uni=m /r5g?4 ,x is f> m uni=m 9 /r5g? ?an mo/ ( ! syrups ( ! ,u4 ,s4 ,p4 made f fluid extracts :i* are made f crude drugs :i* are n uni=m 9 /r5g?40 ,?is claim _c be all[$ z meet+ ! conflict ) ,rule #a4 ,x is well kn[n t plants v>y 9 _! composition at diff]5t times ( ! ye>2 "u diff]5t conditions ( cultivation & gr[?2 & "u o!r conditions2 h5ce ! claim t alcoholic extracts ( equal specific gravity insure uni=mity ( composition 9 active pr9ciples mu/ be consid]$ entirely illogical1 especially s9ce ! exact nature ( ! active pr9ciples1 if any be pres5t1 is unkn[n4 ,if ^! are kn[n _! nature %\ld be /at$ & te/s = _! id5tity be giv54 ,if !y are unkn[n x is manife/ly mislead+ to /ate t ! prep>ation is ( uni=m /r5g?4 ,x is evid5t t ! ,c\ncil _c approve ( ! use ( a prep>ation ( unkn[n composition )\t satisfactory evid5ce ( its value1 especially :5 x is recomm5d$ 9 a v>iety ( s]i\s infecti\s diseases su* z influ5za & pneumonia4 ,! m]e fact t a small numb] ( pati5ts :o h receiv$ ! drug recov] is no evid5ce ( its curative value1 & until c>efully controll$ cl9ical te/s ( ! prep>ation are made1 x is n entitl$ to ! consid]ation ( physicians4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,june #e1 #aibj47 ,,=mitol ,,tablets1 ,,ii ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has au?oriz$ publication ( ! foll[+ supplem5t>y report on ,=mitol ,tablets4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,9 ! ,c\ncil report 7,! ,j\rnal ,a4 ,m4 ,a41 ,oct4 #d1 #aiai1 p4 #ajgg7 on ! ineffectiv5ess ( loz5ges claim$ ei!r to conta9 =maldehyd or to lib]ate =maldehyd 9 ! m\?1 ! composition ( ,=mitol ,tablets ( ! ,e4 ,l4 ,pat* ,co4 0 briefly discuss$ 9 ! foll[+ t]ms3 8,! ,a4 ,m4 ,a4 ,*emical ,laboratory report$ t ,=mitol ,tablets conta9$ =maldehyd 7or p>a=maldehyd71 an ammonium comp\nd1 & "s hexame?yl5am94 ,x is probable t ! =maldehyd 7or p>a=maldehyd7 0 produc$ by ! decomposition ( hexame?yl5am9 orig9ally pres5t 9 ! tablets b decompos$ by long contact ) ! acid40 ,at ! "t ?is report 0 publi%$1 ! label & ! adv]tis+ matt] conta9$ b vague & indef9ite /atem5ts ) reg>d to ! composition ( ,=mitol ,tablets4 ,9 ! ,octob]1 #aiai1 issue ( ,pat*work1 ! h\se organ ( ! ,e4 ,l4 ,pat* ,co41 x 0 d5i$ t ^! tablets conta9 hexame?yl5am9 s9ce none _h ev] be5 us$ 9 _! manufacture4 ,x 0 also claim$ t ! company _h a 8pr9t$ %eet giv+ ! =mula ( ^! tablets40 ,! ,c\ncil advis$ ! ,e4 ,l4 ,pat* ,co4 t x desires to publi% only facts ab\t ! products :i* x exam9es & t if ! report on ,=mitol ,tablets 0 inaccurate 9 any way ! ,c\ncil w\ld want to correct any error x might h un9t5tionally made4 ,z ! ,=mitol adv]tis+ 9 ! files ( ! ,c\ncil conta9$ no in=mation z to ! composition ( ! tablets1 ! firm 0 also reque/$ to s5d ! pr9t$ %eet giv+ ! 8=mula40 ,:5 ?is pr9t$ 8=mula0 came x 0 f\nd to be a %eet us$ by ! ,e4 ,l4 ,pat* ,co4 = ! purpose ( giv+ its salesm5 in=mation reg>d+ ,=mitol tablets1 to be pass$ on to ! physician4 ,?is pr9t$ %eet convey$ ! in=mation t ,=mitol ,tablets conta9 ammonium *lorid1 b5zoic acid1 citric acid1 guaiac1 hyoscyamus1 m5?ol1 p>a=maldehyd & tannic acid1 b x gave no in=mation 9 reg>d to ! am\nt ( any ( ! +r$i5ts except t x decl>$ t ea* tablet repres5ts ! equival5t ( #aj m9ims ( a #a p] c5t4 =maldehyd solution4 ,because ( ! nonquantitative1 &1 !re=e mean+less pr9t$ 8=mula0 & because1 also1 ( its complexity1 x 0 ?\ght desirable to make a m complete analysis ( ,=mitol ,tablets4 ,exp]i5ce has %[n t frequ5tly ! real =mula ( a ?+ is q diff]5t f ! alleg$ =mula publi%$ by ! manufactur]4 ,! details ( ! laboratory's lat] analysis w appe> 9 ! ,annual ,reports ( ! ,*emical ,laboratory or may be _h on reque/4 ,! result ( ! laboratory's additional exp]im5tal "w1 especially :5 tak5 9 connection ) inve/igations made else:]e on ! int]action ( =maldehyd & ammonium *lorid ju/ifies ! conclusion t ,=mitol ,tablets d conta9 "s hexame?yl5am91 ev5 ?\gh ! am\nt may be v small4 ,z ! ,e4 ,l4 ,pat* ,co4 decl>e t no hexame?yl5am9 is put into ,=mitol ,tablets ! conclusion drawn 9 ! ,c\ncil's orig9al report to ! effect t ! =maldehyd probably 0 =m$ by ! decomposition ( hexame?yl5am9 0 evid5tly an error4 ,! hexame?yl5am9 pres5t is d\btless produc$ by ! action ( ! p>a=maldehyd on ! ammonium *lorid pres5t4 ,! analysis also %[$ t m ?an #gh p] c5t4 ( ! weight ( ,=mitol ,tablets 0 made up ( sug>s & ab\t #af4e p] c5t4 0 />* & o!r mat]ial1 "s ( :i* 0 talcum or simil> mat]ial4 ,?is means t ab\t #id p] c5t4 ( ! total weight ( ! tablets is sug> & />*1 nei!r ( :i* is m5tion$ 9 ! pr9t$ 8=mula40 ,! significance ( ?is is app>5t :5 x is consid]$ t !re are eight +r$i5ts li/$ 9 ! 8=mula0 = :i* !rapeutic effects are claim$4 ,s9ce a tablet weighs ab\t #ac4e gra9s1 ! comb9$ weight ( all ! claim$ active +r$i5ts is less ?an #a gra9 p] tablet6 ,! am\nt ( ammonium *lorid f\nd1 z indicat$ by ! total nitrog51 0 n m ?an #a4j p] c5t4 or ab\t #a_/h gra9 p] tablet4 ,! am\nt ( b5zoic acid f\nd 0 #j4cd p] c5t4 or #a_/be gra9 p] tablet4 ,yet ^! two drugs are said to ex]t _! peculi> expectorant action4 7,! ,u4 ,s4 ,p4 loz5ge ( ammonium *lorid conta9s #a-a_/b gra9s ammonium *lorid or twelve times ! am\nt ( ?is drug 9 a ,=mitol ,tablet47 ,! tannic acid conta9$ 9 ! tablets c\ld n be det]m9$ ) accuracy b x 0 mu* less ?an #a p] c5t4 7or #a_/h gra9 p] tablet7 yet x is said to add valuable a/r+5t qualities to ,=mitol ,tablets6 7,! ,u4 ,s4 ,p4 loz5ge ( tannic acid conta9s #a gra9 ( tannic acid47 ,! quantity ( guaiac 7z res97 is b a fraction ( #a p] c5t4 ,yet x is said to imp>t to ,=mitol ,tablets 8/imulant resolv5t0 prop]ties & x is intimat$ t !re is suffici5t to be ( value 9 8cases ( abscess ( ! ?roat & inflammation ( ! tissues40 ,! total acidity indicates ! pres5ce ( ab\t #b p] c5t4 ( citric acid or #a_/d gra9 p] tablet4 ,yet ?is am\nt is said to be 8antiseptic0 & 8aids 9 ! g5]al results40 ,:ile ! pres5ce ( ! drug hyoscyamus 7h5bane7 0 n positively id5tifi$ by microscopic exam9ation1 alkaloids 7 pres5t4 ,! manufactur]s claim t ! tablets conta9 m5?ol yet only a sugge/ion ( m5?ol c\ld be obta9$ f ! odor4 ,h[ev]1 ! odor ( me?yl salicylate--a con/itu5t n decl>$ 9 ! 8=mula0--pr$om9at$ ?r\gh\t ! op]ations ( analysis4 ,=mitol ,tablets furni% a good illu/ration ( "s well e/abli%$ b (t5 ignor$ tru?s3 #a4 8,=mulas0 t are nonquantitative are valueless or worse ?an valueless4 #b4 ,! fact t a manufactur] puts c]ta9 drugs 9 a mixture1 is no pro( t ^! drugs are !re :5 ! mixture rea*es ! pati5t4 ,! physician mu/ be assur$ t !y are !re :5 he prescribes !m4 #c4 ,complex mixtures %\ld be avoid$4 ,x is absurd to expect1 z is claim$ 9 ! case ( ,=mitol ,tablets1 anodyne1 antiseptic1 a/r+5t1 expectorant1 & resolv5t action all at ! same "t4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,june #ai1 #aibj47 ,,sukro-,,s]um ,,& ,,aphlegmatol ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,two ye>s ago1 ,am]ican newspap]s conta9$ acc\nts ( an alleg$ cure = pulmon>y tub]culosis 8discov]$0 by ,pr(4 ,dom5ico ,lo ,monaco ( ,rome1 ,italy4 ,at t "t no ref]5ce to ! 8cure0 c\ld be f\nd 9 m$ical j\rnals :i* _h come f ,italy & o!r ,european c\ntries 7,! ,j\rnal ,a4 ,m4 ,a41 ,july #ac1 #aiah1 p4 #adb74 ,lat]1 reports 7 publi%$ ( exp]im5ts c>ri$ out 9 ,italy1 accord+ to :i* ! intramuscul> injection ( solutions ( sug> 7sac*>ose--cane sug>7 dim9i%$ pulmon>y secretion & 0 ( consid]able value 9 ! treatm5t ( tub]culosis 7,! ,j\rnal ,a4 ,m4 ,a41 ,sept4 #bh1 #aiah1 p4 #ajhc74 ,on ! :ole ! reports ( ! trial ( :at has be5 call$ ! ,italian ,sug> ,cure = ,consumption h be5 unfavorable4 ,at a meet+ 9 ,p>is 9 ,octob]1 #aiah1 ,drs4 ,l\is ,rnon & ,mignot report$ t !y _h f\nd t ! disease 9 gu9ea-pigs 0 n modifi$ by ! treatm5t & ) humans ! results 7 also negative 7,p>is ,lett]1 ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #bc1 #aiah1 p4 #agfj74 ,9 view ( ! exploitation ( ?is treatm5t 9 ! ,unit$ ,/ates by ! ,anglo-,fr5* ,drug ,co41 :i* (f]s 8,sukro-,s]um10 & by ,g4 ,giambalvo ,co41 :i* sells 8,aphlegmatol10 & because ( inquiries receiv$1 ! ,c\ncil has au?oriz$ publication ( ! /atem5t :i* foll[s4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,a circul> issu$ by ! ,anglo-,fr5* ,drug ,co41 describes 8,sukro-,s]um0 z a 8,/]iliz$ ,solution ( lacto-gluco-sac*>ose40 ,by read+ ! circul> to ! end1 h[ev]1 "o le>ns t 8,sukro-,s]um0 is n a 8s]um0 9 ! ord9>y s5se b app>5tly x is a solution ( ord9>y sug> 7sucrose74 8,sukro-,s]um is a /]iliz$1 specially prep>$ solution ( ,sac*>ose40 ,sukro-,s]um has be5 adv]tis$ 7,n4 ,y4 ,m$4 ,j\r41 ,sept4 #f1 #aiai7 z an 8,,intramuscul> ,,injection ,,= ,,tub]culosis0 8444 ready = use 9 cases ( ,pulmon>y & g5]al ,tub]culosis0 ) ! ass]tion t 8,x is q c]ta9 t 9 ! ne> future ,sukro-,s]um w be l>gely us$ & its value fully recogniz$40 ,! circul> receiv$ f ! ,anglo-,fr5* ,drug ,co4 conta9s quotations f an article by ,pr(essor ,lo ,monaco 9 ! ,briti% ,m$ical ,j\rnal 7,aug4 #bd1 #aiah7 sett+ =? ! m]its ( intramuscul> injections ( sucrose 9 tub]culosis4 ,x is recomm5d$ t 8,noca9e-,surrn9e0 7:i* ! ,anglo-,fr5* ,drug ,co4 supplies7 be us$ = ! control ( pa9 :5 ,sukro-,s]um is inject$4 ,! circul> enclos$ ) a package ( 8,aphlegmatol10 pur*as$ f ,g4 ,giambalvo ,co41 conta9$ ! foll[+ ) ref]5ce to ! composition ( ?is prep>ation3 8,a solution ( ,hydrats ( ,c>bon ,aft] ! =mula ( ,pr(4 ,d4 ,lo ,monaco1 ,director ( ! ,in/itut ( ,physiological ,*emi/ry ( ! ,univ]sity ( ,rome4 ,cont5ts3 ,sucrose 7,c,h,o7 ,glucose & ,galactose 7,c,h,o740 ,! package conta9$ ampules ( ?91 fragile1 br[n color$ glass1 conta9+ approximately #b-a_/b c4c4 ( light1 cle>1 amb] color$1 ?ick1 /icky fluid1 hav+ a di/9ct c>amel odor4 ,reaction p,h #e4j4 ,a r$uc+ sub/ance 7probably glucose7 am\nt+ to #g4d p] c5t4 0 f\nd by us+ ,b5$ict's me?od = e/imat+ glucose quantitatively2 aft] hydrolysis ) hydro*loric acid1 #ee4e p] c5t4 glucose 0 f\nd4 ,!re 0 no reaction = album94 ,no attempt 0 made to id5tify ! sug>s1 z x seem$ probable t 9 ! prep>ation c>amel _h be5 produc$4 ,! circul> :i* accompani$ ! package ( ,aphlegmatol conta9$ ! foll[+ in=mation 7spell+ & composition z 9 orig9al7 ab\t its use & effects3 ,to be emploi$ :]e a l>ge bron*ial secretion is pres5t 9 ! respiratory bran*es disease4 ,! secretion w dim9i% &1 9 non complicat$ cases1 x w completely disappe>4 ,fev]1 c\gh1 hemottisis1 night p]spiration1 vomit+ & difficulty ( brea?+ are1 9 ! meantime1 dim9ui%$4 ,aphlegmatol acts also z a ricon/itu5t1 be+ itself a nurri%+ composition1 improves ! dige/ive function ( ! body & increases ! art]ial pressure4 #e c4c4 7#b ,phials7 ( ,aphlegmatol p] day mu/ be inject$ intramuscul>ly 9 ! ,gluteus4 ,if ! pati5t wi%es two injections may be made1 "o at ! "r imm$iately foll[$ by a second "o at ! left4 ,! cure mu/ n be int]rupt$ untill sometime aft] expectoration has disappe>$1 :i* result may be obta9$ only aft] fifty or sixty days1 9 ! meantime ! pati5t mu/ be controll$ by 8 home physician1 especialy :5 !rmal elevation ( ! body takes place4 ,improvem5t w be manife/$ on or ab\t ! t5? day ( ! fir/ injection4 ,9 ! adv]tis+ circul>1 :i* is app>5tly int5d$ = g5]al di/ribution1 mu* ! same in=mation is giv5 z 9 ! %eet enclos$ ) ! ampules1 except t 9 ! directions we f9d3 8,if ! injections are pa9ful--especially 9 cases :]e pati5ts are v emaciat$--physicians are advis$ to inject toge!r ) ,aphlegmatol1 z an ane/hetic1 a vial ) #a c4c4 solution ( ,/ova9 at #c40 ,! adv]tis+ = ,aphlegmatol conta9s _m misspell$ words & appe>s to be ! "w ( ^? ignorant ( ! ,engli% language4 ,tub]culosis is a widespread disease & a majority ( ! un9=m$ are only too will+ & ready to try su* a 8cure40 ,! prep>ations appe> to be no?+ m ?an conc5trat$ solutions ( sug>4 ,x is probable t a small am\nt ( ! cane sug> might be inv]t$ to glucose & fructose1 b exp]im5ts h %[n t cane sug> subcutane\sly adm9i/]$ 9 ! small am\nts us$ 9 ?is in/ance is l>gely excret$ 9 ! ur9e un*ang$4 ,less is kn[n ab\t galactose1 b ! evid5ce available w\ld indicate t galactose is l>gely excret$ 9 ! ur9e un*ang$ :5 giv5 subcutane\sly4 ,glucose w\ld be absorb$ z su*1 & 9 ! am\nts "u consid]ation1 us$ by ! sy/em mu* ! same z :5 giv5 by m\?4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,aug4 #ba1 #aibj47 ,,supsalvs ,,n ,,admitt$ ,,to ,n4 ,n4 ,r4 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has au?oriz$ publication ( ! foll[+ report decl>+ ,supsalvs 7,anglo-,fr5* ,drug ,company7 inadmissible to ,new & ,non(ficial ,rem$ies4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,supsalvs are adv]tis$ by ! ,anglo-,fr5* ,drug ,company z 8/able suppositories ( #8#fjf' 7( ,fr5* manufacture70 ) ! claim t by ! rectal adm9i/ration ( ^! suppositories ! effects ( arsph5am9e may be obta9$4 ,! ass]t$ efficacy ( ,supsalvs m$ication is bas$ 9 "p on ! claim t = ^! suppositories an excipi5t 0 f\nd :i* mixes ) ! cocoa butt] base 8to =m an assimilable emulsion40 8,! active pr9ciple & ! vehicle be+ b\nd to "o ano!r1 ! muc\s membrane is able to absorb bo? simultane\sly & progressively 9 ! =m ( an organic emulsion40 ,z no in=mation 0 furni%$ ! ,c\ncil by ! ,anglo-,fr5* ,drug ,company on ! orig9 or quality ( ! arsph5am9e us$ 9 ! prep>ation ( ,supsalvs or ! "* ( ! vehicle :i* 0 8b\nd0 to ! arsph5am9e 9 su* a way z to p]mit ! absorption ( ?is comb9ation 9 ! =m ( an 8organic emulsion10 ! firm 0 reque/$ to furni%3 7#a7 ,evid5ce t ! arsph5am9e us$ 9 ,supsalvs complies ) ! ,n4 ,n4 ,r4 /&>ds & t det]ioration ( x does n occur 9 ! prep>ation ( ! suppositories or on keep+4 7#b7 ,! id5tity ( ! +r$i5ts compos+ ! suppository4 ,! ,anglo-,fr5* ,drug ,company did n supply ! reque/$ evid5ce & consequ5tly ! ,c\ncil judg$ ! prep>ation on ! basis ( ! in=mation receiv$ f ! company1 & t conta9$ 9 ! available adv]tis+ & circul>s4 ,x f\nd ,supsalvs inadmissible to ,new & ,non(ficial ,rem$ies1 fir/ because ! quality ( ! m$icam5t conta9$ 9 ! suppositories has n be5 e/abli%$1 & second because ! claim$ efficacy ( ?is prep>ation z a means ( secur+ ! effects ( arsph5am9e lacks sub/antiat+ pro(4 ,dur+ ! pa/ few ye>s "s ,fr5* physicians h report$ favorably on ! intr>ectal adm9i/ration ( arsph5am9e4 ,boyd & ,joseph at ,panama publi%$ 7,! ,j\rnal1 ,aug4 #ag1 #aiah1 p4 #eba7 an en?usia/ic report on intr>ectal injection ( arsph5am9e b did n ref] to its use 9 ! =m ( suppositories4 ,9 a compreh5sive report1 on ! 8,treatm5t ( ,syphilis0 7,qu>t]ly ,j\rnal ( ,m$ic9e1 ,july1 #aiag7 ,l4 ,w4 ,h>rison /at$ t arsph5am9e 7,salv>san7 9 ! %ape ( an enema is def9itely less effective ?an intrav5\sly & t 8,neiss] & ! va/ majority ( work]s c see no value 9 ! rectal me?od40 ,s*amb]g & ,hirs*l] 7,a ,safe & ,effici5t ,int5sive ,me?od ( ,treat+ ,syphilis1 ,!rapeutic ,gazette1 ,novemb]1 #aiai1 p4 #gfa7 h giv5 a r ?or\gh trial ( ?is me?od2 ! results 7 mo/ disappo9t+3 8,a c]ta9 or r unc]ta9 am\nt ( arsph5am9e is absorb$ into ! blood1 b ! quantity is obvi\sly too small to be at all comp>able 9 its effect ) ! intrav5\s adm9i/ration4 ,our conclusions are t ! rectal adm9i/ration ( arsph5am9e or neo>sph5am9e is an extremely feeble me?od ( adm9i/]+ ^! drugs40 ,! report ( ! ,special ,committee on ! ,manufacture1 ,biological ,hi/ory & ,cl9ical ,adm9i/ration ( ,salv>san & ,o!r ,sub/ances ( ! ,briti% ,national ,heal? ,insurance ,m$ical ,rese>* ,committee conta9s ! foll[+3 8,! rectal me?od ( adm9i/ration1 ei!r 9 ! =m ( solution or z suppositories1 has be5 advocat$ by a few obs]v]s ma9ly = cases 9 :i* !re is difficulty 9 ! adoption ( ! intrav5\s me?od4 ,! exp]im5ts made by ,mills at ,ro*e/] ,r[ %[ t ?ree enemata ( #8#fjf' 7#j4f ,gm4 9 ea*7 on successive days fail$ to produce any effect on ! spironemes 9 ! lesions4 ,! g5]al op9ion ( exp]i5c$ work]s is t ! rectal me?od is ineffective1 & 9 ?is view ! ,committee concur40--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,oct4 #cj1 #aibj47 ,,hypod]mic ,,solution ,,no4 #ac1 ,,iron1 ,,ars5ic ,,& ,,phosphorus ,,comp\nd ,,n ,,accept$ ,,= ,n4 ,n4 ,r4 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has au?oriz$ publication ( ! foll[+ report4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,hypod]mic ,solution ,no4 #ac1 ,iron1 ,ars5ic & ,phosphorus ,comp\nd 7,burdick-,abel ,laboratory7 is said to conta9 9 ea* c4c43 ,f]r\s citrate #j4jf ,gm4 ,sodium cacodylate #j4jf ,gm4 ,sodium glyc]ophosphate #j4a ,gm4 ,*loretone #j4jje ,gm4 ,! prep>ation is adv]tis$ z 8! old reliable hemat9ic0 :i* is 8indicat$ 9 all =ms ( anemia1 :]e bo? r$ & :ite cells are l[40 ,x is = hypod]mic or intramuscul> adm9i/ration4 ,! product is inadmissible to ,new & ,non(ficial ,rem$ies because3 #a4 ,x does n conta9 f]r\s citrate z claim$4 ,in/ead ! iron is 9 ! f]ric condition1 app>5tly 9 ! =m ( ! un(ficial & un/&>diz$ 8iron citrate gre50 = :i* !re is no evid5ce ( sup]iority ov] ! (ficial iron & ammonium citrate4#acd #acd ,iron ,citrate ,gre51 ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #ab1 #aiag1 p4 #ace2 ,reports ,c\ncil ,ph>m4 & ,*em41 #aiaf1 p4 #db4 #b4 ,its "n gives no in=mation on ! =m 9 :i* ! iron1 ! ars5ic & ! phosphorus occur !re94 ,! t]m 8ars5ic0 does n indicate :e!r ! mild cacodylate or ! pot5t ars5\s oxid is be+ adm9i/]$ nor does ! t]m 8phosphorus0 tell ! physician t he is adm9i/]+ ! practically in]t sodium glyc]ophosphate4#ace--7;,f ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #ac1 #aibj47 #ace ,glyc]ophosphates1 ,! ,j\rnal ,a4 ,m4 ,a41 ,sept4 #cj1 #aiaf1 p4 #ajcc2 ,reports ,c\ncil ,ph>m4 & ,*em41 #aiaf1 p4 #cb4 ,sodium glyc]ophosphates4 ,reports ,c\ncil ,ph>m4 & ,*em41 #aiaf1 p4 #eb4 ,,p>a!s9 ,,n ,,admitt$ ,,to ,n4 ,n4 ,r4 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has au?oriz$ publication ( ! foll[+ report4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,! local ane/hetic e?yl p>am9ob5zoate 0 fir/ introduc$ z 8,ane/hes90 or 8,an/hes940 ,e?yl p>am9ob5zoate is n pat5t$ 9 ! ,unit$ ,/ates & x may be manufactur$1 !re=e1 by any firm :i* *ooses to d s4 ,9 ord] t a common "n by :i* to designate ! drug might be available1 ! ,c\ncil co9$ ! "n 8,b5zoca9e10 z be+ %ort & easily rememb]$1 b yet sugge/ive ( its composition & "* 78b5zo0 to indicate its d]ivation f b5zoic acid & 8ca9e0 to indicate its coca9e-l prop]ties74 ,z ! t]m 8ane/hes90 _h become a common "n = ! drug1 ! ,c\ncil recogniz$ ?is z a synonym = b5zoca9e4 ,"o ( ! accept$ br&s = b5zoca9e is 8,ane/hes910 manufactur$ by ! ,h4 ,a4 ,metz ,laboratories1 ,inc4 7see ,new & ,non(ficial ,rem$ies1 #aibj1 p4 #cc74 ,h[ev]1 on ,april #ai1 #aibj1 ! ,metz ,laboratories reque/$ t its product be recogniz$ "u ! designation ( 8,p>a!s940 ,z ! use ( "o sub/ance "u sev]al names causes confusion & ret>ds rational !rapeutics1 ! ,c\ncil's rules provide aga9/ ! recognition ( propriet>y names = nonpropriet>y1 e/abli%$ drugs4 ,9 view ( ?is & because ! legitimate int]e/s ( ! manufactur] may be safegu>d$ by app5d+ 8 "n or initials to ! common "n1 b5zoca9e or ane/hes91 ! ,c\ncil vot$ n to recognize ! designation 8,p>a!s940--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #ac1 #aibj47 ,,*lorlyptus ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! cond5s$ report on ,*lorlyptus :i* foll[s & also a complete detail$ report 0 s5t to ! proprietor1 ,jan4 #i1 #aibj4 ,9 reply he reque/$ t publication be po/pon$ p5d+ ! submission ( fur!r cl9ical evid5ce4 ,z aft] n9e mon?s ?is evid5ce _h n be5 receiv$ ! ,c\ncil has au?oriz$ publication ( its report4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,*lorlyptus is manufactur$ by ,*as4 ,a4 ,weeks1 trad+ z ! ,weeks ,*emical ,company1 ,philadelphia4 ,x is prep>$ by *lor9at+ eucalyptus oil until x has b\nd #cj p] c5t4 ( *lor91 ! *lor9 be+ 9 relatively /able comb9ation4 ,x is claim$ t ,*lorlyptus is a new 8*lor9at$ antiseptic10 highly effici5t z a w\nd antiseptic & at ! same "t nonirritant & nontoxic4 ,*lorlyptus is (f]$ = use 9 ! treatm5t ( local infections ( all types1 z well z ( burns1 & also z an antiseptic 9 ! alim5t>y & g5ito-ur9>y tracts4 ,! claims 7 bas$ l>gely on reports ( inve/igations made by ,philip ,b4 ,hawk & 8 collaborators4 ,^! reports ! ref]ee ( ! committee 9 *>ge ( ,*lorlyptus consid]$ incomplete & unconv9c+4 ,be+ advis$ ( ?is ,mr4 ,weeks caus$ fur!r inve/igations to be made4 ,"s ( ! in=mation 0 *eck$ & ext5d$ by ! ,a4 ,m4 ,a4 ,*emical ,laboratory & by ! ref]ee4 ,! laboratory side ( ! inve/igation may n[ be consid]$ z complete4 ,! results %[ t ,*lorlyptus is a feeble antiseptic ( ! aromatic oil type1 consid]ably weak] ?an eucalyptus oil1 bo? z to !rapeutic & toxic qualities4 ,! *lor9 conta9$ 9 x is b\nd too firmly to h any action2 9 fact1 ! *lor9ation appe>s to h accompli%$ no?+ m ?an a consid]able de/ruction or weak5+ ( ! eucalyptus oil4 ,z f> z ! ref]ee c judge1 ?is object c\ld h be5 accompli%$ j z effectively by dilut+ ord9>y eucalyptus oil ) "s indiff]5t solv5t4 ,! manufactur] ( ,*lorlyptus cont5ds t if ! exp]im5tal f9d+s are aga9/ 8 product1 x %\ld be judg$ by ! cl9ical data4 ,! cl9ical evid5ce1 h[ev]1 is n decisive4 ,x %[s t w\nds heal$ & infections 7 prev5t$ or successfully combat$ 9 cases 9 :i* ,*lorlyptus 0 us$ 9 comb9ation ) good surg]y1 b x does n %[ h[ mu* ( ! result 0 due to ! surg]y & h[ mu*1 if any1 to ! use ( ,*lorlyptus4 ,ev5 if x 7 grant$ z probable t ! ,*lorlyptus contribut$ to ! favorable outcome1 x w\ld /ill be a "q :e!r x equals o!r e/abli%$ antiseptics1 or :e!r x possesses any mat]ial advantages ov] dilut$ eucalyptus oil4 ,until ^! po9ts are e/abli%$ ! cl9ical reports _c (fset ! unfavorable results ( ! laboratory inve/igation4 ,! manufactur] has endeavor$ to obta9 m conv9c+ cl9ical reports1 b ! lack ( success 9 ?is direction dur+ ! pa/ n9e mon?s gives little enc\ragem5t t acceptable cl9ical evid5ce w be available )9 a reasonable "t4 ,believ+ t ! in=mation :i* has be5 obta9$ %\ld be made available to ! pr(ession1 ! ,c\ncil au?oriz$ publication ( ?is /atem5t & also ( ! detail$ report4 ,! ,c\ncil vot$ n to accept ,*lorlyptus = ,new & ,non(ficial ,rem$ies because ( ! unfavorable results ( ! laboratory inve/igation1 b ) ! agreem5t t ! product w\ld receive fur!r consid]ation %\ld m conv9c+ cl9ical data become available4 ,i4 ,,detail$ ,,reports ,summ>iz$ ,reports ,,*emical ,,nature ,,( ,,*lorlyptus ,*lorlyptus is prep>$ by *lor9at+ eucalyptus oil until x has b\nd #cj p] c5t4 ( *lor94 8,*lorlyptol0 is prep>$ 9 an analog\s mann] f eucalyptol4 ,!re has be5 "s confusion z to ! composition2 b ! pr9cipal con/itu5t is n[ /at$ to be 8a di*loride ( eucalyptus oil10 to :i* ! =mula ,c,h,o,cl has be5 assign$4 ,x diff]s f ! 8*lor9at$ eucalyptus oil10 z ord9>ily us$ = mak+ di*loram9-,t solutions1 & :i* conta9s only #b_/c p] c5t4 ( *lor94 ,,availability ,,( ,,*lor9 ,,9 ,,*lorlyptus ,! *lor9 cont5t ( *lorlyptus is almo/ entirely firmly b\nd1 & !re=e n 8available10 9 contra/ to ! gr\p ( s-call$ *lor9at$ antiseptics 7i4 e41 ! hypo*lorite & *loram9 type74 ,= in/ance1 x does n directly lib]ate iod9 f iodid4 ,x conta9s a v small quantity ( free hydro*loric acid1 or p]haps "s acid e/]s1 & lib]ates a little m on prolong$ contact ) wat]2 b ! total quantity lib]at$ "u reasonable conditions is v small4 ,accord+ to ,hawk's data1 !y correspond only to #a_/h p] c5t4 ,h,cl ev5 aft] /&+ ) wat] ov]night & to only #a_/e p] c5t4 ( ,h,cl aft] two weeks4 ,! ref]ee has %[n t ?is quantity ( acid has no !rapeutic significance4 ,! 8b\nd0 *lor9 ( *lorlyptus1 be+ *emically inactive1 w\ld h no m practical significance ?an ! b\nd *lor9 9 common salt4 ,! 8ozone0 said to be us$ dur+ ! prep>ation1 to expel ! ,h,cl1 has also practically disappe>$1 to judge by ! sl[ness ) :i* iod9 is lib]at$ f potassium iodid4 ,,acid ,,=mation ,"s con/itu5ts ( *lorlyptus hydrolyze sl[ly & to a slight degree ) ! lib]ation ( a trace ( free hydro*loric acid4 ,accord+ to ! data ( ,hawk's report1 ! free acidity1 9 t]m ( ,h,cl1 is #a_/ab p] c5t4 ,on /&+ ) wat] ov] night1 ?is increases to #a_/h p] c5t4 ,on ?is basis1 ,hawk propos$ a !ory t ! claim$ antiseptic effects ( *lorlyptus are due to ! cont9u\s lib]ation ( hydro*loric acid4 ,exp]im5ts by ! ref]ee %[ ?is to be unt5able4 ,! traces ( acid are neutraliz$ & absorb$ by ! tissues s rapidly t an acid reaction is n ma9ta9$4 ,^! exp]im5ts are describ$ 9 ! app5dix4 ,!y 7 submitt$ to ! manufactur]s1 :o 9 ! "n ( ,mr4 ,weeks 7,may #i1 #aiai7 conc$e ?is conclusion & /ate t 8!re is no d\bt t ! ref]ee's /atem5ts z to action 9 m\?1 contact ) liv+ tissue & improbability t ! acidity is effectively antiseptic is correct1 & ,i am will+ to accept ! ref]ee's /atem5t z conclusive 9 ?is respect40 ,,bact]ial ,,culture ,,exp]im5ts ,mr4 ,weeks submitt$ a /atem5t by ,hawk to ! effect t *lorlyptus has a ph5ol coeffici5t ( #b4f1 det]m9$ by ! /&>d ,hygi5ic ,laboratory proc$ure4 ,he also quotes ,rockefell] ,w> ,hospital t *lorlyptus kills ,/aphylococcus aureus 9 conc5tra ( #a dram3 #a gallon 7ab\t #a3a1jjj71 b n 9 m dilute solutions4 ,m rec5tly1 he pres5t$ a m compreh5sive report by ,rivas1 :i* is reproduc$ 9 ! app5dix4 ,! ess5tial results are tabulat$ h]e)4 ,?is tabulation %[s t *lorlyptus fails to kill ! organisms aft] an h\r's exposure ( ! foll[+ conc5trations3 ,typhoid 9 b\illon1 #aj p] c5t4 ( *lorlyptus4 ,/aphylococci 9 pus1 #e p] c5t4 ( *lorlyptus4 ,/aphylococci 9 s]um1 #a p] c5t4 ( *lorlyptus4 ,x seems to ! ref]ee t a sub/ance t is ineffective ) an h\r's exposure to ^! conc5trations is n at all likely to kill or *eck bact]ia "u cl9ical conditions4 ,9 o!r words1 x is n an antiseptic 9 ! ord9>y s5se4 ,! ref]ee is n impress$ by ! sup]ior p[] attribut$ by ,rivas to *lorlyptus 9 ! pres5ce ( pus4 ,ineffici5cy ( #aj p] c5t4 = "o-half h\r or ( #e p] c5t4 = two h\rs seems a failure r ?an a success4 ,! ref]ee also notes ! abs5ce ( any data z to ! relative effici5cy ( *lorlyptus aga9/ /aphylococci 9 pus & 9 b\illon4 ,! data on s]um indicate t *lorlyptus is mu* weak] ?an ph5ol & %[ t x is less effective 9 ! pres5ce ( pus ?an 9 o!r m$iums4 ,! ref]ee fails to grasp ! be>+ ( ! oil exp]im5ts on any cl9ical condition4 ,moreov]1 ! incon/ant results m5tion$ by ,rivas sugge/ ! possibility t ! incorporation ( ! bact]ia 9 oil may h prev5t$ _! effective di/ribution 9 ! culture m$ium4 ,if any significance is to be atta*$ to ^! exp]im5ts1 !y %\ld be *eck$ by controls1 )\t antiseptics4 ,,summ>y ,,( ,,rivas' ,,9 ,,vitro ,,exp]im5ts ,m9imal ,maximal ,g]micidal ,n ,g]micidal ,conc5trations ,conc5trations ,typhoid ,bacilli 9 ,b\illon3 ,*lorlyptus 7,exp4 #c7 #aj1 #b to #d h\rs #aj = #a h\r #e = #b h\rs ,eucalyptus oil 7,exp4 #a7 #e )9 #e m9utes ,no data ,ph5ol 7,exp4 #e7 #a )9 #aj m94 ,no data ,/reptococci & ,/aphylococci 9 ,olive ,oil3 ,*lorlyptus 7,exps4 #g & #h7 #a1 almo/ at once1 ,no data sometimes ,eucalyptus oil ,no data ,no data ,ph5ol 7,exps4 #i & #aj7 #a1 almo/ at once1 ,no data ,/aphylococci 9 ,pus3 ,*lorlyptus 7,exp4 #aa7 #aj = #a h\r #aj = #a_/b h\r #e = #b h\rs ,eucalyptus oil ,no data ,no data ,ph5ol ,no data ,no data ,/aphylococci 9 ,human ,blood ,s]um3 ,*lorlyptus 7,exp4 #ab7 #e 9 #a h\r #a 9 #a h\r ,eucalyptus oil ,no data ,no data ,ph5ol #e almo/ at once #a 9 #a h\r ---------------------------------------- ---------------------------- ,,infection ,,exp]im5ts ,,9 ,,vivo ,dr4 ,rivas reports two s]ies ( exp]im5ts1 9 ea* ( :i* ?ree gu9ea-pigs receiv$ /aphylococcus susp5sions 9 ! p]itoneum4 ,"o gu9ea-pig 9 ea* s]ies 0 left untreat$2 ! o!rs receiv$ injections ( *lorlyptus into ! p]itoneum at v>i\s int]vals4 ,! foll[+ results 7 obta9$3 ,*lorlyptus ,results ,exp4 #ai1 ,no4 #a ,none ,surviv$ ,exp4 #bj1 ,no4 #a ,none ,di$ ,exp4 #ai1 ,no4 #b ,at once ,di$ ,exp4 #ai1 ,no4 #c ,aft] #bd h\rs ,surviv$ ,exp4 #bj1 ,no4 #b ,aft] #ah h\rs ,di$ ,exp4 #bj1 ,no4 #c ,aft] #bd h\rs ,di$ ---------------------------------------- ------------ ,?is %[s mortalities (3 #a 9 #b1 i4 e41 #ej p] c5t41 )\t *lorlyptus4 #c 9 #d1 i4 e41 #ge p] c5t41 ) *lorlyptus4 ,x is d\btful :e!r s small a s]ies ( exp]im5ts on s v>iable a ph5om5on z is infection %\ld receive any s]i\s consid]ation4 ,s f> z !y g1 !y w\ld indicate t *lorlyptus is useless or worse4 ,,toxicity ,! ref]ee det]m9$ ! acute toxicity ( *lorlyptus by hypod]mic injection ( oily solutions into :ite rats4 ,comp>ative exp]im5ts 7 made ) ord9>y eucalyptus oil4 ,! details are giv5 9 ! app5dix4 ,! end-results may be summ>iz$ z foll[s3 ,surviv$ ,*lorlyptus ,eucalyptus ,oil #a4ef c4c4 #c4ge c4c4 #e4jj c4c4 #f4be c4c4 #a4be c4c4 #h4fe c4c4 #b4e c4c4 7#c days7 ,di$ 79 days7 #ab4e c4c4 7#a day7 #c4ge c4c4 7#c days7 #ab4e c4c4 7#a day7 #e4jj c4c4 7#c days7 #ah4ge c4c4 7#a day7 #f4be c4c4 7#a-a_/b days7 ,m4 ,f4 ,d4 #h4ge to #ab4e c4c4 p] kg4 #a4be to #b4e c4c4 p] kg4 ---------------------------------------- -------------------------- ,fatality4--,! doses are calculat$ = cubic c5timet]s ( ! undilut$ drugs p] kilogram ( rat4 ,dr4 ,rivas reports a s]ies ( toxicity exp]im5ts on gu9ea-pigs4 ,assum+ a uni=m weight ( #djj gm4 p] animal1 8 results 7details 9 app5dix7 may be summ>iz$ z3 ,m9imal ,maximal ,fatal ,dose ,surviv$ ,dose ,c4c4 p] ,kg4 ,c4c4 p] ,kg4 ,*lorlyptus1 p]itoneal 7,exp4 #ad7 #g4e c4c4 #e4j c4c4 ,*lorlyptus1 pleural 7,exp4 #ae7 #e4j c4c4 #b4e c4c4 ,eucalyptus oil1 p]itoneal 7,exp4 #af7 #b4e c4c4 ,no ,data ,eucalyptus oil1 pleural 7,exp4 #af7 #a4be c4c4 ,no ,data ,di*loram9-,t1 p]itoneal 7,exp4 #af7 #a4be c4c4 ,no ,data ---------------------------------------- -------------------------- ,! comp>ative toxicity 9 ! v>i\s s]ies is !re=e approximately z foll[s3 ,*lorlyptus 3 ,eucalyptus ,ref]ee1 rats1 hypod]mic #a_/e 3 #a ,rivas gu9ea-pig1 p]itoneal #a_/c 3 #a ,rivas gu9ea-pig1 pleural #a_/d 3 #a ---------------------------------------- ---------------- ,evid5tly1 ! toxicity ( *lorlyptus is ab\t "o-f\r? ( t ( eucalyptus oil4 ,! diff]5ce is consid]able1 b n fundam5tal4 ,moreov]1 ! symptoms ( *lorlyptus resemble ! *>act]i/ics ( eucalyptus oil4 ,accord+ to ! tabulation ( ,b>k] & ,r[ntree1#acf ! mean fatal dose ( eucalyptus oil = man1 9 ! tw5ty-n9e cl9ical cases report$ 9 ! lit]ature1 is ab\t #bj c4c4 ,if ! toxicity ratio ( ! two sub/ances 7 ! same z = ! rat exp]im5ts 7a r haz>d\s assumption71 ! fatal dose ( *lorlyptus = man w\ld be ab\t #hj c4c4 #acf ,b>k] & ,r[ntree 7,bull4 ,johns ,hopk9s ,hospital #bi3bae1 #bba ,oct4 #aiah7 obta9$ ! foll[+ results ) eucalyptus oil3 ,cat1 hypod]mic2 surviv$ #c c4c4 p] kg42 kill$ by #e4e c4c4 p] kg4 ,cat1 intrap]itoneal2 kill$ by #e c4c4 p] kg4 ,dog1 hypod]mic2 surviv$ #a4c c4c4 p] kg4 ,!y quote f ,br[n+ t ! foll[+ doses1 c4c4 p] kilogram1 are n fatal3 frogs1 #j4e2 rabbits1 #a to #e2 gu9ea-pigs1 #a4 ,,irritation ,rivas's ,exp]im5t #ad %[s t *lorlyptus gives v def9ite irritation1 app>5tly simil> to t produc$ 9 ,exp]im5t #af by eucalyptus oil 9 "o-f\r? ! dose4 ,incid5tally1 ! ref]ee may add f p]sonal exp]i5ce t ! 8*lorlyptus oil1 #e p] c5t4 ,cl0 is m>k$ly irritat+ 9 ! no/rils1 al?\gh m>k$ 8non-irritat+0 on ! label4 ,,ii4 ,,app5dix3 ,,special ,,reports ,a4 ,,comp>ison ,,( ,,*lorlyptus ,,) ,,*lor9at$ ,,eucalyptol ,f ! ,*emical ,laboratory ( ! ,am]ican ,m$ical ,association ,accord+ to ! label1 8,*lorlyptus0 is a 8,syn?atiz$ ,*lor9at$ ,oil ( ,eucalyptos1 ) ,acid ,reaction1 conta9+ approximately #cj p] c5t4 ,*lor9e & possesses excell5t ,g]micidal ,prop]ties1 :5 made "u our special process40 ,x is manufactur$ by ! ,weeks ,*emical ,company1 ,philadelphia1 ,pa4 ,?is product 0 submitt$ to ! ,c\ncil on ,ph>macy & ,*emi/ry by ! manufactur]s1 & 9 turn ! ,laboratory 0 ask$ to exam9e x ) ! idea ( comp>+ x ) ! nonpropriet>y br&s ( 8*lor9at$ eucalyptol0 7us$ z a solv5t = di*loram9e-,t2 see ,new & ,non(ficial ,rem$ies1 #aiai1 p4 #gj74 ,9 ! submission1 c]ta9 te/s 7 describ$1 mo/ ( :i* 7 foll[$4 ,among ! /atem5ts giv5 "u ! *emical prop]ties ( *lorlyptus are3 8,on di/illation1 *lorlyptus beg9s to boil at ab\t #ajj ,c4 ,! temp]ature rises z ! di/illation cont9ues1 accompani$ by ! decomposition ( ! *lorlyptus & ! evolution ( hydro*loric acid & *lor9e40 8,:5 br\ght into contact ) wat]1 *lorlyptus und]goes a process ( hydrolysis 4440 ,not)/&+ ! =ego+ ! /atem5t is made on ! label t *lorlyptus 8is a ,/able ,comp\nd1 n affect$ by heat1 light or wat]40 ,! foll[+ comp>isons ( *lorlyptus1 *lor9at$ eucalyptol-,abbott & *lor9at$ eucalyptol-,squibb 7 made3 ,*lorlyptus is a visc\s1 d>k br[n liquid1 ) an acrid odor & hav+ a specific gravity ( #a4bjih4 ,*lor9at$ eucalyptol-,abbott is a mobile1 light yell[ liquid1 ) a eucalyptus odor1 hav+ a specific gravity ( #j4icag4 ,*lor9at$ eucalyptol-,squibb is a mobile1 colorless liquid1 & its specific gravity is #j4icjc4 ,an alcoholic solution ( silv] nitrate add$ to an alcoholic solution ( *lorlyptus yields a heavy precipitate ( silv] *loride4 ,9 ! case ( ! ,abbott *lor9at$ eucalyptol a slight turbidity is caus$ by ?is te/2 ! ,squibb product %[s no reaction4 ,a #aj p] c5t4 solution ( potassium iodide is ov]laid ) an equal volume ( *lorlyptus4 ,iod9e is sl[ly lib]at$1 be+ noticeable 9 "o-half h\r4 ,) *lor9at$ eucalyptol-,abbott1 a trace ( free iod9e is disc]nible aft] f\r h\rs1 :ile ) *lor9at$ eucalyptol-,squibb !re is no free iod9e pres5t4 ,:5 ! respective products are %ak5 ) an alcoholic solution ( potassium iodide1 no iod9e is imm$iately lib]at$1 ?us %[+ ! abs5ce ( 8active *lor9e0 7diff]5ce f ! hypo*lorite d]ivatives74 ,:5 *lorlyptus is dissolv$ 9 conc5trat$ sulphuric acid1 "s black5+ occurs & ! odor ( hydrog5 *loride is v noticeable4 ,bo? ! ,abbott & ,squibb br&s ( *lor9at$ eucalyptol give a r$di% mixture1 ) no p]ceptible evolution ( hydrog5 *loride1 & /ill reta9 ! *>act]i/ic eucalyptol odor4 ,on heat+1 *lorlyptus decomposes & beg9s to boil at f #ajc to #aje ,c4 ,!n a high] fraction comes ov] at #agh ,c4 ,! di/illate has a %>p odor1 is acid1 & frees v little iod9e f potassium iodide4 ,*lor9at$ eucalyptol-,abbott does n seem to decompose4 ,"s gase\s sub/ance is giv5 (f at #hj ,c1 b ! liquid di/ills at #agc ,c4 ,! di/illate has no acid odor1 is neutral1 & lib]ates no iod9e f potassium iodide4 7,9 bo? cases ! di/illation 0 n c>ri$ to completion1 approximately only ab\t half ( ! volume be+ di/ill$ ov]47 ,,prelim9>y ,,te/s ,,on ,,*lorlyptus ,,& ,,*lor9at$ ,,eucalyptol ,*lor9at$ ,*lor9at$ ,*lorlyptus ,eucalyptol-,abbot ,eucalyptol-,squibb ,odor ,acrid ,l eucalyptus ,l eucalyptus ,d5sity & ,d>k br[n2 ,light yell[2 ,colorless2 color visc\s1 mobile2 light] mobile2 light] heavi] ?an wat] ?an wat] ?an wat] ,ag,n,o add$ ,heavy ppt4 ,slight turbidity ,cle> to alcoholic solution ,equal p>ts ,gives free ,gives free iod9 ,no free iod9 ) ,,ki iod9 sl[ly1 9 #d h\rs2 9 #d h\rs solution noticeable n mu* 9 #a_/b h\r ,equal p>ts ,mu* iod9 ,small am\nt ( ,no free iod9 ) #aj ,,ki1 imm$iately free iod9 9 9 #c h\rs #aj ,,kio few numb]s2 solution does n noticeably increase ,equal p>ts ,"s black5+2 ,r$di% mixture2 ,same ) conc4 odor ( ,h,cl no ,h,cl2 ,h,,s eucalyptol odor ,alcohol ,,ki ,no iod9 ,same ,same z ,abbott lib]at$ product ,heat+ ,decomposes & ,app>5tly does n boils at decompose2 "s #ajc-aje ,c42 gas giv5 (f !n high] :5 ,t#hj2 ! fraction comes liquid di/ill$ ov] at #agh ,c42 at #agc ,c42 ! di/illate has di/illate did %>p odor1 is n h mu* acid1 b frees odor2 no ,h,cl v little gas detect$2 ,i f ,,ki2 no ,i f di/illation ,,ki2 di/illate n complet$ 0 neutral 7di/illation n complet$7 ---------------------------------------- ------------------------------ ,! addition ( *lorlyptus to a mixture ( #aj p] c5t4 potassium iodide1 #aj p] c5t4 potassium iodate solution1 br+s ab\t ! lib]ation ( iod9e1 increas+ p]ceptibly on /&+4 ,?is %[s t ! hydrog5 *loride is gradually split (f1 & 9 "t w cause a solution hav+ a consid]able degree ( acidity4 ,:5 ?is te/ is c>ri$ out on *lor9at$ eucalyptol-,abbott1 a small am\nt ( iod9e is lib]at$ 9 a few m9utes b does n increase1 %[+ a slight initial acidity )\t fur!r hydrolysis4 ,*lor9at$ eucalyptol-,squibb yields no free iod9e aft] /&+ ?ree h\rs4 ,:5 ! *lor9e cont5t ( *lorlyptus is det]m9$ accord+ to ! me?od ( ,c>ius1 ! am\nt is f\nd to be #bi4f p] c5t4 7,! manufactur]s give a me?od ( det]m9+ *lor9e by ,hunt]'s fusion me?od4 ,x is believ$ t 9 ?is me?od hydrog5 *loride may be lo/1 & ?is op9ion is sub/antiat$ by ! firm's /atem5t1 8,*lorlyptus analyz$ 9 ?is mann] %[s approximately #be p] c5t4 ( *lor9e407 ,! *lor9e cont5t ( *lor9at$ eucalyptol-,abbott is f\nd to be #j4fg p] c5t41 & t ( ! ,squibb br& to be #j4fb p] c5t4 7ab\t "o-fiftie? z mu* z 9 *lorlyptus74 ,to sum up3 ,*lorlyptus diff]s f *lor9at$ eucalyptol 9 odor1 color1 d5sity1 9 reaction to silv] nitrate1 potassium iodide1 sulphuric acid & ! aque\s solution ( potassium iodate & potassium iodide4 ,! di/illation ( ! two products occurs diff]5tly4 ,*lorlyptus conta9s ne>ly #cj p] c5t4 ( *lor9e1 :i* is approximately fifty times z mu* z 9 *lor9at$ eucalyptol4 ,?us x appe>s to h consid]able *lor9e 9 ! negative =m 7,cl-7 :i* may be relatively easily split (f z hydrog5 *loride4 ,b4 ,,! ,,p]si/5ce ,,( ,,! ,,acid ,reaction ( ,*lorlyptus 9 ! ,body ,,by ,,! ,,ref]ee ,?is 8*lor9at$ ozoniz$ eucalyptus oil0 is di/9ctly acid to litmus pap]4 ,x is claim$ t fur!r quantities ( acid are lib]at$ on contact ) wat]4 ,?is is cr$it$ ) produc+ a cont9u\s acid reaction on ! surface ( tissues to :i* ! oil may be appli$ & ?is 9 turn is /at$ to be antiseptic or g]micidal4 ,?is !oretical speculation does n take into acc\nt ! l>ge quantity ( res]ve alkali 9 ! body by :i* x combats attempts to alt] its normal reaction4 ,x is !re=e n conv9c+1 unless x is support$ by direct evid5ce4 ,9 ! abs5ce ( su* data on ! "p ( ! promot]s ( ! prep>ation1 exp]im5ts 7 made to det]m9e :e!r ! oil pres]ves its acid reaction 9 contact ) muc\s & s]\s membranes4 ,! answ]s 7 cle>ly 9 ! negative4 ,9 ! m\?1 ! reaction becomes neutral )9 t5 or fifte5 m9utes2 9 ! pleura & p]itoneum )9 half an h\r1 & probably 9 mu* %ort] p]iods4 ,m detail$ data foll[3 ,,s]ies ,a3 ,,behavior ,,9 ,,! ,,m\?2 ,,homo ,,exp]im5t4--,*lorlyptus & to less ext5t ,*lorlyptus ,oil1 are acid to litmus4 ,!y are appli$3 7a7 ,drop to litmus pap] & ?is to gums4 7b7 ,sev]al drops directly to tongue4 7c7 ,same to gums4 ,! reaction to litmus pap] is tri$ f "t to "t4 ,,results4--7a7 ,appli$ to gums on litmus pap]3 ,*lorlyptus3 ,r$ color becomes gradually feebl] & does n spread on ! pap]4 ,*lorlyptus ,oil3 ,turns blue 9 a few m9utes4 7b7 ,dropp$ on tongue3 ,*lorlyptus3 ,acid ta/e at once4 ,does n increase1 b on contr>y1 becomes less4 ,litmus appli$ aft] t5 m9utes3 n acid4 ,litmus appli$ aft] five m9utes3 di/9ctly acid4 7c7 ,dropp$ on inside ( *eek3 ,*lorlyptus1 #a_/c c4c43 ,aft] six m9utes1 litmus v r$4 ,aft] t5 m9utes1 fa9tly r$4 ,aft] fifte5 m9utes1 blue4 ,*lorlyptus ,oil1 #a c4c4 ,aft] ?ree m9utes1 fa9tly r$4 ,aft] eight m9utes1 neutral4 ,,conclusions4--,on contact ) liv+ tissues1 ! acid ( *lorlyptus is rapidly neutraliz$ & absorb$4 ,! surface is neutral )9 t5 or fifte5 m9utes4 ,x is !re=e v improbable t ! acidity is effectively antiseptic4 ,a comp>ison ( *lorlyptus ) dilute acetic acid %[s t ! *lorlyptus does n ma9ta9 ! acidity ev5 z well z #a p] c5t4 acetic acid4 ,acetic ,acid ,*lorlyptus ,tongue1 a drop ( #e p] c5t42 /ill ,neutral betwe5 five slightly acid to litmus aft] t5 m9utes2 & t5 m9utes ta/e almo/ gone 9 two m9utes ,gums1 a few drops betwe5 *eeks & gums3 ,neutral betwe5 t5 ,five p] c5t4 /ill /rongly acid 9 & fifte5 m9utes twelve m9utes2 di/9ctly acid 9 sev5te5 m9utes4 ,"o p] c5t4 /ill /rongly acid 9 tw5ty-"o m9utes ---------------------------------------- ----------------------------- ,,*lorlyptus3 ,,reaction 7,,litmus ,,pap]7 ,,on ,,contact ,,) ,,tissue ,s]ial ,:5 ,quantity1 ,"t ,blue ,symptoms or ,no4 ,animal ,inject$ ,c4c4 ( ,dea? ,litmus ,toxicity #a ,rat ,pleura #a #a_/b h\r ,rema9s blue ,none2 kill$2 pleura n conge/$2 lung spec4 #ba2 slight conge/ion #b ,rat ,pleura #a #a h\r ,rema9s blue ,negative #c ,rat ,pleura #a #bc m94 ,rema9s blue ,almo/ at once bad gasp+ respiration & di$ 9 #bc m42 he>t di/5d42 possibly injection p5etrat$ lung ,p]itoneum #a #bc m94 ,turns r$ #d ,rabbit ,pleura #a 4444 444444 ,di$ ov]night #e ,dog ,pleura #a #a_/d h\r ,rema9s blue #bj m4 p4 m4 ,p]itoneum #a #a_/d h\r ,rema9s blue #bj m4 p4 m4 #f ,dog ,pleura #a #c m94 ,rema9s blue #de m4 p4 m4 ,p]itoneum #a #c m94 ,rema9s blue #de m4 p4 m4 #g ,dog ,pleura #a #bj m94 ,rema9s blue #bj m4 p4 m4 ,p]itoneum #a #bj m94 ,rema9s blue #bj m4 p4 m4 ,,s]ies ,b3 ,,s]\s ,,membranes ,9 ^! exp]im5ts1 #a c4c4 ( *lorlyptus 0 inject$ into ! pleura or p]itoneum4 ,aft] a /at$ "t1 ! animal 0 kill$1 & ! reaction ( ! pleural or p]itoneal surface 0 te/$ ) blue litmus pap]4 ,! results are %[n 9 ! table4 ,c4 ,,toxicity ,,exp]im5ts ,by ! ,ref]ee ,,te*nic ,:ite rats 7 inject$ hypod]mically ) *lorlyptus or ) eucalyptus oil1 dilut$ ) olive oil 9 ! ratio ( #a3d4 ,! l>g] doses 7 divid$ betwe5 two or m sites ( injection4 ,,detail$ ,,protocols ,hypod]mic injections 9 :ite rats4 ,drugs dilut$ ) #c p>ts ( olive oil4 ,doses are giv5 z cubic c5timet]s ( pure drug p] kilogram ( rat4 ,a4 ,,eucalyptus ,,s]ies ,,exp]im5t #a4--a4be c4c42 inject$ ,,vii4#i4ai3 ,active2 walks ab\t4 ,no depression at any "t4 ,,vii4#aj4ai4 ,appe>s normal4 ,,exp]im5t #b4--b4e c4c42 inject$ ,,vi4#cj4ai3 ,quiet--n v depress$1 reflexes good 7six h\rs74 ,,vii4#a4ai--;,active--reflexes good1 eats mod]ately4 ,,vii4#b4ai--;,animal acts normal--eats mod]ately1 reflexes good2 active 7a4m474 ,lat] 9 day1 depress$4 ,,vii4#d4ai--;,di$ dur+ night ( ,,vii4#c4ai4 ,,exp]im5t #c4--c4ge c4c42 inject$ ,,vi4#bd4ai3 ,quiet2 depress$2 pa9 reflex dim9i%$4 ,animal lay on v5tral surface1 n support$ by legs4 ,w get on to feet v sluggi%ly if turn$ on side 7tw5ty-f\r h\rs74 ,does n eat4 ,,vi4#bf4ai--;,depress$ slightly2 pa9 reflex pres5t4 ,,vi4#bg4ai--;,fairly active2 eats a little4 ,,vi4#bh4ai--;,depress$4 ,di$ dur+ night ( ,,vi4#bi4ai 7?ree days74 ,,exp]im5t #d4--e c4c42 inject$ ,,vi4#bd4ai3 ,quiet2 m>k$ly depress$ 7"o h\r74 ,does n get on feet :5 turn$ on side2 ataxia well m>k$4 ,slight wat]y secretion 9 eyes4 ,reflexes dim9i%$4 ,does n eat 7tw5ty-f\r h\rs74 ,,vi4#bf4ai--;,he>t sl[$ & arrhy?mic4 ,animal lies on side4 ,unable to walk2 m>k$ly depress$4 ,,vi4#bg4ai--,lies on side2 does n eat4 ,di$ dur+ night ( ,,vi4#bg4ai 7?ree days74 ,,exp]im5t #e4--f4be c4c42 inject$ ,,vi4#bd4ai3 ,quiet2 v m>k$ly depress$4 ,he>t & respiration greatly sl[$4 ,lies on side2 te>s 9 eyes2 does n eat 7tw5ty-f\r h\rs74 ,,vi4#be4ai--,temp]ature subnormal2 cold to t\*2 tail /iff5$ & /raight4 ,di$ dur+ night ( ,,vi4#be4ai 7"o & "o-half days74 ,po/mortem3 ,lungs conge/$4 ,liv] pale 9 color4 ,sple5 v d>k r$4 ,kidneys normal4 ,o!r organs normal4 ,b4 ,,*lorlyptus ,,exp]im5ts ,,exp]im5t #a4--a4ef c4c42 inject$ ,,vi4#bd4ai3 ,r re/less = an h\r4 ,active dur+ next f\r h\rs & foll[+ tw5ty-f\r4 ,eats well1 reflexes good4 ,acts normal on ,,vii4#a4ai & s9ce ,,vi4#bf4ai4 ,,exp]im5t #b4--c4ge c4c42 inject$ ,,vi4#bd4ai3 ,m quiet2 active dur+ next tw5ty-f\r h\rs4 ,reflex all "r4 ,eats well2 normal ,,vii4#a4ai1 s9ce ,,vi4#bf4ai4 ,,exp]im5t #c4--e c4c42 inject$ ,,vi4#bd4ai3 ,quiet2 defecation 9 f\r h\rs4 ,r quiet = six h\rs4 ,eats well4 ,reflexes good2 normal ,,vii4#a4ai1 s9ce ,,vi4#bf4ai4 ,,exp]im5t #d4--f4be c4c42 inject$ ,,vi4#bd4ai3 ,quiet & brea?+ labor$ 9 f\r h\rs2 active aft] tw5ty-f\r h\rs4 ,eats well4 ,some:at depress$ on ,,vi4#bf4ai2 pa9 reflex pres5t4 ,on ,,vi4#bf4ai1 eats well & fairly active4 ,active & eats1 ,,vi4#bg4ai4 ,appe>s normal1 ,,vii4#a4ai4 ,,exp]im5t #e4--h4ge c4c42 inject$ ,,vi4#cj4ai3 ,r quiet dur+ next two h\rs4 ,morn+ ( ,,vii4#a4ai1 lies on /oma*2 quiet2 does n eat v mu*4 ,pa9 reflexes good4 ,,vii4#b4ai1 /ill depress$2 does n eat4 ,appe>s normal1 ,,vii4#c4ai4 ,,exp]im5t #f4--ab4e c4c42 inject$ ,,vi4#be4ai3 ,quiet1 b reflexes good2 m quiet & depress$ aft] sev]al h\rs4 ,"s loss ( oil f w\nd4 ,di$ night ( ,,vi4#be4ai 7"o day74 ,tail /iff4 ,temp]ature l[4 ,po/mortem3 ,lungs m>k$ly conge/$4 ,sple5 & liv] d>k r$4 ,"o kidney conge/$4 ,o!r visc]a normal4 ,,exp]im5t #g4--ab4e c4c42 inject$ ,,vii4#i4ai3 ,quiet = "o-half h\r2 #a4e h\rs twit*+ ( muscles ( :ole body1 lies on side1 ataxia pres5t4 ,di$ night ( ,,vii4#i4ai 7"o day74 ,,exp]im5t #h4--ah4ge c4c42 inject$ ,,vi4#be4ai3 ,quiet2 reflexes good 7?ree h\rs74 ,"s loss ( oil4 ,depress$ & turns on side 7six h\rs74 ,di$ night ( ,,vi4#be4ai 7"o day74 ,po/mortem3 ,lungs conge/$4 ,sple5 & liv] v d>k r$4 ,"r kidney mu* d>k] r$4 ,visc]a normal4 ,d4 ,,report ,,( ,,dr4 ,d4 ,,rivas ,! foll[+ are ! results ( exp]im5ts conduct$ by me1 dur+ ! pa/ f\r mon?s1 on ! g]micidal action ( *lorlyptus 7*lor9at$ oil ( eucalyptus1 pr9cipal con/itu5t ,c,h,o,cl7 9 vitro & 9 vivo1 & comp>ison also ) c>bolic acid1 oil ( eucalyptus & di*loram9e 9 te/ = irritation & toxicity4 ,g]micidal ,action4--,bas$ on ! results obta9$1 *lorlyptus :5 us$ 9 a #e p] c5t4 p>aff9 oil solution 0 f\nd to be a mild g]micidal aga9/ typhoid ,b1 /reptococcus & /aphylococcus :5 ^! organisms 7 susp5d$ 9 ord9>y b\illon culture or /]ile salt solutions4 ,! g]micidal action 0 f\nd /rong] :5 ^! micro-organisms 7 susp5d$ 9 a /]ile oily or lipoid sub/ance1 su* z olive oil4 ,! results ( ^! exp]im5ts 7 n con/ant1 ow+ probably to ! imp]fect susp5sion ( ! bact]ia4 ,?us1 :ile 9 "s ( ! exp]im5ts *lorlyptus 9 #a p] c5t4 oil solution de/roy$ ^! micro-organisms1 9 o!r cases ! same /r5g? solution fail$ to give same result 9 same "t4 ,! increas$ g]micidal action ( *lorlyptus on bact]ial susp5sions 9 olive oil may be acc\nt$ = by ! fact t *lorlyptus is soluble 9 olive oil & n an admixture1 z 9 ! case ( p>aff9 oil4 ,*lorlyptus is n a coagulant1 z are g]micides ( ! ph5ol or hypo*lorite types1 & ! g]micidal action is !re=e n /rictly comp>able4 ,! g]micidal action ( *lorlyptus oil solution1 on pa?og5ic bact]ia1 on /reptococcus & /aphylococcus1 susp5d$ 9 pus1 0 f\nd to be /rong] ?an :5 ^! micro-organisms 7 susp5d$ 9 ord9>y b\illon culture or /]ile salt solution4 ,9 "o ( ! exp]im5ts1 simil> results 7 obta9$ :5 ^! micro-organisms 7 susp5d$ 9 olive oil1 *lorlyptus %[+ m>k$ g]micidal action4 ,irritation & ,toxicity4--,! irritat+ action 0 f\nd to be relatively mild 9 te/s on laboratory animals4 ,?us1 f #j4e to #a c4c4 ( *lorlyptus 9 p>aff9 oil #e p] c5t4 solution1 inject$ into p]itoneal or pleural cavities ( gu9ea-pigs weigh+ #djj gm4 0 f\nd to be )\t any appreciable di/urbance 9 ! heal? ( ! animal1 & 9 "s cases ! injection ( z mu* z #b c4c4 did n kill ! animal4 ,!rapeutic ,action4--,gu9ea-pigs 7 inoculat$ ) purul5t mat]ial conta9+ /reptococcus1 /aphylococcus & ,b4 coli 9 p]itoneal & pleural cavities respectively1 & aft] six h\rs #a c4c4 ( *lorlyptus #e p] c5t4 9 p>aff9 oil solution 0 inject$4 ,o!r infect$ animals 7 simil>ly treat$ tw5ty-f\r h\rs aft] inoculation1 & ano!r s]ies =ty-eight h\rs aft] inoculation4 ,9 "s ( ^! cases ! animals di$ f %ock b 9 a cle>ly def9$ s]ies 9 :i* ! injection ( #a c4c4 ( ! *lorlyptus solution 0 made 9 ! p]itoneum ( ! gu9ea-pigs tw5ty-f\r h\rs aft] ! inoculation1 ! animals liv$4 ,! control animal1 inoculat$ ) ! purul5t mat]ial & n treat$ ) *lorlyptus oil solution1 di$4 ,9 consid]ation t ! injection ( *lorlyptus oil solution sic1 ref]ee 7 made 8 ref]ee 9 ! p]itoneal cavity ?is sub/ance is apt to affect ! vital organs 9 ! abdom9al cavity4 ,x is my belief t 9 case ( wall abscess ( *ronic inflammation1 by limit+ ! action ( *lorlyptus to ! infect$ area1 prev5t+ at ! same "t ! infection ( ! vital organs1 *lorlyptus1 because ( its non-irritat+ quality1 c be us$ effectively z an antiseptic4 ,,conclusions #a4 ,*lorlyptus is a mild & relatively nonirritat+ antiseptic ( m>k$ action on pus & suppuration4 #b4 ,:5 bact]ia 7 susp5d$ 9 olive oil or 9 pus1 *lorlyptus %[$ m>k$ g]micidal action4 #c4 ,*lorlyptus c be inject$ into ! p]itoneum or ! pleural cavities ( gu9ea-pigs 9 ! proportion ( #a c4c4 p] #djj gm4 ( body weight )\t detrim5t to ! animal4 #d4 ,*lorlyptus 9 #e p] c5t4 oil solution 7tak+ ,clause #c z comp>ison7 c p]haps be inject$ 9 man z an antiseptic ag5t :5 !re is a wall$-9 abscess 9 ! p]itoneum or pleural cavity :]e !re is dra9age1 9 ! proportion ( #j4e to #a c4c4 p] p\nd ( body weight ) good result4 ,,report ,,on ,,! ,,g]micidal ,,action ,,( ,,*lorlyptus ,,on ,,pa?og5ic ,,bact]ia ,,9 ,,vitro ,,& ,,9 ,,vivo ,,exp]im5t #a4--,! g]micidal action ( eucalyptus oil4--,typhoid bacillus 0 de/roy$ 9 less ?an five m9utes :5 expos$ to ! action ( a #e p] c5t4 susp5sion ( oil ( eucalyptus4 ,! exposure = f\r h\rs 9 a #e p] c5t4 susp5sion ( *lorlyptus 9 p>aff9 oil 0 )\t effect on typhoid bacillus4 ,x requires an exposure ( two to f\r h\rs 9 a #aj p] c5t4 susp5sion ( *lorlyptus 9 p>aff9 oil to de/roy typhoid bacillus4 ,,exp]im5t #b4--;,bacilli>y action ( *lorlyptus on ! gr[? ( pa?og5ic bact]ia4--,typhoid & an?rax bacilli 7 select$ = ! exp]im5t4 ,two s]ies ( five tubes ea* 7 made4 ,! culture m$ium us$ 0 nutri5t b\illon4 ,*lorlyptus 0 add$ 9 ! foll[+ proportions3 ,tube #a1 #a3aj2 ,tube #b1 #a3ajj2 ,tube #c1 #a3a1jjj2 ,tube #d1 #a3aj1jjj1 & ,tube #e1 #a3ajj1jjj4 ,"o s]ies 0 inoculat$ ) typhoid bacillus4 ,all tubes 7 incubat$ = ?ree days at #cg ,c4 ,*lorlyptus inhibit$ ! gr[? ( typhoid bacillus :5 add$ to ! b\illon 9 ! proportions ( #a3aj4 ,! gr[? ( an?rax bacillus 0 inhibit$ by *lorlyptus :5 x 0 add$ 9 ! proportions ( #a3aj1 #a3ajj & #a3a1jjj1 z %[n 9 ! accompany+ table4 ,! table 0 n submitt$4--,ed4 ,9 "o in/ance ! gr[? 0 m>k$ly inhibit$ by *lorlyptus :5 add$ 9 ! proportion ( #a3aj1jjj4 ,,exp]im5t #c4--;,g]micidal action ( *lorlyptus on typhoid bacillus4--,b\illon cultures ( typhoid bacillus =ty-eight h\rs old1 & a susp5sion ( =ty-eight-h\r ag> cultures ( typhoid bacillus 9 /]ile salt solution 7 us$ = ! exp]im5t4 ,*lorlyptus 0 add$ 9 ! proportion ( #a3a1jjj2 #a3a1ejj2 #a3ajj2 #b p] c5t42 #c p] c5t42 #d p] c5t42 #e p] c5t4 & #aj p] c5t41 respectively4 ,inoculations 7 made 9 tryps9iz$ peptone b\illon aft] ! addition ( *lorlyptus at diff]5t int]vals1 namely3 at once1 aft] five m9utes1 aft] t5 m9utes1 aft] fifte5 m9utes1 aft] ?irty m9utes1 aft] "o h\r & aft] two h\rs1 & tubes incubat$ at #cg ,c4 = =ty-eight h\rs4 ,result3 ,gr[? 0 %[n 9 all tubes except ^? 9 :i* *lorlyptus 0 add$ 9 ! proportion ( #aj p] c5t4 & aft] ! action ( ! antiseptic = two h\rs or long]4 ,,exp]im5t #d4--;,inhibitory action ( *lorlyptus 9 ! gr[? ( typhoid bacillus4--,*lorlyptus 0 add$ to /]ile b\illon 9 ! proportion ( #a3ajj1 #a3a1jjj1 #a3aj1jjj & #a3ajj1jjj1 & incubat$ = =ty-eight h\rs at #cg ,c4 to elim9ate any possible contam9ation ( ! b\illon dur+ ! manipulations4 ,all tubes 7 f\nd /]ile & inoculat$ ) typhoid bacillus4 ,result3 ,all tubes 7 f\nd /]ile aga9 aft] be+ inoculat$ ) typhoid bacillus & incubat$ at #cg ,c4 = =ty-eight h\rs1 :i* %[s *lorlyptus inhibit$ & ! gr[? ( typhoid bacillus 9 b\illon :5 ?is antiseptic 0 add$ 9 ! proportions ( #a3ajj to #a3ajj1jjj4 ,rem>ks3 ,9 ano!r exp]im5t made1 *lorlyptus %[$ a weak] inhibitory action on ! gr[? ( typhoid bacillus4 ,,exp]im5t #e4--;,g]micidal action ( c>bolic acid4--,! te*nic 0 ! same z t outl9$ 9 ,exp]im5t #a4 except t c>bolic acid 0 us$ in/ead ( *lorlyptus4 ,result3 ,c>bolic acid %[$ a di/9ct g]micidal action on typhoid bacillus 9 ! proportions ( #a p] c5t4 9 t5 m9utes4 ,,exp]im5t #f4--;,action ( nitrog5 gas on ! gr[? ( typhoid bacillus 9 b\illon & nutri5t ag> :5 *lorlyptus 0 add$ to ?is culture m$ium4--,*lorlyptus 0 add$ to ! b\illon 9 ! proportions ( #a3ajj1 #a3a1jjj1 #a3aj1jjj & #a3ajj1jjj1 z outl9$ 9 ,exp]im5t #b2 also to ag> kept melt$ at #de ,c4 ,tubes 7 inoculat$ ) typhoid bacillus2 plates 7 made ( ! inoculat$ ag> tubes2 all plates & tubes 7 incubat$ at #cg ,c4 = =ty-eight h\rs 9 an atmosph]e ( nitrog5 gas4 ,duplicate exp]im5ts 7 made ) cultures ( typhoid bacillus z above 9 b\illon & ag> plates conta9+ ! same am\nt ( *lorlyptus & incubat$ at #cg ,c4 9 ord9>y atmosph]e z control4 ,result3 ,nitrog5 gas did n %[ any appreciable increase ( ! g]micidal action ( typhoid bacillus :5 gr[n 9 m$ium conta9+ *lorlyptus4 ,gr[? 0 ab\t ! same 9 cultures suppli$ ) nitrog5 gas z 9 ^? gr[+ 9 ord9>y atmosph]e4 ,,exp]im5t #g4--;,g]micidal action ( *lorlyptus on pyog5ic bact]ia susp5d$ 9 an oily m$ium4--,exp]im5t ) /reptococcus3 ,cultures ( /reptococcus 9 blood ag> ?ree days old 7 susp5d$ 9 olive oil 7/]ile71 & *lorlyptus 0 add$ 9 ! proportions ( #a1 #e & #aj p] c5t4 & inoculat$ 9 tryps9iz$ b\illon at diff]5t int]vals1 namely3 at once1 aft] five m9utes1 aft] t5 m9utes1 aft] fifte5 m9utes1 aft] ?irty m9utes1 & aft] "o h\r4 ,tubes 7 incubat$ at #cg ,c4 = =ty-eight h\rs4 ,result3 ,all tubes rema9$ /]ile4 ,! g]micidal action ( *lorlyptus on /reptococcus susp5d$ 9 oil 0 almo/ at once & ) c]ta9ty aft] five m9utes :5 add$ 9 ! proportion ( #a1 #e & #aj p] c5t4 ,,exp]im5t #h4--;,g]micidal action ( *lorlyptus on /aphylococcus1 susp5d$ 9 /]ile olive oil4--,! te*nic employ$ 0 ! same z 9 ,exp]im5t #e1 except t a culture ( /aphylococcus 0 us$4 ,result3 ,all tubes rema9$ /]ile4 ,! g]micidal action ( *lorlyptus 0 almo/ at once 9 ! proportions ( #a1 #e & #aj p] c5t4 ,rem>ks3 ,by repeat+ ?is exp]im5t ! result %[$ "s v>iations4 ,! discrepancy 0 probably due to an imp]fect susp5sion ( ! micro-organism 9 ! oil4 ,,exp]im5t #i4--;,g]micidal action ( c>bolic acid on /reptococcus susp5d$ 9 olive oil4--,! te*nic employ$ 0 ! same z 9 ,exp]im5t #e1 except t c>bolic acid 0 us$ in/ead ( *lorlyptus4 ,result3 ,! g]micidal action ( c>bolic acid ( /reptococcus susp5d$ 9 olive oil 0 almo/ at once 9 ! proportions ( #a1 #e & #aj4 ,,exp]im5t #aj4--;,g]micidal action ( *lorlyptus on /aphylococcus4--,! te*nic employ$ 0 ! same z 9 ,exp]im5t #f except t ! c>bolic acid 0 us$ in/ead ( *lorlyptus4 ,result3 ,! g]micidal action ( c>bolic acid on /aphylococcus susp5d$ 9 olive oil 0 almo/ at once1 9 proportions ( #a1 #e & #aj p] c5t4 ,,exp]im5t #aa4--;,g]micidal action ( *lorlyptus on pyog5ic bact]ia susp5d$ 9 pus4--,*lorlyptus 0 add$ to /]ile pus 9 ! proportions ( #a1 #e & #aj p] c5t41 & !n inoculat$ ) /aphylococcus & cultures 7 made 9 b\illon at once1 aft] five m9utes1 aft] t5 m9utes1 aft] fifte5 m9utes1 aft] ?irty m9utes1 aft] "o h\r & aft] two h\rs1 respectively1 & tubes incubat$ = =ty-eight h\rs at #cg ,c4 ,result3 ,gr[? 0 %[n 9 all tubes except ^? inoculat$ f tubes 9 :i* *lorlyptus 0 add$ 9 ! proportions ( #aj p] c5t4 aft] "o h\r4 ,,exp]im5t #ab4--;,g]micidal action ( *lorlyptus on /reptococcus susp5d$ 9 /]ile human blood s]um4--,/aphylococcus culture 9 ag> =ty-eight h\rs old 0 susp5d$ 9 /]ile human blood s]um1 & to ! susp5sion *lorlyptus #e p] c5t4 9 p>aff9 oil 0 add$ 9 ! proportions ( #a1 #e & #aj p] c5t4 ,inoculations 7 made at int]vals1 at once1 aft] five m9utes1 aft] t5 m9utes1 aft] fifte5 m9utes & aft] "o h\r 9 tryps9iz$ b\illon4 ,tubes 7 incubat$ at #cg ,c4 = =ty-eight h\rs4 ,result3 ,*lorlyptus %[$ inhibitory action on ! gr[? ( /aphylococcus 9 ! /r5g? ( #aj p] c5t41 b did n produce complete /]ilization4 ,simil> results 7 %[n ) ! #e p] c5t41 & 9 ! #a p] c5t4 *lorlyptus did n %[ any inhibitory action at all4 ,,exp]im5t #ac4--;,g]micidal action ( c>bolic acid on /aphylococcus susp5d$ 9 human blood s]um 7/]ile74--,! te*nic employ$ 0 ! same z 9 ,exp]im5t #aj except t c>bolic acid 0 us$ in/ead ( *lorlyptus4 ,result3 ,c>bolic acid produc$ a complete /]ilization 9 ! /r5g? ( #aj p] c5t4 almo/ at once1 & ) c]ta9ty aft] five m9utes4 ,simil> results 7 produc$ ) ! #e p] c5t4 ,! #a p] c5t4 c>bolic acid did n %[ any appreciable g]micidal action on /aphylococcus4 ,,exp]im5t #ad4--,toxic & irritant action ( *lorlyptus4--,six normal gu9ea-pigs 7 us$ = ! exp]im5t4 ,gu9ea-,pig #a 0 inject$ p]itoneally ) #a c4c4 ( *lorlyptus1 ,gu9ea-,pig #b ) #b c4c4 ( *lorlyptus1 ,gu9ea-,pig #c ) #c c4c4 ( *lorlyptus1 ,gu9ea-,pig #d ) #d c4c4 & ,gu9ea-,pig #e ) #e c4c4 #e p] c5t4 respectively4 ,gu9ea-,pig #f 0 us$ z a control & n inject$4 ,result3 ,gu9ea-,pigs #a & #b did n %[ any appreciable di/urbance4 ,gu9ea-,pig #c 0 sick = f\r days1 aft] :i* x gradually recov]$ b x became sick aga9 aft] "o week & di$ t5 days aft] ! injection4 ,gu9ea-,pig #d di$ ov] night4 ,gu9ea-,pig #e di$ six h\rs aft] injection4 ,gu9ea-,pig #e 0 inject$ at #aa3cj ) #e c4c4 *lorlyptus4 ,t5 m9utes aft] ! injection x 0 ly+ relax$1 respiration & he>t normal1 conjunctive reflex pres5t4 ,"o h\r aft] ! injection ! animal seem$ to pres5t symptoms resembl+ ^? ( n>cosis3 respiration & he>t 7 normal4 ,aft] f\r h\rs !re 0 no *ange 9 ! condition ( ! gu9ea-pig except t ! respiration 0 irregul>4 ,five & a half h\rs aft] x %[$ pro/ration ) irregul> respiration & he>t action4 ,six h\rs aft] injection ! animal 0 dead4 ,autopsy3 ,! p]itoneum %[$ a conge/ion & a fibr9\s exudation1 am\nt ( liquid increas$1 "s "p ( :i* 0 probably *lorlyptus unabsorb$4 ,sple5 ab\t normal1 liv] conge/$1 kidney ab\t normal1 supr>5al gl&s ab\t normal1 lungs normal1 pleural cavity obta9$ no exudation1 he>t s(t1 flabby & conge/$4 ,,exp]im5t #ae4--,toxic & irritant action ( *lorlyptus :5 inject$ into ! pleural cavity4--,six normal gu9ea-pigs us$ = ! exp]im5t4 ,*lorlyptus 0 inject$ 9 ! pleural cavity z foll[s3 ,gu9ea-,pig #a1 #j4e c4c42 ,gu9ea-,pig #b1 #a c4c42 ,gu9ea-,pig #c1 #b c4c42 ,gu9ea-,pig #d1 #c c4c41 & ,gu9ea-,pig #e1 #d c4c4 ,gu9ea-,pig #f 0 us$ z a control4 ,result3 ,gu9ea-,pigs #a & #b recov]$ ab\t f\r h\rs aft] injection4 ,gu9ea-,pig #c di$ ?ree days aft] & ,gu9ea-,pigs #d & #e f\r & two h\rs aft]1 respectively4 ,conclusions3 ,gu9ea-pigs weigh+ on ! av]age ( #djj gm4 may be inject$ p]itoneally ) "o or two c4c4 or intrapleurally ) #j4e to #a c4c4 ( *lorlyptus )\t hav+ fatal results f ! injection4 ,,exp]im5t #af4--,toxic & irritant action ( eucalyptus oil4--,?ree normal gu9ea-pigs 7 us$ = ! exp]im5t4 ,gu9ea-,pig #a 0 inject$ ) #a c4c4 ( oil ( eucalyptus 9 ! p]itoneum1 & ,gu9ea-,pig #b ) #j4e c4c4 9 ! pleural cavity4 ,gu9ea-,pig #c 0 us$ z a control4 ,result3 ,gu9ea-,pig #a di$ ab\t ?ree h\rs aft] injection1 & ,gu9ea-,pig #b ab\t two h\rs aft] ! injection4 ,autopsy3 ,bo? gu9ea-pigs %[$ m>k$ conge/ion & a mod]ate degree ( exudate 9 ! p]itoneum4 ,,exp]im5t #ag4--,toxic & virul5t action ( eucalyptus4--,?ree normal gu9ea-pigs 7 select$ = ! exp]im5t1 z 9 ,exp]im5t #af4 ,! injection 0 made 9 ! pleural cavity4 ,gu9ea-,pig #a 0 inject$ ) #j4e c4c4 & ,gu9ea-,pig #b ) #a c4c4 ( eucalyptus oil4 ,result3 ,gu9ea-,pig #a di$ ! foll[+ day1 & ,gu9ea-,pig #b "o h\r aft] ! injection4 ,,exp]im5t #ah4--,toxic & irritant action ( di*loram9-,t1 #j4e p] c5t4 9 *lorcozane4--,"o gu9ea-pig 0 us$ = ea* exp]im5t4 ,gu9ea-,pig #a 0 inject$ ) #j4e c4c4 & ,gu9ea-,pig #b ) #a c4c4 ( di*loram9-,t p]itoneally4 ,result3 ,bo? animals became re/less imm$iately aft] ! injection1 & di$ twelve h\rs aft] ( acute hemorrhagic p]itonitis4 ,,exp]im5t #ai4--;,effect ( *lorlyptus on /aphylococcus susp5d$ 9 salt solution & "o ( t solution inject$ into ! p]itoneum ( ! gu9ea-pig4--,?ree gu9ea-pigs 7 us$ = ! exp]im5t4 ,gu9ea-,pig #a 0 inject$ ) #j4e c4c4 ( /aphylococcus susp5sion z control4 ,gu9ea-,pig #b 0 giv5 ! same1 & imm$iately aft] receiv$ #a c4c4 ( *lorlyptus4 ,gu9ea-,pig #c 0 inject$ ) ! same am\nt1 & *lorlyptus 0 inject$ tw5ty-f\r h\rs aft] injection4 ,results3 ,gu9ea-,pig #a 0 sick & weak ) loss ( appetite = "s days1 b gradually recov]$4 ,gu9ea-,pig #b di$ ov] night4 ,autopsy3 ,!re 0 a l>ge am\nt ( exudate 9 ! p]itoneal cavity1 irritation ( ! inte/9e1 & o!r signs ( acute inflammation4 ,a mod]ate degree ( conge/ion2 sple5 n enl>g$2 liv] %[$ cl\dy swell+ & fibr9\s exudate2 lungs & he>t ab\t normal except = a mod]ate degree ( conge/ion b no exudate4 ,gu9ea-,pig #c 0 sick = "s days1 b recov]$ gradually "o week aft]4 ,,exp]im5t #bj4--;,effect ( *lorlyptus 9 vivo on /aphylococcus4--,! exp]im5t 0 conduct$ 9 ! same way z 9 ,exp]im5t #ag1 b #b c4c4 7 us$ in/ead ( #a c4c4 ,result3 ,gu9ea-,pig #a 0 inject$ ) #b c4c4 /aphylococcus susp5sion & di$ ov] night4 ,autopsy %[$ t ! animal di$ ( acute p]itonitis4 ,! p]itoneum %[$ "s fibr9\s exudate & mes5t]ic vessels4 ,gu9ea-,pig #b 0 inject$ ) #b c4c4 ( /aphylococcus1 & eighte5 h\rs aft] 0 inject$ ) #a c4c4 ( *lorlyptus4 ,! animal di$ two weeks aft] injection4 ,gu9ea-,pig #c 0 inject$ ) #b c4c4 /aphylococcus susp5sion1 & tw5ty-f\r h\rs aft] ) #a c4c4 ( *lorlyptus4 ,! ,gu9ea-,pig di$ t5 days aft]4 ,autopsy reveal$ bron*opneumonia ( ! left lung & acute mili>y abscess 9 ! liv]4 --7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #bg1 #aibj1 ) additions47 ,,aquazone 7,,oxyg5 ,,wat]7 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,aquazone is /at$ by ! ,aquazone ,laboratories1 ,inc41 ,los ,angeles1 ,cali=nia1 to be a sup]saturat$ solution ( oxyg5 9 wat]1 c>ry+ approximately five & "o-half times z mu* dissolv$ oxyg5 z ord9>y wat]4 ,9 an adv]tis+ booklet1 x is sugge/$ t ,aquazone is ( value 9 ! treatm5t ( influ5za1 pneumonia1 typhoid1 ,bright's disease & k9dr$ disord]s4 ,x 0 also /at$ !re9 t 9 ! treatm5t ( fev]s x l[]s ! temp]ature1 & t ! adm9i/ration ( ?ree bottles ( ,aquazone 7repres5t+ #j4jcc gm4--#a-a_/b gra9--( oxyg57 is ( value = 8prev5tive & tonic purposes40 ,! evid5ce :i* ! ,aquazone ,laboratories submitt$ did n %[ t ! effects 7 o!r ?an ^? :i* might be obta9$ f ! adm9i/ration ( ord9>y potable wat]4 ,! ,c\ncil decl>$ ,aquazone inadmissible to ,new & ,non(ficial ,rem$ies1 because ! !rapeutic claims made = x 7 unw>rant$1 & because its use is irrational = ! reason t oxyg5 giv5 by /oma* 9 ?is way is ( little or no value4--7,ab/ract$ f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aibj1 p4 #ej47 ,,coagul5-,,ciba ,,omitt$ ,,f ,n4 ,n4 ,r4 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has au?oriz$ publication ( ! foll[+ report ann\nc+ ! deletion ( ,coagul5-,ciba f ,new & ,non(ficial ,rem$ies4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,coagul5-,ciba1 a product ( ! ,society ( ,*emical ,indu/ry1 ,basle1 ,switz]l&1 0 admitt$ to ,new & ,non(ficial ,rem$ies 9 #aiae4 ,x is /at$ to be an extract prep>$ f blood platelets & to conta9 ?rombopla/ic sub/ances 7cytozym1 ?rombok9ase1 ?rombozym7 mix$ ) lactose4 ,ext5sive cl9ical reports appe>$ to ju/ify its acceptance = ,new & ,non(ficial ,rem$ies ) ,fibr9 ,f]m5ts & ,?rombopla/ic sub/ances4 ,9 #aiah1 ,dr4 ,ar?ur ,d4 ,hirs*feld] report$ to ! ,c\ncil t ( a numb] ( specim5s ( ,coagul5-,ciba exam9$ by him1 fail$ to accel]ate ! coagulation "t ( blood4 ,9 view ( ,dr4 ,hirs*feld]'s f9d+s1 ! ,!rapeutic ,rese>* ,committee ( ! ,c\ncil invit$ ,dr4 ,p4 ,j4 ,hanzlik to und]take an exhau/ive inve/igation ( ?rombopla/ic sub/ances1 ! ,c\ncil1 9 ! meantime tempor>ily reta9+ ,coagul5 9 ,new & ,non(ficial ,rem$ies until ! inve/igation 0 complet$4 ,! foll[+ report on ! eligibility ( ,coagul5-,ciba 0 made to ! ,c\ncil by ,dr4 ,hanzlik3 ,object3 ,to te/ ! claims ( ?rombopla/ic & hemo/atic activities4 ,claims3 ,coagul5 is alleg$ to be a 8physiological /yptic prep>$ f ! natural coagulants ( animal food conta9$ 9 ! blood platelets4 ,x has ! *>act]i/ics ( a lipoid40 7,if cephal9 is meant x is difficult to und]/& :y platelets %\ld be select$ 9 pref]5ce to o!r abundantly suppli$ organs su* z bra9s74 8,coagul5 is indicat$ 9 all cases ( ext]nal & int]nal hemorrhage due to a defici5cy ( ! coagulat+ p[] ( ! blood3 epi/axis1 hemophilia1 hemorrhage f ga/ric or duod5al ulc]1 mela5a neonatorum1 hemorrhage f ! gums1 ! lungs1 ! bladd]1 ! ut]us1 hemorrhage dur+ or aft] op]ations 7turb9ectomy1 tonsillectomy74 ,x has also be5 us$ z a prophylactic be=e op]ations1 likely to produce sev]e hemorrhage40 8,9 cases ( true hemophilia "o application ( #e gra9s ( coagul5 usually suffices to control ! hemorrhage40 8,9 ga/ric & inte/9al hemorrhage ! int]nal adm9i/ration ( coagul5 w be f\nd effective40 8,9 bonegraft+1 pla/ic surg]y1 d5ti/ry & nose & ?roat surg]y ! application ( a #aj p] c5t4 solution ( ,coagul5 w be f\nd to be ( valuable assi/ance 9 controll+ hemorrhage & ooz+40 8,x is a non-toxic & non-irritat+ p[d] to :i* a c]ta9 am\nt ( sug> has be5 add$1 ) a view to ensur+ its prompt solution 9 wat] or physiological sodium *loride solution40 ,description3 8,coagul5 is a yell[i% granul> p[d] ) b slight odor1 a sweet ta/e & is readily soluble 9 wat] or a normal salt solution40 ,! dry ,coagul5 obta9$ corresponds to ! description claim$4 ,old specim5s %[ ! pres5ce ( d>k br[n p>ticles4 ,coagul5 is m>ket$ 9 #c =ms3 7#a7 z dry p[d] conta9+ lactose1 :i*1 x is claim$1 facilitates solution 9 wat]2 7#b7 z #c p] c5t4 /]ile solution 9 amp\les2#acg 7#c7 tablets4 #acg ,an amp\le label$ z foll[s3 8,coagul5-,ciba1 #bj c4c4 9 /]ile solution ready = use4 ,to be %ak54 ,import de ,suisse4 ,op4 ,no4 #ifh0 0 f\nd to measure only #ae c4c4 ,ano!r amp\le ) ! same label & ,op4 ,no4 #ifda conta9$ consid]able s$im5t4 ,me?ods ( ,/udy3 ,! alleg$ ?rombopla/ic activity 0 te/$ by ! me?od ( ,h[ell & a modification ( ?is me?od by ,f5g] z describ$ 9 8,new & ,non(ficial ,rem$ies40 ,9 ! ,h[ell me?od dog or cat blood is us$1 :ile beef blood at body temp]ature is us$ 9 ,f5g]'s me?od4 ,9 o!r respects ! me?ods are ess5tially ! same4 ,briefly ^! consi/ ( not+ ! accel]ation ( coagulation "t 9 a mixture ( equal p>ts ( s]um & ! ?rombopla/ic ag5t to :i* ab\t an equal "p ( oxalate plasma is add$4 ,"u ^! conditions cephal9 causes clott+ 9 ab\t #a m9ute or ev5 less z comp>$ ) #bj to #cj m9utes or m ( ! control4 ,! effects 7 comp>$ ) fre%ly prep>$ cephal9 & o!r ?rombopla/ic ag5ts1 us+ sal9e 7#j4i p] c5t4 ,na,cl7 z control4 ,! effect ( diff]5t conc5trations 0 also /udi$4 ,! lit]ature ( ! manufactur]s claims t ,coagul5 is h>mless4 ,?is 0 te/$ by mak+ intrav5\s & subcutane\s injections into gu9ea-pigs1 us+ sal9e & cephal9 z controls4 ,bloods ( #d diff]5t species 7 us$1 namely1 cat1 dog1 beef & human4 ,dog's peptoniz$ blood & plasma 7 also tri$4 ,! #ae diff]5t te/s t 7 made 9 vitro 7 c>ri$ out ) #c diff]5t samples ( fre% dry ,coagul5 7f manufactur]71 #b old samples 7"o f ,c\ncil on ,ph>macy & ,*emi/ry & "o ( our own71 #c fre% specim5s ( /]ile solution 9 amp\les 7f manufactur]71 "o old specim5 & #d small amp\les 7,c\ncil on ,ph>macy & ,*emi/ry74 ,! tablets 7 n te/$ s9ce ^! are made f dry ,coagul5 & ! results w\ld h>dly be expect$ to %[ any?+ diff]5t4 ,results3 ,! results obta9$ may be briefly summ>iz$ z foll[s3 7#a7 #j4a p] c5t4 to #e p] c5t4 ,coagul5 did n accel]ate ! coagulation "t ( blood & oxalate plasmas 9 ! majority ( te/s any m ?an ! controls ( sal9e1 :ile #j4a p] c5t4 cephal9 0 f\nd to %ort5 ! coagulation "t f #a_/c to #a_/b4 7#b7 ,!re 0 no diff]5ce betwe5 ! behavior ( old & fre% specim5s4 7#c7 ,no accel]ation ( coagulation 9 vitro 0 obs]v$ ev5 ) ! highe/ conc5trations tri$1 namely #be & #ej p] c5t4 7#d7 ,irrigations made ) fre% dry coagul5 9 solution & /]ile solution 9 amp\les on sup]ficial ble$+ f ! foot-pads ( #c normal & peptoniz$ dogs & local application to hemorrhages f dissect$ femoral art]ies & bone & liv] w\nds ( #c dogs %[$ t coagul5 0 no m active ?an normal sal9e4 ,toxicity3 ,subcutane\s & intrav5\s injections ( diff]5t doses ( ,coagul5 solutions 7fre% amp\les7 & dry ,coagul5 9 solution 9 #h gu9ea-pigs produc$ def9ite anaphylactoid symptoms ) injury to ! circulatory & respiratory sy/ems z indicat$ by c>diac dilatation1 abdom9al conge/ion & pulmon>y hemorrhages1 conge/ion1 di/5tion & sometimes ?rombi4 ,on ! o!r h&1 ! control animals inject$ ) sal9e & cephal9 rema9$ practically unh>m$4 ,conclusions3 ,! results obta9$ ju/ify ! foll[+ conclusions3 7#a7 ,coagul5 is entirely inactive z a ?rombopla/ic & hemo/atic ag5t4 7#b7 ,coagul5 is di/9ctly injuri\s :5 inject$ sy/emically4 7#c7 ,! claims ( hemo/atic effici5cy & h>mlessness = ,coagul5 by ! manufactur] appe> exagg]at$ & unju/ifi$4 ,recomm5dations3 ,because ( its unc]ta9 composition1 ! possible dang]s :5 inject$ sy/emically1 & its inactivity z a ?rombopla/ic & hemo/atic ag5t :5 te/$ by sev]al diff]5t me?ods1 ,coagul5 m]its no recognition z a !rapeutic ag5t = inclusion 9 ,new & ,non(ficial ,rem$ies4 ,! detail evid5ces us$ z ! basis ( ?is brief report conc]n+ ,coagul5 w be publi%$ %ortly 9 ! ,j\rnal ( ,ph>macology1#ach toge!r ) ! results ) o!r ?rombopla/ic ag5ts4 #ach ,s9ce ! report 0 s5t to ! manufactur]s1 ! results h be5 publi%$4 ,hanzlik1 ,p4 ,j41 & ,weid5?al1 ,c4 ,m41 ,plasma & ,blood ,clott+ ,effici5cy ( ,?rombopla/ic ,ag5ts 9 ,vitro & _! ,/ability1 ,j4 ,ph>macol4 & ,exp]4 ,!rap4 #ad3aeg 7,octob]7 #aiai2 ,hanzlik1 ,p4 ,j41 ,k>sn]1 ,h4 ,t41 & ,fett]man1 ,j41 ,anaphylactoid ,conditions1 ,j4 ,ph>macol4 & ,exp]4 ,!rap4 #ad3ahi 7,oct47 #aiai2 ,hanzlik1 ,p4 ,j41 ,k>sn]1 ,h4 ,t41 & ,fett]man1 ,f41 ,anaphylactoid ,ph5om5a f ,?rombopla/ic ,ag5ts1 ,j4 ,ph>macol4 & ,exp]4 ,!rap4 #ad3bbi 7,nov47 #aiai4 ,! prec$+ report 0 s5t to ! ,am]ican ag5t = ! ,society ( ,*emical ,indu/ry1 ,sept4 #h1 #aiai4 ,9 reply ! ,am]ican ag5t1 ,ciba ,co41 ,inc41 on ,m>* #bb1 #aibj1 s5t ! ,c\ncil 8"s additional cl9ical reports on ! use ( ,coagul5-,ciba 9 ! treatm5t ( ,hemorrhages support+ our claims ( ! m]its ( ,coagul5-,ciba40 ,! mat]ial submitt$ by ! ,ciba ,co41 conta9s no objective evid5ce = or aga9/ ! effici5cy ( ,coagul5-,ciba b m]ely op9ions4 ,z a rule ^! op9ions are favorable ?\gh conditional & h$g+ & q unconv9c+4 ,no?+ 0 submitt$ to (fset or *all5ge ! f9d+s ( ,dr4 ,hanzlik's report4 ,s9ce ! evid5ce indicates t ,coagul5-,ciba has little1 if any1 efficacy z a hemo/atic1 ! ,c\ncil direct$ its omission f ,new & ,non(ficial ,rem$ies4--7,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aibj1 p4 #ec47 ,,f]ric ,,cacodylate ,,omitt$ ,,f ,,new ,,& ,,non(ficial ,,rem$ies ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has au?oriz$ publication ( ! report :i* appe>s bel[1 expla9+ ! omission ( f]ric cacodylate f ,new & ,non(ficial ,rem$ies4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,iron cacodylate1 ! f]ric salt ( cacodylic acid1 0 admitt$ to ,new & ,non(ficial ,rem$ies 9 #aiag4 ,x is requir$ to conta9 f #ci4g to #dd4i p] c5t4 ( ars5ic 7,z74 ,! foll[+ /atem5t ( ! action1 uses & dosage ( iron cacodylate appe>s 9 ! #aibj edition ( ,new & ,non(ficial ,rem$ies3 8,actions & ,uses4--,f]ric ,cacodylate has ! prop]ties ( iron salts & ( ars5ic4 ,its use has be5 propos$ 9 conditions 9 :i* ! effects ( iron & ! mild ars5ic action ( cacodylates is desir$4 8,dosage4--f #j4jae to #j4a ,gm4 7#a_/d to #a-a_/b gra9s740 ,! p]iod = :i* ! iron cacodylate prep>ations n[ 9 ,new & ,non(ficial ,rem$ies 7 accept$ com+ to an end ) ! close ( #aibj1 ! ,c\ncil decid$ to det]m9e if suffici5t evid5ce = ! value ( f]ric cacodylate has accumulat$ to w>rant its cont9u$ recognition4 ,! foll[+ is ! report ( ! ref]ee ( ! ,committee on ,!rapeutics to :om ! matt] 0 assign$3 8,z f> z ! ,ref]ee kn[s1 ! only claim t ,iron ,cacodylate has z a !rapeutic ag5t is t x =ms a conv5i5t me?od = ! adm9i/ration ( ,iron & ,cacodylate 7:ile !re is no reason :y a drug %\ld n be giv5 by m\?1 usually intramuscul>ly1 & app>5tly x has rec5tly be5 giv5 intrav5\sly74 ,! effects to be expect$ f its use are ^? ( iron & ars5ic4 8,grant$ t iron & ars5ic are valuable !rapeutic ag5ts1 ,iron ,cacodylate is n a satisfactory prep>ation 9 :i* to adm9i/] ^! drugs = ! foll[+ reasons3 8#a4 ,x w\ld appe> t ,cacodylates are n ! be/ =m 9 :i* to adm9i/] ars5ic4 ,cacodylates 9 !rapeutic doses ex]t b a feeble action4 ,small quantities may be r$uc$ to cacodyl 7,,*7,z1 & v>y+ am\nts to inorganic ars5ic4 ,! am\nt trans=m$ to ars5ic is app>5tly unkn[n & probably v>ies 9 diff]5t individuals4 ,on ^! gr\nds alone ! use ( ! cacodylates :]e an ars5ic effect is desir$ seems dubi\s4 8#b4 ,! am\nts ( iron & cacodylates conta9$ 9 ! doses recomm5d$ are small :5 comp>$ ) ! usual doses ( ei!r iron or cacodylate4 ,! am\nt ( iron 9 ! ,iron ,cacodylate prep>ations is small1 ab\t 4#jjcf gram p] dose1 :ile ! prep>ations admitt$ to #8,useful ,drugs' conta9 mu* l>g] am\nts p] dose recomm5d$4 ,! li/ foll[s3 ,massa ,f]ri ,c>bonates ,fe p] dose 4#jdb gm4 ,pilulae ,f]ri ,c>bonates 4#jeh gm4 ,t9ctura ,f]ri ,*loride 4#jbb gm4 ,f]ri et ,ammonii ,citrae 4#jdb gm4 8,! approximate am\nt ( ars5ic 9 ,iron ,cacodylate 9 ! commonly recomm5d$ doses v>ies f 4#jab gm4 to #j4jbd gm41 :ile ! am\nt ( ars5ic 9 ,sodium ,cacodylate 9 ! recomm5d$ doses v>ies betwe5 4#jba & 4#ce gms4 ,x w\ld seem t a mu* m rational me?od ( adm9i/ration ( ^! two drugs w\ld be sep>ately1 9 :i* case a bett] control ov] ! dosage is possible4 8#c4 ,! ,ref]ee has be5 unable to secure reliable cl9ical evid5ce t ,iron ,cacodylate is a s]viceable prep>ation4 ,a se>* ( ! available lit]ature = ! pa/ fifte5 ye>s has be5 made1 also ,drs4 ,edsall1 ,longcope1 ,/5gel1 ,hoov]1 ,phillips & ,mill] h be5 consult$4 ,^! physicians "k no?+ ( its use4 8#d4 ,9 view ( ! above1 x appe>s to ! ,ref]ee t ,iron ,cacodylate is an irrational & useless me?od ( ! adm9i/ration ( iron & ars5ic40 ,! ,c\ncil adopt$ ! report ( ! ref]ee & direct$ t iron cacodylate be omitt$ f ! #aiba edition ( ,new & ,non(ficial ,rem$ies4--7,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aibj1 p4 #fb47 ,,libradol ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has au?oriz$ = publication ! foll[+ report :i* expla9s :y ,libradol 0 f\nd ineligible = ,new & ,non(ficial ,rem$ies4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,libradol is manufactur$ by ,lloyd ,bros41 ,c9c9nati4 ,accord+ to a circul> 7a 8readily removable0 label7 :i* accompanies ! trade package1 its 8uses0 are3 8,9 colds1 cr\p & acute bron*itis4 ,9 local conge/ions2 9 lung tr\ble1 9 acute inflammations ( ?is or any o!r organ1 especially if pa9 or sor5ess be pres5t4 ,9 lumbago1 sciatica1 or 9 rheumatic pa9s ( ! jo9ts or muscles4 ,appli$ to ! =ehead1 x induces sleep40 ,libradol is (f]$ 9 two =ms1 8,libradol ,mild0 = infants & sup]s5sitive p]sons :i* is said to be 8de/itute ( drug en]gy0 & ,libradol 8,regul>0 :i* is 8highly m$icat$10 ! 8con/itu5ts0 be+ 8,,dracontium1 ,,sangu9>ia1 ,,cephaelis1 ,,melaleuca1 ,,lobelia1 ,,laurus1 ,,capsicum1 ,,tobacco40 ,accord+ to a circul>1 8,! sanit>y plasma ,libradol0 is a 8homog5e\s1 highly m$icat$1 & exce$+ly pot5t comp\nd1 9 pla/ic =m10 :i* 8c>ries ! en]gies ( its drug con/itu5ts & ! high antiseptic qualities ( ,laurus ,camphora & ,melaleuca40 ,x is /at$3 8,! ,drug ,influ5ce ( ,libradol is necess>ily diff]5t f t ( any kn[n s+le memb] ( ! ,mat]ia ,m$ica4 ,b yet1 no my/]y ei!r 9 m$ic9e or ( ph>macy is claim$ z a "p ( its composition or process ( manufacture4 ,x is a ?+ peculi> to itself1 ! result ( ! /udy ( ! drugs f :i* x is d]iv$ & comp\nd$4 ,^! drugs may be /udi$ at leisure by :oev] c>es to d s44440 ,! foll[+ in=mation be>+ on ! composition ( ,libradol 0 furni%$ by ,lloyd ,bro!rs 9 response to a reque/ f ! ,c\ncil to aid 9 ! consid]ation ( ! prep>ation3 8#8,comp\nd ,lobelia ,p[d]' has be51 s9ce #aheb1 (ficial 9 ! ,am]ican ,disp5satory1 9 ! fir/ edition ( :i* 7#aheb7 its =mula is giv51 z foll[s3 8#8,take ( ,lobelia1 9 p[d]1 twelve ounces2 ,bloodroot & ,skunk ,cabbage1 9 p[d]1 ( ea*1 six ounces2 ,ipecacuanha1 eight ounces2 ,capsicus1 9 p[d]1 two ounces4 ,mix !m4' 8,?is prep>ation came increas+ly into dem& ) ! ,eclectic pr(ession1 ! pr9cipal use = :i* x 0 fir/ employ$ 7z an emetic71 be+ f9ally displac$ by its local application 9 bron*ial pneumonia tr\bles1 :5 spr9kl$ on a greas$ clo? & appli$ to ! *e/40 8,9 #ahih1 ,dr4 ,f9ley ,ell+wood petition$ ,lloyd ,bro!rs to make = him1 9 plasma =m1 ready = application1 a comp\nd c>ry+ ! +r$i5ts ( ! old #8,comp\nd ,lobelia ,p[d]1' /r5g!n$ by ! addition ( ,melaleuca leucad5dron1 ,laurus camphora & ,nicotiana tabacum4 ,exp]im5ts n v enc\rag+ 9 a ph>maceutical s5se 7 made1 & x 0 n until repeat$ reque/s _h be5 made t a product 0 at la/ satisfactorily prep>$ & =w>d$ to ,dr4 ,ell+wood 7#aijj71 ) no ?\ght o!r ?an t ( s]v+ him p]sonally 9 8 practice4 ,?is product he us$ & comm5d$ to 8 pr(essional fri5ds1 & "u 8 comm5dation x came into pr(essional dem&40 ,an exam9ation ( ! in=mation submitt$ by ,lloyd ,bro!rs %[$ ,libradol to be 9 conflict ) ! pr9ciples & rules t gov]n 9 ! acceptance ( articles = ,new & ,non(ficial ,rem$ies z foll[s3 ,composition 7,rule #a74--,! in=mation :i* has be5 receiv$ gives little idea ( ! actual composition ( ! prep>ation2 = example1 ! /atem5t t ,libradol 8c>ries ! en]gies ( its drug con/itu5ts & ! high antiseptic qualities ( ,laurus ,camphora & ,melaleuca0 gives no indication z to ! "p or p>ts ( ! ,laurus ,camphora or ,melaleuca employ$4 ,if ! /atem5t is correct1 t ,libradol 8is a homog5e\s1 highly m$icat$1 & exce$+ly pot5t comp\nd10 x is ess5tial t ! sev]al pot5t +r$i5ts be /at$ cle>ly & n m]ely h9t$ at by _! qualities4 ,o!r conflicts ) ,rule #a might be enum]at$1 b ! =ego+ citations /ate ! direct conflict2 & ?is has n be5 remov$1 al?\gh an inquiry 0 s5t to ,lloyd ,bro!rs = a /atem5t ( ! am\nt ( ea* pot5t +r$i5t 9 a giv5 quantity ( ,libradol4 ,indirect ,adv]tis+ 7,rule #d74--,! recomm5dation = ! use ( ,libradol 9 ! treatm5t ( colds1 bron*itis1 lumbago1 sciatica & rheumatic pa9s1 :i* accompanies ! trade package1 is prone to lead ! public to dep5d on x 9 cases :]e def9ite treatm5t is imp]ative4 ,unw>rant$ ,!rapeutic ,claims 7,rule #f74--,libradol is recomm5d$ 9 a great v>iety ( conditions & is especially claim$ n only to relieve pa91 b to remove ! cause ( pa94 ,?is is expla9$ z foll[s3 8,9 ! /udy ( ! physiological action ( _m drugs1 x 0 f\nd t ! con/itu5t rem$ies 9 ?is comb9ation ex]cis$ a mo/ salut>y influ5ce1 n only ^u ! s5sibility ( ! n]ves involv$1 b ^u ! capill>y circulation )9 ! diseas$ area1 ! muscul> /ructures !re9 includ$1 &1 subsequ5tly1 ^u ! c\rse ( ! advancem5t ( ! conge/ive & inflammatory processes1 & ^u secretion1 exudation1 adhesion1 induration1 hyp]trophy1 suppuration & excretion40 ,grant+1 = ! sake ( argum5t1 t c>efully controll$ exp]im5tal cl9ical evid5ce 7 available to sub/antiate ?is /atem5t ) ref]5ce to a s+le case ( pa91 ! /atem5t w\ld be mislead+ :5 consid]$ z a g5]al explanation ( ! prep>ation's reliev+ pa9 by remov+ ! cause ( pa9 :5 tak5 9 connection ) ! conditions = :i* x is recomm5d$ & 9 :i* pa9 is ev5 a m9or symptom4 ,/ill1 if pa9 7 reliev$ 9 ^! cases by remov+ ! cause1 ! pati5t w\ld be cur$ ( ! conditions :i* give rise to ! pa91 & ^! include3 8,acute pa9 9 ! *e/2444 acute inflammation 9 ! *e/2444 p]si/5t local pa924440 7,?is might be int]pret$ z includ+ tub]culosis2 pneumonia2 canc]1 & app5dicitis47 8lumbago2 sciatica2 articul> rheumatism0 7gonorrheal infections874 ,"n 7,rule #h74--,! "n1 d]iv$ f ,dol> & ,lib]1 sugge/s ! claim$ action ( ! prep>ation 7! relief ( pa97 r ?an ! drugs said to be pres5t$ by x4 ,irrational ,composition 7,rule #aj74--;,x is q possible t ,libradol w relieve pa9 9 c]ta9 in/ances & t ! drug con/itu5ts pres5t 9 ,libradol 8,regul>0 make ?is m effective ?an 8,libradol ,mild0 :i* is 8de/itute ( drug en]gy02 ?is1 h[ev]1 is no ju/ification = ! use by physicians ( a cataplasm conta9+ or made f skunk cabbage1 bloodroot1 ipecac1 melaleuca 7oil ( cajeput871 lobelia1 laurus comphora 7camphor871 capsicum & tobacco4 ,! comb9ation is ?or\ghly irrational & a rem9d] ( a pa/ c5tury4 ,fur!r1 ! ,c\ncil kn[s ( no evid5ce to support ! foll[+ claims3 8,z a /imulant ,capsicum has ! p[] ( neutraliz+ depressant rem$ies l ,lobelia & ,tobacco40 8,our association ( its desirable con/itu5ts ) ^? ( ,lobelia1 9 connection ) ! modify+ influ5ce ( ,capsicum1 ,melaleuca1 & ,laurus ,camphora1 p]mits a m free use 9 ,libradol ?an w\ld be possible 7 x to be employ$ alone40 8,capsicum1 ,melaleuca1 & ,laurus ,camphora 9 ,libradol t5d to c\nt]act ! excessive relaxative & depressant effects ( ,lobelia40 8,! great value ( ,melaleuca 9 ,libradol is its quality ( modify+ & controll+ ! action ( ! associat$ en]getic con/itu5ts ( ! drugs ,tobacco & ,lobelia1 :i* r$uce conge/ion & inflammation1 b :i* w\ld1 unsupport$1 be too depressant40 ,libradol is inadmissible to ,new & ,non(ficial ,rem$ies because its composition is complex1 irrational & semi-secret1 & because its "n & ! unw>rant$ !rapeutic recomm5dations made = x w lead to its ill-advis$ use4--7,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aibj1 p4 #fe47 ,,helmitol ,,omitt$ ,,f ,n4 ,n4 ,r4 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,helmitol is hexame?yl5am9 me?yl5citrate4 ,x 0 introduc$ ) ! claim t x 0 sup]ior to hexame?yl5am9--:i* acts 9 acid fluids only--9 t x is equally effici5t :e!r ! ur9e is alkal9e or acid4 ,9 #aiah ,! ,bay] ,company1 :i* !n m>ket$ ! product 9 ! ,unit$ ,/ates1 0 notifi$ t ! ,c\ncil que/ion$ ! claims made = ,helmitol & desir$ evid5ce to sub/antiate !m4 ,9 #aiai ! same notification 0 s5t ! ,w9?rop ,*emical ,company1 :i* 9 ! meantime _h secur$ control ( ! product4 ,p5d+ ! submission ( ! evid5ce1 ! ,c\ncil cont9u$ ! acceptance ( ,helmitol = ,new & ,non(ficial ,rem$ies ) ! /atem5t t ! actions & uses ( hexame?yl5am9 anhydrome?yl5citrate 7 ^? ( hexame?yl5am94 ,w4 ,a4 ,puckn]1 ,secret>y4 ,! foll[+ report on ,helmitol 0 made by ! ref]ee 9 *>ge ( hexame?yl5am9 comp\nds & prep>ations1 adopt$ by ! ,c\ncil & s5t ! ,w9?rop ,*emical ,company3 8,helmitol is a comp\nd ( anhydrome?yl5citric acid & hexame?yl5am94 ,x 0 introduc$ ) ! claim t x w\ld be antiseptic ev5 9 alkal9e ur9e4 ,! ,c\ncil did n entirely tru/ ! evid5ce1 b cont9u$ to li/ ,helmitol 9 ,n4 ,n4 ,r41 m]ely z a salt ( hexame?yl5am91 until satisfactory data %\ld become available4 ,^! h n[ be5 furni%$ by ,hanzlik 7,j\rnal ( ,urology #d3ade7 :o has %[n t3 8#a4 ,! alkal9ity requir$ to split (f =maldehyd f anhydrome?yl5citric acid is great] ?an exi/s 9 ! ur9e1 ev5 9 advanc$ ammoniacal f]m5tation4 8#b4 ,ev5 if any =maldehyd 7 lib]at$ 9 ammoniacal f]m5tation1 x w\ld at once become inactive by comb9+ ) ammonia4 8#c4 ,ur9e aft] ! adm9i/ration ( anhydrome?yl5citric acid actually putrefies readily4 8#d4 ,less ?an #e p] c5t4 ( ! anhydrome?yl5citric radical rea*es ! ur9e1 ! rema9d] be+ de/roy$ 9 ! body4 8,! only reason = ! exi/5ce ( ,helmitol 0 ?is claim ( antiseptic action 9 alkal9e & putrefy+ ur9es4 ,s9ce ?is has be5 disprov$1 !re rema9s no reason = reta9+ ,helmitol 9 ,n4 ,n4 ,r42 on ! contr>y1 its ret5tion w\ld only t5d to cont9ue ! fallacy on :i* x is bas$4 8,x is1 !re=e1 recomm5d$ t ,helmitol be no long] li/$ ) ,new & ,non(ficial ,rem$ies1 & t ?is report be publi%$1 aft] ! usual submission to ! manufactur]s40 ,9 accordance ) ! recomm5dation ( ! report1 ! ,c\ncil has direct$ ! omission ( ,helmitol f ,new & ,non(ficial ,rem$ies & has au?oriz$ ! publication ( ?is report4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #bb1 #aiba47 ,,spirocide ,,n ,,admitt$ ,,to ,n4 ,n4 ,r4 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has au?oriz$ publication ( ! foll[+ report4 ,w4 ,a4 ,puckn]1 ,secret>y4 8,spirocide0 7,! ,spirocide ,corporation ( ,new ,york7 is adv]tis$ z a new & successful treatm5t ( syphilis by fumigation & inhalation4 ,accord+ to ! in=mation pres5t$ to ! ,c\ncil1 ,spirocide is a me*anical mixture ( metallic m]cury #be p] c5t41 copp] sulphate #be p] c5t41 cypress cones #bj p] c5t41 h5na #bj p] c5t41 nut gall #e p] c5t41 & dri$ pomegranate #e p] c5t4 ,x is suppli$ 9 ! =m ( gre5i%-gray tablets weigh+ ab\t #aj gm4 ea*1 & conta9+1 !re=e1 ab\t #b4e gm4 7ab\t #ch gra9s7 ( m]cury4 ,x is sold 9 packages ( six tablets4 ,! foll[+ directions = its use are conta9$ 9 a pamphlet rec5tly di/ribut$3 8,spirocide is adm9i/]$ by means ( fumigation & inhalation4 ,! pati5t is disrob$ to ! wai/ & plac$ 9 a light *air1 pref]ably ) arms4 ,a pa/il or tablet ( ,spirocide is plac$ on a small plate1 or op5 receptacle1 aft] be+ ignit$ by hold+ 9 a gas or alcohol flame = a m9ute or s until x beg9s to sm\ld]4 ,! plate ) ! burn+ ,spirocide is !n plac$ on ! floor betwe5 ! pati5t's feet or j "u ! *air4 ,a small %elf or plat=m betwe5 ! l[] r\nds ( ! *air is an excell5t location = ! plate conta9+ ! burn+ mass4 ,:5 all is 9 position a %eet %\ld be ?r[n ov] ! pati5t & arrang$ to enclose ! :ole4 ,! pati5t %\ld brea! naturally & inhale ! vapor1 :i* w rise & fill ! canopy surr\nd+ him4 ,! treatm5t w require #ae to #cj m9utes1 or until ! ,spirocide is burn$ up4 ,! pati5t may compla9 at fir/ ( a slight *ok+ s5sation1 & !re may be "s t5d5cy to c\gh4 ,?is c be remov$ by rais+ ! %eet long en\gh to let 9 a little cle> air4 ,! eyes %\ld be clos$ or lightly b&ag$ to avoid sm>t+40 ,exp]im5ts conduct$ 9 ! ,a4 ,m4 ,a4 ,*emical ,laboratory %[ t ,spirocide1 :5 ignit$1 burns sl[ly ) consequ5t volatilization ( m]cury4 ,! sev]al organic con/itu5ts s]ve z fuel & ! copp] sulphate possibly acts z a regulator ( ! combu/ion4 ,dur+ ! burn+ process ! cypress cones1 h5na1 etc41 are consum$ b mo/1 if n all1 ! copp] rema9s beh9d1 ! m]cury only be+ vaporiz$4 ,x is ass]t$ 9 ! adv]tis+ pamphlet t ,spirocide is indicat$ 9 all /ages ( syphilis1 prim>y1 second>y & t]ti>y1 & 9 all its complications or sequelae4 ,9 ^! v>y+ conditions "o tablet daily or e o!r day is recomm5d$ until six treatm5ts h be5 tak51 ?\gh x is /at$ t 8occasionally1 dep5d+ on ! sev]ity or ! duration ( ! disease1 x may be wise to give n9e treatm5ts1 ! la/ ?ree at int]vals ( two1 ?ree or m days40 ,"s ( ! results :i* x is claim$ are obta9$ ) ,spirocide are3 8,at ! completion ( ?is c\rse ( treatm5t ) ,spirocide1 all signs or evid5ces ( syphilis are remov$1 & 9 t5 days to ?ree mon?s all ,wass]mann te/s prove negative4 ,any fur!r treatm5ts ?an ! orig9al c\rse ( fumigations are r>ely ne$$4 ,wass]mann's w be f\nd uni=mly negative aft] a p]iod :i*1 accord+ to ! pati5t1 may v>y f t5 days to ?ree mon?s4 ,^! results h be5 obta9$ 9 cases 9 :i* ,salv>san & k9dr$ prep>ations h be5 employ$ )\t ! slighte/ b5efit40 ,9 a lett] to ! ,c\ncil ! 8sci5tific obs]v]0 ( ! ,spirocide ,corporation decl>$3 8,we d n claim t ! vaporization me?od is new4 ,we d claim1 h[ev]1 t ?is comb9ation ( m]cury produces m rapid volatilization1 c]ta9 absorption & und\bt$ effect ?an any =m ( m]cury adm9i/]$ by any me?od kn[n to sci5ce )\t ! usual dang]4 ,t ?is is s we are will+ to prove by comp>ison ) o!r me?ods bo? by ourselves & _m obs]v]s scatt]$ ov] ! ,unit$ ,/ates44440 ,to det]m9e ! validity ( ! claims made = ,spirocide1 ! ,corporation 0 ask$ to pres5t ! evid5ce :i* x (f]$4 ,9 reply1 ! corporation's 8sci5tific obs]v]10 ,dr4 ,j4 ,lew5good1 submitt$ #hc case reports f a numb] ( diff]5t obs]v]s1 includ+ ^? f milit>y hospitals & a /ate in/itution1 & also a repr9t ( an article publi%$ by him 9 ! ,new ,york ,m$ical ,j\rnal1 ,feb4 #ba1 #aibj1 :]e9 7 report$ eight cases :i* receiv$ 8,spirocide ,treatm5t40 ,9 no case 7 controls ) o!r me?ods ( m]cury adm9i/ration c>ri$ out4 ,?is mat]ial ! ,c\ncil s5t to two recogniz$ syphilograph]s = an op9ion4 ,"o ( ! consultants report$ t ( ! #hc cases1 #bj dealt ) pati5ts :o _h also receiv$ arsph5am9 m$ication &1 !re=e1 ^! #bj cases c\ld n be consid]$ z evid5ce conc]n+ ! value ( ,spirocide4 ,z to ! rema9+ cases1 he f\nd on ! :ole t ! hi/ory & data furni%$ 7 f> f suffici5t to w>rant ! claims made4 ,9 _m ( ! cases emphasis 0 laid on ! ,wass]mann te/1 z ?\gh ?is te/ 7 ! only ?+ to be consid]$ 9 a case ( syphilis4 ,he po9t$ out t 9 "o case ! reaction *ang$ f negative to /rongly positive aft] six treatm5ts & t 9 sev]al cases ! ph5om5a report$ _c be expla9$ by any?+ else ?an a desire to get a negative blood te/4 ,= example1 "o case _h ,spirocide treatm5t & a ,wass]mann1 #a plus1 #ee days aft]2 ! au?or !n reports t #ai days lat] ! reaction _h become negative &1 !re=e1 ! *ange mu/ be due to ,spirocide4 ,9 sev]al ( ! cases report$ x is ev5 que/ionable if ! pati5ts 7 syphilitic4 ,! consultant conclud$ t ! evid5ce submitt$ by ! ,spirocide ,corporation fail$ to prove ! claims made = ,spirocide4 ,he po9t$ out on ! o!r h& t pati5ts readily become salivat$ f ! use ( ,spirocide1 (t5 aft] #h or #aj treatm5ts4 ,! second consultant repli$ t 9 8 op9ion ! claim t ,spirocide produces m 8und\bt$ effect ?an any =m ( m]cury adm9i/]$ by any me?od kn[n to sci5ce )\t ! usual dang]10 0 n sub/antiat$4 ,he believ$ t x 0 n z effective z "s o!r me?ods1 t ! dosage is n z exact1 &1 !re=e1 x is n z free f dang] :5 ! drug is pu%$4 ,! ,c\ncil's two consultants 7 also ask$ :e!r or n1 9 _! op9ion1 ! adm9i/ration ( m]cury by inhalation is a me?od :i* ! ,c\ncil %\ld endorse to ! ext5t ( recogniz+ a prep>ation bas$ on ?is pr9ciple4 ,?is inquiry 0 also s5t to ! memb]s ( ! editorial bo>d ( ! ,ar*ives ( ,d]matology & ,syphilology4 ,five replies 7 receiv$4 ,"o advis$ a ?or\gh /udy ( ! diff]5t me?ods ( adm9i/]+ m]cury by inhalation4 ,! o!r f\r 7 oppos$ to su* recognition on ! gr\nd t z ! dosage is n exact ! effects1 !re=e1 are n c]ta94 ,9 consid]ation ( ! op9ions express$ by its consultants1 ! ,c\ncil decl>$ ,spirocide inadmissible to ,new & ,non(ficial ,rem$ies because 7#a7 ! claims made = x are unprov$ & unw>rant$1 7#b7 ! r\t9e use ( an inexact me?od = ! adm9i/ration ( m]cury is detrim5tal to s\nd !rapy & 7#c7 ! "n is n descriptive ( its composition1 ?us fail+ to rem9d ! physician :o uses ^! pa/ils t he is adm9i/]+ metallic m]cury4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #bb1 #aiba47 ,,digifol9-,,ciba ,,n ,,admitt$ ,,to ,n4 ,n4 ,r4 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has au?oriz$ ! publication ( ! foll[+ report1 decl>+ ,digifol9-,ciba inadmissible to ,new & ,non(ficial ,rem$ies4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,digifol9-,ciba is a product ( ! ,society ( ,*emical ,indu/ry ( ,basle1 ,switz]l&4 ,x is m>ket$ 9 ! ,unit$ ,/ates by ! ,ciba ,company1 #ia ,b>clay ,/reet1 ,new ,york ,city4 ,x is claim$ t ,digifol9-,ciba is 8a prep>ation ( digitalis leaves t has be5 fre$ f ! useless & h>mful pr9ciples su* z ,digiton9 7sapon971 color+ & in]t matt]1 etc41 b does conta9 all ! really valuable1 !rapeutically active con/itu5ts ( ! leaves1 namely3 digitox9 & digitale9 9 _! natural proportions40 ,!re is no evid5ce t digifol9 conta9s all ( ! glucosides ( digitalis z !y exi/ 9 ! leaf1 & x is extremely improbable t ?is is ! case because "o _c remove sapon9 )\t alt]+ ! o!r active pr9ciples ( digitalis4 ,! ,ciba ,company s5ds out ! foll[+ pamphlets relat+ to ,digifol93 8#8,conc]n+ ,digifol9-,ciba1 ,a ,new ,prep>ation ( ,digitalis1' by ,c4 ,h>tung1 ,m4,d41 ,ph4,d4 ,extracts f ! "w #8,ueb] ,digifol91 ,e9 ,neues ,digitalis-,praep>at' 9 ! ,muni* ,m$ical ,weekly1 ,no4 #cf1 page #aidd1 #aiab40 8#8,digitox9 ,cont5ts ( ,digifol9-,ciba1' by ,c4 ,h>tung1 ,m4,d41 ,ph4,d41 ,basle1 ,switz]l&4 ,repr9ts f ! ,ph>maceutical ,po/1 #aiac4 ,no4 #cd1 page #ceg4 ,no4 #dj1 page #dca40 8#8,ph>macological ,te/s ( ,digitalis1' by ,m4 ,j4 ,*evali]1 ,*ef ,des ,travaux ,pratiques de ,ph>macologie et ,mati]e ,m$icale1 ,faculte ,de ,m$ec9e ,de ,p>is4 ,report ,pres5t$ to ! ,societe de ,!rapeutique at ,_! ,meet+1 ,may #bh1 #aiac40 ,9 ! repr9t 8,conc]n+ ,digifol91 #8,ciba4'0 ,h>tung lays /ress on ! pres5ce ( h>mful & in]t sub/ances pres5t 9 ! leaf & gal5ical prep>ations ) ! direct or impli$ /atem5t t digifol9 has an advantage 9 t ^! are abs5t f x4 ,?is is mislead+4 ,x is true t ,boehm :om ,h>tung cites1 f\nd sapon9 to be irritat+1 b ,boehm /ates t x requir$ #ajj mg4 p] kilogram ( body weight to induce vomit+ aft] its oral adm9i/ration4 ,fur!rmore1 sapon9 is pres5t 9 traces only 9 infusion ( digitalis1 s t ! !rapeutic dose conta9s a :olly negligible am\nt ( x4 ,! foll[+ occurs 9 8,ph>macological ,te/s ( ,digitalis10 by ,m4 ,j4 ,*evali]3 8,h>tung's ,digifol9 m]its our att5tion1 especially because x seems to possess all ! ph>macodynamic prop]ties ( gal5ic prep>ations ( digitalis )\t %[+ any ( _! disadvantages40 ,?is claim sc>cely ne$s comm5t1 s9ce x is well e/abli%$ t ! *ief 8disadvantages0 ( digitalis are inh]5t 9 ! pr9ciples :i* produce ! desir$ effects ( digitalis & may be avoid$ to a l>ge ext5t by a c>efully regulat$ dosage ( any digitalis prep>ation4 ,9 %ort1 ! adv]tis+ = ,digifol9 ass]ts t ?is digitalis prep>ation has all ! advantages ( digitalis itself1 b none ( its disadvantages4 ,?is claim has be5 refut$ s frequ5tly t manufactur]s mu/ be aw>e t x is unt5able4 ,fur!r ! claims n[ made = ,digifol9 are ess5tially ^? made ne>ly f\r ye>s ago at :i* "t ! att5tion ( ! ,am]ican ag5t 0 call$ to _! unw>rant$ "*4 ,! ,c\ncil decl>$ ,digifol9-,ciba inadmissible to ,new & ,non(ficial ,rem$ies because ! !rapeutic claims advanc$ = x are mislead+ & unw>rant$4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,april #b1 #aiba47 ,,"s ,,( ,,loes]',s ,,intrav5\s ,,solutions ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has au?oriz$ ! publication ( ! foll[+ report on 8,loes]'s ,intrav5\s ,solution ( ,hexame?yl5am910 8,loes]'s ,intrav5\s ,solution ( ,hexame?yl5am9 & ,sodium ,iodid10 8,loes]'s ,intrav5\s ,solution ( ,sodium ,salicylate10 8,loes]'s ,intrav5\s ,solution ( ,salicylate & ,iodid10 8,loes]'s ,intrav5\s ,solution ( ,sodium ,iodid0 & 8,loes]'s ,intrav5\s ,solution ( ,m]cury ,bi*lorid10 put out by ! ,new ,york ,intrav5\s ,laboratory1 ,inc4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,! intrav5\s solutions ( 8,hexame?yl5am910 8,hexame?yl5am9 & ,sodium ,iodid10 8,sodium ,salicylate10 8,sodium ,salicylate & ,sodium ,iodid10 8,sodium ,iodid0 & 8,m]curic ,*lorid0 m>ket$ by ! ,new ,york ,intrav5\s ,laboratory1 ,inc41 are solutions ( (ficial sub/ances sold "u _! (ficial names4 ,!y w\ld1 !re=e1 be outside ! scope ( ! ,c\ncil1 7 x n t special & g5]al !rapeutic claims are made = !m4 ,su* special claims1 = in/ance1 are conta9$ 9 an adv]tisem5t 9 ! ,ill9ois ,m$ical ,j\rnal = ,oct4 #bj1 #aibj1 :i* gives1 "u ! v>i\s drugs1 a li/ ( diseases 9 :i* ! drugs are said to be 8indicat$40 ,! ,c\ncil is unable to agree ) "s ( ^! recomm5dations4 ,! fundam5tal objection1 h[ev]1 is ! g5]al claim ( sup]iority & safety ( ! intrav5\s me?od4 ,! intrav5\s solutions nam$ above w\ld naturally h little sale if su* special claims 7 n made = !m4 ,:ile ! claims may n be made directly1 !y are c>ri$ by su* display phrases z 8,= ! progressive physician seek+ improv$ cl9ical results0 & 8,a safe practical (fice te*nique40 ,! ,c\ncil cont9ues to hold t intrav5\s m$ication1 g5]ally1 is n z safe z oral m$ication ev5 ) relatively h>mless sub/ances 7a fact aga9 illu/rat$ by ! results ( ,hanzlik & ,k>sn]1 #aibj1 ,j\rnal ,ph>macology & ,exp]im5tal ,!rapeutics1 #ad1 #cgi71 & t x does n give 8improv$ cl9ical results0 except "u r n>r[ly conf9$ circum/ances--namely1 if ! drug und]goes decomposition 9 ! alim5t>y tract1 if x is n absorb$1 if x causes s]i\s direct local reaction or if "t is an urg5t elem5t4 ,ea* intrav5\s prep>ation = :i* advantage ov] oral adm9i/ration is claim$1 directly or by implication1 mu/ be exam9$ f ^! po9ts ( view4 ,! ,c\ncil has recogniz$ intrav5\s prep>ations :i* satisfi$ ^! requirem5ts4 ,x is evid5t1 h[ev]1 t hexame?yl5am91 sodium iodid & sodium salicylate d n4 ,:5 giv5 orally !y d n und]go mat]ial decomposition 9 ! dige/ive tract1 !y are rapidly absorb$1 !y cause no direct local reaction1 & 9 ! conditions 9 :i* !y are us$ ! h\r or s :i* is requir$ = absorption is immat]ial1 especially z !y are us$ cont9u\sly = "s "t4 ,m]curic *lorid does inde$ produce "s local irritation1 b !re is z yet no conv9c+ evid5ce t its intrav5\s injection causes less injury ?an oral adm9i/ration4 ,m exp]i5ce "u controll$ conditions is ne$$ be=e ! intrav5\s use ( m]curic *lorid c be approv$4 ,especially objectionable are ! fix$ proportion mixtures ( sodium iodid ) sodium salicylate & ) hexame?yl5am94 ,! dosage ( all ?ree drugs has to be adapt$ to individual conditions4 ,?is is impossible :5 giv+ !m 9 fix$ proportions4 ,! ,c\ncil vot$ n to accept 8,loes]'s ,intrav5\s ,solution ( ,hexame?yl5am910 8,loes]'s ,intrav5\s ,solution ( ,hexame?yl5am9 & ,sodium ,iodid10 8,loes]'s ,intrav5\s ,solution ( ,sodium ,salicylate10 8,loes]'s ,intrav5\s ,solution ( ,salicylate & ,iodid10 8,loes]'s ,intrav5\s ,solution ,sodium ,iodid0 & 8,loes]'s ,intrav5\s ,solution ( ,m]cury ,bi*lorid0 = ,new & ,non(ficial ,rem$ies because !y are sold "u mislead+ claims reg>d+ _! alleg$ safety & effici5cy4 ,9 view ( ?is fundam5tal objection ! individual claims = ea* prep>ation 7 n pass$ on4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,april #af1 #aiba47 8,,national ,,iod9e ,,solution0 ,,n ,,admitt$ ,,to ,n4 ,n4 ,r4 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has au?oriz$ publication ( ! foll[+ report4 ,w4 ,a4 ,puckn]1 ,secret>y4 8,national ,iod9e ,solution0 is a propriet>y sold by ! ,national ,drug ,co41 ,philadelphia1 ,pa4 ,f inquiries receiv$ by ! ,c\ncil on ,ph>macy & ,*emi/ry x is evid5t t ! product is ext5sively br\ght to ! att5tion ( physicians by means ( circul>s4 ,! "n implies t x is a solution ( iod9 & ! inf]5ce is giv5 t x has ! advantages ( iod9 )\t ! disadvantages4 ,,composition ,9 view ( ! =ego+1 ! ,c\ncil took up ! inve/igation ( 8,national ,iod9e ,solution10 & 9 turn ask$ ! ,a4 ,m4 ,a4 ,*emical ,laboratory to analyze x4 ,! *emi/'s report foll[s3 ,accord+ to ! label ( ,national ,iod9e ,solution1 8ea* fluid\nce repres5ts ?ree gra9s ,proteo-album9oid comp\nd ( iod9 7,national702 also an alcohol decl>ation ( #g p] c5t4 is made4 ,o!rwise no in=mation is giv5 z to ! composition ei!r ( ! 8solution0 or ( 8,proteo-album9oid comp\nd ( ,iod9e40 ,ea* bottle conta9$ ab\t #aae c4c4 7ne>ly #d ounces7 ( a yell[i% solution1 acid 9 reaction1 hav+ an odor resembl+ wit* hazel2 its specific gravity at #be ,c4 0 #j4ihfj4 ,qualitative te/s indicat$ ! pres5ce ( z9c1 alcohol1 sulphate1 an iod9 comp\nd 7! solution gave te/s :i* indicat$ a v small am\nt ( free iod92 mo/ ( ! iod9 0 9 ! =m ( ord9>y iodid71 a small am\nt ( vegetable extractives1 & traces ( alum9um & potassium4 ,if any prote9 0 pres5t1 x 0 9 am\nts too small to be id5tifi$1 ?\gh a small am\nt ( a nitrog5\s comp\nd 0 pres5t4 ,! am\nt ( solids 9 8,national ,iod9e ,solution0 0 equival5t to #j4gb p] c5t1 & ! am\nt ( a%1 to #j4b p] c5t4 ,quantitative e/imations yield$ ! foll[+3 ,alcohol 7by volume7 #g4j p] c5t4 ,z9c 7,zn7 #j4jif p] c5t4 ,iod9 7free & comb9$7 #j4jbi p] c5t4 ,sulphate 7,,s--7 #j4adf p] c5t4 ,prote9 7,n #f4cf7 #j4jab p] c5t4 ,! above f9d+s indicate t ea* #ajj c4c4 conta9s ab\t #g c4c4 ( alcohol1 #j4e gram ( z9c sulphate ,u4 ,s4 ,p4 7,zn,s,o#g;,h,o471 #j4jc gram ( iod91 #j4ja gram ( prote9 7calculat$ z su* f nitrog5 times ! factor #f4cf7 & "s hamamelis wat]4 ,express$ 9 equival5t apo!c>y t]ms1 ea* fluid\nce conta9s ess5tially3 ,z9c sulphate #b-a_/c gra9s ,iod9 7free & comb9$7 #a_/h gra9 ,prote9 #a_/be gra9 ,alcohol #cd m9ims ,?is am\nt ( alcohol is equival5t to ab\t #c-a_/b fluidrams ( wit* hazel wat]4 ,al?\gh ! label /ates t ea* fluid\nce conta9s ?ree gra9s ( 8proteo-album9oid comp\nd ( iod9e10 yet ! sum ( ! prote9 7calculat$ f nitrog5 cont5t7 & iod9 compon5ts is equival5t to less ?an #a_/e gra94 8,national ,iod9e ,solution0 appe>s to be v simil> to 8,gonocol0 7,! ,national ,drug ,co41 ,philadelphia1 ,pa471 :i* 0 analyz$ by ! ,bureau ( ,*emi/ry ( ! ,u4 ,s4 ,dep>tm5t ( ,agriculture4 ,! bureau /at$ t 8x ,gonocol consi/$ ess5tially ( an aque\s solution ( z9c sulphate1 hamamelis wat]1 a small am\nt ( alcohol1 #j4ch gra9 ( iod91 & #j4cf gra9 ( prote9 p] fluid\nce40 ,x is evid5t t 8,national ,iod9e ,solution0 is n a solution ( free elem5t>y iod9 z ! "n sugge/s2 in/ead x appe>s to be a solution ( z9c sulphate 9 wit* hazel wat] conta9+ less ?an #j4jc p] c5t4 ( comb9$ iod9 & n m ?an a trace ( free iod94 8,national ,iod9e ,solution0 is "o m to be add$ to t already long li/ ( propriet>ies :i* makes capital ( ! high e/eem 9 :i* physicians hold iod94 ,,! ,,claims ,an adv]tis+ circul> s5t to physicians beg9s3 8,de> ,doctor3 ,we beg to sugge/ a l9e ( treatm5t :ile us+ ,national ,iod9e ,solution :i* our _m ye>s ( exp]i5ce has prov5 to u to give ! be/ & quicke/ results 9 ! treatm5t ( inflammation ( ! ure?ral tract 4440 ,9 x are giv5 directions = ! treatm5t ( 8acute gonorrhea1 male10 8ant]ior ure?ritis10 8ant]ior-po/]ior ure?ritis10 8ardor ur9 & *ordee10 etc41 by means ( ,national ,iod9e ,solution & o!r propriet>ies ( ! ,national ,drug ,company's make4 ,9 fact ! solution is claim$ to be 8,indicat$ 9 ,all ,conditions ( ,ure?ra ,accompani$ by a ,dis*>ge40 ,,comm5t ,,& ,,conclusions ,! !rapeutic claims made = 8,national ,iod9e ,solution0 are unw>rant$4 ,su* a solution is n indicat$ 9 all conditions ( ! ure?ra accompani$ by dis*>ge4 ,! advice conta9$ 9 ! circul> is equival5t to mail-ord] treatm5t ( gonorrhea4 ,x is ( int]e/ to note t ! claims = an id5tical or a simil> solution prep>$ by ! ,national ,drug ,company z a treatm5t = gonorrhea & int5d$ = use by ! laity1 has be5 adjudg$ misbr&$ by ! f$]al au?orities 7,notice ( ,judgm5t ,no4 #haej1 issu$ ,jan4 #be1 #aiba7 9 t x misl$ & deceiv$ ! pur*as] or pur*as]s !re( 9 ! /atem5ts reg>d+ ! !rapeutic or curative effects ( ! article1 :i* falsely & fraudul5tly repres5t x to be indicat$ 9 all conditions ( ! ure?ra accompani$ ) a dis*>ge1 8:]eas 9 tru? & 9 fact x 0 n40 ,! ,c\ncil w\ld emphasize t if physicians give he$ to adv]tis+ su* z t s5t out by ! ,national ,drug ,company = ?is prep>ation ! m$ical pr(ession _c ) good grace prote/ aga9/ ! r\t9e treatm5t ( v5]eal diseases by quacks & 8pat5t m$ic9e0 v5d]s4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,june #d1 #aiba47 ,,mon-,,arsone ,,n ,,admitt$ ,,to ,n4 ,n4 ,r4 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has au?oriz$ publication ( ! foll[+ report4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,mon-,arsone is (f]$ by ! ,h>m] ,laboratories ,company z 8a new & non-toxic ars5ical = ! treatm5t ( syphilis40 ,9 ! adv]tisem5ts = ,mon-,arsone x has be5 claim$ t ) ?is drug 8! toxic1 corrosive & unc]ta9 reactions att5d+ ! use ( arsph5am9e h be5 entirely elim9at$0 & t 8x has a !rapeutic value equal to arsph5am9e1 b ext5sive case reports fail to record ! slighte/ toxic reaction foll[+ its use40 ,accord+ to ! manufactur]s1 ,mons-,arsone is disodiume?yl>sonate1 ! sodium salt ( e?yl>sonic acid1 d]iv$ f ars5ic acid by replacem5t ( "o hydroxyl gr\p by ! e?yl gr\p--,as,o7,,*,,*77,,oh74 ,mons-,arsone is relat$ to sodium cacodylate1 :i* is ! sodium salt ( dime?yl-ars5ic acid--,as,o7,,*7,,oh--d]iv$ f ars5ic acid by replacem5t ( two hydroxyl gr\ps by two me?yl gr\ps4 ,e?yl>sonic acid & its potassium salt 7 describ$ by ,la ,co/e#aci m ?an ?irty-five ye>s ago1 & ! use ( ! sodium salt ( me?yl>sonic acid 0 propos$ 9 ,france "s ye>s ago4 ,! ,h>m] ,laboratories ,company claims orig9ality = ,mons-,arsone 9 t x 0 ! fir/ to prep>e ! sodium salt ( e?yl>sonic acid & to propose its !rapeutic use4 #aci ,la ,co/e3 ,annal5 d] ,*emie 7,liebig's7 #bjh3 #cd4 ,x 0 report$ sev]al ye>s ago by ,ca/elli#adj t sodium cacodylate & ! sodium salt ( me?yl ars5ic acid 7 devoid ( effect on exp]im5tal trypanosomiasis & spiro*ete infections4 ,c>eful cl9ical obs]vations 9 ?is c\ntry by ,h4 ,j4 ,ni*ols#ada & ,h4 ,n4 ,cole#adb h demon/rat$ ! inefficacy ( sodium cacodylate 9 ! treatm5t ( human syphilis4 #adj ,ca/elli1 ,g43 ,ar*4 f4 ,s*iffs- u4 ,trop5-,hyg4 #af3 #fje1 #aiab4 #ada ,ni*ols1 ,h4 ,j43 ,salv>san & ,sodium ,cacodylate1 ,j4 ,a4 ,m4 ,a4 #ef3 #dib 7,feb4 #ah7 #aiaa4 #adb ,cole1 ,h4 ,n43 ,a ,/udy ( ,sodium ,cacodylate 9 ! ,treatm5t ( ,syphilis1 ,j4 ,a4 ,m4 ,a4 #fg3 #bjab 7,dec4 #cj7 #aiaf4 ,animal exp]im5ts c>ri$ out 9 ! ,u4 ,s4 ,hygi5ic ,laboratory by ,voegtl9 & ,smi?#adc %[ t ,mon-,arsone is devoid ( any practical trypanocidal action4 ,?us ! 8!rapeutic ratio0 7! ratio ( ! m9imal effective dose to ! le?al dose7 0 ab\t #a1 t is1 x 0 effective !rapeutically only 9 approximately fatal doses2 ! !rapeutic ratio = arsph5am9e 9 simil> conditions 0 #ag1 & t ( neo>sph5am9e1 #bh4 #adc ,voegtl91 ,c>l1 & ,smi?1 ,h4 ,w43 ,j4 ,ph>macol4 & ,exp]4 ,!rap4 #af3 #ddi1 #aiba4 ,! f9d+s t sodium dime?yl>s5ate 7sodium cacodylate71 sodium me?yl>s5ate1 & sodium e?yl>s5ate are devoid ( any practical trypanocidal action & ! conclusion t sodium cacodylate is ineffici5t 9 ! treatm5t ( human syphilis does n prove t ,mon-,arsone is )\t effect on ! disease4 ,^! f9d+s1 h[ev]1 c]ta9ly dem& conv9c+ !rapeutic evid5ce to w>rant ! recomm5dation = ! use ( ! drug 9 ! treatm5t ( syphilis--p>ticul>ly because ! drug is propos$ z a sub/itute = arsph5am9e1 ! value ( :i* is e/abli%$4 ,:5 ! ,c\ncil fir/ took up ! consid]ation ( ,mon-,arsone1 ! only evid5ce = ! claim t x 8has a !rapeutic value at lea/ equal to t ( arsph5am9e0 consi/$1 ) "o exception1 ( reports f ^? :o _h exp]im5t$ ) ! drug = ! ,h>m] ,laboratories ,company1 includ+ a report by ,b4 ,l4 ,wright1 ,l4 ,a4 ,k5nell1 & ,l4 ,m4 ,hussey1#add ! latt] ( ! ,h>m] ,laboratories ,company4 ,^! reports appe>$ to %[ t ! adm9i/ration ( ,mon-,arsone caus$ less reaction ?an arsph5am9e1 & t ! imm$iate effects1 judg$ by cl9ical symptoms & ! response to ! ,wass]mann te/1 appe>$ to be good4 ,^! trials ext5d$ ov] too %ort a p]iod ( "t to p]mit judgm5t z to ! p]man5ce ( ! results4 ,a report by an indep5d5t obs]v] seem$ to indicate t ,mon-,arsone does n h ! /]iliz+ action on syphilitic lesions :i* x is usually believ$ arsph5am9e ex]cises4 #add ,wright1 ,b4 ,l42 ,k5nell1 ,l4 ,a41 & ,hussey1 ,l4 ,m43 ,m4 ,rec4 #ig3 #fjg 7,april #aj7 #aibj4 ,aft] exam9+ ! available evid5ce1 ! ,c\ncil advis$ ! ,h>m] ,laboratories ,company t ! claim t ,mon-,arsone has a !rapeutic value equal to arsph5am9e appe>$ unw>rant$2 t1 9 ! op9ion ( ! ,c\ncil1 ,mon-,arsone %\ld n be us$ except "u conditions t ju/ify ! exp]im5tal trial ( an unprov$ drug1 & %\ld n be us$ 9 a r\t9e way until ! p]man5ce ( its effects has be5 e/abli%$2 & consequ5tly any adv]tis+ propag&a = ! drug by ! ,h>m] ,laboratories ,company 0 to be deprecat$4 ,9 its reply ! ,h>m] ,laboratories ,company admitt$ t its adv]tis+ claim1 t ,mon-,arsone 0 at lea/ equal to arsph5am9e !rapeutically1 _h be5 bas$ on reports on fifty cases & on additional reports t 7 beg9n+ to come 9 at t "t4 ,! ,h>m] ,laboratories ,company submitt$ a li/ ( hospitals & physicians us+ ,mon-,arsone4 ,a lett] ( inquiry s5t by ! ,c\ncil to ^? :o1 accord+ to ! names 9 ! li/ suppli$ by ! ,h>m] ,laboratories ,company1 _h us$ ,mon-,arsone1 br\ght sev5 replies4 ,! cl9ical evid5ce conta9$ 9 ^! replies 0 to ! effect t ,mon-,arsone _h be5 us$ 9 ! v>i\s types ( syphilis & t !re 0 a c]ta9 b5eficial effect1 bo? cl9ically & z %[n by ! ,wass]mann reaction4 ,9 c]ta9 in/ances ! ,wass]mann reaction *ang$ f a f\r plus to a negative reaction4 ,! reports %[$ t ! effici5cy ( ,mon-,arsone z comp>$ ) t ( arsph5am9e prep>ations has n be5 adequately /udi$4 ,"o physician :o has us$ ,mon-,arsone ext5sively reports t 9 _m ( ! cases treat$ !re seem$ to be ne>ly z good results f ! use ( ,mon-,arsone z is frequ5tly obta9$ 9 ! use ( arsph5am9e4 ,he reports1 h[ev]1 t x 0 necess>y 9 elev5 out ( "o hundr$ cases to *ange f ,mon-,arsone to neo>sph5am9e4 ,9 view ( ! fact t !re is def9ite lack ( evid5ce to %[ t ,mon-,arsone is ! equal ( arsph5am9e !rapeutically1 & because ( ! reports t 9 "s cases x is inf]ior1 ,mon-,arsone %\ld n be us$ 9 ! treatm5t ( syphilis g5]ally until its !rapeutic /atus has be5 m rigidly inve/igat$ & conclusive evid5ce ( its sup]iority to arsph5am9e prep>ations obta9$4 ,! ,c\ncil vot$ n to admit ,mon-,arsone to ,new & ,non(ficial ,rem$ies & reaffirm$ its conclusion t ! claim t ,mon-,arsone has a !rapeutic value equal to t ( arsph5am9e is premature & unw>rant$2 t ,mon-,arsone %\ld n be us$ except "u conditions t ju/ify ! exp]im5tal trial ( an unprov$ drug2 & t ! adv]tis+ propag&a = ! drug by ! ,h>m] ,laboratories ,company is to be deprecat$4 99 99 99 99 99 ,:5 ! prec$+ report 0 s5t to ! ,h>m] ,laboratories ,company1 ! firm submitt$ a reply 9 :i* x 0 /at$3 #a4 ,t 9 c]ta9 in/ances pati5ts improv$ "u ,mon-,arsone :o1 previ\sly1 _h n improv$ "u arsph5am9e1 & t ?is %\ld be tak5 to (fset ! report ( ! "o hundr$ cases 9 :i* ! use ( ,mon-,arsone _h to be ab&on$ 9 #aa p] c5t4 ( ! cases4 #b4 ,t ! ,h>m] ,laboratories ,company has ab&on$ ! claim t ,mon-,arsone is !rapeutically equal to arsph5am9e & t x n[ furni%es ! drug to su* m5 z c>e to use x simply on ! basis ( its special & useful *>act]i/ics4 ,! ,c\ncil he>tily endorses ! rec5t w>n+ aga9/ ! use ( untri$ m$icam5ts :i* 0 issu$ by ! ,u4 ,s4 ,public ,heal? ,s]vice4#ade #ade ,j4 ,a4 ,m4 ,a4 ,june #ab1 #aibj1 p4 #afed4 ,s9ce ! ,c\ncil's report 0 prep>$ a report on ! effects ( ,mon-,arsone on exp]im5tal syphilis has be5 publi%$ by ,ni*ols1#adf f ! ,division ( ,laboratories1 ,army ,m$ical ,s*ool1 :i* concludes3 #a4 ,disodium-e?yl>s9ate1 or mon-arsone1 te/$ on rabbits infect$ ) syphilis %[s no spiro*eticidal p[]4 ,! tissues are fatally poison$ z soon z or be=e ! spiro*etes are affect$4 8#b4 ,= its practical use 9 syphilis !re is no su* g]micidal basis z exi/s 9 case ( ! arsph5am9e gr\p40--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,june #ah1 #aiba47 #adf ,ni*ols1 ,h4 ,j43 ,! ,spiro*eticidal ,value ( ,disodium ,e?yl ,ars5ate 7,mon-,arsone71 ,j4 ,a4 ,m4 ,a4 #gf3 #acce 7,may #ad7 #aiba4 ,,oxyl-,,iodide ,,n ,,admitt$ ,,to ,n4 ,n4 ,r4 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry 8,oxyl-,iodide0 7,eli ,lilly & ,co47 is said to be ! hydroiodid ( c9*oph5 & ! claim is made t x ex]ts ! effects ( c9*oph5 & ( iodid4 ,because ( inquiries :i* h be5 receiv$ ! ,c\ncil decid$ to det]m9e ! eligibility ( 8,oxyl-,iodide0 = ,new & ,non(ficial ,rem$ies4 ,dr4 ,p4 ,j4 ,hanzlik--=m]ly ,associate ,pr(essor ( ,ph>macology at ,we/]n ,res]ve ,univ]sity ,s*ool ( ,m$ic9e1 n[ ,pr(essor ( ,ph>macology at ,lel& ,/an=d ,junior ,univ]sity ,m$ical ,s*ool--:o has made a /udy ( ! action ( salicylates & c9*oph51 0 ask$ to report on ! !rapeutic value & ! rationality ( 8,oxyl-,iodide40 ,?is he cons5t$ to d & 8 report appe>s bel[4 ,aft] consid]+ ,doctor ,hanzlik's report1 ! ,c\ncil decl>$ 8,oxyl-,iodide0 inadmissible to ,new & ,non(ficial ,rem$ies because x is an irrational comb9ation1 m>ket$ "u claims t are unprov$ & consequ5tly unw>rant$4 ,w4 ,a4 ,puckn]1 ,secret>y4 8,oxyl-,iodide10 m>ket$ by ,eli ,lilly ,co41 is claim$ to be ! hydroiodid ( ph5ylc9*on9ic acid1 conta9+ #cc p] c5t4 ( iod9 & #fg p] c5t4 ( ph5ylc9*on9ic acid 7c9*oph574 ,its solubility resembles t ( c9*oph51 be+ l[ 9 wat] & acid m$iums1 & high] 9 ! pres5ce ( alkalis4 ,:e!r 8oxyl-iodide0 is decompos$ into its con/itu5ts 9 ! pres5ce ( alkalis does n appe> to h be5 det]m9$4 ,h[ev]1 if ?is 7 ! case1 ! inte/9e1 aft] adm9i/ration ( 8oxyl-iodide10 w\ld conta9 c9*oph5 & sodium iodid 9 ! same =ms z if ^! ag5ts 7 adm9i/]$ individually s t no?+ w\ld be ga9$ by adm9i/]+ 8oxyl-iodide40 ,be+1 l c9*oph51 practically insoluble 9 acid m$iums1 8oxyl-iodide0 w\ld h no advantage ov] ! latt] s f> z ga/ric irritation is conc]n$4 ,,dosage ,! dosage advis$ is f "o to ?ree tablets conta9+ #c gra9s 7#j4b gm47 ea* ( 8oxyl-iodide40 ,! total dosage w\ld dep5d on ! condition to be treat$4 ,9 rheumatic fev]1 :i* requires a full !rapeutic or s-call$1 8toxic0 dose ( c9*oph51 ab\t #ab to #ac gm4 w\ld be adm9i/]$ int5sively4 ,s9ce ea* tablet ( 8oxyl-iodide0 conta9s #j4ac gm4 ( c9*oph51 ! total numb] ( tablets ( 8oxyl-iodide0 requir$ w\ld be #ajj1 or two & "o-half bottles ( =ty tablets ea*4 ,at ! same "t ! pati5t w\ld receive #f4f gm4 ( iod9 7z iodid74 ,?is might be di/9ctly objectionable because ( ! production ( ! disagreeable symptoms ( iodism 9 "s p]sons1 & indicates t ! fix$ proportion ( ! iod9 con/itu5t w\ld be objectionable4 ,ev5 a small] dosage1 su* z #e gm4 ( c9*oph51 :i* gives p>tial relief 9 rheumatism & simil> conditions1 w\ld /ill require a pati5t to take a full bottle1 or =ty tablets1 ( 8oxyl-iodide10 & at ! same "t ab\t #b4g gm4 ( iod9 w\ld h to be +e/$4 ,fur!rmore1 rheumatic fev]1 ! ar?ritides1 g\t & relat$ conditions 9 :i* c9*oph5 is indicat$ d n require iodid4 ,!re=e1 8oxyl-iodide0 w\ld n be ! rem$y ( *oice 9 ^! conditions1 & its use w\ld be irrational & illogical4 ,,actions ,no data on ! ph>macologic actions ( 8oxyl-iodide0 are pres5t$ 9 ! manufactur]'s lit]ature4 ,presumably1 ! comp\nd w\ld exhibit ! actions ( its individual compon5ts1 i4 e41 c9*oph5 & iod9 7z iodid71 ?\gh probably less effici5tly1 ow+ to its l[ solubility4 ,?is is also indicat$ by ! foll[+ /atem5ts ( ! manufactur]3 8,! analgesic action ( #8oxyl-iodide' is gradual4 ,a ^w ( caution is necess>y to ^? :o may expect imm$iate relief f pa940 ,!re=e1 :y use 8oxyl-iodide0 9 place ( m dep5dable analgesics1 su* z salicylate or c9*oph54 ,! foll[+ /atem5ts appe> f>-fet*$3 8,!re is a /imulation ( ! endocr9es :i* is p]haps m m>k$ 9 ! ?yroid gl&1 al?\gh x is probably %>$ by ! pituit>y & o!r gl&s :i* function 9 a *a9-l control4444 ,!re is /imulation ( cells ) increas$ fl[ ( secretion1 visibly demon/rat$ by ! nasal muc\s membrane aft] #8oxyl-iodide' has be5 tak5 = "s "t4 ,! g5]al action on muc\s membranes favors elim9ation ( tox9s & wa/e products40 ,x is probable t 8oxyl-iodide0 acts z a uric acid elim9ant1 ?\gh !re is no reason to suppose t x is m effective ?an c9*oph5 alone4 ,no data are giv5 = ?is 9 ! manufactur]'s lit]ature4 ,,uses ,successful use ( 8oxyl-iodide0 is claim$ 9 bra*ial & sciatic neuritis1 lumbago1 muscul> rheumatism1 ar?ritis de=mans1 *ronic ar?ritis 78444 9 "s in/ances 7 app>5tly cur$071 subacute bron*itis1 circumflex neuritis1 traumatic or*itis1 eczema & rheumatism4 ,h[ev]1 a c>eful read+ ( ! protocols ( sev5 cases1 repres5t+ ^! conditions1 gives an unfavorable impression z to ! real contribution to ! recov]y by1 or value receiv$ f1 8oxyl-iodide40 ,summ>iz$1 ! op9ions z quot$ by ! manufactur]s 9 support ( _! claims = 8oxyl-iodide0 are briefly z foll[s3 ,case #a4 8,( c\rse1 ! case is n complete yet1 b ,i am look+ = cont9u$ bett]m5t40 ,case #b4 8,= two weeks pa/ h] improvem5t has be5 m>vel\s40 ,case #c4 8,! jo9ts are /ill enl>g$ & we d n hope to cle> !m entirely44440 ,case #d4 8,und\bt$ly1 removal ( ! kidney _h mu* to d ) improvem5t40 ,case #e4 8,i ?9k ,i h gott5 v good results40 ,case #f4 8,"s app>5t b5efit40 ,case #g4 8,%e is practically free f pa91 & ! muscle & jo9t /iffness is n[ slight40 ,^! inconclusive op9ions c]ta9ly d n agree ) ! favorable impression :i* o!r portions ( ! manufactur]'s lit]ature create4 ,if ! factor ( natural recov]y 9 ! conditions repres5t$ by ^! sev5 cases is giv5 due weight1 little1 if any?+1 is left to ! cr$it ( 8oxyl-iodide40 ,su* cl9ical evid5ce z is suppli$ by ! manufactur] indicates t ! !rapeutic effici5cy ( 8oxyl-iodide0 is d\btful1 & n an improvem5t ov] ei!r c9*oph5 or iodid4 ,,iodism ,iodism _c be avoid$ by ! use ( 8oxyl-iodide10 = ! manufactur]'s lit]ature /ates t 8! dosage ( #8oxyl-iodide' may be pu%$ to iodism z manife/$ by sk9 symptoms4444 ,to avoid iodism !re %\ld be an occasional int]ruption ( treatm5t40 8,oxyl-iodide10 !re=e1 has no advantage ov] ord9>y sodium iodid to avoid iodism4 ,usually1 ! conditions :i* require c9*oph5 d n require ! simultane\s adm9i/ration ( iodids1 & vice v]sa4 ,if adm9i/ration ( iodid & c9*oph5 toge!r %\ld be indicat$ or desirable1 ^! c be giv5 sep>ately ) ! add$ advantage t ! iodid c be easily r$uc$ or )drawn 9 case iodism sup]v5es1 & ! c9*oph5 c\ld be cont9u$ if necess>y4 ,s9ce conditions d n arise frequ5tly en\gh to w>rant ! use ( iodid & c9*oph5 toge!r1 ! exi/5ce ( su* a product z 8oxyl-iodide0 is unw>rant$4 ,f9ally1 ! manufactur] himself recognizes t ph5ylc9*on9ic acid 7c9*oph57 c take ! place ( 8oxyl-iodide40 ,"u 8dosage10 ! circul> /ates3 8,a few pati5ts may be idiosyncratic to ! iodides & f9d !y _c take #8oxyl-iodide4' ,= ! latt] *loroxyl1 ! hydro*loride ( ph5ylc9*on9ic acid1 is recomm5d$40 ,! action ( ! hydro*lorid ( ph5ylc9*on9ic acid does n diff]1 ( c\rse1 f t ( c9*oph54 ,! difficulties ( assign+ a cle>-cut1 def9ite1 !rapeutic rle to 8oxyl-iodide0 9 ord] to ju/ify its exi/5ce1 alongside well-kn[n & tri$ rem$ies are self-evid5t4 ,,conclusion 8,oxyl-iodide0 is ph>macologically & !rapeutically an illogical1 irrational & unju/ifi$ sub/itute = c9*oph5 & iodids4 ,! conditions :i* require ! adm9i/ration ( c9*oph5 d n z a rule require ! adm9i/ration ( iodid & vice v]sa4 ,if x is desirable to secure ! effects ( iodid & c9*oph5 toge!r1 ^! c be m conv5i5tly & advantage\sly adm9i/]$ z sep>ate ag5ts1 p]mitt+ 9 t way a bett] control ( _! actions4 ,?is _c be accompli%$ ) 8oxyl-iodide10 9 :i* ! proportion ( iodid & c9*oph5 are fix$4 ,symptoms ( iodism _c be avoid$ by ! adm9i/ration ( 8oxyl-iodide40 ,! objective evid5ces = its actions & uses are totally lack+2 & ! cl9ical op9ions conc]n+ its !rapeutic b5efits 9 diff]5t disease conditions are inconclusive & h$g+1 &1 if any?+1 contradictory to ! favorable impressions :i* ! language ( ! adv]tis+ matt] is likely to create4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,july #b1 #aiba47 ,,quassia ,,comp\nd ,,tablets ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has au?oriz$ publication ( ! foll[+ report1 decl>+ t ,quassia ,comp\nd ,tablets 7,fl9t1 ,eaton & ,company7 are inadmissible to ,new & ,non(ficial ,rem$ies4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,quassia ,comp\nd ,tablets1 m>ket$ by ,fl9t1 ,eaton & ,company1 ,decatur1 ,ill41 accord+ to ! label on a trade package submitt$ to ! ,c\ncil1 conta9 9 ea* tablet3 ,quassia #c_/d gra9 ,alo9 #a_/d gra9 ,*ionan?us #a gra9 ,ipecac #a_/af gra9 ,wahoo #c_/d gra9 ,podophyll9 #a_/d gra9 ,nux ,vomica #a_/b gra9 ,g+]9e q4 s4 ,casc>a #a_/c gra9 ,9 ! adv]tis+ ! 8,casc>a0 ( ! label is replac$ by ! indef9ite t]m 8,casc>90 & ! 8,g+]9e q4 s40 by 8,c>m9ative ,antigripe q4 s40 ,fl9t1 ,eaton & ,company in=m$ ! ,c\ncil t 8,c>m9ative ,antigripe is ,c4 ,p4 ,sodium ,sulphite ( :i* ea* tablet conta9s #a_/d gra940 ,! tablets 7 treat$ ) dilute hydro*loric acid & ! odor ( sulphur dioxid became app>5t4 ,?is %[s t ! company's /atem5t to ! ,c\ncil1 t ! tablets conta9 a sulphite1 is correct & ! =mula on ! label is incorrect4 ,9 ! adv]tis+ = ?is prep>ation we read3 8,a c>eful /udy ( ?is =mula :i* =mula8 ,t on ! label or t 9 ! g5]al adv]tis+8--,,c\ncil w reveal ! out/&+ fact t1 :ile !re are sev]al drugs employ$1 ea* +r$i5t is !re = a purpose & all d spl5did teamwork4 ,if y\r pati5t is con/ipat$ because ! /oma* is n suffici5tly en]getic1 ! ,quassia /imulates t organ to an increas$ secretion ( dige/ive fluids & sets x to work+ normally4 ,if ! liv] be sluggi%1 ! ,*ionan?us & ,wahoo prompt x to increas$ activity4 ,*ionan?us has no sup]ior = produc+ a su/a9$ heal?y hepatic condition4 ,%\ld ! b[els be sl[ & unc]ta91 ! small doses ( ,alo91 ,casc>9 & ,podophyll9 /imulate to free p]i/altic action1 :ile ! ,nux ,vomica sets ! n]v\s sy/em "r4 ,we use an effective ,antigripe s t !re is no grip+40 ,x is absurd to suppose t a complex mixture ( drugs 9 fix$ proportions c h ! actions claim$ = ,quassia ,comp\nd ,tablets4 ,z reg>ds ! claim t 8,*ionan?us has no sup]ior = produc+ a su/a9$ heal?y hepatic condition10 x 0 br\ght out 9 a report ( ! ,c\ncil on 8,"s ,unimportant ,drugs0 7,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiab1 p4 #cf7 t ! 8claims = ?is rem$y ,*ionan?us are n support$ by exp]im5tal evid5ce & ! cl9ical reports ( its use fail to %[ indications ( discrim9at+ critical obs]vation4 ,x is n notic$ by mo/ ph>macologic au?orities40 ,( ,wahoo 7,euonymus ,n4 ,f47 ! 8,epitome ( ! ,u4 ,s4 ,p4 & ,n4 ,f40 says3 8,actions & ,uses4--,obsolete ca?>tic2 toxic digitalis effects4 ,caption3 ! unc]ta9 absorption ( ?is drug makes its use inadvisable40 ,quassia ,comp\nd ,tablets 7,fl9t1 ,eaton & ,company7 are inadmissible to ,new & ,non(ficial ,rem$ies because 7#a7 !y conta9 drugs ( unprov$ value2 7#b7 _! composition is ne$lessly complex1 &1 !re=e irrational2 7#c7 unw>rant$ !rapeutic claims are made = !m2 7#d7 ! "n is mislead+ & n descriptive ( _! composition1 & 7#e7 ! /atem5t ( _! composition is indef9ite & incorrect4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,july #i1 #aiba47 ,,toxicide ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has au?oriz$ ! publication ( ! foll[+ report3 ,w4 ,a4 ,puckn]1 ,secret>y4 ,toxicide 7,toxicide ,laboratories1 ,*icago7 is alleg$ to be a rem$y :i* 8increases sy/emic resi/ance10 is 8us$ = immuniz+ aga9/ septic infections0 & 8is indicat$ 9 any case ( septic infection1 capable ( induc+ inflammation & pus =mation1 reg>dless ( location or k9d ( tissue involv$40 ,! foll[+ /atem5ts be>+ on ! composition ( ! prep>ation are furni%$ by ! manufactur]s3 8,toxicide conta9s ,la*esis #ab,x1 ,t>antula #f,x1 ,psor9um 7special7 #ae,x1 ,silicia #f,x & ,excipi5t q4 s4 7! excipi5t is sweet milk74 8,^! rem$ies are comb9$ 9 ! sweet milk & put ?r\gh a process ( developm5t1 :i* produces ! curative ag5t :i* we call #8,toxicide' 444 8,put up 9 tablet =m1 sug> coat$ & color$ r$40 ,no in=mation is giv5 z to ! proportions1 ei!r relative or actual1 ( ! +r$i5ts4 ,nei!r is any in=mation giv5 reg>d+ ! 8process ( developm5t0 to :i* ! mixture is subject$1 nor ! am\nt ( ! f9i%$ mixture :i* is conta9$ 9 ,toxicide tablets4 ,! ,toxicide ,laboratories pres5t ! foll[+ 8!ory03 8,9 comb9+ ^! rem$ies & process+ ) milk1 we develop a lat5t immuniz+ active pr9ciple1 :i* usually controls ! mo/ virul5tly1 active1 septic infections promptly40 ,illu/ration3 ,photographic reproduction 7r$uc$7 ( an adv]tisem5t ( ! 8orig9ator0 ( ,toxicide2 x ran = _m mon?s 9 ! program ( a burlesque !at] locat$ 9 ,ruckel's neighborhood4 ,!re is no evid5ce1 h[ev]1 t any ef=t has be5 made to demon/rate ! pres5ce ( a 8lat5t immuniz+ active pr9ciple0 by sci5tific me?ods ( mod]n immunology4 ,! foll[+ claims = ! use ( ,toxicide appe> on ! label3 8,acne1 boils1 c>buncles1 furuncles & abscesses ( ! mo/ virul5t types usually beg9 to %[ improvem5t )9 #d to #ab h\rs aft] beg9n+ adm9i/ration4 8,9 badly infect$ w\nds1 ,toxicide w *eck ! fur!r de/ruction ( live tissue & %\ld always be giv5 = a few days be=e & aft] op]ations on pus cases4 8,= gun%ot w\nds & o!r conditions difficult to /]ilize or dra91 ,toxicide is ! ideal rem$y4 8,= abscesses exi/+ or ?reat5$ 9 any obscure location1 ! middle e>1 ! ma/oid1 ! frontal or any accessory s9uses1 ,toxicide is ( ine/imable value4 8,if adm9i/]$ e>ly1 9 fractures1 comp\nd or simple1 or = lac]ation & o!r injuries1 inflammation1 swell+1 sor5ess & de/ruction ( tissue w be greatly mitigat$40 ,9 support ( ^! claims !re are (f]$ lett]s f physicians :o h us$ ,toxicide ) good results4 ,none ( ^! te/imonials pres5t evid5ce t ! report$ effects 7 due to ,toxicide4 ,! ass]t$--& highly improbable--action ( ,toxicide c\ld be det]m9$ only by an ext5sive s]ies ( c>efully controll$ cl9ical trials--& su* evid5ce is entirely lack+4 ,9 fact1 ! claims appe> to h no bett] basis ?an ! co9cid5ce :i* is /at$ to h l$ to ! discov]y ( ! 8rem$y02 namely1 t a boil on ! neck disappe>$ %ortly aft] ! adm9i/ration ( ,toxicide6 ,! ,c\ncil f9ds ,toxicide inadmissible to ,new & ,non(ficial ,rem$ies because 7#a7 ! id5tity & am\nt ( ! pot5t con/itu5t or con/itu5ts h n be5 furni%$2 7#b7 ! prep>ation is adv]tis$ indirectly to ! public2 7#c7 ! "n 8,toxicide0 is !rapeutically sugge/ive1 & 7#d7 ! !rapeutic claims1 be+ unsub/antiat$ by evid5ce1 are unw>rant$4 ,illu/ration3 ,photographic reproduction 7greatly r$uc$7 ( an adv]tis+ circul> us$ "s "t ago describ+ ! m>vels 7alleg$7 ( ,toxicide4 ,editorial ,comm5t4--,x seems r prepo/]\s t a sci5tific body1 su* z ! ,c\ncil on ,ph>macy & ,*emi/ry1 %\ld h to wa/e its "t 9 inve/igat+ & report+ on su* an obvi\sly unsci5tific product z 8,toxicide40 ,s long1 h[ev]1 z !re are physicians :o w take prep>ations ( ?is sort s]i\sly1 ! ,c\ncil feels t x is its duty to report on su* products4 ,! problem1 9 fact1 0 well /at$ 9 a lett] address$ to ! editor "s mon?s ago by ! secret>y ( a c\nty m$ical society :o _h j receiv$ a visit f a repres5tative ( ! ,toxicide ,laboratories & :o s5t to ,! ,j\rnal "s ( ! adv]tis+ matt] t he _h receiv$ f ! same s\rce4 ,?is physician wrote3 8,i d n wi% to tr\ble y ) ?is k9d ( mat]ial1 usually deposit$ safely 9 my wa/e pap] basket1 b ! enclos$ 0 h&$ to me today by a #8bird' :o is call+ on all ! doctors & mak+ /rong /atem5ts4 ,:5 he claim$ t #8,toxicide' is be+ us$ 9 ! ,presbyt]ian ,hospital1 ,*icago1 & t ! ,c\ncil on ,ph>macy & ,*emi/ry is consid]+ x s]i\sly1 etc41 etc41 ,i wi% to "k :e!r ,i am miss+ any real good ?+4 ,if x has any real virtue1 ,i w\ld l to "k ab\t x1 b if x has n1 x seems to me t some?+ ought to be done to head him (f z "s doctors are sure to fall = "s ( x40 ,! ,toxicide ,laboratories is1 app>5tly1 m]ely a trade "n us$ by ! alleg$ orig9ator ( 8,toxicide10 ,j4 ,f4 ,ruckel1 ,m4,d4 ,accord+ to our records1 ,ruckel 0 born 9 #ahfj & 0 graduat$ by ! ,*icago ,homeopa?ic ,m$ical ,college 9 #ahhf4 ,he claims to h orig9at$ ,toxicide ab\t tw5ty ye>s ago & to h prescrib$ x 89 ov] #c1jjj cases40 ,9 addition to ,toxicide1 ! ,toxicide ,laboratories also put out 8,dianasiac = ,nymphomania & ,satyriasis0 & 8,somnos9e = ,insomnia40--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,oct4 #h1 #aiba47 ,,pil4 ,,mix$ ,,treatm5t 7,,*i*e/]7 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has au?oriz$ publication ( ! foll[+ report3 ,w4 ,a4 ,puckn]1 ,secret>y4 8,pil4 ,mix$ ,treatm5t 7,*i*e/]70 is a propriet>y prep>ation ( ! ,hillside ,*emical ,co41 ,newburgh1 ,n4 ,y4 ,x is sold 9 ! =m ( pills1 ea* said to conta9 #a_/bj gra9 ( m]curic iodid & #e gra9s ( potassium iodid4 ,9 #aijg ! ,c\ncil exam9$ ! !rapeutic claims advanc$ = ?is prep>ation & f\nd t !y 7 unw>rant$1 exagg]at$ & mislead+4 ,x f\nd1 also1 _m mislead+ /atem5ts 9 reg>d to ! product itself4 ,fur!rmore1 ! ,a4 ,m4 ,a4 ,*emical ,laboratory f\nd ! pills to be 8%ort weight0 9 potassium iodid cont5t4 ,at ! "t t ! ,c\ncil exam9$ ,pil4 ,mix$ ,treatm5t 7,*i*e/]71 a d]matologi/ ( recogniz$ /&+1 to :om ! 8lit]ature0 = ?is product _h be5 submitt$ = an op9ion1 made ! foll[+ report3 8,assum+ t ?is pill conta9s :at is claim$ = x1 "o-tw5tie? 7#a_/bj7 ( a gra9 ( b9iodid ( m]cury & five 7#e7 gra9s ( potassium iodid1 x pres5ts nei!r an orig9al nor a v useful =mula4 8,! lit]ature furni%$ by ! company ab\nds 9 sugge/ions t ! mixture1 z !y prep>e x1 repres5ts "s unusual pot5cy :i* is n possess$ by ! ord9>y mixture ( ^! same drugs 9 ! same proportion4 ,^! sugge/ions may ( c\rse be dismiss$ )\t consid]ation4 ,!re is no?+ my/]i\s 9 a mixture ( potassium iodid & b9iodid ( m]cury & ?is =mula is no m entitl$ to special consid]ation ?an any o!r pill or tablet ( ! same composition prep>$ by any reputable ph>maceutical firm4 8,! =mula ( ?is pill1 h[ev]1 does n repres5t a good comb9ation4 ,x is (f]$ = use bo? dur+ ! active second>y p]iod ( syphilis & = t]ti>y lesions4 ,! pill does n conta9 en\gh m]cury to be an effici5t rem$y = second>y syphilis & n en\gh potassium iodid to be satisfactory 9 ! treatm5t ( t]ti>y lesions4 ,x is nei!r fi%1 fle%1 f[l1 nor good r$ h]r+4 ,a pati5t ) second>y syphilis %\ld n be dos$ all ! "t ) potassium iodid & = ! treatm5t ( t]ti>y lesions he %\ld h a v mu* l>g] quantity ( potassium iodid ?an c be giv5 9 ^! pills )\t giv+ toxic doses ( m]cury4 8,! /atem5t t ?is pill #8does n impair ! appetite nor di/urb dige/ion & is well borne by pati5ts :o _c tol]ate iodids o!rwise adm9i/]$' is a bald claim :i* _c be ju/ifi$ by exp]i5ce4 ,! mo/ unsatisfactory way ( adm9i/]+ potassium iodid is 9 solid =m4 ,a pati5t :o c /& potassium iodid 9 pill =m1 z x is furni%$ 9 ?is prep>ation1 c /& x 9 any =m 9 :i* x is ev] adm9i/]$4 8,9 %ort ?is prep>ation is nei!r agreeable nor effici5t4 ,! greate/ objection to x is its ineffici5cy1 = x is (f]$ z an adequate prep>ation = ! treatm5t ( syphilis 9 all ( its /ages1 :]eas x is nei!r satisfactory = ! treatm5t ( second>y syphilis nor ( t]ti>y lesions40 ,dur+ ! f\rte5 ye>s :i* h elaps$ s9ce ! ,c\ncil's fir/ exam9ation ( ,pil4 ,mix$ ,treatm5t 7,*i*e/]71 arsph5am9 has be5 add$ to ! syphilograph]'s armam5t>ium & mu* has be5 le>n$ ab\t syphilis & its treatm5t4 ,:ile !re exi/ diff]5ces ( op9ion z to ! exact value ( arsph5am9 9 ! treatm5t ( syphilis & !re are ev5 "s :o desi/ f ! use ( ars5ic comp\nds ( any k9d1 no syphilograph] ( /&+ c\nt5ances ! r\t9e treatm5t ( syphilis ) a fix$ comb9ation ( m]curic iodid & potassium iodid4 ,! use ( ,pil4 ,mix$ ,treatm5t 7,*i*e/]7 is on a p> ) ! use ( c]ta9 8blood purifi]s0 :i* 7 advocat$ at a "t :5 ! treatm5t ( syphilis 0 a baffl+ problem4 ,,pres5t ,,day ,,claims ,! pres5t adv]tis+1 :i* reads z if x _h be5 writt5 9 ! heyday ( propriet>y lic5se1 is1 9 effect1 an invitation to treat syphilis 9 its v>i\s /ages & manife/ations ) ,pil4 ,mix$ ,treatm5t 7,*i*e/]74 ,if he$$ by ^? :o read ! adv]tis+ ( ! ,hillside ,*emical ,co41 x w result 9 mu* h>m to ! public & ! pr(ession4 ,= ?is reason1 ! pres5t report ( ! ,c\ncil is publi%$ z a prote/ aga9/ any adv]tis+ propag&a advocat+ ! r\t9e treatm5t ( a disease :i* requires t ea* case be /udi$ c>efully s t prompt & effici5t measures may be appli$ to ! v>i\s manife/ations ( ! disease4 ,! foll[+ adv]tisem5t appe>$ rec5tly 9 sev]al m$ical j\rnals3 8,m$ic9e is an ,exact ,sci5ce--on ,pap] ,only60 ,e g5]al practition] ( m$ic9e is call$ ^u to treat ,syphilis occasionally4 ,he _c dep5d ^u ! use ( ars5icals alone4 ,9 mo/ cases1 8mix$ treatm5t0 ! giv+ ( m]cury & iodides is requir$ to get satisfactory results4 ,,pil4 ,,mix$ ,,treatm5t 7,,*i*e/]7 accurately & successfully meets ! indications & assures def9ite action4 ,important advantages3 ,ready solubility ( m]cury 9 comb9ation ) ,potassium ,iodide4 ,avoidance ( ga/ric1 buccal or inte/9al di/urbance4 ,easy adm9i/ration1 c be tak5 at any "t1 any:]e4 ,economical1 bo? drugs 9 "o comb9ation4 ,accurate adju/m5t ( dosage to ea* individual case4 ,full physiological action--assur$ by purity ( cont5t4 ,secrecy--pati5t or fri5ds d n "k nature ( m$ic9e4 ,pil ,mix$ ,treatm5t 7,*i*e/]7 has be5 "t te/$ & trial prov54 ,x ne$s no introduction to ! ?\s&s ( physicians :o prescribe or disp5se x4 ,:ile ! adv]tisem5t does n directly s advise1 yet x is a subtle invitation to ! g5]al practition] to use ,pil4 ,mix$ ,treatm5t 7,*i*e/]7 & ?us save himself & 8 pati5t ! "t & inconv5i5ce :i* ! rational treatm5t ( syphilis imposes4 ,a circul> 8,! ,treatm5t ( ,syphilis ,simplifi$ & ,improv$0 beg9s3 8,no !rapeutic fact is m conspicu\sly & decisively e/abli%$ ?an t a radical cure ( syphilis c be effect$ by ! cont9u\s adm9i/ration1 f ! p]iod ( developm5t1 ( a prop] comb9ation ( m]cury ) iod9e40 ,cont9u+1 x is admitt$ t m]cury is ! mo/ efficaci\s drug 9 ! prim>y & second>y /ages ( syphilis & iod9 9 ! t]ti>y /age1 b x is ass]t$ t3 8444 x is n[ grant$ by all syphilologi/s t ! antiluetic action ( ^! drugs is immeasurably augm5t$ by prop]ly comb9+ !m1 & t ! be/ results are obta9$ :5 !y are conjunctively adm9i/]$ ?r\gh\t ! entire c\rse ( ! disease40 ,argu+ along ! same l9es1 ?is circul> cont9ues3 8444 x 0 n until m]cury & iod9e 9 ! =m ( ,pil4 ,mix$ ,treatm5t 7,*i*e/]7 0 evolv$ t ! m>k$ advantages ( ! comb9$ employm5t ( ^! drugs 9 ! v>i\s /ages ( syphilis became a sci5tific c]ta9ty40 ,fur!r we are ask$ to believe t3 8,because ( ! greatly increas$ pot5cy ( m]cury & iod9e :5 comb9$1 z 9 ,pil4 ,mix$ ,treatm5t 7,*i*e/]71 ! =emo/ syphilologi/s are n[ agre$ t ! employm5t ( ^! drugs 9 su* =m %\ld be enjo9$ z soon z ! disease develops1 & %\ld be ?us cont9u$ until a cure has be5 effect$2 9 o!r words1 ,pil4 ,mix$ ,treatm5t 7,*i*e/]7 %\ld be made ! sole antisyphilitic m$ication ?r\gh\t all /ages ( ! disease40 ,! circul> illu/rates ! ext5t to :i* our k ( drugs may be di/ort$ & misrepres5t$ & ! public heal? jeop>diz$ 9 ! exploitation ( a propriet>y m$ic9e4 ,illu/ration3 ,"o reason sci5tific m$ic9e lags4 ,uncritical m$ical j\rnals p]petuate--= a price--! use ( no/rums4 ,,propriet>y ,,claims ,9 its adv]tis+1 ! ,hillside ,*emical ,co4 claims t ,pil4 ,mix$ ,treatm5t 7,*i*e/]7 bo? z to =mula & me?od ( prep>ation 89 ! incapsulat$ p[d] =m0 0 8br\ght to ! notice ( ! pr(ession by ,dr4 ,w4 ,r4 ,*i*e/] ( ,new ,york1 an em95t ,syphilograph] & recogniz$ au?ority 9 ! !rapeutics ( ,syphilis40 ,x is claim$ t ?is pill 8is p]fectly soluble1 ta/eless1 nonirritant1 & !re=e well adapt$ to a s5sitive /oma*40 ,x is claim$ t ! pill 8is always pref]able to "o extemporane\sly prep>$1 :i*1 ev5 if id5tical 9 composition1 (t5 gives negative results40 ,an exam9ation made 9 ! *emical laboratory ( ! association to det]m9e if ! product n[ m>ket$ conta9s ! claim$ am\nt ( potassium iodid indicat$ t ?is 0 ! case4 ,! *emi/ :o made ?is exam9ation comm5t$ z foll[s on ! claim t 9 ?is pill1 potassium iodid is r5d]$ ta/eless1 t ! pill is 8p]fectly soluble0 & t extemporane\s pills ( 8id5tical 444 composition (t5 give negative results40 8,t ! potassium iodid has be5 r5d]$ ta/eless is false1 naturally2 ! pills :5 plac$ 9 ! m\?1 aft] removal ( ! coat+1 h ! *>act]i/ic ta/e ( alkali iodids4 ,! claim t ! pills are entirely soluble is incorrect2 !y conta9 a l>ge am\nt ( insoluble mat]ial1 probably kaol94 ,! ass]tion t an extemporane\s comp\nd prescription ev5 if id5tical 9 composition ) ! ,*i*e/] pill is (t5 in]t1 is absurd & a repreh5sible attack by sugge/ion ( ! ideal t ! physician %all write 8 prescription to meet ! individual ne$s ( 8 pati5t & t ! ph>maci/ %all comp\nd ! prescriptions ( ! physician z !y are requir$4 ,x %\ld also be po9t$ out t :ile mu* is said ab\t ! potassium iodid 9 ! ,*i*e/] pill be+ 9 p[d]$ =m1 ! pill mass is solid & v sl[ly soluble & ! claim ( be+ 9 p[d]$ =m is1 if immat]ial1 also incorrect40 ,z to ! ass]t$ /&+ ( ! alleg$ discov]] ( ! =mula = ,pil4 ,mix$ ,treatm5t3 ,dr4 ,william ,r4 ,*i*e/] appe>s to h liv$ & practic$ 9 ,new ,york s9ce #ahhf or long]1 b ! claim t he is an 8em95t syphilograph]0 seems to h orig9at$ ) ! exploit]s ( 8,pil4 ,mix$ ,treatm5t40 ,se>* fail$ to %[ ! "n ( ,w4 ,r4 ,*i*e/] among au?ors ( textbooks ( syphilis or any o!r bran* ( m$ic9e or among au?ors ( contempor>y lit]ature 9 ! ,index ,m$icus f #aijg d[n to ! pres5t2 nor did a se>* ( ! catalogue to ! ,surgeon-,g5]al's ,libr>y reveal ,w4 ,r4 ,*i*e/] z ev] hav+ publi%$ any?+ on syphilis or any o!r subject4 ,pil4 ,mix$ ,treatm5t 7,*i*e/]7 is sold "u !rapeutic claims :i* are unw>rant$ & mislead+4 ,! prep>ation well illu/rates ! abuses :i* are connect$ ) ! exploitation z propriet>ies ( e/abli%$ drugs or mixtures ( e/abli%$ drugs4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,oct4 #bb1 #aiba47 ,,atophan ,,omitt$ ,,f ,n4 ,n4 ,r4 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has au?oriz$ publication ( ! foll[+ report expla9+ :y ,atophan has be5 omitt$ f ,new & ,non(ficial ,rem$ies4 ,s*]+ & ,glatz1 ,inc41 ! firm :i* m>kets ?is br& ( c9*oph5 9 ! ,unit$ ,/ates1 has refus$ to place ei!r ! ,u4 ,s4 ,ph>macopeial "n1 8,ph5ylc9*on9ic ,acid 7,acidum ,ph5ylc9*on9icum70 or ! ,n4 ,n4 ,r4 "n1 8,c9*oph510 on ! label & 9 ! adv]tis+ matt] s z to make ! id5tity ( ! product cle> to physicians4 ,fur!rmore1 ! product is sold "u !rapeutic claims :i* ! ,c\ncil holds to be exagg]at$ & unw>rant$4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,,comm]cial ,,hi/ory ,,( ,,c9*oph5 ,! sub/ance1 #b-ph5yl-qu9ol9-#d-;c>boxylic acid1 0 describ$ by ,doebn] & ,gieseke 9 #ahhg 7,ann4 d4 ,*em4 ,liebig's #bdb3bia74 ,! !rapeutic prop]ties ( ?is comp\nd 7 describ$ by ,nicolai] & ,dohrn 9 #aijh 7,deuts*4 ,ar*4 f4 kl94 ,m$4 #ic3cca74 ,subsequ5tly ! product 0 plac$ on ! m>ket & ext5sively adv]tis$ by ! ,*emis*e ,fabrik auf ,acti5 7vorm4 ,e4 ,s*]+71 ,b]l91 ,g]many4 ,?is firm also took out a pat5t 9 ! ,unit$ ,/ates on its production & 9 #aiaa secur$ a ,u4 ,s4 tradem>k on ! "n 8,atophan40 ,9 #aiab ,atophan 0 pass$ on by ! ,c\ncil & admitt$ to ,new & ,non(ficial ,rem$ies4 ,:5 ! gov]nm5t ( ! ,unit$ ,/ates took *>ge ( ,g]man-own$ pat5ts dur+ ! ,_w ,w>1 ! ,f$]al ,trade ,commission1 & lat] ! ,*emical ,f\ndation1 ,inc41 issu$ lic5ses to ,am]ican firms :]eby ^! 7 au?oriz$ to manufacture ! comp\nd4 ,9 ! meantime1 ,s*]+ & ,glatz1 ,inc41 :o _h be5 ! ,u4 ,s4 repres5tatives = ! ,*emis*e ,fabrik auf ,acti51 also und]took to supply ! drug1 b did n obta9 a lic5se f ! bo>ds 9 *>ge ( ,g]man pat5ts4 ,also1 ?is firm secur$1 9 #aiai1 a tradem>k ( ! ^w 8,atophan10 app>5tly aft] ! ,g]man-own$ tradem>k _h be5 cancel$4 ,! drug 8,atophan0 0 admitt$ to ! ,u4 ,s4 ,ph>macopeia z 8,ph5ylc9*on9ic ,acid 7,acidum ,ph5ylc9*on9icum740 ,z ?is "n prov$ too cumb]some1 ! ,c\ncil on ,ph>macy & ,*emi/ry co9$ ! abbreviat$ "n 8,c9*oph50 = x1 & ?is "n is n[ us$ by all ! firms :i* are m>ket+ ! product 9 ! ,unit$ ,/ates1 ) ! exception ( ,s*]+ & ,glatz1 ,inc41 :o use ! t]m 8,atophan10 fir/ own$ by ! ,*emis*e ,fabrik auf ,acti54 ,,atophan1 ,a ,,br& ,,( ,,c9*oph5 ,because ( ! confusion :i* is b\nd to arise f giv+ v>i\s names to "o drug1 ! ,c\ncil selects a common "n & provides /&>ds ( id5tity1 purity & /r5g? = any drug :i*1 by reason ( ! abs5ce or lapse ( pat5t rights or = o!r reason1 is op5 to manufacture by m ?an "o firm4 ,! ,c\ncil1 !n1 w accept su* article only if x is m>ket$ "u ! title adopt$ = ,new & ,non(ficial ,rem$ies4 ,! rules provide1 h[ev]1 t :5 ! ,c\ncil adopts a common "n = an article t has be5 admitt$ "u ano!r "n1 su* article w be reta9$ 9 ,new & ,non(ficial ,rem$ies "u ! old] "n if ! ,c\ncil "n is giv5 prom95ce on ! label & 9 ! circul>s & adv]tisem5ts1 9 ord] to avoid confusion4 ,accord+ly1 :5 ! p]iod ( acceptance = ,atophan 9 ,new & ,non(ficial ,rem$ies 0 ab\t to expire1 ,s*]+ & ,glatz 7 notifi$ t ,atophan c\ld be reta9$ 9 t publication only on condition t ! "n1 8,c9*oph510 or else ! ph>macopeial "n1 8,ph5ylc9*on9ic ,acid 7,acidum ,ph5ylc9*on9icum70 be plac$ on ! label & us$ 9 ! circul>s & adv]tis+4 ,,unw>rant$ ,,!rapeutic ,,claims ,,= ,,atophan ,at ! "t t ! ,c\ncil ask$ ,s*]+ & ,glatz to adopt c9*oph5 or ph5ylc9*on9ic acid z a synonym = ,atophan1 ! firm 0 also reque/$ to omit f future adv]tis+ a numb] ( !rapeutic claims to :i* ! ,c\ncil 0 oblig$ to take exception4 ,s*]+ & ,glatz refus$ ! fir/ reque/ & made no def9ite promise ) reg>d to ! second4 ,! ,c\ncil1 !re=e1 direct$ ! omission ( ,atophan f ,new & ,non(ficial ,rem$ies1 #aiba4 ,! adv]tis+ to :i* ! ,c\ncil took exception does n appe> to be di/ribut$ at pres5t4 ,a pamphlet has be5 s5t out1 h[ev]1 :i* is equally objectionable4 ,x conta9s unw>rant$ !rapeutic claims & sugge/s t ,atophan be us$ 9 conditions 9 :i* x is n indicat$4 ,= in/ance3 8,no long] ! vague1 hypo!tical1 #8te/-tube demon/rat$' pr9ciple ( uric acid elim9ation by solution1 b a def9ite1 sci5tifically & cl9ically e/abli%$1 physiologic /imulation ( ! uric acid excretion4 ,p]=m$ innocu\sly & controllable to a nicety by dosage & by ur9e & blood te/s40 ,! 8innocu\sness0 ( ,atophan has n be5 prov$2 on ! o!r h& !re is evid5ce t x is n innocu\s1 z ! rec5t inve/igations ( ,hanzlik & ,scott & _! collaborators 7,c9*oph51 ,neoc9*oph5 & ,novaspir9 9 ,rheumatic ,fev]1 ,j4 ,a4 ,m4 ,a4 #gf3 #agbh ,june #ah #aiba7 %[ t x may injure ! kidney4 ,! circul> also conta9s ! foll[+3 8,no long]1 hit & miss relief ( pa9 at ! exp5se ( ! he>t1 ! inte/9es1 ! kidneys & ! n]v\s sy/em1 b ! prompte/ & mo/ reliable analgesic1 anti-inflammatory & deconge/ive action s f> kn[n1 ) notable fre$om f he>t depressant1 r5al irritant1 con/ipat+ & cumulative toxic by-effects4 ,no contra9dications1 except *ronic nephritis & ! pres5ce ( kidney concretions40 ,?is is mislead+4 ,! drug depresses ! circulation1 injures ! kidney & produces symptoms ( salicylism or 8toxicity40 ,x is n ! prompte/ & mo/ reliable analgesic2 morph9 is sup]ior & salicylate is j z effici5t4 ,! phrase 8deconge/ive action0 is vague4 ,treatm5t ( pulmon>y conge/ion f phosg5e1 & conge/ion ( ! conjunctiva 9 mu/>d oil *emosis ( cats1 ) l>ge doses ( ,atophan 0 ineffective2 9 fact1 x prov$ di/9ctly h>mful4 ,?is 0 %[n by su* work]s z ,laqueur & ,magnus1 & ,heubn] & ,gildemei/] 7,zts*r4 f4 d4 ges4 exp]4 ,m$4 #ac3bjj1 #aiba74 ,x is incorrect to ascribe 8deconge/ive0 or 8anticonge/ive0 action 9 ! true s5se to ,atophan 7c9*oph574 ,! pr9cipal assets ( ! salicylate-c9*oph5 class ( drugs 9 ! treatm5t ( rheumatism & g\t are _! analgesic & antipyretic qualities4 ,! claim is made3 8,9 ,rheumatic & ,g\ty ,disord]s1 :e!r ( ! well-kn[n muscul> & ar?ritic type1 or _! ,eye1 ,e>1 ,nose & ,?roat manife/ations40 ,! sugge/ion t ,atophan is indicat$ 9 8_! ,eye1 ,e>1 ,nose & ,?roat manife/ations0 is a vague g5]alization )\t def9ite mean+1 b nev]!less calculat$ to impress physicians & promote ! sale ( ,atophan = common & m9or ailm5ts4 ,rh9itis & sore ?roat are1 ( c\rse1 self-limit$ conditions :i* require *iefly good habits1 p]sonal & g5]al hygi5e z prophylactic measures1 & simple hot ba?s ) re/1 in/ead ( m$ication1 = symptomatic relief4 ,:5 x comes to e> & eye conditions1 ,atophan c]ta9ly w\ld d no good 9 otitis m$ia1 panoph?almitis1 *oroiditis1 ret9itis1 etc4 ,! adm9i/ration ( ,atophan is propos$ 89 ,migra9s1 ,hemicrania1 ,eye/ra91 etc41 (t5 vaguely gr\p$ z #8,heada*es4'0 ,eye/ra9 & heada*es are vague symptoms (t5 aris+ f num]\s causes t require no m$ication1 b r good habits1 hygi5e & simil> corrective measures4 ,!re is always ! possibility ( habituation f ! use ( drugs = su* common & vague symptoms1 result+ ev5tually 9 m h>m ?an good to ! pati5t4 ,! use ( ,atophan is propos$ 8,9 ,influ5za 7,grippe7 = ! ready alleviation ( ! respiratory conge/ion1 pa9 & /iffness ( limbs & back40 ,probably ! entire claim is )\t w>rant1 s9ce influ5za is a self-limit$ disease4 ,atophan might relieve pa9 9 ! jo9ts1 r$uce ! fev]1 etc41 b at ! same "t x w\ld t5d to impair ! functional effici5cy ( ! he>t1 :i* may be impair$ already by ! disease4 ,c>diac failure is "o ( ! causes ( dea? 9 influ5za4 ,! recomm5dation = 8alleviat+ respiratory conge/ion0 is c]ta9ly )\t w>rant1 s9ce 9 actual trial 9 pulmon>y conge/ion by ,magnus et al41 ,atophan 0 f\nd to be delet]i\s & n b5eficial4 ,phosg5iz$ cats are probably z good a te/ object = ! alleg$ deconge/ive action ( ,atophan z any?+ c\ld be1 s9ce1 accord+ to ,und]hill & ,r+] 7,j4 ,a4 ,m4 ,a4 #ge3aeca1 #aibj7 ! pa?ological physiology ( ! circulation & respiration 9 phosg5e poison+ & influ5za are ne>ly id5tical4 ,fur!r1 ,atophan is recomm5d$ 8,9 ,pyorrhea ,alveol>is z a sy/emic support to local & specific measures40 ,atophan is n indicat$ "h4 ,pyorrhea requires local m$ication1 if any?+ at all4 ,x c\ld ex]t no local b5eficial effects 9 ?is condition2 inde$1 ! employm5t ( ,atophan might lead to irritation4 ,good d5tal treatm5t is m ess5tial ?an m$ication4 ,f9ally1 ,s*]+ & ,glatz advise ,atophan 8,9 ,eczema1 ,pruritus & simil> irritant & it*+ ,sk9 ,diseases ) l[]$ blood alkal9ity40 ,! assumption t blood alkal9ity is l[]$ 9 irritant & it*+ disease is unsupport$ by evid5ce 9 m$ical lit]ature & ! recomm5dation is incorrect & mislead+4 ,nei!r does ,atophan alt] ! reaction ( ! blood4 ,amelioration 9 ^! caprici\s conditions occurs )\t m$ication s t any relief t might be obta9$ c\ld n be attribut$ to ,atophan4 ,! entire p>agraph is mislead+ & w und\bt$ly t5d to ext5d ! use ( ,atophan 9 conditions = :i* x is n suit$4--7,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiba1 p4 #h47 ,,urotrop9 ,,omitt$ ,,f ,n4 ,n4 ,r4 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,urotrop9 is a propriet>y "n appli$ to ! sub/ance :i* is kn[n 9 *emical lit]ature z hexame?yl5etetram9 & :i* is designat$ hexame?yl5am9e 9 ! ,u4 ,s4 ,ph>macopeia4 ,! ,c\ncil has au?oriz$ publication ( ! foll[+ report expla9+ t ,urotrop9 0 omitt$ f ,new & ,non(ficial ,rem$ies because ,s*]+ ,glatz1 ,inc4 7! firm t m>kets ?is br& ( hexame?yl5am9 9 ! ,unit$ ,/ates71 refus$ to place ! ,u4 ,s4 ,ph>macopeia "n ,hexame?yl5am9e 7hexame?yl5am9a7 on ! label & 9 its adv]tis+ s z to make cle> to physicians ! id5tity ( ! product1 &1 fur!rmore1 because x 0 sold "u !rapeutic claims :i* ! ,c\ncil held unw>rant$4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,comm]cial ,hi/ory ( ,hexame?yl5am9 ,?is sub/ance :i* is g5]ally ref]r$ to 9 *emical lit]ature z hexame?yl5etetram91 ! cyclic cond5sation product ( =maldehyd & ammonia1 appe>s to h be5 describ$ fir/ 9 #ahfj 7,butl][3 ,ann4 d4 ,*em4 #aae3cbb1 #ahfj74 ,subsequ5tly1 num]\s ref]5ces to ! prep>ation1 prop]ties & con/itution ( ! sub/ance appe>$ 9 *emical lit]ature4 ,hexame?yl5etetram9 is said to h be5 fir/ us$ = !rapeutic purposes by ,g4 ,b>det1 :o1 9 #ahid1 report$ to ! ,socit de ,?rapeutique t he believ$ ?is sub/ance to be a uric acid solv5t4 ,at ab\t ! same p]iod1 ,a4 ,nicolai]1 :o gave ,b>det cr$it = sugge/+ ! use ( hexame?yl5etetram9 z a uric acid solv5t1 ann\nc$ ! discov]y ( its antiseptic action 7,c5tralbl4 f4 d4 m$4 ,wiss5s*4 #cb3hig1 #ahid2 ,deuts*e m$4 ,w*ns*r4 #ba3eda1 #ahie74 ,%ortly !reaft] z a result ( ,nicolai]'s publication1 ! ,*emis*e ,fabrik auf ,akti5 vorm4 ,e4 ,s*]+1 ,b]l91 ,g]many1 began to (f] ! product to ! m$ical pr(ession "u ! tradem>k$ & nondescriptive "n 8,urotrop9e40 ,9 ! ,unit$ ,/ates1 x 0 m>ket$ by ,s*]+ & ,glatz1 :o !n 7 act+ z ,am]ican ag5ts = ! ,s*]+ works ( ,g]many4 ,x soon became evid5t t hexame?yl5etetram9 0 a valuable drug4 ,z ! sub/ance 0 introduc$ at a "t :5 new 8syn!tic0 drugs 7 rapidly appe>+ & :5 unlimit$ & uncritical confid5ce 0 plac$ 9 !m1 & be=e ! m$ical pr(ession became skeptical ( ! claims advanc$ by manufactur]s = _! respective 8discov]ies10 x 0 n long be=e ?is new drug 0 plac$ on ! m>ket by _m firms1 ea* apply+ its own "n & (t5 keep+ ! *emical "* ( x 9 ! backgr\nd4 ,"s ( ! names :i* 7 ?us appli$ to hexame?yl5am9 7 ,cy/og51 ,am9(orm1 ,=m91 ,uritone1 ,urisol1 & ,cy/am9e4 ,9 #aijg ! late ,pr(4 ,j4 ,o4 ,s*lott]beck1 !n a memb] ( ! ,c\ncil1 prote/$ aga9/ ! confusion caus$ by ! m>ket+ ( a giv5 drug "u diff]5t names4 ,he /at$ t x 0 n uncommon = a physician to prescribe two or m ( ^! id5tical sub/ances 9 ! same mixture1 expect+ to get ! comb9$ action ( diff]5t ur9>y antiseptics2 also1 t pati5ts _h be5 treat$ fir/ ) hexame?yl5am9 "u "o "n & lat] by ! same sub/ance "u ano!r "n 7,! ,j\rnal1 ,jan4 #ai1 #aijg1 p4 #bda74 ,hexame?yl5etetram9 0 admitt$ to ! eigh? revision ( ! ,u4 ,s4 ,ph>macopeia4 ,9 "p because ( ?is (ficial recognition & /&>dization & 9 "p because ! extravagant reports ( its virtues _h be5 l>gely disc\nt$1 physicians h 9 g5]al prescrib$ ! drug by its ph>macopeial "n1 ) "o notable exception3 ,urotrop94 ,"o reason = ?is is t ,urotrop9 0 ! fir/ propriet>y br& ( hexame?yl5etetram9 introduc$1 a second reason is t ?r\gh ! ext5sive & p]si/5t adv]tis+ ( ! propriet>y "n "u :i* ! sub/ance 0 introduc$1 x has become firmly fix$ 9 ! m9ds ( _m physicians4 ,! o!r is t ! product 0 claim$ to be ( great] purity ?an ! product sold "u ! ph>macopeial or o!r "n al?\gh no evid5ce confirmatory ( ?is claim has ev] be5 publi%$4 ,on ! o!r h&1 ,daniel ,base1 z long ago z #aijg1 f\nd t hexame?yl5am9 sold "u its ph>macopeial "n is j z pure z :5 sold "u propriet>y names4 ,:51 9 #aijg1 urotrop9 0 admitt$ to ,new & ,non(ficial ,rem$ies1 ! publi%$ description %[$ t x 0 manufactur$ by ! ,*emis*e ,fabrik auf ,akti5 vorm4 ,e4 ,s*]+1 ,b]l91 & t ,s*]+ & ,glatz 7 ! ,unit$ ,/ates ag5ts4 ,9 #aiai1 ! description 0 revis$ to %[ t ,s*]+ & ,glatz 7 no long] sell+ ! ,g]man product4 ,z x is ! g5]al practice to omit articles t are admitt$ to ! ,u4 ,s4 ,ph>macopeia = ! reason t _! quality is gu>ante$ "u ! f$]al ,food & ,drugs ,act & because ph>macopeial nonpropriet>y articles are r>ely adv]tis$ ) claims t require ! ,c\ncil's control1 yet1 9 ! case ( ,urotrop91 x 0 reta9$ because x 0 sold "u a "n n recogniz$ 9 ! ph>macopeia & because special 7propriet>y7 claims 7 made = x4 ,urotrop9 ,m>ket$ ,"u ,unw>rant$ ,!rapeutic ,claims ,! p]iod = :i* ,urotrop9 /ood 8,accept$0 expir$ ) ! close ( #aiba4 ,to det]m9e its cont9u$ eligibility = ,new & ,non(ficial ,rem$ies1 ! ,c\ncil exam9$ ! labels & circul> matt] s5t by ,s*]+ & ,glatz = ! purpose & also a booklet 8,urotrop910 subsequ5tly s5t by ! firm to physicians4 ,x 0 f\nd t ! pamphlet conta9$ a numb] ( unw>rant$ /atem5ts4 ,p>ticul>ly objectionable are ! claims made = ! use ( ,urotrop9 z an antiseptic 9 body fluids t are alkal9e1 su* z ! c]ebrosp9al fluid1 bile1 aque\s humor ( ! eye1 saliva1 ! excretions caus$ by middle e> infection & o!r excretions ( ! nasal1 bron*ial1 l>yngeal & muc\s membranes4 ,! lack ( efficacy ( hexame?yl5am9 9 alkal9e secretions is g5]ally admitt$ & ! cl9ical ref]5ces to ! use ( hexame?yl5am9 9 ! pamphlet are obsolete4 ,9 ! introduction to ! pamphlet1 ,s*]+ & ,glatz /ate t !y are well acqua9t$ ) ! sci5tific rese>* "w discr$it+ ! effici5cy ( hexame?yl5am9 9 nonacid m$iums1 b t !y feel t ! accumulat$ evid5ce = its efficacy 9 su* conditions %\ld n be 8bru%$ aside40 ,h[ev]1 ! pamphlet is n made up ( quotations1 b ( unqualifi$ /atem5ts4 ,) "o exception1 all ref]5ces to ! antiseptic prop]ties ( ! drug 9 alkal9e m$iums are previ\s to #aiac1 t is1 be=e ! importance ( reaction ( ! m$ium 0 fully appreciat$4 ,to quote ^! e>li] articles )\t reg>d to ! lat] "w1 :i* 9 mo/ eyes discr$it$ !m1 con/itutes 9 effect an exploitation ( ?is br& ( hexame?yl5am9 "u unw>rant$ !rapeutic claims4 ,urotrop9 a ,br& ( ,hexame?yl5am9e1 ,u4 ,s4 ,p4 ,9 consid]ation ( ! confusion :i* arises f ! application ( diff]5t names to an id5tical article1 ! rules ( ! ,c\ncil provide t :5 an article :i* has be5 accept$ = ,new & ,non(ficial ,rem$ies is admitt$ to ! ,u4 ,s4 ,ph>macopeia "u ano!r "n1 x w be reta9$1 provid$ ! (ficial "n is giv5 prom95ce on ! label & 9 ! adv]tis+ ( su* article4 ,nei!r ! label nor ! adv]tis+ = ,urotrop9 gives prom95ce to ! ph>macopeial "n z a synonym nor inde$ does x br+ out ! fact t ,urotrop9 is a br& ( hexame?yl5am9e1 ,u4 ,s4 ,p4 ,s*]+ & ,glatz1 ,inc41 0 advis$ t ,urotrop9 c\ld be reta9$ 9 ,new & ,non(ficial ,rem$ies only on condition t ! objections to ! !rapeutic recomm5dations 7 remov$ & on agreem5t t ! ,u4 ,s4 ,p4 "n appe> on ! labels & circul> matt]4 ,! firm did n (f] to make ! product eligible = cont9u$ recognition2 accord+ly ! ,c\ncil direct$ ! omission ( ,urotrop9 because ( conflict ) ,rule #f 7,unw>rant$ ,!rapeutic ,claims7 & ) ,rule #h 7,objectionable ,names74--7,f ,reports ( ,c\ncil on ,ph>macy & ,*emi/ry1 #aiba1 p #ga47 ,,/yptysate ,,n ,,admitt$ ,,to ,n4 ,n4 ,r4 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has au?oriz$ publication ( ! foll[+ report1 decl>+ ,/yptysate 7,ern/ ,his*(f ,co41 ,inc47 inadmissible to ,new & ,non(ficial ,rem$ies4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,/yptysate1 accord+ to ! adv]tisem5t ( ,ern/ ,bis*(f ,co41 ,inc41 ,new ,york1 is 8obta9$ by dialysis f ,bursa ,pa/oris 7,%epp>d's sic6 ,purse740 ,x is claim$ to be 8,! ,rem$y ,= ,hemorrhages10 to be 8,sup]ior to ,ergot & ,hydra/is10 8( p>ticul> advantage 9 ,m5orrhagia & ,metrorrhagia0 & to h be5 8f\nd ( great value 9 vesical hemorrhages & hemorrhages f muc\s membranes 9 g5]al40 ,! ,/yptysate label be>s ! synonym 8,dialysate ,h]ba ,bursa ,pa/oris02 ! /atem5t t x conta9s 8alcohol #aa p] c5t40 & t x is 8made 9 ,g]many40 ,no o!r /atem5t ( ! composition or /r5g? ( 8,/yptysate0 is furni%$ nor is ! "n ( ! ,g]man manufactur] disclos$4 ,9 an adv]tis+ circul> entitl$ 8,/yptysate1 a ,new ,reliable ,hemo/atic10 x is decl>$ t 9 rec5t ye>s ! plant1 ,%eph]d's ,purse 7,capsella bursa pa/oris71 8has be5 submitt$ to cl9ical te/s 9 ! =m ( a conc5trat$ dialysate1 kn[n z ,/yptysate1 by ,loewy1 ,opp5heim1 ,krumma*] & o!rs1 & t _! reports co9cide 9 reg>d to ,/yptysate z a hemo/atic p> excell5ce1 p>ticul>ly 9 ut]9e hemorrhages1 ev5 9 cases :]e ergot & hydra/is _h fail$ to produce satisfactory results40 ,! circul> also repr9ts "s 8%ort cl9ical reports0 )\t ref]5ce to _! au?or%ip2 "o ascrib$ to ,krumma*] & two ascrib$ to 8,b4,h4,m41 ,kansas ,city1 ,mo410 & ! foll[+ ref]5ces3 8,a4 ,krumma*]1 ,m4,d41 ,mon?ly ,review = ,ob/etrics & ,gynecology1 ,b]l91 ,vol4 ,,xlix1 #d1 & ,vol4 ,,lii40 8,h4 ,opp5heim1 ,m4,d41 ,m$ical ,cl9ic1 ,b]l91 #aibj1 #ce40 ,%eph]d's ,purse is a we$ common 9 ! ,unit$ ,/ates & 9 ,europe4 ,l mo/ o!r h]bs1 x has "s reputation z a folk m$ic9e4 ,x is us$ by eclectics & homeopa?s1 be+ includ$ 9 ! ,homeopa?ic ,ph>macopeia ( ! ,unit$ ,/ates4 ,%eph]d's ,purse receives no consid]ation at ! h&s ( ! au?ors ( /&>d works on mat]ia m$ica1 ph>macology or !rapeutics4 ,f an exam9ation ( rec5t ,g]man m$ical publications1 x appe>s t ! use ( ,%eph]d's ,purse 0 propos$ z a sub/itute = ergot & hydra/is1 :5 ! latt] drugs became sc>ce 9 ,g]many4 ,^! publications1 9 ! ma91 emanate f ^? 9 ! employ ( ph>maceutical firms & deal ) propriet>y prep>ations or !y are writt5 by physicians :o us$ ^! propriet>y prep>ations at ! solicitation ( ! manufactur]s4 ,= ?is reason ! report$ results mu/ be accept$ ) res]ve4 ,"o ( ! propriet>y prep>ations discuss$ 9 ! ,g]man publications is ,/yptysate1 manufactur$ by ,isalfabrik ,johannes ,bu]g]1 ,w]nig]ode4 ,x is said to be produc$ by submitt+ ! juice ( fre% ,%eph]d's ,purse to dialysis & pres]v+ ! dialysate by ! addition ( alcohol4 ,!re is no /atem5t z to ! drug /r5g? or ! *emical or biological /&>ds1 if any1 us$ 9 its manufacture2 h5ce1 ! prep>ation is ess5tially a secret "o4 ,z fir/ produc$1 ! prep>ation seems to h be5 =tifi$ by ! addition ( cot>n93 ! dose 0 !n giv5 z t5 to fifte5 drops4 ,lat]1 z ! co/ ( cot>n9 w5t up1 ?is drug 0 omitt$1 & ! drug /r5g? increas$2 ! dose ( ! new prep>ation is giv5 z tw5ty-five to ?irty drops4 ,j :at relation1 if any1 ! ,/yptysate ( ,ern/ ,bis*(f ,co41 ,inc41 be>s to t ( ! ,isalfabrik ,johannes ,bu]g]1 ,w]nig]ode1 _c be det]m9$ f ! ,bis*(f adv]tis+4 ,if x has any relation%ip ! ann\ncem5t t no n>cotic ord] is requir$ :5 ord]+ ,/yptysate w\ld indicate t ! new prep>ation is suppli$2 ! old "o ) its addition ( cot>n9 w\ld require a n>cotic ord]4 ,on ! o!r h&1 ! recomm5d$ dose ( ! cot>n9-free prep>ation is tw5ty-five to ?irty-drops1 :]eas ! product sold by ,bis*(f & ,co4 is to be giv5 9 doses ( t5 to fifte5 drops--t is1 9 ! am\nt propos$ = ! cot>n9-=tifi$ product4 ,:at ju/ification is !re = ! claim t ,/yptysate has be5 submitt$ to cl9ical te/s by ,loewy1 ,opp5heim & ,krumma*] & f\nd to be a hemo/atic p> excell5ce & effici5t ev5 :]e ergot _h fail$ to give satisfactory results8 ,loewy 7,z5tralblatt fr ,gyncologie #db3ibj1 #aiba7 made "s ph>macologic te/s on gu9ea-pigs ) ! cot>n9-conta9+ prep>ation1 b report$ no cl9ical trials4 ,hans ,opp5heim 7,m$iz9is*e ,kl9ik1 ,aug4 #bi1 #aibj1 p4 #ijf7 report$ t he 0 agreeably surpris$ at ! excell5t results 7vorzuegli*em ,erfolg7 obta9$ ) ! drug b he did n ass]t t x is sup]ior to ergot4 ,krumma*] report$ on ?irte5 cases ( pr(use m5/ruation 9 :i* ! pati5ts 7 treat$ ) ,/yptysate1 us+ = a "p1 ! prep>ation conta9+ cot>n9 & = ! o!r a prep>ation )\t cot>n94 ,he report$ z good results ) ! cot>n9-free prep>ation 9 l>g] dosage1 z ) ! cot>n9-conta9+ prep>ation 9 small] dosage4 ,krumma*] did n comp>e ,/yptysate ) ergot4 ,"s ( ,krumma*]'s cases are quot$1 ) "s typographical errors1 9 ! ,bis*(f circul>4 ,on ! assumption t ! product discuss$ 9 ,g]man publications is ! ,/yptysate m>ket$ 9 ! ,unit$ ,/ates1 ! be/ t c be said = x is1 t dur+ a %ortage ( ergot x 0 us$ 9 place ( t e/abli%$ drug4 ,!re is no evid5ce to w>rant ! use ( ?is indef9ite propriet>y 9 place ( ! biologically /&>diz$ fluidextract ( ergot or o!r /&>diz$ ergot prep>ations4 ,/yptysate 7,ern/ ,bis*(f & ,co41 ,inc47 is inadmissible to ,new & ,non(ficial ,rem$ies because its composition is semisecret & indef9ite & !re is no evid5ce t its uni=mity & /r5g? is controll$ 7,rules #a & #b72 fur!r1 x is inadmissible because ! !rapeutic claims advanc$ = x are exagg]at$ & unw>rant$ 7,rule #f7 & because !re is no evid5ce t x possesses any advantage ov] e/abli%$ drugs su* z ! biologically /&>diz$ fluidextract ( ergot or ! def9ite ergot prep>ations admitt$ to ,new & ,non(ficial ,rem$ies4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,feb4 #aa1 #aibb47 ,,lipoidal ,,sub/ances 7,,horovitz7 ,,n ,,admitt$ ,,to ,n4 ,n4 ,r4 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has au?oriz$ publication ( ! foll[+ report decl>+ ,lipoidal ,sub/ances 7,horovitz7 inadmissible to ,new & ,non(ficial ,rem$ies because its composition is ess5tially secret & because ! curative claims made = x are unsub/antiat$ &1 !re=e1 unw>rant$4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,9 ! adv]tis+ ( ! ,horovitz ,bio*emic ,laboratories ,co4 7,a4 ,s4 ,horovitz1 presid5t7 we read3 8,horovitz proves by c>eful p>allel$ inve/igations ( normal & ( pa?ological tissues1 bo? 9 addiction disease & 9 o!r diseases1 t 9 pati5ts suff]+ f n>cotic addiction disease !re is an inactivity ( ! lymph-gl&s due to ! use ( ! drug & t ! sy/em is n suppli$ ) ! necess>y fats40 8,horovitz fur!r f\nd t ! lipoidal cont5t ( ! c]ebro-sp9al sy/em v>ies 9 /rict accordance ) ! pa?ological processes introduc$ by infection or by alkaloids4 ,fur!rmore1 he has f\nd t ! lipoids ( v>i\s o!r organs1 z well z ^? ( ! ,t,h,e,r,m,o,rnervous sy/em1 may be extract$ & consum$ by ! adm9i/ration ( n>cotic alkaloids40 ,x is fur!r /at$ 9 ! adv]tis+ t3 8,aft] a long & v c>eful rese>* inve/igation1 ,dr4 ,horovitz work$ out a me?od ( rational treatm5t = n>cotic addiction disease :i* involves ! re/oration ( ! lipoids1 :i* h be5 lo/ ?r\gh ! action ( ! drug1 & ( ! tox9s1 by means ( a comb9ation ( lipoidal sub/ance f v>i\s plant lipoids 9 ! =m ( a /]ile solution4 ,?is prep>ation n only replaces ! lipoids lo/ by ! tissues1 b also protects ! n]ve tissues1 f attacks by ! tox9s elaborat$ dur+ ! use ( n>cotics1 &1 ?is by detoxicat+ ! tissues1 br+s ab\t p]man5t fre$om f ! crav+ ( n>cotics1 in/ead ( ! tempor>y relief af=d$ by o!r me?ods ( treatm5t40 ,! 8comb9ation ( lipoidal sub/ance ( v>i\s plant lipoids0 :i* 0 work$ out by ,horovitz1 ! ,horovitz ,bio*emic ,laboratories (f] z 8,lipoidal ,sub/ances40 ,?is prep>ation is suppli$ 9 amp\les said to conta9 #a c4c4 ( solution4 ,! treatm5t ) 8,lipoidal ,sub/ances0 consi/s1 fir/1 9 ! complete )drawal ( ! n>cotic2 second1 9 free ca?>sis2 & ?ird1 9 ! intramuscul> injection ( ! prep>ation4 ,! initial dose is giv5 z #h to #ab m9ims repeat$ ) increase ( #c to #d m9ims e ?ree h\rs dur+ ! fir/ day4 ,on ! second1 ?ird & f\r? day #af m9ims is to be giv5 twice a day & 8f ! fif? day until ! m$ication is /opp$ 7usually #bh to #ce days7 x w be necess>y usually to give b #a injection ( #af m9ims ea* day40 ,9 a reque/ = ! admission ( its prep>ation to ,new & ,non(ficial ,rem$ies1 ! ,horovitz ,bio*emic ,laboratories ,co4 /at$3 8,! composition ( ,lipoidal ,sub/ance is 7a7 ,lipoids ( plant orig91 7b7 ,vitam9es 7wat] soluble7 ( plant orig91 7c7 ,non-specific plant prote9s1 7d7 ,pres]vatives--,none40 ,:ile ! communication ab\nd$ 9 g5]alities1 x gave nei!r ! id5tity nor "* ( ! lipoids1 ( ! vitam9s nor ( ! nonspecific prote91 nor _! quantities or me?ods = _! control4 ,! firm pres5t$ no evid5ce t ! injection ( 8,lipoidal ,sub/ances0 produc$ any effect o!r ?an by sugge/ion4 ,also1 :ile a long li/ ( ref]5ces to publications be>+ on lipoids 0 submitt$ 7_m ( :i* _h no be>+ on ! subject "u consid]ation7 !re 0 no ref]5ce to ! "w ( ,horovitz quot$ 9 ! firm's adv]tis+4 ,aft] exam9+ ! in=mation :i* _h be5 submitt$1 ! ,c\ncil reque/$ ! manufactur] to supply3 #a4 ,in=mation z to ! "* 7id5tity7 ( ! sev]al +r$i5ts conta9$ 9 ! prep>ation t x m>ket$1 ! am\nt ( ea* +r$i5t s f> z kn[n & ! me?od us$ = _! control4 #b4 ,evid5ce t ! adm9i/ration ( 8,lipoidal ,sub/ances0 is ( value 9 ! treatm5t ( drug addiction4 #c4 ,evid5ce = ! claims t ! 8rese>*es0 ( ,horovitz h prov$ t 89 pati5ts suff]+ f n>cotic addiction disease !re is an inactivity ( ! lymph-gl&s 444 & ! sy/em is n suppli$ ) ! necess>y fats0 & t 8lipoidal cont5t ( ! c]ebro-sp9al sy/em v>ies 9 /rict accordance ) ! pa?ological processes introduc$ by infection or by alkaloids0 & t 8! lipoids ( v>i\s o!r organs z well z ^? ( ! n]v\s sy/em1 may be extract$ & consum$ by ! adm9i/ration ( n>cotic alkaloids40 ,! ,horovitz ,bio*emic ,laboratories repli$ t ! reque/$ in=mation w\ld be suppli$ 9 ab\t two weeks4 ,at ! expiration ( ?ree mon?s ! promis$ in=mation & evid5ce _h n be5 receiv$2 nei!r _h any reports to %[ ! value ( ! treatm5t come to ! att5tion ( ! ,c\ncil4 ,! ,c\ncil1 accord+ly1 decl>$ 8,lipoidal ,sub/ances0 7,horovitz ,bio*emic ,laboratories7 inadmissible to ,new & ,non(ficial ,rem$ies because ! composition is ess5tially secret & because ! curative claims are unsub/antiat$ & unw>rant$4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,feb4 #be1 #aibb47 ,,yea/ ,,prep>ations ,,& ,,vitam9 ,b ,,conc5trates ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has adopt$ ! foll[+ pr9ciples z a guide 9 ! consid]ation ( yea/ prep>ations & vitam9 ,b conc5trates = ,new & ,non(ficial ,rem$ies4 ,w4 ,a4 ,puckn]1 ,secret>y4 #a4 ,! claim t defici5cy ( vitam9 ,b & diseases result+ !refrom are common conditions 9 ! ,unit$ ,/ates is n at ?is "t support$ by adequate acceptable evid5ce4 #b4 ,! claim t yea/ prep>ations or extracts are1 9 pr9ciple or 9 g5]al1 ess5tially m effective or m practical or m available means ( adm9i/]+ vitam9s ?an ! commonly available vitam9-conta9+ foods is n at ?is "t support$ by adequate acceptable evid5ce4 7,any claims = sup]iority made = su* products propos$ = inclusion 9 ,new & ,non(ficial ,rem$ies mu/ be pres5t$ 9 detail & pass$ on specially by ! ,c\ncil47 #c4 ,! claim t !rapy ) yea/ or yea/ prep>ations has z yet m ?an an exp]im5tal /atus is n at ?is "t support$ by adequate acceptable evid5ce4 ,prep>ations = :i* su* claims are made1 directly or by implication or 9 "o-sid$ quotations1 9 adv]tisem5ts or lett]s or by salesm51 _c be admitt$ to or reta9$ 9 ,new & ,non(ficial ,rem$ies4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,april #ae1 #aibb47 ,,"p ,,ii ,,contributions ,,f ,,! ,a4 ,m4 ,a4 ,,*emical ,,laboratory ,,=eword ,,! ,,*emical ,,laboratory ,,( ,,! ,,am]ican ,,m$ical ,,association ,! ,*emical ,laboratory ( ! ,am]ican ,m$ical ,association 0 e/abli%$ 9 #aijf to assi/ ! ,c\ncil on ,ph>macy & ,*emi/ry 9 ! inve/igation ( propriet>y rem$ies4 ,9 accordance ) ! pr9ciple ( its f\ndation1 ! ,laboratory exam9es & *ecks ! claims made = ! composition & *emical prop]ties ( ! products "u exam9ation by ! ,c\ncil1 & :5 ^! are admitt$ to ,new & ,non(ficial ,rem$ies1 x insures ! e/abli%m5t ( te/s & /&>ds :]eby ! id5tity & purity ( ^! products may be controll$4 ,9 addition1 ! ,laboratory supplies in=mation1 secur$ by ref]5ce to *emical & ph>maceutical lit]ature or by actual analytic "w1 9 reg>d to propriet>y & un(ficial m$ic9es1 ei!r = publication 9 ,! ,j\rnal ( ! ,am]ican ,m$ical ,association or ?r\gh direct correspond5ce4 ,^? portions ( ! ,laboratory's activities :i* are ( special int]e/ to physicians & :i* 7 n includ$ 9 ! ,reports ( ! ,c\ncil on ,ph>macy & ,*emi/ry 7 includ$ 9 ! ,propag&a = ,re=m 9 ,propriet>y ,m$ic9es1 n9? edition 7#aiaf71 s f> z !y _h be5 publi%$ up to ! "t :5 ! edition 0 issu$2 ^? made dur+ ! la/ five ye>s are includ$ 9 ,"p ,,ii ( ?is volume4 ,= a detail$ report ( ! ,laboratory's "w1 ! read] is ref]r$ to ! article t foll[s on 8,! ,"w ( ! ,am]ican ,m$ical ,association ,*emical ,laboratory40 ,^? :o are int]e/$ 9 ! analysis ( drugs are ref]r$ to ! ,reports ( ! ,*emical ,laboratory issu$ annually = ! details ( ! analyses :i* h be5 made by ! ,laboratory4 ,,! ,,"w ,,( ,,! ,,am]ican ,,m$ical ,,association ,,*emical ,,laboratory,e ,w4 ,a4 ,puckn]1 ,ph>4,d4 ,e ,read be=e ! ,section on ,ph>macology & ,!rapeutics at ! ,sixty-,sev5? ,annual ,session ( ! ,am]ican ,m$ical ,association1 ,detroit1 ,june1 #aiaf4 ,! ,am]ican ,m$ical ,association ,*emical ,laboratory 0 e/abli%$ ne>ly t5 ye>s ago--9 fall ( #aijf4 ,! reason = its exi/5ce 0 prim>ily ! fact t ! ,c\ncil on ,ph>macy & ,*emi/ry f\nd x difficult to secure f outside s\rces su* help z x ne$$ 9 *eck+ up ! composition & prop]ties ( propriet>y m$ic9es "u inve/igation4 ,m$ical s*ools & simil> in/itutions 7 f\nd ready to l5d _! assi/ance 9 ph>macologic & m$ical inve/igations2 b ! *emical inve/igation requir$ ! e/abli%m5t ( a laboratory "u ! control ( ! ,am]ican ,m$ical ,association4 ,z ye>s h pass$1 ! scope ( ! laboratory has be5 ext5d$3 ,its s]vices h be5 requisition$ by ,! ,j\rnal 9 v>i\s ways4 ,?us1 :5 reque/$1 ! laboratory reviews & v]ifies ! *emical data conta9$ 9 editorials & orig9al contributions4 ,! laboratory is (t5 call$ on = in=mation z to ! "* & composition ( quack treatm5ts & s-call$ 8pat5t m$ic9es40 ,?r\gh ! columns ( ,! ,j\rnal & ?r\gh direct correspond5ce1 ! laboratory responds to reque/s ( physicians ) in=mation reg>d+ ! composition ( m$ic9es :i* !y prescribe or 9 :i* !y are int]e/$4 ,! laboratory attempts to be to ! memb]s ( ! ,am]ican ,m$ical ,association :at ! prescription ph>maci/ is1 or %\ld be1 to ! prescrib+ physician--a /oreh\se ( *emical & ph>maceutical in=mation4 ,9 ! belief t an insuffici5t famili>ity ) ! *emi/ry & ph>macy ( drugs con/itutes ! *ief reason = ! ext5sive use ( unsci5tific1 wor?less or fraudul5t propriet>y rem$ies1 ?is s]vice is r5d]$ by ! laboratory z a contribution to ! cause ( rational !rapy4 ,s9ce ! effici5cy ( ! ,am]ican ,m$ical ,association ,*emical ,laboratory w increase z its activities are bett] kn[n1 ! foll[+ m detail$ /atem5t ( its "w is (f]$3 ,,! ,,laboratory ,,& ,,! ,,c\ncil ,z /at$ 9 ! rules ( ! ,c\ncil on ,ph>macy & ,*emi/ry1 x is 8manife/ly impossible = ! ,c\ncil to inve/igate ! composition ( e complex ph>maceutical mixture 44402 8x c only give an unbias$ judgm5t on ! available evid5ce40 ,9 l9e ) ?is1 ! laboratory does n und]take to prove ! composition ( con/itution ( all new syn!tics1 nor does x attempt to det]m9e ! individual composition ( propriet>y mixtures4 ,x *ecks all claims t seem d\btful1 h[ev]1 & uses its be/ endeavors to secure correction ( mis/atem5ts ) reg>d to propriet>y rem$ies & improvem5t 9 ! quality ( ^! products4 ,fur!r1 x reexam9es1 :5 ?is seems desirable1 ! products :i* h be5 admitt$ by ! ,c\ncil to ,new & ,non(ficial ,rem$ies1 & ?us det]m9es1 f "t to "t1 _! dep5dability4 ,! fact t no product admitt$ to ,new & ,non(ficial ,rem$ies has lat] be5 %[n to be untrue to its claim$ composition is1 x is believ$1 an indication t 9 ?is respect ! laboratory has succe$$ 9 p]=m+ ! "w = :i* x 0 prim>ily creat$4 ,9 ?is connection ! "q may be ask$1 ,are _m propriet>y m$ic9es exploit$ to ! m$ical pr(ession ) false claims 9 reg>d to _! composition8 ,also x may be ask$1 ,has ! numb] ( propriet>ies m>ket$ ) false /atem5ts ( composition decreas$ s9ce ! ,c\ncil & ! laboratory began _! "w8 ,answ]+ ! latt] "q fir/3 ,!re is no d\bt t today few] propriet>y m$ic9es are be+ sold ) false claims z to composition ?an !re 7 t5 ye>s ago4 ,:5 ! ,c\ncil began its "w1 m$ical j\rnal adv]tis+ teem$ ) /atem5ts reg>d+ ! composition ( m$ic9es :i* any *emi/ famili> ) m$ic9e w\ld n hesitate at sight to br& z untrue4 ,today su* manife/ly false claims are r>e4 ,com+ to ! =m] "q3 ,_m false /atem5ts reg>d+ ! id5tity & composition ( rem$ies h be5 made 9 ignorance4 ,?is is n surpris+ :5 x is rememb]$ t ! mo/ ignorant may & d engage 9 ! manufacture ( m$ic9e4 ,besides ignorance1 h[ev]1 an accommodat+ consci5ce on ! "p ( ! manufactur] & a failure on ! "p ( ! m$ical pr(ession to appreciate ! dang] :i* lies 9 ! use ( m$ic9es ( unkn[n composition unque/ionably h greatly enc\rag$ ! m>ket+ ( falsely decl>$ m$ic9es4 ,a gl>+ illu/ration ( ! ignorance ( manufactur]s--= x is h>d to believe t any bus9ess conc]n w\ld delib]ately c\rt prosecution by ! f$]al au?orities ?r\gh false /atem5ts on labels--is ! fact t ne>ly ?irty ye>s ago ,a4 ,b4 ,lyons publi%$ a report#adg po9t+ out t ! propriet>y ,iodia 0 falsely decl>$ z to composition & t 9 #aiad :5 ! ,c\ncil exam9$ ?is prep>ation su* incorrect decl>ation appe>$ on ! label4#adh ,t _m physicians d n recognize ! dang] to _! pati5ts & _! reputation 9 ! use ( m$ic9es1 ! composition ( :i* !y d n "k1 is illu/rat$ by ! fact1 disclos$ by inquiries s5t to ! laboratory1 t physicians 7 f\nd will+ to employ an ars5ical prep>ation 7,v5>s571 adv]tis$ = intrav5\s use1 al?\gh its promot]s v\*saf$ no in=mation 9 reg>d to ! nature ( ! ars5ic comp\nd conta9$ !re94 #adg ,lyons1 ,a4 ,b43 ,detroit ,lancet1 #ahhb1 #f1 #aeg4 #adh ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #ba1 #aiad1 p4 #ahga4 ,,unreliability ,,( ,,little ,,us$ ,,drugs ,! purpose ( ! f$]al ,food & ,drugs ,act is to secure ! prosecution & puni%m5t ( all :o sell m$ic9es :i* are adult]at$ or misrepres5t$ z to composition4 ,z a matt] ( fact1 ! word+ ( ! law relat+ to ! adult]ation & misbr&+ ( drugs is su* t ! f$]al au?orities h be5 able to d little m ?an to require t ! drugs = :i* /&>ds are provid$ 9 ! ,ph>macopeia %all :5 sold comply ) ^? /&>ds4 ,simil>ly1 ^? /ates :i* attempt to improve ! quality ( drugs sold )9 _! bord]s--few /ates d effici5t "w along ^! l9es--limit _! "w to ! en=cem5t ( ! ,ph>macopeial /&>ds4 ,?is leaves ! va/ numb] ( un(ficial drugs & m$icam5ts beyond ! control ( f$]al or /ate au?orities4 ,:ile mo/ ( ^! drugs are relatively unimportant1 & :ile ! am\nts ( !m :i* are us$ are n great individually1 ! total consumption ( !m is l>ge4 ,) a view ( furni%+ to physicians /&>ds = drugs ( ?is sort ! ,c\ncil has describ$ 9 ,new & ,non(ficial ,rem$ies n only di/9ctly propriet>y drugs1 b also "s ( ! un(ficial drugs :i* are app>5tly ( !rapeutic value & us$ to a consid]able ext5t4 ,aid+ ! ,c\ncil 9 ?is l9e ( endeavor1 ! laboratory has attempt$ to e/abli% /&>ds = ^! little us$ drugs1 & ,new & ,non(ficial ,rem$ies1 #aiaf1 provides /&>ds = su* un(ficial & non-propriet>y drugs z qu99 & urea hydro*lorid qu991 tannate1 sodium acid phosphate1 & sodium p]borate4 ,an example ( "w :i* furni%$ mu* ne$$ /&>ds = an un(ficial article is ! inve/igation ( z9c p]manganate by ,w4 ,s4 ,hilp]t4#adi ,ref]5ce to ! publi%$ reports ( ! laboratory w give an idea ( ! am\nt ( "w su* /&>dization entails4 ,a ref]5ce to ! new ,u4 ,s4 ,ph>macopeia1 :5 ?is comes f ! press1 w %[ t a consid]able numb] ( un(ficial articles describ$ 9 ,new & ,non(ficial ,rem$ies h be5 admitt$ to ! ,ph>macopeia along ) ! /&>ds work$ out 9 ?is laboratory4 #adi ,z9c p]manganate1 ,j4 ,a4 ,m4 ,a41 ,feb4 #f1 #aiji1 p4 #dhh2 ,reports ,*em4 ,lab4 #b3ae1 #aiji4 ,:ile 9 a way ! "w done 9 connection ) ^! less important drugs has attract$ little att5tion f ! m$ical pr(ession1 x has _h an effect on ph>maceutical manufactur]s4 ,9 ! pa/1 ph>maceutical h\ses1 ev] anxi\s to m>ket some?+ new1 on ! slighte/ provocation h plac$ on ! m>ket1 9 ! =m ( pills1 p[d]1 elixir1 ampule1 etc41 e drug = :i* "s sort ( m$ical recomm5dation c\ld be f\nd4 ,9 m>ket+ ^! dosage =ms1 ! manufactur] has too (t5 be5 little conc]n$ ab\t ! quality ( ! drugs us$4#aej ,j at pres5t1 = in/ance1 "s int]e/ is be+ %[n 9 iron cacodylate2 b :ile manufactur]s appe> to be mo/ ready to take advantage ( ?is int]e/ by (f]+ ! drug 9 ! =m ( ampules1 etc41 !y h giv5 little help t[>d ! e/abli%m5t ( /&>ds = ?is ars5ic comp\nd4 ,manufactur]s are ev] ready to sell drugs ( all sorts1 b 9 view ( ! small dem& !y _c or w n safegu>d ! id5tity & purity ( su* drugs4 ,a fur!r illu/ration ( ! unreliability ( un(ficial drugs is ! rec5t report by ,levy & ,r[ntree#aea %[+ n only t ! v>i\s dosage =ms ( emet9 hydro*lorid obta9$ f diff]5t manufactur]s v>i$ f manufactur] to manufactur]1 b also t ! product ( ! same manufactur] 0 v>iable & t ! supply furni%$ by "o ph>maceutical firm 0 s toxic z to make its use dang]\s4 #aej ,! ,unreliability ( ,unimportant ,m$icam5ts1 ,! ,j\rnal ,a4 ,m4 ,a41 ,sept4 #bh1 #aiab1 p4 #aaef4 #aea ,levy1 ,r4 ,l41 & ,r[ntree1 ,l4 ,g43 ,on ! ,toxicity ( ,v>i\s ,comm]cial ,prep>ations ( ,emet9 ,hydro*lorid1 ,ar*4 ,int4 ,m$41 ,m>*1 #aiaf1 p4 #dbj4 ,,! ,,analysis ,,( 8,,pat5t ,,m$ic9es0 ,9 ! preface to ! fir/ annual report ( ! *emical laboratory x 0 /at$ t ! laboratory 8occasionally takes up ! exam9ation ( #8pat5t m$ic9es' 4440 ,at t "t x 0 felt t ! widespread use by ! m$ical pr(ession ( irrational & ev5 secret m$ic9es made x necess>y to devote ! laboratory's att5tion to ! correction ( ?is evil4 ,z ! ye>s h pass$ on1 ^! conditions h be5 rem$i$ to "s ext5t1 at lea/ s f> z *emical analysis c correct !m4 ,on ! o!r h&1 public op9ion has be5 ar\s$ to ! _m evils connect$ ) ! exploitation ( 8pat5t m$ic9es10 & has m & m insi/5tly dem&$ t ! m$ical pr(ession aid 9 ! correction ( ?is evil4 ,accord+ly1 ! laboratory has paid mu* att5tion to ! analysis ( 8pat5t m$ic9es0 dur+ ! la/ few ye>s4 ,z ! *ief asset ( 8pat5t m$ic9es0 is ! elem5t ( secrecy :i* surr\nds _! composition1 x is hop$ t ! laboratory's analysis ( su* widely us$ 8pat5t m$ic9es0 z ,nature's ,creation1#aeb ,mayr's ,wond]ful ,/oma* ,rem$y1#aec ,sanatog51#aed ,eckman's ,alt]ative1#aee ,tonsil9e1#aef & ,bromo-,qu99#aeg has be5 wor? ! labor4 ,9 addition1 ! "w ( ?is laboratory has be5 publi%$1 includ+ n only ! results ( its analyses1 b also ! me?ods :i* are us$4 ,9 view ( ! de>? ( publi%$ reports reg>d+ ! me?ods us$ 9 ! analysis ( 8pat5t m$ic9es10 x is hop$ t ?is feature ( ! laboratory's "w has be5 ( aid to *emi/s engag$ 9 simil> "w4 #aeb ,! ,j\rnal ,a4 ,m4 ,a41 ,m>* #e1 #aiaj1 p4 #hjf4 #aec ,! ,j\rnal ,a4 ,m4 ,a41 ,aug4 #ai1 #aiaa1 p4 #fga4 #aed ,! ,j\rnal ,a4 ,m4 ,a41 ,april #bj1 #aiab1 p4 #abaf4 #aee ,! ,j\rnal ,a4 ,m4 ,a41 ,april #bg1 #aiab1 p4 #abih4 #aef ,! ,j\rnal ,a4 ,m4 ,a41 ,april #d1 #aiad1 p4 #aaji4 #aeg ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #bg1 #aiae1 p4 #aicb4 ,! laboratory's activities along ^! l9es h done mu* to disc\nt ! claim ( propriet>y manufactur]s t *emical analysis is unable to det]m9e ! "* ( 8pat5t m$ic9es40 ,! rec5t ,w9e ( ,c>dui trial has br\ght x out prom95tly t *emical analysis c det]m9e ! pres5ce ( pot5t con/itu5ts1 & t 8pat5t m$ic9es0 :i* fail to reveal su* pot5t +r$i5ts to ! analy/ may safely be put d[n z wor?less4 ,! demon/ration t ! ess5tial composition ( m$ic9al prep>ations may be det]m9$ by *emical analysis %\ld also prove an effective answ] to ! manufactur]s 9 _! prote/ aga9/ ! requirem5t1 n[ be+ urg$ = enactm5t into law 9 v>i\s /ates1 t ! m$ic9al +r$i5ts ( _! w>es mu/ be decl>$ on ! label4 ,manufactur]s h held t ?is w\ld lay !m op5 to competition ) imitations & sub/itutions4 ,! possibility ( *emical id5tification proves1 h[ev]1 t secrecy ( composition1 ?\gh x prev5ts consum]s f kn[+ ! "* ( a 8pat5t m$ic9e10 w n be a h9drance to ! imitator & sub/itutor4 ,,id5tity ,,( ,,drugs ,,us$ ,,9 ,,inve/igations ,9 ! pa/1 mu* ( ! exp]im5tal "w 9 m$ic9e has s]i\sly suff]$ 9 t ! id5tity ( ! mat]ial us$ 9 su* inve/igations 0 n e/abli%$4 ,9 view ( ?is ! laboratory has wat*$ ! contributions submitt$ to ,! ,j\rnal1 & :5ev] necess>y & feasible has urg$ ! au?ors to id5tify _! mat]ial be=e publication ( ! f9d+s4 ,= in/ance1 a numb] ( /a9+ ag5ts--s-call$ 8anil9 dyes0--h be5 f\nd to possess !rapeutic action4 ,s9ce ! id5tity ( _m ( ^! /a9+ ag5ts is today ess5tially secret1 ! laboratory has urg$ ?r\gh ,! ,j\rnal t ^? :o exp]im5t ) ^! sub/ances make an ef=t to det]m9e _! id5tity :5ev] possible & to give pref]5ce to ^? ! *emical id5tity ( :i* is kn[n4 ,! ne$ = su* id5tification has be5 discuss$ 9 ! reports ( ! laboratory4#aeh ,! am\nt ( "w involv$ 9 ! *emical id5tification ( drugs us$ = exp]im5tal "w is illu/rat$ 9 a contribution entitl$ 8,an ,exam9ation ( ,sev]al ,comm]cial ,specim5s ( ,opium ,alkaloids or ,_! ,salts40#aei by ,l4 ,e4 ,w>r51 9 :i* 0 det]m9$ ! id5tity ( ! v>i\s opium products us$ 9 an inve/igation by ,d4 ,i4 ,ma*t1 c>ri$ out "u a grant ( ! ,!rapeutic ,rese>* ,committee4 #aeh ,reports ,a4 ,m4 ,a4 ,*emical ,laboratory1 #aiab1 v1 #ajb4 #aei ,am4 ,j\r4 ,ph>m41 #aiae1 #hg1 #dci4 ,,! ,,laboratory ,,& ,,ph>maceutical ,,lit]ature ,9 ! pa/ mu* ( ! in=mation 9 reg>d to ! composition & prop]ties ( m$ic9es :i* has appe>$ 9 ph>maceutical j\rnals has n become available to m$ic9e4 ,9 _m cases m$ical j\rnals c\ld n af=d to publi% su* data because ?is w\ld h be5 contr>y to ! int]e/ ( _! adv]tis]s1 & h5ce ! publications reg>d+ ! irrational "* ( ,lactopept9e1 ( ,bromidia1 etc41 :i* appe>$ 9 ! ph>maceutical j\rnals did n become a matt] ( common m$ical k4 ,?r\gh ! laboratory an attempt has be5 made to keep ! m$ical pr(ession in=m$ 9 reg>d to ph>maceutical lit]ature4 ,! laboratory has a good work+ ph>maceutical & *emical libr>y1 & subscribes to ! important ,am]ican & =eign ph>maceutical & *emical publications4 ,! discussion ( new rem$ies1 su* z m$9al & sodium v]onal1#afj salv>san1 atoxyl & arsacet91#afa & neosalv>san#afb soon aft] _! introduction1 illu/rates ! "w ( ! laboratory along ^! l9es4 #afj ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #bc1 #aiji1 p4 #caa4 #afa ,! ,j\rnal ,a4 ,m4 ,a41 ,dec4 #ca1 #aiaj1 pp4 #bcjc & #bcad4 #afb ,! ,j\rnal ,a4 ,m4 ,a41 ,oct4 #e1 #aiab1 p4 #abie4 ,,! ,,laboratory',s ,,ef=ts ,,t[>d ,,rational ,,prescrib+ ,! laboratory naturally is 9 ?or\gh sympa?y ) ! pres5t day ef=ts t[>d a m rational use ( drugs1 z exemplifi$ 9 ! ,c\ncil's publication 8,useful ,drugs40 ,two rec5t contributions ( ! laboratory may be cit$ z a fur!r support ( ! movem5t = limit+ prescrib+ to ! m widely us$ drugs4 ,9 l9e ) ! g5]al t5d5cy ( manufactur]s to put out all sorts ( modifications & ass]t$ improvem5ts ov] (ficial sub/ances1 !re h be5 plac$ on ! m>ket a numb] ( prep>ations said to repres5t "s improvem5t ov] ! ph>macopeial ,blaud pills4 ,! report1 8,! ,quality ( ,comm]cial ,blaud's ,pills10#afc by ,l4 ,e4 ,w>r51 %[s t ! ord9>y ph>macopeial ,blaud pill is 9 e way ! equal ( ! semipropriet>y prep>ations claim$ to be improvem5ts4 ,fur!r1 ! exam9ation ( ! v>i\s br&s ( sodium & !obrom9 salicylate z comp>$ ) ! prep>ation diuret9 by ,p4 ,n4 ,lee*#afd %[s t ! =m] prep>ations1 sold at #ce c5ts p] ounce at ! "t ! exam9ation 0 made1 are fully ! equal ( ! propriet>y ,diuret91 :i* !n co/ ! druggi/ #a4ge p] ounce4 #afc ,! ,j\rnal ,a4 ,m4 ,a41 ,april #ag1 #aiae1 p4 #acdd4 #afd ,! ,j\rnal ,a4 ,m4 ,a41 ,april #d1 #aiad1 p4 #aajh4 ,,! ,,laboratory ,,z ,,an ,,in=mation ,,bureau ,x is g5]ally admitt$ t ! propriet>y m$ic9e bus9ess1 p>ticul>ly ! exploitation ( complex mixtures1 atta9$ ! ext5sive vogue :i* x has or _h because in/ruction 9 m$ical s*ools 0 defici5t 9 mat]ia m$ica1 ph>macy & *emi/ry4 ,z a result ( lack ( k along ^! l9es1 ! "y graduate aft] "s trial became fe>ful ( =mulat+ 8 own prescriptions1 & 9 "t became dep5d5t on ph>maceutical firms :i* provid$ him ) m$ic9es ready to disp5se4 ,t physicians h be5 insuffici5tly tra9$ 9 reg>d to ! ph>macy & *emi/ry ( drugs has (t5 be5 emphasiz$ 9 ph>maceutical j\rnals :]e prescriptions conta9+ incompatible drugs are report$ & :]e ev5 plans are br\ght =w>d :]eby ! ph>maceutical pr(ession may aid 9 rem$y+ ?is difficulty4 ,dur+ my ph>maceutical exp]i5ce ,i 0 (t5 sorely vex$ z to :at to d :5 prescriptions conta9$ drugs :i* on mix+ w\ld und]go decomposition :i* ! physician surely did n anticipate4 ,i rememb] well a prescription direct+ t potassium p]manganate be made into pills ) extract ( g5tian & o!r ?+s1 & h[1 ! physician hav+ spurn$ ! sugge/ion to modify ! prescription s z to avoid decomposition ( ! p]manganate1 ,i 0 oblig$ to select a mort>1 g5tly triturate ! drugs until a conflagration 0 />t$1 & to f9i% ! prescription aft] ! combu/ion _h subsid$4 ,h[ev]1 9 my ph>maceutical exp]i5ce ,i g5]ally f\nd ! physician mo/ ready to receive sugge/ions f ! ph>maci/ :i* w\ld prev5t incompatibilities1 improve ! palatability & appe>ance ( 8 prescriptions1 & protect ! pati5t f unnecess>y exp5se4 ,simil>ly x has be5 my exp]i5ce s9ce ! e/abli%m5t ( ! ,association's laboratory t physicians are anxi\s to receive in=mation 9 reg>d to ! mat]ia m$ica1 ph>macy & *emi/ry ( drugs4 ,z ! druggi/ e>ns ! respect & support ( ! physician :5 he makes available to him ! ph>maceutical k & exp]i5ce :i* he has1 s ?is laboratory has aim$ to ga9 ! endorsem5t ( ! ,am]ican ,m$ical ,association memb]%ip by furni%+ to physicians in=mation 9 reg>d to ! composition1 *emi/ry & ph>macy ( drugs ?r\gh replies 9 ! ,qu]y & ,m9or ,notes ,dep>tm5t ( ,! ,j\rnal z well z ?r\gh direct correspond5ce4 ,x has be5 mo/ gratify+ to ! laboratory t ,! ,j\rnal receives an increas+ numb] ( inquiries bo? z reg>ds ! *emical & ph>maceutical que/ions involv$ 9 ! writ+ ( prescriptions & z reg>ds ! composition ( secret & semisecret propriet>ies 7(t5 because !y are prescrib$ by ! inquir]'s colleague7 & 8pat5t m$ic9es0 7:i* are tak5 by 8 pati5t74 ,! laboratory has tri$ its be/ to answ] ! _m inquiries receiv$4 ,_m ( ! que/ions :i* come 9 c be answ]$ by a ph>maci/ or *emi/ )\t hesitation4 ,o!rs1 p>ticul>ly z to ! composition ( m$ic9es1 ! laboratory has be5 able to answ] by ref]5ce to its libr>y & its ext5sive c>d index4 ,/ill o!rs h requir$ exp]im5tation & *emical analysis4 ,:ile1 z /at$ a mom5t ago1 ! laboratory has enc\rag$ ! s5d+ ( inquiries & has e>ne/ly /riv5 to furni% ! in=mation ask$ =1 x is obvi\s t ! am\nt ( *emical "w :i* c be done is limit$4 ,! small size ( ! laboratory =ce1 consi/+ ( ?ree *emi/s engag$ 9 actual analytical "w1 makes x necess>y to select = inve/igation ^? problems :i* %all be ( g5]al int]e/ to ! m$ical pr(ession4 ,z ! ,am]ican ,m$ical ,association is national 9 its scope1 ! laboratory has held t x c d analytical "w only :5 su* "w w be ( g5]al int]e/ to physicians & ( value bo? to ! m$ical pr(ession & ! public4 ,9 view ( ?is x has refra9$ f und]tak+ analyses :i* w\ld b5efit only ! physician mak+ ! inquiry & possibly 8 pati5t4 ,! laboratory fur!r has n felt ju/ifi$ 9 und]tak+ "w ( m]ely local int]e/2 in/ead x has us$ its endeavors to secure ! inve/igation ( su* local problems by municipal or /ate au?orities4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #be1 #aiaf47 ,,lead ,,9 8,,akoz0 ,akoz is a m9]al product sold by ! ,natura ,company ( ,san ,francisco1 & said to possess mo/ rem>kable m$ic9al prop]ties4 ,a circul> issu$ by ! ,natura ,company beg9s ?us3 8,:ile sci5ti/s h be5 /riv+ ?r\gh ! c5turies to comp\nd rem$ies = man's v>i\s ills1 ,nature1 greate/ *emi/ ( !m all1 has be5 work+ wond]s 9 h] crucibles & has a*iev$ results f> beyond man's greate/ expectation40 8,nature's *ief h&icap has be5 ! difficulty ( plac+ h] gifts 9 ! h&s ( ^? :om %e w\ld b5efit4 ,by accid5t or fate1 z y w1 "o ( ,nature's greate/ m$ic9al products has j be5 discov]$4 ,x is ! m9]al giv5 ! "n ( ,akoz by ,john ,d4 ,mack5zie1 presid5t & manag] ( ! ,natura ,company ( ,san ,francisco1 :i* is n[ giv+ ?is r>e rem$y ( ,nature to ! public40 ,! circul> !n describes h[ ! p[] ( ! 8r>e rem$y0 to cure rheumatism is claim$ to h be5 discov]$ & ass]ts t3 8,akoz 0 subject$ to e kn[n sci5tific te/ be=e be+ pres5t$ to ! public4 ,x 0 practically det]m9$ t ! ore conta9$ a new elem5t hav+ radium-l qualities b conta9+ no?+ poison\s or h>mful40 8,aft] ! curative virtues ( ,akoz = rheumatism1 /oma* tr\ble1 eczema1 cat>rh1 piles1 ulc]s & num]\s o!r ailm5ts _h be5 fully e/abli%$ 9 *emical laboratory1 hospital cl9ic1 & ! private practice ( physicians 9 v>i\s p>ts ( ! _w1 ,mr4 ,mack5zie effect$ ! organization ( ! ,natura ,company40 ,?is product1 put up 9 ! =m ( 8,akoz ,m$ic9al ,m9]al ,wat]1 ,akoz ,o9tm5t1 ,akoz ,p[d] & ,akoz ,suppositories10 0 submitt$ to ! ,c\ncil on ,ph>macy & ,*emi/ry = consid]ation "s ye>s ago ) ! claims t 8,akoz0 itself consi/s ess5tially ( z9c sulphid1 b>ium sulphate & alum9um oxid4 ,! submitt$ analysis did n decl>e ! pres5ce ( lead or ( uranium ?\gh 8special te/s0 = ! latt] _h be5 8run40 ,)\t *eck+ ! claim$ composition1 ! ,c\ncil at t "t refus$ recognition to ,akoz because !re 0 no evid5ce submitt$ = ! v extravagant & altoge!r improbable !rapeutic claims4 ,aft] ! ,c\ncil _h conclud$ ! consid]ation ( ,akoz a lett] 0 receiv$ f a ,cali=nia physician /at+ t accord+ to an analysis submitt$ to him ,akoz conta9$ #j4cd p] c5t4 ( lead 9 ! =m ( lead sulphate4 ,! correspond5t held t1 :ile ! lead sulphate did n pass into solution1 p]sons dr9k+ ! sup]natant liquid f ,akoz 7! 8m$ic9al m9]al wat]0 is made by add+ ,akoz to ord9>y wat]7 might inadv]t5tly swall[ "s ( ! p[d]4 ,he 0 incl9$ to believe t ?is might acc\nt = a case ( lead poison+ :i* _h be5 obs]v$ 9 a pati5t :o _h be5 tak+ ,akoz4 ,inasmu* z x has be5 demon/rat$ by ,c>lson & ,woelfel 7,c>lson1 ,a4 ,j41 & ,woelfel1 ,a43 ,solubility ( ,lead ,sulphate & ,basic ,lead ,c>bonate 9 ,human ,ga/ric ,juice4444 ,9 ,hygi5e ( ! ,pa9t]'s ,trade by ,alice ,hamilton1 ,bull4 ( ,u4 ,s4 ,bureau ( ,labor ,/ati/ics ,no4 #abj1 ,may #ac1 #aiac1 pp4 #bb-cb7 t ev5 small quantities ( lead sulphate :5 tak5 into ! sy/em = a long "t1 h produc$ lead poison+1 ! laboratory deem$ x important t ! products be exam9$ = lead4 ,a specim5 ( 8,akoz ,p[d]0 submitt$ to ! ,c\ncil by ! ,natura ,company & conta9$ 9 a sift]-top c 0 tak5 = analysis4 ,! cont5ts ( ! c 7 ?or\ghly mix$4 ,to det]m9e ! pres5ce ( lead "s ( ! p[d] 0 extract$ ) ammonium acetate solution4 ,details ( ,analysis ,qualitative te/s %[$ ! pres5ce ( lead & sulphate 9 ! ammonium acetate solution4 ,! pres5ce ( lead 0 demon/rat$ by ! black precipitate ) hydrog5 sulphid1 ! yell[ precipitate ) potassium *romate & ! typical yell[i% cry/all9e precipitate ) potassium iod94 ,! pres5ce ( sulphates 9 ! ammonium acetate solution 0 %[n by ! =mation ( a precipitate ) b>ium *lorid solution & acetic acid4 ,two #b gm4 samples 7,a & ,b7 7 tak5 = ! quantitative det]m9ation ( lead4 ,ea* 0 treat$ repeat$ly ) a saturat$ solution ( ammonium acetate until ! filt]$ ammonium acetate solution gave no appreciable precipitate ) potassium *romate solution4 ,! ammonium acetate extractions f ea* specim5 7 comb9$ & treat$ ) hydrog5 sulphid1 ! precipitat$ lead sulphid filt]$ (f & wa%$1 & ignit$ ) sulphuric acid at a l[ heat4 ,! crucible ) ! residue ( lead sulphate 0 cool$ & weigh$4 ,a yield$ #j4jdfi gm41 or #b4cd p] c5t41 lead sulphate4 ,b yield$ #j4jddj gm41 or #b4bj p] c5t41 lead sulphate4 ,:ile ! laboratory has no evid5ce to %[ t ! am\nt ( lead-sulphate ?us f\nd to be pres5t is likely to prove h>mful1 ! foll[+ caution>y lett] 0 s5t to ! ,natura ,company3 8,accord+ to in=mation :i* y s5t to ! ,c\ncil on ,ph>macy & ,*emi/ry y\r product 8,akoz0 does n conta9 lead4 ,9 view ( reports receiv$ ascrib+ symptoms1 result+ f ! int]nal use ( ,akoz1 to *ronic lead poison+1 an exam9ation ( a specim5 ( ,akoz ,p[d]1 :i* y s5t to ! ,c\ncil1 0 made4 ,?is exam9ation indicates ! pres5ce 9 ,akoz ,p[d] ( ab\t #b4b p] c5t4 lead sulphate4 ,9 view ( ! disa/r\s results likely to foll[ ! int]nal use ( products conta9+ ev5 small am\nts ( lead1 ! above is submitt$ to y = y\r consid]ation40 ,no reply to ! =ego+ 0 receiv$ f ! ,natura ,company4--7,f ,reports ,a4 ,m4 ,a4 ,*emical ,laboratory1 #aiaf1 p4 #ajc47 ,,sodium ,,acetate ,,9 ,,w>m+ ,,bottles ,rec5tly ! laboratory's att5tion 0 call$ to ! 8,thermo,r ,wat]less ,hot ,bottle10 manufactur$ by ! ,royal ,!rmophor ,sales ,co41 ,new ,york4 ,! foll[+ claims appe> 9 "o ( ! adv]tis+ pamphlets3 8,!re is moi/ heat40 8,rubb] hot-wat] 78 8 87 naturally give a moi/ heat40 ,x 7,thermo,r7 gives a dry heat4 8,! #8,,!rmor' ,bottle is n a hot-wat] bottle--x acts on a pr9ciple t is entirely diff]5t & new40 8444 gives y fir/1 la/ & all ! "t a fix$ degree ( dry usable heat--a heat t holds /eadily at #abe degrees = fully twelve h\rs--y w easily see :y x is t #8,,!rmor' relieves & cures :]e hot-wat] bottles fail40 ,! bottle 0 nickel plat$1 #h-c_/h in*es 9 diamet] & #a-a_/b in*es ?ick1 & 9 appe>ance resembl$ an exagg]at$ clos$ ,+]soll wat*4 ,! bottle is n flexible & weighs #c-a_/b p\nds4 ,! cont5ts consi/$ ess5tially ( sodium acetate4 ,?is salt melts :5 heat$4 ,:5 x cools ! temp]ature inside ! bottle is relatively con/ant1 z x w rema9 at ! 8freez+ po9t0 until all ( ! sodium acetate has solidifi$4 ,! duration ( ! "t t x rema9s w>m :5 well wrapp$ is simply 9 inv]se proportion to ! conductivity ( ! surr\nd+ environm5t4 ,:5 two ord9>y t[els 7 c>efully arrang$ ab\t x1 ! air betwe5 ! bottle & ! wrapp+s 0 ma9ta9$ at a temp]ature ( #dj-ej ,c4 7#ajd-abb ,f47 = a p]iod ( eight h\rs4 ,! company's implication t ! heat giv5 out by ! ,!rmor bottle diff]s f t giv5 out by an ord9>y hot-wat] bottle is an absurdity4 ,! use ( sodium acetate 9 ! prep>ation ( w>m+ bottles has be5 9 practice _m ye>s1 & is n 8a pr9ciple t is entirely diff]5t & new40 ,fur!rmore1 ! !rapeutic claims are extravagant4--7,f ,reports ,a4 ,m4 ,a4 ,*emical ,laboratory1 #aiaf1 p4 #aje47 ,,anti-,,syphilitic ,,comp\nd 7,,swe5y7 ,a specim5 ( ,anti-,syphilitic ,comp\nd 7,swe5y71 sold by ,! ,national ,laboratories ( ,pittsburgh1 0 receiv$ f a physician4 ,! package 7#a ounce size7 has be5 op5$ by ! s5d] & ab\t ?ree f\r?s ( ! cont5ts remov$4 ,f ! r indef9ite /atem5ts 9 ! lit]ature ( ! manufactur] x is ga!r$ t ! prep>ation is claim$ to be a 8/]ile1 oily emulsion0 :i* conta9s #a_/bj gra9 ( m]curic b5zoate 9 ea* #e m9ims1 toge!r ) "s sodium *lorid4 ,accord+ to in=mation furni%$ by ! ,laboratory's correspond5t1 ! price ask$ = ! prep>ation is #ae an ounce4 ,! quantity ( ! prep>ation receiv$ 0 too small to p]mit a complete exam9ation1 b1 f ! te/s :i* x 0 possible to make1 ! prep>ation appe>s to be an aque\s solution conta9+ "s susp5d$ matt] & small quantities ( m]curic b5zoate & a *lorid1 presumably sodium *lorid4 ,!re 0 no evid5ce ( ! pres5ce ( an 8oily emulsion40 ,quantitative te/s indicat$ ! pres5ce ( a m]curic salt1 equival5t to ab\t #j4bghc gm4 ( cry/alliz$ m]curic b5zoate p] #ajj c4c4 ,?is corresponds to ab\t #j4jjjhf gm4 9 ea* #e m9ims1 or ab\t #bf4e p] c5t4 ( ! am\nt claim$4--7,f ,reports ,a4 ,m4 ,a4 ,*emical ,laboratory1 #aiaf1 p4 #ajf47 8,,ambr9e0 ,,& ,,p>aff9 ,,films,f ,paul ,ni*olas ,lee*1 ,ph4,d4 ,f ,contribution f ! ,*emical ,laboratory ( ! ,am]ican ,m$ical ,association4 ,9 ! la/ ye> or s1 ! hot-wax or p>aff9 treatm5t ( burns has be5 widely discuss$ bo? 9 m$ical & lay p]iodicals4 ,al?\gh ! treatm5t is simply a modification ( ! well-kn[n use ( oil & o9tm5ts1 x has receiv$ unusual att5tion1 ow+ to ! widespread s5sationalism foll[+ ! exploitation 9 ,france ( a secret & !re=e my/]i\s mixture1 8,ambr9e10 ! =mula ( ,dr4 ,b>! de ,s&=t4 ,ow+ to ?is publicity1 x seem$ desirable to inve/igate ! *emical composition1 & to comp>e its physical prop]ties ) o!r waxlike sub/ances4 8,ambr9e0 is promot$ z a dress+ = burns1 fro/bites1 neuritis1 v>icose ulc]s1 phlebitis1 neuralgia1 rheumatism1 sciatica1 g\t1 etc4 ,x is a smoky-appe>+ sub/ance1 resembl+ p>aff9 9 consi/5cy & )\t odor4 ,= application1 8,ambr9e0 is melt$ & appli$ to ! w\nd ei!r ) a bru% or ) a specially devis$ atomiz]4 ,x cools quickly1 & leaves a solid1 protect+ film4 ,illu/ration3 - - - - - - - - - - - - - - - - - ,,hyp]!rmality ,a ,,reality4 ,hyp]!rmality is a fact1 h[ev]1 ?r\gh ! ag5cy ( a k]i-res9\s product :i* has be5 us$ 9 ,france s9ce #aijj "u ! "n ( ,l',ambr9e4 ,hyp]!rm9e1 z ! rem$ial ag5t w be kn[n 9 ?is c\ntry1 is a comb9ation ( sev]al k9ds ( waxes & res9s1 sci5tific- ally bl5d$ & conta9+ no m$ic9al elem5ts :atev]4 ,x comes 9 ! =m ( waxy flakes4 ,x melts at #abd & on cool+ resembles a d>k color$ wax4 ,hyp]!rm9e is ! discov]y ( ,dr4 ,b>! de ,s&=t1 an em95t retir$ ,fr5* naval surgeon & a memb] ( num]\s =eign m$ical societies4 ,he - - - - - - - - - - - - - - - - - 8,ambr9e0 has be5 exploit$ 9 ! ,unit$ ,/ates = "s "t4 ,to physicians x 0 sold "u ! "n 8,hyp]!rm9e40 ,above is a photographic reproduction 7r$uc$7 ( a portion ( a booklet describ+ 8,hyp]!rm9e10 :i* has be5 9 ,! ,j\rnal (fice = "s ye>s4 ,illu/ration3 - - - - - - - - - - - - - - - - - ,,hyp]!rm9e',s ,,field4 ,hyp]!rm9e c be us$ 9 practically all 9- flammatory conditions4 ,dur+ ! pa/ t5 ye>s1 "u ! "n ( ,l',ambr9e1 our product has be5 widely us$ 9 ! hospitals 9 ,france1 z well z 9 private practice1 & we h v _m cl9ical reports on a v>iety ( subjects4 ,its greate/ use has be5 9 su* conditions z sciatica1 lumbago1 articul> & muscul> rheumatism1 g\t1 ar?ritis1 burns ( all degrees1 pneumonia1 bron*itis1 or*it- is1 buboes1 s(t *ancres1 p]itonitis1 dysm5or- rhea1 ad5itis1 ma/itis1 p]io/itis1 synovitis1 conjunctivitis1 iritis1 irido-*oroiditis1 abscess- es1 bruises1 furuncles1 :itl[1 p>ony*ia1 c>- buncles1 moi/ eczema & simil> d]matological affections1 & v>icose & tub]cul> ulc]s4 - - - - - - - - - - - - - - - - - ,photographic reproduction 7r$uc$7 f ! 8,hyp]!rm9e0 78,ambr9e07 booklet recomm5d+ x = use 9 rheumatism1 g\t1 pneumonia1 buboes1 dysm5orrhea1 eczema1 tub]cul\s ulc]s1 etc4 ,x is said t de ,s&=t 8/umbl$ on ?is treatm5t by accid5t40#afe ,be+ a suff]] f rheumatism1 he _h be5 b5efit$ by hot mud ba?s2 on return+ home he s\ght a sub/itute1 & f9ally made a mixture ( p>aff91 oil ( amb] & amb] res94 ,?is 0 appli$ hot1 s]v+ z a firm p\ltice4 8,ye>s lat]1 he w5t on s]vice to a railway 9 ,*9a & 0 9 ,yunnan at ! "t ( ! inc5di>y insurrection1 & _m badly burn$ ,*9ese 7 br\ght 9 = treatm5t4 ,rememb]+ t ,ambroise ,p> treat$ su* cases ) hot oil1 he tri$ ! effect ( cov]+ ! burn ) 8 melt$ ambr9e1 :i* at once glazes ov]1 =m+ a coat imp]vi\s to ! air1 & 8 pati5ts ceas$ to suff]40#aff #afe ,! ,outlook1 ,jan4 #ag1 #aiag1 p4 #ajj4 #aff ,m$4 ,rec41 ,new ,york1 ,jan4 #bg1 #aiag1 p4 #afj4 8,ambr9e0 has be5 sold 9 ,am]ica "u two names3 8,hyp]!rm9e10 z exploit$ to physicians1 & 8,!rmoz9e10 z adv]tis$ to ! public4 ,physical comp>ison alone %[s t ,ambr9e z n[ sold diff]s f 8,hyp]!rm9e0 ( a few ye>s ago2 ! probable reason is t 8,ambr9e0 has *ang$ its =mula4 ,?is is borne out by ,matas1#afg :o /ates t de ,s&=t 8admitt$ t ,ambr9e 0 a comp\nd ( p>aff91 oil ( sesame & res9s1 b 0 n at lib]ty to divulge its exact composition1 z ! =mula & manufacture ( ?is sub/ance 0 n[ ! prop]ty ( a private corporation1 :i* 0 exploit+ x z a propriet>y & secret rem$y40 ,! lat] =mula diff]s f ! orig9al4 #afg ,matas1 ,rudolph3 ,burns ,treat$ ) ,p>aff9 ,mixtures1 ,new ,orleans ,m$4 & ,surg4 ,j\r41 ,april1 #aiag1 p4 #fha4 ,besides ! =ego+ p>aff9 prep>ations1 two o!rs h rec5tly be5 plac$ on ! ,am]ican m>ket1 8,p>res9e0 7nonsecret7 & 8,mul5e0 7secret74 ,,analysis ,,( ,,ambr9e 8,ambr9e0 comes 9 rectangul> cakes1 ab\t #a-a_/b in*es wide1 #f in*es long & #a_/b in* ?ick4 ,x is mod]ately s(t1 b some:at brittle at ord9>y room temp]ature4 ,a black sub/ance is pres5t1 :i* evid5tly settles out dur+ ! comp\nd+1 z 9 "o side ( ! cake ^! p>ticles c be cle>ly disc]n$ by hold+ x up to ! light2 9 ! o!r side !re are no susp5d$ p>ticles4 ,:5 melt$1 ! solution is n cle>1 & a s$im5t =ms4 ,! melt+ po9t 7,u4 ,s4 ,p4 me?od2 see lat]7 is #dh4d ,c4 ,! pla/icity & ductility#afh are #bg & #cj4e1 respectively4 ,x is pliable & /rong at body temp]ature4 ,! saponification numb] & acid numb] are bo? v l[1 b a fatty oil is pres5t4 ,te/s indicat$ oil ( sesame4 ,n9ety-eight p] c5t4 ( 8,ambr9e0 is soluble 9 e!r2 ?is soluble portion may be treat$ ) l[-boil+ ligro9 7petroleum e!r71 out ( :i*1 on /&+1 a black asphalt-l sub/ance sep>ates4 ,( ! e!r-insoluble sub/ance1 #fe p] c5t4 is soluble 9 *lor(orm4 ,! rema9+ insoluble sub/ance conta9s a small am\nt ( silica & vegetable fib]4 ,! p>aff9 obta9$ f 8,ambr9e0 melt$ at #dh4f ,c4 ,z a result ( v>i\s exp]im5ts1 x appe>s t ! composition ( 8,ambr9e0 is ess5tially z foll[s3 ,p>aff9 7,m4 ,p4 #dh4f ,c47 #ig4j p] c5t4 ,fatty oil 7sesame87 #a4e p] c5t4 ,asphalt-l body #j4e p] c5t4 ,color+ matt]1 & undet]m9$ #a4j p] c5t4 ----- #ajj4j #afh ,^! det]m9ations w be describ$ lat]4 ,,o!r ,,propriet>y ,,films ,a cursory exam9ation ( 8,mul5e10 manufactur$ by ! ,mul5e ,company1 ,pittsburgh1 0 also made4 ,?is appe>s to conta9 p>aff91 beeswax1 a fat-soluble r$ dye & consid]able ros94 ,:5 heat$ c>efully 9 a beak]1 ! ros9 8/icks0 to ! bottom1 & does n g into solution readily4#afi #afi ,:5 ! sample 0 fir/ obta9$1 ?is feature 0 n obs]v$4 8,p>es9e10#agj accord+ to ! manufactures1 is a mixture compos$ ( p>aff91 #id to #if p] c5t42 gum elemi1 #j4bj to #j4be p] c5t42 ,japan wax1 #j4dj to #j4ej p] c5t42 asphalt1 #j4bj to #j4be p] c5t41 & eucalyptol1 #b p] c5t41 ! :ole be+ color$ ) alkann9 & g5tian violet4#aga #agj ,made by ! ,abbott ,laboratories1 ,*icago1 & accept$ by ! ,c\ncil on ,ph>macy & ,*emi/ry = ,new & ,non(ficial ,rem$ies1 ,! ,j\rnal1 ,may #ab1 #aiag1 p4 #adjf4 #aga ,no *emical exam9ation 0 made4 ,,=mula ,,= ,,p>aff9 ,,film ,9 a rec5t article1 ,sollmann#agb pres5t$ v>i\s sugge/ions = ! comp\nd+ ( p>aff9 films4 ,"s ( ! =mulas 7 promis+ & o!rs 7 n1 b all 7 simple4 ,he did n try to imitate 8,ambr9e40 ,lieut4-,col4 ,a4 ,j4 ,hull#agc ( ! ,royal ,army ,m$ical ,corps1 aft] exp]im5t+ ) diff]5t comb9ations1 conclud$ t a mixture ( 8#a "p resorc91 #b p>ts eucalyptus oil1 #e p>ts olive oil1 #be p>ts s(t p>aff9 petrolatum#agd & #fg p>ts h>d p>aff90 s]v$ ! purpose z well z 8,ambr9e40 ,! foll[+ =mula1 :i* might be call$ ,asphalt-,p>aff9 ,no4 #ba1 mu* m closely resembles 8,ambr9e10 & x seems to h c]ta9 advantages1 due to ! use ( a m suitable grade ( p>aff93 ,p>aff9#age 7,m4 ,p4 by ,u4 ,s4 ,p4 me?od #dg4b ,c47 #ig4e gm4 ,asphalt f #c to #e drops ,olive oil #a4e c4c4 #agb ,sollmann1 ,torald3 ,sugge/$ ,=mulas = ,p>aff9 ,films1 ,! ,j\rnal ,a4 ,m4 ,a41 ,april #g1 #aiag1 p4 #ajcg4 #agc ,hull1 ,a4 ,j43 ,! ,treatm5t ( ,burns by ,p>aff91 ,brit ,m$4 ,j\r41 ,jan4 #ac1 #aiag1 p4 #cg2 ,! ,treatm5t ( ,burns by ,p>aff91 ,!rapeutics1 ,! ,j\rnal ,a4 ,m4 ,a41 ,feb4 #c1 #aiag1 p4 #cgc4 #agd ,! 8s(t p>aff90 ( ! ,briti% ,ph>macopeia resembles petrolatum1 ,u4 ,s4 ,p41 ,qu]ies & ,m9or ,notes1 ,! ,j\rnal ,a4 ,m4 ,a41 ,april #bh1 #aiag1 p4 #abha4 #age ,! p>aff9 us$ 9 ?is =mula 0 suppli$ by ! ,/&>d ,oil ,company ( ,indiana2 ! melt+ po9t giv5 by ! manufactur]s is f #abj to #abb ,f41 :i*1 accord+ to ! ,am]ican ,/&>d ( tak+ melt+ po9ts1 gives high] results ?an ! me?od describ$ 9 ! ph>macopeia4 ,illu/ration3 - - - - - - - - - - - - - - - - - inception4 ,:]e ! ,dry ,wax ,p\ltice has be5 us$ ,!rmoz9e kn[n 9 ,france z l',ambr9e1 has be5 us$ 9 ! foll[+ ,p>isian hospitals1 ) #ib ( cures3 ,hospital de la ,pitie1 s]vices ( ,drs4 ,lion1 ,d>i] - - - - - - - - - - - - - - - - - ,photographic reproduction f a booklet on 8,!rmoz9e0 %[+ t x is id5tical ) 8,ambr9e40 ,ab\t #aj c4c4 ( 8asphalt v>ni%0 7,b4 ,asphaltum7#agf is plac$ 9 a beak] & heat$ on ! /eam ba? = "o-half h\r4 ,f #c to #e drops1 deliv]$ f a #a c4c4 pipet1 are !n plac$ 9 a cass]ole1 & #a4e c4c4 ( olive oil add$4 ,! mixture is heat$ & /irr$ = a few m9utes until p]fect solution is effect$4 ,to ?is is !n add$1 ) /irr+1 ! p>aff91 :i* has be5 previ\sly melt$4 ,:5 x is cool$1 a br[n solid is obta9$4#agg ,! physical factors ( ?is p>aff9 mixture are1 melt+ po9t #de4d ,c4 7,u4 ,s4 ,p4 me?od72 pla/icity1 #bh4e2 ductility1 #bi2 x is v pliable & /rong at #ch ,c41 & adh]es exce$+ly well to ! sk91 al?\gh x deta*es easily4 ,?is mixture1 :i* is easy to prep>e1 is inexp5sive1 ! co/ ( ! mat]ials be+ approximately #aj c5ts a p\nd4 #agf ,! 8,asphalt ,v>ni%0 us$ 0 obta9$ f ,remi5 ,kuhn]t ,company1 ,*icago4 #agg ,:ile ne$less1 a color resembl+ 8,ambr9e0 may be obta9$ by ! addition ( color+ ag5ts4 ,bo? ,hull & ,sollmann notic$ t t>like sub/ances & melt$ p>aff9 d n mix well4 ,?is is noticeable 9 8,ambr9e10 :i* _c be call$ an 8elegant0 prep>ation4 ,! difficulty may be ov]come by fir/ mix+ hot olive oil & asphalt2 ! asphalt w !n g into solution4 ,x is int]e/+ to note t ! sugge/$ =mula 7z well z o!rs :i* 7 also prep>$7 is n z pla/ic z ! p>aff9 itself4#agh ,?is is also true ( 8,ambr9e40 ,on ! o!r h&1 ! melt+ po9t ( ! p>aff9 is high]4 ,! important po9t1 h[ev]1 9 comp\nd+ all p>aff9 prep>ations1 is to select a prop] grade ( p>aff9 z elaborat$ bel[4 #agh ,9 a p]sonal communication ,dr4 ,sollmann express$ ! op9ion t ! syn!tic prep>ation is inf]ior to ! p>aff9 us$ 9 ! =mula1 bas+ ! view on ! great] pla/icity ( ! p>aff94 ,= practical purposes1 ! p>aff9 w mo/ probably s]ve z well z ! mixture1 especially :5 x is held 9 place by b&ages1 b ,i believe t ! mixture is m adhesive4 ,,exam9ation ,,( ,,p>aff9s ,,& ,,p>aff9 ,,prep>ations ,illu/ration3 ,photographic reproduction 7greatly r$uc$7 ( a full page magaz9e adv]tisem5t ( 8,!rmoz9e10 ! "n "u :i* 8,ambr9e0 0 sold to ! public4 ,! "n 8p>aff90 g5]ally applies to a colorless & ta/eless waxlike sub/ance t is solid at ord9>y temp]ature4 ,x is compos$ ( saturat$ hydroc>bons1 t is1 !y are unable to take up any m hydrog51 & !reby are q /able2 ! hydroc>bons 9 p>aff9 h ! g5]al =mula ( ,cn,h#bn#b1 rang+ z high z ,c,h to ,c,h4 ,p>aff9 may be f\nd 9 crude =m 9 coal1 f :i* s\rce ! fir/ p>aff9 c&les 7 made4 ,x may be produc$ f ! di/illation ( br[n coal1 z 9 ,g]many1 or f bitum9\s %ale4 ,9 ,am]ica1 x is obta9$ *iefly f ! di/illation ( crude petroleum1 be+ 9 ! residue aft] ! di/illation ( su* products z naph?a 7gasol9e71 k]os5e & ! lubricat+ oils4 ,! residue is treat$ by "o ( a numb] ( processes caus+ ! unpurifi$ solid p>aff9 to be made available4 ,! crude p>aff9 is ei!r sold z su*1 or is ref9$4 ,p>aff9 or 8p>aff9 waxes0#agi are designat$ 9 ! trade by _! melt+ po9ts 7:i* 9 ! 8,am]ican /&>d0 is express$ 9 ,fahr5heit degrees71 & z to _! /ate ( ref9em5t z 8crude10 8semiref9$0 & 8fully ref9$0 p>aff94 ,!re are c]ta9 *emical & physical diff]5ces s t two ref9$ waxes hav+ ! same melt+ po9t w\ld n h ! same pla/icity4 ,! high] melt+ po9t v>ieties ( p>aff9 are h>d & t\gh at room temp]ature3 :5 melt$1 p>aff9 exp&s & =ms a ?9 mobile liquid4 #agi ,p>aff9 is sometimes spok5 ( z 8:ite wax40 ,?is is un=tunate1 z 8:ite wax0 is an (ficial "n = 8,:ite ,beeswax1 ,u4 ,s4 ,p40 ,! t]m 8:ite wax0 is also (t5 appli$ to 8,*9ese wax10 :i* is =m$ f an insect liv+ on ! tree ,ligu/rum lucidum4 ,illu/ration3 ,photographic reproduction f a booklet on 8,!rmoz9e0 giv+ ! conditions 9 :i* ! /uff 0 alleg$ to be 8v useful40 ,! significant requirem5ts ( p>aff9 = surgical dress+s are t x %\ld be solid at body temp]ature1 at ! same "t hav+ flexibility & adhesiv5ess1 toge!r ) a c]ta9 am\nt ( /r5g?4 ,a numb] ( br&s ( p>aff9 are sold 9 ! ,unit$ ,/ates1 s t x seem$ advisable to exam9e "s ( !m & comp>e !m ) c]ta9 p>aff9-film prep>ations4 ,!y 7 te/$ z to _! melt+ po9ts1 pla/icity1 ductility1 /r5g? ( film1 etc4 ,melt+ ,po9t ,det]m9ation4--,! melt+ po9t 0 det]m9$ by ! me?od ( ! ,u4 ,s4 ,ph>macopeia ,,ix1 p4 #eif4 ,! melt+ po9t z obta9$ by ?is me?od is l[] ?an ! melt+ po9t us$ by manufactur]s ( p>aff9 7aft] conv]sion to ,fahr5heit74 ,pliability & ,ductility1 ,limit ,temp]ature4#ahj--;,a little ( ! melt$ wax 0 p\r$ f a teaspoon on ! surface ( ! wat] at ab\t #dj ,c41 9 a t9 pan 7bread mold74 ,?is =m$ a fairly ?9 film4 ,! temp]ature ( ! wat] 0 !n l[]$ by ! addition ( cold wat]4 ,at ea* temp]ature ! pliability & ductility 7 te/$ ?us3 #ahj ,i am indebt$ to ,dr4 ,torald ,sollmann = ^! me?ods4 ,pliability ,te/4--,! film1 imm]s$ 9 wat]1 0 d\bl$ on itself1 note be+ tak5 :e!r or n x broke4 ,ductility ,te/4--,! film 0 pull$ "u wat]1 note be+ tak5 :e!r x /ret*$ on be+ pull$ & broke ) a ragg$ fracture2 or :e!r x broke %>p )\t /ret*+4 ,x is desirable t ! pliability & ductility be pres]v$ at z l[ a temp]ature z possible4 ,cotton ,films1 ,adhesives & ,deta*ability4#ahj--,! melt$ wax 0 appli$ z x w\ld be = burns2 namely1 a ?9 lay] 0 pa9t$ on ! inn] surface ( ! =e>m ) a camel's hair bru%1#aha a transv]se /rip ab\t an in* wide be+ made4 ,?is 0 cov]$ ) a v ?9 lay] ( absorb5t cotton1 & ov] ?is ano!r lay] ( melt$ wax 0 pa9t$4 ,z soon z ?is _h cool$ a little1 x 0 cov]$ by a few lay]s ( b&age & left on = at lea/ an h\r4 ,at ! end ( t "t1 ! b&age 0 remov$4 ,! cotton film %\ld be f\nd at ! place at :i* x 0 appli$1 %[+ t x is suffici5tly adh]5t4 ,x %\ld deta* )\t 8pull+0 ! sk94 #aha ,:5 pa9t+ a surface ) a p>aff9 film1 ,i f\nd t ! temp]ature ( ! p>aff9 %\ld n be too close to ! melt+ po9t1 b sev]al degrees above2 o!rwise x does n 8set0 well4 ,illu/ration3 ,photographic reproduction 7greatly r$uc$7 ( ! c>ton 9 :i* 8,ambr9e0 is n[ sold4 ,! results ( ^! te/s are giv5 9 ! accompany+ table4 ,x c be se5 t ne>ly all ! p>aff9s exam9$ h prop]ties :i* w\ld make !m useful1 ! notable exceptions be+ ,nos4 #h1 #ae & #af4 ,! m satisfactory products w\ld be ^? hav+ a melt+ po9t ab\t #dg ,c41 ductility ( #cj or bel[1 & pla/icity ( #bh or bel[4 ,! p>aff9 describ$ 9 ! ,u4 ,s4 ,ph>macopeia is n s satisfactory1 ! requir$ melt+ po9t be+ betwe5 #ej & #eg ,c4 ,! use ( p>aff9 b&ages has be5 sugge/$ by ,fi%]#ahb & ,sollmann4#ahc ,9 su* cases1 x may v likely be t a p>aff9 ( high] melt+ po9t w\ld be m satisfactory1 ow+ to its great] resi/ance & t\gh] fib]4 #ahb ,fi%]1 ,h4 ,e43 ,nonadh]+ ,surgical ,gauze1 ,! ,j\rnal ,a4 ,m4 ,a41 ,m>* #be1 #aiaf1 p4 #ici4 #ahc ,sollmann1 ,torald3 ,p>aff9-,cov]$ ,b&ages1 ,! ,j\rnal ,a4 ,m4 ,a41 ,april #ba1 #aiag1 p4 #aagh4 ,,summ>y #a4 8,ambr9e0 is ess5tially p>aff9 9 :i* a small am\nt ( fatty & asphalt-l body is incorporat$2 l mo/ secret mixtures1 its composition v>ies4 #b4 ,a simple =mula = a p>aff9 film1 simil> 9 *emical composition b sup]ior 9 physical prop]ties to 8,ambr9e10 is t describ$ z ,=mula #ba4 ,! sup]iority is due to us+ a grade ( p>aff9 t is bett] adapt$ to ! purpose4 ,! co/ ( mat]ials is ab\t #aj c5ts a p\nd4 #c4 ,! prop]ties ( ! p>aff9 us$ = a surgical dress+ are important4 ,a numb] ( diff]5t grades h be5 exam9$1 9 ord] to det]m9e ! ones t appe> mo/ promis+4 ,p>aff9s ,nos4 #c1 #d1 #aj1 #aa & #be are ! be/ 9 ! table1 & surpass 8,ambr9e0 itself4 #d4 ,x is exce$+ly probable t fur!r exp]i5ce w %[ t = mo/ purposes simple p>aff9 w s]ve j z well z ! mixtures--if1 inde$1 n bett]4 ,add5da 7,repr9t$ f ! ,annual ,report ( ! ,*emical ,laboratory ( ,! ,am]ican ,m$ical ,association1 ,vol4 #aj 7#aiag71 p4 #cb7 ,s9ce ! =ego+ 0 publi%$1 two o!r products--8,c]el5e0 & 8,/anol9d ,surgical ,wax0--7 submitt$ to ! ,c\ncil on ,ph>macy & ,*emi/ry = inve/igation z to _! acceptability = inclusion 9 ,new & ,non(ficial ,rem$ies4 ,9 ?is connection ! ,laboratory 0 reque/$ to exam9e !m4 8,c]el5e0 is manufactur$ by ! ,holliday ,laboratories1 ,pittsburgh4 ,accord+ to ! manufactur]s1 8,c]el5e0 is a comp\nd compos$ ( #hd p] c5t4 p>aff91 #ae p] c5t4 myricyl palmitate & #a p] c5t4 elemi gum4 ,z ord9>ily m>ket$1 8,c]el5e0 conta9s ! foll[+ mat]ials3 ,to ! beeswax is add$ ,oil ( ,eucalyptus1 ,u4 ,s4 ,p41 #b p] c5t41 & ,betanaph?ol1 ,u4 ,s4 ,p41 #j4be p] c5t4 ,! manufactur] fur!r /ates t ! myricyl palmitate is a purifi$ =m ( beeswax1 free f all impurities1 acids1 etc41 :i* is solely manufactur$ by ?is company & = :i* pat5ts are p5d+4 ,! prop]ties describ$ = 8,c]el5e0 7 z foll[s3 ,:5 cold1 ,c]el5e is a solid wax-l cake ( a f9e yell[ br[n color4 ,on exposure to air = long p]iods1 ! amb] color d>k5s to "s ext5t4 ,x is entirely free f solids1 odorless & ta/eless2 does n sep>ate or *ange :5 melt$ repeat$ly1 & _c 9 ! melt$ /ate be sep>at$ by fractional cry/allization4 ,x is entirely neutral to indicators be+ p]fectly free f bo? acids & bases4 ,te/s3 ,melt+ ,po9t1 ,u4 ,s4 ,p4 me?od1 #abf ,f4 ,d5sity1 ,u4 ,s4 ,p4 me?od1 #j4ijg4 ,iod9 value1 #j4e4 ,saponification numb]1 #j4i4 8,/anol9d ,surgical ,wax0 is manufactur$ by ! ,/&>d ,oil ,company ( ,indiana4 ,9 ! submission ( ! product to ! ,c\ncil on ,ph>macy & ,*emi/ry1 x 0 /at$ t ! product 0 a specially prep>$ p>aff9 8free f dirt or o!r delet]i\s matt]4444 ,x has be5 /eam$ & re/eam$ to drive out any free oil & repeat$ly filt]$40 ,! exam9ation ( ! =ego+ products yield$ ! figures describ$ 9 ,table 8,b40--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,may #ai1 #aiag47 ,,! ,,/ability ,,( ,,iod9e ,,o9tm5ts ,l4 ,e4 ,w>r51 ,ph4,c41 ,b4,s4 ,9 g5]al1 ! lit]ature on ! keep+ qualities ( iod9e o9tm5t1 & on ! /ability ( iod9e if mix$ ) o9tm5t bases1 is confus+4 ,! record$ evid5ce is (t5 contradictory4 ,! att5tion ( ! writ] 0 br\ght to ?is condition by /udies ( sev]al propriet>y prep>ations1 ,iodex1#ahd ,iod-,izd-,oil1#ahe ,iocamf51 & ,iocamf5 ,o9tm5t4#ahf #ahd ,rep4 ,*em4 ,lab41 ,a4 ,m4 ,a41 #aiae1 #h1 #hi4 #ahe ,rep4 ,*em4 ,lab41 ,a4 ,m4 ,a41 #aiae1 #h1 #ajf4 #ahf ,rep4 ,*em4 ,lab41 ,a4 ,m4 ,a41 #aiaf1 #i1 #aah4 ,iodex 0 sold "u ! claim t x is 8444 an embodim5t ( vaporiz$ iod9e1 9 an organic base1 r$uc$ & /&>diz$ at #e p] c5t4 by incorporation ) a ref9$ petroleum product40 ,! exact composition ( ,iodex is a trade secret4 ,analysis %[$ t x conta9s petrolatum-l sub/ances & comb9$ iod9e1 ! latt] probably 9 comb9ation ) oleic acid4 ,te/s = free iod9e 7 made 9 five specim5s ( ,iodex4 ,9 "o ( ^! no free iod9e 0 pres5t2 9 ! o!rs ! m]e/ traces 7 f\nd4 ,two ye>s ago a prep>ation call$ 8,iod-,izd-,oil0 0 exam9$4 ,?is 0 claim$ to conta9 #b p] c5t4 ( free iod9e 9 liquid petrolatum4 ,at ! "t ( ! exam9ation ! age ( ! prep>ation 0 n kn[n1 b x _h be5 obta9$ j prior to ! analysis1 & 0 ?\ght n to be v old4 ,! analysis %[$ t x conta9$ b ab\t #j4dc p] c5t4 ( iod9e1 all ( :i* 0 9 a free /ate4 ,! fact t all ( ! iod9e pres5t 0 9 ! free /ate appe>$ to indicate t iod9e is relatively /able 9 liquid petrolatum solutions4 ,iocamf5 is a liquid compos$ ( iod9e1 camphor & ph5ol4 ,x 0 claim$ to conta9 #aj p] c5t4 ( free iod9e4 ,analysis %[$ t x conta9$ #i4c p] c5t4 ( total iod9e 7( :i* #g4e p] c5t4 0 pres5t 9 an uncomb9$ /ate71 #ff4a p] c5t4 ( camphor & #ai4g p] c5t4 ( ph5ol4 ,aft] /or+ = sev]al mon?s a second assay ( ,iocamf5 %[$ no appreciable loss 9 iod9e cont5t4 ,?is w\ld indicate t iod9e is relatively /able 9 pres5ce ( ph5ol & camphor1 al?\gh imm$iately aft] mix+ !re is "s loss ( free iod9e4 ,! ,iocamf5 ,o9tm5t 0 suppos$ to conta9 #ej p] c5t4 ( ,iocamf5 7equival5t to #e p] c5t4 ( free iod9e7 9 a l>d-wax-cacaobutt] base4 ,! analysis %[$ t ! o9tm5t conta9$ b #j4d p] c5t4 ( free iod9e1 ! balance be+ 9 comb9ation4 ,f ! results ( ! exam9ation1 & f correspond5ce ) ! manufactur]s 7,s*]+ & ,glatz71 x became evid5t t ! only plausible explanation = ! loss ( free iod9e 9 ! prep>ation ( ,iocamf5 ,o9tm5t f ,iocamf5 lay 9 ! comb9ation ( ! free iod9e ) ! +r$i5ts ( ! o9tm5t base4 ,x seems likely t ! free iod9e orig9ally pres5t 9 ,iocamf5 = ! mo/ "p _h gradually gone into comb9ation ) ! fatty sub/ances aft] ! o9tm5t _h be5 prep>$4 ,! lit]ature 0 !n exam9$ to det]m9e ! cons5sus ( op9ion conc]n+ ! /ability ( iod9e 9 iod9e o9tm5t4 ,9 ! old] lit]ature ! belief t iod9e o9tm5t is un/able appe>s to be q g5]al4 ,su* /atem5ts z ! foll[+ are typical3 ,! o9tm5t %\ld be prep>$ only :5 want$ = use1 = x und]goes *ange if kept1 los+ its deep1 orange-br[n color1 & becom+ pale ^u its surface4#ahg #ahg ,u4 ,s4 ,disp41 ed4 #ai1 p4 #acae4 ,x is bett] to prep>e x only z x is requir$ = use4#ahh #ahh ,am4 ,disp41 ed4 #b1 p4 #bjbb4 ,?is o9tm5t mu/ n be disp5s$ unless x has rec5tly be5 prep>$4#ahi #ahi ,u4 ,s4 ,ph>macopeia1 ,,ix1 p4 #dha4 ,9 #aiji ,ly?goe1#aij ( ! ,massa*usetts ,bo>d ( ,heal? laboratory1 report$ an exam9ation ( f\r samples ( iod9e o9tm5t4 ,?ree 7 f\nd to be pure1 ! f\r? 0 l[ 9 iod9e4 ,exp]im5ts %[$ t iod9e o9tm5t det]iorates rapidly2 consequ5tly1 no fur!r collections ( samples 7 made4 #aij ,rep4 ,mass4 ,bd4 ,heal?1 #aiji1 #da1 #dgg4 ,9 #aiab ,pull5#aia report$ t he _h prep>$ two specim5s ( iod9e o9tm5t accord+ to ! ,briti% ,ph>macopeia1 "o be+ f new l>d & ! o!r f a specim5 ( l>d at lea/ #b ye>s old4 ,assays = free iod9e 7 c>ri$ out imm$iately aft] ! prep>ations 7 made1 & at int]vals aft]w>d up to f\r mon?s4 ,! foll[+ values 7 f\nd3 #aia ,ph>m4 ,j\r41 #aiab1 #hi1 #faj4 ,sample ,i ,sample ,,ii ,o9tm5t f ,o9tm5t f new l>d1 old l>d1 p] c5t4 p] c5t4 ,iod9e introduc$ #d4j #d4j ,iod9e f\nd imm$iately aft] mak+ #c4ie #c4ch ,iod9e f\nd aft] tw5ty-f\r h\rs #c4cj #c4ae ,iod9e f\nd on ! ?ird day #c4ah #b4fb ,iod9e f\nd on ! sev5? day #c4ae #b4df ,iod9e f\nd on ! f\rte5? day #c4jj #b4de ,iod9e f\nd aft] "o mon? #c4jj #b4ci ,iod9e f\nd aft] two mon?s #b4ij #b4ca ,iod9e f\nd aft] f\r mon?s #b4ib #b4bf ,pull5 f\nd t ! loss 9 free iod9e c\ld be acc\nt$ = by ! iod9e :i* _h gone into comb9ation ) ! fats ( ! o9tm5t base4 ,pull5 also f\nd t if ! potassium iodide & glyc]9 7 omitt$ 9 ! prep>ation ( ! o9tm5t1 ! loss 9 free iod9e 0 v rapid1 ! prep>ation conta9+ practically no free iod9e 7only #a_/bj7 aft] a few h\rs4 ,he concludes t ! use ( potassium iodide & glyc]9 is necess>y = ! pres]vation ( ! o9tm5t4 ,he obta9$ specim5s ( iod9e o9tm5t 9 drug /ores1 & assay$ !m = free iod9e4 ,x is to be presum$ t ! ages ( ! sev]al specim5s 7 n kn[n4 ,! results are f\nd 9 ! foll[+ table3 ,specim5 ,no4 #a #b4gd p] c5t4 ,specim5 ,no4 #b #b4he p] c5t4 ,specim5 ,no4 #c #b4fb p] c5t4 ,specim5 ,no4 #d #b4dh p] c5t4 ,specim5 ,no4 #e #b4ec p] c5t4 ,specim5 ,no4 #f #b4gi p] c5t4 ,fri$#aib prep>$ iod9e o9tm5t accord+ to ! ,u4 ,s4 ,p4 ,,viii =mula1 & assay$ x at int]vals4 ,8 results are tabulat$ h]e)3 #aib ,ph>m4 ,j\r41 #aiab1 #hi1 #faj4 ,p] c5t4 ,iod9e introduc$ #d4jj ,iod9e f\nd imm$iately aft] mak+ #c4hi ,iod9e f\nd "o h\r aft] mak+ #c4ea ,iod9e f\nd "o day aft] mak+ #c4dh ,iod9e f\nd five days aft] mak+ #c4jf ,iod9e f\nd t5 days aft] mak+ #b4hd ,iod9e f\nd ?irty days aft] mak+ #b4ha ,iod9e f\nd n9ety days aft] mak+ #b4ha ,iod9e f\nd eight mon?s aft] mak+ #b4ha ,iod9e o9tm5t has be5 (ficial 9 ! ,u4 ,s4 ,ph>macopeia s9ce #ahgj4 ,briefly1 ! me?od n[ us$ = mak+ ! prep>ation is z foll[s3 ,f\r gm4 ( iod9e1 #d gm4 ( potassium iodide & #ab gm4 ( glyc]9 are weigh$ into a t>$ mort> & ! mixture triturat$ until ! iod9e & potassium iodide are dissolv$ & a d>k1 r$di%-br[n1 syrupy liquid is produc$4 ,eighty gm4 ( b5zo9at$ l>d are !n add$ 9 small portions & ) trituration aft] ea* addition4 ,! mass is !n triturat$ until ( uni=m consi/5ce4#aic #aic ,! "t requir$ to complete ! process aft] ! initial portion ( l>d has be5 add$ %\ld be ab\t tw5ty m9utes4 ,,p>aff9s ,,& ,,p>aff9 ,,prep>ations--,,table ,a ,,key3 ,a3 ,=mula ,b3 ,sub/ance ,c3 ,melt+ ,po9t1 ,u4 ,s4 ,p4 ,d3 ,ductility ,limit ,e3 ,pla/icity ,limit ,f3 7a7 ,adhesiv5ess & ,deta*ability 7b7 ,/r5g? ( ,film at #ch ,c4 ,a ,b ,c ,d ,e ,f #a 8,p>[ax10 #ej4h #cb4e #bi4j 7a7 ,adh]es & ,/&4 ,oil ,co4 ( ,ind4 deta*es well2 r h>d 7b7 ,pliable & /rong #c 8,p>aff9 #aah-abj ,f410 #df4h #bh4e #bd4e 7a7 ,does n adh]e ,/&4 ,oil ,co4 ( ,ind4 well2 deta*es easily 7b7 ,pliable b n /rong #d 8,p>aff9 #abj-abb ,f410 #dg4b #bi4j #bd4e 7a7 ,adh]es well2 ,/&4 ,oil ,co4 ( ,ind4 deta*es well 7b7 ,pliable & fairly /rong #e 8,p>aff9 #abc-abe ,f410 #dh4h #ca4e #bh4e ,same z #d ,/&4 ,oil ,co4 ( ,ind4 #f 8,p>aff9 #abh-acj ,f410 #eb4j #cc4j #cj4j 7a7 ,adh]es well2 ,/&4 ,oil ,co4 ( ,ind4 deta*es n s easily 7b7 ,pliable & /rong #g 8,texwax10 ,texas ,co41 #ea4b #cb4e #bi4h ,same z #f ,port ,ar?ur1 ,texas #h 8,p>aff9 ,wax #abb-abd ,f410 #ej4f #cf4j #cd-ce 7a7 ,unsatisfactory2 ,w>r5 ,ref9+ ,co41 does n adh]e ,w>r51 ,pa4 7b7 ,only slightly pliable2 too t\gh #i 8,p>aff9 ,no4 #iaj10 #dg4j #cj4e #bf-bg 7a7 ,adh]es well2 ,wav]ly ,oil ,works1 deta*es well ,pittsburgh 7b7 ,pliable & /rong #aj 8,p>aff9 ,no4 #ibj10 #dd4d #bg4e #be4j 7a7 ,adh]es well2 ,wav]ly ,oil ,works1 deta*es well ,pittsburgh 7b7 ,pliable & fairly /rong #aa 8,h>d ,p>aff910 #dh4j #bh4e #bd4e-be4e 7a7 ,adh]es well2 ,rob't ,/ev5son ,co41 deta*es well ,*icago 7b7 ,pliable & /rong #ab 8,p>aff910 #dg4b #cc4j #cb4e ,n q z good ,isl& ,petroleum ,co41 z #aa ,*icago #ac 8,p>aff9 #abb ,f410 #df4h #cj4e #bg4e-bh 7a7 ,does n adh]e ,gulf ,ref9+ ,co41 s well2 ,pittsburgh deta*es well 7b7 ,v pliable #ad 8,p>aff9 #abe ,f410 #ej4j #cb4j #ca4j ,ab\t z #ac ,gulf ,ref9+ ,co41 ,pittsburgh #ae 8,p>aff9 #acb ,f410 #ed4h #ce4e #cd4j 7a7 ,does n adh]e ,gulf ,ref9+ ,co41 well ,pittsburgh 7b7 ,n v pliable1 b /rong #af 8,p>aff9 ,no4 #cja10 #ej4b #cc4j #cb-cb4e 7a7 ,does n adh]e ,national ,ref9+ ,co41 well ,clevel& 7b7 ,n v pliable #ah ,p>aff9 recov]$ #dh4f #cj4e #bh-bh4e 7a7 ,adh]es well2 f 8,ambr9e0 deta*es well 7b7 ,pliable b n /rong #ai 8,hyp]!rm9e0 #di4d #cc4e #cj4e-ca 7a7 ,does n adh]e well2 deta*es well 7b7 ,v pliable & /rong #bj 8,ambr9e0 #dh4d #cj4e #bg4j 7a7 ,adh]es well2 deta*es well 7b7 ,v pliable & /rong #ba ,p>aff9 #abj-abb ,f4 #de4d #bi4j #bh4e 7a7 ,adh]es 7see #c71 #ig4e2 excell5tly2 olive oil1 #a4e2 deta*es well asphalt1 #d drops 7b7 ,v pliable & /rong #bb 8,p>[ax0 7see #a71 #ig4e2 #di4b #cb4j #cj4e 7a7 ,adh]es well2 olive oil1 #a4e2 deta*es well asphalt1 #d drops 7b7 ,pliable & /rong #bc 8,mul5e0 #ea4j #cf4j #bh4j 7a7 ,adh]es b deta*es ) difficulty 7b7 ,pliable b n /rong #bd 8,p>res9e10 #df4j #bi4e #bf4j 7a7 ,adh]es well2 ,abbott ,laboratories1 deta*es easily 7b7 ,pliable & fairly /rong #be 8,p>aff9 #aah-aba ,f410 #de4h #bf4d #bc4b 7a7 ,adh]es well2 ,! ,atlantic ,ref9+ deta*es easily ,co41 ,philadelphia 7b7 ,pliable & ,*icago fairly /rong ,,table ,b #bf 8,c]el5e10 #ej4j #cj4e #bf4e 7a7 ,adh]es well2 ,holliday ,lab4199 deta*es ) ,pittsburgh pull+ 7b7 ,n /rong at #ch ,c4 #bg 8,/anol9d0 ,surgical #dg4j #bh4h #be4j 7a7 ,adh]es well2 ,wax1 ,/&>d deta*es easily ,oil ,co4 ( ,ind4 7b7 ,fairly /rong at #ch ,c4 99 ,on be+ heat$1 x readily loses eucalyptol1 & a small am\nt ( res9\s sub/ance =ms 9 ! bottom ( ! beak]4 ,if 8,c]el5e0 is heat$ to #ade ,c4 & cool$1 ! result+ product no long] has ! prop]ties ( ! orig9al 8,c]el5e40 ,accept$ by ! ,c\ncil on ,ph>macy & ,*emi/ry = inclusion 9 ,new & ,non(ficial ,rem$ies4 ,iod9e o9tm5t is (ficializ$ also 9 sev]al =eign ph>macopeias1 al?\gh ! iod9e /r5g? ( ! sev]al prep>ations is n uni=m4 ,! =mula 9 ! ,briti% ,ph>macopeia is exactly l t 9 ! ,u4 ,s4 ,ph>macopeia except t pure l>d is direct$ to be us$ in/ead ( b5zo9at$ l>d4 ,"s ( ! =eign ph>macopeias also specify t ! prep>ation mu/ be fre%ly prep>$ :5 want$4 ,9 ! e>li] editions ! ,u4 ,s4 ,ph>macopeia direct$ ! o9tm5t to be prep>$ by us+ wat] z ! solv5t = ! potassium iodide4 ,9 ! ,u4 ,s4 ,ph>macopeia ,,viii ! =mula 0 *ang$ s z to employ glyc]91 & t solv5t is n[ (ficial4 ,wat] is /ill prescrib$ z ! potassium iodide solv5t by ! ,ph>macopeias ( ! ,ne!rl&s & ( ,france4 ,f ! exam9ation ( ! lit]ature x seems probable t iod9e o9tm5ts :i* conta9 petrolatum products only z ! o9tm5t bases are apt to be relatively /able1 s f> z ! cont5t ( free iod9e is conc]n$4 ,on ! o!r h&1 o9tm5ts ! bases ( :i* conta9 fats ( ! unsaturat$ fatty acid s]ies1 su* z oleic acid1 d n satisfactorily pres]ve ! iod9e 9 ! free /ate4 ,9 ! latt] class x seems likely t ! iod9e ent]s into comb9ation ) ! unsaturat$ fatty acids4 ,accord+ly1 on !oretical gr\nds1 an o9tm5t base compos$ ( pure /e>9 7if su* sub/ance 7 available7 b s(t5$ by an admixture ( liquid petrolatum w\ld pres]ve ! iod9e satisfactorily4 ,cocoanut oil 7iod9e ,no4 #h7 ought to be suitable also if mix$ ) h>d p>aff94 ,s9ce ! lit]ature 0 n suffici5tly concordant to w>rant positive conclusions conc]n+ ! /ability ( o9tm5ts conta9+ free iod9e1 x seem$ wor? :ile to conduct exp]im5ts ) prep>ations ( kn[n orig94 ,accord+ly1 a numb] ( prep>ations conta9+ free iod9e 7 made "u v>y+ conditions & ea* 0 assay$ = its free iod9e cont5t imm$iately aft] its manufacture & f "t to "t lat]4 ,leaf l>d ( ! be/ quality obta9able 0 pur*as$ f a but*]4 ,?is 0 r5d]$ 9 an op5 di% on ! /eam ba?4 ,! prep>ation 0 ( a f9e color1 & uni=m consi/5ce & _h a fa9t b n unpleasant odor4 ,two specim5s ( l>d 7 furni%$ by ! rese>* dep>tm5t ( ,arm\r & ,company4 ,an ef=t 0 made to procure specim5s ( l>d hav+ iod9e absorption numb]s z f> ap>t z possible1 i4 e41 "o ) a l[ & ! o!r ) a high iod9e value4 ,?is 0 done 9 ord] to det]m9e :e!r ! keep+ qualities ( ! o9tm5ts prep>$ f ! two w\ld be alike4 ,"o ( ! specim5s 7a7 0 describ$ z 8,natural l>d2 iod9e value1 #eg4a4 ,leaf l>d us$ exclusively = butt]9e & b5zo9at$ l>d40 ,! o!r specim5 0 describ$ z 8,prime /eam l>d4 ,good1 comm]cial grade ( l>d = g5]al use2 iod9e value1 #fi4j40 ,! iod9e absorption numb]s ( ! ?ree specim5s 7 det]m9$ by ! ,u4 ,s4 ,p4 process to be z foll[s3 ,laboratory r5d]$ specim5 #eg4a ,arm\r specim5 7a7 #eg4fe ,arm\r specim5 7b7 #fg4ee ,ea* specim5 0 b5zo9at$ accord+ to ! process describ$ 9 ! ,u4 ,s4 ,p4 ,,ix & #ajj gm4 ( iod9e o9tm5t 7 prep>$ f ea* accord+ to ! ,u4 ,s4 ,p4 process4 ,ano!r specim5 0 made f b5zo9at$ l>d & iod9e only#aid )\t ! addition ( ei!r glyc]9 or potassium iodide4 ,?is 0 made to conta9 #d p] c5t4 ( iod9e4 #aid ,9 ord] to facilitate ! incorporation ( ! iod9e ) ! fatty base ! iod9e 0 fir/ p[d]$ by trituration ) alcohol & dry+ ! p[d] 9 ! air4 ,imm$iately aft] prep>ation ea* ( ^! iod9e o9tm5ts 0 assay$ = free iod9e1 & ea* 0 reassay$ at int]vals lat]4 ,! me?od = ! det]m9ation ( iod9e 9 ! o9tm5t 0 t employ$ 9 ?is laboratory = ! det]m9ation ( iod9e 9 ,iocamf5 ,o9tm5t4#aie ,x is ess5tially ! same z 0 employ$ by ,pull5 = ! det]m9ation ( uncomb9$ iod9e 9 iod9e o9tm5t4#aif ,z c>ri$ out 9 ?is laboratory = iod9e o9tm5t x is z foll[s3 #aie ,rep4 ,*em4 ,lab41 ,a4 ,m4 ,a41 #aiaf1 #i1 #aah4 #aif ,ph>m4 ,j\r41 #aiab1 #hi1 #faj4 ,f #e to #h gm4 ( ! o9tm5t 7 weigh$ 9 a small porcela9 capsule1 ! capsule & cont5ts plac$ 9 a #af oz4 salt m\? bottle toge!r ) #bj c4c4 ( *lor(orm1 #aj c4c4 ( potassium iodide solution & #dj c4c4 ( wat]4 ,t5?-normal sodium ?iosulphate 0 sl[ly add$ ) agitation until ! p9k color ( ! *lor(orm lay] _h ne>ly disappe>$4 ,a little soluble />* 0 !n add$ & ! titration cont9u$ until a blue color 9 ! aque\s lay] c\ld no long] be obta9$ by repeat$ %ak+4 ,! f9d+s = ! sev]al assays are tabulat$ h]e)3 ,u4 ,s4 ,p4 ,u4 ,s4 ,p4 ,u4 ,s4 ,p4 ,o9tm5t ,o9tm5t ,o9tm5t ,o9tm5t f ,age at f f f l>d & "t laboratory comm]cial comm]cial iod9e only ( r5d]$ l>d l>d 7laboratory assay l>d ,grade ,i ,grade ,,ii r5d]$ l>d7 7 ,i7 7 ,i7 7 ,i7 7 ,i7 ,fre%ly made #c4cb #c4bf #c4cj #j4cb ,aft] #c days #c4be 4444 4444 #j4bc ,aft] #g days #b4ii #c4ag #c4ae 4444 ,aft] #c weeks #c4ja #c4ai #c4jg 4444 ,aft] #g weeks #c4ab99 #c4aj #c4jb 4444 ,aft] #c mon?s #b4ih #b4hh #b4hh 4444 99 ,?is slight rise 9 iod9e cont5t foll[$ by a fall c\ld n be acc\nt$ =4 ,! specim5 0 believ$ to h be5 v ?or\ghly mix$ at ! "t ( manufacture4 ,t ! fatty con/itu5ts ( ! o9tm5t conta9$ iod9e aft] ! prep>ation _h be5 made = "s "t 0 demon/rat$4 ,"s ( ! mat]ial 0 exam9$ z foll[s3 ,a portion ( ! o9tm5t :i* _h be5 made = ne>ly ?ree mon?s 0 %ak5 9 a sep>ator ) *lor(orm & a dilute mixture ( potassium iodide & sodium ?iosulphate solutions4 ,aft] all ( ! free iod9e _h be5 remov$ ! *lor(ormic solution ( ! fats 0 wa%$ sev]al times ) a v dilute solution ( sodium ?iosulphate4 ,! *lor(ormic solution 0 filt]$1 evaporat$ & ! residue dri$ ov] sulphuric acid4#aig #aig ,! resultant fatty residue 0 ( a br[ni%-gre5 color4 ,x no long] _h ei!r ! ta/e1 color or odor ( l>d4 ,x 0 not$ t ! fats1 aft] removal by ?is me?od f ! fre%ly prep>$ o9tm5t1 7 ne>ly :ite4 ,z ! o9tm5t ag$ ! fat became successively d>k] 9 color4 ,! sep>at$ fat 0 !n te/$ = iod9e by ,k5dall's me?od4#aih ,x 0 f\nd to conta9 iod9e 9 consid]able am\nts1 b quantitative det]m9ations 7 n made4 #aih ,! me?od dep5ds ^u ! conv]sion ( all ( ! iod9e comp\nds into iodate by fusion ) sodium hydroxide & oxidation ) potassium nitrate4 ,! melt is dissolv$ 9 wat]1 a little sodium bisulphite add$1 ! solution cool$ & neutraliz$ ) phosphoric acid1 us+ me?yl orange z indicator4 ,an excess ( brom9e wat] is add$1 & ! mixture boil$ to expel c>bon dioxid & brom9e4 ,a little sodium salicylate is add$1 ! solution cool$1 an excess ( potassium iodid add$1 & ! lib]at$ iod9e titrat$ ) t5?-normal sodium ?iosulphate 9 ! usual way4 ,"o six? ( ! iod9e f\nd is obta9$ f ! mat]ial assay$1 ! balance be+ furni%$ by ! potassium iodide add$4--,j\r4 ,bio*em41 #aiad1 #ai1 #bea4 ,! ,ph>macopeia ( ! ,ne!rl&s directs t iod9e o9tm5t %all conta9 #c p] c5t4 ( potassium iodide & #b p] c5t4 ( iod9e in/ead ( equal proportions 7#d p] c5t4 ( ea*7 z prescrib$ by ! ,u4 ,s4 ,ph>macopeia4 ,likewise ! ,fr5* ,ph>macopeia directs t #aj p] c5t4 ( potassium iodide & only #b p] c5t4 ( iod9e %all be us$4 ,bo? ( ^! ph>macopeias use wat] in/ead ( glyc]9 z ! solv5t4 ,loose comb9ations ( iod9e & potassium iodide1 su* z are repres5t$ by ! comp\nd hav+ ! =mula ,,ki1 h be5 describ$4 ,! quantity ( potassium iodide prescrib$ by ! ,u4 ,s4 ,ph>macopeia = ! prep>ation ( iod9e o9tm5t is n suffici5t to =m su* a comp\nd z ,,ki ) all ( ! iod9e direct$ to be us$4 ,s9ce "s ( ! ph>macopeias use l>g] proportions ( potassium iodide 7m ?an suffici5t to =m ! comp\nd1 ,,ki71 x seem$ wor? :ile to det]m9e :e!r an o9tm5t conta9+ a great] proportion ( potassium iodide ?an t requir$ by ! ,u4 ,s4 ,ph>macopeia w\ld be m /able ?an ! (ficial article4 ,accord+ly a specim5 0 prep>$ to conta9 #d p] c5t4 ( iod9e1 #h p] c5t4 ( potassium iodide 7twice ! ,u4 ,s4 ,p4 requirem5t71 #ab p] c5t4 ( glyc]9 & #gf p] c5t4 ( l>d4 ,?is 0 assay$ = its free iod9e cont5t imm$iately aft] prep>ation1 & f\nd to conta9 #c4fh p] c5t4 ,n9e days lat] x conta9$ #c4gj p] c5t4 ,ano!r specim5 ( ! same iod9e /r5g? prep>$ f grade ,no4 #b ( comm]cial l>d assay$ #c4fi p] c5t4 at ! initial assay1 & sev5 days lat] #c4dj p] c5t4 ,f ^! exp]im5ts x seems likely t ! free iod9e cont5t ( ! ,u4 ,s4 ,ph>macopeia iod9e o9tm5t c\ld be rais$ some:at by increas+ ! proportion ( potassium iodide4 ,! results ( ^! /udies confirm ! f9d+s ( ,pull5 & ( ,fri$ 9 all ess5tial p>ticul>s4 ,x appe>s t dur+ ! process ( manufacture ( iod9e o9tm5t ab\t #bj p] c5t4 ( ! free iod9e goes into comb9ation ) ! fatty con/itu5ts ( ! o9tm5t4 ,on /&+ = a mon? approximately an additional #e p] c5t4 goes into comb9ation1 aft] :i* !re is practically no loss 9 free iod9e cont5t4 ,9 o!r words iod9e o9tm5t :i* is a mon? old is a relatively /able prep>ation4 ,x appe>s to make no noticeable diff]5ce ^u ! rate & am\nt ( iod9e absorption :e!r ! l>d f :i* ! o9tm5t is made has a high or a l[ iod9e absorption value4 ,! composition ( iod9e o9tm5t1 :i* has be5 made suffici5tly long to h rea*$ equilibrium1 is approximately z foll[s3 ,free iod9e #c p] c5t4 ,iod9e comb9$ ) fat #a p] c5t4 ,potassium iodide #d p] c5t4 ,b5zo9at$ l>d 7conta9+ iod9e7 #hj p] c5t4 ,! ,u4 ,s4 ,ph>macopeia requirem5t t iod9e o9tm5t %all be fre%ly prep>$ :5 want$ appe>s to be unnecess>y4 ,probably mo/ ph>maceutical manufactur]s are aw>e ( ?is1 = _m ( !m include ! prep>ation 9 _! trade li/s4 ,! pres5ce ( an iodide appe>s to be necess>y1 to prev5t practically all ( ! iod9e f ent]+ into comb9ation ) ! fat4#aii--7;,f ! ,am]ican ,j\rnal ( ,ph>macy1 ,augu/1 #aiag47 #aii ,9 ord] to det]m9e :e!r ! iod9e :i* is 9 comb9ation ) fat is absorb$ ?r\gh ! sk91 a few exp]im5ts 7 c>ri$ out4 ,! d>k-color$ iod9e-conta9+ fat 7obta9$ f ! o9tm5t & wa%$ free f potassium iodide by ! me?od describ$ above7 0 rubb$ ?or\ghly into ! sk9 ( ! =e>m4 ,x 0 all[$ to rema9 = f\r h\rs1 aft] :i* ! limb 0 sc\r$ ) soap suds4 ,beg9n+ at ! "t ( ! application ! ur9e 0 collect$ = =ty-eight h\rs4 ,?is 0 evaporat$ to small bulk & ! residue te/$ = iod9e by ,k5dall's me?od4 ,small am\nts ( iod9e 7 f\nd4 ,^! f9d+s 7 tak5 to indicate t ! iod9e-conta9+ fat is absorb$ to "s ext5t by ! sk94 ,x is g5]ally believ$ t potassium iodide is n absorb$ by ! unbrok5 sk94 ,!re=e x seems reasonable to suppose t ! pr9cipal iod9e effects obta9able f iod9e o9tm5t are ^? due to ! free iod9e conta9$ 9 ! prep>ation1 supplem5t$ to a slight ext5t by ! iod9e :i* is conta9$ 9 ! fatty o9tm5t base4--,j\r4 ,bio*em41 #aiad1 #ai1 #bea4 ,,iodol5e ,,& ,,! ,,solubility ,,( ,,iod9 ,,9 ,,liquid ,,petrolatum ,! ,c\ncil on ,ph>macy & ,*emi/ry 0 ask$ to exam9e a prep>ation submitt$ ) ! /atem5t t x 0 8iod9 cry/als incorporat$ 9 a petroleum product40 ,! "n 8,iodol5e0 0 propos$ by ! promot]s1 provid+ ! product 0 f\nd eligible = ,new & ,non(ficial ,rem$ies4 ,iodol5e 0 /at$ to h be5 prep>$ by treat+ a liquid petrolatum1 obta9$ f ,gulf ,coa/ petroleum1 ) an excess ( iod92 ! mixture 0 subsequ5tly 8plac$ 9 an ov5 = ?ree h\rs40 ,! claim 0 made t ?is me?od ( proc$ure produc$ a prep>ation conta9+ m iod9 ?an m>ket specim5s :i* _h be5 exam9$1 namely3 8ov] #a4ej p] c5t4 free iod9e40 ,two specim5s ( ! product 7 submitt$1 "o /at$ to h be5 unfilt]$1 & ! o!r filt]$4 ,bo? ( ! specim5s emitt$ a /rong odor ( hydrog5 sulphide ^u remov+ ! /opp] f ! respective conta9]s4 ,iod9 ,cont5t ( ,iodol5e4--,! iod9 cont5t ( ! filt]$ specim5 0 det]m9$ ?us3 ,a weigh$ am\nt--#c to #e gm4--0 transf]r$ to a sep>ator by means ( #bj c4c4 ( ligro91 us$ 9 portions4 ,tw5ty c4c4 ( #aj p] c5t4 potassium iodid solution 0 add$ & ! free iod9 titrat$ ) t5?-normal sodium ?iosulphate solution 7) agitation71 ! end po9t be+ ! abs5ce ( a yell[ color 9 ! aque\s lay]4 ,! am\nt ( free iod9 0 f\nd to be #a4cb p] c5t4 ,! ,solubility ( ,iod9 9 ,liquid ,petrolatum4--,to det]m9e ! solubility ( iod9 9 ,liquid ,petrolatum1 #bjj c4c4 ( ,liquid ,petrolatum-,squibb 7said to be compos$ ( hydroc>bons ( ! naph!ne s]ies7 & #bjj c4c4 ( ,/anol9d ,liquid ,p>aff9 7said to be compos$ *iefly ( m>% gas hydroc>bons7 7 ea* treat$ ) #e gm4 ( iod9 cry/als4 ,! two mixtures 7 ma9ta9$ = a week at a temp]ature some:at above t ( ! room & agitat$ occasionally4 ,ea* 0 !n cool$ to room temp]ature 7ab\t #bb ,c471 agitat$ = a day & !n filt]$4 ,! am\nt ( iod9 9 ! prep>ation made ) ,liquid ,petrolatum-,squibb 0 f\nd to be #a4db p] c5t4 ,! iod9 cont5t ( ! prep>ation made ) ,/anol9d ,liquid ,p>aff9 0 #a4cj p] c5t4 ,9 view ( ^! f9d+s ! prospective manufactur] 0 advis$ t ! ,c\ncil _c c\nt5ance a propriet>y "n = an un(ficial1 simple solution ( iod9 9 liquid petrolatum4--7,f ,reports ,a4 ,m4 ,a4 ,*emical ,laboratory1 #aiag1 p4 #hg47 ,,am]ican-,,made ,,syn!tic ,,drugs--,i ,exam9ation ( ,am]ican-,made ,acetylsalicylic ,acid ,paul ,ni*olas ,lee*1 ,ph4,d4 ,at ! reque/ ( ! ,c\ncil on ,ph>macy & ,*emi/ry1 ! ,a4 ,m4 ,a4 ,*emical ,laboratory has und]tak5 exam9ations ( ,am]ican-made syn!tic drugs4 ,! mo/ ext5sively us$ syn!tic is acetylsalicylic acid & h5ce an inve/igation ( ?is product 0 deem$ exp$i5t4 ,= sev5te5 ye>s acetylsalicylic acid 0 protect$ by a ,unit$ ,/ates ,pat5t 7! proprietors 7 n giv5 a pat5t 9 o!r c\ntries7 & sold "u ! "n 8,aspir940 ,9 ,febru>y1 #aiag1 ! pat5t expir$1 & s9ce !n a numb] ( firms h engag$ 9 ! manufacture ( acetylsalicylic acid1 sell+ x ei!r z su* or z aspir91 modifi$1 ( c\rse1 by a di/9ctive firm designation4 ,dur+ ?is p]iod ! =m] manufactur]s 7,! ,bay] ,co41 ,new ,york1 9 pa/ ye>s call$ ,f>b5fabrik5 ( ,elb]feld ,co41 ,new ,york7 h be5 ext5sively adv]tis+1 bo? to physicians & ! public1 ! alleg$ sup]ior qualities ( _! product4 ,! *emical exam9ation1 !re=e1 0 conc]n$ *iefly ) te/s ( purity1 & ! comp>ison ( ! ,am]ican br&s ) ! =m]ly pat5t$ product4 ,9 ,european c\ntries1 acetylsalicylic acid#bjj is describ$ 9 ! v>i\s ph>macopeias z a cond5sation product ( acetic anhydride or acetyl *loride ) salicylic acid 7o-hydroxyb5zoic acid74 ,g5]ally ! te/ ( id5tification is hydrolysis ( acetylsalicylic acid & qualitative te/s = acetic acid & salicylic acid4 ,= purposes ( purity ! requirem5ts are ess5tially t ! specim5 %\ld h a c]ta9 melt+ po9t1 %\ld %[ abs5ce ( salicylic acid by means ( f]ric *loride 7! manipulations = ! te/s are v>i\sly describ$7 & leave no appreciable a%4 ,! two te/s ( purity mo/ g5]ally employ$1 h[ev]1 are ! melt+ po9t & ! reaction ) f]ric *loride4 #bjj ,un=tunately1 ! nondescriptive "n 8aspir90 has be5 us$ ext5sively 9 ,european lit]ature & has ev5 got into ,european ph>macopeias1 in/ead ( ! sci5tific "n 8acetylsalicylic acid40 ,,melt+ ,,po9t ,! melt+ po9t ( acetylsalicylic acid has be5 giv5 at v>i\s temp]atures f #aah to #acg ,c4#bja2 ! ,briti% ,ph>macopeia describes ! melt+ po9t at #acc to #ace ,c42 ! ,g]man ,ph>macopeia 8ab\t #ace ,c420 ! ,fr5* ,ph>macopeia at #ace ,c42 ,new & ,non(ficial ,rem$ies1 #aiag1 #acd to #acf ,c4 ,! ,bay] ,company1 9 ! pat5t trial at ,*icago a numb] ( ye>s ago1 gave among ! 8f\r infallible te/s0 a melt+ po9t ( 8ab\t #ace ,c40 ,sev]al m5 h c>efully det]m9$ ! melt+ po9t 9 rec5t ye>s4 ,em]y & ,wright#bjb 9 #aiab f\nd t 8,aspir91 ,bay]0 melt$ at #acj4e to #aca ,c4 ,9 ,france1 ,franois#bjc has det]m9$ ! melt+ po9t ( pure acetylsalicylic acid1 :i*1 accord+ to 8 me?od1 is #acb ,c4 ,:5 v>i\s samples ( acetylsalicylic acid 7 exam9$ 9 ?is laboratory1 x 0 f\nd t ! melt+ po9t ( none 0 z high z t describ$ 9 ,new & ,non(ficial ,rem$ies or ! ,briti%1 ,fr5*1 or ,g]man ph>macopeias :5 tak5 accord+ to ! g5]al me?od ( ! ,u4 ,s4 ,ph>macopeia1 ,vol4 #i1 p4 #eif4 ,on critical obs]vation1 x may be se5 t ! melt+ po9t ( acetylsalicylic acid is prec$$ & accompani$ by decomposition4 ,if ! sample 9 ! melt+ tube is heat$ f ! orig9al room temp]ature ( ! ba? to #abj ,c41 ! temp]ature ( melt+ w be l[] ?an if ! ba? is fir/ heat$ to #abj ,c4 & ! melt+-po9t tube !n plac$ 9 ! ba?4#bjd ,?us ! melt+ po9t ( acetylsalicylic acid1 l s _m organic comp\nds :i* decompose & d n melt %>ply1 is unsatisfactory & _c be tak5 z an 8infallible te/0 ( purity1 especially :5 det]m9$ by diff]5t op]ators :o d n give _! me?od 9 detail4 ,aft] mak+ a l>ge numb] ( melt+-po9t det]m9ations ( acetylsalicylic acid1 alone & 9 p>allel ) o!r op]ators1 x 0 decid$ to use ! me?od describ$ 9 ! ,u4 ,s4 ,ph>macopeia modifi$ by fir/ heat+ ! ba? to #abj ,c4 be=e atta*+ ! melt+-po9t tube to ! !rmomet]4 #bja ,= ref]5ce to old] lit]ature see ,beil/e91 ,,ii1 #adif 7#hhi74 #bjb 8,! ,melt+ ,temp]ature ( ,aspir9 & ,salicylic ,acid ,mixtures10 ,proc4 ,assoc4 ,(f4 ,agr4 ,*em41 #aiab2 ,bureau ( ,*emi/ry1 ,dep>tm5t ( ,agriculture1 ,bull4 #afb4 #bjc 8,assay ( ,aspir910 ,j4 ,ph>m4 ,*em41 #ae 7#aag71 ,no4 #g1 #bac4 #bjd ,simil> obs]vations 7 made by ,em]y & ,wright1 :o /ate3 8,an accurate det]m9ation ( ! melt+ temp]ature 9 ?is way 7! rate ( heat+ 0 su* z to give a rise 9 temp]ature ( ab\t #a p] m9ute7 is r5d]$ difficult by ! fact t #8aspir9' decomposes on heat+1 z evid5c$ 9 ! depression ( ! melt+ temp]ature ( ! pure sub/ance ( ab\t #a = e five m9utes' heat+ j bel[ its melt+ temp]ature40 ,! melt+ po9t ( purifi$ acetylsalicylic acid 0 f\nd to be #aca4e to #acb4e ,c4 7corr474#bje ,) ! exception ( "o specim51 :i* 0 obvi\sly impure1 ! v>i\s specim5s exam9$ melt$ betwe5 #abh & #acc ,c4 z may be se5 9 ! accompany+ table4 ,x w\ld appe> t ?is range ( melt+ po9ts w\ld be m acceptable & reliable ?an ! melt+ po9ts describ$ 9 v>i\s /&>ds4 #bje ,isolat$ cry/als atta*$ to ! walls ( ! melt+-po9t tube1 ap>t f ! bulk acetylsalicylic acid1 melt$ at a l[] temp]ature4 ,,pres5ce ,,or ,,abs5ce ,,( ,,free ,,salicylic ,,acid ,x is g5]ally conc$$ t ! pres5ce ( salicylic acid 9 am\nts m ?an traces is delet]i\s4 ,fur!rmore1 ! am\nt ( salicylic acid is a good index ( ! purity ( ! acetylsalicylic acid1 because ! te/ is s delicate t1 "u favorable conditions1 m]e traces may be det]m9$ &1 z a rule1 ! bett] ! product1 ! less ! am\nt ( free salicylic acid4 ,! te/s appe>+ 9 v>i\s ph>macopeias = salicylic acid z an impurity 9 acetylsalicylic acid d n give concordant results1 diff]5t work]s int]pret+ ! results diff]5tly1 nor are !y detail$ 9 su* a mann] z to yield maximum delicacy4 ,aft] exp]im5tation1 x 0 decid$ to e/abli% a 8limit0 te/ ( approximately #j4a p] c5t4 free salicylic acid1 :5 c>ri$ out accord+ to ! foll[+ me?od3 #j4a gm4 ( ! sub/ance 0 plac$ 9 a dry colorimet] tube & #a c4c4 ( alcohol1#bjf previ\sly di/ill$ ov] ,na,o,h1 0 add$4 ,aft] ! acetylsalicylic acid _h dissolv$1 #dh c4c4 ( wat] & #a c4c4 ( fre% #j4a p] c5t4 f]ric *loride 7,fe,cl4#f;,h,o7 solution 7 add$4 ,at ! same "t a control 0 run by treat+ #a c4c4 ( a 8/&>d0 salicylate solution ! same z above4#bjg ,if )9 two m9utes ! color giv5 by acetylsalicylic acid is n m int5se ?an ! color giv5 by ! 8/&>d10 ! pres5ce ( n m ?an #j4a p] c5t4 free salicylic acid is prov$4#bjh #bjf ,an excess ( alcohol de/roys or less5s ! color :5 only a v m9ute am\nt ( salicylic acid is pres5t4 #bjg ,! control %\ld be made ea* "t z /&+ 9 ! air *anges its t9ctorial p[]4 #bjh ,! pres5ce ( pure acetylsalicylic acid does n seem to affect ! iron 7,fe7 salicylic acid coloration4 ,! small am\nt ( acetic acid 0 add$ to ! sodium salicylate control solution 7#a7 to /imulate an acidity approximat+ ! acidity ( ! acetylsalicylic acid1 & 7#b7 s9ce acetylsalicylic acid gives by hydrolysis bo? acetic acid & salicylic acid1 x 0 ?\ght advisable to add acetic acid to ! /&>d4 ,if !re is any free acetic acid 9 a sample ( acetylsalicylic acid conta9+ salicylic acid 7:i* ,i believe is g5]ally ! case :5 salicylic acid is pres5t7 !n x w\ld modify ! color giv5 by ! same am\nt ( salicylic acid alone4 ,= ?is reason x 0 ?\ght to be m comp>able to h ! /&>d conta9 a slight am\nt ( acetic acid4 ,! solutions us$ 7 prep>$ z foll[s3 ,r$i/ill$ alcohol 0 treat$ ) a small am\nt ( sodium hydroxide = tw5ty-f\r h\rs1 !n aga9 di/ill$4 ,! color /&>d 0 made by dissolv+ #j4aaf gm4 ( dri$ sodium salicylate 9 wat]1 add+ #a m9im ( glacial acetic acid1 & mak+ up to #a1jjj c4c4 ,ea* c4c4 repres5ts #j4a mg4 ( salicylic acid4#bji #bji ,?is /&>d is some:at simil> to ! "o propos$ by ,t4 ,w4 ,?oburn & ,paul ,j4 ,hanzlik1 ,j4 ,biol4 ,*em41 #bc1 #age4 ,! f]ric *loride solution 0 made by dilut+ #a c4c4 f]ric *loride 7,fe,cl4#f;,h,o7 te/ solution ,u4 ,s4 ,p4 ) #ii c4c4 ( wat]4 ,! dilut$ solution mu/ be fre%ly prep>$ ea* day4 ,) "o exception1 all ( ! comm]cial specim5s exam9$ respond$ satisfactorily to ! above te/ %[+ less ?an #a "p salicylic acid 9 #a1jjj p>ts acetylsalicylic acid4 ,! individual results are giv5 9 ! accompany+ table4 ,,melt+ ,,po9t ,,& ,,salicylic ,,acid ,,det]m9ations ,melt+ ,po9t ,free ,salicylic ,acid ,,br& ,correct$ ,colorimetrically ,acetylsalicylic acid1 #acj4j-aca4j ,color$1 b %[+ ,p4 ,w4 ,r4#a less ?an #j4a p] c5t4 ,acetylsalicylic acid1 #acj4j-aca4j ,no color ,millik9#b ,acetylsalicylic acid1 #abi4j-acj4j ,no color ,millik9#b #e-;gra9 capsules ,acetylsalicylic acid1 #abh4j-abi4j 7a7 ,color$1 b %[+ less ,millik91#a ?an #j4a p] c5t4 7a7 #e-;gra9 capsules#c #abe4e-abf4e 7b7 ,consid]ably m ?an #j4a p] c5t4 7b7 ,acetylsalicylic acid1 #aca4j-acb4j ,no color ,squibb#b ,acetylsalicylic acid #aca4j-acb4j ,no color 7,aspir971#a ,monsanto ,acetylsalicylic acid1 #acj4e-aca4e ,color$1 b %[+ less ,m4 ,c4 ,w4#a ?an #j4a p] c5t4 ,acetylsalicylic acid1 #aca4e-acb4e ,color$1 b %[+ less ,m4 ,c4 ,w4#a ?an #j4a p] c5t4 ,acetylsalicylic acid1 #aca4j-acb4j ,color$1 b %[+ less ,m4 ,c4 ,w4#a ?an #j4a p] c5t4 ,aspir91 ,bay]#a 7be=e pat5t #aca4e-acb4e ,no color expir$7 ,aspir91 ,bay]#a #d 7aft] pat5t #abh4e-abi4e ,color$1 b %[+ less expir$7 ?an #j4a p] c5t4 ,aspir91 ,bay]#a #d 7aft] pat5t #abi4e-acj4e ,color$1 b %[+ less expir$7 ?an #j4a p] c5t4 ,aspir91 ,lehn #acj4e-aca4e #j4a p] c5t4 & ,f9k#b ,aspir91 ,lehn #acj4e-aca4e ,color$1 b %[+ less & ,f9k#b ?an #j4a p] c5t4 ,aspir91 ,lehn #aca4j-acb4j ,color$1 b %[+ less & ,f9k#a ?an #j4a p] c5t4 #a ,obta9$ on ! op5 m>ket4 #b ,obta9$ f manufactur]4 #c ,"o-?ird ( ! capsules 7a7 conta9$ a :ite p[d]2 two-?irds ( ! capsules 7b7 conta9$ a p9k p[d] hav+ /rong odor ( acetic acid & n comply+ ) ! te/s4 #d ,n describ$ 9 8,new & ,non(ficial ,rem$ies1 #aiag02 ! o!r products are4 ,,o!r ,,te/s ,new & ,non(ficial ,rem$ies1 #aiag1 requires t acetylsalicylic acid %all =m a cle> solution ) w>m sodium c>bonate solution2 t sulfates1 *lorides & heavy metals %all be abs5t2 t #j4e gm4 %all leave no weighable a%4 ,all ! br&s report$ 9 ?is pap] compli$ ) ^! requirem5ts4 ,s f> !re has be5 no satisfactory quantitative e/imation ( acetylsalicylic acid4 ,true1 v>i\s me?ods h be5 propos$1 b !y are objectionable4 ,x 0 ?\ght t hydrolysis ( acetylsalicylic acid & !n titrat+ ! solution by comp>+ ! color =m$ by f]ric *loride ) t ( a /&>d control might yield int]e/+ results1 provid+ t ! conditions 7 alike4 ,= ?is purpose #a gm4 ( acetylsalicylic acid 0 dissolv$ 9 #aj c4c4 ( alcohol & dilut$ to #a1jjj c4c4 ,! solution 0 !n heat$ at #ih to #ajj ,c4 = two h\rs1 all[+ ! alcohol to evaporate1 !n all[$ to /& at room temp]ature 7#bb ,c47 = tw5ty-two h\rs4 ,aft] add+ wat] suffici5t to make #a1jjj c4c41 x 0 comp>$ colorimetrically = salicylic acid /r5g?4 ,! am\nt ( hydrolysis v>i$ s ) diff]5t samples "u ! same conditions1 t x 0 realiz$ t an approximate assay by ?is me?od 0 unreliable4 ,if ! assay 7 made "u m exact conditions1 quantitative comp>isons might be possible4 ,9 "o exp]im5t1 aft] sixty days ! hydrolysis ( ! acetylsalicylic acid 0 #fa p] c5t41 :i* is 9 r\gh agreem5t ) ! "w ( ,tsaklatos & ,hor%4#baj #baj ,apo?4 ,ztg41 #aiae1 p4 #bdg2 ,bull4 soc4 *em41 #ag 7#aiae71 #dja4 8,/udies ( ! decomposition ( aspir9 det]m9$ by titrametric me?ods & by conductivity measurem5ts indicate t ! reaction is exce$+ly complex10 ,t4 & ,h4 ,*em4 ,abs41 #aj1 #eia4 ,,discussion ,ap>t f ! propos$ revision ( ! /&>ds = ! melt+ po9t & limit ( salicylic acid 9 acetylsalicylic acid1 ! exam9ation %[s t !re is no appreciable diff]5ce betwe5 ! v>i\s br&s ( acetylsalicylic acid exam9$1 all ( !m ) "o exception 7acetylsalicylic acid1 ,millik91 #e-;gra9 capsules1 pur*as$ on ! op5 m>ket7 comply+ ) ! te/s describ$ 9 ?is pap]4 ,! ,j\rnal ( ! ,am]ican ,m$ical ,association1 9 pa/ ye>s1 has prote/$ repeat$ly aga9/ ! monopoly giv5 to ! ,bay] ,company = _! 8,aspir910 cont5d+ t acetylsalicylic acid 7aspir97 0 n new1 & t 8,aspir91 ,bay]0 0 simply a good br& ( acetylsalicylic acid :i* c\ld be b\ght 9 =eign c\ntries at mu* l[] prices ?an "h4 ,al?\gh ! pat5t 9 ! ,unit$ ,/ates has expir$1 8,aspir91 ,bay]0 is /ill be+ retail$ at high] prices ?an o!r products :i* are n[ enjoy+ ! privilege ( ,am]ican manufacture4 ,mr4 ,paul ,bakewell1#baa 9 an op9ion answ]+ ! w>n+ circul> ( ! ,bay] ,co4 9 ref]5ce to ! use ( ! ^w 8aspir90 by firms o!r ?an ,bay]1 argues v ably t acetylsalicylic acid1 be=e ! pat5t 0 grant$1 meant ! impure sub/ance :i* 0 n us$ !rapeutically1 :ile 8aspir90 0 designat$ z ! improv$ product 7a new article ( manufacture1 ! p>ticul> acetylsalicylic acid made "u ! ,h(fman pat5t7 & 8is ! sub/ance n[ kn[n 9 ph>macy z aspir90 7/atem5t made by an (fic] ( ! ,f>b5fabrik5 ( ,elb]feld ,co4 9 ,u4 ,s4 ,circuit ,c\rt1 #aiji74 ,! products report$ 9 ?is pap] are 7) ! "o exception7 ! same z describ$ 9 ! ,h(fman pat5t1 &1 9 ! s5se ( ,mr4 ,bakewell's argum5t1 are 8aspir940 ,h[ev]1 x w\ld seem bett] if ! "n acetylsalicylic acid1 in/ead ( aspir91 7 us$1 especially by physicians 9 _! prescriptions because 7#a7 x is a g5]ic1 sci5tific "n2 7#b7 8,aspir91 ,bay]0 is sold at high] prices ?an o!r products1 :]eas *emically equival5t products sold "u ! descriptive "n may be pur*as$ at a l[] price4 ,f9ally1 ! manufacture ( acetylsalicylic acid 9 ?is c\ntry is ano!r example ( ! fact t ,am]ican *emi/s c produce ! drug syn!tics1 & at ! same "t make products z good z1 if n bett] ?an1 ^? ( ,g]man orig94 #baa 8,9 ! ,matt] ( ,aspir94 ,answ] to ! w>n+ circul> ( ! ,bay] ,co4 ( ,june #a1 #aiag10 by ,mr4 ,paul ,bakewell1 ,monsanto ,*emical ,works4 ,i express my appreciation to ,dr4 ,w4 ,a4 ,puckn] = 8 k9d int]e/4--7,f ! ,j\rnal ( ,indu/rial & ,eng9e]+ ,*emi/ry1 ,april1 #aiah47 ,,! ,,/&>dization ,,( ,,comm]cial ,,bismu? ,,tribromph5ate ,william ,rabak1 ,ph4,g41 ,sc4,b4 ,?is "w 0 begun 9 view ( a reque/ receiv$ by ! ,c\ncil on ,ph>macy & ,*emi/ry f ! ,m$ical ,section ( ! ,c\ncil ( ,national ,def5se = a report on ! quality ( bismu? tribromph5ate1 (f]$ to ! gov]nm5t by a c]ta9 firm4 ,9 submitt+ a specim5 ( its product1 8,bismu? ,tribromph5olate10 ! firm claim$ t 8x is ( high "*1 mat*+ exactly ! ,g]man product =m]ly import$ into ?is c\ntry10 & express$ ! belief t x w\ld be f\nd to con=m to ! /&>ds = ?is prep>ation 9 ,new & ,non(ficial ,rem$ies4 ,lat] a second specim5 0 receiv$ f ! same company1 ) ! reque/ t ?is be sub/itut$ = t fir/ receiv$4 ,x 0 expla9$ t ! fir/ _h be5 tak5 f an exp]im5tal lot1 & t ! second1 tak5 f ! regul> factory output1 0 id5tical ) ! fir/ except t x 0 free f odor because ( ! m ?or\gh wa%+ to :i* x _h be5 subject$4 ,accord+ly1 ! exam9ation :i* is report$ bel[ ref]s to ! second specim5 only4 ,new & ,non(ficial ,rem$ies1 #aiah1 def9es bismu? tribromph5ate z basis bismu? tribromph5ate hav+ ! =mula ,bi7,c,h,br,o7,,oh4,bi,o1 & x is requir$ to yield n less ?an #di4e p] c5t4 ( bismu? oxid 7! *emical =mula requires #df4b p] c5t4 bismu?1 or #ea4f p] c5t4 bismu? oxid1 ,bi,o1 & #di4b p] c5t4 tribromph5ate1 ,c,h,br4,,oh74 ,x describes x z a 8f9e1 yell[1 ne>ly odorless & ta/eless p[d]1 neutral 9 reaction10 & 8only slightly soluble 9 wat]1 alcohol1 *lor(orm1 liquid petrolatum & vegetable oils40 ,x is requir$ to yield tribromph5ol 7to :i* a melt+ po9t ( #ie ,c4 is assign$7 :5 decompos$ by alkali & ! alkali tribromph5ate decompos$ by acid1 ! sep>at$ tribromph5ol purifi$ & dri$4 ,z ! ,new & ,non(ficial ,rem$ies description appe>$ loosely drawn--x _h be5 bas$ on in=mation furni%$ = ! product ,x](orm :5 ?is1 because ( pat5t protection1 0 ! only bismu? tribromph5ate on ! m>ket--x 0 decid$ to include 9 ! exam9ation also specim5s ( ! two br&s ( ,bismu? ,tribromph5ate includ$ 9 ,new & ,non(ficial ,rem$ies1 namely1 ,bismu? ,tribromph5ate-,m]ck 7,m]ck & ,company7 & ,x](orm-,heyd5 7,! ,heyd5 ,*emical ,works74 ,! ,m]ck specim5 _h be5 receiv$ by ! ,c\ncil f ,m]ck & ,company 9 #aiae1 :ile ! ,heyd5 prep>ation 0 obta9$ direct f ! firm's ,*icago bran* 9 ,april1 #aiah4 ,at ?is "t ,bismu? ,tribromph5ate-,m]ck c\ld n be obta9$ f ! ,*icago :olesale h\ses4 ,all ?ree specim5s 7 ne>ly odorless4 ,two ( ! specim5s 7! ,rese>* ,c\ncil ,specim5 & ,m]ck products7 7 ( a lemon-yell[ color1 :ile ! ,heyd5 prep>ation 0 ( a grayi% color4 ,,bismu? ,,det]m9ation ,f\r me?ods = ! det]m9ation ( ! bismu? cont5t ( ! specim5s 7 tri$3 7,a74 ,direct ,ignition to ,bismu? ,oxid4--,?is me?od 0 ab&on$ because ( ! t5d5cy to ignite sudd5ly dur+ ! inc9]ation & ! consequ5t loss ( mat]ial4 7,b74 ,! ,me?od ( ! ,japanese ,ph>macopeia1 ,?ird ,revis$ ,edition1 ,translat$ by ! ,ph>maceutical ,society ( ,japan4--,! me?od consi/s 9 treatm5t ( ! product ) nitric acid1 evaporation & subsequ5t heat+ to bismu? oxid4 ,?is me?od also 0 ab&on$ because ( t5d5cy t[>d sudd5 ignition ) loss ( mat]ial4 7,c74 ,! ,me?od ( ,kollo 7,apo!k] ,zeitung1 #aiaj1 p4 #ii74--,! me?od consi/s 9 decomposition ( ! product by heat+ on wat] ba? ) normal sodium hydroxid solution1 ) =mation ( soluble sodium tribromph5ate & insoluble bismu? hydroxid4 ,! bismu? hydroxid is collect$ on a filt]1 wa%$ ) hot wat] until a few drops ( ! filtrate no long] turn litmus pap] blue1 dri$ & heat$ to con/ant weight & weigh$ z bismu? oxid4 7,d74 ,a4 ,m4 ,a4 ,me?od 7,reports ,a4 ,m4 ,a4 ,*em4 ,lab41 #aiaa1 p4 #ah74--,?is me?od consi/s 9 dissolv+ ! product 9 hot1 /rong hydro*loric acid1 dilut+1 filt]+ & precipitat+ by saturation ) hydrog5 sulphid4 ,! bismu? sulphid obta9$ is dissolv$ 9 nitric acid & f ! solution obta9$ ! bismu? is precipitat$ by addition ( an excess ( ammonium hydroxid & ammonium c>bonate4 ,! precipitate is collect$ & conv]t$ to bismu? oxid by heat4 ,! foll[+ tabulation %[s ! results obta9$ by ,me?ods 8,c0 & 8,d03 ,,table #a4--;,,bismu? ,,cont5t ,,( ,,bismu? ,,tribromph5ate ,gm4 ( ,gm4 ( ,p] ,c5t4 ,me?od ,salt ,bi,o ( ,bi,o ,no4 #a ,rese>* ,c\ncil ,spec ,c #b4acab #a4aged #ee4a ,no4 #a ,rese>* ,c\ncil ,spec ,d #j4eaea #j4bggb #ej4jc ,no4 #b 7,m]ck ,company7 ,c #b4jbhg #a4bedc #fa4h ,no4 #b 7,m]ck ,company7 ,d #j4ejfd #j4bfcd #eb4ja ,no4 #c 7,heyd5 ,*em4 ,works7 ,c #b4jdgb #a4fjbj #gh4b ,no4 #c 7,heyd5 ,*em4 ,works7 ,d #j4ebbg #j4cedf #fg4h ,x is se5 f ! tabulation t ! results obta9$ by ! ,kollo me?od 7,me?od ,c7 are high] ?an ^? by ! sulphid me?od 7,me?od ,d7 & t duplicate det]m9ations %[ a r wide v>iation4 ,! results by ! sulphid me?od are some:at l[] ?an ^? by ! ,kollo me?od1 b duplicates agree fairly well4 ,9 view ( ! fact t ! ,kollo me?od w give excessive results if impurities su* z talcum1 etc41 are pres5t & 9 consid]ation ( ! satisfactory results obta9$ 9 previ\s "w ) ! sulphid me?od1 ! figures obta9$ by ?is me?od are tak5 z indicative ( ! bismu? cont5t ( ! specim5s exam9$4 ,calculat+ ! p] c5t4 ( bismu? oxid obta9$ to bismu? 7,bi71 ! foll[+ values are obta9$3 ,bismu? ,tribromph5olate1 ,rese>* ,c\ncil ,specim53 ,bismu?1 #dd4h p] c5t4 ,bismu? ,tribromph5ate-,m]ck1 ,m]ck ,co43 ,bismu?1 #df4f p] c5t4 ,x](orm1 ,heyd5 ,*emical ,works3 ,bismu?1 #fj4g p] c5t4 ,,total ,,tribromph5ol ,! cont5t ( tribromph5ate radical1 ,c,h,br,o-1 0 det]m9$ by ! me?od ( ,kollo 7,apo!k] ,zeitung1 #aiaj1 p4 #ii74 ,x consi/s 9 titrat+ ! filtrate ( ! bismu? oxid det]m9ation ( ,kollo1 describ$ "u 8,c0 7bismu? det]m9ations71 ) normal hydro*loric acid1 us+ ph5olph?ale9 z an indicator4 ,! cubic c5timet]s ( normal alkali consum$ multipli$ by ! !oretical factor #j4cca gives ! weight ( tribromph5ol 7comb9$ & free7 conta9$ 9 ! specim54 ,! foll[+ results 7 obta9$3 ,,table #b4--;,,det]m9ation ,,( ,,total ,,tribromph5ol ,,9 ,,bismu? ,,tribromph5ate ,gm4 ,tribromph5ol ,gm4 ( ,calculat$ f ,p] ,c5t4 ,salt ,!oretical ( ,total ,tak5 ,factor ,tribromph5ol ,no4 #a 7,rese>* ,c\ncil ,spec47 #a4ghag #a4jeib #ei4dd ,no4 #b 7,m]ck ,co47 #j4igdc #j4efbg #eg4ge ,no4 #c 7,heyd5 ,*em4 ,works7 #b4jddj #j4dcjc #ba4jd ,,uncomb9$ ,,tribromph5ol ,! def9ite *emical =mula giv5 9 ,new & ,non(ficial ,rem$ies = bismu? tribromph5ate & ! /atem5t t x is 8only slightly soluble 9 444 alcohol 4440 requires ! abs5ce ( uncomb9$ tribromph5ol1 b no me?od = its detection or det]m9ation is provid$4 ,9 ! ,u4 ,s4 ,pat5t #eaf1ceh 7expir$ ,m>* #ac1 #aiaa71 issu$ to ,bruno ,ri*>d ,seif]t1 assignor to ,dr4 ,f4 ,von ,heyd51 = 8,ph5ol ,bismu? ,comp\nd0 ! fre$om f uncomb9$ tribromph5ol 0 provid$ = by ! direction to wa% ) alcohol ! product obta9$4 ,9 ! ,swiss ,ph>macopeia ! p]missible cont5t ( uncomb9$ tribromph5ol is limit$ ?us3 8,if #j4e gm4 be %ak5 ) #e c4c4 ( alcohol & #a c4c4 ( ! filtrate be dilut$ ) #ae c4c4 ( wat]1 nei!r a turbidity nor a floccul5t precipitate %\ld appe>44440 ,:5 ?is te/ 0 appli$ to ! ?ree specim5s "u exam9ation1 ! ,m]ck & ,heyd5 specim5s compli$1 :ile ! ,rese>* ,c\ncil specim5 did n comply1 ) ?is requirem5t4 ,me?od #a4--;,ab\t #a gm4 ( bismu? tribromph5ate 0 plac$ 9 a flask1 #bj c4c4 ( #ie p] c5t4 alcohol add$ & %ak5 = fifte5 m9utes1 aft] :i* x 0 filt]$ by suction ?r\gh a ,goo* filt] into an ,erl5mey] flask4 ,! flask 0 r9s$ ) #aj c4c4 ( alcohol & f9ally ! filt] 0 wa%$ ) #aj c4c4 ( alcohol1 #be c4c4 ( t5?-normal sodium hydroxid solution 7 add$ to ! alcoholic filtrate 7:i* 0 ne>ly b n p]fectly cle>7 conta9+ ! tribromph5ol1 & ! residual alkali titrat$ ) t5?-normal hydro*loric acid4 ,! numb] ( cubic c5timet]s ( t5?-normal alkali consum$ multipli$ by #j4cca gave ! weight ( tribromph5ol 7,table #c74 ,,table #c4--;,,det]m9ation ,,( ,,free ,,tribromph5ol ,gm4 ,tribromph5ol ,calculat$ f ,p] ,c5t4 ,gm4 ( ,!oretical ,free ,salt ,tak5 ,factor ,tribromph5ol ,rese>* ,c\ncil ,spec4 #b4ccea #j4chjf #af4ca ,m]ck ,co4 #j4gihj #j4jcfd #d4ef ,heyd5 ,*emical ,works #a4idfj #j4jacb #j4fh ,me?od #b4--;,ab\t #b gm4 ( bismu? tribromph5ate 7 plac$ 9 a glass /opp]$ ,erl5mey] flask1 #ajj c4c4 ( alcohol 7 measur$ 9 & %ak5 dur+ "o-half h\r & all[$ to /& ov] night4 ,fifty c4c4 ( ! sup]natant liquid 7 !n remov$ by means ( a pipet1 a slight excess ( t5?-normal sodium hydroxid add$ & ! residual alkali titrat$ ) t5?-normal ,h,cl4 ,table #d gives results obta9$4 ,,table #d4--,,p] ,,c5t4 ,,( ,,tribromph5ol ,,by ,,me?od #b ,gm4 ,tribromph5ol ,calculat$ f ,p] ,c5t4 ,gm4 ( ,!oretical ,free ,salt ,tak5 ,factor ,tribromph5ol ,rese>* ,c\ncil ,spec4 #b4jgab #j4cije #ah4he ,m]ck ,co4 #a4idag #j4jgfj #c4ib ,heyd5 ,*emical ,works #b4jddj #j4jaih #j4ig ,table #e gives a comp>ison ( ! results obta9$ by ! two me?ods4 ,,table #e4--;,,comp>ison ,,( ,,results ,,by ,,me?ods #a ,,& #b ,me?od #a ,me?od #b ,rese>* ,c\ncil ,spec4 #af4ca #ah4he ,m]ck ,co4 #d4ef #c4ib ,heyd5 ,*emical ,works #j4fh #j4ig ,! results obta9$ 9 ,me?od #a 7! p]colation me?od7 app>5tly are reliable &1 z ! me?od is ! m simple1 may be giv5 pref]5ce4 ,,comb9$ ,,tribromph5ol 7,,tribromph5ate7 ,! am\nt ( tribromph5ol exi/+ 9 ! specim5 9 comb9ation 0 calculat$ by subtract+ f ! p] c5t4 ( total tribromph5ol det]m9$1 ! p] c5t4 ( free tribromph5ol f\nd by ,me?od #a4 ,! figures obta9$ are giv5 9 ,table #f4 ,,table #f4--,,! ,,tribromph5ate ,,cont5t ,,( ,,bismu? ,,tribromph5ate ,p] ,c5t4 ( ,comb9$ ,tribromph5ol ,rese>* ,c\ncil ,specim5 #dc4ac ,m]ck ,co4 #ec4ai ,heyd5 ,*emical ,works #bj4cf ,,summ>y ,f ! =ego+ ! specim5s exam9$ conta9 ! p]c5tages %[n 9 ,table #g ( bismu? 7,bi71 comb9$ tribromph5ate & free tribromph5ol4 ,,table #g4--,,p]c5tages ,,( ,,bismu? ,,& ,,( ,,comb9$ ,,tribromph5ate ,,& ,,free ,,tribromph5ol ,p] ,c5t4 ,p] ,c5t4 ,p] ,c5t4 ,comb9$ ,free ,bismu? ,tribromph5ate ,tribromph5ol ,rese>* ,c\ncil ,specim5 #dd4h #dc4ac #af4ca ,m]ck ,co4 #df4f #ec4ai #d4ef ,heyd5 ,*emical ,works #fj4g #bj4cf #j4fh ,?is exam9ation %[s3 #a4 ,! ,bismu? ,tribromph5olate submitt$ to ! ,c\ncil ( ,national ,def5se1 does n correspond to ! description ( bismu? tribromph5ate 9 ,new & ,non(ficial ,rem$ies4 #b4 ,z n[ suppli$1 ,x](orm-,heyd5 does n meet ! requirem5ts = bismu? tribromph5ate1 nor does its composition correspond to t ( ! product =m]ly suppli$4 #c4 ,! description 9 ,new & ,non(ficial ,rem$ies ( bismu? tribromph5ate %\ld provide an upp]1 z well z a l[]1 limit = ! bismu? cont5t2 x %\ld provide te/s = ! abs5ce ( adult]ants1 & also set a limit ( p]missible uncomb9$ tribromph5ol4 ,report to ,c\ncil ( ,national ,def5se ,! results ( ?is exam9ation ) ref]5ce to ! ,rese>* ,c\ncil specim5 hav+ be5 submitt$ to ! ,c\ncil on ,ph>macy & ,*emi/ry1 ?is body advis$ ! ,m$ical ,section ( ! ,c\ncil ( ,national ,def5se z foll[s3 #a4 ,! specim5 ( 8,bismu? ,tribromph5olate0 s5t to ! ,c\ncil ( ,national ,def5se complies ) ! ,new & ,non(ficial ,rem$ies description = bismu? tribromph5ate1 except t x conta9s consid]able am\nts 7approximately #af p] c5t47 ( alcohol-soluble1 uncomb9$ tribromph5ol4 ,revision ( ,n4 ,n4 ,r4 ,/&>ds ,! results ( ! exam9ation ( ! ?ree specim5s 7 s5t to ! ,heyd5 ,*emical ,works & to ,m]ck & ,co4 79 ea* case disclos+ ! id5tity ( ! p>ticul> firm's product71 ask+ aid 9 ! /&>dization ( ! product4 ,aft] ,m]ck & ,co4 _h submitt$ valuable advice = a revision ( ! some:at loosely drawn /&>ds = bismu? tribromph5ate 9 ,n4 ,n4 ,r41 #aiah1 ! inquiry :e!r ! foll[+ propos$ revision ( ! description ( bismu? tribromph5ate 9 ,new & ,non(ficial ,rem$ies 0 acceptable1 0 submitt$ to bo? firms3 ,,bismu? ,,tribromph5ate4--,bismu?i ,tribromph5as4--,bismu? ,tribromph5ol4--,x](orm4--,a basic bismu? tribromph5ate ( v>iable composition4 ,an amorph\s1 yell[1 ne>ly odorless & ta/eless p[d]1 neutral to moi/5$ litmus pap]4 ,x is only slightly soluble 9 wat]1 alcohol1 *lor(orm1 liquid petrolatum & vegetable oils4 ,alkalies & /rong acids decompose x4 ,x is /able at temp]atures bel[ #abj ,c4 ,:5 ab\t #a gm4 ( ! salt is boil$ ) #aj c4c4 ( sodium hydroxide te/ solution1 ! liquid filt]$1 & ! filtrate acidulat$ ) sulphuric acid1 ! :ite curdy precipitate produc$1 :5 wa%$ & dri$1 melts at #ij to #ie ,c4 7tribromph5ol74 ,! cont5ts ( ! filt] dissolve completely 9 dilute hydro*loric acid 7insoluble in]t mat]ial74 ,boil #a gm4 ( bismu? tribromph5ate ) #bj c4c4 ( a mixture ( equal p>ts ( acetic acid & di/ill$ wat]1 cool ! solution & filt]4 ,free ! filtrate f bismu? by ! addition ( hydrog5 sulphide1 boil ! mixture & aga9 filt]4 ,! latt] filtrate leaves n m ?an #j4jje gm4 ( residue on evaporation & g5tle ignition 7alkalies & alkali e>?s74 ,%ake = "o m9ute 9 a sep>atory funnel1 #b gm4 ( bismu? tribromph5ate1 #bj c4c4 ( e!r1 & #bj c4c4 ( a mixture ( equal volumes ( hydro*loric acid & di/ill$ wat]4 ,draw (f ! aque\s portion & conc5trate to ab\t #d c4c42 p\r x into #ajj c4c4 di/ill$ wat]1 filt]1 evaporate ! filtrate on ! wat] ba? to #cj c4c41 aga9 filt] & divide ?is filtrate into portions ( #e c4c4 ea*4 ,mix "o portion ) an equal volume ( dilute sulphuric acid2 x does n become cl\dy 7lead74 ,treat ano!r portion ) a slight excess ( ammonia wat]2 ! sup]natant liquid does n exhibit a blui% t9t 7copp]74 ,ano!r portion is n imm$iately affect$ by b>ium nitrate te/ solution 7sulphate74 ,heat g5tly a mixture ( ab\t #j4b gm4 ( bismu? tribromph5ate ) #e c4c4 ( potassium hydroxide te/ solution & ab\t #j4b gm4 ( alum9um wire2 ! vapors evolv$ d n turn r$ litmus blue 7nitrates74 ,%ake #a gm4 ( bismu? tribromph5ate frequ5tly dur+ fifte5 m9utes ) #cj c4c4 ( alcohol 7#ie p] c5t471 filt] & r9se flask ) two sep>ate #aj c4c4 portions ( alcohol1 all[+ ! wa%+s to run ?r\gh filt]4 ,to ! comb9$ filtrate & wa%+s add #bj c4c4 ( t5?-normal sodium hydroxide & a few drops ( ph5olph?ale9 solution & det]m9e ! excess ( alkali ) t5?-normal hydro*loric acid4 ,n m ?an #a c4c4 ( t5?-normal sodium hydroxide %\ld h be5 consum$ by ! alcoholic liquid 7free tribromph5ol74 ,add #b c4c4 ( nitric acid to #b gm4 ( bismu? tribromph5ate 9 a porcela9 crucible1 c>efully evaporate to dryness on a s& ba? & inc9]ate4 ,dissolve ! residue 9 #e c4c4 ( conc5trat$ hydro*loric acid & add to ! solution #aj c4c4 ( a saturat$ solution ( /ann\s *loride 9 conc5trat$ hydro*loric acid4 ,! mixture %\ld n d>k5 on /&+ ?irty m9utes 7ars5ic74 ,mix #j4e gm4 ( ! salt ) #aj c4c4 ( a mixture ( equal p>ts ( hydro*loric acid1 ,u4 ,s4 ,p41 & di/ill$ wat]4 ,no eff]vesc5ce %\ld occur 7c>bonate74 ,to ab\t #j4e gm4 ( bismu? tribromph5ate1 accurately weigh$1 add #bj c4c4 ( hydro*loric acid & dige/ on wat] ba?4 ,add #aej c4c4 ( di/ill$ wat] & filt]4 ,r9se ! beak] ) #cj c4c4 ( di/ill$ wat] & all[ ! wa%+s to run ?r\gh ! filt]4 ,saturate ! comb9$ filtrate & wa%+s ) hydrog5 sulphide1 filt] (f ! bismu? sulphide1 wa% & dissolve 9 hot dilute nitric acid4 ,add a slight excess ( ammonia wat] foll[$ by #b c4c4 ( ammonium c>bonate te/ solution4 ,all[ to /& ?irty m9utes1 filt] (f ! precipitat$ bismu? hydroxide & heat to con/ant weight at dull r$ heat4 ,! residue ( bismu? oxide 7,bi,o7 %\ld n be less ?an #de p] c5t4 nor m ?an #ee p] c5t4 ( ! orig9al weight ( bismu? tribromph5ate tak51 correspond+ to n less ?an #dj p] c5t4 nor m ?an #di p] c5t4 ( bismu?4 ,! ,heyd5 ,*emical ,works accept$ ! propos$ monograph4 ,reg>d+ ! ,laboratory's f9d+s1 ! firm /at$ t 8! product _h to be made 9 ?is c\ntry aft] importations f ,europe became impossible & ! fir/ lots 7 n fully up to ! /&>d40 ,lat] ! firm /at$ t x c\ld furni% a product :i* x consid]$ equal to t :i* 0 previ\sly import$ & (f]$ to submit 8samples ( ! new mat]ial40 ,m]ck & ,co4 ackn[l$g$ ! receipt ( ! monograph b made no /atem5t z to its acceptance or sugge/ions = its revision4 ,z ! new monograph 0 accept$ by ! ,heyd5 ,*emical ,works & z ,m]ck & ,co4 (f]$ no objections1 x 0 adopt$ = ,n4 ,n4 ,r41 #aiai1 by ! ,c\ncil on ,ph>macy & ,*emi/ry4 ,9 ,novemb]1 #aiah1 ,m]ck & ,co4 s5t a specim5 label$ 8,bismu? ,tribromph5ate-,m]ck10 8,m]ck & ,co41 ,new ,york1 ,di/ributors & ,gu>antors0 & wrote3 8,y w notice ?is sample con=ms 9 ne>ly all details to ! te/s submitt$ ) our lett] ( ,june #d4 ,we h be5 able to produce bett] goods1 b j at pres5t unsatisfactory />t+ mat]ial confronts u40 ,exam9ation ( ! specim5 demon/rat$ t x 0 soluble to a consid]able ext5t 9 alcohol 7! ,n4 ,n4 ,r41 #aiah1 description provides t x %\ld be only slightly soluble 9 alcohol7 &1 accord+ to ! /&>ds adopt$ = ,new & ,non(ficial ,rem$ies1 #aiai1 conta9$ #ah p] c5t4 ( uncomb9$ tribromph5ol 7m ?an five times ! p]mitt$ am\nt74 ,9 ,decemb]1 #aiah1 ,m]ck & ,co4 submitt$ ano!r specim5 & said3 8,we believe ?is is a bett] grade ?an we h be5 able to make 9 ! rec5t pa/4 ,x seems to meet all ! te/s = ,n4 ,n4 ,r41 #aiai1 ) two exceptions3 ^! are 7a7 solubility 9 alcohol1 & 7b7 ! te/ = uncomb9$ tribromph5ol40 ,:5 ! two rec5t samples ( bismu? tribromph5ate-,m]ck & two samples ( ,x](orm-,heyd5 7 exam9$ accord+ to ! new monograph ! results giv5 9 ,table #h 7 obta9$4 ,,table #h4--;,,exam9ation ,,( ,,tribromph5ate ,,& ,,x](orm #a4 ,,bismu?4 ,weight ( ,p] ,c5t4 ,weight ,bi,o ( ,br& & ,date ,receiv$ ,tak51 ,obta9$1 ,bismu?1 ,gm4 ,gm4 ,gm4 ,x](orm-,heyd5 7f mfr47 ,july1 #aiah #j4fged #j4cefe #dg4b ,x](orm-,heyd5 7op5 m>ket7 ,july1 #aiah #j4hbei #j4faef #ff4g ,bismu? tribromph5ate-,m]ck ,nov41 #aiah #j4dhhb #j4beab #df4a ,bismu? tribromph5ate-,m]ck ,dec41 #aiah #j4hhfi #j4ddie #de4e #b4 ,,uncomb9$ ,,tribromph5ol4 ,no4 ,c4c4 ,p] ,c5t4 ,weight ( ,t5?- ( ,free ,br& & ,date ,receiv$ ,tak51 ,normal ,na,o,h ,tribrom- ,gm4 ,consum$1 ph5ol ,c4c4 ,x](orm-,heyd5 7f mfr47 ,july1 #aiah #a #g4d #bd4e ,x](orm-,heyd5 7op5 m>ket7 ,july1 #aiah #a #j4g #b4c ,bismu? ,tribromph5ate-,m]ck ,nov41 #aiah #a #e4g #ah4h ,bismu? ,tribromph5ate-,m]ck ,dec41 #aiah #a #e #af4e ,9 view ( ! laboratory's report ! ref]ee ( ! ,c\ncil on ,ph>macy & ,*emi/ry 9 *>ge ( bismu? tribromph5ate recomm5d$ t ! acceptance ( ,x](orm-,heyd5 & bismu? tribromph5ate-,m]ck be )drawn1 b t ?is %\ld be )\t prejudice to _! re9/atem5t :5 satisfactory products are aga9 (f]$ = sale4 ,! ,c\ncil adopt$ ! recomm5dation ( ! ref]ee & accord+ly ,x](orm-,heyd5 & bismu? tribromph5ate-,m]ck are omitt$ f ,new & ,non(ficial ,rem$ies1 #aiai4 ,:5 ! laboratory's f9d+s ) reg>d to ,x](orm-,heyd5 & ! action ( ! ,c\ncil delet+ ! article f ,new & ,non(ficial ,rem$ies 0 report$ to ! ,heyd5 ,*emical ,works1 ! firm express$ regret t ef=ts to produce a product equal to t =m]ly obta9$ f ,g]many _h s f> n be5 successful & ann\nc$ t x _h decid$ to )draw ,x](orm-,heyd5 f ! m>ket = ! pres5t4 ,:5 ,m]ck & ,co4 0 advis$ 9 reg>d to ! report ( ! laboratory & ,c\ncil's action1 ?is firm que/ion$ ! feasibility ( produc+ a product meet+ ! ,c\ncil's /&>ds & sugge/$ t ! te/ = free tribromph5ol be revis$ to p]mit z mu* z #ae p] c5t4 ( ?is con/itu5t4 ,:5 ,m]ck & ,co4 0 rem9d$ t its product submitt$ 9 #aiae ess5tially compli$ ) ! adopt$ /&>ds 7an old sample ( ,x](orm-,heyd5 0 also f\nd to comply7 & t ! e/imate ( ! !rapeutic value ( bismu? tribromph5ate is bas$ on a product ess5tially devoid ( free tribromph5ol1 ! firm repli$3 8,z /at$ 9 our lett] ( ! #ab? in/41 we d n wi% to m>ket ! *emical unless x meets all legitimate requirem5ts ( ! physicians t use x4 ,if1 !re=e1 y\r /&>d proves to be good & x is comm]cially possible to make supplies con=m+ to x1 we %all d s4 ,we %all discont9ue ! article unless x is ( suitable quality40--7,f ,reports ,a4 ,m4 ,a4 ,*emical ,laboratory1 #aiah1 p4 #ic47 ,,! ,,/&>dization ,,( ,,proca9 ,,& ,,exam9ation ,,( ,,! ,,m>ket ,,supply ,proca91 :i* *emically is ! mono-hydro*lorid ( p>a-am9o-b5zoyldie?yl-am9o-e?anol1 is ! nonpropriet>y "n select$ by ! ,f$]al ,trade ,commission z ! (ficial designation = ! drug previ\sly kn[n "u ! propriet>y "n 8novoca9e40 ,be=e ! w> proca9 0 obta9able 9 ?is c\ntry only ?r\gh ! ,f>bw]ke ,hoe*/ ,co41 ! ,am]ican repres5tative ( ! ,g]man e/abli%m5t1 ,f>bw]ke1 vorm1 ,mei/]1 ,lucius & ,bru5+1 "u ! "n 8novoca9e40 ,?is monopoly on 8novoca9e0 0 ex]cis$ by virtue ( ,unit$ ,/ates pat5t ,no4 #habeed1 :i* 0 issu$ to ,alfr$ ,e9horn1 ,muni*1 ,g]many1 assignor to ,f>bw]ke1 vorm1 ,mei/]1 ,lucius & ,bru5+1 ,hoe*/ a4 ,m41 9 #aijf4 ,) ! outbreak ( ho/ilities1 ,congress pass$ ! ,trad+ ) ! ,enemy ,act1 & "u ?is1 ! ,f$]al ,trade ,commission took *>ge ( ! novoca9 pat5t ) a view ( secur+ ! production ( ?is product 9 ! ,unit$ ,/ates4 ,to ensure an adequate supply ( ! drug1 ! ,f$]al ,trade ,commission on recomm5dation ( ! ,committee on ,syn!tic ,drugs ( ! ,national ,rese>* ,c\ncil1 9 addition to issu+ a lic5se to ! ,f>bw]ke ,hoe*/ ,company 7:i* lic5se 0 lat] transf]r$ to ! ,h4 ,a4 ,metz ,laboratories7 grant$ au?ority to ! ,abbott ,laboratories & ! ,rector ,*emical ,company to manufacture x "u ! ,u4 ,s4 pat5t aft] specim5s submitt$ by ^! firms _h be5 f\nd satisfactory 9 ! ,association's laboratory & at ! ,cornell ,ph>macologic ,laboratory4 ,:5 ! fir/ specim5 ( ,am]ican made proca9 0 s5t to ! ,am]ican ,m$ical ,association ,*emical ,laboratory x 0 necess>y to "w out adequate /&>ds4 ,! /&>ds 7 =mulat$ on ! basis ( ! novoca9 monograph 9 ! ,g]man ,ph>macopeia1 #aiaj1 ,ed4 #e1 p4 #cfc1 ,rem$ia 8,hoe*/10 p4 #bdb1 & ,new & ,non(ficial ,rem$ies1 #aiah1 p4 #cb1 & ! "w c>ri$ out 9 ?is laboratory4 ,! foll[+ description has be5 adopt$ = ,new & ,non(ficial ,rem$ies1 #aiai1 & all specim5s ( proca9 7 subject$ to ^! te/s3 ,proca9 occurs 9 small colorless & odorless cry/als1 or a cry/all9e p[d] :i* if plac$ on ! tongue produces a transi5t s5se ( numbness4 ,x melts at #aec-aee ,c4#bab #bab ,u4 ,s4 pat5t numb] #hab1eed--! novoca9 pat5t--decl>es t ! salt melts at #aef ,c4 ,evid5tly bas$ on ?is1 ! ,g]man ,ph>macopoeia ,rem$ia 8,hoe*/0 & pa/ editions ( ,new & ,non(ficial ,rem$ies give ?is melt+ po9t4 ,two specim5s ( ,g]man made novoca9 obta9$ f our files1 /at$ to be manufactur$ by ,f>bw]ke-,hoe*/ vorm4 ,mei/]1 ,lucius & ,bru5+1 ,hoe*/ a4,m4 7 f\nd to melt1 respectively1 betwe5 #aed & #aee ,c4 & betwe5 #aec4e & #aed4e ,c4 :5 ! melt+ po9t 0 det]m9$ accord+ to ! directions ( ! ,u4 ,s4 ,ph>macopoeia1 #i? revision4 ,! v>i\s specim5s exam9$ at t "t melt$ betwe5 #aec & #aee ,c4 & x 0 decid$ to p]mit ?is range4 ,"o gm4 ( proca9 is soluble 9 #j4g c4c4 ( wat] & 9 #bj c4c4 ( alcohol ,u4 ,s4 ,p4 7#ie p] c5t47 at #bj ,c4 ,f ! aque\s solution1 :i* is neutral1 alkali hydroxids & c>bonates precipitate ! free base 9 ! =m ( a colorless oil1 :i* soon congeals to a cry/all9e mass1 b solutions ( sodium bic>bonate are miscible ) solutions ( proca9 )\t produc+ precipitations or turbidity4 ,dissolve #a gm4 ( proca9 9 wat]4 ,sep>ate portions ( ! solution yield a :ite precipitate ) potassium m]curic iodid solution1 a :ite precipitate ) m]curic *lorid te/ solution1 a br[n precipitate ) iod9 te/ solution & a yell[ precipitate ) picric acid te/ solution4 ,acidify a portion ) dilute nitric acid4 ,a :ite curdy precipitate is ?r[n d[n on ! addition ( silv] nitrate te/ solution4 ,dissolve ab\t #j4a gm4 ( proca9 9 #e c4c4 ( wat]1 add #b drops ( dilute hydro*loric acid & #b drops ( sodium nitrite solution 7#aj p] c5t47 & mix ) a solution ( #j4b gm4 ( betanaph?ol 9 #aj c4c4 ( sodium hydroxid solution 7#aj p] c5t474 ,a sc>let r$ precipitate is ?r[n d[n4 ,to a solution ( ab\t #j4a gm4 ( proca9 9 #e c4c4 ( wat] add #c drops ( dilute sulphuric acid & mix ) #e drops ( potassium p]manganate te/ solution4 ,! violet color ( ! latt] disappe>s imm$iately 7di/9ction f coca974 ,dissolve ab\t #j4a gm4 proca9 9 #a c4c4 sulphuric acid ,u4 ,s4 ,p4 ,! solution is colorless 7organic impurities74 ,dissolve #j4a gm4 ( ! salt 9 #aj c4c4 ( wat] & saturate ) hydrog5 sulphid4 ,no coloration or precipitation occurs 7salts ( ! heavy metals74 ,inc9]ate ab\t #j4e gm4 ( proca9 accurately weigh$4 ,n m ?an #j4a p] c5t4 ( residue rema9s4 ,to obta9 specim5s repres5t+ ! m>ket supply1 ord]s = ! ?ree br&s ( proca9 7 plac$ ) ph>maceutical firms 9 ,new ,york1 ,baltimore & ,san ,francisco4 ,! ,baltimore & ,san ,francisco firms suppli$ specim5s ( proca9-novoca9 br& & proca9-,rector br& b report$ t ! ,abbott br& 0 n procurable4 ,! ,new ,york correspond5t 0 able to supply proca9-,rector only4 ,z ! entire output ( ! ,abbott ,laboratories 0 /at$ to g to ! gov]nm5t1 specim5s ( ?is product 7 obta9$ ?r\gh ! surgeon-g5]al ( ! army f ! g5]al pur*as+ (fice1 ,m$ical ,dept41 ,u4 ,s4 ,army4 ,! foll[+ specim5s 7 obta9$ & exam9$3 #a4 ,proca9-,abbott1 #f specim5s3 ,! fir/ specim5 bore no s]ial numb] b ! five lat] specim5s 7 designat$ respectively1 ,no4 #hiiii1 ,no4 #hiiih1 ,no4 #hiiig1 ,no4 #hiiif1 & ,no4 #hajiie1 repres5t+ bat*es f :i* %ipm5ts are to be made on contracts plac$ by ! g5]al pur*as+ (fice1 ,m$ical ,dep>tm5t1 ,u4 ,s4 ,army1 ) ! ,abbott ,laboratories ( ,*icago4 #b4 ,proca9-novoca9 br&1 #d specim5s3 ,^! 7 designat$ respectively1 ,a#ef1 ,a#eg1 ,a#fc1 & ,a#fg4 ,! fir/ two specim5s 7 label$ 8,manufactur$ by ! ,f>bw]ke-,hoe*/ ,co4 at ! ,h4 ,a4 ,metz ,laboratories40 ,! ?ird specim5 7n 9 orig9al conta9]7 0 label$ 8,h4 ,a4 ,metz ,laboratories0 & ! f\r? 0 m>k$ 8,manufactur$ by ! ,h4 ,a4 ,metz ,laboratories40 #c4 ,proca9-,rector1 #c specim5s3 ,ea* bore ! /atem5t 8,manufactur$ by ! ,rector ,*emical ,company0 b _h no 8lot numb]40 ,f ?is exam9ation x appe>s t all ! specim5s ( proca9 receiv$ compli$ satisfactorily ) all te/s ( id5tity & purity ) ! foll[+ exceptions3 7#a7 ,"o specim5 ( proca9-,abbott _h a melt+ po9t slightly bel[ ! p]mitt$ range2 h[ev]1 ! la/ five specim5s _h ! requir$ melt+ po9t4 7#b7 ,five specim5s ( proca9-,abbott & ! la/ ?ree specim5s ( proca9-,rector 7 n entirely colorless1 b _h a yell[ or light br[n t+e4 ,! toxicity exp]im5ts1 :i* 7 c>ri$ out by ,dr4 ,r4 ,a4 ,hat*] ( ! ,cornell ,ph>macologic ,laboratory1 7 report$ z be+ satisfactory4 ,:5 ! ,c\ncil on ,ph>macy & ,*emi/ry ref]r$ ! matt] ( ! discolor$ specim5s ( proca9 to ! ,rector ,*emical ,company = explanation1 ! firm wrote t = a %ort "t = "s unexpla9able reason its proca9 _h be5 slightly yell[i% 9 color1 b t e bat* _h be5 c>efully te/$ & f\nd to answ] all *emical requirem5ts4 ,! firm /at$ t ! product :i* x _h s5t out = "s "t pa/ _h be5 :ite & yield$ a colorless solution4 ,to a l inquiry f ! ,c\ncil ! ,abbott ,laboratories repli$ t ! five samples :i* 7 f\nd discolor$ 7 products manufactur$ by ! ,rector ,*emical ,company & repres5t$ goods :i* x _h pur*as$ to assi/ 9 fill+ delay$ ord]s1 because ! firm _h f\nd itself unable to keep pace ) ! dem& on acc\nt ( delay 9 secur+ ne$$ app>atus4 ,! firm submitt$ protocols to %[ t ! proca9 made by x1 by ,rector & by ,metz 7 ( equal toxicity4 ,9 ! accompany+ table ! results ( ! exam9ation are giv54 ,= comp>ison ! f9d+s = ! specim5s exam9$ previ\sly are includ$4 ,date ,melt+ ,a% ,br& ,receiv$ ,color ,po9t1 ,c4 ,proca9 7,abbott71 f ,committee on ,syn!tic ,drugs #ab_/ba_/ag ,:ite #aed-aee ,none ,proca9 7,abbott71 submitt$ to ,c\ncil ,p4 & ,c #a_/bi_/ah ,:ite #aec4e-aed4e ,none ,proca9 7,abbott71 ,g54 ,pur4 ,(f4 ,u4 ,s4 ,army #h_/ca_/ah ,:ite #aeb4e-aec4e ,none ,proca9 7,abbott71 ,g54 ,pur4 ,slight ,(f4 ,u4 ,s4 ,army1 ,no4 #hiiii #i_/cj_/ah br[ni% #aec4e-aed4e ,none t9t ,proca9 7,abbott71 ,g54 ,pur4 ,slight ,(f4 ,u4 ,s4 ,army1 ,no4 #hiiih #i_/cj_/ah br[ni% #aec-aed4e #j4jje t9t ,proca9 7,abbott71 ,g54 ,pur4 ,slight ,(f4 ,u4 ,s4 ,army1 ,no4 #hiiig #aj_/ #h_/ah br[ni% #aec-aed ,none t9t ,proca9 7,abbott71 ,g54 ,pur4 ,slight ,(f4 ,u4 ,s4 ,army1 ,no4 #hiiif #aa_/ #d_/ah br[ni% #aec4e-aed4e ,none t9t ,proca9 7,abbott71 ,g54 ,pur4 ,slight ,(f4 ,u4 ,s4 ,army1 ,no4 #hajiie #aa_/ #d_/ah br[ni% #aec4e-aed4e ,none t9t ,proca9 7,f>bw]ke ,hoe*/ ,co471 submitt$ to ,c\ncil #aj_/bd_/ag ,:ite #aec-aed ,none ,proca9 7,f>bw]ke ,hoe*/ ,co471 submitt$ to ,c\ncil #ab_/aj_/ag ,:ite #aec-aed4e ,none ,proca9 7,f>bw]ke ,hoe*/ ,co471 submitt$ to ,c\ncil1 m>ket spec4 8,a#ef0 #h_/ #i_/ah ,:ite #aec4e-aed4e ,none ,proca9 7,f>bw]ke ,hoe*/ ,co471 submitt$ to ,c\ncil1 m>ket spec4 8,a#eg0 #i_/ #i_/ah ,:ite #aec4e-aed4e ,none ,proca9 7,h4 ,a4 ,metz ,lab471 m>ket spec4 8,a#fc0 #h_/bc_/ah ,:ite #aec-aed ,none ,proca9 7,h4 ,a4 ,metz ,lab471 m>ket spec4 8,a#fg0 #i_/bc_/ah ,:ite #aec-aed #j4jah ,proca9 7,rector71 f ,com4 on ,syn!tic ,drugs #ab_/ah_/ag ,:ite #aec-aed4e ,none ,proca9 7,rector71 m>ket ,slight spec4 #h_/bj_/ah br[ni% #aec-aee ,none t9t ,proca9 7,rector71 m>ket ,slight spec4 #h_/bc_/ah br[ni% #aec-aee ,none t9t ,proca9 7,rector71 m>ket ,slight spec4 #h_/bc_/ah br[ni% #aec-aed4e ,none t9t ---------------------------------------- ---------------------------- ,s f> z ! evid5ce goes1 !re 0 no?+ to indicate t ! yell[i% or br[ni% color$ specim5s ( proca9 7 s]i\sly impure4 ,on ! contr>y1 ! compliance ) ! *emical & toxicologic te/s indicat$ t ! color 0 due to an insignificant trace ( "s color$ sub/ance produc$ 9 ! manufactur+ process4 ,9 view ( ?is1 ! ,c\ncil consid]$ ! use ( ! discolor$ product to be ju/ifi$ 9 ! pres5t em]g5cy1 al?\gh x urg$ t ! future supply ( proca9 %\ld be free f color & also comply to ! te/s ( purity4 ,x made ?is reque/ 9 ! int]e/ ( ! m$ical & d5tal pr(essions1 :i* use ! drug1 & also 9 a desire t 9 ! manufacture ( syn!tic drugs1 ! ,unit$ ,/ates %\ld occupy a high place4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #aa1 #aiai1 ) additions47 ,,det]ioration ,,( ,,sodium ,,hypo*lorite ,,solutions 78,*lor9at$ ,soda0 ,solutions7 ,! foll[+ note on two hypo*lorite solutions is publi%$ z a slight addition to ! inconclusive available in=mation conc]n+ ! rate ( det]ioration ( solutions conta9+ sodium hypo*lorite3 ,hyclorite4--,?is is a solution ( *lor9at$ soda1 #ajj gm4 ( :i* is said to conta9 sodium hypo*lorite #d4je gm41 sodium *lorid #c4bj gm41 calcium hydroxid #j4be gm41 in]t +r$i5ts #j4ib gm4 ,x is decl>$ to conta91 :5 plac$ on ! m>ket1 n less ?an #c4he p] c5t4 ( available *lor91 & to det]iorate at ! rate ( ab\t #ab p] c5t4 p] ye>4 ,9 ord] t ! available *lor9 cont5t at ! "t ( use may be judg$1 ! date ( bottl+ is /amp$ on ea* package4 ,! solution is prep>$ by decompos+ *lor9at$ lime susp5d$ 9 wat] ) sodium c>bonate & add+ to ! solution obta9$ a fre%ly prep>$ solution ( electrolyz$ sodium *lorid4 ,! composition & keep+ qualities ( hyclorite 7 report$ on by ?is laboratory 7,ann4 ,rep4 ,*em4 ,lab41 ,a4 ,m4 ,a4 #i3abc1 #aiaf74 ,hyclorite is fully describ$ 9 ,new & ,non(ficial ,rem$ies1 #aiah1 p4 #aec4 ,to fur!r *eck ! keep+ qualities ( hyclorite1 a specim5 receiv$ f ! manufactur] 9 ,june1 #aiah1 & said to h be5 bottl$ 9 ,april1 #aiah1 0 exam9$ 9 ,septemb]1 #aiah4 ,x 0 f\nd to conta9 #c4f p] c5t1 8available *lor90 7equival5t to #c4gi gm4 sodium hypo*lorite 9 #ajj gm474 ,?is indicat$ a loss ( #f4b p] c5t4 dur+ five mon?s 7equival5t to #ad4i p] c5t4 p] ye>7 on ! assumption t x conta9$ ! am\nt ( 8available *lor90 decl>$ on ! label4 ,conc5trat$ ,solution ,sodium ,hypo*lorite-,mul=d4--,?is is describ$ z a #e p] c5t1 aque\s solution ( sodium hypo*lorite conta9+ free *lor9 equival5t to f #j4b to #a p] c5t4 sodium hypo*lorite4 ,x is prep>$ by treat+ a solution ( sodium c>bonate & sodium bic>bonate ) *lor9at$ lime4 ,! solution is filt]$ & /&>diz$ by det]m9+ ! 8available *lor90 & adju/+ x to conta9 ! equival5t ( #e p] c5t4 ( sodium hypo*lorite4 ,x is propos$ = use 9 ! irrigation treatm5t ( infect$ w\nds aft] dilution ) n9e times its volume ( wat] & ! addition ( a det]m9$ am\nt 7/at$ on ! label ( ea* bottle7 ( boric acid to r5d] x neutral to ph5olph?ale94 ,! manufactur] has f\nd t developm5t ( a r$ color 7due to =mation ( p]manganate f ! manganese conta9$ 9 ! *lor9at$ lime7 is indicative ( det]ioration1 & !re=e w>ns aga9/ any solution :i* has become p9k4 ,a specim5 ( conc5trat$ solution ( sodium hypo*lorite-,mul=d 0 s5t ! ,c\ncil on ,ph>macy & ,*emi/ry 9 ,june1 #aiag1 ) a view ( hav+ ! product admitt$ to ,new & ,non(ficial ,rem$ies4 ,at t "t x 0 f\nd to conta9 #d4ah p] c5t4 8available *lor90 7equival5t to #d4d gm4 sodium hypo*lorite 9 #ajj gm474 ,ano!r specim5 receiv$ at ! same "t & kept unop5$ 9 a d>k place1 0 exam9$ 9 ,septemb]1 #aiah1 & 0 f\nd to conta9 #b4hh p] c5t4 available *lor9 7equival5t to #c gm4 sodium hypo*lorite p] #ajj gm474 ,on ! assumption t ! second specim5 conta9$1 at ! "t ( its receipt1 ! am\nt ( 8available *lor90 f\nd 9 ! fir/1 ?is second specim5 lo/ #ca p] c5t4 ( its 8available *lor90 dur+ fifte5 mon?s4 ,at ! "t ! specim5s 7 receiv$ f ! ,mul=d ,company1 ! firm report$ exp]im5ts :i* 7 "u way to det]m9e ! keep+ qualities ( ! solution4 ,^! exp]im5ts indicat$ m>k$ det]ioration ( ! specim5s1 :i* _h become r$ f p]manganate =mation1 & also t "o specim51 :i* _h n become r$1 _h lo/ #e p] c5t4 ( its available *lor9 9 "o mon?4 ,! ,mul=d ,company expla9$ t :5 suffici5t data _h be5 accumulat$1 a decision w\ld be made ei!r z to plac+ a "t limit on ! solution or mak+ a claim z to ! rate ( det]ioration4 ,:5 ! extreme det]ioration f\nd by ?is laboratory 0 report$ to ! ,mul=d ,company1 ! firm repli$ t ?is 0 a mu* great] loss ?an ! av]age det]ioration f\nd 9 its *emical laboratory1 namely1 an av]age ( #aj or #ab p] c5t4 p] ye>4 ,x advis$ t because ( ! in/ability ( conc5trat$ solution ( sodium hypo*lorite1 its manufacture _h be5 discont9u$4--7,f ,reports ,a4 ,m4 ,a4 ,*emical ,laboratory1 #aiah1 p4 #ha47 ,,syphilodol ,! %ortage ( arsph5am9 7salv>san7 has made ! sale ( sub/itutes a pr(itable bus9ess4 ,9 _m ( ^! sub/itutes ! e>m>ks ( di%one/y h be5 obvi\s1 s t detection ( _! falsity 0 relatively simple4 ,9 ! case ( 8,syphilodol0 m>ket$ by ! ,fr5* ,m$ic9al ,company1 ,inc41 ,new ,york1 ! deception has be5 practic$ m skilfully4 ,9 ! circul> ann\nc+ _! prep>ations1 we read3 8,x seems fitt+ at ?is "t1 :5 ! ,am]ican physicians are do+ s mu* = ,france1 t !re %\ld be a reciprocation 9 "s way4 8,attempt+ to enhance some:at ?is mutual int]*ange1 we are pres5t+ "s ( ^? sci5tific products1 :i* h be5 s successfully us$ 9 ,france1 ----0 8,! effect ( ,,syphilodol is v simil> to salv>san & neosalv>san1 b x has ! advantage ( be+ m la/+ 9 its results & m pleas+ 9 ! mann] ( its prep>ations1 9 t x is put up 9 ! =m ( tablets1 &1 also1 9 h]metically clos$ glass syr+es or ampules1 s t x may be adm9i/]$ ei!r by ! m\?1 intrav5\sly or intramuscul>ly1 at ! discretion ( ! physician4 ,pati5ts av]se to ! use ( ! hypod]mic ne$le may be treat$ exp$iti\sly by ! use ( ! tablet =m ( ! m$ic9e40 ,9 addition to ,syphilodol1 ! ,fr5* ,m$ic9al ,co4 also sells 8,vi*i ,fruti10 a comb9ation ( salts1 8,urodol10 an 8alkal9e salt ( ! fam\s ,european ,spr+s :i* is not$ = break+ up & dissolv+ uric acid rapidly0 & 8,syloiodol10 8,fr5* ,prev5tive10 :i* is describ$ z 8a solution ( iodol incorporat$ into b\gie40 8,syphilodol10 we are told1 is 8a syn!tic *emical product ( silv]1 ars5ic & antimony1 sci5tifically prep>$ aft] ! =mula ( ! late ,dr4 ,alfr$ ,f\rni] ( ,p>is40 7,italics ours--,ed474 ,x is also claim$ t 8,pr(4 ,met*nik(f & o!r not$ ,fr5* sci5ti/s h made exhau/ive te/s ( syphilodol & f\nd x sup]ior to ! o!r products1 9 ! treatm5t ( syphilis40 ,9 ! adv]tisem5ts1 ,f\rni] & ,met*nik(f are ! only names giv5 ( alleg$ endors]s2 bo? ( ^! m5 are dead & _c prote/4 ,true1 ,f\rni] did consid]able "w on a legitimate syn!tic ( antimony1 silv] & ars5ic hav+ a g5]al *emical con/itution simil> to arsph5am91 b s f> z we are aw>e1 !re has be5 no publication by ^! m5 on 8,syphilodol40 ,x w\ld seem t ! valuable "w & high reputation ( ,f\rni] & ,met*nik(f are be+ capitaliz$ by ! ,fr5* ,m$ic9al ,company 9 _! endeavor to foi/ a no/rum on ! m$ical pr(ession ( ?is c\ntry4 8,syphilodol0 comes 9 two =ms--ampules & tablets4 ,an ord] = two #j4d ampules br\ght an elaborate case1 mu* l ^? us$ to hold ! popul> /yle safety razors4 ,! ampule itself 0 a 8classy0 affair evid5tly made by a glass exp]t2 ! hypod]mic ne$le 0 enclos$ 9 a novel seal$ glass device4 ,! price ( ea* ampule is #c4 ,no su* fancy g>ni%m5ts came ) ! tablets1 al?\gh !y are li/$ at #d4ej = tw5ty-five--#ah c5ts a tablet6 ,9 ! 8,syphilodol0 adv]tis+ x is emphasiz$ t bo? ! tablets & ampules are to be adm9i/]$4 ,= example3 8,syphilodol is disp5s$ 9 ! =m ( tablets & also h]metically clos$ glass syr+es or ampules s t x may be us$ ei!r by ! m\?1 intrav5\sly or intramuscul>ly at ! discretion ( ! physician4 ,an advantage ( ! tablets is t !y c & %\ld be giv5 dur+ ! int]im betwe5 ! injections40 ,,laboratory ,,report ,,on ,,syphilodol ,sev]al samples ( 8,syphilodol0 7 s5t to ! ,am]ican ,m$ical ,association ,*emical ,laboratory by read]s ( ,! ,j\rnal4 ,an orig9al bottle ( tablets 0 ord]$ direct f ! ,fr5* ,m$ic9al ,company4 ,! bottle conta9$ #be yell[ tablets1 hav+ an av]age weight ( #j4bgf gm4 7#d-a_/d gra9s74 ,aft] be+ p[d]$1 8,syphilodol0 0 f\nd to be only p>tially soluble 9 wat] 7! excipi5t is soluble7 & to be neutral 9 reaction4 ,^! f9d+s contradict ! claims on ! circul> accompany+ ! bottle to ! effect t 8,syphilodol is a yell[ p[d]1 soluble 9 wat]1 & has an acid reaction40 ,qualitative te/s indicat$ ! pres5ce ( m]cury1 sucrose 7cane sug>71 iodid1 calcium1 sulphate1 fatty mat]ial1 a trace ( silv]1 a trace ( ars5ic & a v m9ute trace ( antimony2 a r$ dye 0 also pres5t4 ,bo? qualitative & quantitative data %[$ t ! m]cury 0 pres5t 9 ! =m ( m]cur\s iodid 7yell[ iodid ( m]cury--hydr>gyri iodidum flavum74 ,quantitative e/imations yield$ ! foll[+3 ,silv] 7,ag7 #j4jja p] c5t4 ,m]cury 7,hg7 #aa4a p] c5t4 ,iodid 7,i-7 #g4h p] c5t4 ,sucrose 7cane sug>7 #gb4j p] c5t4 ,a% 7calcium sulphate7 #b4e p] c5t4 ,e!r-soluble mat]ial 7fatty mat]ial--petrolatum7 #c4e p] c5t4 ,?us ea* tablet ( 8,syphilodol0 conta9s approximately1 #c_/d gra9 ( m]cur\s iodid4 ,an ampule ( 8,syphilodol10 label$ #j4d gram1 conta9$ approximately #a4e c4c4 ( a liquid :i* aft] evaporation on a wat]-ba? left a residue weigh+ #j4h mg41 or #a_/hj gra94 ,a second ampule held ab\t #b c4c4 ( liquid1 :i* conta9$ a trace ( ars5ic 7less ?an #j4jjjja gm41 or #a_/fjjj gra972 a v small am\nt ( m]cury 0 indicat$ b n def9itely e/abli%$4 ,! liquid _h ! physical *>act]i/ics ( wat]4 ,accompany+ 8,syphilodol0 adv]tis+ s5t to physicians is a circul> lett] invit+ ! doctor to become a memb] 9 ! 8,unit$ ,/ates ,bact]iological & ,rese>* ,in/itute40 ,! 8in/itute0 seems to be a means ( sugge/+ t ! physician h bact]iologic1 pa?ologic & s]ologic exam9ations made on behalf ( 8 pati5ts4 ,9 view ( ! fact t x is to ! comm]cial int]e/ ( ! ,fr5* ,m$ic9al ,company to h z _m us]s ( 8,syphilodol0 z possible1 x w\ld be int]e/+ to "k :at proportion ( ! ,wass]mann te/s are report$ negative4 ,%orn ( its my/]y1 ,syphilodol ! 8syn!tic *emical product ( silv]1 ars5ic & antimony0 is ess5tially m]cur\s iodid--yell[ iodid ( m]cury4 ,details ( ,analysis ,,syphilodol ,,tablets ,9 ,france !re has be5 on ! m>ket = "s "t a syn!tic comp\nd ( silv]1 ars5ic & antimony hav+ ! g5]al /ructure ( arsph5am94 ,/ructurally1 ! =mula z giv5 by ,bon>d1 ,danyss & ,t\rni] is 7,c,h,n,z7 #b;,ag,br,sb,o 7,h,,s7--dioxy diam9o ars5ob5sol/ibicosilv] sulphate4 ,z ! adv]tis+ matt] = 8,syphilodol0 ref]r$ to ! syn!tic comp\nd ( silv]1 antimony & ars5ic1 & also to its use 9 syphilis by ,f\rni]1 ! above comp\nd 0 fir/ suspect$4 ,h[ev]1 ! g5]al *>act]i/ics ( syphilodol tablets1 su* z p>tial solubility 9 wat]1 b n soluble 9 sodium hydroxid1 sodium bic>bonate or acids1 ?rew d\bt on ! hypo!sis4 ,:5 a small am\nt ( ! p[d]$ tablets 0 treat$ ) wat]1 a yell[ residue c\ld be filt]$ (f2 ! filtrate 0 p9k1 opalesc5t1 :i* on /&+ gave a cle> p9k solution1 & a small yell[ precipitate4 ,! residue1 :5 all[$ to rema9 9 sulphuric acid solution 7#bj p] c5t47 ov] night became r$2 on boil+1 ! r$ precipitate ) sulphuric acid1 ! precipitate volatiliz$ & c\ld be cond5s$ 9 a wat* glass4 ,add+ a p9* ( manganese dioxid to ! hot sulphuric acid mixture caus$ an evolution ( iod9 fumes4 ,a small am\nt ( p[d]$ syphilodol tablets 0 plac$ 9 ! sunlight2 !y turn$ f yell[ to black4 ,all ^! reactions are typical ( m]cur\s iodid--yell[ iodid ( m]cury4 ,,m]cury1 ,,silv]1 ,,ars5ic1 ,,antimony ,i4 ,m]cury4--,two me?ods 7 us$ to det]m9e ! m]cury3 7a7 #a4dece gm4 ( p[d]$ syphilodol 0 treat$ ) #aj c4c4 ( a #ej p] c5t4 sodium sulphid solution4 ,! solution 0 !n transf]r$ ) wa%+s 7ab\t #bj c4c47 to a ca?ode cup1 previ\sly weigh$ ) its conta9$ m]cury4 ,! m]cury comp\nd 0 electrolyz$ by a curr5t ( ab\t #h volts & #c amp]es1 us+ a rotat+ anode4 ,! solution 7& "s sulphur susp5sion7 0 remov$ by siphon1 p\r+ 9 wat] until ! amp]age ( ! curr5t 0 close to z]o 7,u4 ,s4 ,p41 ,,ix1 p4 #ehg74 ,! increas$ weight 9 m]cury 0 #j4afab gm4 ,,ii4 ,to s]ve z a *eck on ! =ego+ me?od1 m]cury 0 also det]m9$ 9 ! foll[+ me?od1 :i* also all[$ sy/ematic te/s = silv]1 antimony & ars5ic4 7b7 #a4ajbc gm4 ( ! sample 0 plac$ 9 an ,erl5mey] flask1 #ej c4c4 ( wat]1 #ej c4c4 ( sodium hydroxid solution 7#aj p] c5t47 & #bj c4c4 ( =maldehyd solution1 ,u4 ,s4 ,p41 add$4 ,! solution 0 boil$ = t5 m9utes & ma9ta9$ at temp]ature ( /eam ba? = two h\rs4 7,?is r$uces ! m]cury salt to m]cury & any silv] salt to silv]2 antimony w\ld probably be likewise r$uc$47 ,! precipitat$ m]cury 0 transf]r$ by wat]1 & conc5trat$ nitric acid add$4 7,! nitric acid solution is boil$ to oxidize all m]cur\s nitrate to m]curic nitrate47 ,a small :ite precipitate 0 obta9$ at ?is po9t :i* seem$ to be insoluble 9 aqua regia 7calcium sulphate74 ,! filtrate f ?is precipitate1 :i* 0 wa%$ well1 0 te/$ ) "o or two drops ( dilute hydro*loric acid & a fa9t precipitate =m$2 ?is 0 filt]$ (f ?r\gh extra f9e filt] pap] & wa%$ repeat$ly4 ,! pap] & precipitate 0 heat$ ) potassium cyanid solution ov] night1 filt]$ & ! filtrate electrolyz$ 9 a plat9um di%4 ,! increase 9 weight ( ! di% 0 #j4jjjah gm41 or #j4jja p] c5t4 ,into ! plat9um di% "s nitric acid 0 p\r$1 !n dilut$1 & a drop ( hydro*loric acid add$4 ,a turbidity 0 produc$ :i* cle>$ on ! addition ( excess ( ammonium hydroxid solution 7silv]74 ,! filtrate f ! nitric acid treatm5t 0 electrolyz$1 ?is "t 9 a plat9um di%1 & ! liquid c>efully remov$1 wa%$ c>efully ) r$i/ill$ alcohol & e!r4 ,! m]cury1 :i* c\ld be se5 easily by ! nak$ eye1 weigh$ #j4abjj gm41 equival5t to #aj4hi p] c5t4 ( m]cury4 ,,iii4 ,ars5ic & ,antimony4--,ab\t #c gm4 ( ! p[d]$ specim5 0 dige/$ ) sulphuric acid 9 a ,kjeldahl flask4 ,"o-half portion 7:i* 0 evaporat$ almo/ to dryness & treat$ ) #e c4c4 ( conc5trat$ hydro*loric acid7 0 submitt$ to treatm5t ) hydrog5 sulphid1 dilut$1 & saturat$ ) hydrog5 sulphid4 ,! precipitate 0 treat$ 9 ! usual mann] ( ! gr\p sep>ation ) w>m ammonium sulphid solution4 ,! filtrate f ?is treatm5t 0 acidulat$ ) hydro*loric acid1 ! precipitate remov$1 & treat$ ) conc5trat$ hydro*loric acid4 ,! sub/ance insoluble 9 hydro*loric acid 0 treat$ ) m conc5trat$ hydro*loric acid & a cry/al ( potassium *lorate4 ,! solution 0 te/$ aft] ! ,gutzeit me?od ( ! ,ph>macopeia ,,ix1 = ars5ic4 ,a v small am\nt 0 indicat$4 ,! hydrog5 sulphid te/ 0 n indicative4 ,! solution :i* might conta9 ! antimony 0 te/$ ) hydrog5 sulphid4 ,9 "o case only 0 a slight orange coloration produc$4 ,no antimony 0 deposit$ on plat9um foil 9 ! pres5ce ( granulat$ z9c4 ,^! te/s 7 run 9 triplicate4 ,iodid4--,iodid 0 det]m9$ by ! ,c>ius me?od 7a7 #j4gdab gm4 yield$ #j4aaab gm4 silv] iodid1 equival5t to #h4ji p] c5t42 7b7 #j4ecai gm4 yield$ #j4jgea gm41 equival5t to #g4hj p] c5t4 ,! iodid & m]cury 7 9 proportions comp>able to m]cur\s iodid4 ,a%4--7a7 #j4iaei gm4 :5 ignit$ to con/ant weight yield$ #j4jbcb gm41 equival5t to #b4eb p] c5t4 a%2 7b7 #a4cjjh gm4 treat$ ) wat] & ! residue filt]$ on a ,goo* filt] & ignit$4 ,! a% ( ! residue 0 #b4ea p] c5t4 7! m]cur\s iodid volatiliz$74 ,! a% 0 calcium sulphate4 ,sucrose4--#a4cjjh gm4 ( ! sample 0 treat$ ) wat] & filt]$ by suction ?r\gh a ,goo* crucible4 ,! filtrate & wa%+ 7 c>efully transf]r$ to #ejj c4c4 volumetric flask1 & all[$ to /& "o week2 #ej c4c4 portions 7 us$ to det]m9e sug> accord+ to ! ,daufresne-,o',sullivan me?od4 ,! weights ( cupric oxid av]ag$ #baj mg41 or #gb p] c5t4 ,e!r ,soluble ,mat]ial4--#a4fiih gm4 ( ! p[d]$ specim5 0 extract$ ) e!r & ! e!r extract evaporat$ to dryness4 ,! residue weigh$ #j4jfjj gm41 equival5t to #c4ec p] c5t4 ,,syphilodol ,,ampules ,wat]4--,! liquid f "o ampule 0 di/ill$ ov] v c>efully4 ,! freez+ po9t ( ! liquid 0 #j4a ,c41 & x 0 neutral to me?yl orange & ph5olph?ale94 ,ars5ic4--,! cont5ts ( "o ampule 0 plac$ 9 a small flor5ce flask1 #bj c4c4 ( conc5trat$ sulphuric acid add$ & heat$ to #gj ,c42 #j4e gm4 ( potassium p]manganate 0 add$ 9 small am\nts4 ,! proc$ure 0 !n c>ri$ on z describ$ by ,engelh>dt & ,w9t]s 9 ,j4 ,am4 ,ph>m4 ,assn41 #aiae1 p4 #adfi4 ,to ! mixture f #e to #aj c4c4 ( hydrog5 p]oxid solution 7 add$ drop by drop until ! color _h disappe>$4 ,! liquid 0 dilut$ ) #bj c4c4 ( wat]1 boil$ fifte5 m9utes1 dilut$ aga9 & boil$ fifte5 m9utes1 !n cool$ & made up to exactly #ajj c4c4 ,a blank 0 also run alongside4 ,five c4c4 ( ?is solution 0 !n te/$ quantitatively = ars5ic accord+ to ! ,u4 ,s4 ,p4 ,,ix me?od1 us+ all precautions4 ,comp>isons ( /a9s %[$ less ?an #j4jjjja gm4 ( ars5ic 7,z74--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,may #ah1 #aiah47 ,,c]el5e ,c]el5e1 a p>aff9 prep>ation = ! treatm5t ( burns1 0 submitt$ to ! ,c\ncil by ! ,holliday ,laboratories1 ) ! /atem5t t x 0 compos$ ( #hd p] c5t4 p>aff91 #ae p] c5t4 myricyl palmitate1 & #a p] c5t4 purifi$ elemi gum to :i* is add$ oil ( eucalyptus #b p] c5t4 & betanaph?ol #j4be p] c5t4 ,x 0 expla9$3 8,myricyl ,palmitate is a purifi$ =m ( ,beeswax1 free f all impurities1 acids1 etc41 :i* is solely manufactur$ by ?is ,company44440 ,x 0 also /at$ t on 8special ord]0 ,c]el5e has be5 made conta9+ oil ( eucalyptus & resorc91 oil ( eucalyptus & picric acid1 & picric acid alone4 ,! foll[+ report on ! prep>ation 0 pres5t$ to ! ,c\ncil by ! ref]ee to :om ,c]el5e _h be5 assign$3 ,c]el5e is ano!r comp\nd wax = ! treatm5t ( burns4 ,accord+ to ! "w ( ,sollmann 7,j4 ,a4 ,m4 ,a4 #fh3agii1 #aiag7 x is highly improbable t comp\nd mixtures h any advantage ov] simple p>aff9 ( l[ melt+ po9t4 ,c]el5e mu/ !re=e be consid]$ z an uness5tial modification ( p>aff91 & z 9 conflict ) ,rule #aj1 unless def9ite evid5ce ( sup]iority be submitt$4 ,c]el5e mixtures conta9+ m$ic9al +r$i5ts also appe> unsci5tific s9ce ! evid5ce t ! +r$i5ts d n leave ! wax has n be5 successfully contradict$4 ,f9ally1 ! claims made = ,c]el5e are r extreme1 & w\ld ne$ "s revision be=e !y c\ld be accept$4 ,! ,a4 ,m4 ,a4 ,*emical ,laboratory reports3 ,! physical prop]ties ( ,c]el5e are z foll[s3 ,melt+ po9t by ,u4 ,s4 ,p4 me?od #ej4j ,c4 ,ductility limit #cj4e ,c4 ,pla/icity limit #bf4d ,c4 ,n /rong at #ch4j ,c4 ,adh]es mod]ately well2 deta*es ) 8pull+40 ,on heat+1 readily loses eucalyptol1 & a small am\nt ( res9\s sub/ance =ms 9 ! bottom ( ! beak]4 ,if ,c]el5e be heat$ to #ade ,c4 & cool$1 ! result+ product no long] has ! prop]ties ( ! orig9al ,c]el5e4 ,aft] two ye>s' delay on ! "p ( ! manufactur]1 ! ,c\ncil au?oriz$ publication decl>+ ,c]el5e inadmissible = ,new & ,non(ficial ,rem$ies because its sup]iority ov] s+le p>aff9s _h n be5 demon/rat$ & ! unw>rant$ claims _h n be5 ab&on$4--7,ab/ract$ f ,! ,j\rnal ,a4 ,m4 ,a41 ,feb4 #ae1 #aiai47 ,,dr4 ,,de ,,sanctis' ,,rheumatic ,,& ,,g\t ,,pills ,dr4 ,de,sanctis' ,rheumatic & ,g\t ,pills are sold by ,edw>d ,cleav]1 #ac ,cl]k5well ,road1 ,london1 ,engl&4 ,! ,am]ican ag5ts are ,e4 ,f\g]a & ,co41 ,inc41 ,new ,york4 ,! package is a r\nd pill box & conta9s twelve pills & a circul>1 :i* directs t "o pill be tak5 e eight h\rs until reliev$4 ,9 ! package !re is also a circul> adv]tis+ ,dr4 ,de,sanctis' ,g\t & ,rheumatic ,pa9t1 ) directions = its use4 ,on ! cov] ( a box1 :i* conta9$ six ( ! retail packages1 is ! /atem5t t ^! pills h be5 9 g5]al use = ne>ly #ajj ye>s1 & t _! sale has be5 built up )\t adv]tis+4 ,de,sanctis' pills are r\nd1 uncoat$1 & h a light br[n color4 ,!re 0 "s v>iation 9 ! color ( diff]5t lots1 "o lot 9 p>ticul> be+ gray r ?an br[n4 ,a little arr[root />* 0 f\nd 9 ea* box1 ?is evid5tly hav+ be5 us$ z a du/+ p[d]4 ,! pills 7 v h>d1 r brittle1 b q difficult to p[d]4 ,! pills 7 n readily dis9tegrat$ by wat] or dilut$ acids1 ev5 :5 w>m$1 b :5 w>m$ ) a dilute sodium hydroxid solution !y readily dis9tegrat$4 ,t5 pills weigh$ #c4bac gm41 an av]age ( #j4cbac gm41 or #e gra9s4 ,! arr[root />* us$ z a du/+ p[d] 0 remov$ z completely z possible by roll+ ! pills 9 a clo?4 ,sev]al doz5 pills 7 !n p[d]$ & ! p[d] ?us obta9$ us$ = ! analysis4 ,a microscopic exam9ation ( ! p[d] %[$ p[d]$ col*icum se$ 9 abundance & also traces ( arr[root />*1 no d\bt f t us$ z ! du/+ p[d]4 ,s9ce col*icum se$ 0 s abundant1 ! p[d] 0 assay$ by ! ,u4 ,s4 ,ph>macopeial me?od = col*icum se$ 7,u4 ,s4 ,p4 ,,ix1 p4 #abj71 slightly modifi$ s t less ( ! p[d]$ pills ?an direct$ !re c\ld be us$4 ,9 "o assay #c4ge gm4 gave #j4jbjd gm4 ( col*ic9 or #j4ed p] c5t4 ,9 a duplicate1 #e gm4 gave #j4jbcd gm4 ( col*ic9 or #j4dg p] c5t42 av]age #j4e p] c5t4 ,! alkaloid obta9$ _h ! *>act]i/ic appe>ance & odor ( col*ic9 :5 sep>at$ f ! se$ "u ^! conditions4 ,! solution 9 wat] & acid 0 yell[2 ! aque\s solution 0 int5sely bitt]1 & ! yell[ color int5sifi$ ) acids4 ,! dry residue became int5sely yell[ ) conc5trat$ sulphuric acid2 ) nitric acid x became violet turn+ to yell[1 & ) conc5trat$ sulphuric acid & potassium nitrate x gave a yell[i% gre5 color1 turn+ to violet & f9ally to a w9e color4 ,all ^! reactions are typical ( col*ic94 ,f #a gm4 ( ! p[d]$ pills !re 0 obta9$ #j4jdbe gm4 ( a%1 or #d4be p] c5t4 ,:5 ! p[d]$ pills 7 extract$ ) *lor(orm 9 a ,soxhlet app>atus1 a v uni=m quantity ( extract 0 obta9$4 ,f #e gm4 !re 0 obta9$1 9 "o case1 #j4eha gm42 9 ano!r1 #j4egee gm41 & 9 a ?ird1 #j4ehh gm41 ! av]age be+ #j4ehae gm4 or #aa4fc p] c5t4 ,on /ill fur!r extract+ ) alcohol1 a small am\nt ( extractive 0 obta9$1 ! am\nt dep5d+ on ! l5g? ( "t ! extraction 0 cont9u$4 ,on extract+ ) hot wat] ! residue left aft] exhau/ion ) *lor(orm & ) alcohol1 a fur!r extract 0 obta9$4 ,9 "o case1 x am\nt$ to #j4dgfc gm4 or #i4ec p] c5t41 & 9 ano!r case x am\nt$ to #j4dgj gm41 or #i4dj p] c5t42 av]age #i4dg p] c5t4 ,9 attempt+ to dry ! pills or ! above-m5tion$ *lor(ormic extract at #ajj ,c41 a cry/all9e sublimate 0 obta9$ :i* _h ! odor ( b5zoic acid4 ,! cry/als 7 acid1 _! neutral solution gave a fle%-color$ precipitate ) f]ric *lorid1 & !y melt$ at #abj-aba ,c4 ,?is cry/all9e sub/ance appe>$ to be b5zoic acid4 ,! quantity ( b5zoic acid 9 ?is extract 0 det]m9$ by heat+ x to ab\t #adj ,c4 ,a curr5t ( air 0 drawn ?r\gh ! flask & ! sublim$ b5zoic acid collect$ 9 a cool$ tube4 ,! b5zoic acid 0 wa%$ out ( ! tube ) neutral alcohol1 & ! solution 0 titrat$ ) t5? normal potassium hydroxid4 ,9 "o case1 #aa4be c4c4 ( t5?-normal alkali 0 us$1 indicat+ #j4acgc gm1 ( b5zoic acid2 9 ano!r1 #ab4bg c4c41 indicat+ #j4adih gm4 ( b5zoic acid2 av]age #j4adcf gm41 or #b4hg p] c5t4 ,9 a ?ird case ! temp]ature rea*$ #bej ,c41 & !re 0 "s decomposition ( ! fat 9 ! flask & "s color$ mat]ial di/ill$ ov]4 ,= ?is sublimate #ae4ed c4c4 ( t5?-normal alkali 7 requir$4 ,aft] evaporat+ ! alcohol & acidulat+ ! solutions obta9$ 9 ! previ\s exp]im5ts1 ! b5zoic acid 0 extract$ ) *lor(orm4 ,9 ! fir/ case1 #j4achc gm4 0 obta9$2 9 ! second1 #j4aeda gm42 av]age #j4adfb gm41 or #b4ib p] c5t4 ( b5zoic acid4 ,:5 ! orig9al *lor(ormic extract 0 heat$ until all ( ! b5zoic acid _h be5 driv5 (f1 ! residue _h ! appe>ance ( a semisolid fat4 ,x comp>$ q closely 9 color1 odor1 etc41 ) ! fatty mat]ial obta9$ by extract+ col*icum se$ ) *lor(orm1 al?\gh ! odor 0 m sugge/ive ( oleic or /e>ic acid4 ,x 0 di/9ctly acid1 :i* is also true ( ! fatty mat]ial obta9$ f a sample ( col*icum se$4 ,! extract obta9$ ) hot wat] 0 light yell[2 gummy1 at fir/1 b dri$ to a glass-l brittle mass4 ,x _h a slight burn$-sug> odor & ta/e1 & 0 neutral 9 reaction4 ,x 0 /rongly dextrogyrate & at once r$uc$ ,fehl+'s solution z well z alkal9e silv] nitrate solution4 ,on boil+ ) potassium hydroxid solution1 x turn$ deep r$4 ,x also gave ! ,molis* c>bohydrate reaction1 & ! ozazone te/ 9 sev5te5 m9utes z describ$ 9 ,mullik5 7,id5tification ( ,pure ,organic ,comp\nds1 ,ed4 #a1 #aije1 p4 #bf74 ,^! are all *>act]i/ic reactions ( lactose or milk sug>4 ,f ?is exam9ation we conclude t ,de,sanctis' pills conta9 p[d]$ col*icum se$1 b5zoic acid1 & sug> ( milk4 ,!re is also pres5t fatty mat]ial :i* resembles ! fat ( col*icum se$1 b may be1 9 "p1 add$ fatty acid4 ,! p]c5tage ( col*ic9 f\nd 7#j4ej7 is ab\t t ( a good quality ( col*icum se$1 ! ,u4 ,s4 ,ph>macopeial /&>d be+ n less ?an #j4de p] c5t4 ,s9ce ! pills conta9 mat]ial o!r ?an col*icum se$1 ?is assay w\ld indicate a col*icum se$ ( high alkaloidal cont5t1 or ! possible re9=cem5t ( ! pills ) col*icum extract or col*ic94 ,! am\nt ( b5zoic acid1 #b4ib p] c5t41 or ab\t #a_/g gra9 p] pill1 is insignificant f a !rapeutic /&po9t1 s9ce an av]age dose is #j4e gm41 or #h gra9s4 ,fatty acids1 & ! fatty matt] f col*icum se$ are in]t1 at lea/ 9 ! quantities f\nd "h4 ,! only (fice :i* fatty acids might p]=m1 w\ld be to give ! pills an ent]ic quality1 prev5t+ _! absorption until !y rea* ! inte/9e4 ,! sug> ( milk1 ab\t #aj p] c5t41 or #a_/b gra9 p] pill1 no d\bt is simply an excipi5t4 ,de,sanctis' pills are !re=e ess5tially #e gra9 doses ( p[d]$ col*icum se$1 ( :i* ! av]age dose is #j4b gm41 or #c gra9s 7,u4 ,s4 ,p4 ,,ix1 p4 #abj74 ,! ,j\rnal 9 pres5t+ ! facts conta9$ 9 ! above report made ! foll[+ comm5ts3 8,"h !n1 we h sold = self-m$ication an extremely poison\s drug1 ) no w>n+ ( ! risk ! public runs 9 us+ x4 ,:ile ! directions call = 8"o pill e eight h\rs until reliev$10 x is notori\s t ! public takes ! attitude t[>d 8pat5t m$ic9es0 t1 if a little is good1 m is bett]1 & ! av]age us] ( rem$ies = self-treatm5t is likely1 unless !re is "s w>n+1 to use 8 own discretion z to ! am\nt tak54 8,! individual dose is above t ( ! av]age recomm5d$ 9 ! ,unit$ ,/ates ,ph>macopeia4 ,col*icum or its alkaloids--or = t matt]1 any drug z toxic z col*icum--h no place 9 prep>ations ( ! home-rem$y type4 ,9 ! case ( all 8pat5t m$ic9es10 public int]e/ dem&s t ! full quantitative =mula ( ! !rapeutically active +r$i5ts %\ld be giv5 on ! label1 = :5 ! public prescribes = itself1 x has a "r to "k :at x is tak+4 ,un=tunately1 public int]e/ cla%es ) ve/$ int]e/s &1 z usual1 ve/$ int]e/s get ! bett] ( x4 ,9 ! case ( su* dang]\s prep>ations z ,de,sanctis' pills1 if _! sale is to be p]mitt$ at all1 n only %\ld ! names & quantities ( all !rapeutically active +r$i5ts 9 ! mixture be giv51 b ! law %\ld require t ! ^w ,poison be pla9ly pr9t$ on ! label40--7,ab/ract$ f ,! ,j\rnal ,a4 ,m4 ,a41 ,july #ai1 #aiai47 ,,iodex ,,& ,,liquid ,,iodex ,! ,a4 ,m4 ,a4 ,*emical ,laboratory exam9$ ,iodex 9 #aiae4bac ,! claims made1 at t "t1 by ! exploit]s1 ,m5ley ,james1 7 %[n to be contr>y to facts 9 t ,iodex conta9$ only traces ( free iod9 :ile !y claim$ 8#e p] c5t4 ,!rapeutically ,free ,iod940 ,ev5 ! total quantity ( iod9 0 %[n to be only ab\t "o half ( ! #e p] c5t4 claim$ to be pres5t z free iod94 #bac ,annual ,reports ( ! ,*em4 ,lab4 ( ! ,a4 ,m4 ,a41 #aiae1 p4 #hi4 ,an exam9ation ( ! adv]tis+ matt] s5t out by ,m5ley ,james 9 #aiai %[$ t sub/antially ! same claims 7 be+ made z 9 #aiae4 ,?is at once sugge/$ ! inquiry3 ,s9ce ! claims are ! same z previ\sly made1 h ! manufactur]s alt]$ ! composition to con=m to ! claims8 ,! answ] is f\nd 9 ! results ( ! analysis ( two samples pur*as$ 9 ! op5 m>ket e>ly 9 #aiai4 ,?is analysis %[s conclusively t ,iodex is ess5tially ! same z 9 #aiae1 t is1 t x conta9s no free iod9 & only ab\t ?ree fif?s ( ! total am\nt ( iod9 claim$4 ,x w\ld seem t ,iodex 7,ung4 ,iodi41 ,m4 ,j47 is 9 obvi\s conflict ) ,section #g ( ! ,food & ,drugs ,act4 ,:ile x is sold "u a "n recogniz$ by ! ,u4 ,s4 ,ph>macopeia1 namely1 ,ung4 ,iodi41 x does n con=m to ! /&>ds ( ! ,u4 ,s4 ,ph>macopeia = t product4 ,iod9 o9tm5t ,u4 ,s4 ,p4 is made ) #d p] c5t4 ( free iod91 #d p] c5t4 ( potassium iodid1 #ab p] c5t4 ( glyc]91 & a b5zo9at$ l>d base4 ,x %\ld !n conta9 approximately #g p] c5t4 ( total iod94 ,x has be5 %[n by ,w>r5#bad t ab\t #ge p] c5t4 ( ! iod9 9 ! ,u4 ,s4 ,p4 o9tm5t rema9s 9 ! free /ate ev5 aft] mon?s ( /&+4 ,ung4 ,iodi41 ,u4 ,s4 ,p41 !n1 %\ld conta9 ab\t #c p] c5t4 ( free iod94 ,iodex conta9s no free iod91 or b traces1 & no potassium iodid4 ,fur!rmore1 ! ,iodex label decl>es ! pres5ce ( #e p] c5t4 ( 8!rapeutically free0 iod94 ,z a matt] ( fact1 ! am\nt ( iod9 is v>iable1 ! highe/ am\nt f\nd be+ #c4e p] c5t4 & samples conta9+ z l[ z #b4fc p] c5t4 h be5 exam9$4 #bad ,w>r51 ,l4 ,e43 ,iod9 ,o9tm5t1 ,am4 ,j4 ,ph>m41 ,augu/1 #aiag1 p4 #cci4 ,x w\ld seem fur!r t ,iodex is misbr&$ "u ! ,%]ley am5dm5t 9 t x is said t x 8may be us$ ext]nally ) advantage 9 all cases :]e ! action ( iod9 is desir$40 ,s9ce x conta9s no iod9 z su* ?is _c possibly be true4 ,x is also /at$ 9 a circul> accompany+ ! trade package t 8,?irty m9utes aft] inunction iod9 c be f\nd 9 ! ur9e40 ,?is /atem5t has also be5 %[n to be untrue4--7,annual ,reports ,a4 ,m4 ,a4 ,*em4 ,lab41 #aiae1 p4 #hi47 ,details ( ,analysis ,iodex4--,?is is a r s(t o9tm5t1 almo/ black b ) a decid$ gre5i% ca/ 9 ?9 lay]s4 ,x is soluble 9 *lor(orm b is only p>tly saponifi$ & dissolv$ by alcoholic potassium hydroxid4 ,iodex has a di/9ct odor l oleic acid4 ,free ,iod94--,:5 exam9$ by ! me?od previ\sly us$#bae only m9ute traces ( free iod9 7 f\nd4 #bae ,ibid41 p4 #ij4 ,total ,iod94--,! me?ods employ$ 7 z foll[s3 #a4 ,iodex 0 saponifi$ by boil+ = f two to ?ree h\rs ) alcoholic potassium hydroxid4 ,! alcohol 0 !n evaporat$ & ! iod9 det]m9$ by ! me?od describ$ 9 ! ,u4 ,s4 ,ph>macopeia = ?ymol iodid4 #b4 ,! same z ,me?od #a1 except t aft] ignition ( ! saponifi$ mixture ! halog5 0 det]m9$ by weigh+ z silv] iodid4 #c4 ,! ,c>ius me?od4 ,x %\ld be not$ t ,me?ods #b & #c det]m9e *lor9 & brom9 %\ld any be pres5t ) ! iod94 ,:5 #e gm4 ( ,sample #a 0 assay$ by ,me?od #a1 x requir$ #gc4ef c4c4 ( t5?-normal sodium ?iosulphate1 equival5t to #c4aa p] c5t4 ( iod94 ,9 a duplicate1 #b4gefe gm4 ( ,iodex requir$ #ch c4c4 ( t5?-normal sodium ?iosulphate1 equival5t to #b4ib p] c5t4 ( iod92 av]age ( ! two1 #c4jb p] c5t4 ( iod94 ,a weight ( #b4ehjj gm4 ( ,sample #a1 assay$ by ,me?od #b1 gave #j4aehb gm4 ( silv] halid1 equival5t to #j4jhee gm4 ( iod91 or #c4ca p] c5t4 ,a weight ( #j4ehh gm4 ( ,sample #b1 assay$ by ! ,c>ius me?od1 gave #j4jchh gm4 ( silv] halid1 indicat+ #j4jbjif gm4 ( iod91 or #c4eb p] c5t4 ,9 a duplicate1 #j4ecdb gm4 gave #j4jcch gm4 ( silv] halid1 indicat+ #j4jahbf gm4 ( iod91 or #c4db p] c5t42 av]age1 #c4di p] c5t4 ( iod94 ,liquid ,iodex4--,?is is sold by ,m5ley ,james1 ,ltd41 ! firm sell+ ,iodex ,o9tm5t4 ,accord+ to a circul> 9 a trade package 8! valuable prop]ties ( ,free ,iod9e are available 9 ,liquid #8,iodex' 9 a /ate ( greatly enhanc$ activity2 b ! irritat+1 corrosive & h>d5+ drawbacks ( ord9>y solutions ( ! drug are abs5t40 ,! label on a bottle reads z foll[s3 8,liquid #8,iodex' 7,liq4 ,iodi4 ,m4 ,j474 ,a nonirritant prep>ation ( iod9e 7#b-a_/b7 444 ,?is product conta9s ,free ,iod9e44440 ,! sample ( ,liquid ,iodex pur*as$ on ! op5 m>ket 0 f\nd to be a r$di% liquid ) an odor l oleic acid4 ,x dissolv$ completely 9 *lor(orm4 ,free ,iod94--,a weight ( #f4bicf gm4 0 dissolv$ 9 *lor(orm & ! solution %ak5 ) #be c4c4 ( a solution ( potassium iodid4 ,! iod9 :i* pass$ into ! potassium iodid solution 0 titrat$ ) t5?-normal sodium ?iosulphate1 #j4ha c4c4 be+ requir$4 ,?is indicates #j4jajbb gm4 ( iod91 or #j4af p] c5t4 ,total ,iod94--,total iod9 0 det]m9$ by ,me?od #a z giv5 above "u ,iodex4 ,a weight ( #d4dff gm4 requir$ #cb4ic c4c4 ( t5?-normal sodium ?iosulphate1 equival5t to #j4jfifd gm4 ( iod91 or #a4ee p] c5t4 ,9 a duplicate1 #e gm4 ( mat]ial requir$ #cc4c c4c4 ( t5?-normal sodium ?iosulphate1 equival5t to #j4gjdc gm4 ( iod91 or #a4da p] c5t42 av]age1 #a4dh p] c5t4 ( iod94 ,liquid ,iodex1 !n1 conta9s b little 7#j4af p] c5t47 free iod9 & only ab\t ?ree fif?s ( ! total iod9 claim$4 ,i4 ,g4 ,o4 ,i4 ,g4 ,o4 is an iod9 o9tm5t4 ,x is said to be made by ,dr4 ,h4 ,s4 ,lambd91 ,p]u1 ,kansas4 ,9 a circul> di/ribut$ by ! manufactur]1 x is /at$ t 8,i4 ,g4 ,o4 is a saturat$ solution ( ,iod9e ,gas 9 petrolatum at #acj degrees ) oil ( eucalyptus4 ,! heat ( ! body lib]ates ! iod9e & x is absorb$ z free iod9e40 ,a sample ( ,i4 ,g4 ,o41 receiv$ f a physician1 0 exam9$4 ,x 0 f\nd to be a black o9tm5t1 gre5 9 ?9 lay]s1 ) a slight odor l crude petroleum4 ,by ! me?ods us$ = ! exam9ation ( ,iodex1 ,i4 ,g4 ,o4 0 f\nd to conta9 #j4ei p] c5t4 ( free iod94--7,f ,reports ,a4 ,m4 ,a4 ,*emical ,laboratory1 #aiai1 p4 #ajd47 ,,iod9 ,,9 ,,liquid ,,petrolatum ,a4 ,h4 ,cl>k1 ,ph4,g41 ,sc4,b4 ,( all ! ?+s us$ 9 m$ic9e no?+ seems to h attract$ ! att5tion ( all classes ( us]s z has iod94 ,p]haps m romantic s*emes = ! cure ( all ! ills :i* afflict mank9d h c5t]$ 9 iod9 !rapy ?an 9 any o!r "o drug4 ,iod9 is be+ us$ 9 e conceivable way f cry/als to colloid2 9 vapor2 comb9$ z iodid1 iodate & ! l2 organic1 inorganic1 simple & complex2 int]nal1 ext]nal & by injection1 & yet !re seems to be no end to ! +5i\s s*emes = its exploitation4 ,"o ( ^! s*emes1 & "o s simple t x seems at fir/ sight to be h>dly wor? s]i\s consid]ation1 is t ( a solution ( iod9 9 liquid petrolatum4 ,solutions ( ?is k9d h frequ5tly be5 (f]$ to physicians & ! laity4 ,! ?+ ( p>ticul> int]e/ is ! claim made z to ! p]c5tage ( free iod94 ,five p] c5t4 is frequ5tly claim$4 ,exam9ation ( "s ( ^! products 9 ! *emical laboratory ( ! ,a4 ,m4 ,a4#baf reveal$ ! fact t !y did n conta9 ! claim$ am\nt ( free iod94 ,^! que/ions at once arose3 ,0 ! l[ free iod9 cont5t due to int5tional fraud1 ! result ( c>elessness1 or ( ignorance8 ,0 x impossible to prep>e a solution conta9+ #e p] c5t41 or did ! iod9 sl[ly comb9e ) ! oil & disappe>8 #baf ,reports ,a4 ,m4 ,a4 ,*emical ,laboratory1 #aiae1 p4 #ajf2 ,ibid41 #aiag1 p4 #hg4 ,sev]al ye>s ago ! ,a4 ,m4 ,a4 ,*emical ,laboratory#bag conduct$ "s exp]im5ts on ! solubility ( iod9 9 liquid petrolatum1 :i* indicat$ t a saturat$ solution w\ld conta9 ab\t #a4d p] c5t4 ,^! exp]im5ts did n %[ conclusively t no iod9 0 absorb$ by ! petrolatum dur+ ! process ( solution4 ,= ?is reason1 fur!r exp]im5ts 7 conduct$ ) ! view ( det]m9+ bo? ! solubility 9 & ! ext5t to :i* iod9 is absorb$ 7disappe>s z free iod971 if at all1 by liquid petrolatums ( v>i\s k9ds4 ,!oretically su* hydroc>bons %\ld n absorb iod94 ,! results ( ^! exp]im5ts are "h giv54 #bag ,ibid41 #aiag1 p4 #hg4 ,a sample ( iod9 0 prep>$ by sublimation f a mixture ) potassium iodid4 ,?is sample :5 dri$ ov] sulphuric acid assay$ #ii4ih p] c5t4 ( iod94 ,portions ( ?is sample 7 us$ 9 all ( ! subsequ5t exp]im5ts4 ,to prep>e solutions ( def9ite conc5trations1 9 all cases express$ z p]c5tage by weight1 an accurately weigh$ quantity ( iod9 0 plac$ 9 a glass-/opp]$ bottle & an accurately weigh$ quantity ( liquid petrolatum add$4 ,! mixture 0 subject$ to treatm5t z indicat$ 9 ! v>i\s exp]im5ts & f ! weights ( iod9 & petrolatum us$ ! p]c5tage ( iod9 0 calculat$4 ,! me?od ( assay employ$ 0 z foll[s3 ,a weigh$ quantity ( ! iod9 solution 0 transf]r$ to a bottle or flask by means ( sev]al small am\nts ( *lor(orm1 ab\t #ej c4c4 9 all4 ,to ?is 0 add$ ab\t #be c4c4 ( potassium iodid solution4 ,! mixture 0 !n titrat$ ) t5?-normal sodium ?iosulphate until on ?or\gh %ak+ no iod9 pass$ into ! aque\s lay]4 ,to #b4abdh gm4 ( iod9 0 add$ #aii4c gm4 ( liquid petrolatum4 ,! mixture 0 %ak5 frequ5tly ea* day & aft] =ty days !re seem$ to be /ill a few p>ticles ( iod9 undissolv$4 ,! sup]natant solution 0 assay$1 h[ev]1 & f\nd to conta9 #a4jch p] c5t4 ( iod94 ,! iod9 add$ 0 #a4jee p] c5t4 ,six mon?s lat] #a4jbe p] c5t4 ( iod9 0 f\nd4 ,to #e4ahcb gm4 ( iod9 0 add$ #aii4e gm4 ( liquid petrolatum4 ,! mixture 0 heat$ to #ajj ,c4 = f\r h\rs ) frequ5t %ak+4 ,! iod9 0 9 p]fect solution4 ,! p] c5t4 ( iod9 w\ld !n be #d4ie4 ,^u cool+1 iod9 9 abundance cry/alliz$ out4 ,aft] /&+ a few h\rs1 ) frequ5t %ak+1 ! iod9 9 solution 0 det]m9$4 ,?is 0 f\nd to be #a4dbe p] c5t4 ,^! two exp]im5ts indicate3 ,fir/1 t ! previ\s f9d+s ( ! ,a4 ,m4 ,a4 ,*emical ,laboratory are correct 9 t only ab\t #a4d p] c5t4 ( free iod9 is reta9$ 9 solution 9 liquid petrolatum at room temp]ature4 ,second1 t ! quantity ( iod9 absorb$ by liquid petrolatum at room temp]ature1 9 sev5 mon?s at lea/1 is practically none4 ,?ird1 t iod9 dissolves r sl[ly 9 liquid petrolatum at room temp]ature4 ,9 ! exp]im5ts1 ! results ( :i* are tabulat$ bel[1 ! iod9 & liquid petrolatum 7 heat$ at #ajj ,c4 = ab\t f\r h\rs1 %ak+ frequ5tly to ha/5 solution4 ,aft] cool+1 ! specim5s 7 assay$ & 7 aga9 assay$ at int]vals z indicat$ 9 ! table4 ,date ( ,p] ,p] ,k9d ( ,manufac- ,weight ,p] ,p] ,c5t4 ,c5t4 ,liquid ture & ,c5t4 ,c5t4 ,iod9 ,iod9 ,petrolatum ,fir/ ,iod9 ,petrolatum ,iod9 ,iod9 ,nov4 #ag1 ,nov4 #ai1 ,us$ ,assay ,us$ ,f\nd #aiah #aiai ,/anol9d #aj_/ag_/ah #b4jhi #ahh4d #a4jif #a4jhe #a4jfh #a4jfg ,squibb #aj_/ad_/ah #a4iefi #ahf4gh #a4jcjf #a4jbcb #a4jac #a4jji ,unkn[n1 bulk99 #aj_/bh_/ah #a4idig #aeh4b #a4bbe #a4acc #a4jge #a4jie ,p>ke1 ,davis #aj_/bd_/ah #b4jhfi #afg4dc #a4bda #a4bdhh #a4aia #a4ahj ,co 99 ,consid]able d>k s$im5t =m$ 9 ?is sample dur+ ! heat+ process4 ,x %\ld be po9t$ out "h t :ile e sample %[$ "s absorption1 ! am\nt1 ) ! exception ( ! unkn[n bulk1 is s small t x might ev5 be acc\nt$ = on ! basis ( 8exp]im5tal error40 ,e ord9>y precaution 0 tak5 to insure accuracy1 b s9ce ab\t #ae gm4 ( ! solution 0 us$ = ea* det]m9ation1 x is se5 t an error ( #j4c c4c4 9 ! titration w\ld indicate a great] absorption ( iod9 ?an t not$4 ,conclusions3 ,^! exp]im5ts %[3 ,a solution ( iod9 9 liquid petrolatum is saturat$ :5 x conta9s ab\t #a4d p] c5t4 ( iod94 ,! am\nt ( iod9 absorb$ 7disappe>+ z free iod97 by liquid petrolatum1 :5 9 contact at room temp]ature = z long z sev5 mon?s1 or 9 contact at #ajj ,c4 = f\r h\rs1 or bo?1 is relatively insignificant4 ,also all ! absorption seems to take place dur+ ! heat+ & 9 ! fir/ mon? ( contact4--7,f ,reports ,a4 ,m4 ,a4 ,*emical ,laboratory1 #aiai1 p4 #ba47 ,,am]ican-,,made ,,syn!tic ,,drugs--,,ii ,exam9ation ( ,proca9 7,novoca971 ,b>bital 7,v]onal71 ,ph5etidyl- ,acetph5etid9 7,holoca971 ,c9*oph5 or ,ph5ylc9*on9ic ,acid 7,atophan71 ,manufactur$ ,"u ,f$]al ,trade ,commission ,lic5ses,g ,paul ,ni*olas ,lee*1 ,ph4,d42 ,william ,rabak1 ,ph4,g41 ,sc4,b41 & ,a4 ,h4 ,cl>k1 ,ph4,g41 ,sc4,b4 ,g ,f ! ,*emical ,laboratory ( ! ,am]ican ,m$ical ,association4 ,g ,! fir/ article ( ?is s]ies dealt ) ! purity ( acetylsalicylic acid4 ,lee*1 ,p4 ,n43 ,exam9ation ( ,am]ican-,made ,acetylsalicylic ,acid1 ,j4 ,indu/4 ,eng94 ,*em41 ,april1 #aiah1 p4 #bhh4 8,:at's 9 a ,"n80 ibid41 p4 #bee4 ,acetylsalicylic ,acid1 or 8,:at's 9 a ,"n80 ,editorial1 ,j4 ,a4 ,m4 ,a4 #gj3 #ajig 7,april #ac7 #aiah4 ,be=e ,european ho/ilities1 ! ,unit$ ,/ates 0 s dep5d5t on ,g]many = syn!tic drugs t ! dep5d5ce 0 consid]$ a necessity2 ?is 0 /rik+ly manife/$ by ! precipit\s rise 9 prices imm$iately aft] ! emb>go 0 decl>$ aga9/ ,g]many4 ,s9ce !n ! %ortage ( ,g]man-made syn!tics has caus$ two important results3 #a4 ,! physician c d )\t mo/ ( ! ,g]man drugs1 because ! prew> dem& _h be5 /imulat$ artificially4 #b4 ,^? few syn!tics1 :i* 7 9 great ne$1 are be+ rapidly replac$ by ! ,am]ican-made drugs4#bah ,9 connection ) ! second result1 ! ,*emical ,laboratory ( ! ,am]ican ,m$ical ,association has endeavor$ to contribute its s]vices4 #bah ,/ieglitz1 ,julius3 ,syn!tic ,drugs ,,ii1 ,j4 ,a4 ,m4 ,a4 #gj3 #fhh 7,m>* #i7 #aiah4 ,lee*1 ,p4 ,n43 ,! ,v9dication ( ! ,am]ican ,*emi/2 ,syn!tic ,drugs1 ,*icago ,*em4 ,bull4 ,janu>y1 #aiah1 p4 #bcj4 ,9 ,septemb]1 #aiag1 x 0 ann\nc$#bai t ! ,a4 ,m4 ,a4 ,*emical ,laboratory w\ld make /udies ( ,am]ican-made syn!tics4 ,j prior to ?is ann\ncem5t1 ! ,national ,rese>* ,c\ncil e/abli%$ a committee on syn!tic drugs#bbj 8to facilitate ! manufacture ( syn!tic drugs 9 ?is c\ntry & ?us to relieve %ortage & r$uce ! exorbitant prices :i* h result$ f ! w>40#bba ,also dur+ ?is "t ,congress 0 consid]+ ! 8trad+ ) enemy0 act1 fir/ kn[n z ! ,adamson bill--! purpose ( :i* 0 to conf] au?ority on ! ,presid5t to lic5se ,am]ican firms to use ,u4 ,s4 pat5ts own$ by ,g]man subjects4 ,! act became law1 ,septemb] #bh2 ! ,f$]al ,trade ,commission 0 designat$ by ! ,presid5t to c>ry out ! provisions ( ! law z x ref]r$ to enemy-own$ pat5ts4 ,z a result ( a conf]5ce1 ,oct4 #cj1 #aiag1bbb ) v>i\s ag5cies1 ! ,f$]al ,trade ,commission decid$ to consid] lic5ses = manufactur]s ( syn!tic drugs1 aft] recomm5dations _h be5 made by ! ,committee on ,syn!tic ,drugs ( ! ,national ,rese>* ,c\ncil2 ?is committee 9 turn invok$ ! aid ( ! ,a4 ,m4 ,a4 ,*emical ,laboratory 9 te/+ ! manufactur]'s products4 ,! ess5ce ( ! laboratory's "w up to ,july #a1 #aiai1 is report$ 9 ?is pap]4 #bai ,! ,quality ( ,am]ican-,made ,syn!tics1 ,j4 ,a4 ,m4 ,a4 #fi3 #ajah 7,sept4 #bb7 #aiag4 #bbj ,?is committee is compos$ ( ,julius ,/ieglitz1 *airman1 pr(essor ( *emi/ry1 ,univ]sity ( ,*icago2 ,w4 ,a4 ,puckn]1 secret>y ( ! ,c\ncil on ,ph>macy & ,*emi/ry1 ,am]ican ,m$ical ,association1 & ,moses ,gomb]g1 pr(essor ( *emi/ry1 ,univ]sity ( ,mi*igan4 #bba ,/ieglitz1 ,julius3 ,%ortage ( ,syn!tic ,rem$ies1 ,j4 ,a4 ,m4 ,a4 #fi3 #djj 7,aug4 #d7 #aiag4 #bbb ,=eign ,pat5ts to ,be ,op5 to ,am]ican ,manufactur]s1 ,j4 ,a4 ,m4 ,a4 #fi3 #aeej 7,nov4 #c7 #aiag4 ,,! ,,nam+ ,,( ,,lic5s$ ,,drugs 8,p>tly 9 ord] to help insure to lic5sees a m>ket = _! products aft] ! w>1 9 l>g] "p inspir$ by ! idea ( enc\rag+ ! e/abli%m5t ( a p]man5t ,am]ican indu/ry 9 ^! important articles1 ! ,f$]al ,trade ,commission wisely decid$ t ,am]ican h\ses %\ld be put on ! same foot+ z compet+ =eign h\ses = aft]-!-w> competition1 by impos+ on all lic5sees ! obligation to use new (ficial names = ! articles1 names :i* aft] ! w> w be op5 to all competitors1 dome/ic & =eign40#bbc #bbc ,= an int]e/+ discussion1 see ,/ieglitz1 ,julius3 ,syn!tic ,drugs1 ,j4 ,a4 ,m4 ,a4 #gj3 #ecf 7,feb4 #bc72 #fhh 7,m>* #i72 #ibc 7,m>* #cj7 #aiah4 ,brack51 ,l4 ,l43 ,f$]al ,trade ,commission ,reque/s ,use ( ,(ficial ,names1 ibid4 #gj3 #eeh 7,feb4 #bc7 #aiah4 ,! new ,am]ican names are3 ,arsph5am9#bbd 7contract$ f ! sci5tific "n ars5ph5olam97 = salv>san1 ars5ob5zol1 di>sanol1 arsam9ol4 #bbd ,! te/+ & /&>diz+ ( arsph5am9 is be+ done by ! ,hygi5ic ,laboratory1 ,u4 ,s4 ,public ,heal? ,s]vice4 ,= *emical te/s see repr9t #dgb1 ,public ,heal? ,reports4 ,= a review ( ! pat5t lit]ature see article by ,h4 ,f4 ,lewis1 ,j4 ,indu/4 ,eng94 ,*em41 ,feb4 #a1 #aiai1 p4 #ada4 ,b>bital 7contract$ f ! sci5tific "n die?yl-b>bituric acid7 = v]onal4 ,b>bital-sodium 7! sodium salt ( b>bital7 = 8v]onal-sodium0 & 8m$9al40 ,c9*oph5 = atophan or ph5ylc9*on9ic acid 7! ,u4 ,s4 ,p4 ,,ix "n74 ,proca9 = novoca9 hydro*lorid 7f 8pro0 & 87co7ca9e074 ,proca9 nitrate = novoca9 nitrate4 ,,exam9ation ,,( ,,syn!tic ,,drugs ,9 te/+ *emically ! products :i* _h be5 submitt$ to ! ,f$]al ,trade ,commission1 ! aims 7 t ! product %\ld con=m to a high degree ( purity2 at ! same "t ! c&idate = lic5se %\ld n be inflict$ ) undue h>d%ips 9 mak+ ! product1 su* z an unnecess>ily high degree ( purity4 ,x 0 insi/$ t ! purity ( ! drugs %\ld be equal to1 if n great] ?an1 t ( ! respective =m] ,g]man-made products1 9 ord] to uphold ! "n & reputation ( ! ,am]ican manufactur]s 9 ! aft]-!-w> competition4 ,consequ5tly1 9 ! *emical "w ! ,am]ican product 0 always exam9$ p>allel ) ! ,g]man-made product1 au!ntic samples ( ! latt] ( :i* ! laboratory _h 9 its possession4 ,:5ev] possible1 ! te/s describ$ 9 books ( /&>ds 7 c>ri$ out4 ,,b>bital 7,,v]onal7 ,b>bital 0 introduc$ into m$ic9e "u ! propriet>y "n 8v]onal10 & 0 manufactur$ 9 ,g]many by ,fri$r4 ,bay] ,co41 ,lev]kus51 & ,e4 ,m]ck ,co41 ,d>m/adt1 ,g]many4 ,b>bital is describ$ 9 ,new & ,non(ficial ,rem$ies1 #aiai1bbe z die?ylb>bituric acid 7die?ylmalonyl urea7 hav+ ! =mula3 ,,nh--,,co ,c,h _/ _/ ,,oc ,c _/ ,,nh--,,co ,c,h #bbe ,new & ,non(ficial ,rem$ies1 #aiai1 publi%$ by ,! ,c\ncil on ,ph>macy & ,*emi/ry ( ! ,am]ican ,m$ical ,association1 p4 #hb4 ,x is (ficial 9 ! ,briti% ,ph>macopeia "u ! "n 8b>bitone10 & 9 ! ,g]man ,ph>macopeia z 8acidum die?ylb>bituricum40 ,b>bital 8may be prep>$ by ! int]action ( e/]s ( die?ylmalonic acid ) urea 9 ! pres5ce ( metallic alcoholates4444 ,x is also obta9$ by cond5sation ( die?ylcyanacetic e/] ) urea by means ( sodium alcoholate40 ,b>bital is us$ 9 m$ic9e *iefly z a hypnotic4 ,! diff]5t br&s ( b>bital :i* 7 submitt$ to ! laboratory 7 subject$ to ! te/s giv5 9 ! books ref]r$ to above4#bbf ,! products 73 #bbf ,! ph>maceutic monograph on b>bital has be5 omitt$4 ,x 0 publi%$ 9 ! #aiah edition ( ! ,annual ,reports ( ! ,*emical ,laboratory ( ! ,am]ican ,m$ical ,association4 #a4 ,b>bital 7,abbott7 ,sample ,a1 to ,f$]al ,trade ,commission4 #b4 ,b>bital 7,abbott7 ,sample ,b1 to ,f$]al ,trade ,commission4 #c4 ,b>bital 7,abbott7 ,sample ,c1 to ,r$ ,cross4 #d4 ,b>bital 7,anto9e ,*iris71 to ,f$]al ,trade ,commission4 #e4 ,b>bital 7,v4 ,halt]71 to ,f$]al ,trade ,commission4 #f4 ,b>bital 7,rector ,*emical ,company7 to ,f$]al ,trade ,commission4 #g4 ,die?ylb>bituric acid 7,m]ck71 to ,c\ncil4 #h4 8,v]onal10 manufactur$ by ,f>b4 vorm ,fri$4 ,bay] ,co41 ,g]many4 ,all respond$ satisfactorily to ! te/s4 ,9 ,table #a are giv5 ! respective melt+ po9ts & p]c5tages ( a% f\nd4 7,! melt+ po9t ( a mixture ( ! sample ) ! orig9al 8v]onal0 0 always tak547 ,,table #a4--,,melt+ ,,po9t ,a% ,a% #a #ahh4e-ahi4j #j4ja #e #ahh4j-ahh4e #j4ja #b #ahh4e-ahi4j #j4ja #f #ahh4j-ahh4e #j4ja #c #ahh4j-ahh4e #j4ja #g #ahh4j-ahh4e #j4ja #d #ahh4j-ahh4e #j4jd #h #ahh4j-ahh4e #j4jb ,b>bital does n seem to =m an insoluble salt ) *lorplat9ic acid2 nor an e!r-insoluble hydro*lorid or oxalate2 nor an insoluble b>ium salt4 ,x does n respond to _m urea te/s1 & is n affect$ by urease z w\ld be expect$ 9 light ( ! ext5sive inve/igations made on ?is enzyme by ,van ,slyke & ,cull54 ,z b>bital is also sold 9 ! =m ( tablets or mixtures1 a reliable me?od = its quantitative det]m9ation 9 ! pres5ce ( o!r sub/ances is ne$$4 ,"s exp]im5ts 9 ?is direction 7 made1 b ! press ( o!r "w did n p]mit _! cont9uation4 ,:5 "t p]mits1 ?is "w w be resum$4 ,at ! "t ( writ+ ?is article1 lic5ses = manufacture _h be5 grant$ by ! ,f$]al ,trade ,commission to ! ,abbott ,laboratories1 to ,anto9e ,*iris ,company1 & to ! ,rector ,*emical ,company4 ,,b>bital ,,sodium 7,,m$9al ,,or ,,v]onal-,,sodium7 ,b>bital sodium1 =m]ly sold "u ! propriet>y names 8v]onal-sodium0 & 8m$9al10 is1 z ! =m] "n sugge/s1 ! sodium salt ( die?ylb>bituric acid4 ,its !rapeutic advantages are /at$ to be t m rapid results are obta9$ because ( its increas$ solubility ov] b>bital alone4#bbg ,b>bital sodium %\ld yield1 accord+ to !ory1 #aa4ai p] c5t4 ( sodium & #hi4ca p] c5t4 ( die?ylb>bituric acid4 ,a numb] ( ye>s ago1 :5 8v]onal-sodium0 & 8m$9al0 7 be+ introduc$1 ,puckn] & ,hilp]t#bbh f\nd t ^! products yield$ results correspond+ closely to ! !oretical am\nts ( sodium & die?ylb>bituric acid4 ,a rec5t exam9ation ( v]onal-sodium1 ,m]ck1 made = ! ,c\ncil on ,ph>macy & ,*emi/ry1 %[$ x to be ( ! same composition z t previ\sly report$4 #bbg ,new & ,non(ficial ,rem$ies1 #aiah1 p4 #if4 #bbh ,puckn]1 ,w4 ,a41 & ,hilp]t1 ,w4 ,s43 ,v]onal-,sodium & ,m$9al1 ,j4 ,a4 ,m4 ,a4 #eb3caa 7,jan4 #bc7 #aiji2 ,rep4 ,a4 ,m4 ,a4 ,*emical ,lab41 #b3ac4 ,only "o firm's product has be5 submitt$ to ! laboratory ?r\gh ! ,committee on ,syn!tic ,drugs1 b because ( ! unsatisfactory results1 x 0 n recomm5d$ = lic5se1 nor1 z f> z we are aw>e1 has ! firm inve/igat$ its anomalies4#bbi ,! am\nt ( moi/ure 9 ?is specim5 0 #j4jd p] c5t4 ,x yield$ #aj4id & #aj4ig p] c5t1 ( sodium4 ,puckn] & ,hilp]t f\nd #aa4jb p] c5t4 ( sodium 9 8m$9al10 & #aa4ja p] c5t4 ( sodium 9 8v]onal-sodium40 ,! !oretical am\nt1 accord+ to ! =mula giv5 = m$9al by ! proprietors 7,c,h7 ,c,c,o,n,na,c,o,n,h,c,o is #aa4ai p] c5t4 ,:5 an aque\s solution ( b>bital sodium 0 acidifi$1 & ! die?ylb>bituric acid extract$ ) e!r1 x 0 f\nd t !am\nt ( fre$ acid extract$ v>i$ directly ) ! l5g? ( "t aft] acidification4 #bbi ,s9ce ?is 0 writt51 ! ,c\ncil on ,ph>macy & ,*emi/ry has also accept$ 8,b>bital-,sodium ,abbott40 ,x is possible t 9 prep>+ ! sodium salt ( die?ylb>bituric acid1 ! r+ op5s up1 =m+ a comp\nd n s easily affect$ by dilute m9]al acids4 ,,table #b4--;,,extraction ,,( ,a ,,sample ,,( ,,b>bital-,,sodium ,die?ylb>bituric ,acid ,l5g? ( ,"t p] ,c5t4 a4 ,imm$iately #ge4e a#a4 #c_/d h\r #hb4j b4 ,imm$iately #hb4j c4 #a-a_/b h\rs #hj4e d4 #d h\rs #hb4hb e4 #d h\rs #hc4ef f4 #d h\rs #hc4da g4 #de-a_/b h\rs #hd4hi h4 #de-a_/b h\rs #hd4gc ,!ory 44444444 #hi4ca ,v]onal-,sodium 7,puckn] & ,hilp]t7 #hi4ja 7av]age7 ,m$9al 7,puckn] & ,hilp]t7 #hh4ie 7av]age7 ,,ph5etidyl-,,acetph5etid9 ,,hydro*lorid#bcj 7,,holoca9 ,,hydro*lorid7 ,ph5etidyl-acetph5etid9 hydro*lorid 0 introduc$ 9 ! ,unit$ ,/ates "u ! "n ( 8holoca9 hydro*loride0 by ,f>bw]ke1 vorm ,mei/] ,lucius & ,bru5+1 ,hoe*/ a4 ,m4 ,g]many2 ! product app>5tly _h n be5 pat5t$ 9 ?is c\ntry1 al?\gh x 0 protect$ 9 ,g]many "u pat5ts ,no4 #ghhfh & #hjefh4 ,new & ,non(ficial ,rem$ies1 #aiah1 describes 8holoca9 hydro*lorid0 z e!nyl-p>adie?oxy-diph5yl-amid9 hydro*lorid ,,*37,,nc,h,,oc,h77,,nhc,h,,oc,h7,h,cl4 ,x is us$ z a local ane/hetic = ! eye4 #bcj ,no %ort1 sci5tific "n has be5 giv5 = ?is sub/ance al?\gh sev]al are "u consid]ation4 ,! /&>ds1 su* z _h be5 describ$1 7 meag] & unsatisfactory4 ,h5ce :5 ! fir/ specim5 ( ,am]ican-made ph5etidyl-acetph5etid9 0 s5t to ! ,a4 ,m4 ,a4 ,*emical ,laboratory ?r\gh ! ag5cy ( ! ,f$]al ,trade ,commission & ! ,committee on ,syn!tic ,drugs1 x 0 necess>y = ! laboratory to "w out adequate /&>ds4#bca ,z a result ( ! *emical "w1 a r compreh5sive monograph 0 drawn up1 :i* 0 publi%$ 9 ! #aiah ,laboratory ,reports4 ,a summ>y ( ! products exam9$1 ) "s ( ! *emical data1 is giv5 9 ,table #c4 ,x w be se5 t "o specim5 _h a defici5cy ( ab\t #b p] c5t4 ( free base4 #bca ,c]ta9 *emical te/s are describ$ by ,e4 ,h4 ,rank91 ,indian ,j4 ,m4 ,res4 #d3bcg1 #aiaf2 also ,*em4 ,ab/4 #aj3ebd4 ,o!r ref]5ces are ,s*midt3 ,ph>mazeutis*e ,*emie #b3iij1 ,beil/e9 ,,ii1 7#djc74 ,ar5ds1 ,g43 ,neue ,arzneimittel und ph>mazeutis*e ,spezialitt51 ,ed4 #d1 #aiac1 p4 #bga4 ,,table #c4--;,,data ,,on ,,ph5etidyl-,,acetph5etid9 ,,hydro*lorid table split by transcrib] to fit small scre5 ,melt+ ,phosphorus ,manufactur] ,appe>ance ,moi/ure ,po9t ,comp\nds ,ph5etid999 ,john ,t4 ,:ite #e4ac #aia4e to #aib ,abs5t ,negative ,millik5 ,co4 cry/all9e p[d] ,syn!tic ,:ite #b4ij #aib to #aib4e ,abs5t ,negative ,products ,co4 cry/all9e p[d] ,h4 ,a4 ,metz ,:ite #d4ii #aib to #aib4e ,abs5t ,negative ,laboratories1 cry/all9e ,inc4 p[d] ,f>bw]ke- ,slightly #e4ji #aij to #aia ,abs5t ,negative ,hoe*/ ,co4 p9k 7,g]man cry/al specim57 ---------------------------------------- ------------------------------ ,p] ,p] ,p] ,c5t4 ,c5t4 ,c5t4 ,melt+ ,plat9um 9 ,indol ,base by ,base by ,po9t ,plat9um ,manufactur] ,reaction ,a% ,weight ,titration ( ,base ,salt ,john ,t4 ,millik5 ,co4 ,positive #j4jj #hi4af #hi4af #aaf to #aag #ai4jb ,syn!tic ,products ,co4 ,positive #j4ac #hg4di #hg4bf #aaf to #aag #ai4c ,h4 ,a4 ,metz ,laboratories1 ,positive #j4jj #hi4ad #hh4ee #aag #ai4cd ,inc4 ,f>bw]ke- ,hoe*/ ,co4 ,positive #j4af #hi4fe #hi4fd #aaf to #aag #ai4jj 7,g]man specim57 ---------------------------------------- ------------------------------ 99 ,! ph5etid9 te/ is n v s5sitive4 ,! melt+ po9t ( ! free base is giv5 by a numb] ( writ]s at #aba ,c4 ,al?\gh ,k5n]t#bcb /at$ x to be #aag ,c4 & n #aba ,c41 8 f9d+s seem+ly w5t unhe$$4 ,x w be not$ t our "w %[s ! melt+ po9t to be 9 accord ) t ann\nc$ by ,k5n]t4 #bcb ,k5n]t3 ,*em4 ,z5tralbl4 #b3eef1 #ahig4 ,! ,f$]al ,trade ,commission has n issu$ any lic5ses = ! manufacture ( 8holoca9 hydro*lorid40 ,! ,john ,t4 ,millik5 ,company has )drawn its application4 ,! ,h4 ,a4 ,metz ,laboratories 7,successor to ,f>bw]ke ,hoe*/ ,company1 ,new ,york7 are mak+ ! product 9 ?is c\ntry4 ,,c9*oph5 7,,ph5ylc9*on9ic ,,acid1 ,u4 ,s4 ,p42 ,,atophan7 ,c9*oph5 7ph5ylc9*on9ic acid7 0 introduc$ 9 ! ,unit$ ,/ates z a m$ic9e "u ! propriet>y "n 8atophan10 by ,s*]+ & ,glatz1 ,new ,york ,city1 :o be=e ! w> 7 ! ,am]ican ag5ts = ! ,g]man manufactur]s 8,*emis*e ,fabric auf ,acti5 von ,e4 ,s*]+1 ,b]l940 ,ph5ylc9*on9ic acid 7#b ph5yl-qu9ol9-#d c>boxylic acid7 0 fir/ describ$ by ,doebn] & ,gieseke#bcc 9 #ahhg1 :o prep>$ x by w>m+ toge!r pyro-racemic acid1 b5zaldehyd & anil9 9 alcoholic solution2 x has ! /ructural =mula3 ,,cooh ,n #bcc ,doebn] & ,gieseke3 ,ann4 d4 ,*em4 7,liebigs7 #bdj3bia1 #ahhg4 ,! *ief use ( ph5ylc9*on9ic acid is z an antiuric acid ag5t1 especially indicat$ 9 g\t4 ,9 #aiac1 ! ,g]man h\se ( ,s*]+ 0 made ! assignee ( pat5t #ajdegei grant$ by ! ,unit$ ,/ates gov]nm5t#bcd = ! manufacture ( ph5ylc9*on9ic acid3 at ab\t ! same "t ! product 0 admitt$ to ! ,u4 ,s4 ,ph>macopeia ,,ix1 "u v loosely con/ruct$ /&>ds4 #bcd ,! validity ( ?is pat5t is to be d\bt$4 ,"s "t aft] ! beg9n+ ( ! ,european w> ! propriet>y 8atophan0 became sc>ce 9 ,am]ica4 ,9 #aiag1 h[ev]1 ,s*]+ & ,glatz1 ,new ,york1 plac$ ,am]ican-made atophan on ! m>ket & submitt$ x to ! ,c\ncil on ,ph>macy & ,*emi/ry4 ,lat]1 o!r firms began to manufacture ! product & also submitt$ specim5s4 ,dur+ ! "t x 0 inve/igat+ ^! products1 ! ,f$]al ,trade ,commission decid$ t a lic5se 0 ne$$ to manufacture ph5ylc9*on9ic acid "u ! pat5t j ref]r$ to1 s t altoge!r ! laboratory _h a numb] ( specim5s to exam9e4 ,9 mak+ ! exam9ations = ! ,c\ncil1 ! laboratory 0 practically conf9$1 by virtue ( ! ,food & ,drugs ,law1 to limit its requirem5ts ( purity to ^? ( ! ,ph>macopeia4 ,practically1 ! only te/s 7 melt+ po9t1 a% & solubility4 ,accord+ to ! ,u4 ,s4 ,ph>macopeia ! melt+ po9t is 8ab\t #baj40 ,9 ,new & ,non(ficial ,rem$ies1 #aiah1 x 0 expla9$ t atophan 8complies ) ! /&>ds = ph5ylc9*on9ic acid1 ,u4 ,s4 ,p41 b melts betwe5 #bjh & #bab ,c40 ,! ,u4 ,s4 ,ph>macopeia requires t no weighable a% rema9s on inc9]at+ ab\t #j4e gm4 ( ph5ylc9*on9ic acid4 ,consid]able v>iations1 especially 9 melt+ po9ts1 7 f\nd1 z c be se5 f ,table #d4 ,,table #d4--,,melt+ ,,po9ts ,,& ,,a% ,product ,manufactur] ,melt+ ,a%1 ,no4 ,po9t1 ,c4 #a ,abbott ,laboratories1 ,*icago #bjh4e-baj4e #j4je #b ,abbott ,laboratories1 ,*icago #bab-bac #j4je #a ,calco ,*em4 ,co41 ,b\nd ,brook #bji-baj4e #j4jg #a ,morg5/]n1 ,new ,york #bjd4e-bjg4e #b4h #b ,morg5/]n1 ,new ,york #bjh4e-baa4e ,none #a ,s*]+ & ,glatz1 ,new ,york #bjf-bjh ,none #b ,s*]+ & ,glatz1 ,new ,york #bji-baa ,none #c ,s*]+ & ,glatz1 ,new ,york #bjh4e-baj #j4ag #d;a ,s*]+ & ,glatz1 ,new ,york 7#a7 #bjh4e-baj #j4b #d;b ,s*]+ & ,glatz1 ,new ,york 7#b7 #bjh4e-bji4e #j4c #d;c ,s*]+ & ,glatz1 ,new ,york 7#c7 #bjh4e-baj #j4jbe #a ,wm4 ,h4 ,sweet & ,co41 ,columbus #bjd-bjh ,none #b ,wm4 ,h4 ,sweet & ,co41 ,columbus #bji4e-baa4e #j4jd #a ,g]man specim5 f ,s*]+ & ,glatz #baj-bab ,none ,by ref]r+ to ?is table on melt+ po9ts & a% cont5t x w be not$ t ! production ( a bett] grade ( products result$ aft] ! respective firms _h submitt$ samples to ! ,a4 ,m4 ,a4 ,*emical ,laboratory = criticism1 & f a *emical /&po9t1 ! la/ products exam9$ 7 f\nd to be z satisfactory z ! ,g]man-made 8atophan40 ,solubility ( ,c9*oph5 7,ph5ylc9*on9ic ,acid74--,z me?ods ( det]m9+ impurities1 or e/imat+ ! degree ( purity ( ph5ylc9*on9ic acid 7 n describ$ 9 ! ,u4 ,s4 ,ph>macopeia1 x 0 decid$ to try extraction me?ods4#bce ,?is 9 turn l$ to ! "q ( solubilities4 ,! ,u4 ,s4 ,ph>macopeia gives ! solubility ( ph5ylc9*on9ic acid only 9 g5]al t]ms2 h5ce x 0 deem$ advisable to det]m9e its solubilities & describe !m 9 m def9ite t]ms4 ,! sample ( ph5ylc9*on9ic acid employ$ to det]m9e ! solubility 0 obta9$ by repeat$ recry/allization f alcohol ( a comm]cial specim54 ,solubilities 7 det]m9$ 9 wat]2 #ie4j p] c5t4 alcohol2 #dh4e p] c5t4 alcohol2#bcf *lor(orm & e?yl acetate4#bcg ,complete saturation ( ! solv5t 0 atta9$ accord+ to ! ,u4 ,s4 ,p4 ,,ix me?od 7p4 #eii74 ,! ba? 0 ma9ta9$ at a temp]ature ( #be ,c41 ) a range ( #j4b degrees4 ,! solution 0 analyz$ by ! me?od ( ,seidell4#bch ,! data obta9$ = ! solubility ( ph5ylc9*on9ic acid are giv5 9 ,table #e4 ,,table #e4--,,solubility ,,( ,,c9coph5 ,gm4 p] ,hundr$ ,solubility1 ,gm4 ( ,p>ts by ,solv5t ,sat4 ,solution ,weight ,di/ill$ wat] #j4jafj #a 9 #f1baf4j #ie p] c5t4 e?yl alcohol #j4hcdc #a 9 #aai4j ,dilute e?yl alcohol #j4jhge #a 9 #a1adb4f ,*lor(orm1 #j4ajge #a 9 #ibi4g ,e?yl acetate #a4daea #a 9 #gj4f #bce ,attempts 7 made to make salts ( ph5ylc9*on9ic acid ) metals su* z copp]1 m]cury1 b>ium & calcium1 & also ! *loroplat9ic acid or p]iodid addition products4 ,reliable quantitative results c\ld n be obta9$4 #bcf ,?is corresponds to 8dilut$ alcohol1 ,u4 ,s4 ,p40 #bcg ,! e?yl acetate 0 ,m]ck's product 7r$i/ill$71 /at$ to conta9 #ha4f p] c5t4 ( e?yl acetate1 #aj p] c5t4 alcohol & alcohol d]ivatives4 #bch ,seidell1 ,a43 ,bull4 #fg1 ,hyg4 ,lab41 ,u4 ,s4 ,p4 ,h4 ,s41 p4 #aa4 ,! ,abbott ,laboratories1 ,*icago1 h be5 lic5s$ by ! ,f$]al ,trade ,commission to manufacture c9*oph54 ,o!r firms1 h[ev]1 h decid$ to manufacture x )\t ! =mality ( obta9+ a lic5se1 evid5tly consid]+ ! ,g]man-obta9$ pat5t n to be valid4#bci #bci ,v rec5tly ! ,*emical ,f\ndation1 ,inc41 has und]tak5 to grant lic5ses = c9*oph54 ,! ,calco ,*emical ,company has obta9$ "o4 ,,proca9 7,,novoca97 ,proca9 0 introduc$ 9 m$ic9e "u ! propriet>y "n 8novoca910 & be=e ! w> 0 obta9able 9 ?is c\ntry only ?r\gh ! ,f>bw]ke ,hoe*/ ,company1 ! ,am]ican repres5tative ( ! ,g]man e/abli%m5t1 ,f>bw]ke vorm ,mei/] ,lucius ,bru5+1 ,hoe*/ a4 ,m4 ,*emically x is ! mono-hydro*lorid ( p>a-am9o-b5zoyl-die?yl-am9o-e?anol1 hav+ ! /ructural =mula3 ,illu/ration3 ,,nh--7b5z5e r+7,,coo-,,*-,,*--,n7,c,h74,h,cl ,x is prep>$ accord+ to ,u4 ,s4 pat5t ,no4 #habeed 7issu$ to ,alfr$ ,e9horn1 ,muni*1 ,g]many7 by treat+ p>a-nitro-b5zoyl*lorid ) e?yl5e *lorhydr9 & die?ylam9 ) subsequ5t r$uction ( ! nitro gr\ps1 ! result+ product be+ purifi$ by recry/allization4 ,proca9 is employ$ l>gely 9 infiltration ane/hesia4 ,x is less toxic ?an coca91 b its ane/hetic action is n su/a9$4 ,?is drawback is ov]come by ! simultane\s injection ( ep9ephr91 & = ?is reason proca9 is (t5 comp\nd$ ) ep9ephr9 9 tablets1 ?us obviat+ ! necessity ( sep>ate solutions4 ,:5 ! fir/ specim5s ( ! ,am]ican-made product 7 submitt$ ?r\gh ! *annels ( ! ,f$]al ,trade ,commission1 x 0 necess>y to compile a monograph4#bdj ,?is 0 prep>$ f descriptions 9 ! available lit]ature1 mo/ly f te/s describ$ 9 ,new & ,non(ficial ,rem$ies1 #aiah1 & ! ,g]man ,ph>macopeia ,v4 #bdj ,! monograph appe>s 9 ,new & ,non(ficial ,rem$ies1 #aiai4 ,! submitt$ products 7 f\nd satisfactory *emically4 ,! toxicity det]m9ations made by ,dr4 ,r4 ,a4 ,hat*]1 ) ! assi/ance ( ,dr4 ,c>ey ,eggle/on#bda indicat$ t none ( ! specim5s are to be consid]$ dang]\s :5 us$ 9 ord9>y dosage = normal individuals4 ,!re=e ! ,f$]al ,trade ,commission1 on recomm5dation ( ! ,committee on ,syn!tic ,drugs ( ! ,national ,rese>* ,c\ncil 7aid$ by ! ,a4 ,m4 ,a4 ,*emical ,laboratory71 issu$ lic5ses = ! manufacture ( proca9 to ! ,f>bw]ke-,hoe*/ ,company 7:i* lic5se 0 lat] transf]r$ to ! ,h4 ,a4 ,metz ,laboratories71 to ! ,abbott ,laboratories1 to ! ,calco ,*emical ,company & to ! ,rector ,*emical ,company4 #bda ,! report ( ^! & subsequ5t toxicity exp]im5ts on proca9 appe>$ 9 ! report ( ! ,c\ncil on ,ph>macy & ,*emi/ry1 ,j4 ,a4 ,m4 ,a4 #gb3 #acf 7,jan4 #aa7 #aiai4 ,subsequ5tly ! products ( ! lic5s$ firms 7 submitt$ to ! ,c\ncil on ,ph>macy & ,*emi/ry1 :i* 9 turn invok$ ! aid ( ! ,a4 ,m4 ,a4 ,*emical ,laboratory & ! ,cornell ,univ]sity ,ph>macologic ,laboratory4 ,lat] ! ,c\ncil ask$ ! laboratory to exam9e ! m>ket supply4 ,altoge!r1 !re=e1 a numb] ( products 7 exam9$ :i* 7 f\nd to respond satisfactorily to ! te/s outl9$ 7,table #f74 ,,table #f ,date ,melt+ ,a%1 ,br& ,receiv$ ,color ,po9t1 ,c499 ,proca9 7,abbott71 #ab_/ba_/ag ,:ite #aed-aee ,none f ,committee on ,syn!tic ,drugs ,proca9 7,abbott71 #a_/bi_/ah ,:ite #aec4e-aed4e ,none submitt$ to ,c\n- cil ,p4 & ,c4 ,proca9 7,abbott71 #h_/ca_/ah ,:ite #aeb4e-aec4e ,none ,g54 ,pur4 ,(f4 ,u4 ,s4 ,army ,proca9 7,abbott71 #i_/cj_/ah ,slight #aec-aed4e ,none ,g54 ,pur4 ,(f4 br[ni% ,u4 ,s4 ,army1 t9t ,no4 #hiiii ,proca9 7,abbott71 #i_/cj_/ah ,slight #aec-aed4 #j4jje ,g54 ,pur4 ,(f4 br[ni% ,u4 ,s4 ,army1 t9t ,no4 #hiiih ,proca9 7,abbott71 #aj_/h_/ah ,slight #aec-aed ,none ,g54 ,pur4 ,(f4 br[ni% ,u4 ,s4 ,army1 t9t ,no4 #hiiig ,proca9 7,abbott71 #aa_/d_/ah ,slight #aec4e-aed4e ,none ,g54 ,pur4 ,(f4 br[ni% ,u4 ,s4 ,army1 t9t ,no4 #hiiif ,proca9 7,abbott71 #aa_/d_/ah ,slight #aec4e-aed4e ,none ,g54 ,pur4 ,(f4 br[ni% ,u4 ,s4 ,army1 t9t ,no4 #hajiie ,proca9 7,calco71 #b_/g_/ah ,:ite #aec4e-aed4e ,none f ,committee on ,syn!tic ,drugs ,proca9 7,f>bw]ke- #aj_/bd_/ah ,:ite #aec-aed ,none ,hoe*/ ,co471 sub- mitt$ to ,c\ncil ,proca9 7,f>bw]ke- #ab_/aj_/ag ,:ite #aec-aed4e ,none ,hoe*/ ,co471sub- mitt$ to ,c\ncil ,proca9 7,f>bw]ke- #h_/i_/ah ,:ite #aec4e-aed4e ,none ,hoe*/ ,co471 sub- mitt$ to ,c\ncil1 m>ket spec4 8,a #ef0 ,proca9 7,f>bw]ke- #i_/i_/ah ,:ite #aec4e-aed4e ,none ,hoe*/ ,co471 sub- mitt$ to ,c\ncil1 m>ket spec4 8,a #eg0 ,proca9 7,h4 ,a4 ,metz #h_/bc_/ah ,:ite #aec-aed ,none ,lab471 m>ket spec4 8,a #fc0 ,proca9 7,h4 ,a4 ,metz #i_/bc_/ah ,:ite #aec-aed ,none ,lab471 m>ket spec4 8,a #eg0 ,proca9 7,rector71 #ab_/ah_/ag ,:ite #aec-aed4e ,none f ,committee on ,syn!tic ,drugs ,proca9 7,rector71 #e_/b_/ah ,:ite #aeb4e-aec ,none f ,committee on ,syn!tic ,drugs ,proca9 7,rector71 #h_/bj_/ah ,slight #aec-aee ,none m>ket spec br[ni% t9t ,proca9 7,rector71 #h_/bc_/ah ,slight #aec-aee ,none m>ket spec br[ni% t9t ,proca9 7,rector71 #h_/bc_/ah ,slight #aec-aed4e ,none m>ket spec br[ni% t9t ---------------------------------------- --------------------- 99 ,u4 ,s4 ,pat5t #hab1eed--! novoca9 pat5t--decl>es t ! salt melts at #aef ,c4 ,evid5tly bas$ on ?is1 bo? ! ,g]man ,ph>macopeia & pa/ editions ( ,new & ,non(ficial ,rem$ies give ?is melt+ po9t4 ,two specim5s ( ,g]man-made novoca9 obta9$ f our files1 /at$ to be manufactur$ by ,f>bw]ke-,hoe*/ vorm4 ,mei/]1 ,lucius & ,bru5+1 ,hoe*/ a4 ,m41 7 f\nd to melt1 respectively1 betwe5 #aed & #aee ,c4 & betwe5 #aec4e & #aed4e ,c4 :5 ! melt+ po9t 0 det]m9$ accord+ to ! direction ( ! ,u4 ,s4 ,ph>macopeia1 n9? revision4 ,! v>i\s specim5s exam9$ at t "t melt$ betwe5 #aec & #aee ,c41 & x 0 decid$ to p]mit ?is range4 ,an exam9ation ( "s ,am]ican-made proca9-supr>59 tablets 0 also made4 ,! proca9 0 det]m9$ by lib]ation ( ! alkaloid ) ammonia wat]1 extraction ) *lor(orm1 evaporation ( ! *lor(orm1 dissolv+ ! alkaloid 9 "o hundr$? normal sulphuric acid solution & titrat+ excess acid ) "o hundr$? normal sodium hydroxid solution4 ,! ep9ephr9 0 det]m9$ accord+ to ! me?od employ$ by ,seidell1#bdb ) slight modifications4 ,! tablets conta9$ ! claim$ am\nts ( +r$i5ts4 #bdb ,seidell3 ,j4 ,biol4 ,*em4 #ad3 #ai1 #aiac4 ,,! ,,syn!tic ,,drug ,,situation ,be=e ! w>1 ! ,am]ican physician 0 lit]ally bomb>d$ ) new & wond]ful 787 coal-t> syn!tics1 mo/ ( :i* 7 orig9at$ 9 ,g]many4 ,9 fact1 x seem$ t if a by-product 9 ! manufacture ( dyes c\ld n be us$ = a dye p] se1 !n a place might be f\nd = x 9 ! ev] increas+ li/s ( m$icam5ts4 ,by clev] adv]tis+ & propag&a among physicians1 an artificial /imulation = coal-t> drugs 0 creat$ :i* evid5tly yield$ lucrative f9ancial returns4 ,z a result ( ! w>1 x is int]e/+ to obs]ve t ( all ! syn!tic drugs import$ into ?is c\ntry f ,g]many & on :i* ! ,am]ican pat5ts 7 controll$ by ! ,g]mans 7up to ! "t ( our entrance into ! w>71 ! dem& 0 really suffici5t en\gh to w>rant ! comm]cial manufacture ( only f\r ( !m by ,am]ican firms4 ,( c\rse1 a l>g] numb] ( nonpat5t$ drugs1 also import$ f ,g]many1 are n[ be+ made 9 suffici5t quantities 9 ?is c\ntry2 _m ( ! drugs 9 ?is class 7 nev] pat5t$ or are ! ones :i* h surviv$ aft] ! pat5t _h expir$1 su* z acetanilid1 acetph5etid91 & acetylsalicylic acid4 ,9 view ( ! agitation to f\nd an in/itute = coop]ative rese>* z an aid to ! ,am]ican drug indu/ry "u ! auspices ( ! ,am]ican ,*emical ,society1 x w be well = ! m$ical pr(ession to be on its gu>d aga9/ too en?usia/ic propag&a on ! "p ( ^? engag$ 9 ! laudable ent]prise ( promot+ ,am]ican *emical indu/ry4 ,unless x is1 x may be inflict$ 9 ! future1 z 9 ! pa/1 ) a l>ge numb] ( drugs t are ei!r useless1 h>mful or uness5tial modifications ( well-kn[n ph>maceuticals4 ,x w be well also = ! *emi/s--^? engag$ 9 ?is ent]prise--to be sure t ! product is ( !rapeutic value be=e ask+ its use z a m$ic9e4 ,! ,am]ican m$ical pr(ession has le>n$ t relatively few ( ! _m ,g]man syn!tics 7 really valuable or decid$ improvem5ts ov] e/abli%$ drugs4 ,if ,am]ican *emi/s desire to reta9 _! pre/ige ) ! m$ical pr(ession1 !y %\ld e>ne/ly endeavor to see t ! advantages d]iv$ f ! w> & f su* an in/itute z propos$ are n abus$ 9 ! wor?y desire to popul>ize *emi/ry bo? educationally & comm]cially4 ,!y %\ld realize t physicians are 9 no receptive mood = a flood ( syn!tics1 ev5 ?\gh 8,am]ican-made40 ,on ! o!r h&1 ! con/ructive possibilities ( *emi/ry 9 ! s]vice ( m$ic9e %\ld s]ve z a /imulus = ,am]ican rese>*4 ,not)/&+ all ! ph>maceutical %rubb]y :i* ,g]many s5t to u1 /ill x did conta9 "s syn!tics t 7 wor? :ile4 ,z !rapeutics has be5 b5efit$ by ^! organic *emicals1 x is logical to reason by analogy t !re rema9 o!r syn!tics to be discov]$ :i* w occupy places ( equal di/9ction 9 ! mod]n mat]ia m$ica4 ,= example1 vacc9es are ( und\bt$ m]it 9 ! field ( immunology1 b _! action is1 9 ! end1 *emical2 z soon z *emical te*nic is ref9$ by m$ico*emical rese>*1 x is q possible t a def9ite *emical ag5t 7syn!tic7 w sup]s$e ! indef9ite bact]ial vacc9e4 ,obvi\sly ! ,am]ican *emi/ has ! opportunity ( %[+ 8 res\rcefulness 9 aid+ ! public heal? ( ,am]ica & ! _w4 ,9 ?is connection1 a coop]ative in/itute devot$ to purely sci5tific drug rese>*1 & gov]n$ 9 su* a mann] z to inspire confid5ce 9 its humanit>ianism & unbias$ judgm5t1 %\ld s]ve a mo/ comm5dable purpose4 ,! hopes ( ,am]ican m5 ( sci5ce are = a monum5tal rese>* in/itution--coop]ative ) all ! alli$ pr(essions--&1 z ! ,*icago ,*emical ,bullet9 /at$1 8,/ripp$ ( all pr(essional or comm]cial petti%ness & n dom9at$ by any "o gr\p ( sci5ti/s40#bdc #bdc ,propos$ ,in/itute = ,drug ,rese>*1 editorial ,*icago ,*em4 ,bull41 ,april1 #aiai1 p4 #fg4 ,,conclusions ,z = ! results ( ! "w s f>1 !y c be summ$ up 9 two s5t5ces4 #a4 ,am]ican *emi/s are produc+ syn!tic drugs =m]ly controll$ by ,g]many1 & ?us h decl>$ _! indep5d5ce ( ,g]man *emicals4 #b4 ,judg+ f ! evid5ce at h&1 we c feel assur$ t ! quality ( ,am]ican syn!tics w be second to none4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,sept4 #f1 #aiai47 ,,"p ,,iii ,,contributions ,,f ,,! ,,j\rnal3 ,,propriet>y ,,products ,,no/rums ,,9 ,,retrospect ,a ,s]ies ( ,n9e ,articles ,review+ ,wor?less or ,unsci5tific ,propriet>y ,mixtures ,previ\sly ,criticiz$ ,s4 ,q4 ,lapius1 ,m4,d4 ,,=eword4--,x is m ?an twelve ye>s s9ce ! ,c\ncil on ,ph>macy & ,*emi/ry ( ! ,am]ican ,m$ical ,association 0 creat$4 ,s9ce !n !re h be5 b few issues ( ,! ,j\rnal t h n call$ ! att5tion ( ! m$ical pr(ession to ! debas+ influ5ce on sci5tific m$ic9e ( unsci5tific or wor?less propriet>y mixtures adv]tis$ to physicians = _! use 9 prescrib+4 ,! ,c\ncil on ,ph>macy & ,*emi/ry has inve/igat$ & %[n _m ( ^! prep>ations to be fraudul5t 9 "o way or ano!r1 & ^! reports h be5 publi%$ 9 ,! ,j\rnal4 ,9 spite ( ?is1 ^! prep>ations h be5 adv]tis$ cont9u\sly to physicians1 ?r\gh m$ical j\rnals & o!rwise1 & prescrib$ by a l>ge numb] ( physicians4 ,"o reason = ?is is t !re are _m physicians :o h nev] se5 ^! reports--:o 7 n 9 active practice at ! "t1 or :o 7 n read+ ,! ,j\rnal4 ,we probably h among our read]s at ! pres5t "t #ce1jjj or #dj1jjj physicians :o 7 n among ! read]s ( ,! ,j\rnal twelve ye>s ago4 ,x is desirable1 !n1 t we %\ld take up1 9 m or less detail1 sev]al ( ! m widely adv]tis$ products t h be5 ! subjects ( previ\s reports4 ,x has be5 repeat$ly /at$ 9 ,! ,j\rnal t _m ( ! propriet>y mixtures--! s-call$ e?ical propriet>ies adv]tis$ to physicians--7 no bett] & no worse ?an 8pat5t m$ic9es0 adv]tis$ to ! public4 ,e physician :o has ! welf>e ( m$ic9e at he>t %\ld put ^! que/ions squ>ely to himself if he has n already tak5 a firm /& on ?is :ole problem3 ,:at is my attitude t[>d ! "w ( ! ,c\ncil8 ,are its reports wor?y ( acceptance8 ,am ,i uphold+ ! ,c\ncil 9 its ef=ts to place !rapeutics on a rational basis1 n by bl9d fai? alone1 b by an hone/ly critical attitude t[>d x8 ,am ,i foll[+ ! pa? ( indol5ce by tak+ ! advice ( no/rum mak]s )\t any s]i\s ef=t to det]m9e :e!r !y are true or false8 ,9 a ^w1 am ,i really practic+ m$ic9e1 or am ,i an unpaid ag5t & a dupe ( no/rum mak]s8 ,!re are o!r revolutions ?an political4 ,! public c be wrong$ j z c]ta9ly by ! abuse ( its confid5ce 9 cl9icians z by ! usurp]s ( political p[]1 & :5 ! public is ?or\ghly ar\s$ ! heavy h& ( retribution is n likely to be too discrim9at+4 ,t ! s9s ( cl9icians are /&+ out pla9 = any "o :o wi%es to read is becom+ m & m evid5t4 ,!re is b "o %ort & ugly ^w t prop]ly *>act]izes ! physician :o accepts a fee = prescrib+ t ab\t :i* he has no m k ?an has ! "o = :om he prescribes x4 ,are y ) ! no/rum mak]s or ) dec5t m$ic9e8 ,! article bel[ is ! fir/ ( a s]ies writt5 = ,! ,j\rnal by "o :o is ?or\ghly conv]sant ) ! "w ( ! ,c\ncil on ,ph>macy & ,*emi/ry & c speak au?oritatively on que/ions deal+ ) ! action ( drugs & ! treatm5t ( diseases4 ,we believe t ^! articles w prove ( int]e/ & pr(it & t !y w help physicians to answ] ! que/ions j prop\nd$4 ,,article ,i ,bell-,ans 7,pa-,pay-,ans ,bell7,h ,h ,see also 88884sic ,bell-ans1 = ye>s adv]tis$ only 9 m$ical j\rnals "u ! "n 8,pa-pay-ans 7,bell710 is n[ adv]tis$ 9 newspap]s z a rem$y t 8,absolutely ,removes ,indige/ion40 ,z x is /ill be+ adv]tis$ to physicians1 we propose to analyze ! claims made = x ) z mu* c>e z w\ld be ex]cis$ 9 ! discussion ( ! newe/ discov]y 9 m$ic9e1 because we believe t x is desirable to %[ ! tr5d ( exploitation ( a c]ta9 type ( prep>ation 9 ! m$ical press4 ,9 ! ,new ,york ,m$ical ,j\rnal ! foll[+ adv]tisem5t rec5tly appe>$ on ! front cov]3 ,illu/ration3 ---------------------------------------- --------------------- ,acute ,indige/ion ,ye/]day a great soldi] & today ! head ( a big tru/ succumb$ to an attack ( ,acute ,indige/ion1 & e day we he> f "s physician ( "s case he has sav$ ) ,,bell-,,ans by giv+ ,,six 7#f7 tablets dissolv$ 9 a glass ( hot wat] & repeat+ if necess>y4 ,c any doctor :o reads ?is fail to provide himself ) ! free supply ( ,,bell-,,ans :i* we w gladly s5d = 8 em]g5cy case8 ,bell ,co4 7,inc47 ,mfg4 ,*emi/s ,orangeburg ,new ,york ,u ,s ,a ---------------------------------------- --------------------- ,typical ( ,bell-ans adv]tisem5ts z appe>+ 9 m$ical j\rnals4 ,a rec5tly pur*as$ package ( ,bell-ans conta9$ a circul> 9 :i* x 0 /at$ t ,bell-ans removes flatul5ce1 v]tigo1 weakness & o!r symptoms ( indige/ion quickly & pleasantly2 t x aids ! dige/ion ( food & t5ds to re/ore ! dige/ive tract to a normal condition2 t x relieves vomit+ 9 pregnancy1 alcoholism1 seasickness & *ol]a morbus1 besides be+ pleasant1 h>mless & effective = colic1 s\r /oma*1 fev]i%ness1 & wakefulness ( infants & *ildr54 ,! circul> conta9$ p>agraphs purport+ to be tak5 f v>i\s m$ical j\rnals1 includ+ ! ,new ,york ,m$ical ,j\rnal1 ,wiscons9 ,m$ical ,record]1 ! ,lancet ,cl9ic1 ,int]national ,j\rnal ( ,surg]y1 & ,massa*usetts ,m$ical ,j\rnal4 ,no exact ref]5ces 7 giv5 to p]mit v]ification or to det]m9e :e!r or n ! quotations 7 f 8read+ notices0 7adv]tisem5ts7 or f ! sci5tific "p ( ! j\rnals 9 "q4 ,to quote "o ( ! /atem5ts giv53 8,! results f ! use ( ,bell-ans 7,pa-,pay-ans ,bell7 9 ! treatm5t ( indige/ion are s prompt & s g5]ally good--& ! evid5ce ( ?is fact is accumulat+ s rapidly & f su* reliable s\rces--t we v5ture to sugge/ to our read]s :o h n tri$ ?is rem$y t !y prescribe "o orig9al seal$ package ( ,bell-ans 7,pa-pay-ans ,bell7 & t !y c>efully note ! results f its use4 8,we sugge/ an orig9al seal$ package because ! prep>ation is widely & badly imitat$1 & unless su* a package is specifi$ an imitation ( little value may be sub/itut$ & ! exp]im5t be ?us r5d]$ useless40 ,x is possible t ,bell-ans has be5 imitat$1 b x is n true t x is widely imitat$1 = no su* imitation has ev] be5 call$ to our att5tion1 & we /rongly suspect t ! ma9 reason = desir+ t an orig9al package be disp5s$ is t ! pati5t may see = himself ! "n ,,bell-,,ans pla9ly bl[n 9 ! glass4 ,! circul> 9 "q /ates t !re is no d]angem5t ( ! dige/ive organs on :i* ! prop] dose ( ,bell-ans w n act quickly & pleasantly6 ,^! are samples ( ! claims made = ,bell-ans4 ,let u inquire into ! nature ( ! conditions = :i* ! prep>ation is recomm5d$ & ! treatm5t advis$ by well kn[n cl9icians4 ,! subject ( indige/ion is discuss$ by ,rob]t ,hut*ison & ,rob]t ,saundby "u ! g5]al title ( dyspepsia 9 ! 8,index ( ,treatm5t by ,v>i\s ,writ]s10 ,edition #f1 #aiab1 pp4 #bfj-bfe4 ,hut*ison says3 8,9 ! fir/ place x mu/ be rememb]$ t 9 _m pati5ts :o compla9 ( #8indige/ion' ! seat ( ! tr\ble is n 9 ! /oma* at all40 ,illu/ration3 ---------------------------------------- ------------------------- ,a ,philadelphia ,doctor writes3 8,y\r ,,bell-,,ans = +e/ion d j :at y claim & m too4 ,i1 p]sonally1 _h a bad case ( inte/9al indige/ion ) ga/ric v]tigo4 ,i _h tak5 almo/ ev]y?+ & got no relief1 until ,i comm5c$ to take ,,bell-,,ans--f\r to six tablets 9 a l>ge glassful ( hot wat] aft] ea* meal4 ,y h my p]mission to use ?is /atem5t1 ) my "n & address if y wi%4 ,i prescribe ,,bell-,,ans con/antly0 ,,bell-,,ans ,,= ,,indige/ion #be;c package at e drug /ore 9 ! ,u4 ,s4 ---------------------------------------- ------------------------- ,newspap] adv]tisem5t ( ,bell-ans1 capitaliz+ ! /atem5ts ( physicians4 ,! g5]al pr9ciples to be obs]v$ 9 ! treatm5t ( functional dyspepsia1 z giv5 by ,hut*ison1 are3 7#a7 to remove ! cause2 7#b7 to adapt ! diet to ! impair$ functional p[] ( ! /oma*2 7#c7 to adm9i/] su* drugs z are calculat$ to /imulate or correct ! p>ticul> function or functions :i* happ5 to be impair$1 or disord]$4 ,prop] diet1 prop] ma/ication ( food1 hygi5e ( ! m\?1 & con/ipation are enum]at$ z des]v+ att5tion4 ,c>eful att5tion to secur+ a prop] diet is ess5tial4 ,! *oice ( drugs dep5ds1 ( c\rse1 on ! conditions t give rise to indige/ion1 & he calls att5tion to ! necessity ( avoid+ all r\t9e treatm5t & compil+ "o's prescription ) an eye to ! special disord] or disord]s ( function1 :e!r secretory1 motor or s5sory1 believ$ to be pres5t4 ,hut*ison gives ! foll[+ typical prescriptions to illu/rate ! use ( drugs 9 ! diff]5t disord]s ( function3 ,,= ,,hyp]secretion 7,,hyp]*lorhydria1 ,,acid ,,dyspepsia1 ,,etc47 ,sodium bromid #aj gra9s ,bismu? subc>bonate #ae gra9s ,*lor(orm wat] #a_/b ounce ,?is mixture to be tak5 be=e meals4 ,sodium bic>bonate4 ,bismu? subc>bonate4 ,heavy magnesium c>bonate1 ( ea* equal p>ts4 ,a small teaspoonful ( ! p[d] to be tak5 mix$ ) a little wat] or milk ab\t two h\rs aft] meals4 ,,= ,,defici5t ,,secretion 7,,hypo*ylia1 ,,a*ylia1 ,,ga/ritis1 ,,etc47 ,sodium bic>bonate #aj gra9s ,t9cture ( nux vomica #aj m9ims ,_s ( *lor(orm #h m9ims ,comp\nd infusion ( g5tian #a_/b ounce ,?is mixture to be tak5 be=e meals4 ,dilute hydro*loric acid & glyc]91 ( ea* #ae m9ims ) en\gh wat] to make half an ounce1 to be tak5 ab\t tw5ty m9utes aft] meals4 ,,= ,,defective ,,motility 7,,atonic ,,dyspepsia1 ,,ga/roptosis1 ,,etc47 ,hut*ison recomm5ds ! use ( #aj m9ims ( t9cture ( nux vomica 9 an aromatic vehicle1 su* z infusion ( quassia & comp\nd t9cture ( c>damom2 b ano!r aromatic bitt]1 su* z ! comp\nd t9cture ( g5tian1 w s]ve q z well1 ( c\rse4 ,?is is to be tak5 be=e ea* meal1 & = ! flatul5ce t (t5 accompanies ?is tr\ble he gives m5?ol1 aromatic _s ( ammonia & _s ( *lor(orm1 z may be ne$$4 ,,= ,,acid ,,dyspepsia ,rob]t ,saundby recomm5ds ! foll[+ to be us$ be=e ea* meal = ! relief ( acid dyspepsia3 sodium bic>bonate1 bismu? subc>bonate1 magnesium c>bonate1 ( ea* #aj gra9s2 mucilage ( tragacan? #ae m9ims1 & en\gh pepp]m9t wat] to make an ounce4 ,^! are only a few ( ! conditions t are discuss$ by ,hut*ison & ,saundby1 b !y s]ve to %[ t ! treatm5t ( indige/ion by a s+le prescription or comb9ation is :olly irrational4 ,bell-ans1 bo? "u its pres5t "n & "u its old] "n1 8,pa-pay-ans 7,bell710 has always be5 alleg$ by its manufactur]s to conta9 papa9 or to be a prep>ation ( ! dige/ive juice f ! fruit ( ,c>ica papaya 7papaw7 ) o!r sub/ances4 ,v>i\s *emi/s h attempt$ to f9d papa9 pres5t & to det]m9e ! dige/ive p[] ( ! tablets1 b )\t success4 ,= ?is reason ,! ,j\rnal sugge/$ t ! *ange ( "n f 8,pa-pay-ans 7,bell70 to 8,bell-ans0 0 probably n made entirely = euphoni\s reasons1 z alleg$1 especially :5 "o consid]s t ! "n ( a no/rum is its mo/ valuable asset4 ,x is mu* m likely t z analyses indicat$ !re 0 n & probably nev] _h be5 any papa9 pres5t 9 ! product1 ! "n 0 *ang$ = fe> t "s day ! mislead+ t]m 8,pa-pay-ans0 might br+ ! prep>ation 9 conflict ) ! f$]al ,food & ,drugs ,act4 ,pa-pay-ans 7,bell7 0 exam9$ = ! ,c\ncil on ,ph>macy & ,*emi/ry 9 #aiji & ! tablets 7 f\nd to consi/ ( *>coal1 sodium bic>bonate1 g+]1 sac*>9 & oil ( gaul!ria4 ,no dige/ive f]m5t c\ld be detect$ 9 ! tablets4 ,sodium bic>bonate is antacid & s]ves to dissolve mucus2 g+]1 if 9 suffici5t am\nt1 causes ! expulsion ( flatus1 & *>coal1 :ile an absorb5t 9 ! dry /ate1 is probably useless = any !rapeutic purpose :atev] aft] x becomes saturat$ ) ga/ric juice4 ,bell-ans1 !n1 has all ( ! virtues1 :i* are few1 & all ( ! limitations1 :i* are _m1 ( a tablet ( sodium bic>bonate & g+]4 ,its value 9 ! treatm5t ( acute indige/ion w\ld be limit$ to ! value ( a tablet ( su* a composition4 ,x is absurd to suppose t x c\ld h ! slighte/ value 9 ! f> m s]i\s conditions att5d$ ) inte/9al indige/ion1 ) ! toxemia & auto9toxication to :i* !y give rise4 ,bell-ans is n[ adv]tis$ directly to ! public--b x is no less valuable on t acc\nt4 ,true1 x is a 8pat5t m$ic9e0 9 ! commonly accept$ s5se ( ! t]m1 b x is no m a 8pat5t m$ic9e0 today ?an x 0 fifte5 ye>s ago :5 x rea*$ ! public1 n ?r\gh ! direct m$ium ( ! newspap]s b ! m indirect r\te ( ! m$ical j\rnals & undiscrim9at+ physicians4 ,x is true t1 9 view ( ! s]i\s nature ( _m conditions :i* are loosely spok5 ( by ! public z 8indige/ion10 its pres5t me?od ( exploitation is likely to make x j t mu* m dang]\s because ( ! l>g] publicity t w be giv54 ,! po9t to be borne 9 m9d is t ,bell-ans is n[ 9 fact :at x has always be5 9 ess5ce1 a 8pat5t m$ic9e40 ,illu/ration3 - - - - - - - ,,bus9ess ,,notice ,,bell-,,ans ,absolutely ,removes ,indige/ion4 ,"o package proves x4 #be;c at all druggi/s4 - - - - - - - ,typical ( ,bell-ans adv]tisem5ts z appe>+ 9 newspap]s4 ,aga9 we ask ! "q3 ,h[ d y wi% to be classifi$1 ,doctor--among ^? :o foll[ bl9dly ! lead ( a firm ( no/rum mak]s1 or among ! intellig5t memb]s ( ! pr(ession :o /udy _! cases c>efully & prescribe intellig5tly8 ,! manufactur]s ( ,bell-ans claim t #ajj1jjj ,am]ican physicians n[ prescribe ,bell-ans1 & t #fjj1jjj1jjj ( ! tablets are sold annually4 ,if ?is is ev5 approximately true x is a s]i\s reflection on ! m$ical pr(ession1 = ! ,c\ncil exam9$ ,bell-ans & report$ its f9d+s ne>ly eight ye>s ago 7,j4 ,a4 ,m4 ,a4 #ec3efi ,aug4 #ad #aiji71 & ! /atem5ts made 9 t report are z incontrov]tible today z !y 7 !n4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #bd1 #aiag47 ,,article ,,ii ,anas>c9 & ,an$em9 8,anas>c90 & 8,an$em90 are ! tw9 no/rums ( c>diac pseudo!rapy4 ,!y are dubb$ 8tw9 no/rums0 n s mu* because ( any simil>ity 9 _! =mulas1 t be+ a m9or consid]ation 9 ! av]age no/rum1 b because ( ! close simil>ity 9 _! me?ods ( exploitation1 ! !rapeutic claims made = !m1 & ! "t & place ( _! bir?4 ,x may be rememb]$ t !y bo? claim ,w9*e/]1 ,t5n41 z _! bir?place1 & !y appe>$ on ! m>ket at ab\t ! same "t2 fur!rmore1 a comp>ison ( ! claims =m]ly made = bo? ( !m indicat$ t "o m9d conceiv$ ! ma9 idea t lies back ( _! exploitation4 ,:ile ,anas>c9 is especially dealt ) 9 ?is article1 mu* ( ! discussion applies ) equal =ce to ,an$em94 ,a ,,lu% ,,field ,,= ,,no/rums ,c>diac disease1 ) its resultant r5al involvem5t1 is frequ5tly enc\nt]$2 & runn+1 z x does1 a *ronic c\rse1 x (f]s an almo/ ideal field ( exploitation = ! typical no/rum v5d]4 ,by a typical no/rum v5d] we mean "o ^: k ( 8 product is f> bel[ t ( 8 appreciation ( a c]ta9 elem5t ( human "*4 ,on ?is elem5t re/s ! :ole secret ( ! no/rum v5d]'s success4 ,x is v>i\sly t]m$ cr$ulity1 gullibility & *ildlike simplicity1 b x is t :i* (t5 causes ev5 ! mo/ consci5ti\s cl9ician to turn aside f ! use ( ! be/ kn[n & mo/ dep5dable drugs at 8 comm&1 9 ! face ( disappo9tm5t & failure1 & employ "s vaunt$ mixture :i*1 9 8 san] mom5ts1 he scorns to use4 ,an$em9 is said to consi/ ( a 8,sci5tific ,comb9ation ( ?ree ( ! m rec5tly inve/igat$ memb]s ( ! ,digitalis ,s]ies1 ) ,sambucus02 t is1 ( apocynum1 /rophan?us & squill ) eld]4 ,x is difficult to "k j :at idea ! /atem5t t x is a 8sci5tific comb9ation0 ( ^! drugs is int5d$ to convey1 = x is unsci5tific to mix ?ree drugs ( ?is gr\p = use 9 fix$ proportion 9 a wide range ( conditions1 if inde$1 !re is ev] any indication = _! use4 ,! great disadvantages ( /rophan?us & apocynum p]ta9 to ! extreme unc]ta9ty ( _! absorption f ! ga/ro-inte/9al tract4 ,/rophan?us is occasionally absorb$ promptly1 sometimes s sl[ly t ! !rapeutic effects are n induc$ until an am\nt equal to sev]al times t :i* w\ld prove fatal if all ( x 7 absorb$ into ! circulation has be5 adm9i/]$1 &1 un=tunately1 "o _c control ! absorption :i* may cont9ue until a fatal effect is induc$4 ,?is is true to an ev5 great] degree ( apocynum1 & x 0 due to ! recognition ( ?is fact t apocynum 0 n admitt$ to ! ,u4 ,s4 ,ph>macopeia ,,ix1 ! committee on dosage hav+ agre$ t no safe & effective dose c\ld be giv54 ,,! ,,c\ncil',s ,,previ\s ,,f9d+s ,9 #aijg ! ,c\ncil on ,ph>macy & ,*emi/ry exam9$ ! lit]ature us$ 9 ! exploitation ( ,anas>c9 & ,an$em9 & publi%$ its report4 ,anas>c9 tablets1 x 0 po9t$ out1 7 said to conta9 ! active pr9ciples ( ,oxyd5dron arboreum 7s\r wood71 ,sambucus canad5sis 7eld]7 & ,urg9ea scilla 7squill71 & ! foll[+ claims 7 made = ! no/rum3 8,does :at dropsy m$icam5ts h hi!rto fail$ to accompli%40 8,sup]ior to digitalis1 /rophan?us1 scop>ius1 squills1 acetate ( pota% & ! hydragogue ca?>tics all put toge!r40 8,! only kn[n relief & p]man5t cure ( dropsies40 8,unrival$ he>t tonic40 8,! mo/ p[]ful ag5t kn[n40 8,safe 9 adm9i/ration40 8,non-toxic z ord9>ily adm9i/]$40 8,w nauseate "s p]sons10 b 8! reaction f ! tempor>y depression is prompt40 8,9 ,bright's disease1 bo? ! int]/itial & p>5*ymat\s =ms ( nephritis1 acute or *ronic1 no rem$y 444 to equal x 9 efficacy40 8,)\t increas+ ! debility ( ! pati5t or int]f]+ ) nutrition by produc+ loss ( appetite 4440 8,?is treatm5t is to be cont9u$ )\t cessation until all symptoms ( dropsy h disappe>$40 ,a comp>ison ( ! e>li] claims ) ^? n[ be+ made 7see adv]tisem5t reproduc$ f ! ,new ,york ,m$ical ,j\rnal7 illu/rates "o ( ! results ( ! "w ( ! ,c\ncil4 ,today ! no/rum exploit] avoids ! crud] =ms ( obvi\s mis/atem5t1 b cont9ues to make1 by inf]5ce1 claims t are equally mislead+4 ,x w be obs]v$ 9 ?is case t a m cauti\s p5 word$ ! lat] adv]tisem5t1 b !re is /ill evid5t ! int5t to conv9ce ! read] t ,anas>c9 is sup]ior to ! (ficial drugs 9 ! treatm5t ( c>diovascul> diseases4 ,! facts are t ,anas>c9 is at be/ a dang]\s rem$y 9 ! h&s ( ! av]age cl9ician 9 ! treatm5t ( su* conditions1 & its use is at all times to be condemn$4 ,no compet5t inve/igator has ev] inve/igat$ ! ph>macology ( s\r wood 7,oxyd5dron arboreum71 & x appe>s to h no !rapeutic value o!r ?an t due to a slight acidul\sness4 ,eld] 7,sambucus canad5sis7 conta9s a trace ( a volatile oil z its mo/ important con/itu5t1 accord+ to ! ,briti% ,ph>maceutical ,codex ( #aiaa 7p4 #ijh71 b x is difficult to expla9 :y a trace ( volatile oil %\ld be consid]$ important4 ,eld] may be dismiss$ )\t fur!r consid]ation 9 connection ) ,anas>c9 tablets4 ,,! ,,ph>macology ,,( ,,squill ,?is leaves only squill among ! con/itu5ts ( ,anas>c9 = consid]ation4 ,sollmann 7,manual ( ,ph>macology1 #aiag1 p4 #dji7 9 discuss+ ! advantages claim$ = squill ov] o!r drugs ( ! digitalis gr\p1 says3 8,dixon1 #aijf1 po9ts out t any sup]iority is outweigh$ by its disadvantages3 unc]ta9 absorption2 /rong ga/ro-inte/9al irritation40 ,squill 0 =m]ly us$ z an expectorant & diuretic1 ! activity hav+ be5 attribut$ to two amorph\s glucosids1 scillipicr9 & scillitox91 b ,ew9s1 #aiaa1 f\nd ^! to be impure mixtures4 ,a lat] inve/igator claim$ to h isolat$ two glucosidal ag5ts f squill1 b simil> claims h (t5 be5 made only to be disprov$ lat]1 & we "k ( no confirmation ( ! claims reg>d+ ! isolation ( any pure pr9ciples f squill hav+ any true typical digitalis action4 ,! /atem5t quot$ f ,sollmann is accept$ by practically all ph>macologi/s1 & we may say ) c]ta9ty t squill is decid$ly inf]ior to digitalis 9 ! treatm5t ( c>diovascul>1 & c>dior5al diseases1 & c]ta9ly no active pr9ciples ( squill 7 kn[n to ! sci5tific _w at a "t t ! rem>kable claims 7 fir/ made = ,anas>c9 by an obscure ph>maci/ ( ,w9*e/]1 ,t5n4 ,inde$1 if ,anas>c9 7 all t x 0 claim$ to be1 its discov]y w\ld h made ,w9*e/] z fam\s z a c]ta9 ,wiscons9 city 0 said to h be5 made by a popul> bev]age4 ,x has be5 abundantly demon/rat$1 & x is n[ almo/ univ]sally accept$ among well in=m$ ph>macologi/s & cl9icians1 t all digitalis pr9ciples ex]t ! same k9d ( action on ! he>t aft] !y ent] ! circulation 9 effective doses1 ?\gh !y diff] to an extraord9>y degree 9 ! int5sity ( _! action & 9 _! undesir$ sideactions1 su* z nausea & vomit+4 ,:5 ! use ( ,anas>c9 7squill7 is foll[$ by imm$iate improvem5t aft] digitalis has fail$1 x m]ely %[s t ! dosage ( digitalis 0 insuffici5t or t x 0 discont9u$ & ! squill mixture 0 sub/itut$ be=e ! full !rapeutic effects ( ! digitalis develop$4 ,,:5 ,,! ,,digitalis ,,gr\p ,,is ,,contra9dicat$ ,if ! adm9i/ration ( a suffici5t dose ( digitalis is n foll[$ by improvem5t 9 ! circulation1 x %[s t ! he>t is incapable ( respond+ to su* treatm5t & ! fur!r use ( any ( ! drugs ( ?is gr\p is di/9ctly contra9dicat$4 ,?is is confirm$ by ! exp]i5ce ( ne>ly e compet5t obs]v] ( digitalis !rapy1 & num]\s fatalities h result$ f ! failure to appreciate ?is fact & fur!r adm9i/] "s o!r memb] ( ! gr\p1 su* z /rophan?us or squill4 ,x is n[ well kn[n t ! c>diac effects ( toxic doses ( squill1 & o!r memb]s ( ! gr\p1 resemble closely ^? ( c>diac disease1 & x is (t5 impossible to det]m9e :e!r ! behavior ( ! he>t 9 a giv5 case is attributable to insuffici5t dosage1 to excessive dosage1 or to ! progress ( ! c>diac disease itself4 ,if ?is occurs :5 "o uses ! be/ kn[n memb]s ( ! gr\p1 x is c]ta9 t x occurs ev5 m frequ5tly :5 o!rs t are less und]/ood are employ$4 ,9 ! light ( ?is k ( ! dang]s att5d+ ! incauti\s use ( any memb] ( ! digitalis gr\p1 & m especially ! use ( impure pr9ciples1 su* z are commonly obta9$ f squill1 x is impossible to condemn suffici5tly ! recomm5dation t ! use ( ,anas>c9 %\ld be cont9u$ )\t cessation until all symptoms ( dropsy h disappe>$4 ,digitalis bodies are n suit$ = ! treatm5t ( all c>diac di/urbances1 & x is1 ( c\rse1 self-evid5t t a "t mu/ come 9 ! treatm5t ( *ronic c>diac disease :5 ! he>t is incapable ( respond+ to any =m ( treatm5t ) improvem5t4 ,b1 un=tunately1 x nev] loses its response to toxic doses1 & to pu% ! adm9i/ration ( any drug or mixture conta9+ any drug ( ! entire digitalis gr\p--& especially ^?1 l squill1 9 :i* ! side actions are mo/ prom95t--beyond ! po9t ( tol]ance is to c\rt c]ta9 disa/]4 ,,! ,,treatm5t ,,( ,,c>diac ,,dropsy ,:ile x is q c]ta9 t _m lives h be5 sacrific$ to ! failure to und]/& ?is phase ( c>diac !rapy1 x is equally c]ta9 t _m lives h be5 sacrific$ because ( insuffici5t dosage1 & "o c /e] a safe c\rse betwe5 ^! dang]s only by us+ ! be/ kn[n prep>ation available2 & 9 ! pres5t /ate ( our k x is indisputable t digitalis & ! t9cture ( digitalis are be/ suit$ = ! treatm5t ( c>diac disease except 9 ^? few cases 9 :i* intramuscul> or intrav5\s adm9i/ration mu/ be employ$ tempor>ily = imm$iate effect4 ,illu/ration ,! secret ( prescrib+ successfully = ! relief ( dropsy 9 c>diac disease consi/s 9 und]/&+ ! effects ( digitalis on ! he>t1 9 adm9i/]+ x until ^! effects indicate t ! desir$ object has be5 obta9$1 & /opp+1 or int]rupt+1 ! adm9i/ration at t po9t until ! effects beg9 to we> (f4 ,cumulation1 s call$1 is a positive advantage 9 su* cases4 ,x m]ely means t ! desir$ !rapeutic effects once induc$ p]si/ = a "t1 & t fur!r m$ication is unnecess>y dur+ su* p]si/5ce ( action4 ,eggle/on has rec5tly %[n 7,ar*4 ,int4 ,m$4 #af3a ,july #aiae2 ab/r41 ,j4 ,a4 ,m4 ,a4 #dd3dei ,july #ca #aiae7 t ! full !rapeutic effects ( digitalis c be induc$ 9 suitable cases )9 a few h\rs ev5 ) oral adm9i/ration4 ,we are n aw>e ( a s+le publication 9 :i* a c>eful1 detail$ cl9ical /udy ( ,anas>c9 has be5 report$4 ,! claims made = ,anas>c91 pa/ & pres5t1 indicate ei!r a delib]ate purpose to mislead or crass ignorance ( ! rudim5ts ( ph>macology & !rapeutics4 ,! exploit]s ( ! no/rum claim t ?\s&s ( physicians h f\nd ,anas>c9 tablets ( unsurpass$ rem$ial value 9 ! treatm5t ( disord]s ( ! circulatory sy/em & ( ascitic conditions4#bdd ,x mu/ be admitt$ t too _m physicians h prescrib$ ,anas>c91 o!rwise ! manufactur]s w\ld n h cont9u$ to sp5d ?\s&s ( doll>s 9 adv]tis+ x 9 m$ical j\rnals dur+ a p]iod ( m ?an t5 ye>s4 #bdd ,=m] e/imates ( ! numb] ( physicians :o prescrib$ ,anas>c9 appe> to h be5 too high1 possibly bas$ on ! ratio obta9+ 9 ,w9*e/]1 ,t5n4 ,inquiry at five fairly busy drug /ores 9 a l>ge ea/]n city %[$ t 9 no in/ance 0 ! ph>maci/ ev5 acqua9t$ ) ! "n4 ,"o pret5d$ to be1 & manife/$ pity = ! inquir]'s ignorance 9 suppos+ t x c\ld be import$ dur+ ! w>6 ,he 0 obvi\sly m]ely less hone/ ?an ! o!rs1 :o frankly admitt$ !y _h nev] he>d ( x4 ,doctor1 ?is article is meant to be a c&id discussion ) y1 :e!r y use ,anas>c9 or n1 because e cl9ician is vitally int]e/$ 9 ! cu/oms t obta9 9 ! practice ( m$ic9e1 & we wi% to put a hypo!tic "q to y4 ,answ] x1 at lea/ to y\rself1 9 exactly ! _s 9 :i* x is put4 ,suppose t y prescribe ,anas>c9 = a pati5t :o is critically ill ) c>diac disease4 ,he dies4 ,are y will+ to tell ! relatives frankly j :at y us$ & ! nature ( ! evid5ce on :i* y bas$ y\r *oice ( ?is no/rum8 ,let ! supposition be c>ri$ fur!r & say t ! case 0 hopeless1 & agree t digitalis & all o!r drugs w\ld h be5 equally ineffective4 ,grant+ all ?is1 w\ld y\r explanation satisfy8 ,w\ld y 9 all c&or d>e to (f] su* an explanation8 ,try x z a hypo!tic case be=e y are =c$ to apply x4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,dec4 #h1 #aiag47 ,,article ,,iii ,pepto-,mangan ,x w\ld be int]e/+1 & ev5 in/ructive1 to "k h[ _m educat$ physicians1 if any1 are n[ prescrib+ ,pepto-,mangan 7,gude73 int]e/+ z indicat+ ! numb] :o h neglect$ to avail !mselves ( ! "w ( ! ,c\ncil on ,ph>macy & ,*emi/ry1 especially ! e>li] "w2 in/ructive 9 t x w\ld %[ h[ _m are /ill prescrib+ by ! rule ( ?umb1 & :o are tak+ _! !rapeutic in/ructions f purely comm]cial s\rces in/ead ( /riv+ to le>n h[ to *oose ^? drugs t are mo/ effective 9 ! treatm5t ( disease4 ,x has be5 po9t$ out _m times 9 ! pages ( ,! ,j\rnal t _m no/rums are adv]tis$ fir/ to physicians1 & t aft] physicians h s]v$ z ! unpaid ag5ts ( ! manufactur]s 9 introduc+ ! prep>ations1 _! exploitation is !n commonly cont9u$ by means ( adv]tisem5ts 9 ! public press4 ,?is plan has be5 foll[$ successfully 9 s _m cases t we h n[ come to look on x z ! regul> c\rse4 ,x is 9 keep+ ) ?is rule t we f9d ,pepto-,mangan n[ adv]tis$ 9 ! public press1 ! physicians hav+ s]v$ ! manufactur]'s purpose4 ,,disc>d$ ,,!ories ,,( ,,iron ,,m$ication ,x w be recall$ t _m ye>s ago ! !ory 0 held t hydrog5 sulphid 7sulphuret$ hydrog57 int]f]$ ) ! absorption ( ! iron ( ! food1 & t ! adm9i/ration ( m$ic9al iron prev5t$ ?is int]f]5ce by neutraliz+ ! hydrog5 sulphid 7sulphuret$ hydrog574 ,x 0 only a %ort /ep to argue t manganese might replace ! m$ic9al iron 9 comb9+ ) ! hydrog5 sulphid1 p]mitt+ ! food iron to be absorb$1 & x 0 held t only food iron c\ld be utiliz$ 9 ! =mation ( hemoglob94 ,x is h>dly necess>y to rem9d ! read] t ?is !ory re/s on num]\s fallacies4 ,!re is no hydrog5 sulphid wor? m5tion+ 9 ! small inte/9e :]e iron is absorb$2 food iron _c be utiliz$ directly 9 ! =mation ( hemoglob9 b mu/ be brok5 into simple =ms = absorption2 &1 fur!r1 inorganic iron1 su* z f]r\s c>bonate1 s]ves ! purpose admirably :5 iron is indicat$4 ,) ! acceptance ( ^! well e/abli%$ facts1 all possible excuse = ! !rapeutic employm5t ( ,pepto-,mangan 9 place ( iron vani%$2 b z pla9 & simple z ?is fact is1 ! unnecess>y & exp5sive ,pepto-,mangan cont9ues to be prescrib$ by physicians :o w n take ! slight tr\ble to inve/igate ! claims = ?is no/rum4 ,,false ,,& ,,mislead+ ,,claims ,!re is n m]ely a diff]5ce ( op9ion betwe5 ! exploit]s & ! ,c\ncil1 b !re has be5 also actual misrepres5tation 9 ! exploitation ( ?is no/rum to physicians4 ,?is has be5 %[n on m ?an "o occasion4 ,ab\t twelve ye>s ago1 ! ,m4 ,j4 ,breit5ba* ,company1 ! proprietors ( ,pepto-,mangan1 claim$ t ! report ( ! commission t _h be5 appo9t$ = ! inve/igation ( anemia 9 ,porto ,rico 8w\ld alone suffice to e/abli% ,pepto-,mangan at once z ! =emo/ hemat9ic kn[n40 ,exam9ation ( ! report %[$ t ! commission made no su* claims2 on ! contr>y ! commission prote/$ aga9/ ?is misrepres5tation 7,j4 ,a4 ,m4 ,a4 #de3ajii ,oct4 #g #aije74 ,illu/ration3 ,f ! ,new ,york ,m$ical ,j\rnal4 ,undaunt$ by ?is exposure ( _! me?ods1 ! ,breit5ba* ,company lat] s5t out a /atem5t ( results purport+ to h be5 obta9$ by "o ,mateo ,m4 ,gill51 9 ! treatm5t ( infantile anemia on ,r&all's ,isl& 9 ,new ,york ,city4 ,at ! in/ance ( ,! ,j\rnal ! hospital records 9 ^! cases 7 exam9$1 & x 0 f\nd t ! pret5d$ report 0 little m ?an a tissue ( falsehood 7,j4 ,a4 ,m4 ,a4 #dh3aaig ,april #f #aijg74 ,ab\t two ye>s ago ! ,c\ncil report$ t :ile ! /atem5ts j ref]r$ to 7 no long] made1 !y _h nev] be5 def9itely admitt$ by ! ,breit5ba* ,company to be errone\s1 & t ,pepto-,mangan 0 !n be+ exploit$ to ! public indirectly4 7,c\ncil ,reports1 #aiad1 p4 #aba47 ,we reproduce an adv]tisem5t t has be5 appe>+ weekly 9 ! ,new ,york ,m$ical ,j\rnal = sev]al mon?s4 ,"o c only suppose t ?is adv]tisem5t 0 int5d$ to mislead physicians1 & x w\ld be an insult to ! intellig5ce ( ! av]age read] to attempt any detail$ discussion ( x1 b en\gh has be5 said to %[ h[ mislead+ ! /atem5ts are4 ,"o %\ld note p>ticul>ly ! advice--old z ! no/rum bus9ess itself--conta9$ 9 ! adv]tisem5t1 to prescribe an orig9al bottle4 ,! reason = su* advice is simple4 ,exp]i5ce has %[n t :5 orig9al bottles are disp5s$ pati5ts soon le>n to buy ! no/rum )\t consult+ ! physician1 = !y %rewdly suspect t he kn[s no m ab\t ! prep>ation ?an !y1 & t he gets 8 in=mation f precisely ! same s\rces t are available to !m4 ,!y are obvi\sly "r4 ,9 tru?1 ! physician :o prescribes ,pepto-,mangan z a hemat9ic %[s ignorance ( ! mo/ rudim5t>y facts ( iron !rapy1 & ! intellig5t pati5t soon p]ceives 8 limitations4 ,illu/ration3 ,a newspap] adv]tisem5t ( ,pepto-,mangan4 ,,! ,,problem ,,( ,,iron ,,!rapy ,! inve/igation ( ! problems ( iron !rapy & its utilization 9 ! =mation ( hemoglob9 =ms "o ( ! mo/ brilliant *apt]s 9 ph>macologic rese>*1 & !re is no bett] e/abli%$ fact 9 !rapeutics ?an t any organic or inorganic prep>ation ( iron t does n irritate ! /oma* may be employ$ effectively :5 ! adm9i/ration ( iron is indicat$4 8,useful ,drugs0 conta9s a li/ ( iron prep>ations t are suitable = all conditions :i* call = iron1 & ! cl9ician may re/ assur$ t he w nev] h occasion to g outside t li/ to prescribe any sub/itute4 ,z a matt] ( fact1 x seems probable t ! v numb] ( available iron prep>ations has s]v$ to cause confusion1 ?us af=d+ an opportunity = ! no/rum mak] to introduce 8 sup]flu\s comp\nds4 ,x may be difficult at times to select ! prep>ation ( iron be/ suit$ to ! individual pati5t2 & x is ?is difficulty t has l$ ! cl9ician to li/5 to ! s$uctive claims made = ! v>i\s pret5d$ sub/itutes = iron4 ,"o %\ld approa* ! "q ( *oos+ ! prop] =m ( iron = !rapeutic use ) ! recognition ( ! fact t !re is no su* ?+ z a sub/itute = iron 9 ! =mation ( hemoglob91 t !re are no ideal =ms ( iron o!r ?an ^? f\nd 9 ! food/uffs4 ,fur!r1 ! cl9ician _c avoid ! disadvantages inh]5t 9 all =ms ( iron t he c prescribe1 & he mu/ !re=e seek t :i* seems be/ suit$ = ! individual pati5t4 ,bunge e/imat$ ! am\nts ( iron pres5t 9 v>i\s foods2 & a table bas$ on ?is1 & o!r data1 is giv5 9 8,ph>macology ( ,useful ,drugs0 7publi%$ by ! ,am]ican ,m$ical ,association74 ,ord9>y foods 9 an ample diet conta9 en\gh iron to supply ! normal daily loss1 :i* am\nts to only a few milligrams1 b _m p]sons :o h poor appetites take an insuffici5t am\nt ( iron 9 _! food & become anemic4 ,9 su* cases ! additional iron requir$ c be suppli$ be/ by add+ sp9a*1 eggs1 apples1 or o!r iron-ri* food to ! diet>y4 ,,"s ,,iron ,,comb9ations ,william ,hunt] discusses ! subject ( anemia & its treatm5t at consid]able l5g? 9 ! 8,index ( ,treatm5t10 ,ed4 #f1 pp4 #ag-cg1 & gives _m prescriptions conta9+ iron = use "u diff]5t conditions2 & :ile x is unnecess>y to reproduce all ( ^! "h1 a few may be giv5 9 ord] to sugge/ suitable me?ods ( prescrib+ iron :5 x _c be giv5 9 suffici5t am\nts 9 ! food4 ,9 *lorosis ,hunt] advises t t =m ( iron :i* exp]i5ce has %[n to be lea/ di/urb+ to ! pati5t's /oma* %\ld be us$1 & he sugge/s sep>ate /oma*ic mixtures to be us$ simultane\sly1 n mix$ ) ! iron itself4 ,:5 con/ipation exi/s--& ?is is a v common accompanim5t ( *lorosis--he gives ! foll[+ ap]i5t iron comb9ation3 ,gm4 or c4c4 ,f]r\s sulphate #be gr4 iv ,magnesium sulphate #d i ,aromatic sulphuric acid #e vii ,t9cture ( g+] #g x ,comp\nd infusion ( g5tian 7,b4 ,p47 q4 s41 ad #cj i ,?is1 con/itut+ a s+le dose1 is to be tak5 twice daily--at #aa a4 m4 & #f p4 m4 ,a little comp\nd t9cture ( g5tian & wat] may be us$ 9 place ( ! comp\nd infusion ( ! ,briti% ,ph>macopeia4 ,he modifies ?is some:at z occasion dem&s by us+ sodium sulphate & add+ sodium bic>bonate 7:i* conv]ts ! sulphate ( iron into f]r\s c>bonate7 & adds #aj m9ims ( _s ( *lor(orm to act z a /oma*ic4 ,hunt] also sugge/s ! use ( pills ( aloes & iron 9 place ( ! mixture describ$ above1 & :5 con/ipation has be5 correct$1 ! aloes may be omitt$ & ! pill ( f]r\s c>bonate alone may be us$ = ! iron4 ,hunt]'s comm5t reg>d+ ?is pill is1 8v satisfactory40 ,! same =m ( iron is available 9 ! comp\nd iron mixture1 =m]ly (ficial1 :i* ,hunt] says is exce$+ly good4 ,9 ?is c\ntry ! comp\nd solution ( iron & ammonium acetate1 ,ba%am's mixture1 s call$1 has long enjoy$ a wide reputation z caus+ v little di/urbance ( ! /oma*1 & ! homely t9cture ( f]ric *lorid is probably useful 9 a l>ge majority ( cases 9 :i* ! /oma* is n especially irritable4 ,we may say ) assurance t "o ( ! =ms sugge/$ "h w suffice = practically e case 9 :i* x is necess>y to re9=ce ! am\nt ( iron available 9 ! food by "s ph>maceutical prep>ation4 ,if ^! d n satisfy y\r requirem5ts1 consult a really compet5t ph>maci/ & enli/ 8 aid 9 devis+ a mixture especially suit$ to y\r individual pati5t4--7,f ! ,j\rnal ,a4 ,m4 ,a41 ,dec4 #bi1 #aiag47 ,,article ,,iv ,cact9a ,pillets ,?is prep>ation may be consid]$ briefly 9 view ( ! rec5t discussion 9 ?is s]ies ( articles ( ! ph>macology ( ! digitalis gr\p & ! pr9ciples ( treatm5t 9 c>diovascul> disease4 ,! manufactur]s ma9ta9 t cact9a is :olly unlike digitalis1 & t is ! tru?1 z we %all %[2 b s9ce !y claim t x is useful 9 c]ta9 conditions ( ! he>t 9 :i* digitalis is commonly employ$ by well in=m$ cl9icians1 x is necess>y to consid] its c>diac actions--or its lack ( !m6 ,x is difficult to det]m9e j :at action cact9a is suppos$ to ex]t on ! he>t4 ,= example1 "o adv]tisem5t conta9s ! foll[+3 8,cact9a ,pillets4 ,a g5tle c>diac tonic t supports & su/a9s ! he>t ?r\gh its capacity to improve c>diac nutrition40 ,j h[ ! c>diac nutrition is to be improv$ )\t an improv$ coron>y circulation is n expla9$4 ,x w\ld be int]e/+ to "k 9 :at o!r way ?is is to be accompli%$1 & h[ an improv$ coron>y circulation c be induc$ )\t act+ on ! he>t or vessels4 ,b t is :at digitalis does1 & y %\ld rememb] t cact9a is s v diff]5t f digitalis6 ,!n aga93 8,cact9a ,pillets4 ,a rem$y t /eadies & /r5g!ns ! he>t by imp>t+ tone to ! he>t muscle40 ,t is a pretty direct /atem5t1 b digitalis imp>ts tone2 & we mu/ n =get t 8cact9a0 is :olly unlike digitalis1 & we are told t 8cact9a0 is3 8,invaluable 9 all functional c>diac disord]s su* z ta*yc>dia1 palpitation1 arrhy?mia1 & :5ev] ! he>t's action ne$s regulat+ or support40 ,if ^! are m]ely functional disord]s ( ! he>t1 x is highly desirable to "k :at are ! symptoms ( really s]i\s c>diac disease6 ,s9ce ! manufactur]s give u no in=mation conc]n+ ! mode ( action ( 8cact9a0 we w turn to ! lit]ature ( dis9t]e/$ obs]v]s4 ,if "o attempts to discov] ! orig9 ( 8cact9a10 he w probably meet ) disappo9tm5t1 = v>i\s bibliographies fail to m5tion ! "n ( ,sultan1 :o is said to h isolat$ 8cact9a0 f ,cactus gr&iflorus4 ,x seems t ,sultan work$ ) ,cactus1 or "s o!r plant1 :5 a /ud5t ( ph>macy1 & x is to be rememb]$ t ,cact9a ,pillets are manufactur$ by ! ,sultan ,drug ,company4 ,x is d\btful :e!r ,sultan actually work$ ) g5u9e ,cactus gr&iflorus2 &1 9 fact1 !re is good reason = ?9k+ t he did n1 = all subsequ5t work]s :o h tak5 pa9s to secure g5u9e ,cactus gr&iflorus h fail$ to detect ! pres5ce ( any active pr9ciple1 except possible traces t are ( no !rapeutic importance :atev]4 ,,:at ,,! ,,c\ncil ,,f\nd ,! ,c\ncil on ,ph>macy & ,*emi/ry exam9$ ! lit]ature relat+ to cactus & c]ta9 propriet>y prep>ations1 includ+ ,cact9a ,pillets1 alleg$ to be made f cactus1 & has report$ ! results ( its inve/igation 7,j4 ,a4 ,m4 ,a4 #ed3hhh ,m>* #ab #aiaj7 & we w quote f t report4 8,! !rapeutic value ( ?is plant has be5 v>i\sly e/imat$ by diff]5t obs]v]s4 ,exp]im5tal evid5ce z to its action is scanty & no complete *emical exam9ation has ev] be5 made4 8,reputable m5 h te/ifi$ t "s ( ! plants ( ! cactus family conta9 v active pr9ciples1 b s f> exp]im5ts seem to prove t ,cactus gr&iflorus has nei!r ! action ( digitalis nor t ( /ry*n94 ,! pr9cipal contributions1 cl9ical & exp]im5tal1 = & aga9/ ! drug are set out bel[40 ,illu/ration3 ,typical adv]tisem5ts ( 8,cact9a ,pillets0 f ! ,m$ical ,record & ,new ,york ,m$ical ,j\rnal1 respectively4 ,! report !n proce$s to analyze ! "w ( ,o4 ,h4 ,my]s1 ,r4 ,a4 ,hat*]1 ,bo9et & ,boy-,teissi]1 ,sayre1 ,gordon ,%>p1 ,s4 ,a4 ,mat!ws1 ,p4 ,w4 ,williams1 ,aulde & ,ell+wood1 & comes to conclusions t are set =? z foll[s1 9 brief3 #a4 ,x is unc]ta9 :at "p ( ! plant conta9s ! active pr9ciple1 if any su* pr9ciple exi/s4 #b4 ,"p ( ! exp]im5tal & cl9ical "w has be5 publi%$ "u propriet>y auspices4 #c4 ,! value ( cl9ical evid5ce :5 unsupport$ by animal exp]im5tation is mu* dim9i%$ by ! t5d5cy ( en?usia/ic & untra9$ obs]v]s to attribute to ! drug giv5 ! effect really due to g5]al rem$ial measures1 psy*ic sugge/ion & s =?4 ,9 o!r words1 ! lit]ature does n af=d a report ( a s+le piece ( c>eful pa9/ak+ "w ! results ( :i* l5d support to ! claims made = ,cact9a ,pillets z /at$ above1 = x is obvi\s t if ,cactus gr&iflorus conta9s no active pr9ciple1 no active pr9ciple c be extract$ f x4 ,"s "t aft] ! report ( ! ,c\ncil 0 publi%$1 ,hat*] & ,bailey secur$ g5u9e ,cactus gr&iflorus directly f a compet5t botani/1 ,dr4 ,c4 ,a4 ,purpus1 ( ,v]a ,cruz1 ,mexico1 & /udi$ x exp]im5tally4 ,!y report$ 7,j4 ,a4 ,m4 ,a4 #ef3bf ,jan4 #g #aiaa7 9 "p z foll[s3 8,we h be5 unable to obta9 any evid5ce t ! true ,mexican ,cactus gr&iflorus possesses any ph>macologic action :atev]2 b1 on ! contr>y1 x appe>s to be a s+ul>ly in]t sub/ance :5 adm9i/]$ ei!r by ! m\? or by ! ve940 ,:5 colossal doses ( ,cactus gr&iflorus are giv5 by ! ve91 !y sometimes--b n always--appe> to ex]t an extremely feeble action on ! he>t2 b ?is action is s slight t its nature c\ld n be det]m9$4 ,ev5 ! mo/ colossal doses ( ,cactus gr&iflorus adm9i/]$ by ! m\? to cats1 dogs & frogs ex]t no p]ceptible effect4 ,sollmann ?us satirizes ! absurd claims made by ! exploit]s ( propriet>y =ms ( cactus3 8,%\ld ! he>t be too sl[1 cactus quick5s x2 if ! he>t is too fa/1 cactus sl[s x2 %\ld ! he>t be too weak1 cactus /r5g!ns x2 if ! he>t is too /rong1 cactus weak5s x2 does ! he>t wobble1 cactus /eadies x2 if ! he>t is normal1 cactus does n m$dle ) x0 7,j4 ,a4 ,m4 ,a4 #ea3eb ,july #d #aijh74 ,w physicians cont9ue to accept ! /atem5ts ( an int]e/$ no/rum v5d]--:o submits n a %r$ ( evid5ce to support 8 claims1 b :o has a f9ancial int]e/ 9 conv9c+ !m--ev5 :5 8 /atem5ts are diametrically oppos$ to all ! evid5ce t ! ,c\ncil on ,ph>macy & ,*emi/ry has be5 able to secure8--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #ai1 #aiah47 ,,article ,v ,ammonol & ,ph5alg9 ,at ! "t t syn!tic *emical drugs 7 com+ into fame & :5 e manufactur] :o laun*$ a new heada*e mixture claim$ to h a*iev$ ano!r triumph 9 syn!tic *emi/ry1 ,ammonol & ,ph5alg9 7 born4 ,( c\rse1 ^! tw9s ( analgesic pseudo!rapy 7 claim$ to be syn!tics & 7 duly *ri/5$ ) 8=mulas40 ,!y 7 among ! fir/ ( ! no/rums exam9$ = ! ,c\ncil on ,ph>macy & ,*emi/ry1 & ! false claims made = !m 7 expos$4 ,! analyses made = ! ,c\ncil %[$ t ,ammonol & ,ph5alg9 7 simple mixtures1 hav+ ! foll[+ composition3 ,,acetanilid ,,sodium ,,bic>bonate ,,ammonium ,,c>bonate ,,ammonol #ej #be #bj ,,ph5alg9 #eg #bj #aj ,! reports ( ! ,c\ncil on1 & num]\s ref]5ces to1 ^! two no/rums may be f\nd 9 ,! ,j\rnal ( v>i\s dates4#bde ,! reports w prove int]e/+ to ^? :o are n famili> )1 or h =gott51 ! me?ods ( no/rum exploit]s at ! "t ! ,c\ncil 0 =m$4 ,foll[+ ! ,c\ncil's exposure ( ! false claims made by ! manufactur]s ( ,ph5alg91 ! ,m$ical ,record publi%$ an adv]tisem5t ( t no/rum 9 :i* an attempt 0 made to discr$it ! ,c\ncil's report4 ,! editor ( ! ,m$ical ,record 0 reque/$ by ! ,c\ncil to publi% ! facts 9 ! case b he refus$ to d s4 #bde ,j4 ,a4 ,m4 ,a4 #dd3 #agia 7,june #c7 #aije2 ibid4 #dd3 #aiig 7,june #bd7 #aije2 ibid4 #de3 #ice 7,sept4 #bc7 #aije2 ibid4 #df3 #acd 7,jan4 #ac7 #aijf2 ibid4 #df3 #bij 7,jan4 #bg7 #aijf2 ibid4 #eh3 #bhj 7,jan4 #bg7 #aiab4 ,long aft] ! dea? ( ,dr4 ,cyrus ,edson1 ! claim 0 made t ,ph5alg9 0 made "u 8 direction & t x 0 8 8discov]y40 ,z a matt] ( fact1 ,dr4 ,edson _h favor$ ! use ( ,ammonol at "o "t1 & :5 ! ,c\ncil expos$ ! false claims !n be+ made = ,ph5alg91 ,! ,j\rnal *>g$ t a fraud 0 be+ p]petrat$ on ! m$ical pr(ession4 ,despite ! exposure ( ! me?ods us$ 9 exploit+ ,ammonol & ,ph5alg91 "o f9ds j z gl>+ly false /atem5ts made 9 ! adv]tisem5ts ( ,ph5alg9 today z 7 made 9 its unsavory pa/4 ,?is w\ld seem to indicate ei!r t physicians h %ort memories or t !y are /rangely indiff]5t to ! welf>e ( _! pati5ts1 to _! own reputations & to ! good "n ( m$ic9e4 ,! ,new ,york ,m$ical ,j\rnal ( ,dec4 #bb1 #aiag1 conta9$ an adv]tisem5t ( ,ph5alg9--x has be5 runn+ = mon?s--f :i* ! foll[+ is quot$3 8,= ! relief ( ,,pa9 ! #8logical supplant] ( opium & o!r habit-=m+ drugs' is ,,ph5alg94 ,no matt] h[ sev]e or :]e locat$ pa9 is promptly & satisfactorily controll$ by ?is effective anodyne--& )\t di/urb+ ! dige/ion1 suppress+ ! secretions1 caus+ con/ipation or induc+ a drug habit4 8,?is is :y ,ph5alg9 has sup]s$$ opium & its d]ivatives = reliev+ ,,heada*es1 ,,rheumatism1 ,,g\t1 ,,la ,,grippe1 ,,lumbago1 ,,neuralgia1 ,,disord]s ,,( ,,! ,,female1 ,,dysm5orrhea1 ,,& ,,pa9ful ,,conditions ,,g5]ally4 ,to ?\s&s ( physicians ,ph5alg9 #8is ! "o dep5dable analgesic--! logical supplant] ( opium4'0 ,if we are to suppose t ! composition ( ,ph5alg9 is today ess5tially ! same z :5 x 0 exam9$1 ! claims j quot$ are obvi\sly false =1 ( c\rse1 su* a mixture mu/ h ! prop]ties ( acetanilid ) all ( its drawbacks & limitations4 ,we may contra/ ! /atem5ts made 9 ! adv]tisem5t j quot$ ) ^? made 9 ,bullet9 #abf ( ! ,bureau ( ,*emi/ry ( ! ,u4 ,s4 ,dep>tm5t ( ,agriculture4 ,?is bullet9 on 8,! ,h>mful ,effects ( ,acetanilid1 ,antipyr9 & ,ph5acet90 summ>izes ! replies receiv$ f #djj physicians to :om a que/ionnaire _h be5 s5t4 ,! in=mation ?us ga9$ 0 tabulat$ & ! figures t foll[ are f ^! tables4 ,!re 7 report$ no few] ?an #fad cases ( poison+ by acetanilid ) #af dea?s & #aab cases ( its habitual use4 ,! l>g] numb] ( cases ( poison+ foll[$ ! adm9i/ration ( ! drug1 by physicians1 9 doses l>g] ?an ^? n[ reg>d$ z fairly safe4 ,?is l>ge numb] report$ by only #djj physicians indicat$ an excessively l>ge numb] 9 ! :ole c\ntry4 ,s9ce ! que/ionnaire 0 s5t to ne>ly a ?\s& physicians1 ( :om ab\t #ejj fail$ to reply1 x may be assum$ t _h x be5 s5t to ! entire #acj1jjj physicians 9 ! c\ntry1 at lea/ #ge1jjj cases ( poison+ w\ld h be5 report$4 ,prior to ! passage ( ! f$]al ,food & ,drugs ,act 7! 8,pure ,food ,law07 _m no/rum mak]s _h decl>$ t _! prep>ations conta9$ no acetanilid4 ,:5 t law w5t into effect1 "s ( ^! manufactur]s triumphantly po9t$ to ! fact t !y 7 /ill able to make ! same claim )\t conflict+ ) ! requirem5ts ( ! law4 ,?is 0 accompli%$ 9 fact by *ang+ ! =mula & sub/itut+ acetph5etid9 7ph5acet97 = ! acetanilid4 ,:ile acetph5etid9 is some:at less toxic ?an acetanilid1 bulk = bulk1 ! toxicity & !rapeutic activity ( ! two drugs are ne>ly proportional4 ,! claim made by _m propriet>y m$ic9e manufactur]s t !y are 8/rictly e?ical0 because !y adv]tise only to physicians is m]e v]bal cam\flage4 ,!re may be no m c]ta9 way ( insur+ ! cont9u$ use ( a no/rum by ! public ?an to h x prescrib$ by physicians2 & none "k ?is bett] ?an ! mak]s ( no/rums4 ,a propriet>y individuality is obta9$ by giv+ "s special =m to ! tablets & package or a special color+ to ! capsules 78,specify #8,ph5alg9 ,p9k ,top ,capsules'07 s z to indicate ! id5tity ( ! products 9 su* a way t ! pati5t may 9 ! future procure !m )\t ! advice or w>n+ ( ! physician4 ,:5 a propriet>y prep>ation ) ! "n or initials /amp$ on x or atta*$ to x is prescrib$1 ! pati5t imm$iately is aw>e ( ! fact1 & 8 respect = ! physician's intellig5ce & wisdom is naturally less5$4 ,! physician %\ld nev] place su* dang]\s drugs z acetanilid & acetph5etid91 or ready made mixtures ( !m1 9 ! h&s ( ! pati5t 9 su* a way t !y c be employ$ )\t 8 sup]vision or control4 ,he %\ld nev] prescribe m ?an is ne$$ at ! "t & %\ld n =m ! habit ( us+ fix$ doses or comb9ations ( drugs )\t a special ref]5ce to ! p>ticul> ne$s ( ! individual4 ,c]ta9 =ms ( heada*e yield m readily to a mixture ( caffe9 & acetanilid or caffe9 & acetph5etid9 ?an to ei!r acetanilid or acetph5etid9 alone4 ,:5 ! physician wi%es to prescribe su* a mixture he may comb9e #a gra9 ( caffe9 or #b gra9s ( citrat$ caffe9 ) #c gra9s ( acetanilid or #d gra9s ( acetph5etid9 9 a p[d] or capsule4 ,"u sup]vision su* a dose may be repeat$ at int]vals ( f two to f\r h\rs if necess>y to control pa94 ,x is necess>y to rememb]1 h[ev]1 t :5 small doses fail to give relief1 increase 9 ! dose is useless4 ,?is fact is especially important1 & disreg>d or ignorance ( x has be5 responsible = _m cases ( poison+4 ,fur!r1 x %\ld be rememb]$ t :ile x 0 taught = _m ye>s t ! admixture ( caffe9 ) acetanilid less5$ ! effect ( ! latt] drug on ! he>t1 ,hale has %[n t ?is is n ! case & su* mixtures mu/ be us$ ) special caution4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,feb4 #b1 #aiah47 ,,article ,,vi ,fell[s' ,syrup1 & ,o!r ,prep>ations ( ! ,hypophosphites ,we hope t x is cle> to ^? :o h read ! sev]al articles ( ?is s]ies t _! purpose is to pres5t evid5ce t w enable ! read] to =m a correct e/imate ( ! lit]ature employ$ 9 ! exploitation ( v>i\s no/rums4 ,! di/9ction betwe5 m]e ass]tion--h[ev] plausible1 & f h[ev] em95t an au?ority--& evid5ce %\ld aga9 be emphasiz$4 ,satisfactory evid5ce re/s on c>eful obs]vation by ^? :o are capable ( accurately det]m9+ to :at ext5t any *anges t may be obs]v$ are due to ! !rapeutic ag5t employ$ & n m]e accompanim5ts ( su* treatm5t4 ,:5 ! ,c\ncil on ,ph>macy & ,*emi/ry 0 organiz$ 9 #aije1 ! great] "p ( ! lit]ature ( ! no/rums 0 s palpably mislead+1 ! /atem5ts (t5 s ludicr\sly false1 t x 0 only necess>y to call att5tion to ?is fact to h ^? claims collapse4 ,z a result ( ! ,c\ncil's "w1 ! exploit]s ( wor?less no/rums h develop$ a great] degree ( %rewdness 9 avoid+ ! easily explod$ falsehoods4 ,?is has made x increas+ly difficult to po9t out ! exact /atem5ts on :i* _m ( ! false claims n[ re/1 ev5 ?\gh ! exploitation z a :ole is z inh]5tly di%one/ z be=e4 ,if a no/rum is wor?less1 any exploitation mu/ be false & mislead+ 9 effect1 ev5 ?\gh n "o s+le false direct /atem5t is made4 ,a platitude may be giv5 an appe>ance ( importance if utt]$ 9 an impressive mann]1 & x may be employ$ to sugge/ f> m ?an x categorically affirms4 ,^! two facts are appreciat$ by _m no/rum exploit]s & we f9d t !y h adopt$ ! impressive mann] to secure att5tion1 & ! platitude to sugge/ f> m ?an !y c\ld def5d 9 direct /atem5t4 ,?us we h ! 8lie ) circum/ance40 ,,fell[s' ,,syrup ,a full page adv]tisem5t1 :i* has be5 appe>+ regul>ly = ab\t a ye> & :i* mu/ repres5t a good deal ( money1 is us$ to give an appe>ance ( importance to a few words :i*1 if pr9t$ 9 ord9>y type1 w\ld ei!r pass :olly unnotic$ or w\ld lead "o to assume t some?+ ess5tial to ! full mean+ _h be5 omitt$4 ,! /atem5t1 9 full reads3 8,fell[s' ,syrup diff]s f o!r prep>ations ( ! hypophosphites4 ,lead+ cl9icians 9 all p>ts ( ! _w h long recogniz$ ?is important fact4 ,h y8 ,to insure results1 prescribe ! g5u9e ,syr4 ,hypophos4 ,comp4 ,fell[s'4 ,reject *eap & ineffici5t sub/itutes4 ,reject prep>ations #8j z good4'0 ,! only direct /atem5t conta9$ 9 ! adv]tisem5t is to ! effect t _m cl9icians h obs]v$ t ,fell[s' syrup & o!r prep>ations ( ! hypophosphites are n alike4 ,9 tru?1 ,fell[s' is n l ! bett] prep>ations ( ?is type1 s9ce aft] /&+ x conta9s a muddy look+ deposit t any ph>maceutical tyro w\ld be a%am$ (4 ,te*nically1 !n1 ! /atem5t is true1 b x is h>dly cr$ible t ! manufactur] is pay+ = an entire page 9 a m$ical j\rnal to make ?is /atem5t )\t any attempt to sugge/ some?+ else4 ,! adv]tis+ pages ( six m$ical j\rnals 7 exam9$ 9 ! ord] 9 :i* !y *anc$ to come to h&4 ,9 five ( ^!1 ! entire adv]tisem5t ( ,fell[s' syrup 0 9 ! words j quot$2 n a s+le ^w m4 ,9 "o !re 0 ! fur!r /atem5t3 8,n a new-born prodigy or an untri$ exp]im5t1 b a rem$y ^: usefulness has be5 fully demon/rat$ dur+ half a c5tury ( cl9ical application40 ,^! adv]tisem5ts %[ t ! exploit]s ( ,fell[s' ,syrup are sp5d+ a great deal ( money to induce physicians to prescribe ! prep>ation1 & x is equally evid5t t !y wi% to convey ! impression t ! prep>ation has "s !rapeutic value4 ,s9ce we f9d no?+ directly false1 9 ! fir/ m5tion$ adv]tisem5t at lea/1 we mu/ take ! evid5t int5t = consid]ation & det]m9e :at !rapeutic value1 if any1 ?is prep>ation has1 & :e!r x is advisable = physicians to employ x 9 any case4 ,! prep>ation1 accord+ to ! /atem5t j cit$1 has be5 9 use = fifty ye>s4 ,z ! exploit] ( any prep>ation cites ! mo/ conv9c+ evid5ce 9 8 possession 9 support ( 8 views1 ?is claim may be assum$ to be ! /ronge/ available1 & if ?is evid5ce fails we mu/ reject ! cont5tion z n prov$4 ,"h we face a dilemma1 = exam9ation ( ! lit]ature us$ 9 ! exploitation ( ,fell[s' ,syrup fails to disclose any evid5ce ( ! k9d t we h describ$ z satisfactory2 & we are1 !re=e1 =c$ to conclude t none has ev] be5 f\nd4 ,by ?is x is n to be impli$ t no reputable physician has ev] report$ favorably conc]n+ ! !rapeutic effects ( ?is prep>ation4 ,x is q possible t an ext5sive lit]ature ( t sort might be f\nd if "o exam9$ ! old] m$ical j\rnals4 ,b ! day has pass$ :5 e improvem5t t foll[s ! adm9i/ration ( a prep>ation is bl9dly attribut$ to ! drug 9 "q4 ,cl9ical rese>* today is f> m exact+4 ,we w assume t ! read] :o has inve/igat$ ! "q ) an op5 m9d w h come to ! decision t ! cont5tion t ,fell[s' syrup is ( especial !rapeutic value is n prov$4 ,we might re/ ) t assumption & ask ! cl9ician :e!r he is prep>$ to use a no/rum t has be5 be=e ! m$ical pr(ession = half a c5tury )\t any satisfactory evid5ce hav+ be5 ga9$ t x possesses !rapeutic value4 ,we might ask him :e!r he w\ld be will+ to tell 8 pati5ts t he 0 prescrib+ su* a no/rum = !m 9 ! face ( ! abs5ce ( any su* evid5ce ( its value4 ,,! ,,in]tness ,,( ,,! ,,hypophosphites ,b we pref] to g ev5 fur!r & %[ him t n only is !re an entire abs5ce ( any evid5ce ( its !rapeutic value s f> z we h be5 able to le>n1 b 9 addition !re is an abundance ( evid5ce t ! hypophosphites are devoid ( any su* !rapeutic effect z !y 7 =m]ly reput$ to h1 & t1 9 fact1 !y are1 s f> z any effect bas$ on _! phosphorus cont5t is conc]n$1 s+ul>ly in]t4 ,:ile we h ?us f> tak5 ! ,fell[s' prep>ation z ! subject ( ! discussion1 we may take a broad] view & exam9e ! subject ( ! hypophosphites 9 g5]al1 & ! sub/itutes conta9+ phosphorus t h be5 introduc$ f "t to "t4 ,x h>dly ne$s to be said t if ! hypophosphites are )\t !rapeutic value1 x is impossible to give !m value by comb9+ !m 9 a muddy-look+1 ill-made prep>ation su* z ,fell[s' ,syrup4 ,su* evid5ce 0 submitt$ to ! m$ical pr(ession 9 a report ( ! ,c\ncil on ,ph>macy & ,*emi/ry 7,j4 ,a4 ,m4 ,a4 #fg3gfj ,sept4 #b #aiaf72 & we w\ld /rongly advise any "o :o is dispos$ to act on ! sugge/ion conta9$ 9 ! adv]tisem5ts ( ,fell[s'1 & o!r hypophosphite prep>ations1 to read t report 9 full & to ?9k ! matt] ov] be=e prescrib+ "o ( ^! no/rums4 ,quot+ briefly f ! report 9 "q3 8,al?\gh ! ov]:elm+ weight ( evid5ce 0 aga9/ ! probability t ! hypophosphite prep>ations are ( value z !rapeutic ag5ts1 ! ,c\ncil ?\ght x well to inve/igate ! subject4 ,dr4 ,w4 ,mc,kim ,m>riott ( ,baltimore 0 !re=e reque/$ to review ! evid5ce = & aga9/ ! !rapeutic usefulness ( ! hypophosphites & to conduct su* exp]im5ts z seem$ necess>y40 ,! ,c\ncil 0 n cont5t to re/ on ! m]e abs5ce ( evid5ce = ! value ( ^! prep>ations or any "o ( !m1 b s\ght to obta9 evid5ce t w\ld fulfil ! conditions m5tion$ above1 & 9 pursuance ( ?is plan x secur$ ! coop]ation ( a tra9$ inve/igator1 "o :o w\ld "w "u ! be/ ( conditions = le>n+ ! tru?4 ,! results ( ,dr4 ,m>riott's inve/igation 7 publi%$ 9 ,! ,j\rnal1 ,feb4 #ab1 #aiaf1 p4 #dhf1 & %\ld be read by ev]yone :o has any int]e/ 9 ! problem4 ,le/ "s ( our read]s may fail to ref] to ! orig9al ( ,m>riott's pap]1 we w quote briefly f x3 8,none ( ! subjects ( ! exp]im5t exp]i5c$ any effect :atsoev] f ! adm9i/ration ( ! drug 444 ,almo/ all ( ! +e/$ hypophosphite is elim9at$ un*ang$4444 8,^! exp]im5ts 7,=bes7 demon/rate conclusively t ! hypophosphites possess no specific value z a s\rce ( phosphorus = ! body4444 ,x is d\btful if !re are any conditions 9 :i* ! body suff]s f lack ( phosphorus4 ,ev5 %\ld su* conditions exi/1 phosphorus1 9 ! =m t x occurs 9 ! ord9>y foods1 or z phosphates1 is m effici5t 9 supply+ ! deficit ?an hypophosphites t mu/ be oxidiz$ be=e utilization & :i* are only ab\t #ae p] c5t4 oxidiz$ if at all4 ,= example1 half a glass ( milk conta9s m available phosphorus ?an ?ree l>ge doses ( hypophosphites ( #ae gra9s ea*1 z great a dosage z is usually giv54 8,:at !n1 is ! !rapeutic value ( hypophosphites8 ,!re is no reliable evid5ce t !y ex]t a physiologic effect2 x has n be5 demon/rat$ t !y influ5ce any pa?ologic process2 !y are n #8foods4' ,if !y are ( any use1 t use has nev] be5 discov]$40 ,! case seems to /& ab\t l ?is3 ,a no/rum mak] sp5ds ?\s&s ( doll>s to tell physicians t 8 cl\dy prep>ation is n l o!r prep>ations1 & physicians are expect$ to accept t z conv9c+ evid5ce t !y %\ld prescribe & _! pati5ts1 p]=ce1 take x4 ,?is too1 9 spite ( ! evid5ce ga9$ by c>eful sci5tific inve/igators t ! hypophosphites 9 fairly l>ge doses conta9 less available phosphorus ?an half a glass ( milk1 & t !re is no evid5ce available t !y ex]t any !rapeutic effects at all4 ,%\ld we take ! mean+less /atem5t ( a no/rum mak]1 :o does n submit evid5ce ( any !rapeutic value ( 8 prep>ation--unless "o c call c]ta9 c>eless habits ( prescrib+ evid5ce--& assume ! responsibility ( prescrib+ a no/rum t accord+ to all sci5tific evid5ce available is useless1 & ( no m effect ?an a few teaspoonfuls ( milk1 s f> z its hypophosphite cont5t is conc]n$8 ,x may be argu$ t x possesses "s value because ( its bitt] nature4 ,we w n d5y t x is bitt]2 s is /ry*n91 s is qu991 s are scores ( simple drugs1 b :at physician w\ld c>e to admit to 8 pati5ts t he did n "k h[ to prescribe a simple bitt]1 su* z ne>ly e layman c select = himself1 )\t rec\rse to a prep>ation su* z ,fell[s' ,syrup8 ,we h felt t x is n :olly satisfactory to disc\rage ! use ( a giv5 no/rum )\t mak+ an ef=t to assi/ ! physician 9 *oos+ wisely 9 ! treatm5t ( ! condition = :i* ! no/rum is claim$ to be useful4 ,9 ! pres5t in/ance1 h[ev]1 we fe> t w\ld prove a task beyond our p[]s1 = ! hypophosphites h be5 us$ 9 su* a v>iety ( conditions t ! discussion w\ld h to include ne>ly ! :ole mat]ia m$ica if we 7 to foll[ our usual proc$ure4--7,f ! ,j\rnal ,a4 ,m4 ,a4 ,feb4 #af1 #aiah47 ,,article ,,vii ,%otgun ,no/rums ,=m]ly x 0 cu/om>y to prescribe mixtures ( _m drugs on ! assumption t if "o ( ! +r$i5ts miss$ ! m>k ano!r might be expect$ to hit x1 j z a poor m>ksman is m likely to hit a t>get at %ort range ) a blund]buss ?an ) a high p[]$ rifle4 ,increas$ precision 9 e bran* ( sci5ce has become ! out/&+ feature ( civilization4 ,! soldi] today mu/ %oot /raight ) a rifle t s5ds a s+le ball4 ,!re is none ( ! disposition to rely on *ance z :5 ! blund]buss 0 us$4 ,a capable physician directs 8 drug /raight at ! seat ( ! tr\ble1 & we n[ h _m drugs t c be dep5d$ on to ex]t def9ite actions4 ,! complex mixture is j z prepo/]\s 9 mod]n !rapeutics z ! blund]buss w\ld be on a mod]n battlefield4 ,e drug ex]ts undesir$ side actions1 & x is ! aim ( ! mod]n physician to try to select ! "o :i* w h a maximum ( !rapeutic ) a m9imum ( undesir$ actions4 ,:5 a complex mixture is employ$1 x is obvi\s t only ! be/ is utiliz$1 :]eas all ! undesir$ side actions come into play4 ,we d n pret5d t ev5 ! be/ /udi$ drug has n mu* to be le>n$ ab\t x2 b ! no/rum mak] :o exploits a complex mixture ei!r kn[s practically no?+ ( ! side actions t x w ex]t1 or1 if he kn[s1 he conceals t k4 ,he kn[s t massive doses ( hydrat$ *loral comb9$ ) v>i\s n>cotics c be reli$ on to cause unconsci\sness 9 ne>ly all cases1 b he pref]s to speak ( ?is z a hypnotic action4 ,?is is pla9 gambl+ ) human life4 ,:5 ! pati5t dies1 x is difficult to prove t dea? 0 caus$ by ! mixture alone4 ,! ,c\ncil on ,ph>macy & ,*emi/ry has exp5d$ a great deal ( "t & en]gy 9 combat+ ! 8%otgun0 no/rum evil4 ,x is easy to und]/& ! disadvantages ( su* mixtures b x is n s easy to demon/rate ! mislead+ "* ( ! claims made1 ) an entire disreg>d ( ! tru?1 = ^! mixtures4 ,no "o believes t a pot ( gold lies at ! end ( ! ra9b[1 b no "o has actually gone !re to see = himself4 ,,bromidia ,!re are _m types ( 8%otgun0 no/rum4 ,"s are dang]\s1 z 9 ! case ( 8,bromidia02 "s are prepo/]\s1 !rapeutic mon/rosities :i* excite ! contempt ( educat$ physicians1 z 9 ! case ( 8,tongal9e02 "s are m]ely useless mixtures ( well kn[n drugs1 sold "u grotesquely exagg]at$ claims1 z 9 ! case ( 8,peacock's ,bromides40 ,v>i\s =mulas h be5 giv5 = ,bromidia4 ,! manufactur]s appe> to be m cauti\s "u ^? circum/ances 9 :i* falsehood might lead !m into collision ) ! f$]al au?orities1 ?an :5 giv+ reign to fancy & consid]+ only ! be/ means ( w9n+ ! favor ( ! physician4 ,x is said to consi/ ( hydrat$ *loral1 potassium bromid1 ,indian cannabis1 & hyoscyamus4 ,x is impossible to det]m9e f ! publi%$ =mulas j h[ mu* hydrat$ *loral & potassium bromid x conta9s1 b is probable t !re are ab\t #ae gra9s ( ea* ( ^! two drugs to ! fluidram1 & v>iable am\nts ( ,indian cannabis & a small am\nt ( ei!r extract or t9cture ( hyoscyamus4 ,?is mu* is c]ta93 ,bromidia is a di/9ctly dang]\s mixture = indiscrim9ate use4 ,! claim ( ! manufactur]s1 impli$1 r ?an directly /at$1 t x is sup]ior to an extemporane\sly prep>$ mixture ( ^? drugs is especially repreh5sible because x t5ds to create ! impression t ! no/rum is saf] 9 effective doses1 conduc+ to a false s5se ( security on ! "p ( ^? :o are delud$ into prescrib+ x 9 l>g] doses ?an !y w\ld a mixture ( ! same drugs prep>$ extemporane\sly4 ,a report ( ! ,c\ncil on ,ph>macy & ,*emi/ry publi%$ 9 ,! ,j\rnal1 ,may #af1 #aiad1 p4 #aegc1 m5tions ?ree in/ances 9 :i* dea? is report$ to h foll[$ ! use ( ,bromidia4 ,! manufactur]s ( ,bromidia h no magic p[] to r5d] hydrat$ *loral h>mless1 :ile x reta9s its hypnotic action4 ,x depresses ! c5tral n]v\s sy/em1 & x is no?+ less ?an mon/r\s = any "o to pret5d to rob ?is drug ( its dang]\s prop]ties :ile x reta9s its hypnotic effects4 ,if ! pati5t requires a hypnotic1 ! physician %\ld *oose t "o :i* 8 judgm5t & exp]i5ce dictate z ! be/ = t p>ticul> pati5t4 ,if he ne$s hydrat$ *loral1 ! physician %\ld prescribe exactly z mu* z he believes ! pati5t ne$s4 ,if ! effect is slightly great] or slightly less ?an anticipat$1 no h>m is done & ! physician has ga9$ exp]i5ce t w be valuable 9 future prescrib+4 ,if ,bromidia is prescrib$ & unexpect$ effects are induc$1 x is impossible to "k :e!r ^! 7 due to ! hydrat$ *loral or to "o ( ! o!r n>cotics or to a syn]gi/ic action2 & !re is no?+ to guide 9 ! fur!r use ( ! no/rum1 = mixtures ( n>cotics commonly h mu* less uni=mity ( action ?an a s+le drug4 ,! irritant action ( hydrat$ *loral on ! /oma* c be avoid$ by ! use ( bl& fluids or dilute solutions4 ,! foll[+ s]ves z an example ( ! way 9 :i* x may be prescrib$ conv5i5tly3 ,gm4 or c4c4 ,hydrat$ *loral #bf gr4 xl ,syrup ( orange peel ,wat] ( ea* #cj fl i ,a tablespoonful 7#ae4j c4c47 ( ?is mixture1 conta9+ #aj gra9s 7#j4fe gm47 ( hydrat$ *loral1 w (t5 induce sleep 9 ! abs5ce ( sev]e pa9 or s]i\s di/urbance1 & seldom does ?is dose h to be repeat$ m ?an once 9 su* simple cases4 ,hydrat$ *loral is (t5 us$ 9 some:at small] doses 9 comb9ation ) potassium bromid1 :i* may be prescrib$ 9 a mixture su* z ! foll[+3 ,gm4 or c4c4 ,hydrat$ *loral #ac gr4 xx ,potassium bromid #ci gr4 lx ,syrup ( orange peel ,wat] ( ea* #cj fl i ,9 produc+ sleep :5 sev]e pa9 is abs5t ?is is z effective z ! prec$+1 9 simil> doses4 ,! use ( repeat$ doses ( hydrat$ *loral 9 su* a mixture z ?is1 or 9 ! =m ( ,bromidia or o!r no/rum :5 sleeplessness is due to sev]e pa9 is highly dang]\s4 ,x %\ld be rememb]$ t :ile hydrat$ *loral is an effective hypnotic 9 case ( simple sleeplessness1 x is n actively analgesic except 9 di/9ctly dang]\s doses4 ,bromidia 9 repeat$ doses w induce sleep ev5 9 ! pres5ce ( pa91 ( c\rse2 b any active n>cotic does t1 & x is correspond+ly dang]\s4 ,small doses ( morph9 giv5 alone are pref]able :5 sleeplessness is due to sev]e pa94 ,,tongal9e 8,tongal9e0 is an example ( ! type ( 8%otgun0 no/rum t w\ld be m]ely ludicr\s if we c\ld look on any?+ t degrades !rapeutics s lightly4 ,a report 0 made to ! ,c\ncil on ,ph>macy & ,*emi/ry1 & publi%$ 9 ,! ,j\rnal1 ,july #ag1 #aiae1 p4 #bfi1 & 9 ?is report x is /at$ t ,tongal9e is said to consi/ ( tonga1 cimicifuga racemosa1 sodium salicylate1 col*icum1 & piloc>p94 ,:e!r ! =mula 0 cut %ort j !re because ! (fice boy ran out ( brea? at t po9t1 or because ! discov]]s ( ?is wond]ful comb9ation _h n he>d ( ! em95tly pot5t sub/ances t ! wit*es add$ to _! cauldron1 we c leave to ! read]'s imag9ation1 = x is manife/ly impossible to pres5t an ord]ly discussion ( ! ph>macology & !rapeutics ( su* a prepo/]\s jumble ( drugs4 ,,peacock,s ,,bromides 8,peacock's ,bromides0 belongs to a slightly diff]5t class4 ,x is said to consi/ ( ! bromids ( sodium1 potassium1 ammonium1 calcium & li?ium4 ,9 ! abs5ce ( a logical explanation ( ! pret5d$ sup]iority ( ?is mixture ov] "o t is made extemporane\sly1 ! exploit]s seem to h be5 driv5 to ! necessity ( pret5d+ t its fre$om f contam9at+ *lorids expla9s its claim$ advantages ov] mixtures ( ! (ficial or comm]cial bromids4 ,! tru? is t ! *lorids are us$ z antidotes 9 bromid poison+4 ,disreg>d ! claims made = ,peacock's ,bromides1 & ask y\rself ! "q :e!r y h ev] actually se5 any ill results foll[+ ! use ( ! (ficial bromids t y c\ld reasonably attribute to contam9at+ *lorids4 ,fur!rmore1 c>efully consid] ! relative advantage ( a s+le bromid 7say ! bromid ( potassium1 or bromid ( sodium1 if y pref] x71 ) ! opportunity ( obs]v+ its effects & adju/+ ! dose 9 accordance ) ! results ( y\r exp]i5ce1 & a mixture su* z ,peacock's ,bromides1 ! composition ( :i* y d n "k1 & :i* ! manufactur] c alt] to suit 8 own conv5i5ce4 ,:ile x is true t ! !rapeutic art w n deg5]ate 9 its entirety m]ely because "s physicians cont9ue to use ! mo/ fraudul5t & wor?less no/rums1 yet1 on ! o!r h&1 to ! ext5t t a physician cont9ues to be guid$ by ! false tea*+s ( no/rum v5d]s :o h no !rapeutic tra9+1 he is plung$ into !rapeutic *aos4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,m>* #b1 #aiah47 ,,article ,,viii ,tyree's ,antiseptic & ,asept9ol ,x may seem p>adoxic to say t rec5t progress 9 ! m$ical sci5ces has made !rapeutic *aos possible1 b x is true nev]!less4 ,revolutions are sometimes sl[ & ord]ly1 sometimes sudd5 & att5d$ ) confusion4 ,! revolution>y *anges 9 ! m$ical sci5ces h be5 s num]\s & s rapid t ! g5]al practition] has be5 unable to keep pace ) !m1 & 9 ! result+ confusion ! no/rum mak] has se5 8 opportunity = exploit+ 8 useless1 dang]\s or unsci5tific prep>ations4 ,! great] ! confusion1 ! great] 8 opportunity2 & x is no exagg]ation to say t he has be5 ! mo/ pot5t factor 9 ma9ta9+ ! *aos ( !rapeutics4 ,! majority ( our read]s w\ld probably say t ! exi/+ sci5tific m$ical lit]ature insures ! p]man5ce ( e/abli%$ beliefs1 b e "o :o has delv$ into ! lit]ature has f\nd in/ances ( tru?s t _h be5 e/abli%$ & =gott5--buri$ "u ! ev]-increas+ avalan*e ( contributions to t lit]ature4 ,illu/ration3 ,typical half-page ,tyree adv]tisem5t appe>+ 9 m$ical j\rnals4 ,rapid advances are /ill be+ made 9 ! m$ical sci5ces & unless con/ant vigilance is ex]cis$ !rapeutics w return to ! *aotic condition f :i* x has s rec5tly em]g$4 ,x 0 9 recognition ( ^! facts--! dang] ( ?is return to *aos1 & ! difficulty1 9 fact1 impossibility1 ( any individual's keep+ pace ) all ( ! m$ical sci5ces--t ! ,am]ican ,m$ical ,association secur$ ! coop]ation ( m5 9 v>i\s bran*es ( m$ic9e 9 ! ,c\ncil on ,ph>macy & ,*emi/ry1 9 ord] t x may place ! results ( !rapeutic progress be=e ! read]s ( ,! ,j\rnal 9 an imp>tial mann]4 ,are y pr(it+ by ?is "w1 or are y /ill dep5d+ on y\r unaid$ ef=ts to di/+ui% ! false tea*+s ( ! no/rum v5d]s f t ( sci5tific m$ic9e8 ,are y prescrib+ 8,antikamnia0 & 8,ammonol0 or a simple memb] ( ! gr\p1 su* z acetanilid or ph5acet98 ,are y dep5d+ on 8,tyree's ,antiseptic10 s call$1 or are y us+ an antiseptic ab\t :i* !re is no my/]y1 = :i* no false claims are made1 & "o :i* is really effective8 ,9 %ort1 are y us+ drugs ( unque/ion$ value1 su* z are describ$ 9 8,useful ,drugs10 or are y tak+ y\r !rapeutic in/ructions f no/rum mak]s' circul>s8 ,p]haps y h be5 l$ to believe t ! ,c\ncil on ,ph>macy & ,*emi/ry is compos$ ( 8!ori/s0 & t ! no/rums repres5t ! "w ( 8practical m540 ,e "o %\ld /rive to be practical1 ( c\rse1 & x is wor? :ile to inquire :e!r sci5tific exp]im5t]s1 :o s l>gely mold m$ical lit]ature1 %\ld be t]m$ !ori/s1 or practical m54 ,a practical man practices t :i* is useful 9 ! treatm5t ( ! sick1 & he mu/ det]m9e :o is capable ( furni%+ him ) a bett] mat]ia m$ica4 ,a p]usal ( m$ical lit]ature w conv9ce any unbias$ m9d t m$ical sci5ce progresses only by means ( exp]im5t1 h5ce exp]im5t]s mu/ be consid]$ ! really practical m5 :ile ^? :o cl+ to outworn !ories are really ! 8!ori/s40 ,illu/ration3 ,typical ,asept9ol adv]tisem5t4 ,:5 ,li/] introduc$ antiseptic me?ods into surg]y he inaugurat$ a v]itable revolution1 :i* af=d$ ! no/rum mak]s opportunities = reap+ ri* h>ve/s ?r\gh ! exploitation--"u extraord9>y claims--( *eap mixtures ( little1 or no1 value4 ,!re is no lack ( antiseptics ( extraord9>y activity 9 ! te/ tube t are practically h>mless to man1 & x w\ld seem natural to suppose t su* antiseptics c\ld be us$ to control ! developm5t ( bact]ia 9 su* diseases z typhoid fev]1 b1 un=tunately1 su* hopes h n be5 fulfill$4 ,ehrli* exp]im5t$ ) _m ph5ol d]ivatives t %[$ decid$ antiseptic activity 9 ! te/ tube1 9 ! hope t he might f9d "s t c\ld be us$ to combat su* common diseases z diph!ria & typhoid fev]1 b :ile _m ( ^! are ( l[ toxicity = man1 he 0 unable to f9d ev5 "o t c\ld be us$ effectively 9 ! treatm5t ( any ( ^! diseases4 ,8 discov]y ( arsph5am9 78salv>san07 result$ f q ano!r type ( inve/igation4 ,_m practition]s lose sight ( ! ess5tial diff]5ce betwe5 antiseptics & dis9fectants & employ antiseptics 9 cases 9 :i* only a dis9fectant action w\ld be ( value4 ,an antiseptic does n de/roy bact]ia1 x m]ely inhibits _! gr[?2 & :5 x is dilut$ too mu*1 x loses its effects & ! bact]ia may beg9 to multiply z ?\gh no antiseptic _h be5 us$4 ,?is is especially true aft] ! use ( weak antiseptics 9 ! m\?4 ,^! are soon dilut$ or remov$ by ! saliva1 & ! bact]ia cont9ue to multiply ) only a mom5t>y int]ruption at be/2 h5ce to advise ! use ( an oral antiseptic z an effective means ( treat+ diph!ria is little %ort ( crim9al4 8,tyree's ,antiseptic ,p[d]0 0 submitt$ to ! ,c\ncil ne>ly twelve ye>s ago4 ,! label on ! package /at$3 8,?is prep>ation is a sci5tific comb9ation ( borate ( sodium1 alum51 c>bolic acid1 glyc]9 & ! cry/alliz$ pr9ciples ( ?yme1 eucalyptus1 gaul!ria & m5?a 9 ! =m ( a p[d]40 ,illu/ration3 ,"o ( ! old] newspap] adv]tisem5ts ( ,tyree's ,antiseptic ,p[d]4 ,a leaflet issu$ sev]al ye>s ago by ! ,asept9ol ,manufactur+ ,company /ates t 8,pulv4 ,asept9ol ,comp40 comb9es 9 an elegant =m boric acid1 ! salts ( alum9um1 cry/alliz$ ph5ol1 & ! active cry/all9e pr9ciples ( ?ymus1 m5?a & gaul!ria4 ,a comp>ison ( ^! =mulas w\ld ju/ify ! designation ( ! two prep>ations z tw9s1 b ev5 "o tw9 may h a w>t :]e ! o!r lacks x4 ,! =mula ( ,pulv4 ,asept9ol ,comp4 giv5 9 ! leaflet also includes ,hydra/is canad5sis1 b we believe t a w>t %\ld be q z mu* ( an addition to ! anatomy ( man z ! hydra/is is to ?is already prepo/]\s =mula4 ,simil> z ! =mulas ( ^! two no/rums 7 said to be1 ! g5]al me?ods ( exploit+ !m 7 ev5 m simil>4 ,a p>tial li/ ( ! diseases = :i* ea* has be5 recomm5d$ by its exploit]s %[s ! simil>ity ( me?ods pursu$3 ,,tyree',s ,,0 ,,said ,,to ,,be ,,useful ,,pulv4 ,,asept9ol ,,comp4 ,,0 ,,said ,,to ,,9 ,,! ,,treatm5t ,,(3 ,,be ,,useful ,,9 ,,! ,,treatm5t ,,(3 ,leucorrhea ,leucorrhea ,gonorrhea ,gonorrhea ,vag9itis ,vag9al inflammation ,pruritus ,pruritus ,ulc]at$ conditions ( ,ulc]ation ( vag9a or ! muc\s membrane c]vix ,scr(ul\s ulc]s ,*ronic ulc]s ,syphilitic ulc]s ,prophylactic aga9/ specific disease ,dis9fect+ (f5sive ,cleans+ pus cavities cavities ,deodorant ,deodorant ,pr(use & (f5sive ,*ecks abnormal secretion p]spiration ,we /at$ t ! =mula furni%$ by ,tyree 0 t giv5 above1 b ! ,c\ncil 0 nev] able to le>n :5 ,tyree actually employ$ ! =mula except = adv]tis+ purposes2 & analysis ( ! p[d] %[$ t ,tyree's ,antiseptic ,p[d] 0 ess5tially a mixture ( boric acid & z9c sulphate1 ) insignificant am\nts ( odor\s pr9ciples4 ,a rem>kable fact br\ght out 9 ! c\rse ( ! consid]ation ( ! prep>ation by ! ,c\ncil 0 t ,tyree admitt$ t he _h *ang$ ! =mula )\t hav+ publi%$ ! new "o4 ,! ,c\ncil !n %[$ t a specim5 ( ! 8antiseptic0 t _h be5 kept 9 a retail drug /ore = sev]al ye>s 0 ess5tially simil> to t sold at ! lat] date4 ,?us x w\ld seem t ,mr4 ,tyree _h be5 mak+ 8 p[d] by "o =mula & publi%+ an entirely diff]5t "o = ye>s be=e ! ,c\ncil publi%$ ! facts 9 ! case4 ,if ,tyree f\nd x necess>y to *ange ! =mula ( 8 p[d]--if inde$1 he ev] us$ ! publi%$ =mula--:y did ! ,asept9ol ,manufactur+ ,company adopt x1 or "o s closely resembl+ x8 ,x is obvi\s t bo? ( ^! tw9 no/rums are utt]ly unfit = treat+ ! v>i\s conditions = :i* !y are or h be5 recomm5d$2 & 9 view ( ! misrepres5tation 9 "o case1 x is difficult to und]/& :y x %\ld be tak5 z ! model = ! o!r4 ,d physicians believe t a simple mixture ( boric acid & z9c sulphate1 or a mixture su* z t giv5 9 ! =mula ( 8,asept9ol0 p[d]1 is 9 any way sup]ior to a prescription su* z any physician c\ld write8 ,!re is a f> m important "q to consid] ?an ! relative m]its ( su* no/rums & a prescription ( ! physician's own devis+4 ,t "q is :e!r ! m$ical pr(ession is go+ to help p]petuate ! *aotic conditions t ! use ( su* no/rums fo/]s or to assi/ 9 !rapeutic progress by ma9ta9+ its indep5d5ce ( su* false tea*]s1 & seek+ to aid 9 ! e/abli%m5t ( a rational use ( drugs & rem$ial measures4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,m>* #cj1 #aiah47 ,,article ,,ix ,neuros9e & ! ,orig9al ,package ,evil ,we call$ att5tion rec5tly to ! skill :i* ! no/rum v5d] displays 9 avoid+ ! p>ticul> ?orn t pricks him1 & 8 developm5t ( ! art ( impressively say+1 8,no?+ 9 ,g5]al10 z exemplifi$ 9 ! adv]tisem5ts ( ,fell[s' ,syrup4 ,no/rum sell]s are m canny ?an orig9al2 & :5 once an idea f9ds lodgm5t ) "o ( !m1 x is made to s]ve _m ma/]s4 ,=m]ly exploit]s ( ei!r vici\s or wor?less no/rums 7 wont to boa/ t _! prep>ations 7 exploit$ 9 a 8/rictly e?ical mann]40 ,rec5t p]usal ( z *oice a lot ( adv]tisem5ts z c be f\nd 9 ! mo/ degrad$ ( m$ical j\rnals fail$ to disclose ?is claim 9 a s+le in/ance1 al?\gh ! claim t a prep>ation is 8adv]tis$ only to physicians0 is /ill common4 ,! adv]tisem5t ( 8,neuros9e10 :i* we reproduce1 0 ! fir/ "o :i* came to our att5tion :5 we se>*$ ?r\gh "s m$ical j\rnals = "o t w\ld illu/rate a discussion ( ! 8orig9al package0 evil4 ,?is is ! only reason = select+ ,neuros9e r ?an ano!r4 ,su* half page adv]tisem5ts & o!rs ( simil> size 9 v>i\s m$ical j\rnals co/ a good deal ( money & !y presuppose t ! ,dios ,*emical ,company is int]e/$ 9 hav+ orig9al bottles ( ,neuros9e disp5s$ e "t t no/rum is prescrib$4 ,:y %\ld ! firm h any su* deep int]e/ 9 see+ t an orig9al bottle gets to ! pati5t8 ,:y %\ld x be necess>y to d any?+ m ?an see t ! g5u9e mixture rea*es ! pati5t8 ,does x seem )9 ! b\nds ( reason t sub/itution is s commonly practic$ by ph>maci/s t ?is firm mu/ g to l>ge exp5se to prev5t ! sub/itution ( spuri\s mixtures = its product8 ,is di%one/y ! rule among ph>maci/s8 ,common s5se rejects ! plea z plac+ too great a /ra9 on "o's cr$ulity4 ,obvi\sly1 !n1 ! adv]tisem5t does n tell ! :ole tru?1 ?\gh x does inde$ tell exactly :at ! no/rum mak] wi%es to h done1 t is1 to h only orig9al bottles disp5s$ :5 physicians prescribe t no/rum4 ,! fact we h2 ! reason is n f> to seek4 ,illu/ration ,:5 ! ph>maci/ puts up an ord9>y1 nonpropriet>y prescription1 ! pati5t gets no clue f ! package z to ! nature ( ! prescription employ$4 ,b :5 an orig9al bottle ( ,neuros9e is disp5s$1 ev5 ?\gh ! ph>maci/ puts 8 own prescription label on x1 ! pati5t sees ! diff]5ce at once & kn[s j :y ! usual prescription bottle 0 n employ$4 ,he also kn[s t he c get ! m$ic9e ) its orig9al wrapp] or label by m]ely %[+ ! bottle to ! druggi/1 = ! words 8,neuros9e0 & 8,dios ,*emical ,co40 are bl[n 9 ! glass4 ,"h1 !n1 may be a plausible reason = desir+ t only orig9al bottles be disp5s$4 ,y may ask1 8,:at diff]5ce does x make if ! pati5t does le>n ! "n ( ! no/rum1 he mu/ g to 8 physician = advice conc]n+ its use80 ,hav+ le>n$ ! "n ( ! rem$y t has be5 prescrib$ = sleeplessness1 let u say1 he proce$s to use x :5ev] he imag9es t he ne$s x2 & t ne$1 real or imag9>y1 has a way ( increas+ 9 frequ5cy4 ,z a result1 ! pati5t takes f> m ,neuros9e ?an ! physician w\ld ?9k ( p]mitt+ if ! matt] _h n pass$ entirely beyond 8 control4 ,n only has ! pati5t acquir$ a dang]\s habit ( self-prescrib+1 b he takes especial delight 9 recomm5d+ 8 favorite rem$y to fri5ds ^: symptoms1 real & imag9>y1 seem to resemble 8 own4 ,?is (f]s him an opportunity to prescribe ) an air ( au?ority4 ,x 0 prescrib$ = him by ,dr4 ,blank1 & x gave relief1 ergo x may be dep5d$ on to give relief to o!rs6 ,?us is ! basis laid = its g5]al use by ! laity1 :5 ?is process is multipli$ suffici5tly4 ,! /atem5t is susceptible ( easy pro( by any "o :o c>es to inve/igate ! matt] = himself4 ,!re is probably no physician wor?y ( ! "n :o w attempt to d5y t ! promiscu\s use ( hypnotics & n>cotics is dang]\s1 & c]ta9ly no c>eful physician w delib]ately place a n>cotic 9 ! h&s ( pati5ts to be us$ freely & )\t control4 ,s9ce we h select$ ,neuros9e at r&om1 s f> z ?is p>ticul> discussion is conc]n$1 x is wor? :ile to inquire into its composition1 ! claims t h be5 made = x & ! evid5ce1 if any exi/s1 = or aga9/ its !rapeutic value4 ,ev5 ! mo/ active ( hypnotics are worse ?an useless if !y are inf]ior to o!r readily available hypnotics1 or if !y h undesir$ side-actions t outweigh any advantages t !y might o!rwise h4 ,! ,c\ncil on ,ph>macy & ,*emi/ry inve/igat$ ! lit]ature relat+ to ,neuros9e & publi%$ its report 9 ,! ,j\rnal1 ,jan4 #i1 #aiae1 p4 #afe4 ,accord+ to ?is report ! manufactur]s ( ,neuros9e claim$ t ea* fluid\nce conta9$3 ,bromid ( potassium1 ,c4 ,p4 #dj gra9s ,bromid ( sodium1 ,c4 ,p4 #dj gra9s ,bromid ( ammonium1 ,c4 ,p4 #dj gra9s ,bromid ( z9c #a gra9 ,extract lupul9 #cb gra9s ,casc>a sagrada1 fl4 ex4 #dj m9ims ,extract h5bane #j4jge gra9 ,extract belladonna #j4jge gra9 ,extract cannabis indica #j4fj gra9 ,oil bitt] almonds #j4fj gra9 ,aromatic elixir ,?is *emical blund]buss 0 recomm5d$ = use 9 insomnia1 hy/]ia1 neura/h5ia1 migra9e1 neuralgia1 delirium trem5s1 epilepsy & _m o!r conditions4 ,also x 0 call$ an ideal calmative = *ildr5 suff]+ f *orea1 ! exploit]s claim+ t 8,all au?orities recomm5d ! bromids1 hyoscyamus & cannabis indica 9 ?is disease40 ,oliv] ,t4 ,osborne1 pr(essor ( !rapeutics 9 ,yale ,m$ical ,s*ool1 does n m5tion "o ( ^! ?ree drugs 9 8 discussion ( ! ,m$ic9al ,treatm5t ( ,*orea1 9 ! ,h&book ( ,!rapy1 ?\gh he quotes sev]al au?orities 9 ?is article4 ,inde$1 he does n m5tion "o ( ! t5 drugs includ$ 9 ! above =mula ( ,neuros9e 9 connection ) ! treatm5t ( ?is disease4 ,x is a curi\s fact t ,osborne gives ! greate/ prom95ce to ! use ( t drug :i* is claim$ to be want+ 9 ! =mula ( ,neuros9e1 namely1 hydrat$ *loral4 ,p]haps y may h se5 tempor>y relief foll[ ! adm9i/ration ( ,neuros9e 9 *orea1 & may argue t !oriz+ is ( little value 9 ! face ( p]sonal exp]i5ce4 ,we %all n d5y t "s may h _h t exp]i5ce1 = ,osborne calls att5tion to ! fact t ! success ( any m$ic9al treatm5t mu/ be judg$ 9 ! light ( ! fact t *orea is self-limit$1 & ! int5sity ( ! symptoms w abate 9 f two to f\r weeks4 ,9 view ( ?is1 we w\ld h>dly dispute ! claim t "o may adm9i/] n>cotics1 su* z ^? conta9$ 9 ,neuros9e1 & ! symptoms ( *orea may abate 9 spite ( su* mi/reatm5t4 ,9 all ! ye>s t ,neuros9e has be5 exploit$ to physicians ) su* rem>kable claims1 we h nev] se5 a report ( a c>eful cl9ical /udy 9 :i* ! product has be5 us$ "u ! conditions :i* sci5tific inve/igation dem&s4 ,w\ld y prescribe any nonpropriet>y prep>ations :i* _h nev] be5 /udi$ cl9ically1 if a horse-%o] or groc]'s boy told y x w\ld cure epilepsy or mal>ia8 ,accord+ to an editorial note app5d$ to ! report ( ! ,c\ncil on ,neuros9e1 ! ,dios ,*emical ,company consi/$ at t "t 7#aiae7 ( ,j4 ,h4 ,*amb]s1 8 wife & two sons4 ,x appe>$ t ,*amb]s nev] claim$ to h any special k ( *emi/ry1 ph>macy or m$ic9e1 yet we f9d t he arrogat$ to himself or to 8 employees ! "r to (f] !rapeutic advice to ! m$ical pr(ession1 & ev5 to direct !m z to h[ !y %\ld prescribe a giv5 mixture4 ,we sometimes fail to see ! =e/ because ( ! trees4 ,x may help u to obta9 a bett] p]spective1 9 a problem t conc]ns u intimately1 by resort+ to a hypo!tic case1 if a close analogy is ma9ta9$4 ,9 ord] t we may see ourselves z o!rs see u 9 su* a situation1 let u consid] ! foll[+ imag9>y case3 ,y become involv$ 9 a lawsuit 9 :i* an ef=t is made to deprive y ( y\r prop]ty & y\r lib]ty4 ,y seek :at y _h reason to believe 0 compet5t legal advice2 b1 nev]!less1 y lose y\r case & f9d y\rself depriv$ ( y\r prop]ty & y\r lib]ty4 ,n[ let u suppose fur!r t y discov]1 :5 too late to p]mit y to correct y\r mi/ake1 t y\r legal advis] 7we c h>dly call su* a man a lawy]7 _h be5 act+ all along "u ! guidance ( a plumb] :o made no pret5se ( kn[+ any?+ ab\t law4 ,h[ w\ld y feel reg>d+ t pret5d$ lawy]8 ,w\ld y feel t y _h be5 treat$ fairly8 ,w\ld y feel dispos$ to speak ) all *>ity ( him1 to recomm5d him to ^? 9 ne$ ( legal advice8 ,y w\ld probably feel t[>d su* a lawy] z pati5ts mu/ feel t[>d physicians :o prescribe propriet>y no/rums bas$ on in=mation & advice (f]$ by ^? :o1 ?\gh )\t any special k ( *emi/ry1 ph>macy or m$ic9e1 w be b5efit$ f9ancially if _! in=mation & advice are accept$ & act$ on4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,april #bg1 #aiah47 ,,anas>c9 ,,adv]tis+,i ,i ,see index = o!r articles on ,anas>c94 ,to ! ,editor3--,z an old ,fell[ ( ! ,a4 ,m4 ,a4 ,i beg to pres5t ! foll[+ facts to y1 & to ask if any?+ c be done by y to expose ! me?ods ( ^! p3 ,a conc]n call+ itself 8,! ,anas>c9 ,*em4 ,co40 ( ,w9*e/]1 ,t5n41 has caus$ to be s5t to physicians a *>t on ! subject ( 8,diagno/ics ( ,r5al ,diseases40 ,?is *>t conta9s eighte5 plates1 :i* 7 all tak5 )\t k or p]mission ( ei!r myself or my publi%]s1 ,william ,wood ,co41 f ! ?ird edition ( my book on 8,ur9>y ,analysis & ,diagnosis40 ,! plates are p>tly composite plates1 b mo/ly portions ( plates1 exactly reproduc$ f my book4 ,i at once caus$ my publi%]s to write to ! ,anas>c9 ,company2 & a few days ago ,i receiv$ a lett] f a ,dr4 ,h4 ,elliott ,bates ( #aah ,ea/ ,tw5ty-,eigh? ,/reet1 ,new ,york1 ^: lett]head says1 8,m$ical ,adv]tis+40 ,9 ?is lett] ! writ] says t x 0 he :o sugge/$ ! s5d+ ( su* a *>t1 & admits t all ! plates 7 tak5 f my book4 ,9 ?is lett] he (f]s to h a lett] s5t to e physician ( ! c\ntry 89 :i* x is explicitly /at$ t ! cuts on ! *>t 7 tak5 f y\r book1 & t complete in=mation reg>d+ ! matt]s treat$ on ! *>t c be f\nd 9 y\r book40 ,9 o!r words he (f]s to adv]tise my book free ( co/ to me1 s t ,i %\ld take no fur!r /eps 9 ! matt]4 ,i consid] ?is entire matt] an outrage1 & ?\ght x be/ to write to y = advice1 s9ce my publi%]s seem to ?9k t 9 spite ( ! violation ( ! copyright no?+ c be done4 ,besides ! cuts1 "s ( ! text on ! *>t is bodily tak5 f my book1 :ile "s ( ! o!r text1 n tak5 f my book1 b app>5tly compil$ f diff]5t articles1 is 9 "p entirely wrong1 s mu* s t ,i mu/ be a%am$ ( its be+ associat$ ) any ( my own "w4 ,by giv+ ?is lett] y\r e>ly consid]ation1 & advis+ me :at y ?9k x be/ = me to d1 y w\ld greatly oblige ,l\is ,heitzman1 ,m4,d41 ,new ,york4 ,comm5t4--,read]s ( ,! ,j\rnal are1 ( c\rse1 famili> ) ! articles#bdf t h be5 publi%$ on 8,anas>c910 ! 8dropsy cure06 ,kn[+ ! /&>d ( e?ics t ! ,anas>c9 conc]n adopts 9 ! exploitation ( its ridicul\s squill mixture1 our read]s w n be surpris$ at ! /&>d ( comm]cial e?ics :i* w\ld ju/ify ! appropriation ( copyright$ sci5tific mat]ial = no/rum adv]tis+ purposes4 ,! /atem5t ( ,dr4 ,heitzmann's publi%]s t 89 spite ( a violation ( copyright no?+ c be done0 is1 ( c\rse1 incorrect4 ,some?+ c be done by ^? :o hold ! copyright4--,ed4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,oct4 #ah1 #aiai47 #bdf ,j4 ,a4 ,m4 ,a4 #df3bhh 7,jan4 #bg7 #aijf2 ibid4 #dh3aece 7,may #d7 #aijg2 ibid4 #dh3afad 7,may #aa7 #aijg1 & ibid4 #di3aiib 7,dec4 #h7 #aiag4 ,,antim]i/em-,,s*midt ,"s1 possibly _m1 ( our read]s h receiv$ a lett] f ,cologne1 ,g]many1 f ! 8,bakt]iologis*-,*emis*es ,laboratorium ,wolfgang ,s*midt40 ,! lett] conta9s a circul> direct+ ! att5tion ( ,am]ican physicians to 8,antim]i/em-,s*midt40 ,x also conta9s "s adv]tis+ leaflets4 ,"o physician 9 s5d+ ?is mat]ial to ,! ,j\rnal writes3 8,a copy ( ! enclos$ circul>s has be5 s5t to _m ( ! physicians 9 ?is city1 & probably else:]e4 ,p]haps x has already be5 call$ to y\r att5tion4 ,let u be z lib]al z possible ) our rec5t enemies4 ,! soon] ! old *annels ( sci5tific communication are re-op5$1 ! bett]4 ,b let u n all[ su* blatant comm]cialism f a =eign c\ntry to g unprote/$1 any m ?an we %\ld if x 7 f our own40 ,x %\ld be not$ 9 pass+ t ! envelop 9 :i* ! ,wolfgang ,s*midt lett] came has on its face a rubb]-/amp$ impress to ! effect3 8,conc]ns ,canc] ,treatm5t40 ,! circul> lett] decl>es t by means ( ,antim]i/em-,s*midt 8ei!r a cure or improvem5t has be5 effect$ 9 num]\s inop]able cases0 ( malignant tumors4 ,am]ican physicians are ask$ 8to employ ! prep>ation :5 occasion arises0 & are assur$ t 8e m$ical man 9 city or c\ntry w be able to c>ry out treatm5t )\t prelim9>y k40 ,) ! lett] are two leaflets discuss+ ! use & adm9i/ration ( ! product2 "o conta9$ :at 0 call$ a 8,synopsis ( "s ( ! m rec5t publications reg>d+ ! employm5t ( ,antim]i/em-,s*midt 9 inop]able malignant tumors40 ,! 8rec5t0 publications compris$ ?ree articles publi%$ 9 #aiaj & "o publi%$ 9 #aiab6 ,antim]i/em-,s*midt 0 r widely exploit$ "s six or sev5 ye>s ago4 ,z 0 expla9$ 9 ,! ,j\rnal1 ,m>* #h1 #aiac1 p4 #gff1 x is a prep>ation claim$ to be useful 9 ! treatm5t ( inop]able canc] & z a supplem5t>y treatm5t aft] op]ations = canc]4 ,! treatm5t is f\nd$ on a !ory advanc$ by "o ,o4 ,s*midt t ! cause ( canc] is f\nd 9 a fungus1 ,mucor racemosus1 :i*1 ,s*midt at fir/ ass]t$1 c>ri$ a protozoon :i* he reg>d$ z ! real cause ( ! disease4 ,! vacc9e is said to be prep>$ f cultures f ?is fungus4 ,:ile ,s*midt claims t he has be5 able to produce canc] by means ( ! organism1 sci5tific rese>* has n v]ifi$ 8 claims4 ,ext5sive cl9ical trials h %[n ! treatm5t to be )\t effect4 ,! ,j\rnal also advis$ its read]s on ,april #ai1 #aiac1 t no lic5se = ! sale ( ,antim]i/em-,s*midt _h be5 grant$ by ! ,treasury ,dep>tm5t &1 !re=e1 its importation into ?is c\ntry 0 prohibit$4 ,nei!r ! !rapeutic nor ! legal /atus ( ! product has be5 *ang$ s9ce !n4--7,f ,! ,j\rnal ,a4,m4,a41 ,dec4 #f1 #aiai47 ,,antiphlogi/9e ,to ! ,editor3--,la/ ,septemb]1 my *ief1 ,dr4 ,j4 ,s4 ,mill>d1 receiv$ a lett] f ! ,d5v] ,*emical ,mfg4 ,co41 manufactur]s ( 8,antiphlogi/9e40 ,?is lett] purport$ to quote _m l>ge comm]cial conc]ns z te/ify+ to ! value ( ,antiphlogi/9e4 ,rec5tly1 ,i d\bt$ ! v]acity ( ^! claims & wrote to "s ( ^? quot$4 ,i quote f ! orig9al lett] ( ! ,antiphlogi/9e company3 8,! surgeon to ! electric light & electric railroad company 9 ,new ,orleans says t ,antiphlogi/9e is ! f9e/ ?+ he has ev] us$ 9 burns1 especially fla% & bru% burns4 8,! physician to ! ,new ,york ,edison ,co4 makes a simil> /atem5t4 ,he says t ! application gives spe$y relief & ! burns heal quickly )\t sc>s40 ,i wrote to ,dr4 ,john ,woodman1 ! physician to ! ,new ,york ,edison ,co41 :o repli$ 9 "p z foll[s3 8,! ,d5v] ,*emical ,manufactur+ ,company h no au?ority to quote me4444 ,i gave ,antiphlogi/9e a ?or\gh trial1 & f\nd x _h a v limit$ use1 & ,i _c recomm5d x = burns44440 ,aga91 ! ,antiphlogi/9e lett] said3 8,x may be ( int]e/ to y to "k t at ! em]g5cy hospital ( ! ,=d ,automobile ,co4 9 ,detroit1 ,antiphlogi/9e is c>ri$ 9 /ock & is us$ ext5sively by ! ?ree physicians 9 burns1 bruises1 infect$ w\nds1 spra9s & o!r traumatic conditions :i* are con/antly aris+ 9 su* a plant44440 ,i wrote to ,dr4 ,mead :o repli$ z foll[s3 8,9 answ] to y\r lett] ( ,janu>y #be?1 w /ate t no ,antiphlogi/9e has be5 pur*as$ or us$ 9 ?is hospital = ye>s pa/1 & ,i _c imag9e :y ! repres5tative ( ! ,d5v] ,*emical ,company %\ld make su* a /atem5t z attribut$ to him44440 ,he adds t 8,antiphlogi/9e has nev] be5 us$0 9 8 dep>tm5t 8on an op5 w\nd1 abrasion or burn40 ,is !re n "s way t su* exploitation ( our l>ge companies c be prev5t$8 ,a4 ,g4 ,g\ld1 ,m4,d41 ,akron1 ,ohio4 ,plant ,physician1 ! ,goodye> ,tire ,rubb] ,co4-7,f ! ,j\rnal ,a4,m4,a41 ,feb4 #bc1 #aiah47 8,,auto-,,hemic ,,s]um0 ,a ,cure = ,laz9ess1 ,ugl9ess1 ,frigidity & ,_m ,o!r ,?+s ,! foll[+ lett]s are typical ( _m t h be5 receiv$ ask+ = in=mation reg>d+ ,dr4 ,l4 ,d4 ,rog]s & 8 8,auto-,hemic ,s]um40 ,?is f a physician 9 ,new ,york /ate3 8,c y give me any in=mation 9 ref]5ce to ,dr4 ,rog]s ( ,*icago1 ,ill41 :o has an ,auto-,hemic ,in/itute80 ,& ?is f ,kansas3 8,j receiv$ a lett] f a ,dr4 ,l4 ,d4 ,rog]s1 #bhab ,nor? ,cl>k ,/41 :o is anxi\s to sell me a c\rse 9 #8,auto-,hemic ,!rapy4' ,w\ld y k9dly in=m me :at he has to sell8 ,he did n tell me :at x consi/$ (2 am incl9$ to believe x is a rank fake4 ,k9dly let me "k :at ,! ,j\rnal ?9ks ab\t x4 ,j :at is x8 ,9 ! lett] !y claim t x is practically a panacea = e blood disease40 ,?is f ,ma9e3 8,:at is ,auto-,hemic ,!rapy8 ,i h a h&some r$ & yell[ circul> f ! ,ideal ,life ,ext5sion ,press1 #bhab ,nor? ,cl>k ,/41 ,*icago1 solicit+ subscriptions to _! publication1 (f]+ z a bonus ?is book1 #8,auto-,hemic ,!rapy' by ,l4 ,d4 ,rog]s1 ,a4,m41 ,m4,d41 ,,ll4,d41 ,*icago1 & memb]%ip 9 ! ,am]ican ,m$ical ,union40 ,,! ,,national ,,m$ical ,,univ]sity ,9 ord] bett] to appreciate ! probable sci5tific /atus ( 8,auto-,hemic ,s]um10 x is well briefly to sket* "s ( ! previ\s activities ( its discov]]1 ,dr4 ,l4 ,d4 ,rog]s4 ,= _m ye>s ,rog]s 0 ! head & *ief own] ( ! ,national ,m$ical ,univ]sity ( ,*icago1 a l[-grade s*ool ( ! 8sun-d[n0 v>iety4 ,! 8univ]sity0 is n[ out ( exi/5ce & = "s "t be=e x w5t out ( exi/5ce 0 n recogniz$ ei!r by ! bo>d ( heal? ( ! /ate 9 :i* x op]at$ or by ! bo>ds ( ! majority ( ! o!r /ates 9 ! ,union4 ,! report ( ! ,c>negie ,f\ndation on m$ical education _h ?is to say ab\t ! laboratory facilities ( ,rog]s' s*ool3 8,! s*ool occupies a badly light$ build+1 conta9+ no?+ t c be dignifi$ by ! "n ( equipm5t4 ,!re has be5 no dissect+ ?us f> 7,octob] to ! middle ( ,april1 #aiji71 anatomy be+ didactically taught4 ,p]si/5t inquiry = ! #8dissect+-room' 01 h[ev]1 f9ally rew>d$ by ! sight ( a dirty1 unus$1 & almo/ inaccessible room conta9+ a putrid corpse1 sev]al ( ! memb]s ( :i* _h be5 hack$ (f4 ,!re is a l>ge room call$ ! *emical laboratory1 its equipm5t #8lock$ up1' ! tables spotless4 #8,ab\t t5' oil-imm]sion microscopes are claim$--also #8lock$ up 9 ! /or]oom4' ,!re is n ev5 a pret5se ( any?+ else4 ,classes 9 session 7 all tak+ dictation40 ,dr4 ,rog]s is1 or 01 if he is n /ill1 8,p]man5t ,secret>y0 ( ! 8,national ,association ( ,panpa?ic ,physicians0--:atev] t is4 ,9 fact1 "o ( ,dr4 ,rog]s' specialties seems to be ! f\nd+ ( quasim$ical organizations--organizations1 app>5tly1 :i* may prove useful 9 ! promulgation ( su* projects z he may1 at ! "t1 be int]e/$ 94 ,a few ye>s ago1 ,rog]s 0 exploit+ a 8canc] s]um0 &1 pre/o1 ! 8,am]ican ,canc] ,rese>* ,society0 came into be+1 ,l4 ,d4 ,rog]s1 presid5t4 ,soon !reaft] c]ta9 memb]s ( ! pr(ession 7 circul>iz$ urg+ !m to pur*ase %>es 9 ! 8,canc] ,rese>* ,laboratory & ,hospital10 p> value #aj4 ,app>5tly1 ! pr(ession did n inve/4 ,a few ye>s ago1 also1 ,l4 ,d4 ,rog]s' "n appe>$ on ! 8,faculty0 li/ ( ! 8,am]ican ,po/-,graduate ,s*ool10 a conc]n :i* grant$--on ! mail-ord] plan--a long l9e ( sonor\s degrees & an equally complete l9e ( ornate diplomas4 ,,! ,,japanese ,,consumption ,,cure ,!n1 9 #aiae1 !re appe>$ 9 ! classifi$ columns ( c]ta9 newspap]s ! foll[+ adv]tisem5t3 ,,tub]culosis--,new ,japanese treatm5t2 to prove m]its & give discov]y quick publicity w s5d #aj days' treatm5t free4 ,,dr4 ,,rog]s1 #edf ,surf ,/41 ,*icago4 ,s f> z we h be5 able to le>n1 ,rog]s1 = "s unexpla9$ reason1 did n call into exi/5ce out ( ! va/ly deep a 8,japanese-,am]ican ,tub]culosis ,rese>* ,society40 ,?is consumption cure app>5tly di$ ( inanition4 ,!n came ! 8,auto-,hemic ,s]um0 ) its inevitable sequel1 ! 8,national ,society ( ,auto-,hemic ,practition]s40 ,ano!r adjunct to ! s]um exploitation is ! ,nor? ,am]ican ,j\rnal ( ,homeopa?y1 ! (ficial organ ( ! 8,auto-,hemic ,practition]s0 & ( ! 8,am]ican ,m$ical ,union0 & possibly ( "s o!r 8societies0--b n repres5tative ( homeopa?y6 ,,:at ,,is ,,auto-,,hemic ,,!rapy ,:at is ?is new !rapy8 ,accord+ to a v lurid po/]1 x is describ$ z 8,! ,miss+ ,l9k 9 ,m$ic9e0--possibly ref]r+ to ! ease ) :i* "o may make monkeys ( c]ta9 physicians4 ,m specifically1 al?\gh /ill vaguely1 we le>n3 8,x consi/s 9 giv+ ! pati5t a solution made by att5uat+1 hemoliz+1 incubat+ & pot5iz+ a few drops ( 8 or h] own blood1 & adm9i/]+ x accord+ to a ref9$ te*nic develop$ by ! au?or40 ,else:]e x is said to consi/3 8444 9 tak+ five drops 7or "s multiple ( five7 ( blood f a ve9 & putt+ x into n9ete5 times z mu* /]iliz$1 di/ill$ wat]1 & incubat+ x at fev] temp]ature = tw5ty-f\r h\rs1 & !n mak+ fur!r dilutions accord+ to ! ne$s ( ! case1 z c be det]m9$ only by a physician skill$ 9 its use40 ,nei!r ( ^! /atem5ts1 ( c\rse1 describes ! 8ref9$ te*nic0 ( ^? 8skill$ 9 its use10 b ^? :o are int]e/$ c1 by s5d+ ,dr4 ,l4 ,d4 ,rog]s1 8,"o ,hundr$ ,doll>s ca%-9-advance0 get a mail-ord] c\rse 9 ?is new m>vel4 ,b if x is r exp5sive to le>n j h[ to use 8,auto-,hemic ,s]um10 x does n co/ s mu* to le>n :at ! 8s]um0 w d4 ,rog]s has writt5 a book on ! subject1 8,auto-,hemic ,!rapy10 :i* is us$ z a premium = subscriptions to ! ,nor? ,am]ican ,j\rnal ( ,homeopa?y1 price #e4jj p] ye>1 payable 9 advance4 ,9 ! book ,dr4 ,rog]s mode/ly assures 8 read]s t he consid]s 8 discov]y m important ?an t ( ,alexis ,c>rel1 w9n] ( a ,nobel ,prize4 ,a ,,cure ,,= ,,laz9ess ,"o ( ! *ief virtues claim$ = ?is s]um is t ( develop+ 9 ! pati5t :o takes x an unb\nd$ en]gy t1 app>5tly1 makes him want to "w himself to dea?4 ,9 "s s5sational articles t h appe>$ 9 ,sunday editions ( newspap]s on ,rog]s' s]um1 ! /uff has be5 describ$ z 8,lazy ,s]um40 ,"o ( ! fir/ cases describ$ 9 ! ,rog]s book is t ( a "y wait]1 8a good-=-no?+ lazy fell[ :o w\ld n "w & w\ld n pay = m$ical s]vices0 & :o 0 turn$ ov] to ,dr4 ,rog]s' free cl9ic4 ,he 0 giv5 ! s]um on ,?ursday & 0 told to report ,saturday4 ,he did n return until ,monday1 8 excuse be+ t 8he work$ all day ,saturday until midnight & all day ,sunday & felt z if he c\ld "w all day & all night )\t re/40 ,! 8case report0 ends3 8444 f9ally rem>k+1 #8,i feel l a bird' he flew out ( ! classroom & we nev] saw him aga940 ,,h\sewives ,,take ,,notice ,! next case describ$ is t ( a s]vant girl :o _h n work$ = a ye>2 )9 a week aft] tak+ ! 8,auto-,hemic ,s]um10 8%e volunt>ily beat c>pets till %e bli/]$ h] h&s40 ,!n !re 0 ! room+ h\se keep] :o _h sp5t m ?an half ( ea* day 9 b$4 ,aft] an 8,auto-,hemic0 injection %e 8dis*>g$ h] maid & janitor 444 & did all ! "w ( h] twelve room h\se h]self1 beat+ rugs1 fir+ furnace & c>ry+ out a%es besides do+ "s ( ! laundry40 8,case ,no4 #gagf0 is int]e/+3 ,a man1 g5]ally consid]$ ! lazie/ p]son 9 8 community & ) a habit ( 8dr9k+ ?irty :iskies a day10 took 8,auto-,hemic ,s]um40 ,he /opp$ dr9k+1 %av$ himself & *ang$ f 8a 8bum0 to t ( a sob]1 clean1 :olesome1 bright & hone/ workman40 ,!n !re 0 ! case ( ! 8lady physician0 :o 8took ! s]um "o ev5+ & ! next morn+ report$ t %e _h ! #8giggles' all day02 also %e became 8m magnetic40 ,m rem>kable /ill 0 ! case ( ! "y woman cl]k 9 a retail /ore :o1 aft] tak+ ! s]um1 8a/oni%$ h] employ] by volunte]+ to "w ov]time40 ,9 ! *apt] deal+ ) 8,ills ,peculi> to ,wom50 ,dr4 ,rog]s details ! mov+ /ory ( a man to :om ! 8s]um0 0 giv5 & :o report$ t 8ab\t ! ?ird tw5ty-f\r h\rs aft] tak+ x 8 b[els mov$ =ty times0--nev]!less1 8he felt no exhau/ion40 ,9 all phases ( human activity ! s]um seems to "w wond]s4 8,! cases are num]\s 9 :i* ! frigidity ( bo? sexes h sic melt$ aft] ,auto-,hemic treatm5t40 ,a "y m>ri$ woman ) a morbid dislike = h] husb& took ! s]um & )9 a week 8became normal40 ,! discov]] sugge/s t 9 "s cases !re is no d\bt t ?is s]um 8w\ld prev5t divorce40 ,a #dj ye> old woman :o c\ld n endure to we> any wai/s b :ite or black 0 able1 x seems1 aft] tak+ ! s]um to tol]ate a v]itable ,jacob's coat4 ,is1 !n1 8,auto-,hemic ,s]um0 good = ev]y?+8 ,let ,dr4 ,rog]s answ]3 8,briefly /at$1 )\t any great exagg]ation1 ?is new modifi$ s]um treatm5t is good = any?+ t is ! matt] ) y1 provid$ ! cause is n organic1 me*anical or bact]ial40 ,"o inf]s t 9 ! inorganic1 m5tal1 spiritual & nonbact]ial sph]es ! /uff is supreme4 ,b x has its limitations4 ,= in/ance1 ,dr4 ,rog]s /ates t he once _h 8a v tr\blesome c\gh :i* la/$ sev]al weeks1 b did n yield to ?is s]um40 ,rea*+ ! conclusion t "s o!r treatm5t 0 necess>y 8he _h ! bones ( 8 neck #8adju/$' & got imm$iate relief40 ,,z ,a ,,complexion ,,beautifi] ,! s]um 8_c be made up by ! b>rel & sold at :olesale or retail03 8,if x c\ld be bottl$ & /or$ & sold at retail l a pat5t m$ic9e1 ! dem& = x z a complexion beautifi] alone w\ld net ! proprietor millions4 ,m ?an "o p]son a few days aft] tak+ ! treatm5t has be5 wrongly accus$ ( pa9t+40 ,%\ld any ( ,! ,j\rnal read]s decide to take ! #ajj mail-ord] c\rse 9 8,auto-,hemic ,!rapy0 he %\ld realize t ev5 aft] he has done s !re are c]ta9 re/rictions 9 ! practice ( ?is 8!rapy40 ,9 no case mu/ he adm9i/] 8a c\rse ( ,auto-,hemic ,treatm5t0 = 8less ?an #ajj1 paid 9 advance40 ,! only exceptions to ?is rule are 8cases ( absolute *>ity1 expectant mo!rs & to p]sons positively unable to pay t am\nt40 ,fur!rmore1 ,dr4 ,rog]s says t = ! reputation ( 8 me?od1 z well z = ! good ( all conc]n$1 8,i insi/ t ! entire fee be paid 9 advance & t ! c\rse ext5d ov] a p]iod ( "o ye> :e!r ! pati5t ne$s few or _m treatm5ts40 ,,doll>s ,,& ,,c5ts ,= ^? :o d n wi% to take ! mail-ord] c\rse1 ,rog]s (f]s to prep>e individual specim5s ( ! 8s]um0 f blood t is s5t to him by ! physician4 ,! co/ ( ?is 8s]um0 is #e4jj1 89 advance10 ( c\rse4 ,/ill emphasiz+ ! comm]cial side1 8,auto-,hemic ,!rapy0 is especially recomm5d$ to 8! g5]al practition] gr[+ old & ! physician :o is ambiti\s to build up a cr$itable & lucrative practice0 because 8! heal? ( f\r p out ( five 7old or "y1 :e!r !y consid] !mselves sick or well7 tak5 at r&om c be improv$ by ?is me?od ( treatm5t06 ,an ,ohio physician 0 said to h d\bl$ 8 #c1jjj practice 9 two ye>s aft] />t+ ! 8,auto-,hemic0 me?od4 ,a ,virg9ia physician is alleg$ to h 8increas$ 8 income #aj1jjj a ye>40 ,a ,p5nsylvania physician urg$ by ,rog]s to s5d #aej4jj = ! mail-ord] c\rse1 0 assur$ t ?is 8is m]ely a nom9al am\nt1 z mo/ ( ! doctors h be5 able to get ?is am\nt back ! fir/ mon?40 ,b en\gh4 ,! /ory1 7 x n = ! tragic elem5t t =ms ! backgr\nd1 w\ld be amus+4 ,b x is tragic6--7,f ,! ,j\rnal ,a4,m4,a41 ,feb4 #ad1 #aibj47 8,,autolys90 ,,adv]tis+ ,to ! ,editor3--,enclos$ is a little booklet ,i receiv$ today f ! ,goodhue ,publi%+ ,co41 ( ,new ,york1 exploit+ ! ,hor[itz-,beebe cure-all = canc]1 :i*1 7 x n = c]ta9 obvi\s s]i\s features1 w\ld make humor\s read+4 ,:at psy*ologic explanation c be made ( ! fact t !re are always suffici5t numb]s ( suck]s to make su* pseudosci5tific adv5tures pr(itable8 ,h4 ,c4 ,dodge1 ,m4,d41 /eamboat ,spr+s1 ,colo4 ,to ! ,editor3--,9 my pr(essional life ,i h be5 flood$ ) ! usual numb] ( insults to intellig5ce bo? by mail & by ! s(tspok5 detail man4 ,z a result1 ,i h no d\bt1 ( ! active propag&a = re=m c>ri$ on by ,! ,j\rnal1 ^! insults h lo/ a c]ta9 quality ( 8rawness0 & become mu* m clev]ly done4 ,"o ( ^! has j be5 p]petrat$ on ! pr(ession :i* w probably hold ! *ampion%ip p5nant = #aiaf1 al?\gh ,i admit t x is e>ly 9 ! ye> to beg9 prophecy4 ,a v mode/ly b\nd1 well pr9t$ volume comes to my desk ) ! complim5ts ( ! publi%]s4 ,at ! end ( ! volume is a gr\p ( highly e?ical adv]tisem5ts ( o!r books ( ! au?or4 ,s f>1 s good4 ,! la/ f\r pages1 h[ev]1 conta9 ! adv]tisem5t ( a =?com+ book on ! 8autolys90 treatm5t ( inop]able canc]4 ,p]haps we might =give ?is 7 x n = ! foll[+ p>agraph3 8,?is book tells h[ ! g5]al practition] 444 may take an active h& 9 fight+ ! malady4 ,! weapons he requires are an ord9>y hypod]mic syr+e & "s ampules ( ,autolys94 ,! syr+e he already possesses4 ,autolys9 he may secure1 if he is a legally qualifi$ practition]1 by writ+10 etc4 ,incid5tally1 ! book is adv]tis$ to ! ,intellig5t ,layman4 ,isn't x beautiful8 ,too bad ! lam5t$ ,f4 ,f4 ,f4 ) 8 mock turtles or ^? prom95t eug5i/s ( scopolam9-morph9 fame c\ld n take a lesson 9 adv]tis+4 ,x 0 n v long ago t we 7 invit$ to come ,ea/ & le>n h[ to use 8autolys910 or else pay ! r heavy fee = an import$ tutor4 ,n[ all we ne$ is a 8gun0 & "s ( ! 8dope40 ,all ?is is int]e/+ 9 view ( ! rec5t article on ! failure ( 8autolys90 9 m\se tumor4 ,x is a =egone conclusion t a lot ( 8autolys90 w be us$1 s canc] pati5ts1 :o h be5 told t !y h canc]1 w get bett] ?r\gh sugge/ion1 & a lot ( en?usia/ic reports w p\r 9 f m$ical bre?r5 :o h nev] /udi$ psy*ology4 ,!n ! ?+ w slump & we %all all be ready = ! next fad4 ,nev]!less1 ea* "o ( ^! ?+s furni%es u ) a text = ano!r s]mon on e?ics ( m$ical adv]tis+1 s ,i suppose !y d n live 9 va94 ,j4 ,w4 ,=ce1 ,m4,d41 ,b]keley1 ,calif4 ,assi/ant ,pr(essor ( ,epidemiology1 ,univ]sity ( ,cali=nia4 ,comm5t4--,) ea* ( ! =ego+ communications is a circul> lett] f ! ,goodhue ,company1 adv]tis+ ,dr4 ,h5ry ,smi? ,williams' book on 8,! ,autolys9 ,treatm5t ( ,canc]40 ,) ?is circul> is a booklet entitl$ 8,notes on ! ,treatm5t ( ,inop]able ,canc] ) ! ,new ,rem$y ,,autolys9 7,hor[itz-,beebe7 ,issu$ by ! ,autolys9 ,laboratory40 ,simil> circul> lett]s & pamphlets h be5 s5t to ,! ,j\rnal f v>i\s p>ts ( ! c\ntry4 ,! ,goodhue ,company1 publi%]s1 !re=e are app>5tly kill+ two birds ) "o /one--adv]tis+ ! book z well z 8,autolys940 ,! ,j\rnal has be5 in=m$ t ,h5ry ,smi? ,williams 9 "s ( 8 magaz9e articles uses ! p5 "n 8,/odd>d ,goodhue10 & t ,h5ry ,smi? ,williams is a "p own] ( ! ,goodhue ,publi%+ ,company4 ,articles on 8,autolys90 w be f\nd 9 ,! ,j\rnal1 ,nov4 #f1 #aiae1 pp4 #afda1 #afdg & #affb4 ,! article on 8,action ( #8,autolys9' on ,m\se ,tumors10 by ,dr4 ,francis ,c>t] ,wood1 appe>$ 9 ,! ,j\rnal1 ,jan4 #h1 #aiaf1 p4 #id4-- ,ed4--7,correspond5ce 9 ,! ,j\rnal ,a4,m4,a41 ,jan4 #bi1 #aiaf47 8,,basic ,,canc] ,,rese>*0 ,,& 8,,cosmopolitan ,,canc] ,,rese>* ,,society0 ,m$ical j\rnals1 & "s o!r te*nical publications1 h receiv$ rec5tly :at purport to be items ( news value s5t out by ! 8,m$ical ,news ,bureau10 #gg ,sev5? ,ave41 ,brooklyn1 ,new ,york4 ,! 8manag]0 ( ?is alleg$ bureau is giv5 z ,d4 ,e4 ,woolley4 ,^! 8news items0 are undat$ b are m>k$3 87,= imm$iate release70 ,"o ( ^! />ts ) ! /atem5t1 attribut$ to ,mme4 ,curie1 t canc] c be cur$ by radium & !n cont9ues3 8,canc] c be cur$ by ! use ( sel5ium & tellurium1 m pl5tiful & less co/ly elem5ts10 says ,f4 ,w4 ,humphreys ( ,brooklyn1 an ,am]ican born /ud5t ( *emi/ry & sci5ce :o has devot$ ye>s to ! /udy ( ! cause ( canc] & ! discov]y ( me?ods = relief4444 8,= ! purpose ( fur!r develop+ me?ods ( control & treatm5t ( disease by ! use ( sel5ium & tellurium discov]$ by a numb] ( local sci5ti/s1 *emi/s & physicians1 ! ,basic ,canc] ,rese>* has be5 organiz$ & an effici5t laboratory e/abli%$ at #hdg ,union ,/reet1 ,brooklyn44440 8,?r\gh ! education ( ! p & special in/ruction to physicians x is hop$ x may soon be possible to ga9 control ( & eradicate ! disease :i* n[ appe>s s great a m5ace4 ,mr4 ,f4 ,w4 ,humphrey1 "o ( ! organiz]s ( ! new in/itution1 e/imates t )9 t5 ye>s1 or p]haps less "t1 canc] w no long] be consid]$ a fatal disease40 ,evid5tly ! jok] "h is ! 8,basic ,canc] ,rese>*0 ( #hdg ,union ,/reet1 ,brooklyn6 ,newspap]s are approa*$ f a diff]5t angle4 ,!y receive free publicity matt] on /ation]y read+ 8,cosmopolitan ,canc] ,rese>* ,society0 7,d4 ,e4 ,woolley1 secret>y71 #hdg ,union ,/41 ,brooklyn1 ,n4 ,y4 ,) ?is matt] is a lett] f ,woolley address$ to ! editor ( ! pap] to :i* ! /uff is s5t & ask+3 8,9 ! int]e/ ( suff]+ humanity w y please give space to ! enclos$8 8,no object ( great] importance has ev] be5 pres5t$ = y\r helpful consid]ation4 ,?\s&s are dy+ :om y c help save40 ,accord+ to ! 8news item0 t accompanies ?is lett] ! 8,cosmopolitan ,canc] ,rese>* ,society0 has be5 f\nd$ = ! purpose ( 8inve/igat+ & develop+ me?ods0 by :i* canc] 8may be successfully combat$ & ev5tually eradicat$40 ,x /ates fur!r t ! 8society0 w 8dissem9ate in=mation conc]n+ symptoms1 diagnosis1 treatm5t & me?ods ( prev5tion0 ( canc]4 ,fur!rmore1 ! memb]%ip ( ! society 8includes physicians1 sci5ti/s & *emi/s ( prom95ce1 laym5 ( means1 & ! sympa!tically incl9$ f all walks ( life40 ,nor is ?is all6 8,doctor ,fr$]ick ,kle9 ! em95t au?ority on ur9ology & ! *emi/ry ( canc]1 has evolv$ a new colorimetric te/ :i* is a mo/ wond]ful & valuable discov]y 9 ! diagnosis ( canc] & v>i\s o!r diseases4 ,?is te/ w be p>ticul>ly valuable 9 all life ext5sion "w because x det]m9es1 ev5 9 *ildr5 ! possibility ( pr$isposition t[>d any p>ticul> disease1 :e!r tub]culosis1 canc]1 diabetes or any ( ! diseases :i* 9 lat] life may become fatal4 ,x det]m9es also ! vitality ( ! subject enabl+ ! physician to accurately det]m9e ! condition ( any ( ! vital organs40 ,we le>n 9 clos+ t memb]%ips 9 ! 8society0 are 8graduat$ f #a4jj upw>ds accord+ to ! ability & disposition ( ^? :o may be int]e/$40 ,locat$ at #gg ,sev5? ,av5ue1 f :i* ! press ag5t mat]ial ( ! 8,m$ical ,news ,bureau0 is s5t1 is ! 8,basic ,*emical ,corporation ( ,am]ica40 ,accord+ to su* in=mation z we h be5 able to get1 ! presid5t ( ?is conc]n is ,f4 ,w4 ,humphreys1 ! 8/ud5t ( *emi/ry & sci5ce :o has devot$ ye>s to ! /udy ( ! cause ( canc] & ! discov]y ( me?ods ( relief40 ,we are in=m$ t ,mr4 ,humphreys 0 = a :ile 9 ! employ ( a 8*emical company0 ( ,philadelphia1 & has be5 9 ! photographic l9e d[n 9 ,virg9ia & lat] 0 connect$ ) a real e/ate conc]n 9 ,brooklyn4 ,ano!r (fic] ( ! ,basic ,*emical ,corporation is said to h be5 9 ! groc]y l9e 9 a small village 9 ,miss\ri1 sell+ out & lat] com+ to ,brooklyn & ent]+ ! insurance bus9ess4 ,/ill ano!r (fic]1 x seems1 0 9 ! fi% bus9ess4 ,9 addition to ^! ?ree (fic]s1 !re are two directors1 "o ( :om is 9 ! fancy groc]y l9e1 & ! o!r is a local practic+ physician ^: "n we f9d 9 ! ,propag&a dep>tm5t's te/imonial file "u ,sanmetto & ,ars5auro4 ,! ,dr4 ,fr$]ick ,kle91 :o is describ$ z ! 8em95t au?ority on ur9ology & ! *emi/ry ( canc]10 is n a physician b claims a ,ph4,d4 f ,muni*1 ,bav>ia4 ,kle9 claims to h develop$ c]ta9 ur9>y te/s4 ,"o ( ^!1 accord+ to him1 8indicates ! body ,vitality ) great accuracy10 ano!r proves ! pres5ce ( canc]1 a ?ird is ! 8syphilis te/0 & a f\r? is ! 8pregnancy te/40 ,& ^! are n all6 ,^? :o read ! reports ( ! ,c\ncil on ,ph>macy & ,*emi/ry may rememb] t ,fr$]ick ,kle9 is ! g5tleman :o made 8,sulfo-,sel5e10 :i* ! ,c\ncil1 9 refus+ x recognition1 describ$ z a 8mixture conta9+ a sel5ium comp\nd ( undet]m9$ composition produc$ by r$uction ( nitro-sel5\s acid ) sulphur\s acid1 mix$ ) bile salts & dilu5ts40 ,sulfo-,sel5e 0 widely exploit$ 9 ! newspap]s 9 #aiaf z a rem$y = canc]1 & ,kle9 got a good deal ( publicity at t "t4 ,j :at product ! ,basic ,*emical ,corporation ( ,am]ica is putt+1 or is ab\t to put1 on ! m>ket we d n "k4 ,f ! r vague talk ab\t sel5ium & ,fr$]ick ,kle9's m>vel\s diagno/ic discov]ies1 x might be inf]r$ t 8,sulfo-,sel5e0 0 to be resurrect$4 ,be t z x may1 x seems fairly obvi\s t ! mat]ial be+ s5t out by ,d4 ,e4 ,woolley--:e!r z 8,manag]0 ( ! 8,m$ical ,news ,bureau0 or z 8,secret>y0 ( ! 8,cosmopolitan ,canc] ,rese>* ,society0--is adv]tis+ matt] 9 ! guise ( news4 ,9 ?is connection x is wor? not+ t ! ,am]ican ,newspap] ,publi%]s' ,association1 9 a special bullet9 issu$ 9 #aiji1 publi%$ a v complete li/ ( press ag5ts & ! int]e/s ^! ag5ts repres5t$4 ,?is li/ conta9s ! "n ,d4 ,e4 ,woolley1 :o !n 0 s5d+ out press notices = ! ,national ,association ( ,piano ,deal]s ( ,am]ica4 ,is ?is ! g5tleman :o is n[ act+ z press ag5t = ! ,basic ,*emical ,corporation ( ,am]ica8 ,if x is1 x may be t ! slump 9 ! piano trade has caus$ ,mr4 ,woolley to turn f musical in/rum5ts to canc] cures4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,sept4 #c1 #aiba47 ,sel5i-,bascca ,9 ! issue ( ,septemb] #c ,! ,j\rnal call$ att5tion to a campaign ( free publicity t 0 be+ in/itut$ by a ,brooklyn conc]n t1 app>5tly1 _h = sale an alleg$ rem$y = canc]4 ,! press ag5t mat]ial 0 ( two k9ds--= m$ical j\rnals & = newspap]s4 ,t :i* w5t to ! m$ical j\rnals 0 s5t out on ! /ation]y ( ! 8,m$ical ,news ,bureau10 #gg ,sev5? ,ave41 ,brooklyn4 ,! 8manag]0 ( ! bureau 0 giv5 z ,d4 ,e4 ,woolley4 ,! items s5t out to m$ical j\rnals /at$ t ! 8,basic ,canc] ,rese>*0 _h be5 organiz$ to develop a treatm5t ( canc] by ! use ( sel5ium & tellurium4 ,! mat]ial receiv$ by newspap]s 0 s5t out by ! 8,cosmopolitan ,canc] ,rese>* ,society10 #hdg ,union ,/41 ,brooklyn 7! same address z ! 8,basic ,canc] ,rese>*074 ,! 8,secret>y0 ( ! 8,cosmopolitan ,canc] ,rese>*0 0 ,d4 ,e4 ,woolley6 ,! "n ( "o 8,dr4 ,fr$]ick ,kle90 loom$ l>ge 9 ! matt] s5t out by ! 8,cosmopolitan ,canc] ,rese>* ,society40 ,kle91 we 7 told1 is 8! em95t au?ority on ur9ology & ! *emi/ry ( canc]40 ,! ,j\rnal call$ att5tion to ! fact t ,fr$]ick ,kle9's "n 0 n unkn[n 9 ! ,propag&a files1 z he 0 ! g5tleman :o manufactur$ 8,sulfo-,sel5e10 a product t 0 widely h]ald$ 9 ! newspap]s 9 #aiaf z a rem$y = canc]4 ,x 0 also br\ght out t ,kle91 :o is n a physician1 claims to h evolv$ c]ta9 rem>kable ur9>y diagno/ic te/s :]eby ! pres5ce ( canc]1 syphilis1 etc41 may be det]m9$4 ,m ?an a mon? aft] ! publication ( ,! ,j\rnal's article1 a lett] 0 receiv$ 7,octob] #h7 f ,fr$]ick ,kle94 ,to quote lit]ally f "p ( ! lett]3 8,9 ! above ,j\rnal dat$ ,sept4 #c?1 ,vol4 #gg1 on page #hje1 reg>d+ ! #8,cosmopolitan ,canc] ,rese>* ,society' y h among/ o!rs1 m5tion$ my "n ,dr4 ,fr$]ick ,kle94 8,i wi% to in=m y t ,i h giv5 my legal advis] ! ord] to write a note to ! above ,cosmopolitan ,canc] ,rese>* ,society1 #hdg ,union ,/41 ,brooklyn1 =bidd5 !m to ! effect t my "n %\ld n be us$ by above society 9 any =m or writ+ 9 any ( _! transactions1 ?is has be5 done "s "t ago to prev5t une?ical conceptions conc]n+ myself40 ,%ortly aft] ! article ( ,septemb] #c ano!r item appe>$ 9 ! newspap]s ?r\gh\t ! c\ntry to ! effect t ! ,canc] ,rese>* ,society 0 (f]+ a 8#ajj1jjj ,canc] ,prize0 = a 8m$ic9al cure = canc]40 ,_m ( ! newspap]s ( ! c\ntry seem$ to bite on ?is piece ( free publicity4 ,?is 0 9 ! fir/ week ( ,octob]4 ,9 ! ?ird week ( ! same mon? a ,brooklyn pap] ann\nc$ t #c1jjj p _h submitt$ =mulas = cur+ canc] to ! ,cosmopolitan ,canc] ,rese>* ,society4 ,! article conta9+ ?is ann\ncem5t gave int]e/+ descriptions ( "s ( ! 8cures0 submitt$ & clos$ ) ! /atem5t t ! ,cosmopolitan ,canc] ,rese>* ,society 0 e/abli%+ 8cl9ics0 9 v>i\s cities4 ,x end$ ) ! /atem5t3 8,all treatm5ts are confid5tial4 ,9 ?is respect ! society _h ! coop]ation ( ! ,brooklyn ,bureau ( ,*>ities4 ,x also has ! coop]ation ( ! ,am]ican ,m$ical ,association40 ,! clos+ s5t5ce is1 ( c\rse1 unequivocally false4 ,at ! "t ( ,! ,j\rnal's article ! "n ( ! p>ticul> prep>ation :i* ! ,basic ,*emical ,corporation ( ,am]ica 0 putt+ out 0 unkn[n4 ,%ortly aft] ! article appe>$ x 0 le>n$ t ! product 0 on ! m>ket z 8,sel5i-,bascca40 ,a physician1 himself a suff]] f c>c9oma1 aft] read+ ! article ( ,septemb] #c1 s5t ,! ,j\rnal "s correspond5ce he _h receiv$ f ! ,cosmopolitan ,canc] ,rese>* ,society reg>d+ ! alleg$ cure4 ,"o piece 0 a lett] sign$ 8,f4 ,w4 ,humphrey1 ,act+ ,director2 ,dictat$ by ,dr4 ,george ,d4 ,b>ney10 :i* read 9 "p3 8,our claim is a v simple "o inde$1 namely t ! use ( a prop] prep>ation ( ,sel5ium 7,sel5i-,bascca7 re/ores ! ,sulphur metabolism to normal2 we claim t canc] _c exi/ 9 any =m1 :5 ! ,sulphur metabolism is normal1 ! results f ! prop] use ( ,sel5i-,bascca 9 cases ( ,c>c9oma are quick & la/+1 ! ,m$ical ,pr(ession c h>dly realize t 9 ?is mode/ treatm5t a rem$y = ! ,dread$ ,c>c9oma has be5 discov]$4 8,sel5i-,bascca 9 its colloidal =m is quickly tak5 up by ! blood /ream1 rea*es ! f9e/ tissues & almo/ imm$iately resi/s ! fur!r gr[? ( ! disease4 ,! rese>* "w has be5 go+ on s9ce #aija1 "u ! direction ( ,dr4 ,fr$]ick ,kle91 9 connection ) ,m$ical ,m5 :o h prov$ to _! own satisfaction t ,sel5i-,bascca %\ld be us$ z a treatm5t 9 e case ( malignancy40 ,sel5i-,bascca comes 9 small vials conta9+ fifty tablets4 ,ea* vial be>s a label read+3 8,,sel5ibascca4 ,a mixture ( ,colloidal ,sel5ium 9 tablet =m4 ,recomm5d$ 9 ! int]nal treatm5t ( ,c>c9oma & "s o!r cases ( faulty metabolism40 ,"s ( ! prep>ation 0 turn$ ov] to ! ,a4 ,m4 ,a4 ,*emical ,laboratory ) ! reque/ t ! tablets be exam9$ to det]m9e :e!r or n !y conta9$1 z claim$1 sel5ium 9 colloidal =m4 ,! laboratory report foll[s3 ,,*emical ,,report 8,an orig9al vial ( #8,sel5i-,bascca' 7,basic ,*emical ,corporation ( ,am]ica7 0 exam9$ 9 ! ,a4 ,m4 ,a4 ,*emical ,laboratory to det]m9e :e!r or n ! sub/ance conta9$ colloidal sel5ium4 ,! bottle conta9$ #ej tablets weigh+ approximately #j4a gm4 7ab\t #a-a_/b gr47 ea*4 ,! major portion ( ! tablet 0 soluble 9 hot wat]4 ,qualitative te/s indicat$ ! pres5ce ( *lorid1 sulphate1 small am\nt ( nitrate1 potassium1 sodium1 />*1 talc & sel5ium4 ,tellurium 0 n f\nd to be pres5t4 ,! a% 0 equival5t to #e4e p] c5t42 ov] "o-half ( ! a% consi/$ ( a talc-l sub/ance4 ,! am\nt ( sel5ium pres5t 9 ! specim5 exam9$ 0 only ab\t #a4c p] c5t4 8,9 ! lit]ature s5t out by ,! ,basic ,*emical ,corporation1 #8,dr4 ,fr$]ick ,kle9' is m5tion$ z *emi/4 ,sev]al ye>s ago1 ! ,c\ncil on ,ph>macy & ,*emi/ry inve/igat$ #8,sulfo-,sel5e1' a canc] rem$y1 ) :i* ! same #8,dr4 ,kle9' 0 connect$4 ,! alleg$ composition ( #8,sulfo-,sel5e1' z giv5 to ! ,c\ncil1 03 8,sel5ium 4#be 8,sulphur 7p>tially 9 colloidal 4#aj & p>tially 9 cry/alloid /ate7 8,potassium c>bonate 4#aj 8,nitrog5 4#je 8,bile ,salts 4#ej 8,to :i* is add$ an in]t base or vehicle2 z sug> ( milk or amylum40 8,x 0 claim$ t #8,sulfo-,sel5e' 0 prep>$ by r$uc+ nitro-sel5i\s acid ) sulphur\s acid1 neutraliz+ ) potassium bic>bonate & !n add+ bile salts4 ,assum+ t ! composition claim$ = #8,sulfo-,sel5e' 0 correct ! analysis ( #8,sel5i-,bascca' %[s t ! two products resemble ea* o!r4 ,! te/s1 h[ev]1 fail$ to reveal 9 #8,sel5i-,bascca' ! pres5ce ( ! bile salts claim$ to h be5 pres5t 9 #8,sulfo-,sel5e4'0 8,! product is n colloidal z claim$ z ! sel5ium c be remov$ by ord9>y filtration40--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #ai1 #aiba47 ,repudiat$ by ! ,brooklyn ,bureau ( ,*>ities ,to ! ,editor3--,my att5tion has be5 call$ to ! fact t !re appe>s 9 a rec5t issue ( ,! ,j\rnal ( ! ,am]ican ,m$ical ,association a /atem5t t ! ,cosmopolitan ,canc] ,rese>* ,society1 locat$ at #hdg ,union ,/reet1 ,brooklyn1 has ! coop]ation ( ! ,brooklyn ,bureau ( ,*>ities4 ,9 reply may ,i say t ! ,bureau ( ,*>ities has no connection1 und]/&+1 or relation%ip :atev]1 ) ! ,cosmopolitan ,canc] ,rese>* ,society1 & has nev] s5t a pati5t to !m4 ,t4 ,j4 ,riley1 ,brooklyn4 ,secret>y1 ,brooklyn ,bureau ( ,*>ities4--,correspond5ce f ,! ,j\rnal ,a4 ,m4 ,a41 ,dec4 #bd1 #aiba4 ,,bell-,,ans 7,,papayans1 ,,bell7,j ,z ! ,new ,york ,tribune's 8,ad-,visor0 ,sees ,x ,j ,see index = additional article on ,bell-,ans4 8,:y avoid draughts8 ,sit by an op5 w9d[ if y want to6 ,j take a few drops ( ,sneeze-o be=e y g into ! draught & aft] y come out ( x1 & y'll nev] cat* cold4 8,don't be afraid ( contagion4 ,kiss y\r ,uncle ,eb5ez]1 ev5 if he's dy+ ( tub]culosis6 ,j =tify y\rself ) a sip ( ,lungicide be=e y g to 8 b$side1 & ano!r :5 y come away1 & y'll be tak+ no risk4 8,are y go+ to sit !re & let ! o!r folks eat up all ! good ?+s j because y are afraid to pit* 91 :5 #b or #c ,bell-,ans tak5 be=e & aft] ! meal w\ld enable y to enjoy y\r %>e ( all t's com+ )\t a bit ( discom=t or di/ress8 ,bell-,ans has re/or$ ! pleasures ( ! table to ?\s&s :o say3 #8,i c n[ eat any?+ & pl5ty ( x1 too4'0 8,! fir/ two blurbs are ,! ,ad-,visor's4 ,! ?ird is a bona fide adv]tisem5t ( ,bell-,ans1 aim$ to cat* ! holiday trade4 ,!y are all patt]n$ aft] ! same /yle & ! fir/ two are no m lack+ 9 logic ?an ! la/4 ,ov]eat--delib]ately c\rt indige/ion--invite g\t--don't be a g\rmet1 be a g\rm&--be an anti-,hoov] & eat a lot ( food1 :e!r y ne$ x or n2 ?an take ,bell-,ans4 ,if x doesn't #8absolutely remove indige/ion1' y\r druggi/ w give y back y\r money6 ,c\ld any?+ be fair] ?an t8 8,su* copy z ?is is n limit$ 9 its evil effects to ! misguid$ individual :o eats lob/] & ice cream at midnight & tru/s to ,bell-,ans to atone = 8 indiscretion4 ,! mo/ s]i\s effect ( su* reckless advice is ! example :i* ! adv]tis+ sets to o!r adv]tis]s40 ,! comm5ts j quot$ are f ! ,ad-,visor dep>tm5t ( ! ,new ,york ,tribune ( ,feb4 #g1 #aiah4 ,!y are respectfully ref]r$ to ! ,new ,york ,m$ical ,j\rnal1 ! ,int]national ,j\rnal ( ,surg]y & ! ,woman's ,m$ical ,j\rnal--?ree presumably sci5tific publications t ?r\gh _! adv]tis+ pages urge physicians to prescribe ,bell-ans4--7,f ,! ,j\rnal ,a4,m4,a41 ,feb4 #bc1 #aiah47 ,,campho-,,ph5ique ,appeal+ to ! ,new ,fl$g$ ,graduate4 ,! secret>y ( ! ,h>v>d ,univ]sity ,m$ical ,s*ool receiv$ f ! ,campho-,ph5ique ,company ( ,/4 ,l\is a lett] t1 presumably1 has be5 s5t to mo/ ( ! m$ical colleges ( ! c\ntry4 ,x read3 8,we wi% to supply ! s5ior class ( all ,m$ical ,colleges ) physicians' samples ( ,,campho-,,ph5ique ,liquid & ,,campho-,,ph5ique ,p[d]1 & ,o9tm5t = #aiah4 8,we w ?ank y v k9dly if y w s5d u a communication /at+ ! numb] ( /ud5ts 9 y\r graduat+ class1 & if possible1 we w\ld l ! "n ( ea* & e /ud5t1 t we may s5d him p]sonally a sample ( ,,campho-,,ph5ique4 ,9 ?is way1 we are sure ! p>ty receives ! sample40 ,presumably1 ! ,campho-,ph5ique conc]n believes 9 foll[+ ! old advice3 ,cat* 'em "y6 ,9 ?is connection1 x may be well briefly to call to ! att5tion ( f\r?-ye> m$ical /ud5ts ! results ( ! inve/igation ( ! ,c\ncil on ,ph>macy & ,*emi/ry ( ,campho-,ph5ique4 ,! ,c\ncil's f9d+s on ,campho-,ph5ique ,liquid 7 to ! effect t ! prep>ation1 :i* 0 exploit$ "u a false 8=mula10 01 ess5tially1 a solution ( camphor & ph5ol 9 liquid petrolatum1 sub/ances well kn[n 9 m$ic9e & none ( :i* "u its own "n has be5 cr$it$ ) possess+ any sup]lative virtues4 ,! ,c\ncil's v]dict on ,campho-,ph5ique ,p[d] 0 t 8= all practical purposes x is ess5tially a camphorat$ talcum p[d]0 conta9+1 app>5tly1 suffici5t camphor & ph5ol to give ! talcum p[d] an odor4 ,x 0 fur!r br\ght out 9 ! ,c\ncil's report t ! ,campho-,ph5ique ,company 0 9 effect "o ( ! num]\s trade names adopt$ by "o ,james ,f4 ,ball>d ( ,/4 ,l\is4 ,mr4 ,ball>d seems to m>ket a numb] ( 8pat5t m$ic9es10 mo/ ( !m sold direct to ! public1 b "s1 z 9 ! case ( ,campho-,ph5ique1 exploit$ to ! public via ! m$ical pr(ession4 8,h]b9e10 a 8m>vel\s prep>ation0 t 8puts ! liv] 9 heal?y condition02 8,ball>d's ,sn[ ,l9im5t0 t :5 appli$ to w\nds p]=ms 8a p]fect cure t leaves no sc>02 8,dr4 ,t4 ,l4 ,/eph5s' ,*emical ,eye ,salve0 :i* 8acts quickly 9 all cases0 & cures 8fail+ vision10 are "s ( ! num]\s 8pat5t m$ic9es0 made & sold by ,ball>d4 8,coll9s ,ague ,rem$y10 8,swaim's ,panacea10 8,swayne's ,panacea0 & 8,r5ne's ,pa9 ,kill+ ,oil0 are f\r m ( ,mr4 ,ball>d's products1 = ea* ( :i* he has plead$ guilty 9 ! f$]al c\rts to mak+ false & fraudul5t claims kn[+ly & wantonly4 ,if m$ical colleges ( ! bett] class 7 turn+ out graduates today :o c\ld be caught by free samples ( su* no/rums z ,campho-,ph5ique1 !n1 inde$1 w\ld ! outlook = ! future ( sci5tific m$ic9e be a gloomy "o4 ,b !y are n4 ,! "y man or woman :o goes out today f a reputable m$ical college is imbu$ ) ! sci5tific _s1 has develop$ habits ( /raight ?9k+ & w n1 we believe1 be s uncritical z to accept at _! face value claims made = no/rums ( ! ,campho-,ph5ique type4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,feb4 #i1 #aiah47 8,,c9*oph503 ,,=m]ly 8,,atophan0 ,x w be rememb]$ t ! ,f$]al ,trade ,commission adopt$ ! names arsph5am9 & neo>sph5am9 = ! drugs fir/ introduc$ z 8salv>san0 & 8neosalv>san10 respectively2 ! t]ms b>bital & b>bital sodium = ! sub/ances fir/ introduc$ z 8v]onal0 & 8v]onal sodium10 & ! ^w proca9 z ! "n = ! comp\nd fir/ m>ket$ z 8novoca940 ,9 issu+ lic5ses = ! use ( ! pat5ts on ^! drugs1 ! commission /ipulat$ t ! drugs %\ld be sold "u ! new ,am]ican title unless ! firm desir$ to use a new trade designation1 9 :i* case ! titles *os5 by ! commission %\ld be giv5 equal prom95ce4 ,! ,c\ncil on ,ph>macy & ,*emi/ry has coop]at$ ) ! ,f$]al ,trade ,commission & has adopt$ ! new names z ! descriptive names :i* appe> 9 ,new & ,non(ficial ,rem$ies4 ,! ,*emical ,f\ndation1 ,inc41 :i* has pur*as$ "s #d1ejj ,g]man-own$ pat5ts1 _m ( !m = syn!tic drugs1 proposes to cont9ue ! wise policy ( ! ,f$]al ,trade ,commission by requir+ t ^? :o receive lic5ses = ! use ( pat5ts = syn!tic drugs mu/ use a common designation = ea* drug select$ by ! f\ndation4 8,c9*oph50 has be5 select$ z ! designation = ! sub/ance introduc$ z 8atophan0 7also describ$ 9 ! ,u4 ,s4 ,ph>macopeia "u 8ph5ylc9*on9ic acid074 ,9 consid]ation ( ?is action on ! "p ( ! ,*emical ,f\ndation1 & also because physicians f\nd x difficult to use ! ph>macopeia "n 8ph5ylc9*on9ic acid10 ! ,c\ncil on ,ph>macy & ,*emi/ry has recogniz$ ! contract$ t]m 8c9*oph50 z a "n = ! drug introduc$ z 8atophan40 ,x is hop$ t physicians w support ?is simplifi$ & nonpropriet>y nom5clature 9 ! same _s ) :i* !y adopt$ ! t]ms 8arsph5am910 8b>bital0 & 8proca940--7,editorial f ,! ,j\rnal ,a4,m4,a41 ,aug4 #i1 #aiai47 8,,collosols03 ,,an ,,uncritical ,,engli% ,,endorsem5t ,"u ! auspices ( ! ,briti% ,association = ! ,advancem5t ( ,sci5ce1 !re has j appe>$ a report on ! pres5t /atus ( colloid *emi/ry4#bdg ,! "w has be5 recogniz$ z suffici5tly important to receive ! endorsem5t ( ! gov]nm5t ,dep>tm5t ( ,sci5tific & ,indu/rial ,rese>*4 ,( p>ticul> int]e/ to physicians is ! *apt] on 8,adm9i/ration ( ,colloids 9 ,disease0 writt5 by ,alfr$ ,b4 ,se>le1 8consult+ *emi/1 ,%effield40 ,aft] a some:at academic g5]alization ( colloidal drugs1 ! 8!sis0 is devot$ l>gely to ! 8,collosols0--propriet>y prep>ations made by ! ,crookes ,laboratories4 ,! 8sci5tific0 evid5ce pres5t$ by ,se>le = colloids 9 m$ic9e reads z if ! adv]tis+ lit]ature ( ! ,crookes conc]n _h be5 consid]$ ample s\rce ( in=mation4 ,?us3 8,colloidal ,manganese10 besides hav+ be5 8us$ ) rem>kable & surpris+ results 9 ! treatm5t ( coccog5ic sk9 diseases1444 gives excell5t results 9 impetigo1 *ronic seborrheic eczema & acute folliculitis :5 employ$ 9 conjunction ) intram9e06 ,! grave dang] ( ! intram9e !rapy has be5 kn[n = m ?an two ye>s1 bo? "h & abroad1#bdh 9 fact1 "o au?or /at$ t 9 cases ( intram9e injections1 8! pa9 is undilut$ torture40 ,9 a /yle z bomba/ic & v]bose z ! usual h\se-organ write-up1 ! report recklessly details all sorts ( conditions 9 :i* s-call$ colloids--& p>ticul>ly ! 8,collosol0 br&--h be5 recomm5d$1 b d]ogatory f9d+s are conspicu\s by _! omission4 ,ev5 ,sir ,malcolm ,morris is quot$ z l5d+ 8 "n 7& title7 to ! endorsem5t ( 8,collosols40 #bdg ,briti% ,association = ! ,advancem5t ( ,sci5ce4 ,second ,report on ,colloid ,*emi/ry4 ,publi%$ = ! ,dep>tm5t ( ,sci5tific & ,indu/rial ,rese>* by ,8 ,maje/y's ,/ation]y ,(fice4 #bdh ,f]riv9e1 ,intram9e & ,collosol ,iod9e1 ,j4,a4,m4,a4 #fi3hda 7,sept4 #h7 #aiag4 ,9 ! ,unit$ ,/ates ! m$ical pr(ession has creat$ a means :]eby physicians ne$ n be misl$ by su* 8high0 au?orities z evid5tly has be5 ! case ) our ,engli% confrres4 ,once m ! value ( ! ,c\ncil on ,ph>macy & ,*emi/ry is /rik+ly manife/$4 ,:at are ! facts ab\t 8,collosols08 ,! ,c\ncil has report$ t a numb] ( ! 8,collosol0 prep>ations 7 n colloids at all1 & 8if 444 inject$ intrav5\sly z direct$1 dea? might result1 mak+ ! physician morally if n legally liable02#bdi t 9 ! cases 9 :i* ! !rapeutic claims 7 exam9$1 ! claims 7 f\nd to be ei!r exce$+ly improbable or exagg]at$2 fur!rmore1 t ! ,a4 ,m4 ,a4 ,*emical ,laboratory f\nd 8,collosol ,coca9e10 on analysis1 to conta9 only #dj p] c5t4 ( ! claim$ am\nt ( coca94#bej #bdi ,collosol ,prep>ations1 ,j4,a4,m4,a4 #gb3afid 7,june #g7 #aiai4 #bej ,collosol ,coca9e ,n ,admitt$ to ,n4 ,n4 ,r41 ,j4 ,a4 ,m4 ,a4 #gb3 #ajid 7,april #ab7 #aiai4 ,su* are ! f9d+s :i* h be5 pres5t$ to ! ,am]ican physician4 ,b ! ,briti% physician is n[ be+ made ! object ( an int5sive adv]tis+ campaign = 8,collosols10 bas$ 9 "p on an uncritical1 pseudogov]nm5tal endorsem5t4 ,j s long z ! ,engli% pr(ession w n protect itself by creat+ a compet5t bo>d to exam9e & judge propriet>y m$ic9es & to control me?ods ( exploitation1 j s long w su* extravagant & ev5 cruelly mislead+ claims cont9ue to imp$e sci5tific progress 9 !rapeutics4--7,editorial f ,! ,j\rnal ,a4 ,m4 ,a41 ,oct4 #ah1 #aiai47 ,collosol ,manganese ,to ! ,editor3--,has any?+ be5 publi%$ on ! efficacy ( 8,collosol ,manganese0 9 mal>ia8 ,i rec5tly read ! ,c\ncil's report :i* indicat$ ! faki%ness ( ! 8,crooke's ,collosols10 b ,i also 0 told t ! ,w> ,(fice ( ,engl& _h reque/$ a /udy to be made ( colloidal manganese 9 mal>ia4 ,j4 ,b41 ,columbus1 ,ohio4 ,,answ]4--,/eph5s1 ,yorke1 ,blacklock1 ,macfie1 ,coop] & ,c>t] report 9 ! ,annals ( ,tropical ,m$ic9e & ,p>asitology 7,feb4 #bh1 #aiai1 p4 #cde7 ! results ( _! inve/igation = ! ,engli% gov]nm5t & conclude3 8,collosol ,manganese 9 ! doses us$ is ( no value 9 ! treatm5t ( simple t]tian mal>ia40--7,qu]y 9 ,! ,j\rnal ,a4 ,m4 ,a41 ,may #c1 #aiai47 ,,cotton ,,process ,,e!r ,to ! ,editor3--,please let me "k :at in=mation y h ab\t ! enclos$ clipp+8 ,e4 ,w4 ,c>p5t]1 ,m4,d41 ,gre5ville1 ,s4 ,c4 ,to ! ,editor3--8,cotton ,process ,e!r10 manufactur$ by ! ,du ,pont ,co41 has be5 giv5 consid]able notoriety 9 ! lay press4 ,a lett] ( inquiry address$ to ! firm elicits ! in=mation t 8,cotton ,process ,e!r is a v highly ref9$ ,di-e?yl ,e!r *>g$ ) ,e?yl5e ,gas40 444 ,:at is y\r op9ion ( ! 8,cotton ,process ,e!r08 ,has ! ,c\ncil on ,ph>macy & ,*emi/ry inve/igat$ ?is product8 ,john ,l4 ,atlee1 ,m4,d41 ,lanca/]1 ,pa4 ,to ! ,editor3--,i h be5 wait+ = "s ref]5ce to ! new ane/hetic ref]r$ to 9 ! enclos$ clipp+1 b if any has be5 made 9 ! m$ical press ,i h fail$ to notice x4 ,if !re is any?+ ( int]e/ 9 connection ) ?is item1 & x is n too mu* tr\ble1 ,i w ?ank y to put me 9 t\* ) ! situation4 ,holman ,taylor1 ,m4,d41 ,=t ,wor?1 ,tex4 ,,answ]4--,ab\t ,janu>y #bj1 ! 8,news ,s]vice0 ( ! 8,e4 ,i4 ,du ,pont ,de ,nem\rs & ,co41 ,inc410 circul>iz$ ! press ( ! c\ntry ) :at x 0 pleas$ to t]m a 8good #8fill]'02 ?is p>ticul> piece ( press ag5t "w dealt ) 8,! ,new ,du ,pont ,e!r40 ,to quote "o p>agraph f ! 8,news ,item03 ,! new ane/hetic1 :i* is a highly ref9$ di-e?yl e!r1 modifi$ by ! addition ( gases1 has ! foll[+ *>act]i/ics3 7#a7 ! prop]ty ( induc+ & ma9ta9+ ane/hesia ) practical fre$om f po/op]ative nausea1 & 7#b7 ! prop]ty ( induc+ & ma9ta9+ analgesia 7consci\s ins5sibility to pa97 z di/+ui%$ f ane/hesia 7ins5sibility to pa9 plus n>cosis74 ,! ,du ,pont ,e!r & ! claims made = x are seem+ly bas$ on ! "w ( "o man1 8,james ,h4 ,cotton1 ,m4,a41 ,m4,d41 ,toronto1 ,canada10 :o publi%$ an article on 8,cotton ,process ,e!r & ,e!r ,analgesia10 9 ! ,am]ican ,j\rnal ( ,surg]y = ,april1 #aiai4 ,h[ev]1 ,cotton did n give ! composition ( ! 8new0 e!r nor1 s f> z we are aw>e1 has 8 "w be5 corroborat$4 ,9 view ( ! inquiries receiv$1 ! ,secret>y ( ! ,c\ncil on ,ph>macy & ,*emi/ry ask$ ! ,du ,pont ,*emical ,works = ! composition ( ! new e!r4 ,f ! firm's reply we quote "o p>agraph3 8444 ,! proc$ures ( manufacture1 & ! exact composition ( our e!r1 we reg>d z confid5tial in=mation :i* we are entitl$ to reta9 unless a condition 7 to arise 9 :i* we 7 unable alone to satisfy ! dem& = ?is type ( e!r40 ,x has be5 recogniz$--& incorporat$ 9 ! 8,pr9ciples ( ,m$ical ,e?ics0--t ! use ( a !rapeutic ag5t ( unkn[n composition is unsci5tific & contr>y to ! be/ int]e/s ( ! m$ical pr(ession & ! public2 b x is _m times m s]i\s = a physician to employ a secret or semisecret sub/ance z an ane/hetic4 ,a physician us+ su* a semisecret sub/ance w\ld h little def5se if ! pati5t %\ld die4--7,qu]y 9 ,! ,j\rnal ,a4 ,m4 ,a41 ,feb4 #ba1 #aibj47 ,a ,note f ! ,manufactur]s ,9 ! ,qu]y & ,m9or ,notes dep>tm5t ( ,! ,j\rnal ( ,febru>y #ba1 "s inquiries f physicians relative to 8,cotton ,process ,e!r0 7 answ]$4 ,9 ref]r+ to ! composition ( ?is product x 0 /at$ t ! secret>y ( ! ,c\ncil on ,ph>macy & ,*emi/ry _h ask$ ! manufactur]s1 ! ,du ,pont ,*emical ,works1 = in=mation on ?is po9t & "o p>agraph f ! firm's reply 0 quot$4 ,ano!r p>agraph f ! same lett] 0 omitt$2 & to ?is omission ! manufactur]s took exception1 express+ ! op9ion t by x ,! ,j\rnal l$ its read]s to inf] t ! conc]n _h 8refus$ to furni% any in=mation :atev]0 reg>d+ ! composition ( ! e!r4 ,! foll[+ p>agraph1 italiciz$ z 9 ! orig9al lett]1 is ! "o 9 "q3 8,cotton ,process ,e!r conta9s no compon5ts :i* d n occur 9 o!r ane/hesia e!rs4 ,its peculi> prop]ties result f ! ?or\gh me?ods tak5 to exclude h>mful impurities1 su* z aldehydes1 p]oxides1 traces ( acids1 c>bon monoxide1 sulphur comp\nds1 etc41 & to include c>efully regulat$ quantities ( only su* ( ! usual compon5ts z we h f\nd to give di/9ctly b5eficial prop]ties to ! e!r4 ,we are will+ to /ate t 9 ?is class we consid] prop]ly prep>$ e?yl5e ( greate/ importance1 b we h n ann\nc$ :i* ( ! b5eficial compon5ts ( ane/hesia e!r we include 9 our e!r1 or ! am\nt ( su* compon5ts40 ,z ! quotation %[s1 ! p>agraph is in=mative 9 a negative r ?an 9 a positive way 9 t x /ates :at ,cotton ,process ,e!r is n r ?an :at x is4 ,s9ce t "t1 h[ev]1 ! manufactur]s h notifi$ ,! ,j\rnal t !y h def9itely decid$ to pres5t ,cotton ,process ,e!r to ! ,c\ncil on ,ph>macy & ,*emi/ry = consid]ation & t 9 prep>+ ! data requir$ by ! ,c\ncil w def9e ,cotton ,process ,e!r z foll[s3 8,an improv$ ane/hesia e!r consi/+ ( highly ref9$ die?yl oxid 7,c,h7,o1 plus approximately two volumes ( e?yl5e 7,c,h71 #a_/b volume ( c>bon dioxide 7,,co7 & #a p] c5t4 by weight ( e?yl alcohol40--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,may #bb1 #aibj47 ,,dionol 8,dionol0 is adv]tis$ to physicians by ! ,dionol ,company ( ,detroit4 ,if "o takes ! ^w ( ! manufactur]s1 ! !rapeutic possibilities ( ,dionol are app>5tly limit$ only by ! blue sky4 ,ev5 ! company admits t 8! unprec$5t$ range ( action0 ( ?is m>vel 8may come z a surprise40 ,a glance ov] ! publi%$ 8case reports0 confirms ! inf]5ce4 ,f 8,b$ ,sores10 8,bubo10 8,cat>rh0 & 8,circumcision0 ?r\gh 8,cr\p10 8,deafness10 8,dysm5orrhea0 & 8,eczema10 includ+ 8,endometritis10 8,erysipelas10 8,ga/ritis0 & 8,hemorrhoids10 n omitt+ 8,o/eomyelitis10 8,otitis ,m$ia10 8,pneumonia0 & 8,ptoma9e ,poison+10 d[n ?r\gh ! pa?ologic alphabet to 8,qu9sy10 8,sciatica10 8,sp9al ,curvature10 8,v>icose ,ve9s10 & 8,:oop+ ,c\gh0 "o concludes t "h at la/ is a ca?olicon inde$4 ,:at is ,dionol8 ,fir/ x %\ld be said t ! prep>ation comes 9 two =ms3 z an o9tm5t & z an emulsion4 ,! o9tm5t1 s decl>e ! manufactur]s1 8is always requir$02 ! emulsion may be us$ 8z an auxili>y treatm5t40 ,! ,dionol 8lit]ature0 :5 /ripp$ ( ! v]bal cam\flage ) :i* x ab\nds may be said to prop\nd ! foll[+ !ories & propositions3 ,fir/1 t ! n]ves ( ! body are electric conductors insulat$ f ! surr\nd+ tissues by ! n]ve %ea?s2 second1 t inflammation breaks d[n ! insulation ) ! resultant escape ( ! curr5t & an int]f]5ce ) ! normal metabolic action ( ! cells2 ?ird1 t ,dionol1 :5 appli$ to ! body1 p5etrates ! tissues1 8coat+ ! cells & ) !m ! n]ve %ea?s ) a nonconduct+ lay] :i* is suffici5t to insulate ! n]ve %ea?s & /op ! leak40 ,s mu* = ! !ory on :i* ! alleg$ action ( ,dionol is bas$4 ,dionol itself is a sort ( glorifi$ petrolatum4 ,n1 ( c\rse1 t ! manufactur]s describe x 9 any su* crude & und]/&able language4 ,accord+ to ! company1 ,dionol is 8compos$ ( pure hydroc>bons1 especially select$ ) reg>d to specific gravity1 viscosity & o!r necess>y physical prop]ties0 :i* has be5 8p]fectly deioniz$ by our special sci5tific process "u ! ,ba9es ,me?od40 ,x appe>s1 f fur!r read+1 t ord9>y petrolatum w n 8turn ! trick02 presumably because x does n ov]come ! human %ort circuits :i* ! ,dionol ,company decl>e are always pres5t 9 inflammation4 ,:51 h[ev]1 ! petrolatum has be5 subject$ to ! 8,ba9es ,me?od0 x a*ieves1 x seems1 an esot]ic value t puts to %ame its plebeian orig94 ,! :ole ?+ is v simple4 ,to ^? physicians t l ?is sort ( ?+ ?is prep>ation %\ld make a /rong appeal4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #bf1 #aiah47 ,glorifi$ ,petrolatum ,an ,indiana physician s5ds u 9 a bat* ( leaflets detail+ ! m>vels ( 8,dionol0 & ?us comm5ts3 8,i receiv$ ! enclos$ 9 ! mail today & ,i am puzzl$1 p]plex$ & a/\nd$4 ,i _h =m$ ! op9ion t ! pr(ession 0 gett+ bett]2 t x 0 m s*ol>ly ?an =m]ly :5 ! two c\rse s*ool 0 /ill 9 exi/5ce & any "o c\ld matriculate2 t x 0 no long] possible = a #8pat5t m$ic9e' manufactur] to palm (f 8 w>es on u4 ,aft] read+ ?is /uff & realiz+ t su* me?ods mu/ be remun]ative1 ,i am deeply humiliat$4 ,is x possible t educat$ physicians respond to ?is k9d ( adv]tis+8 ,or has "s "o p]petrat$ a joke on me8 ,if ! pr(ession c be ?us successfully exploit$ "o c no long] wond] at ! foll[+ :i* e new #8ic' & #8ism' acquires40 ,x is a pity t ! m$ical pr(ession g5]ally does n react to ! ,dionol & simil> adv]tis+ z does our correspond5t4 ,z ! conc]n cont9ues to d bus9ess1 ! presumption is t at lea/ "s physicians are us+ ,dionol4 ,z 0 po9t$ out 9 ,! ,j\rnal ( ,jan4 #bf1 #aiah1 ,dionol seems to be a glorifi$ & esot]ic =m ( petrolatum4 ,! exploitation ( ,dionol is bas$ on ! foll[+ !ory3 7#a7 ,! bra9 is a g5]ator ( neuro-electricity2 7#b7 ! n]ves are ! conductors ( ?is electricity2 7#c7 ! n]ve %ea?s are ! insulator2 7#d7 :]ev] !re is local inflammation ! n]ves are %ort circuit$1 due to a break+ d[n ( ! insulation resi/ance ( ! n]ve %ea?2 7#e7 ?is results 9 8an escape ( neuro-electricity20 7#f7 ,dionol coats ! n]ve %ea?s ) a nonconduct+ lay] & ?is re/ores ! insulation & 8/ops ! leak40 ,:e!r ?is +5i\s !ory 0 inv5t$ to l5d an air ( v]isimilitude to an o!rwise bald & unconv9c+ tale & give a 8reason = be+0 = ,dionol or :e!r ,dionol 0 fir/ inv5t$ & x became necess>y to evolve a !ory t w\ld give "s plausibility to ! claims made = ?is e!raliz$ petrolatum1 we are unable to say4 ,9 any case ! !ory & ! product are exploit$ toge!r4 ,among ! mat]ial s5t 9 by a correspond5t are "s 8,dionol ,case ,reports40 ,nei!r ! names nor ! addresses ( ! physicians mak+ ^! reports are giv51 b ! company /ates t !y may be _h 8on reque/40 ,"o special 8report0 is featur$ "u ! head+ 8,infect$ ,w\nd4 ,/rik+ ,results ,aft] ,unit$ ,/ates & ,fr5* ,gov]nm5t ,army ,surgeons ,fail$0 is sign$ 8,dr4 ,w40 ,x is dat$ ,july #ai1 #aiai4 ,a few mon?s ago ! ,dionol ,company 0 s5d+ out ?is same te/imonial ) ! full "n & address ( ! 8doctor0 giv+ x4 ,inve/igation %[$ t ! 8doctor0 9 "q 0 an o/eopa? ^: specialties1 accord+ to 8 adv]tisem5t 9 8 local newspap]1 are 8,cat>rhal ,deafness & ,hay ,fev]1 ,acute & ,*ronic ,diseases06 ,9 ?is connection x is wor? not+ t inve/igation ( "s ( ! e>li] te/imonials s5t out by ! ,dionol conc]n & alleg$ to h be5 giv5 by 8doctors0 %[$ t ! g5tlem5 9 "q 7 8drugless heal]s40 ,z a 8true indication ( ! value :i* ! m$ical pr(ession is plac+ on ,dionol0 ! ,dionol ,company has publi%$ ! names ( "s physicians :o1 x is alleg$1 h us$ ! prep>ation4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,feb4 #g1 #aibj47 ,,! ,,eli ,,products ,,( ,,eli ,h4 ,,dunn ,physicians are receiv+ "s miscellane\s adv]tis+ matt] f a conc]n t seems to op]ate "u v>i\s names su* z 8,e4 ,h4 ,dunn ,co410 8,eli ,h4 ,dunn10 8,eli ,laboratory10 etc4 ,! conc]n is locat$ at #chbj ,ma9 ,/41 ,kansas ,city1 ,mo4 ,"o ,j\rnal read]1 :o is evid5tly n greatly impress$ by ?is mat]ial1 =w>ds ! /uff to u ) ! laconic reque/3 8,w y please give me y\r op9ion on ?is junk80 ,! 8junk0 ref]r$ to compris$1 9 "p1 an adv]tis+ leaflet on 8,eli #fjf ,capsules10 ano!r leaflet on 8,eli ,vag9al ,capsules10 /ill ano!r on 8,eli #8,vim' ,re/orative20 !n !re 0 ref]5ce to ! inevitable no/rum = intrav5\s use3 8,amp\les ,eli ,v5hydr>s540 ,a f\r-page leaflet1 head$ 9 l>ge & v black lett]s 8,confid5tial ,guide to ,live ,wire ,physicians ,only10 express$ its key-note 9 ! op5+ p>agraph3 8,h[ to make ,,money z well z ,,reputation 9 ! treatm5t ( all ,,*ronic ,,ailm5ts & all types1 =ms & sequella ( ,,v5]eal diseases40 ,! 8,eli #8,vim' ,re/orative0 is said to be a 8tonic aphrodisiac40 ,! 8action0 ( ! product is to 8,ar\se ,sexual ,ardor & ,desire4 ,influx blood supply to ! g5ital organs40 ,a po/script to ! 8,guide0 urges physicians3 8,if y d n already use ,intrav5\s ,s]ums1 by all means get an outfit1 if = no o!r reason ?an to meet ! popul> ,,dem&40 ,a 8,special ,note0 9 ! 8,confid5tial ,guide0 advises physicians :o 8h to deal ) ,hy/]ia0 to 8write ! ,au?or ( ?is ,guide1 :o w expla9 by p]sonal lett] a me?od ( coop]ation by :i* su* ,convulsions may be ,at ,once & =ev] /opp$4444 ,!re w be #ajj = ,y f e case treat$40 ,"o physician wrote to ! 8,au?or ( ?is ,guide0--,eli ,h4 ,dunn1 ,m4,d4--ask+ = fur!r in=mation on ?is treatm5t = hy/]ia4 ,he receiv$ 9 reply two lett]s bo? sign$ ,eli ,h4 ,dunn2 "o 0 to be %[n to ! pati5t1 ! o!r 0 = ! doctor's own in=mation4 ,! lett] = ! pati5t to see describ$ ! m>vel\s effects ( 8,dunn's ,intrav5\s & ,re/orative ,treatm5t0 9 hy/]ia & recomm5d$ x 8) ! utmo/ confid5ce 9 e case able to pay y ! fee comm5surate ) ! s]vice y r5d]40 ,!n foll[$ ^! two p>agraphs3 8,! co/ ( ! treatm5t :5 adm9i/]$ by y\rself is #cjj ,,ca% ,,) ,,ord]s :i* includes "o complete outfit & te*nique = adm9i/]+4 8,%\ld y call me p]sonally 9 consultation an additional fee ( #aej p] diem cov]+ ! "t ,i am away f my ,kansas ,city (fice2 fees to be collect$ & held until ,i arrive40 ,! lett] t 0 int5d$ only = ! doctor's eye decl>$3 8,y are to h #ajj ( ! fee & #ej ( ! p] diem40 ,x expla9$ t ! 8complete outfit0 ref]r$ to 9 ! 8pati5t's lett]0 w\ld 8consi/ 9 "p ( a tube ( intrav5\s m$ication0 & doses ( 8,re/orative ,capsules0 & 8,eli #fjf ,capsules40 ,eli ,h4 ,dunn seems to h _h a some:at v>i$ & spectacul> c>e]4 ,aft] be+ graduat$ 9 #ahhe he app>5tly />t$ practice 9 ,orion1 ,ill4 ,dur+ ! n9eties he 0 practic+ at ,elma1 ,i[a1 & ab\t #aijj he seems to h mov$ to ,kansas ,city1 ,mo4 ,dur+ #aijf & #aijh1 he also _h an additional (fice at ,d5v]1 ,col4 ,ab\t ?is "t he 0 exploit+ 8,dunn's ,ut]9e ,evacuant0 :i* 0 8a /rictly legitimate0 product :i* c\ld 8be inject$ )9 ! ut]us ) p]fect safety & imm$iate effect40 ,?is /uff 0 adv]tis$ bo? f ! ,kansas ,city & ! ,d5v] (fices4 ,! 8,p]sonal ,column0 ( a ,kansas ,city pap] 9 #aiaj c>ri$ ! message to 8,ladies0 t 8,dr4 ,dunn0 0 a 8,regul> physician = wom5 only10 ,dunn's violation ( ! po/al laws 9 #aiaa & ( ! f$]al ,food & ,drugs ,act 9 #aiab ne$ n be gone into at ?is "t4 ,! ,j\rnal w\ld feel l apologiz+ = devot+ space to su* a prepo/]\s s*eme 7 x n = ! fact t physicians1 be+ human1 sometimes 8fall =0 prepo/]\s s*emes4 ,"s1 we "k1 h nibbl$ at ,dunn's bait2 o!rs may d s4 ,! gross comm]cialism t p]meates ! adv]tis+ matt] s5t out by ,dunn aga9 emphasizes ! fact t ! fad = intrav5\s m$ication (f]s an attractive field = ^? :o w\ld exploit our pr(ession4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #bb1 #aiai47 ,,glov]',s ,,canc] ,,s]um ,scores ( lett]s h rea*$--& are rea*+--,! ,j\rnal (fice simil> 9 effect to ! foll[+3 8,i am enclos+ #8lit]ature' receiv$ f ! #8,t4 ,j4 ,glov] ,rese>* ,laboratory4' ,?\gh purport+ to come f ,toronto1 :]e ! #be4jj are to be s5t1 if y please1 ! envelope be>s ! #ddh ,new ,york po/m>k40 ,! above is f ,new ,j]sey :ile ! two foll[+ are f ,mi*igan & ,ill9ois1 respectively3 8,h y any in=mation 9 reg>d to ?is p>ty & 8 treatm5t = canc]8 ,?is is ! fir/ ,i h he>d ( any su* "w hav+ be5 done4 ,"o wond]s if x is pres5t$ 9 good fai? or if ! money god has ov]come ! g5tleman's sci5tific _s40 8,is ?is j "o m ( !m8 ,:y a roan horse8 ,"s p might want s]um f a nice bay or calico c[ pony40 ,! lit]ature ref]r$ to comes 9 an envelop be>+ ! "n ( 8,t4 ,j4 ,glov]1 ,rese>* ,laboratory1 ,toronto1 ,canada10 b mail$1 app>5tly1 f ,new ,york ,city4 ,! enclosures are a s+le %eet circul> sign$ ,?omas ,joseph ,glov] & entitl$ 8,etiology ( ,canc]10 a 8,directions0 slip & a c>d quot+ prices4 ,9 ! circul> ,dr4 ,glov] /ates t he has prep>$ a s]um f immuniz$ horses1 8betwe5 ages ( sev5 & n9e ye>s1 ( ! roan type10 & has inject$ ?is intramuscul>ly 8into pati5ts 9 ! advanc$ /ages ( canc] & notic$ t x has a specific action on e kn[n type ( canc]40 ,fur!r3 8,up to ! pres5t "t ,i h app>5tly cur$ canc] ( ! face1 eye1 nose1 lip1 m\?1 tongue1 /oma*1 b[el1 bladd]1 brea/ & ut]us40 ,9 addition to ! circul>1 0 a small leaflet giv+ directions = ! injection ( ! s]um & also a c>d be>+ ,dr4 ,glov]'s "n & ,toronto address & read+3 ---------------------------------------- -------------------- ,?is is to advise y t ,,dr4 ,t4 ,j4 ,,glov]',s ,s]um = ! treatm5t ( canc] c n[ be _h by application to (fice at above address4 ,,price ,,five ,,doll>s ,,p] ,,treatm5t4 ,,five ,,treatm5ts ,,m9imum ,,numb] ,,s5t ,,at ,,"o ,,"t4 ,s5d money by ,po/-,(fice ,money ,ord] or ,c]tifi$ ,*eque4 ,,directions ,,= ,,treatm5t ,,) ,,ea* ,,ord]4 ---------------------------------------- -------------------- ,?is adv]tis+ mat]ial1 :i* is evid5tly be+ widely circulat$ 9 ! ,unit$ ,/ates1 w\ld indicate t ! ,glov] ,rese>* ,laboratory _h receiv$ a p]mit f ! ,unit$ ,/ates ,public ,heal? ,s]vice lic5s+ ! int]/ate sale ( ?is s]um 9 ! ,unit$ ,/ates4 ,no su* lic5se has be5 issu$4 ,! ,j\rnal briefly report$ 9 ! dep>tm5t ( ,m$ical ,news1 ,oct4 #cj1 #aibj1 t ! ,academy ( ,m$ic9e ( ,toronto _h appo9t$ a committee to inve/igate ! claims made = ! ,glov] 8canc] s]um40 ,9 ! meantime1 ! mo/ *>itable ?+ t c be said is t ! 8treatm5t0 is 9 ! exp]im5tal /age & ! report$ results h n be5 corroborat$ by indep5d5t inve/igators4--7,f ,! ,j\rnal ,a4,m4,a41 ,jan4 #a1 #aiba47 ,! ,toronto ,academy ( ,m$ic9e ,reports ,unfavorably on ,glov]'s ,canc] ,s]um ,! me?od ( exploitation ( ! alleg$ canc] s]um be+ put out by ,dr4 ,t4 ,j4 ,glov] ( ,toronto1 ,canada1 0 briefly discuss$ 9 ?is dep>tm5t ( ,! ,j\rnal = ,janu>y #a4 ,at t "t x 0 po9t$ out t ! m$ical pr(ession ( ! ,unit$ ,/ates 0 be+ widely circul>iz$ by ,dr4 ,glov] & t1 :ile ! lett]s purport$ to come f ,toronto1 !y 71 9 fact1 mail$ f ,new ,york ,city4 ,s9ce ?is article appe>$ ! circul>ization seems to h cont9u$ undim9i%$ & physicians 9 v>i\s p>ts ( ! ,unit$ ,/ates h s5t 9 ! ,glov] adv]tis+ mat]ial4 ,oddly en\gh1 ! matt] n[ s5t out1 :ile id5tical 9 e respect ) t dealt ) 9 ! previ\s article1 be>s a diff]5t return address on ! back ( ! envelop4 ,! envelops are ! same2 b ! leg5d 8,t4 ,j4 ,glov] ,rese>* ,laboratory1 #ech ,j>vis ,/41 ,toronto1 ,canada10 has be5 crudely cross$ out & !re has be5 sub/itut$ by means ( a rubb] /amp ! leg5d 8,,mrs4 ,,/ew>t1 #cji ,w4 #ed? ,/41 ,new ,york40 ,/ill lat] lett]s h be5 modifi$ to ! ext5t t ! lett]s 8,,rs0 ( 8,,mrs40 h be5 cut out ( ! /amp & x n[ reads 8,m 4 ,,/ew>t40 ,!re has n[ come to h& a report j publi%$ by a special committee appo9t$ by ! c\ncil ( ! ,academy ( ,m$ic9e1 ,toronto1 to inve/igate ! ,glov] ,s]um4 ,! report ( ?is committee may be summ$ up by "o ( its clos+ p>agraphs1 :i* reads3 8,! data :i* y\r committee has be5 able to obta9 h n conv9c$ x t ! results ( treatm5t obta9$ by ! use ( ,dr4 ,glov]'s s]um are bett] ?an ^? obta9$ by simil> me?ods introduc$ by o!rs1 & :i* h ultimately disappo9t$ ! hopes ent]ta9$ ( !m40 ,! committee's report deals ) ! claims t ,dr4 ,glov] has made = 8 s]um1 bo? exp]im5tal & cl9ical4 ,x seems t ,dr4 ,glov] has claim$ t1 exp]im5tally1 he _h 7#a7 cultur$ canc] cells & f ^! cells _h isolat$ & cultur$ an organism :i* he decl>$ 0 conf9$ to1 & pres5t 91 e type ( canc]2 7#b7 produc$ canc] 9 a numb] ( animals by inoculation ) ^! cells & organisms2 7#c7 obta9$ a s]um--f a horse t _h be5 inject$ ) cultures ( ^! cells & organisms--:i*1 :5 inject$ into exp]im5tal animals r5d]$ !m immune to inoculation1 & 7#d7 produc$ improvem5t or cure 9 cases ( human canc] by ! injection ( 8 s]um4 ,! committee report$ t x 0 unable to obta9 any evid5ce to sub/antiate ,dr4 ,glov]'s claims on ! exp]im5tal aspect ( ! "q z ,dr4 ,glov] _h refus$ to p]mit repres5tatives ( ! committee to visit 8 laboratory2 _h refus$ ! reque/ ( ! committee to be all[$ to exam9e 8 cultures & exp]im5tal mat]ial2 _h n acc$$ to ! reque/ ( ! committee t he demon/rate 8 ability to culture canc] cells & organisms & to produce canc] by inoculation or to immunize animals aga9/ x4 ,! committee attempt$ also to collect in=mation :i* w\ld enable x to pass on ! cl9ical claims made by ,dr4 ,glov]1 fir/1 z to :e!r he has succe$$ 9 produc+ cures1 ei!r regul>ly or occasionally1 9 cases def9itely e/abli%$ z canc] &1 second1 to enable ! committee to decide :e!r 8 s]um 9 cases def9itely e/abli%$ z canc] produces improvem5t beyond t :i* occasionally occurs spontane\sly or "u palliative measures4 ,on bo? ( ^! po9ts1 ! committee report$ t x f\nd no evid5ce to w>rant ! hope t a specific cure = canc] has be5 discov]$ by ,dr4 ,glov] or t ! s]um _h produc$ a cure 9 any case def9itely e/abli%$ z canc]4 ,x %\ld be und]/ood1 t ! committee's inve/igations & f9d+s 7 complet$ be=e ! pres5t adv]tis+ campaign ( ! ,glov] s]um 0 initiat$4--7,f ,! ,j\rnal ,a4,m4,a1 ,feb4 #e1 #aiba47 ,,glyco-,,?ymol9e ,,& ,,poliomyelitis ,"o *>act]i/ic ( ! 8pat5t m$ic9e0 bus9ess is t x trades on fe>4 ,%\ld an epidemic occur ! m>ket is flood$ ) new no/rums purport+ to cure or prev5t ! disease 9 "q1 :ile ! manufactur]s ( old] 8pat5t m$ic9es0 revamp _! adv]tis+ s z to make x appe> t _! prep>ations are all t /& betwe5 ! sc\rge & ! public4 ,"o has b to rememb] 8,p]una's0 exploitation ( ! yell[ fev] epidemic 9 ,new ,orleans "s ye>s ago & ! way 9 :i* ! exploit]s ( 8,pond's ,extract0 play$ on ! fe>s ( ! public at ! "t ( ! =m] m5+itis epidemic 9 ,new ,york ,city4 ,at pres5t ! public is mu* ex]cis$ ov] ! epidemic ( infantile p>alysis4 ,anticipat+ t ! no/rum frat]nity w\ld attempt to reap a gold5 h>ve/ f ! public di/ress1 ! f$]al (ficials issu$ a bullet9 ( w>n+ on ! subject4 ,naturally1 ! bullet9 0 address$ to ! lay public1 ! gov]nm5t assum+ t physicians knew en\gh to avoid be+ misl$ by any su* adv]tis+ campaigns4 ,app>5tly1 ! assumption is too broad4 ,at any rate1 ! manufactur]s ( 8,glyco-,?ymol9e0 are circul>iz+ physicians1 "o ( :om writes z foll[s3 ,to ! ,editor3--,i am enclos+ circul> lett] t ,i receiv$ ?is morn+ :i* seems to me almo/ a crime4 ,i d n suppose t !re is any way to prev5t any?+ ( ?is sort1 b x is c]ta9ly a %ame to attempt to deceive p 9 ?is way4 ,z ,i recollect1 ,glyco-,?ymol9e is almo/ in]t1 practically no m effici5t ?an ,dobell's ,solution4 ,e4 ,flet*] ,+als1 ,m4,d41 ,*icago4 ,! circul> lett] ref]r$ to 0 on ! /ation]y ( ,kress ,ow5 ,company1 manufactur]s ( ,glyco-,?ymol9e4 ,x read3 ,de> ,doctor3--,reg>d+ ,infantile ,p>alysis1 x is conc$$ t ! s\rce ( infection is ?r\gh ! ,nose1 ,m\? & ,?roat4 ,tak+ ?is measure to be correct1 we believe t !re is no saf] prophylactic measure ?an ! use ( ,glyco-,?ymol9e1 ) ?ree p>ts ( wat]1 z a m\?1 too? & nasal wa%1 by means ( ! ,k4 ,o4 ,nasal ,d\*e & ! too?bru%4 ,glyco-,?ymol9e t5ds to promote exosmosis1 & prev5ts ! absorption ( ! g]m or toxic matt]4 ,we w\ld be glad to s5d y samples ( bo? ,glyco-,?ymol9e & ! ,d\*e %\ld y s desire4 ,) be/ wi%es1 we beg to rema91 ,y\rs v truly1 ,kress ,ow5 ,company4 ,glyco-,?ymol9e has be5 discuss$ 9 ^! pages4 ,a report ( ! ,c\ncil on ,ph>macy & ,*emi/ry po9t$ out t ?is 8pat5t m$ic9e0 is simply a weak antiseptic1 s feeble t ev5 9 full /r5g? x does n kill ,/aphylococcus aureus 9 f\r h\rs & is ( little1 if any1 great] !rapeutic value ?an /]ile salt solution4 ,yet1 ,glyco-,?ymol9e has be5 recomm5d$ by its manufactur]s1 ei!r directly or inf]5tially1 = su* diseases z diph!ria1 oph?almia neonatorum & consumption4 ,today its manufactur]s put x =w>d z "o ( ! safe/ prophylactic measures aga9/ infantile p>alysis & h ! effront]y to make ?is sugge/ion1 n to ! un9/ruct$ public b to ! m$ical pr(ession4 ,presumably1 z a bus9ess organization1 ! conc]n believes x w conv9ce a suffici5t numb] ( physicians ( ! !rapeutic efficacy ( its product to pay = ! co/ ( ?is adv]tis+ campaign4 ,if x appraises ! situation correctly !re ne$ no long] be any wond] express$ t 9 ! rec5t suit aga9/ ,! ,j\rnal1 8pat5t m$ic9e0 mak]s 7 able to enli/ ! help ( m$ical m54--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,sept4 #af1 #aiaf47 ,,glyk]on3 ,,cold ,,/orage ,,te/imonials,k ,k ,glyco-,h]o9 ,! law :i* limits ! l5g? ( "t t food products may be kept 9 cold /orage c\ld ) advantage h its scope ext5d$ to include 8pat5t m$ic9e0 te/imonials4 ,physicians rec5tly receiv$ ?r\gh ! mails--at a "t :5 ! mails 7 frightfully conge/$ ) ,*ri/mas bus9ess--a sixte5 page pamphlet s5t out 9 a pla9 envelop z fir/ class matt]4 ,! caption ( ! pamphlet reads3 8,c\gh & ,its ,treatm5t 9 ,pulmon>y & ,l>yngeal ,tub]culosis3 ,by ,h5ry ,levi51 ,m4,d41 ,:ile ,m$ical ,director & ,physician-9-,*>ge ( ! ,lib]ty ,sanit>ium1 ,lib]ty1 ,n4 ,y4 ,f ! ,buffalo ,m$ical ,j\rnal40 ,! pamphlet is devot$ to ! alleg$ virtues ( t dang]\s & widely adv]tis$ no/rum1 8,glyco-,h]o9 7,smi?710 ^: m rec5t & less descriptive "n is n[ 8,glyk]on40 ,physicians might assume1 & d\btless w assume1 f ! pamphlet t ?is repr9t repres5ts a rec5t pron\ncem5t on ! subject ) :i* x deals4 ,! facts are t ! 8,lib]ty ,sanit>ium0 has1 app>5tly1 be5 out ( exi/5ce = at lea/ fifte5 ye>s1 :ile ! article itself orig9ally appe>$ m ?an eighte5 ye>s ago--,septemb]1 #aija4 ,"o ( _m physicians :o s5t 9 ! copies receiv$ call$ att5tion to ! fact t he _h left ! address to :i* ! pamphlet 0 direct$1 m ?an six ye>s ago4 ,ev5 at t1 ! mail+ li/s ( ! conc]n t sells ?is h]o9-conta9+ no/rum are m ?an twelve ye>s ahead ( its 8cl9ical reports40--7,editorial f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #ag1 #aibj47 ,,gray',s ,,glyc]9e ,,tonic3 8,,^: ,,bread ,i ,,eat ,,8 ,,song ,i ,,s+0 ,la/ ,septemb] ! ,unit$ ,/ates ,dep>tm5t ( ,agriculture issu$ a press bullet9 describ+ ! "w ( ! ,bureau ( ,*emi/ry 9 prosecut+ ! v5d]s or manufactur]s ( fraudul5tly exploit$ 8pat5t m$ic9es40 ,at ! end ( ! bullet9 0 a tabulat$ li/ ( 8o!r prep>ations aga9/ :i* ! gov]nm5t's *>ge t !y 7 falsely or fraudul5tly label$ 0 su/a9$ by ! f$]al c\rts40 ,tuck$ away 9 ! li/ 0 a product (t5 euphemi/ically describ$ z an 8e?ical propriet>y0 b none ! less ess5tially a 8pat5t m$ic9e0--8,gray's ,glyc]9e ,tonic40 ,! editor ( ! ,atlanta ,j\rnal ( ,m$ic9e1 app>5tly n hav+ read ! bullet9 ) any great degree ( c>e1 publi%$ x v]batim4 ,?us x 0 t ! ,atlanta ,j\rnal-,record ( ,m$ic9e = ,septemb]1 #aiae1 pres5t$ ! int]e/+ sight ( a half-page adv]tisem5t ( 8,gray's ,glyc]9e ,tonic0 9 ! same issue t conta9$ ! gov]nm5t's article classify+ 8,gray's ,glyc]9e ,tonic0 among ! false & fraudul5t products6 ,:at happ5$8 ,9 ! v next issue ! ,atlanta ,j\rnal-,record ( ,m$ic9e apologiz$ ?us editorially3 8,9 our ,septemb] issue1 ,gray's ,glyc]9e ,tonic ,comp4 0 inadv]t5tly includ$ 9 a li/ t seem$ to be "u ! ban ( ! ,gov]nm5t & v likely an inju/ice has be5 done ! ,purdue ,fr$]ick ,company :i* we desire to undo z f> z possible40 ,did ! editor mean by 8inadv]t5tly includ$10 t he w\ld h omitt$ 8,gray's ,glyc]9e ,tonic0 f ! gov]nm5t's li/ _h he notic$ x 9 "t8 ,if s1 on :at gr\nds8 ,x is a fact t 8,gray's ,glyc]9e ,tonic0 0 "o ( ! 8,fifty ,falsely ,label$ ,m$ic9es02 x is also a fact t x is "o ( ! products t gov]nm5t (ficials & ! f$]al c\rts h decl>$ to be sold "u claims t are 8false1 fraudul5t & mislead+40 ,if 8,gray's ,glyc]9e ,tonic0 0 fraudul5tly exploit$--& ! gov]nm5t & ! c\rts h s decl>$ x--:y is x necess>y = ! editor ( a m$ical j\rnal to apologize to 8 subscrib]s = hav+ told !m s8--7,editorial f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #a1 #aiaf47 ,,hagee',s ,,cordial ,,( ,,cod ,,liv] ,,oil 8,"u ! deceptive head+ #8,mak+ ,cod ,liv] ,oil ,palatable1' ! ,*>lotte ,m$ical ,j\rnal 9 its ,decemb] issue pr9ts a boo/ = #8,cord4 ,ext4 ,ol4 ,morrhuae ,comp4 7,hagee71' or1 z x is g5]ally kn[n to ! drug trade1 #8,hagee's ,cordial ( ,cod ,liv] ,oil4' 8,! boo/ intimates t ?is is a prep>ation 9 :i* cod liv] oil has 9 "s way be5 r5d]$ palatable1 & !n goes on to say t ?is is a cod liv] oil product :i* has n suff]$ ! lea/ loss ( ^? ess5tial elem5ts :i* make ! crude oil su* a high-class recon/ructive4 8,at fir/ sight "o might "q :e!r a cod liv] oil product :i* conta9s absolutely no cod liv] oil _h n suff]$ ! loss ( ess5tial elem5ts4 ,b a clos] read+ discloses a significant qualification1 namely1 ! phrase1 #8^? elem5ts :i* make ! crude oil su* a high-class recon/ructive4' 8,! boo/ is mislead+ f beg9n+ to end4 ,! manufactur]s h n succe$$ 9 ?is prep>ation 9 #8mak+ cod liv] oil palatable1' nor does _! prep>ation 9 any way possess ! virtues ( cod liv] oil4 ,^! claims h aga9 & aga9 be5 refut$1 b !y cont9ue to be publi%$--at a price b r>ely 9 reputable m$ical j\rnals40 ,! above is quot$ f ! ,weekly ,bullet9 ( ! ,dep>tm5t ( ,heal? ( ! ,city ( ,new ,york4 ,! ,bullet9 is issu$ = ! enlight5m5t ( ! public4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #h1 #aiaf47 ,,hypno-,,bromic ,,comp\nd ,a physician 9 ,v]mont writes3 8,?is is simply a ^w ( inquiry--& ( possible w>n+ to o!r practition]s--reg>d+ a prep>ation kn[n z ,hypno-,bromic ,comp\nd manufactur$ by ,h4 ,k4 ,wampole ,co4 ,?is comp\nd is disp5s$ by druggi/s )\t prescription & conta9s 9 ea* ounce3 8,cannabis indica #a gr4 8,morph9 #a_/d gr4 8,potassium bromid #dh gr4 8,hyoscyamus #a gr4 8,*loral hydrate #if gr4 8,i h at ! pres5t "t ?ree "y wom5 :o are addicts to ?is prep>ation z ! result ( ?\ghtless prescriptions f physicians4 ,?is mixture evades ! work+ ( ! ,h>rison ,act & may be disp5s$ freely at ! discretion ( ! druggi/ &1 z a result1 ^! ?ree cases ( m9e h be5 able1 by visit+ at ! v>i\s drug /ores 9 t[n1 to keep an ample supply on h& at all times40 8,hypno-,bromic ,comp\nd0 is m ?an an unsci5tific mixture2 x is a dang]\s product & %\ld n be sold indiscrim9ately ov] ! drug c\nt]4 ,be=e ! ,h>rison ,n>cotic ,law w5t into effect1 8,hypno-,bromic ,comp\nd0 conta9$ half a gra9 ( morph9 sulphate to ! ounce in/ead ( its pres5t "o-f\r? gra94 ,physicians rememb] t ,section #f ( ! ,h>rison law conta9s a jok]--put ov] by ! 8pat5t m$ic9e0 int]e/s--t exempts propriet>y rem$ies conta9+ "o-f\r? gra9 ( morph9 or less to ! ounce f ! re/rictions ( t act4 ,:ile x is illegal = a physician to write a prescription :i* conta9s morph91 no matt] h[ small ! am\nt1 unless he con=ms 9 all ways to ! requirem5ts ( ! ,h>rison ,n>cotic ,law1 8pat5t m$ic9e0 conc]ns c sell indiscrim9ately no/rums conta9+ morph9 up to ?is am\nt & ! public c buy !m )\t let or h9drance4 ,no reputable druggi/ w\ld sell a layman ov] #gjj gra9s ( *loral hydrate or #b gra9s ( morph9 or #h gra9s ( extract ( cannabis indica1 )\t a prescription1 yet1 ! druggi/ may h& ov] #h ounce bottles ( ,hypno-,bromic ,comp\nd :i* conta9 #gfh gra9s ( *oral hydrate1 #b gra9s ( morph9 sulphate1 #h gra9s ( extract ( cannabis indica1 #h gra9s ( hyoscyamus & #chd gra9s ( potassium bromid6 ,physicians :o prescribe su* products z ,hypno-,bromic ,comp\nd & druggi/s :o indiscrim9ately sell su* /uff are disgrac+ two honorable pr(essions4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,feb4 #g1 #aibj47 ,,intrav5\s ,,comp\nd 7,,l(fl]7 ,its ,composition & ! ,peculi> ,me?ods by ,:i* ,x ,is ,exploit$ ,= "s "t pa/ inquiries h be5 receiv$ reg>d+ ,*>les ,lyman ,l(fl]1 8 ,po/-graduate ,c\rse 9 ,intrav5\s ,!rapy & especially relative to 8,intrav5\s ,comp\nd 7,l(fl]740 ,= in/ance1 a physician writes3 8,c y tell me any?+ ab\t ! ,physicians ,drug ,syndicate4444 ,!y are pu%+ ! sale ( ,?ymoz5e & (f]+ ,"o ,hundr$ ,doll>s' wor? ( /ock fully paid & non-assessable1 free to ^? s5d+ 9 _! ord]1 & also a copy ( ,dr4 ,l(fl]'s ,lectures on ! ,blood40 ,& f ano!r physician3 8,:at d y "k ( ,*>les ,l(fl]1 ,m4,d41 & 8 ,intrav5\s ,comp\nd8 ,a few ev5+s ago a man :o appe>$ to be ab\t #dj ye>s old came to my (fice & tri$ to int]e/ me 9 ! above-m5tion$ article2 he claim$ to be ,dr4 ,*>les ,l(fl] ( ,*icago4 ,) him 0 a "y lady :om he introduc$ z ,miss ,b----4 ,miss ,b---- said t %e _h be5 ) ,dr4 ,x---- a physician ( high /&+ 9 ,los ,angeles = two mon?s & t he 0 us+ ! ,intrav5\s ,comp\nd2 also quot$ o!r physicians4444 ,8 :ole lay\t looks quacki%1 & 7 x n = ! fact t he %[$ me a lett] t appe>$ to be f ,dr4 ,x----1 ,i %\ld n h giv5 him a second ?\ght40 ,& ?is also3 8,*>les ,l(fl]1 ,m4,d41 or 8 ag5t 0 travel+ ar\nd induc+ "o ,m4,d4 9 ea* t[n to take up 8 me?ods ( blood exam9ation & treatm5t & ) a little adv]tis+ ( blood exam9ations free ! doctor select$ gets q a run ( patronage40 ,ano!r physician writes3 8,my att5tion has be5 call$ by ano!r physician to ,l(fl]'s ,intra-,v5\s ,comp\nd4 ,may ,i tr\ble y to give me any in=mation t y may h ) reg>d to its composition & its value z a !rapeutic ag5t80 ,c4 ,l4 ,l(fl] does bus9ess f ,rooms #aaja-aajb1 ,v5etian ,bldg41 ,*icago1 ! location ( ! 8,intrav5\s ,*emical ,co410 ! 8,physicians ,drug ,syndicate0 & ! 8,ma-,oze ,*emical ,co40 ,( ^!1 m lat]4 ,! ,j\rnal has 9 its files a l>ge am\nt ( mat]ial reg>d+ ,l(fl]4 ,a brief rsum ( t "p ( ! mat]ial deal+ ) ,l(fl]'s pr(essional activities w be giv5 = ! purpose ( all[+ physicians to evaluate ! sci5tific /atus ( ,l(fl]'s 8,lectures10 8,po/-,graduate ,c\rses10 8 !rapeutic 8discov]ies0 & 8 products4 ,x seems t ,l(fl] 0 re>$ 9 ,yankton1 ,s4 ,d4 ,9 #ahih-ahii1 ,l(fl] 0 a s5ior /ud5t at ,john ,creighton ,m$ical ,college1 b1 = reasons t ne$ n be gone into "h1 he 0 nev] graduat$4 ,he receiv$ a diploma f ,b>nes ,m$ical ,college 9 #aijj1 & 9 ! same ye> 0 lic5s$ to practice 9 ,s\? ,dakota4 ,9 #aijb he 0 at ,le ,m>s1 ,i[a2 9 #aijd 8 "n appe>s 9 ! m$ical directory1 "u ,si\x ,falls1 ,s4 ,d41 z 8,speciali/ 9 ,*ronic ,tr\bles40 ,,! ,,intrav5\s ,,company ,,9 ,,colorado ,*>les ,l4 ,l(fl]'s 8specialty0 is 8,intrav5\s ,m$ication40 ,9 #aiab & #aiac1 z ! ,intrav5\s ,company ( ,colorado ,spr+s1 he 0 s5d+ out a booklet entitl$ 8,consumption40 ,?is describ$ ! alleg$ m>vel\s results to be obta9$ 9 ! treatm5t ( tub]culosis by ! use ( 8,intrav5\s ,comp\nd02 !re 0 also a side l9e1 8,! ,l(fl] ,int]nal ,ba? ,plate40 ,at t "t ! adm9i/ration ( 8,intrav5\s ,comp\nd0 0 recomm5d$ intrav5\sly1 hypod]mically1 by rectum1 by m\? & ev5 by insufflation4 ,:5 ! /uff 0 to be giv5 by rectum1 ! recomm5dation 0 made3 8,fir/ wa% out ! b[els ) a prelim9>y injection ( two or ?ree qu>ts ( w>m wat]1 us+ = ?is purpose ! ,l(fl] ,int]nal ,ba?40 ,9 #aiac ,l(fl] s\ght a l>g] field = 8 peculi> tal5ts & left ,colorado ,spr+s4 ,aft] a %ort /ay 9 ,d5v] he is next f\nd 9 ,m9neapolis1 :]e he 0 also 8engag$ 9 ! practice ( intrav5\s !rapy0 &1 incid5tally1 seems to h be5 an organiz] & manag] ( a common law conc]n kn[n z ! ,automatic ,?ra%] ,co4 ,,! ,,physicians' ,,drug ,,syndicate ,9 #aiai we f9d ,l(fl] 9 ,*icago z presid5t ( ! 8,physicians ,drug ,syndicate40 ,?is conc]n--ano!r common law organization--_h = its vice presid5t "o ,a4 ,e4 ,erl+1 ,m4,d41 & = its secret>y & treasur]1 ,ar?ur ,c4 ,hanson4 ,erl+ 0 discuss$#bea 9 an article t appe>$ 9 ,! ,j\rnal1 ,july #e1 #aiai1 on ! egregi\s 8,alli$ ,m$ical ,association ( ,am]ica0 ( :i* organization ,c4 ,l4 ,l(fl] 0 8,presid5t0 9 #aiah4 #bea ,"h is :at ,! ,j\rnal publi%$ on ,erl+3 ,a4 ,e4 ,erl+ accord+ to ! /ation]y1 is 8,*airman0 ( 8,c5sors40 ,our records fail to %[ t ,erl+ ev] graduat$ 9 m$ic9e4 ,! ,heal? ,dep>tm5t ( ,milwaukee1 h[ev]1 says t ,erl+1 :5 int]view$1 claim$ to h 8a diploma f ! ,g]man ,m$ical ,college ( ,*icago1 b refus$ to %[ or pres5t ! same40 ,! ,am]ican ,m$ical ,directory has ?is item3 ,g]man ,m$ical ,college1 ,*icago4 ,*>t]$ ,dec4 #bh1 #ahia1 by ,johann ,malok4 ,fraudul5t4 ,ext9ct4 ,a few ye>s ago ,erl+ 0 9 ,la ,crosse1 ,wis41 & 9 #aijh a circul> lett] be>+ 8 "n & picture 0 s5t out1 f :i* ! foll[+ extracts are tak54 ,capitalization z 9 ! orig9al3 8,de> ,fri5d3--,p]mit me to call y\r att5tion to ! fact t ,dr4 ,a4 ,e4 ,erl+1 ! em95t speciali/1 aft] _m ye>s ( travel1 practice & m$ical rese>*1 has giv5 up 8 ext5sive road practice & sev]$ 8 connection ) ! sev]al m$ical in/itutes :i* h h]et(ore occupi$ consid]able ( 8 att5tion4444 ,dr4 ,erl+'s success 9 ! treatm5t ( all ,,*ronic ,,diseases ,,is ,,truly ,,rem>kable4 ,,n]v\sness1 ,,all ,,blood ,,diseases1 ,,rheumatism1 ,,diseases ,,peculi> ,,to ,,wom52 ,,cat>rh1 ,,deafness1 ,,*ronic ,,con/ipation 444 ,,app5dicitis 444 ,,piles1 ,,/oma* ,,tr\bles1 ,,p>tial ,,p>alysis1 etc41 give way z if by magic "u 8 skilful me?od ( treatm5t4444 ,und]/&1 please1 t ,dr4 ,erl+ ,,does ,,n ,,accept ,a ,,case ,,= ,,treatm5t unless he c ,,promise ,a ,,spe$y ,,& ,,positively ,,p]man5t ,,cure40 ,! ,j\rnal also has 9 its files adv]tisem5ts 7v9tage ( #aiae71 f "s ,wiscons9 c\ntry newspap]s2 :i* notify ! afflict$ t 8,drs4 ,erl+ & ,k>ass1 ! exp]t ,g]man ,speciali/s10 c\ld be se5 9 _! (fices 9 ! 8,s*legel ,hotel10 ! 8,s*litz ,hotel10 etc41 z ! case might be4 ,:e!r "o ( ^! 8,g]man ,speciali/s0 0 ,dr4 ,arnold ,e4 ,erl+1 ,! ,j\rnal does n "k4 ,(ficial m$ical records fail to %[1 at lea/1 t !re is any o!r ,erl+ 9 ! /ate ( ,wiscons94 ,hanson1 ! secret>y & treasur] ( ! ,physicians ,drug ,syndicate1 is said to h hail$ orig9ally f ,m9ot1 ,n4 ,d41 :]e he 0 9 ! drug bus9ess4 ,8 "n appe>s 9 ! ,propag&a files z ! manag] ( ! ,ma-,oze ,*emical ,co4 ( ,m9neapolis1 :i*1 9 ,octob]1 #aiai1 0 adv]tis+ 9 a daily pap] ( t city3 8,protect y\rself aga9/ influ5za4 ,don't let ! g]ms get a foo?old 9 y\r sy/em4 ,kill !m ) ,ma-,oze ,antiseptic ,p[d]4 ,use x z a g>gle4 ,x is 444 sure dea? to all k9ds ( disease g]ms40 ,9 a prelim9>y /atem5t s5t out by ,hanson 9 ! e>ly "p ( #aiai x seems t ! ,physicians ,drug ,syndicate 0 conceiv$ 8prim>ily to supply physicians ) a product to be us$ 9 ,leucorrhea & p]sonal cleanl9ess ( wom540 ,?is product1 app>5tly1 0 ! ,ma-,oze ( influ5za fame 9 ,m9neapolis4 ,x 0 to be put out1 h[ev]1 "u ! "n ( 8,?ymoz5e10 :i*1 8pack$ 9 #d ounce unlabel$ c>ton = disp5s+10 w\ld 8%[ ne>ly #ajj p] c5t4 pr(it to ! organization ov] ! pr(it :i* y make if y disp5se y\r own drug40 ,,?ymoz5e1 ,,free ,,/ock--,,& ,,ev]y?+ ,9 ,octob]1 #aiai1 ! ,physicians ,drug ,syndicate 0 circul>iz+ physicians 9 ,i[a try+ to get !m to s5d 9 #f = 8#a ,doz5 ,?ymoz5e #d oz40 ,= ?is #f ! doctors 7 to get1 9 addition to ! m>vel\s ,?ymoz5e1 ! foll[+ rights1 privileges & emolum5ts3 #a4 ,a free ,po/-,graduate ,c\rse 9 ,intrav5\s ,!rapy by ,dr4 ,*>les ,l(fl]4 #b4 ,a gift ( #ajj wor? ( /ock 9 ! ,physicians ,drug ,syndicate4 #c4 ,a copy ( ,dr4 ,l(fl]'s ,lectures on ,blood4 #d4 ,! privilege ( pur*as+ future supplies ( ,?ymoz5e 8at :olesale prices less disc\nt ( #cc-a_/c p] c5t40 ,! lett] mak+ ^! (f]s m5tion$ incid5tally3 8,besides our product ,?ymoz5e we h be5 =c$ to add a ,ut]9e ,waf] to be us$ 9 connection ) hot ,?ymoz5e d\*es 9 ,leucorrhea4 ,^! waf]s are simply miracle work]s40 ,9 addition to ?is circul> lett] !re 0 a memb]%ip blank leaflet detail+ ! m>vels ( 8,?ymoz5e40 ,!re 0 ano!r leaflet head$ 9 v l>ge1 black type 8,influ5za0 & recomm5d+ 8,ma-,oze ,antiseptic ,p[d]0 or 8,?ymoz5e0 = ?is condition4 ,/ill ano!r leaflet accompany+ x laud$ 8,intrav5\s ,comp\nd 7,l(fl]70 & repr9t$ laudatory puffs ( ?is prep>ation t 7 cr$it$ to ,h4 ,h4 ,)]/9e1 ,m4,d41 ,ro*e/]1 ,m9n41 ,joseph ,b4 ,kl9ehans1 ,m4,d41 ,*icago1 & ! 8,lor+ ,p>k ,sanatorium0 ( ,m9neapolis4 ,9 addition to ! ,intrav5\s ,comp\nd 7,l(fl]7 !re is1 ( c\rse1 c]ta9 8app>atus = ! giv+ ( ! treatm5t0 :i* ! ,intrav5\s ,*emical ,co4 supplies4 ,! 8comp\nd0 mu/ be giv5 j s1 & ! ,intrav5\s ,*emical ,co4 8res]ves ! "r to refuse to supply any physician ) ,intrav5\s ,comp\nd 7,l(fl]7 :o1 ei!r ?r\gh lack ( prop] app>atus or prop] c>e 9 prep>ation ( solution1 or = any reason1 uses x 9 su* a mann] t w ca/ discr$it ^u x40 ,! complete app>atus1 includ+ #b ounces ( ,intrav5\s ,comp\nd 7,l(fl]71 sells = #bd4 ,:at is ,intrav5\s ,comp\nd8 ,app>5tly1 nobody kn[s except ,*>les ,l4 ,l(fl]1 :o asks physicians to inject--& we regret to say "s are inject+--?is no/rum ( unkn[n composition into ! ve9s ( _! pati5ts4 ,to a physician :o _h rais$ ! po9t ( secrecy ,l(fl] wrote 9 "p3 8,i am sure t y w agree ) me t x is f> bett] to place ?is treatm5t 9 ! h&s ( compet5t physicians1 su* z ,dr4 ,)]/9e1 & _m m ^: names ,i w gladly s5d y1 & to protect ! hone/ & compet5t doctor :o inve/igates & takes up ! "w1 ?an to publi% ! =mula & give to ! unscrupul\s a *ance to try to make ! product & no d\bt to claim to cure disease t is beyond hope4 ,! =mula is n kept secret = pr(it 444 b is s kept ^u ! advice ( a numb] ( good m5 :o h ! int]e/ ( ! doctor at he>t4444 ,i am will+ & anxi\s to place ! product & ! results 9 ?\s&s ( cases be=e ! ,a4 ,m4 ,a4 on ! "o condition t ! =mula %all be kept secret = ! b5efit ( ! reputable physician40 ,9 ano!r lett] writt5 m rec5tly to a physician :o call$ att5tion to ! secrecy ( ! no/rum1 ,l(fl] wrote3 8,! ,intrav5\s ,comp\nd conta9s approximately #eh p] c5t4 oxyg51 #ab p] c5t4 *lor9e1 #af p] c5t4 potassium1 #i p] c5t4 sodium & #e p] c5t4 boron4 ,i h no hesitancy 9 giv+ x1 & x 0 due to an incompet5t man 9 ?is (fice t ?is 0 n giv5 fully 9 ! booklet4 ,he made ! *anges )\t my cons5t & has caus$ me to answ] _m inquiries by physicians40 ,a seem+ frankness is a trick z old z no/rum exploitation itself4 ,l(fl]'s 8=mula0 is mean+less4 ,a quack :o 0 putt+ out a mixture ( #a "p bak+ soda & #b p>ts common salt might ) equal frankness say t 8 m>vel\s comb9ation conta9$ approximately #ce4d p] c5t4 sodium1 #d4h p] c5t4 c>bon1 #ai p] c5t4 oxyg51 #dj4d p] c5t4 *lor91 & #j4d p] c5t4 hydrog54 ,9 ord] t ! pr(ession might "k m ab\t ?is product a specim5 0 turn$ ov] to ! ,a4 ,m4 ,a4 ,*emical ,laboratory = analysis4 ,"h is :at ! *emi/s report3 ,,*emi/s' ,,report 8,"o orig9al #b ounce bottle ( #8,intrav5\s ,comp\nd 7,l(fl]7 = ,intrav5\s ,use' 0 submitt$ to ! ,association's ,*emical ,laboratory = exam9ation4 ,accord+ to ! label1 ! product is sold by ! #8,intrav5\s ,*emical ,co41 ,*icago4' ,! bottle conta9$ a :ite granul> sub/ance1 :i* appe>$ z if ! +r$i5ts _h be5 fus$ toge!r4 ,! product respond$ to te/s = sodium1 potassium1 *lorate1 borate & nitrate4 ,z ?is same set ( *emical radicals 0 f\nd by ,puckn] & ,hilp]t 7,j4 ,a4 ,m4 ,a41 ,may #bb1 #aijh1 p4 #agjf7 to be pres5t 9 #8,oxy*lor9' & #8,zyme-oid1' a quantitative comp>ison ( #8,intrav5\s ,comp\nd 7,l(fl]7' 0 made4 8,! analysis indicat$ t all ?ree products are ess5tially ! same3 ,,intrav5\s ,,oxy*lor91 ,,zyme-,,oid1 ,,comp\nd1 ,p] ,c5t4 ,p] ,c5t4 ,p] ,c5t4 ,potassium 7,k7 #ab4bf #ac4ej #ac4gi ,sodium 7,na7 #h4bj #i4hd #i4hb ,boric acid anhydride 7,b,o7 #ah4fc #ac4db #ae4bj ,*lorate 7,cl,o-7 #be4eb #bg4ec #bf4dd ,nitrate 7,,no-7 #ba4gj #bd4bb #bc4ge ,wat] calculat$ #ac4bi #aj4db #aa4gb 8,assum+ t ! *lorate 9 #8,intrav5\s ,comp\nd 7,l(fl]7' is pres5t z potassium *lorate & ! nitrate is pres5t z sodium nitrate1 ! figures obta9$ by ! analysis correspond to a mixture approximately z foll[s3 ,potassium *lorate 7,k,cl,o7 #ch4f p] c5t4 ,sodium nitrate 7,na,n,o7 #cb4f p] c5t4 ,potassium borate 7,k,b,o7 #d4i p] c5t4 ,sodium borate 7,na,b,o7 #d4j p] c5t4 ,boric acid #ba4a p] c5t4 8,f ! results ( ! exam9ation x is conclud$ t ?is prep>ation is a mixture ( alkali *lorate & nitrate & boric acid1 probably produc$ by fus+ toge!r ! con/itu5ts4 ,x is practically ! same mixture z ,oxy*lor9e & ,zyme-oid z analyz$ ne>ly f\rte5 ye>s ago 9 ! ,a4 ,m4 ,a4 ,*emical ,laboratory40 ,?r\gh\t ! adv]tis+ ( 8,intrav5\s ,comp\nd 7,l(fl]70 ! physician is rem9d$ ( ! f9ancial returns t ! product (f]s4 8444 ,! f9ancial return w prove z int]e/+ to y\rself z results are to ! pati5ts40 8,& la/ly b n less int]e/+1 ! f9ancial returns are comm5surate ) results40 8444 ! in/ruction giv5 me 9 ! use ( y\r ,intrav5\s ,comp\nd & ! opportunity pres5t$ adds f\r to five hundr$ doll>s p] mon? to my bank acc\nt40 8444 w n only give y m positive results ?an h ev] obta9$ 9 *ronic & progressive diseases b a v remun]ative bus9ess40 8,intrav5\s ,comp\nd 7,l(fl]7 is suppli$ 9 granul> =m1 #b ounces to a bottle1 at #b p] bottle4 ,an ounce w av]age fifte5 treatm5ts & treatm5ts are at f #c to #e ea*1 accord+ to ! ability ( ! pati5t to pay40 ,a physician ^: "n ! ,intrav5\s ,*emical ,company _h giv5 z a us] ( ,intrav5\s ,comp\nd 7,l(fl]7 0 writt5 to by ano!r physician :o 0 int]e/$ 9 ! matt] & he 0 ask$ frankly = 8 op9ion4 ,he repli$ 9 "p3 8,! treatm5t makes a pr(\nd impression on ! recipi5t & is usually foll[$ by a m>k$ improvem5t m5tally1 & ,i h n be5 ke5 en\gh to draw ! l9e ( j h[ f> ! physical or mat]ial improvem5t w5t & :5 ! psy*ical began4 8,= ! (fice #8speciali/' ( ! adv]tis+ type ?is w\ld be a boon1 b ,i am n entirely satisfi$ t its use completely ju/ifies its claims40 ,,summ>y ,intrav5\s ,comp\nd 7,l(fl]7 /&s reveal$ z a no/rum ( secret composition :i* physicians are ask$ to inject into ! ve9s ( _! pati5ts4 ,x mu/ be pur*as$ 9 connection ) "s supplem5t>y mat]ial1 8a complete set ( app>atus10 sold by ! same conc]n4 ,its successful adm9i/ration is said to dep5d on foll[+ a te*nic detail$ ei!r 9 a booklet s5t out by ,l(fl] or giv5 by ,l(fl] 9 a 8,po/-graduate ,c\rse0 :i* co/s physicians #ej unless !y h pur*as$ six doll>s' wor? ( ano!r no/rum1 8,?ymoz5e40 ,! intrav5\s adm9i/ration ( drugs is impressive4 ,to ! pati5t ! te*nic is my/]i\s & its psy*ic effect /rik+4 ,its dang]s--infection1 air embolism1 intravascul> clott+1 sudd5 dea?--are matt]s ( record4 ,e cons]vative physician w admit t !re is no excuse = ! intrav5\s adm9i/ration ( ev5 ^? drugs t are well kn[n & ^: effects h be5 c>efully /udi$1 except :5 di/9ct advantages are to be secur$4 ,z ,! ,j\rnal has /at$ be=e1 8,little is kn[n ( ! results to be expect$ f intrav5\s !rapy ev5 ) simple sub/ances40 ,:at1 !n1 c be said ( ! physician :o subjects 8 pati5ts to ! intrav5\s injection--8at f #c to #e ea*1 accord+ to ! ability ( ! pati5t to pay0--( a prep>ation ( ^: composition he is z ignorant z he mu/ be ( its effects8 ,intrav5\s ,comp\nd 7,l(fl]7 has be5 on ! m>ket t5 ye>s2 x is unm5tion$ 9 ! lit]ature ( sci5tific m$ic9e4 ,! "n ( its exploit]1 :ile n unkn[n 9 ! twilight zone ( pr(essionalism z ! exploit] ( a no/rum1 z a 8,speciali/0 9 8,*ronic ,tr\bles0 & 8,intrav5\s ,!rapy10 z well z 9 o!r capacities ev5 less savory1 is equally unkn[n to sci5tific m$ic9e4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #ab1 #aiba47 ,,intrav5\s ,,specialties ,to ! ,editor3--,!re is a salesman "h 9 ,salt ,lake ,city mak+ extravagant claims ab\t ! m$ic9es adv]tis$ 9 ! enclos$ pamphlet4 ,w\ld y k9dly advise me z to y\r op9ion ( x8 ,w4 ,c4 ,s*ulte1 ,m4,d41 ,salt ,lake ,city4 ,to ! ,editor3--,i am int]e/$ 9 kn[+ ! attitude ( ! ,c\ncil on ,ph>macy & ,*emi/ry reg>d+ ! products ( ! ,intrav5\s ,products ,company ( ,am]ica1 #aba ,madison ,av5ue1 ,new ,york ,city4 ,if ! ,c\ncil has already report$1 please ref] me to ! appropriate numb] ( ,! ,j\rnal4 ,if x has n1 please give me any in=mation available4 ,h4 ,b4 ,gessn]1 ,m4,d41 ,new ,orleans4 ,,answ]4--,! ,intrav5\s ,products ,company ( ,am]ica has n reque/$ ! ,c\ncil on ,ph>macy & ,*emi/ry to exam9e any ( its intrav5\s specialties1 nor h !y be5 discuss$ 9 ,! ,j\rnal or exam9$ 9 ! ,am]ican ,m$ical ,association ,*emical ,laboratory4 ,! firm's li/ ( specialties be>s a /rik+ resemblance to ^? ( o!r 8intrav5\s specialty0 firms4 ,endo>san1 l ,v5>s5 ( ! ,intrav5\s ,products ,company ( ,d5v]1 is /at$ to conta9 a cacodylate 7dime?yl>s5ate7 along ) m]cury & iodid4 ,v5>s5 0 report$ on unfavorably by ! ,c\ncil 7,! ,j\rnal1 ,may #bb1 #aiae1 p4 #aghj71 ! inf]ior efficacy ( sodium cacodylate 0 discuss$ 7,! ,j\rnal1 ,m>* #be1 #aiaf1 p4 #igh7 & ! wor?lessness ( sodium cacodylate z a spiro*eticide confirm$ by ,h4 ,n4 ,cole 7,! ,j\rnal1 ,dec4 #cj1 #aiaf1 p4 #bjab71 ,william ,g4 ,w>d 7,! ,j\rnal1 ,feb4 #c1 #aiag1 p4 #cij71 & ,r4 ,l4 ,sutton 7,! ,j\rnal1 ,feb4 #ag1 #aiag1 p4 #eff74 ,endosal1 l ,v5osal ( ! ,intrav5\s ,products ,company ( ,d5v]1 is said to conta9 salicylate & a col*icum prep>ation 7! latt] is also said to conta9 iodids74 ,v5osal 0 f\nd unacceptable = ,new & ,non(ficial ,rem$ies by ! ,c\ncil on ,ph>macy & ,*emi/ry4 ,l o!r 8intrav5\s0 firms1 ?is company adv]tises ! intrav5\s adm9i/ration ( drugs su* z sodium iodid & hexame?yl5am94 ,! objections to & ! dang]s ( indiscrim9ate adm9i/ration ( drugs intrav5\sly 0 rec5tly emphasiz$ 9 a report ( ! ,c\ncil on ,ph>macy & ,*emi/ry 8,"s ( ,loes]'s ,intrav5\s ,solutions0 7,! ,j\rnal1 ,april #af1 #aiba1 p4 #aabj74--7,qu]y f ,! ,j\rnal ,a4 ,m4 ,a41 ,dec4 #aj1 #aiba47 ,,iodex ,at fairly frequ5t int]vals physicians receive ?r\gh ! mail free samples ( 8,iodex10 a black o9tm5t s5t out 9 small1 circul> alum9um boxes4 ,iodex is sold by ,m5ley & ,james1 ,ltd41 ,new ,york ,city1 "u ! claim t x is a prep>ation ( free iod91#beb m9us ! objectionable features t g ) free iod94 ,! prep>ation 0 exam9$ 9 ! ,a4 ,m4 ,a4 ,*emical ,laboratory 9 #aiae1 & f\nd practically devoid ( free iod94 ,! laboratory also report$ t :5 #a or #b grams ( ,iodex 0 rubb$ on ! sk9 ( ! =e>m on sev]al subjects & ! ur9e collect$ & te/$ = iod91 ! results 7 negative4 ,?is disprov$ ! claim t 8?irty m9utes aft] inunction ) ,iodex iod9e c be f\nd 9 ! ur9e40 #beb 8,free0 or elem5t>y iod9 7su* z ! t9cture ( iod97 is us$ ext]nally = its local irritant & antiseptic effects4 8,comb9$ iod90 7e4 g41 iodid ( potassium71 does n produce ^! effects2 & :5 prep>ations conta9+ iod9 9 comb9$ =m are us$1 x is ) ! expectation ( obta9+ ! sy/emic 78alt]ative07 effects su* z are produc$ by iodids4 ,! f9d+s ( ! laboratory1 :i* 7 summ$ up 9 a report 7,! ,j\rnal1 ,june #ai1 #aiae7 ( ! ,c\ncil on ,ph>macy & ,*emi/ry on ,iodex1 7 ess5tially z foll[s3 #a4 ,! composition is incorrectly /at$2 ! actual iod9 cont5t is only ab\t half ( t claim$4 #b4 ,! action ( ,iodex is n ess5tially t ( free iod91 al?\gh t is ! impression convey$ by ! adv]tis+4 #c4 ,! ass]tion t iod9 may be f\nd 9 ! ur9e %ortly aft] ,iodex has be5 rubb$ on ! sk9 has be5 exp]im5tally disprov$4 ,at ! "t ! laboratory report$ its f9d+s1 x po9t$ out ! obvi\s contradiction 9 ! claim t ,iodex is n only an 8effective free iod9e application )\t drawbacks0 b also a means ( 8really effici5t ext]nal iod9e !rapy )\t /a9 or irritation40 ,x is impossible to h free iod9 pres5t 9 suffici5t quantities to be !rapeutically effici5t & n get sk9 /a9s & irritation4 ,9 a rec5t issue ( ! h\se organ1 ,ph>macal ,advance1 !re 0 a l>ge display adv]tisem5t ( ,iodex "u ! head+3 8,= prophylaxis & to #8,d\ble ,cross' ,disease10 ) ! claims3 8,free ,iod9e40 8,rub ,?r\gh ,sk940 8,does ,n ,irritate nor ,/a940 ,on o!r pages ( ! same issue ^! claims appe>$3 8,!re is no !rapeutic virtue 9 ,iodex :i* is n inh]5t--?\gh (t5 lat5t--9 ,free ,iod9e2 & !re is no virtue 9 ,free ,iod9e :i* is n available 9 ,iodex40 8,9 ,iodex all ! b5efic5t prop]ties ( ,iod9e are emphasiz$ & all its disadvantages are elim9at$--9 a ^w1 ,iodex is ,pure ,free ,iod9e pres5t$ !rapeutically active & effici5t1 ready = use 9 all conditions1 ) all ! well-kn[n p[]s ( ,free ,iod9e1 b )\t ! sequel ( unpleasant effects1 z irritation1 corrosion1 desquamation1 /a9+1 etc41 :i* defeat ! ends ( treatm5t :5 ord9>y prep>ations ( ,iod9e are us$4 ,! fact t ,free ,iod9e 9 ! =m ( ,iodex c n[ be us$ 9 rectal & vag9al treatm5t1 )\t irritation1 speaks volumes = its p5etrability & bl& action40 ,^! quotations are suffici5t to %[ t ! manufactur]s ( ,iodex /ill p]si/ 9 _! claim t ! product conta9s free iod94 ,9 view ( ?is1 ! ,a4 ,m4 ,a4 ,*emical ,laboratory has aga9 exam9$ ,iodex1 hav+ rec5tly pur*as$ specim5s on ! op5 m>ket4 ,x reports t ,iodex gives no te/ = free iod91 or at mo/1 b m9ute traces4 ,an int]e/+ side-light on ! me?ods ( ,m5ley & ,james is also br\ght out 9 ! issue ( ,ph>macal ,advance j quot$4 ,"u a 8dep>tm5t0 misnam$ 8,book ,reviews0 ! foll[+ appe>s3 8,,! ,,actions ,,( ,,drugs4--,torald ,sollmann1 ,m4,d4 ,publi%$ by ,w4 ,b4 ,saund]s ,co41 ,philadelphia4 ,?is is a book ( lectures design$ = /ud5ts 9 ph>macy & deals ) ! subject 9 pla9 & simple language4 ,! au?or 9 8 introduction has br\ght out ! fact t ov]-c\nt] prescrib+ is baneful bo? to ! public & to ! ph>maci/ himself4 ,among "s ( ! int]e/+ po9ts br\ght out t ,ph>macol ,advance has always ma9ta9$1 namely1 t #8,potassium iodid is n absorb$ effici5tly by ! sk92 h5ce ! o9tm5t ( potassium iodid is unsci5tific4' 8,we w\ld especially call att5tion to ,ungt4 ,iodi ,u4 ,s4 ,p41 conta9+ ,potassium ,iodid1 us$ z a solv5t = its iod9 cont5t4 ,accept+ ,sollmann's /atem5t1 x is to be assum$ t ,ungt4 ,iodi ,u4 ,s4 ,p4 has n #ajj p] c5t4 effici5cy40 ,g>bl+ /atem5ts f sci5tific works = ! purpose ( puff+ propriet>ies is n unusual 9 no/rum exploitation4 ,! facts are t ! /atem5t 9 ,sollmann's book1 introduc$ 9 ! ,m5ley & ,james h\se organ "u ! guise ( a book review1 appe>$ 9 a discussion ( iod9 comp\nds4 ,9 ?is ! au?or po9ts out t to obta9 sy/emic iodid effects1 x is irrational to apply iod9 prep>ations ext]nally4 ,s f> z ! free iod9 cont5t ( ! (ficial o9tm5t ( iod9 is conc]n$1 ,l4 ,e4 ,w>r5 7,reports ( ! ,a4 ,m4 ,a4 ,*emical ,laboratory1 #aiag7 has %[n t ev5 aft] m ?an six mon?s ?is o9tm5t /ill conta9s ab\t #ge p] c5t4 ( ! free iod9 orig9ally add$4 ,! (ficial o9tm5t 7,ungu5tum ,iodi1 ,u4 ,s4 ,p471 !re=e1 s f> z its free iod9 cont5t is conc]n$1 is f> sup]ior to ,iodex1 :i* conta9s no iod9 9 its free /ate4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,may #c1 #aiai47 ,,! ,,william ,f4 ,,ko* ,,canc] ,,rem$y ,a numb] ( inquiries h be5 receiv$ ( :i* ^? t foll[ are typical4 ,?is f a ,philadelphia physician3 8,w\ld y give me any in=mation y h ab\t "o s-call$ #8,dr4 ,w4 ,s4 ,ko*1' ,detroit1 ,mi*igan8 ,?is man is said to claim to h 9 8 possession a cure = canc]1 ! nature ( :i* ,i d n "k4 ,i "k1 h[ev]1 t he obta9$ a v l>ge fee n v long ago 9 treat+ a case1 b )\t success 4440 ,:ile a ,*icago physician writes3 8,i h at h& a pamphlet f ,wm4 ,f4 ,ko*1 ,m4,d41 ,ph4,d41 ( ,detroit1 ,mi*41 :i* is suppos$ to be a repr9t f ! ,m$ical ,record ( ,oct4 #cj1 #aibj1 entitl$ #8,a ,new & ,successful ,diagnosis & ,treatm5t ( ,canc]4' ,w y k9dly advise me :at y "k ab\t ?is man's "w on ?is subject & h[ mu* /ock ,i c put 9 ! claims he makes 9 ?is article80 ,& ?is f a physician 9 ,seattle1 receiv$ a few days ago3 8,has y\r (fice any k ( ! canc] cure devis$ by ,dr4 ,william ,f4 ,ko*1 ,ph4,d41 ,m4,d41 ( ,detroit8 ,he publi%$ an article on x 9 ! ,m$ical ,record1 ,oct4 #cj1 #aibj4444 ,i enclose copy ( lett] receiv$ by "o ( our pati5ts f 8 #8we/]n repres5tative' :i* reads l pure quack]y4 ,i d n f9d ,dr4 ,ko*'s "n 9 ei!r ! ,a4 ,m4 ,a4 or ,polk's m$ical directories40 ,! lett] ref]r$ to 9 ! la/ inquiry z com+ f ,dr4 ,ko*'s 8we/]n repres5tative0 0 address$ to a woman :o _h writt5 to ,dr4 ,ko* ) ref]5ce to 8 alleg$ canc] cure4 ,! lett]1 dat$ ,jan4 #ai1 #aiba1 0 sign$ 8,*as4 ,l4 ,tisdale1 #ahih ,ge>y ,/reet1 ,san ,francisco40 ,x read3 8,de> ,madam3--,y\r lett] ( ,janu>y #aj? writt5 to ,dr4 ,ko* ( ,detroit 9 ref]5ce to 8 canc] cure has be5 s5t to me by ,dr4 ,ko*4 ,i am ! we/]n repres5tative ( ,dr4 ,ko* & am giv+ ! treatm5ts ) 8 rem$y4 ,i am n[ treat+ #ad cases "h ) "s mo/ wond]ful results4 ,! am\nt ( ! rem$y t ,dr4 ,ko* c supply me ) is limit$ & x is a v exp5sive sub/ance4 ,none ( x c be s5t to ,seattle or any o!r place = ,i h only en\gh to treat ! cases t are con/antly pres5t+ !mselves "h4 ,if y c\ld come to ,san ,francisco & h ! money to pay a reasonable fee1 say en\gh to pay = ! rem$y1 ,i w\ld be v glad to d ev]y?+ ,i c = y4 8,! results t h already %[n 9 _m ( ^! cases w>rant me 9 believ+ t almo/ any case ( canc] c be cur$ if ! treatm5t is p]si/$ 940 ,accord+ to our records1 ,dr4 ,william ,f4 ,ko* ( ,detroit 0 born 9 #ahhe4 ,"s ye>s ago he graduat$ 9 *emi/ry & = "s "t held ! position ( pr(essor ( physiology & physiologic *emi/ry at ! ,detroit ,college ( ,m$ic9e & ,surg]y4 ,9 #aiah1 ,dr4 ,ko* receiv$ 8 degree 9 m$ic9e f ?is same college4 ,less ?an a ye> aft] 8 graduation1 ,dr4 ,ko* decl>$ t he _h 8develop$ a real specific cure = canc]40 ,9 ! ,detroit ,m$ical ,j\rnal = ,july1 #aiai1 !re appe>$ a brief article by ,william ,f4 ,ko*1 entitl$ 8,a ,new & ,successful ,treatm5t & ,diagnosis ( ,canc]40 ,a m ext5sive article be>+ ! same title 0 publi%$ 9 ! ,new ,york ,m$ical ,j\rnal ( ,oct4 #cj1 #aibj4 ,z a result ( ! publicity t 0 giv5 ! ,ko* treatm5t1 ! ,wayne ,c\nty 7,detroit7 ,m$ical ,society appo9t$ a committee to inve/igate ! treatm5t4 ,its fir/ report appe>$ 9 ! ,bullet9 ( ! society = ,dec4 #bb1 #aiai4 ,briefly1 ?is report said t ! ,bo>d ( ,heal? ( ,detroit _h plac$ at ! disposal ( ! committee twelve b$s 9 a local hospital ) ! necess>y special nurses & ev]y?+ else requir$ free ( *>ge4 ,! committee s5t c]ta9 pati5ts to ! hospital2 & !re 7 also "s o!r pati5ts recomm5d$ by diff]5t physicians z prop] cases = treatm5t4 ,!re 7 n9e altoge!r4 ,aft] go+ ov] ! cases c>efully1 ! committee f\nd "s 9 :i* ! diagnosis 0 d\btful4 ,!re 7 five cases1 h[ev]1 ( und\bt$ canc]1 a positive diagnosis hav+ be5 made f specim5s & microscopic exam9ation4 ,! managem5t & treatm5t ( ^! pati5ts 7 turn$ ov] to ,dr4 ,ko*4 ,dr4 ,ko* seems to h rais$ c]ta9 objections & to h made c]ta9 criticisms4 ,he also insi/$ t he ought to h "s repres5tative on ! committee4 ,! committee (f]$ to put on any & all he w\ld "n4 ,he fail$ to "n any4 ,! committee report$ fur!r t ,dr4 ,ko* 0 v neglig5t 9 8 treatm5t ( ! pati5ts & f9ally1 on ,novemb] #bf1 ! committee met ) ,ko* & w5t ov] all ! cases ) him4 ,at t "t he gave ! pati5ts injections & promis$ to att5d to ! treatm5t regul>ly 9 ! future4 ,accord+ to ! report1 he saw ! pati5ts only once m 7?ree days lat]7 & !n did n come ne> !m aga94 ,z ! pati5ts became disgu/$ ) ! neglect1 "s ( !m left & ! committee s5t ! re/ home & clos$ its connections ) ! inve/igation ( ! subject4 ,9 ! same issue ( ! ,bullet9 ( ! c\nty society 9 :i* ?is committee's report 0 publi%$1 ! editor ( ! ,bullet9 /at$ t f all sections ( ! c\ntry inquiries 7 com+ relative to ! treatm5t & 8f long di/ances pati5ts are com+ to ,detroit to be #8cur$' ( canc]40 ,! editor fur!r /at$3 8,x is report$ t ,dr4 ,ko* is treat+ _m pati5ts1 promis+ mu* & *>g+ well40 ,to ?is ,dr4 ,ko* retort$ t only ab\t #cj p] c5t4 ( 8 pati5ts _h 8contribut$40 ,! re/ 7 treat$ free4 ,! ,wayne ,c\nty ,m$ical ,society ,bullet9 = ,jan4 #e1 #aibj1 0 devot$ almo/ exclusively to ano!r discussion ( ,dr4 ,ko*'s 8canc] cure40 ,x 0 !re /at$ t a second committee _h be5 appo9t$ to ga!r :at in=mation c\ld be obta9$ f outside s\rces relative to cases treat$ by ,dr4 ,ko*4 ,?is committee report$ t ( fifty-six cases ( :i* x 0 able to obta9 data1 only ?ree ( ! pati5ts %[$ cl9ical improvem5t2 tw5ty-"o ( ! pati5ts 7 dead4 ,?ree m pati5ts treat$ bo? by ! ,ko* injections & by op]ation 7 report$ z cl9ically improv$4 ,! condition ( eighte5 ( ! pati5ts 0 report$ z /ation>y1 or unimprov$4 ,9 elev5 ( ! cases1 ! results 7 unkn[n b ! surgeons report$ unfavorably4 ,! committee report$ fur!r t ,dr4 ,ko*'s records 7 incomplete & t he _h submitt$ no pro( t 8 injections h any p>ticul> m]it & ! committee conclud$ t ! /udy 8is entirely exp]im5tal & improp]ly sup]vis$40 ,evid5tly1 ! mo/ t c be said ( ,dr4 ,ko*'s alleg$ 8cure0 = canc] is t ! claims made = x h n be5 support$ by indep5d5t inve/igators4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,feb4 #ab1 #aiba47 ,fur!r ,comm5t ,la/ week "s space 0 giv5 to ! alleg$ cure = canc] put out by ,dr4 ,william ,f4 ,ko* ( ,detroit4 ,incid5tally1 x %\ld be m5tion$ t ,dr4 ,ko*'s article ( ,oct4 #cj1 #aibj1 to :i* ref]5ce 0 made1 appe>$ n 9 ! ,new ,york ,m$ical ,j\rnal1 z /at$1 b 9 ! ,new ,york ,m$ical ,record4 ,! foll[+ correspond5ce ?r[s additional light on ! subject3 ,to ! ,editor3--,to ! numb] ( inquiries :i* y h receiv$ reg>d+ ! alleg$ cure ( canc] by ,dr4 ,ko*1 p]mit me to add ! foll[+ p]sonal exp]i5ce4 ,on ,july #a1 #aibj1 ,i 0 ask$ to exam9e an ex-pati5t ( m9e :om ,i _h n se5 pr(essionally = _m ye>s4 ,h] husb& frankly told me t = sev]al mon?s 8 wife _h be5 treat$ by ,dr4 ,w4 ,f4 ,ko* = inop]able c>c9oma ( ! pelvic organs1 t he wi%$ ,dr4 ,ko* to reta9 *>ge ( ! treatm5t b hop$ ,i w\ld give my op9ion reg>d+ c]ta9 n]v\s manife/ations 9 ! pati5t :i* 7 caus+ him 7h] husb&7 mu* conc]n4 ,at ! same "t1 he %[$ me a lett] writt5 by ,dr4 ,ko* purport+ to expla9 ! symptoms & (f]+ sugge/ions reg>d+ treatm5t4 ,i call$ on ! pati5t & f\nd h] 9 ! la/ /ages ( g5]aliz$ c>c9omatosis4 ,simple palpation ( ! abdom5 reveal$ multiple nodules involv+ bo? l[] & upp] abdom9al quadrants4 ,i did n feel ju/ifi$ 9 mak+ a pelvic exam9ation b not$ a pr(use f\l-smell+ dis*>ge on ! vulv> pad4 ,my prognosis did n meet ) ! delud$ husb&'s approval4 ,! pati5t di$ )9 a week & a necropsy confirm$ ! cl9ical picture ( c>c9omatosis4 ,enclos$ is ,dr4 ,ko*'s lett]2 ! pati5t's "n %\ld1 ( c\rse1 be omitt$ if y see fit to publi% ?is note4 ,george de ,t>n[sky1 ,m4,d41 ,*icago4 ,! lett] f ,dr4 ,ko* :i* ,dr4 de ,t>n[sky enclos$ ) 8 own1 foll[s4 ,we h1 ( c\rse1 delet$ ! "n ( ! pati5t4 ,de> ,doctor3 ,mrs4 ---- has absorb$ & is /ill absorb+ "s kill$ tumor tissue4 ,%e has absorb$ "s ?ree p\nds1 ,i judge4 ,! results ( ! absorption are intoxication q g5]al 7n]v\s1 muscul>1 p]haps nephritic74 ,! myoc>dium at pres5t %[s no signs ( poison+ b ! skeletal muscles & n]ve d4 ,! important tox9 lib]at$ by ! kill$ tissue is me?yl cyanimide :i* comb9es ammonia 7,,nh7 f ! am9o acids1 & ?us becomes me?yl guanid9e4 ,?is latt] has produc$ 9 my pati5ts an intoxication v>y+ 9 simil>ity to3 idiopa?ic tetany 9 *ildr51 *orea 9 *ildr51 eclampsia 9 wom51 & has ev5 be5 s sev]e z tetanus 9 "s ( ! muscle spasms2 a toxic album9uria has result$ 9 "s ( my cases4 ,all ( my cases h clean$ up s f>4 ,( c\rse1 ,i _c pr$ict 9 any individual case1 except t :5 ! absorption has be5 complet$ & ! tox9 all elim9at$1 ev]y?+ %\ld return to normal1 unless ! tox9 has de/roy$ tissue beyond physiological repair4 ,my sugge/ions z to treatm5t w\ld be elim9ation1 sav+ ! kidneys z mu* z possible1 by :atev] me?ods y f9d be/ & necess>y4 ,at pres5t ,i am treat+ symptomatically ?us--atrop9 z a guanid9e antidote1 ars5ic z a *orea c\pl$ antidote z a prev5tion to ! production ( guanid9e f ! cyanimide1 ! use ( dilute hydro*loric acid has prov5 successful to me4 ,ev5 a ur9e boil+ solid--album5 has cle>$ up 9 "o case 9 ?ree days j by tak+ l>ge quantities ( #a_/b p] c5t ,h,cl4 ,i am expla9+ ! factors ,i h cont5d$ ) 9 ^! cases1 b d n want to influ5ce y\r plan ( treatm5t :5 y\r judgm5t f9ds me insuffici5t4 ,s9c]ely1 ,wm4 ,f4 ,ko*4 ,i %all h a publication out v soon on ! treatm5t ( ^! tetanics & eclampsia ) ,h,cl4 ,x is wor? not+ t ?is lett] ( ,dr4 ,ko*'s 0 writt5 ,june #bh1 j ?ree days be=e ,dr4 de ,t>n[sky saw ,mrs4 ---- & less ?an a week be=e %e di$ ( g5]aliz$ c>c9oma4 ,n ! lea/ important elem5t 9 ! /ory :i* ^! two lett]s tell is ! optimism eng5d]$ 9 ! husb& ( ! poor canc] pati5t by ! widely vaunt$ treatm5t ( ,ko*4 ,& h]e9 lies "o ( ! mo/ p]nici\s features connect$ ) ! exploitation ( alleg$ cures = canc]1 tub]culosis1 etc4 ,all su* rem$ies1 :e!r fraudul5t bo? 9 _! inception & exploitation or ^? :i* :ile equally wor?less are at lea/ hone/ly put =w>d & are bas$ on a c]ta9 am\nt ( sci5tific inve/igation1 produce a pr(\nd & m>k$ tempor>y *ange 9 ! pati5t's condition4 ,x is ?is t t5ds to w>p ! judgm5t n only ( ! unsci5tific layman1 b also ( ! physician4 ,! psy*ic elem5t 9 canc] has be5 well describ$ by ,weil3 8,x is1 inde$1 v rem>kable t a pati5t :o has be5 consign$ to dea? z a victim ( a hopeless malady1 %\ld rega9 8 spirits & 8 appetite1 :5 he is aga9 confront$ ) ! hope ( a cure1 & ( ! eradication ( 8 disease8 ,x is a ph5om5on well kn[n to e /ud5t ( ! disease t a l>ge proportion ( cases responds 9 j ?is mann] to any treatm5t :i* is (f]$ !m4 ,osl] has describ$ a case ( canc] ( ! /oma* 9 :i* ! m]e visit to a consultant ( sangu9e temp]am5t1 ?\gh poor judgm5t1 ^: assurance ( ! pati5t t !re 0 no possibility ( canc]1 result$ 9 ! disappe>ance ( all ! symptoms & a ga9 ( #ah p\nds 9 weight4 ,x is ?is psy*ic influ5ce1 :i* has occasionally delud$ ! hone/ /ud5t ( canc] cure1 & :i* has also s g5]\sly play$ into ! h&s ( ! di%one/40--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,feb4 #ai1 #aiba47 ,,! ,,lucas ,,laboratories' ,,products ,! ,j\rnal has receiv$ sev]al inquiries ab\t ! products put out by ! ,lucas ,laboratories1 ,incorporat$1 ( ,new ,york ,city4 ,a typical inquiry is t receiv$ f ,dr4 ,f4 ,a4 ,jewett ( ,brooklyn1 :o writes3 8,! enclos$ circul> is s5t out to ! m$ical pr(ession by ,dr4 ,william ,lucas1 #bhg ,w4 #gj? ,/41 ,new ,york4 ,:at d y "k ( ?is man & 8 me?ods80 ,william ,h4 ,lucas 0 graduat$ by ! ,m$ical ,college ( ,ohio 9 #ahie & 0 lic5s$ 9 #ahig4 ,he is n a memb] ( 8 local m$ical society4 ,! products put out by ! ,lucas ,laboratories are = intrav5\s use1 & _! me?od ( exploitation indicates t ! conc]n is less int]e/$ 9 ! sci5ce ( !rapeutics ?an x is 9 tak+ comm]cial advantage ( ! pres5t fad = intrav5\s m$ication4 ,! ,j\rnal has prote/$ editorially aga9/ ! unnecess>y use ( ! intrav5\s adm9i/ration ( drugs1 & ! abuse ( ?is me?od ( drug giv+ prompt$ ! ,c\ncil on ,ph>macy & ,*emi/ry rec5tly to emphasize ! dang] ( indiscrim9ate intrav5\s m$ication4 ,! products ( ! ,lucas ,laboratories1 ,inc41 h n be5 exam9$ ei!r by ! ,a4 ,m4 ,a4 ,*emical ,laboratory or by ! ,c\ncil on ,ph>macy & ,*emi/ry4 ,! composition ( ^! products is ess5tially secret1 :i* 9 itself %\ld be suffici5t to det] physicians f us+ !m4 ,( c\rse1 9 accordance ) all ! t55ts ( or?odox no/rum exploitation1 8=mulas0 are furni%$4 ,ev5 ! crude hi]oglyphics t us$ to be palm$ (f on ! m$ical pr(ession by no/rum exploit]s "u ! guise ( 8graphic =mulas0 are outdone by ! ,lucas ,laboratories 9 publi%+ ! alleg$ =mulas ( its prep>ations4 ,if we1 z physicians1 knew m *emi/ry1 ! ,lucas ,laboratories w\ld n f9d x pr(itable to publi% su* ineffable nons5se z t :i* *>act]izes _! 8lit]ature40 ,= in/ance3 8#8,luve9' ,arsans 7,pla970 is said to be3 8,di hypo sodio calcio phosphite hydroxy ars5o m]curic iodid40 ,! fir/ "p ( ?is 8=mula0 might /& = sodium & calcium hypophosphite4 ,! rema9d] is mean+less except t x sugge/s 7b does n insure7 ! pres5ce ( ars5ic & m]cury iodide4 8#8,luve9' ,arsans1 ,nos4 #a1 #b & #c40--8,meta hydroxy iodide sodio arsano m]curic dime?yl b5zo sodio ars5ate1 ai oxy sodio t>t>ia sulpho di%euyl hydraz940 ,:o c v5ture ev5 a conjecture z to ! possible significance ( ?is8 8#8,luve9' ,creosophite40--8,ammonio hydroxy calcio sodio hypo-phosphite ars5\s p5toxy iodide40 ,:ile ! "n sugge/s creosote1 ! 8=mula0 gives no h9t ( ?is4 ,x might ref] to hypophosphites ( ammonium1 calcium & sodium ) iodide ( ars5ic4 ,:e!r ars5\s 7trival5t ars5ic7 or ars5ic 7p5taval5t ars5ic7 iodide or bo? are int5d$1 is a "q4 8#8,luve9' ,hexacol40--8,hexa me?yl5epyro cate*9 mono me?yl am9o e!r glyc]ite40 ,by mov+ ^! syllables ar\nd l ! old 8fifte5 puzzle0 !y c be arrang$ to repres5t hexame?yl5am9 & monome?yl-e!r ( pyrocate*91 or guaiacol1 hav+ ! 8glyc]ite0 left ov]4 ,x is futile to discuss ! !rapeutic claims made = ! v>i\s prep>ations put out by ! ,lucas ,laboratories4 ,"o might z pr(itably discuss ! !rapeutic claims made = 8,p]una0 or 8,pa9e's ,cel]y ,comp\nd0 = ! exploitation ( ! latt] products is on j z high a sci5tific plane z ! exploitation ( ! 8,luve90 no/rums4 ,! proposition (f]$ to physicians by ! ,lucas ,laboratories1 ,inc41 is an insult to ! intellig5ce ( ! m$ical pr(ession4 ,n t ! products !mselves are necess>ily any worse or any bett] ?an _m (f]$ = intrav5\s use2 ! sell+ me?ods are m crude1 t is all4 ,! facts are1 we h ent]$ a new cycle ( no/rum developm5t4 ,! unsci5tific mixtures = oral adm9i/ration t *>act]iz$ s l>ge & disreputable a "p ( ! propriet>y m$ic9e bus9ess ( ! pa/ two or ?ree decades are giv+ way to equally unsci5tific mixtures = intrav5\s use4 ,! dang]s ( ! old] no/rums are acc5tuat$ 9 ! new] by ! add$ elem5t ( risk t is insep>able f intrav5\s !rapy4 ,add to ?is ! temptation to ! physician 9 ! way ( m sub/antial fees :i*1 legitimately en\gh1 may be *>g$ :5 intrav5\s adm9i/ration is call$ =1 & ! m5ace ( ! new /yle no/rum becomes evid5t4 ,! ,j\rnal c only reit]ate ! w>n+ t intrav5\s !rapy %\ld be employ$ only :5 mo/ positively indicat$4 ,fur!r1 because ( ! dang] t is insep>able f ?is me?od ( drug adm9i/ration1 physicians %\ld be d\bly c>eful to see t products employ$ = intrav5\s use come f firms ( unque/ion$ sci5tific /&+4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,sept4 #bj1 #aiai47 8,,phylacog5s0,l ,l ,?is matt] 0 l>gely repr9t$ 9 ! ,propag&a = ,re=m1 eigh? & n9? editions4 ,a physician 9 ,florida writes3 8,i am enclos+ a copy ( a circul> lett] j receiv$ f ,p>ke1 ,davis ,company1 & w call y\r att5tion to a m>k$ p>agraph 9 ?is lett] on :i* ,i w\ld l to h an expression ( y\r op9ion40 ,! circul> lett] :i* ! doctor =w>ds is devot$ to s++ ! praises ( 8,pneumonia ,phylacog540 ,x op5s ) ! /atem5t3 8,influ5za1 we le>n1 has appe>$ 9 y\r section40 ,! p>agraph m>k$ by our correspond5t reads3 8,pneumonia ,phylacog5 has be5 f\nd to be a dep5dable means ( prev5t+ & treat+ pneumonic complications ( ,influ5za4 ,9 "o l>ge city x became a r\t9e measure to give all p]sons affect$ ) ,influ5za an injection ( ,pneumonia ,phylacog5 z a prophylactic ( pneumonia4 ,! results 7 rem>kable4 ,n only did ! cases improve rapidly1 b 9 a great majority ( !m ! pneumonia did n occur40 ,! 8,phylacog5s0 7 repeat$ly discuss$ 9 ,! ,j\rnal dur+ #aiac & #aiad :5 ^! products 7 be+ pu%$ ) mu* vigor by ! manufactur]s4 ,we "k ( no evid5ce t calls = a revision ( ! /atem5ts !n made reg>d+ !m4 ,! injection ( phylacog5s is simply ! adm9i/ration ( a mixture ( ! filt]$ products ( sev]al bact]ial species4 ,! results :i* foll[ repres5t ! reaction ( ! bact]ial prote9--a reaction = good or evil4 ,!re is no sci5tific evid5ce to %[ t !y possess any specific prophylactic virtue4 ,to recomm5d _! use 9 cases ( influ5za1 z a prophylactic aga9/ pneumonia1 is unw>rant$1 & ! physician :o acts on ! advice ( ! manufactur] mu/ assume ! responsibility = ! results4 ,9 case ( mi%ap he _c fall back on ! manufactur]2 he w f9d no sci5tific evid5ce to support him4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #ae1 #aiai47 ,,p9eoleum ,,adv]tis+ ,,me?ods ,capitaliz+ ! ,"n & ,position ( ! ,presid5t ( ! ,am]ican ,m$ical ,association ,to ! ,editor3--,enclos$ is a po/al c>d :i* a physician 9 ,oklahoma has s5t me toge!r ) ?irty-six c5ts 9 /amps4 ,! envelop 0 address$ to me at ! address ( ! ,p9eoleum ,company4 ,! po/(fice correct$ ! address & s5t x to me4 ,x is evid5t1 !re=e1 t ! physician 9 ,oklahoma ?\ght ,i 0 s5d+ ^! po/als z an employee ( ! ,p9eoleum ,company1 or1 at lea/1 0 endors+ _! products4 ,illu/ration3 ---------------------------------------- ----------------------------- ,,treatm5t ,,( ,,influ5za #djh-aj-ab ,we/ #ac? ,/reet ,by ,a4 ,,lamb]t1 ,m4 ,d41 ,new ,york4 ,pres4 ,a4 ,m4 ,a4 ,new ,york ,city ,de> ,doctor3 8,! #8,flu' is com+ back 9 ,octob] to sc\rge ! :ole _w4 ,i expect ! plague to come back z soon z p beg9 to live indoors aga94 ,! dea? toll ,w be s]i\s1 b ,i d n expect x w be z bad z x 0 la/ w9t]40 --,dr4 ,royal ,s4 ,copel&1 ,*ief ( ! ,new ,york ,heal? ,dep>tm5t4 8,! p]si/5t spray+ ( ! nose & ph>ynx ) "s =m ( silv] salt1 or "s =m ( mild dis9fectant1 mat]ially aids 9 conf9+ ! infection 9 its e>ly /ages to ! upp] passages1 & ?is proc$ure gives ! impression1 :5 tri$ 9 a l>ge numb] ( pati5ts1 t x prev5ts 9 _m cases ! spread d[n- w>d into ! bron*i & ?us limits pulmon>y complications40 --,extract f 8,! ,treatm5t ( ,influ5za10 by ,a4 ,lamb]t1 ,m4,d41 9 ! ,j\rnal ( ! ,am]ican ,m$ical ,association1 ,augu/ #bnd1 #aiai4 ,we h lett]s f a l>ge numb] ( physicians confirm+ ! above extract1 & ) ! fur!r /atem5t t z a prev5tive & reliev+ ag5t !re is no comb9ation be=e ! pr(ession today s satisfactory z ,p9eoleum4 ,if y h n receiv$ rec5tly1 a complim5t>y ,outfit1 return ?is c>d ) #cf c5ts 9 /amps & we w =w>d a regul> #a4jj package by prepaid ,p>cels ,po/4 ,,! ,,p9eoleum ,,company ---------------------------------------- ----------------------------- ,po/al c>d capitaliz+ ! "n & position ( ! ,presid5t ( ! ,am]ican ,m$ical ,association4 ,k9dly d me ! favor to publi% ?is lett] 9 ,! ,j\rnal z a prote/ aga9/ ! di%one/y ( ?is me?od ( adv]tis+4 ,:at is quot$ f an article t ,i wrote appe>$ orig9ally 9 ! ,new ,york ,/ate ,j\rnal ( ,m$ic9e & 0 ab/ract$ 9 ,! ,j\rnal ( ! ,am]ican ,m$ical ,association ( ,augu/ #b1 #aiai4 ,! obvi\s inf]5ce to be drawn f ?is po/al is t ,i ref]r$ to ! products ( ! ,p9eoleum ,company 9 t article4 ,i did n h ! products ( ! ,p9eoleum ,company 9 my m9d4 ,i nev] h us$ _! products & nev] prescrib$ !m4 ,?is =m ( adv]tis+ is done ) int5t to deceive & did deceive ! doctor 9 ,oklahoma4 ,x 0 !re=e a successful falsehood1 its success dep5d+ on ! false use ( ! "n ( ! ,presid5t ( ! ,am]ican ,m$ical ,association to bol/] up ! sale ( ! product4 ,i res5t ! use ( my "n 9 connection ) ! quack adv]tis+ ( no/rum v5d]s4 ,! l[1 vulp9e cunn+ ( ! me?od us$ is on ! same level z ! deceit & di%one/y :i* use ?is =m ( adv]tis+ to ! injury ( my "n & reputation4 ,z ,presid5t ( ! ,am]ican ,m$ical ,association ,i mu/ insi/ t y protect me by publi%+ ?is lett] 9 ,! ,j\rnal1 giv+ x z widespread publicity z possible4 ,alex&] ,lamb]t4 ,comm5t4--8,p9eoleum0 is a 8pat5t m$ic9e0 adv]tis$ 9 ! *eape/ & mo/ effective way--by ! aid ( ! easy go+ & complac5t physician4 ,9 #aijf ,p9eoleum 0 be+ m>ket$ by ! ,w9sl[ ,laboratory ( ,new ,york ,city1 :i* also put out ?ree or f\r o!r no/rums--8,morumalt10 8,eg]iol10 8,dige/yl910 & 8,=d's ,nucleo-,peptone40 ,p9eoleum 0 adv]tis$ to ! public !n z x is adv]tis$ n[1 via ! m$ical pr(ession4 ,physicians are circul>iz$ & are (f]$ a petty graft 9 ! =m ( a *eap nebuliz] & a sample bottle ( ,p9eoleum4 ,"s "t ago ! company seems to h develop$ a s*eme :]eby physicians c\ld make money 8disp5s+ ,p9eoleum nebuliz] outfits at m ?an #adj p] c5t4 pr(it40 ,! ,p9eoleum conc]n = ye>s has also pollut$ ! /ream at its s\rce by attempt+ to get ! secret>y ( ! s5ior class ( e m$ical s*ool to di/ribute its free nebuliz] outfits to memb]s ( ! class & receive !re= #e c5ts = ea* outfit di/ribut$6 ,! life hi/ory ( ,p9eoleum is t ( ! typical no/rum4 ,epidemics1 ( c\rse1 are utiliz$ z opportunities = pu%+ ! product4 ,9 #aiaa a c>d 0 s5t out featur+ 8,a ,special ,la,grippe ,(f]02 9 #aiaf ! pr(ession 0 circul>iz$ recomm5d+ ,p9eoleum z 8,! ,ideal ,prophylactic0 9 infantile p>alysis2 dur+ ! pa/ ye> influ5za has aga9 be5 ! sell+ po9t4 ,! case describ$ by ,dr4 ,lamb]t is n ! fir/ example ( ! misuse ( names & /atem5ts ( physicians4 ,la/ ,decemb] ! ,p9eoleum conc]n 0 s5d+ out an adv]tis+ c>d 9 :i* ,dr4 ,mc,coy ( ! ,unit$ ,/ates ,public ,heal? ,s]vice 0 quot$ z recomm5d+ ,p9eoleum z ! 8bulw>k ( prev5tion0 & 8batt]y ( relief0 9 influ5za4 ,( c\rse1 ,dr4 ,mc,coy nev] said any?+ ( ! sort4 ,a prote/ aga9/ ?is p>ticul> falsehood result$ 9 ano!r c>d be+ s5t out sev]al mon?s lat] by ! ,p9eoleum p purport+ to expla9 & apologize = ! misquotations & putt+ ! blame on ! pr9t]4 ,! 8apology0 end$ ) a po/script 79 l>g] & bold] face type ?an ! body ( ! c>d7 t urg$ physicians to 8secure our lib]al introductory adv]tis+ proposition on improv$ oil nebuliz] outfits40 ,f ! /&po9t ( publicity = ,p9eoleum1 ! 8explanation & apology0 0 d\btless z good an adv]tisem5t z ! orig9al c>d ( misrepres5tation4--,ed4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #a1 #aiai47 8,,proteal ,,!rapy0 ,,& ,,h5ry ,,smi? ,,williams ,to ! ,editor3--,w y please advise z to ! success & saf5ess 9 us+ ! ,proteal treatm5t = tub]culosis by ,h5ry ,smi? ,williams1 ,m4,d41 ,,ll4,d41 #ajd ,ea/ #dj? ,/reet1 ,new ,york8 ,c4 ,p4 ,bur*>d1 ,alamogordo1 ,n4 ,m4 ,to ! ,editor3--,k9dly s5d me any available in=mation on 8,! ,proteal ,treatm5t = ,canc]40 ,an article by ,dr4 ,h5ry ,smi? ,williams1 #abj ,we/ #cb ,/reet1 ,new ,york ,city1 9 ,april ,he>/'s has caus$ relatives to reque/ its use 9 a case ( c>c9oma ( ! liv] "u my c>e4 ,m4 ,m4 ,repp>d1 ,middleb\rne1 ,w4 ,va4 ,to ! ,editor3--,i am enclos+ a leaflet1 mail$ to me on reque/1 by ,dr4 ,h5ry ,smi? ,williams ( ,new ,york ,city1 :o publi%$ a s]ies ( articles dur+ ! la/ ye> 9 ,he>/'s ,magaz9e on 8,proteal ,!rapy40 ,if y h inve/igat$ ?is man & 8 proteal treatm5t1 ,i %\ld l to "k ! result ( y\r f9d+s4 ,i am a consumptive & am1 !re=e1 p>ticul>ly int]e/$ 9 its alleg$ b5efactions = ! treatm5t ( tub]culosis4 ,mi*ael ,a4 ,long1 ,gl5 ,lake ,sanit>ium1 ,hopk9s1 ,m9n4 ,to ! ,editor3--,:at in=mation c y give me reg>d+ ,h5ry ,smi? ,williams1 ,m4,d41 ,,ll4,d41 #ajd ,ea/ ,=tie? ,/reet1 ,new ,york1 & ! !rapeutic value ( ! 8,proteal ,!rapy0 t he has orig9at$8 ,m4 ,d4 ,bak]1 ,m4,d41 ,san ,jose1 ,calif4 ,! above lett]s are select$ f _m receiv$ on ! subject4 ,h5ry ,smi? ,williams is bett] kn[n 9 ! j\rnali/ic _w ?an 9 ! field ( sci5tific m$ic9e4 ,he 0 graduat$ by ! ,*icago ,m$ical ,college 9 #ahhd4 ,9 ! ?irte5 issues ( m$ical directories ( ! ,unit$ ,/ates t h be5 publi%$ dur+ ! pa/ ?irty ye>s ,dr4 ,williams' "n does n appe>--except = ! issues ( #ahij & #ahic--until ! #aiad edition4 ,s f> z we h be5 able to f9d1 ,dr4 ,williams _h n until #aiae contribut$ any articles to m$ical j\rnals4 ,! catalog ( ! ,surgeon ,g5]al's ,libr>y conta9s no ref]5ce to any articles ( ,dr4 ,williams except ^? t h appe>$ 9 popul> magaz9es4 ,! volumes ( ! ,index ,m$icus f #aijg until #aiad1 inclusive1 also conta9 no ref]5ces to any articles by him 9 m$ical j\rnals4 ,! ,j\rnal#8s au?or index to curr5t m$ical lit]ature f #aijj to #aiad1 inclusive1 fails to record any articles by ,dr4 ,williams 9 m$ical j\rnals4 ,dr4 ,williams' articles1 h[ev]1 9 popul> magaz9es h be5 volum9\s & num]\s4 ,sometimes 8 articles h be5 "u 8 own "n & sometimes "u ! nom de plume1 8,/odd>d ,goodhue1 ,m4,d40 ,"u ! latt] "n ! ,cosmopolitan publi%$ articles on 8,add+ ,ye>s to ,y\r ,life10 8,battle ( ! ,microbes10 8,d ,y ,*oose ,y\r ,*ildr580 & 8,:at is ! ,matt] ,) ,y\r ,bra980 ,"u 8 own "n articles h appe>$ 9 popul> magaz9es on su* subjects z 8,burbank's ,way ) ,fl[]s10 8,e ,woman ,h] ,own ,burbank10 8,:y ,n ,live ,=ev]80 8,sci5ce ( ,bre$+ ,k+s10 8,new ,canc] ,treatm5t0 & 8,new ,hope = ,rheumatism ,suff]]s40 ,9 addition1 ,dr4 ,williams has publi%$ books on su* subjects z 8,hi/ory ( ! ,art ( ,writ+10 8,hi/orians' ,hi/ory ( ! ,_w10 8,/ory ( ,n9ete5? ,c5tury ,sci5ce10 8,lu!r ,burbank10 8,twilight ,sleep0 & o!rs4 ,! ,goodhue ,company ( ,new ,york ,city1 :i* publi%es "s ( ,dr4 ,williams' books has1 we und]/&1 = its presid5t1 ,dr4 ,h5ry ,smi? ,williams1 = its vice presid5t1 ,dr4 ,williams' wife1 & = its secret>y-treasur]1 ,dr4 ,williams' daught]4 ,read]s ( ,! ,j\rnal w rememb] ! publicity giv5 9 #aiae & #aiaf to an alleg$ treatm5t = canc]1 sometimes call$ ! 8,hor[itz-,beebe ,autolys9 ,treatm5t40 ,! me?od 0 h]ald$ widely bo? 9 a c]ta9 portion ( ! m$ical press & 9 popul> magaz9es & newspap]s4 ,a popul> article by ,h5ry ,smi? ,williams on 8,! ,new ,canc] ,treatm5t0 appe>$ 9 ! ,illu/rat$ ,_w = ,octob]1 #aiae1 ) pictures ( ,dr4 ,hor[itz1 ,dr4 ,beebe1 etc4 ,a mon? or two lat]1 physicians receiv$1 gratis1 f ! ,goodhue ,company a neatly b\nd little book on 8,alcohol ,hygi5e & ,legislation10 by ,e4 ,h4 ,williams1 ,m4,d4 7bro!r ( ,h5ry ,smi? ,williams74 ,enclos$ ) x 0 a lett] f ! ,goodhue ,company ask+ physicians to accept ! book4 ,! body ( ! lett] 0 devot$ to call+ ! att5tion ( physicians to an 8important "w0 by ,dr4 ,h5ry ,smi? ,williams on 8,! ,autolys9 ,treatm5t ( ,canc]0 t ! ,goodhue ,company 0 publi%+4 ,) ! lett]1 !re 0 a small adv]tis+ pamphlet 8,issu$ by ! ,autolys9 ,laboratory0 & adv]tis+ t product4 ,9 addition1 ! la/ ?irte5 pages ( ! book on 8,alcohol ,hygi5e0 conta9$ adv]tisem5ts ( ! ,goodhue ,company's publications ) p>ticul> emphasis 7f\r pages ( x7 on ! 8,autolys9 ,treatm5t ( ,canc]10 by ,h5ry ,smi? ,williams4 ,9 ,may1 #aiag1 physicians 9 ! ,we/ receiv$ a lett] f ! 8,ellison-,:ite ,*autauqua ,sy/em0 in=m+ !m t ,dr4 ,h5ry ,smi? ,williams 0 to lecture at 8y\r ,*autauqua0 & rem9d+ !m t 8he has rec5tly issu$ two volumes1 #8,! ,autolys9 ,treatm5t ( ,canc]' :i* he believes w be 8 greate/ contribution to m$ical sci5ce40 ,! pres5t 8,proteal0 treatm5t appe>s to be a modification ( ! 8,autolys90 treatm5t4 ,dr4 ,williams1 9 attempt+ to ju/ify ! use ( 8 8,proteal0 9 tub]culosis1 canc]1 rheumatism1 etc41 takes advantage ( c]ta9 inve/igations be>+ on ! nonspecific reactions result+ f ! p>5tal injection ( =eign prote9s4 ,s f> z we c discov]1 !re is no sci5tific evid5ce to indicate t ! 8,proteal0 treatm5t exp\nd$ by ,williams is ( value 9 ! treatm5t ( canc]1 tub]culosis or ! o!r num]\s diseases = :i* ! 8,proteals0 are recomm5d$4 ,x is a "q :e!r su* articles z ^? on 8,! ,proteal ,treatm5t ( ,canc]10 8,new ,hope = ,rheumatism ,suff]]s10 etc41 publi%$ 9 popul> magaz9es or newspap]s s]ve any useful public purpose4 ,may !y n1 on ! contr>y1 by rais+ false hopes1 cause mu* m5tal suff]+ & d sci5tific m$ic9e great h>m8--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,july #f1 #aiah47 ,,proteog5s ,comm]cial ,!rapeutics,m ,m ,see index = additional articles on proteog5s4 ,a report ( ! ,c\ncil on ,ph>macy & ,*emi/ry t appe>s else:]e#bec 9 ?is book deals ) ano!r attempt to foi/ on our pr(ession a s]ies ( ess5tially secret prep>ations ^: !rapeutic value has n be5 sci5tifically demon/rat$4 ,grotesquely extravagant claims are advanc$ z to ! !rapeutic pot5cy & range ( action ( sub/ances ( ^: nature & effects we h no tru/wor?y in=mation4 ,physicians are advis$ to use--& _m und\bt$ly are us+--^! alleg$ rem$ies 9 ! treatm5t ( diseases 9 :i* delay 9 ! prop] k9d ( treatm5t may be ( ! greate/ dang] to ! pati5t4 ,z /at$1 !re is available no reliable in=mation reg>d+ ! effects ( ^! sub/ances :5 !y are introduc$ 9 ! human body4 ,!y may h no effect :atev]1 or !y may produce m or less direct injury2 9 ei!r case1 !re is ! *ance t damage1 ev5 irrep>able to ! pati5t1 may result because rational treatm5t is )held4 #bec ,page #bbg4 ,if we accept ! /atem5t t ! prep>ations are l>gely vegetable prote9s1 x is a fair inf]5ce t1 "u c]ta9 conditions1 !y may cause a febrile reaction ( ! same g5]al nature z t caus$ by o!r =eign prote9s :5 inject$ into ! body4 ,we "k t su* reactions are n )\t dang] & t ! treatm5t ( c]ta9 infections by induc$ reactions to =eign prote9s is /rictly an exp]im5tal proc$ure to be und]tak5 only "u v special conditions4 ,!re is1 !re=e1 no kn[n valid reason :y a physician %\ld assume ! responsibility = us+ ^! alleg$ rem$ies 9 ! treatm5t ( 8 pati5ts2 !re is a v obvi\s reason :y he %\ld n--! !rapeutic in/ructions ( 8! ,h\se ( ,m]rell1 always int]e/$ 9 ! progress ( plant !rapy0 to ! contr>y not)/&+4 ,x is ! old /ory ( exploit+ physicians ?r\gh comm]cial pseudosci5ce2 ( trad+ on ! cr$ulity ( ! pr(ession to ! detrim5t ( ! public4 ,z ,osl]#bed rec5tly prote/$ s vigor\sly3 #bed ,advance pages1 ! ,ox=d ,m$ic9e1 #aiai1 ,vol4 #a1 ,"p4 #c1 p4 #bde4 ,"s "t ago a pamphlet came f ,x & ,company1 *>act]iz$ by braz5 !rapeutic impud5ce1 & indicat+ a supreme indiff]5ce to any?+ t c\ld be call$ intellig5ce on ! "p ( ! recipi5ts4 ,t ^! firms manufactur+ ph>maci/s h ! audacity to issue su* tra% indicates ! /ate ( ?raldom 9 :i* !y reg>d u4 ,& ,i w\ld prote/ aga9/ ! usurpation on ! "p ( ^! m5 ( our function z tea*]s4 ,:y1 = example1 %\ld ,y & ,company write z if !y 7 directors ( l>ge g5ito-ur9>y cl9ics in/ead ( manufactur+ ph>maci/s8 ,x is none ( _! bus9ess :at is ! be/ treatm5t = gonorrhea--by :at possibility c\ld !y ev] "k x1 & :y %\ld _! lit]ature pret5d to ! comb9$ wisdom ( ,neiss] & ,guyon8 ,:at "r h ,z & ,company to s5d on a c>d directions = ! treatm5t ( anemia & dyspepsia1 ab\t :i* subjects !y "k z mu* z an unborn babe1 &1 if !y /ick to _! legitimate bus9ess1 ab\t ! same opportunity ( gett+ in=mation8 ,= ye>s ! pr(ession has be5 exploit$ 9 ?is way1 until ! evil has become unbe>able1 & we ne$ z active a crusade aga9/ ! pseudosci5ce 9 ! pr(ession z has be5 wag$ ( late aga9/ ! use ( quack m$ic9es by ! public4 ,we h be5 altoge!r too submissive1 & h gradually all[$ ^? :o %\ld be our will+ help]s to dictate t]ms & to play ! rle ( ma/]s4 ,,f> ,,too ,,l>ge ,a ,,section ,,( ,,! ,,treatm5t ,,( ,,disease ,,is ,,today ,,controll$ ,,by ,,! ,,big ,,manufactur+ ,,ph>maci/s1 ,,:o ,,h ,,enslav$ ,,u ,,9 ,a ,,plausible ,,pseudosci5ce4 ,:at %all ! pr(ession d to protect itself aga9/ ?is humiliation--to ?r[ (f ! cr$ulity t extols pseudosci5ce & makes comm]cializ$ empiricism f9ancially pr(itable8 ,osl] says ! rem$y is obvi\s3 8,give our /ud5ts a fir/h& acqua9tance ) disease1 & give !m a ?or\gh practical k ( ! great drugs1 & we w s5d out indep5d5t1 cle>-head$1 cauti\s practition]s :o w d _! own ?9k+ & be no long] at ! m]cy ( ! m]etrici\s lit]ature1 :i* has sapp$ our indep5d5ce40 ,excell5t6 ,b mu/ humanity wait a g5]ation8 ,:y n /op ?is evil at once8 ,! ,am]ican ,m$ical ,association has provid$ ! means :]eby ?is c be done1 if physicians w only make use ( x--! ,c\ncil on ,ph>macy & ,*emi/ry4--7,editorial f ,! ,j\rnal ,a4 ,m4 ,a41 ,july #ab1 #aiai47 ,an ,alleg$ ,endorsem5t ( ,proteog5s ,repudiat$ ,to ! ,editor3--,i note 9 ! issue ( ,! ,j\rnal = ,july #ab1 a /atem5t reg>d+ ! s-call$ 8,proteog5s0 manufactur$ by ! ,wm4 ,s4 ,m]rell ,company ( ,c9c9nati4 ,my att5tion has be5 call$ to ! fact t salesm5 ( ?is company h be5 exhibit+ a lett] purport+ to %[ t ?is dep>tm5t has endors$ _! products 9 ! treatm5t ( v5]eal diseases4 ,! lett] 9 "q 0 writt5 by a physician employ$ 9 "o ( ! cl9ics conduct$ jo9tly by ?is dep>tm5t & ! ,u4 ,s4 ,public ,heal? ,s]vice1 & ! /ation]y ( ! dep>tm5t 0 us$ )\t au?ority4 ,! physician 9 "q has made num]\s ef=ts to recall ! lett]1 b ! ,m]rell p pr(ess an inability to control its use4 ,i ne$ n add t ?is dep>tm5t has n endors$ & w n endorse ^! products1 & has no evid5ce t !y are ( any value :atsoev]4 ,all5 ,w4 ,freeman1 ,m4,d41 ,commission] ( ,heal?1 ,/ate ( ,ohio1 ,/ate ,dep>tm5t ( ,heal?4 --7,correspond5ce 9 ,! ,j\rnal ,a4 ,m4 ,a41 ,july #bf1 #aiai47 ,! ,manufactur]'s ,prote/ & a ,reply ,to ! ,editor3--,all[ u to direct y\r att5tion to sev]al mis/atem5ts :i* appe> 9 ! lett] sign$1 8,all5 ,w4 ,freeman1 ,m4,d41 ,commission] ( ,heal?1 ,/ate ( ,ohio10 publi%$ 9 ,! ,j\rnal ( ! ,am]ican ,m$ical ,association = ,july #bf4 #a4 ,salesm5 ( ?is company h n be5 exhibit+ a 8lett] purport+ to %[ t ?is dep>tm5t has endors$ _! products 9 ! treatm5t ( v5]eal diseases10 z /at$ by ,dr4 ,freeman4 #b4 ,! au?or ( ! lett] has n 8made num]\s ef=ts to recall ! lett]1 b ! ,m]rell p pr(ess an inability to control its use10 z /at$ by ,dr4 ,freeman4 ,a physician employ$ 9 "o ( ! cl9ics us$ our ,proteog5s ,nos4 #aj & #aa ext5sively & is /ill us+ !m to a l>ge ext5t 9 8 private practice4 ,he is a man ( /&+ 9 ! community 9 :i* he practices & is also a pr(essor 9 "o ( ! lead+ m$ical colleges 9 ! /ate4 ,! lett] 9 "q cites ! case ( a man :o _h be5 "u treatm5t = ?ree ye>s ) #fjf1 #iad & mo/ ( ! o!r treatm5ts 9 g5]al use1 & on ,augu/ #ca1 a ye> ago1 /ill gave a ,wass]mann te/ plus #d4 ,he 0 giv5 ,proteog5 ,no4 #aj1 & by ! middle ( ,decemb] ! ,wass]mann 0 negative & ! man 0 dis*>g$ z cur$4 ,:ile ?is lett] 0 writt5 on ! /ation]y ( ! ,bureau ( ,v5]eal ,diseases ( ! ,dep>tm5t ( ,heal?1 ,/ate ( ,ohio1 x 0 writt5 9 ! fir/ p]son1 & made no pret5sion 9 any way to be+ (ficial nor 0 any su* pret5se made or au?oriz$ by ! ,m]rell ,company4 ,! au?or ( ! lett] has n made 8num]\s ef=ts to recall ! lett]10 nor has ! ,m]rell ,company 8pr(ess$ an inability to control its use40 ,! physician did ask t ! lett] be return$ to him1 & 8 reque/ 0 compli$ ) promptly4 ,!n foll[s ! full text ( ! lett] 9 "q4 ,z its cont5ts h no be>+ on ! "q "u discussion1 x is omitt$4--,ed4 ,9 ov] n9ety-"o ye>s ( honorable s]vice z manufactur]s ( m$ic9al prep>ations1 ! ,wm4 ,s4 ,m]rell ,company has nev] endeavor$ to advance its int]e/s ?r\gh misrepres5tation4 ,! ,wm4 ,s4 ,m]rell ,company1 ,*as4 ,g4 ,m]rell1 ,pres4 ,! lett] above 0 submitt$ to ,dr4 ,all5 ,w4 ,freeman1 ,commission] ( ,heal? ( ! ,/ate ( ,ohio4 ,dr4 ,freeman's comm5ts appe> bel[4--,ed4 ,to ! ,editor3--,! pla9 issue ( v]acity rais$ 9 ! communication ( ! ,m]rell ,company mu/ be settl$ on ! evid5ce1 :i* is un=tunately too volum9\s to be publi%$ 9 full 9 ,! ,j\rnal4 ,copies ( ! correspond5ce 9 ! case h be5 furni%$ ! editor1 & ! orig9als are on file 9 ! (fice ( ! /ate dep>tm5t ( heal? 9 ,columbus4 #a4 ,:e!r or n ! photographic reproduction ( a lett] writt5 on ! lett] head ( ?is dep>tm5t1 & ! di/ribution ( copies to salesm5 = display to physicians1 0 a consci\s ef=t on ! "p ( ! firm 9 "q to create ! impression t ! lett] 0 an (ficial "o is p]haps a matt] ( inf]5ce4 ,t x did create su* an impression is evid5c$ by ! lett]s ( inquiry receiv$ f physicians :o saw x4 #b4 ,! /atem5t t ! ,m]rell ,company refus$ to return ! lett] is p]haps errone\s4 ,!y did app>5tly return ! orig9al lett] b n ! photographic copies :i* _h be5 di/ribut$ to _! salesm54 ,on ,may #bb ! firm wrote z foll[s3 8,a numb] ( physicians :o are 9 coop]ation ) bo? /ate & national bureaus ( v5]eal diseases h be5 us+ our ,proteog5s ) m>k$ success & !re are d\btless _m lett]s c>ri$ by our salesm5--reports f "s ( ^! physicians40 ,?is 0 int]pret$ to mean t ! firm _h no me?od ( kn[+ :at lett]s 7 c>ri$ by _! salesm5 & 0 n responsible = !m4 ,:e!r or n ?is int]pretation is correct is aga91 p]haps1 a matt] ( op9ion4 ,! purpose ( ! orig9al communication 0 to make pla9 to ^? ( ! pr(ession :o h already se5 or might subsequ5tly see ! lett] ref]r$ to t ! communication 0 ! expression ( an individual & n ( ! ,dep>tm5t4 ,a4 ,w4 ,freeman1 ,commission]4 --7,correspond5ce 9 ,! ,j\rnal ,a4 ,m4 ,a41 ,sept4 #f1 #aiai47 ,details ( ! ,alleg$ ,endorsem5t ( ,proteog5s ,our read]s w rememb] ! rec5t correspond5ce publi%$ 9 ,! ,j\rnal ( ,july #bf & ,septemb] #f1 by ,dr4 ,a4 ,w4 ,freeman1 ,commission] ( ,heal? ( ! ,/ate ( ,ohio & ! ,wm4 ,s4 ,m]rell ,co4 ,! lett]s dealt ) ! use t _h be5 made by ! ,wm4 ,s4 ,m]rell ,co4 ( a lett]1 writt5 on ! (ficial /ation]y ( ! ,bureau ( ,v5]eal ,diseases ( ! ,/ate ,dep>tm5t ( ,heal? ( ,ohio1 puff+ "o ( ! company's propriet>y rem$ies--,proteog5 ,no4 #aj4 ,dr4 ,freeman wrote to ,! ,j\rnal call+ ! att5tion ( ! pr(ession to ! use ( ?is lett] & expla9+ t ! lett] 0 m]ely ! expression ( op9ion ( an individual1 & n an expression f ! ,/ate ,dep>tm5t ( ,heal?4 ,! ,wm4 ,s4 ,m]rell ,co4 took exception to c]ta9 inf]5ces made 9 ,dr4 ,freeman's lett] & 9 ! c\rse ( a lett] to ,! ,j\rnal reg>d+ ?is1 incorporat$ ! cont5ts ( ! te/imonial lett]4 ,! ,j\rnal1 9 publi%+ ! ,m]rell lett]1 omitt$ ?is te/imonial on ! gr\nd t ! cont5ts ( ! lett] _h no be>+ on ! "q "u discussion4 ,we h n[ receiv$ a lett] f ! company prote/+ aga9/ ?is omission4 ,! ,j\rnal1 !re=e1 takes ?is opportunity ( briefly re/at+ su* facts z x has be5 able to get reg>d+ ! entire matt] & publi%+ ! lett]4 ,! facts are z foll[s3 #a4 ,9 ,febru>y ( ?is ye> a ,c9c9nati physician1 ,dr4 ,c4 ,j4 ,broeman1 wrote to ,dr4 ,a4 ,s4 ,horovitz relative to alleg$ results ) ,proteog5 ,no4 #aj4 ,! lett] 0 writt5--)\t au?ority--on ! (ficial /ation]y ( ! ,bureau ( ,v5]eal ,diseases ( ! ,/ate ,dep>tm5t ( ,heal? ( ,ohio4 #b4 ,! ,wm4 ,s4 ,m]rell ,co4 _h l95 m\nt$ photographs made ( ,dr4 ,broeman's lett] & di/ribut$ !m to _! ,proteog5 detail m54 ,accompany+ ^! photographic copies 0 a communication to ^! detail m5 describ+ ! photograph$ lett] z "o writt5 by3 8444 a ,c9c9nati physician :o is n[ ,act+ ,assi/ant ,surgeon1 ,u4 ,s4 ,public ,heal? ,s]vice1 coop]at+ ) ! ,bureau ( ,v5]eal ,diseases ( ! ,dep>tm5t ( ,heal? ( ! ,/ate ( ,ohio40 #c4 ,! "r h& top corn] ( ! (ficial /ation]y1 z c be se5 by ! reproduction1 bore ! "n ( 8,james ,d4 ,bauman1 ,deputy ,commission]40 ,dr4 ,broeman's signature 0 r illegible & c\ld easily be mi/ak51 by ^? n kn[+ ! h&writ+ ( ei!r man1 = ! signature ( ,deputy ,commission] ,bauman4 ,9 at lea/ "o in/ance x 0 s mi/ak51 & ! physician :o 0 misl$ wrote to ! ,director ( ! ,bureau ask+ :e!r ! te/imonial = ,proteog5 ,no4 #aj :i* _h be5 %[n him by ! ,m]rell detail man 0 really an (ficial communication4 #d4 ,on ,may #ae1 #aiai1 ,commission] ( ,heal? ,freeman wrote to ! ,m]rell ,co4 /at+ t he _h be5 in=m$ t "o ( ! ,m]rell repres5tatives 0 us+ z an adv]tisem5t a lett] be>+ ! lett]head ( ! ,bureau ( ,v5]eal ,diseases ( ! ,/ate ,dep>tm5t ( ,heal? & :at purport$ to be a report sign$ by 8,mr4 ,bauman1 ,deputy ,commission]40 #e4 ,on ,may #ai1 ! ,wm4 ,s4 ,m]rell ,co4 wrote ,dr4 ,freeman t he 0 c]ta9ly mi/ak5 9 reg>d to ! use ( any 8report sign$ by ,mr4 ,bauman40 ,dr4 ,freeman !n s5t to ! company ! lett] he _h receiv$ f ! physician :o _h mi/ak5 ,broeman's lett] = an (ficial lett] by ,bauman4 ,al?\gh x w\ld seem t ?is lett] & ,commission] ,freeman's prote/ %\ld h made pla9 to ! ,wm4 ,s4 ,m]rell ,co41 ! fact t ! lett]1 incorrectly ref]r$ to z ,mr4 ,bauman's1 0 9 reality ,dr4 ,broeman's1 ! company rema9$ sil5t reg>d+ its use ( ! ,broeman lett] &1 on ,may #bb1 m]ely reit]at$ t !re _h be5 8no lett] circulat$ by ?is company conta9+ a te/imonial ( y\r ,mr4 ,bauman40 ,on ,may #bh 7six days lat]7 ! ,m]rell company s5t to its ,proteog5 detail m5 ano!r g5]al lett]1 8= p]sonal use ( ag5ts10 9 :i* x aga9 call$ _! att5tion to ! 8photographic copy m\nt$ on l950 ( ,dr4 ,broeman's lett]4 ,?is communication to ! detail m5 also decl>$ t x 8has be5 sugge/$ t ! fur!r use ( ,dr4 ,broeman's lett] might antagonize ! ,/ate ,dep>tm5t ( ,heal?0 &1 !re=e ! detail m5 7 told to 8discont9ue us+ ! photographic copy 9 "q0 & to return ! photographs to ! head (fice4 ,illu/ration3 ,reproduction 7r$uc$7 ( "o ( ! photographic copies s5t out by ! ,wm4 ,s4 ,m]rell ,co4 to its ,proteog5 detail m5 to be %[n to physicians4 ,:ile ! lett] is a private "o1 x 0 writt5 7)\t au?ority7 on (ficial /ation]y4 ,"s physicians 7 misl$ into ?9k+ x 0 an (ficial endorsem5t ( ,proteog5s4 ,! ,m]rell conc]n d5i$ any int5tion to mislead & claim$ t x 0 int]e/$ only 9 br++ to ! att5tion ( physicians ! cont5ts ( ! lett]6 ,"h1 briefly are ! bald facts 9 ! case4 ,! ess5tial po9t at issue is :e!r ^! photographic copies ( ,dr4 ,broeman's lett] w\ld or w\ld n be likely--:e!r or n !y 7 s int5d$--to mislead physicians into believ+ t ! endorsem5t 0 an (ficial "o by ! ,/ate ,bo>d ( ,heal? r ?an an individual "o4 ,"o c b wond] :y1 if1 z ! ,m]rell company s vehem5tly ass]ts1 !re 0 no int5tion ( mislead+ physicians on ?is po9t1 ! company %\ld h gone to ! tr\ble & exp5se ( photograph+ ! entire lett]1 includ+ ! lett]head1 r ?an mak+ typewritt5 or mimeograph$ copies ( ! cont5ts ( ! lett]4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,sept4 #bg1 #aiai47 ,dr4 ,broeman's ,f9al ,report on ,proteog5s ,to ! ,editor3--,9 ! ,septemb] #bg issue ( ,! ,j\rnal my "n 0 m5tion$ 9 connection ) ! ,m]rell ,*emical ,company's 8,proteog5s0 9 ! treatm5t ( syphilis4 ,! ,m]rell ,*emical ,company promis$ n to use my "n at any "t 9 connection ) _! 8,proteog5s0 injection & !y "k t ! use ( my "n has be5 di/9ctly aga9/ my wi%es4 ,i feel t 9 ju/ice to myself1 z well z ! public1 ,i %\ld report ! result ( my exp]im5ts ) _! 8,proteog5s0 9 private practice4 ,9 explanation ,i might say t ,i began ! use ( _! 8,proteog5s0 9 ,april1 #aiah1 & ,i feel t ,i n[ h en\gh data to give a complete report4 ,i might say t all my results h be5 practically nil2 p>ticul>ly is ?is true 9 my cases ( syphilis1 :i* all _h a f\r plus ,wass]mann reaction :5 ,i discont9u$ us+ ?is =m ( treatm5t4 ,v truly y\rs1 ,c4 ,j4 ,broeman1 ,m4,d41 ,c9c9nati4 --7,correspond5ce 9 ,! ,j\rnal ,a4 ,m4 ,a41 ,oct4 #aa1 #aiai47 ,,pulvane ,9 a twelve-page pamphlet1 s5t out by ! ,pulvane ,laboratories1 ,inc41 ( ,des ,mo9es1 ,i[a1 & purport+ to deal ) 8,! ,!rapy ( ,pulvane1 an advanc$ me?od = ! treatm5t ( ,respiratory ,diseases10 we are told t ,pulvane 80 develop$ 9 a ,unit$ ,/ates ,army ,g5]al ,hospital by (fic]s ( ! ,m$ical ,dep>tm5t40 ,pulvane 8orig9ally 0 int5d$ only = its g]micidal action ^u tub]cle bacilli 9 ! lung10 b x is n[ also recomm5d$ = a/hma1 hay fev]1 bron*itis1 rh9itis1 l>yngitis & 8o!r affections ( ! air passages40 ,( ! alleg$ action ( ,pulvane on tub]culosis we read3 8,x de/roys ! spores ( ! bacilli z well z ! g]ms !mselves4 ,x prev5ts infection ( new areas by aspiration1 gravity or surface contact4 8,9 cases :]e sputum is positive x is a v notewor?y fact t %ortly aft] treatm5t is begun1 ! bacilli beg9 to disappe>1 gradually dim9i% 9 numb]1 & f9ally ! sputum becomes negative40 ,pulvane is adm9i/]$1 by inhalation1 at ! (fices ( ! ,pulvane ,laboratories1 ,inc4 ,its 8discov]]0 *anc$ on a me?od ( 8introduc+ into solution & volatiz+ a c]ta9 g]micide1 extremely r>e 9 its usage because ( its resi/ance h]et(ore to attempts to b5d x to sci5tific w40 ,?is 8r>e0 m$icam5t is alpha naph?ol6 ,b s9ce ! discov]y ( ?is volatiz+ me?od 8?ree o!r +r$i5ts ( high !rapeutic value h be5 add$40 ,:at are ^! o!r +r$i5ts8 8,!y w\ld be nam$ 7 x n t ,pulvane requires special te*nique 9 its prep>ation & adm9i/ration4 ,our m$ical directors d n consid] x advisable to id5tify !m "h because ( ! possibility ( incompet5t h&s attempt+ _! use4 ,! m$ical directors1 h[ev]1 w be glad to "n e +r$i5t ( ,pulvane = any reputable memb] ( ! pr(ession4 ,pulvane ,laboratories res]ve only ! me?od ( comp\nd+40 ,presumably1 !re=e1 if physicians desire to "k :at ,pulvane is1 ! ,pulvane ,laboratories1 ,inc41 8w be glad to "n e +r$i5t ( ,pulvane40 ,x is wor? not+ t no?+ is said ab\t quantities4 ,x is also wor? rememb]+ t 8,p]una0 & "s o!r 8pati5t m$ic9es0 h = ye>s pr9t$ on ! label ! names ( ! alleg$ +r$i5ts4 ,h[ mu* long] is ! m$ical pr(ession go+ to be fool$ ) ! trick ( no/rum exploit]s pret5d+ a frankness t means no?+8 ,f a rec5t issue ( a ,des ,mo9es newspap] we le>n t ! ,pulvane ,laboratories are ab\t to e/abli% a sanatorium :]e ! ,pulvane treatm5t c be giv54 ,?is ann\ncem5t is said to be made by ,john ,p4 ,mo%]1 ! alleg$ discov]] ( ,pulvane4 ,mo%] is n a physician4 ,! newspap] article /ates1 fur!r1 t ,mo%]'s exp]im5ts 7 tri$ out 8"u ! obs]vation ( ,major ,%>pe10 comm&] at ,=t ,des ,mo9es4 ,x appe>s also t an ex-newspap] report] is connect$ ) ! ,pulvane ,laboratories4 ,! value ( hav+ a good publicity man is obvi\sly recogniz$4 ,!re also seems to be connect$ ) ! conc]n a ,dr4 ,h>ry ,p4 ,hall4 ,we f9d 9 ! records ref]5ce to "o ,h>ry ,p4 ,hall :o 0 graduat$ by ! ,m$ical ,dep>tm5t ( ,drake ,univ]sity ( ,des ,mo9es1 ,i[a1 9 #ahid1 & 0 lic5s$ 9 ,i[a 9 #ahif4 ,our records indicate t he has n be5 9 practice = "s ye>s4 ,we also f9d 9 our files "s newspap] clipp+s reg>d+ a ,dr4 ,h>ry ,p4 ,hall :o1 9 #aiad1 plead$ guilty to a *>ge ( us+ ! mails to defraud & 0 f9$ 9 ! f$]al c\rts4 ,:e!r !re is any connection betwe5 ^! two names1 we d n "k4 ,rev]t+ to ! claims made by ! ,pulvane ,laboratories t ,pulvane 0 8develop$ 9 a ,unit$ ,/ates ,army ,g5]al ,hospital by (fic]s ( ! ,m$ical ,dep>tm5t0 ! foll[+ /atem5t has rec5tly be5 receiv$ by ,! ,j\rnal f ,surgeon-,g5]al ,irel& ( ! ,unit$ ,/ates ,army3 8,x has be5 br\ght to my att5tion t a conc]n 9 ,des ,mo9es1 ,i[a1 kn[n z ! ,pulvane ,laboratories1 has issu$ a pamphlet 9 :i* /atem5ts are made :i* w\ld naturally lead m$ical m5 to believe t ! exp]im5ts1 etc41 ref]r$ to !re9 7 made ) ! approval ( & m or less "u ! direction ( ! ,m$ical ,dep>tm5t ( ! ,army4 ,i wi% to say t ?is is n s2 t ! ,m$ical ,dep>tm5t _h no?+ :atev] to d ) ! matt] & t x ?or\ghly disapproves ( ! me?ods us$ by ! promot]s ( ?is conc]n4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,m>* #aa1 #aibb47 ,,sal ,,hepatica ,sal ,hepatica is a sal9e laxative sold by ! ,bri/ol-,my]s ,company ( ,new ,york4 ,little in=mation is giv51 or1 app>5tly1 ev] has be5 giv51 conc]n+ ! composition ( ?is product4 ,_m ye>s ago ! /ock m$ical j\rnal adv]tisem5t conta9$ ?is /atem5t3 8,composition4--,sal ,hepatica conta9s all ( ! ,tonic1 ,alt]ative & ,laxative ,salts ( ! celebrat$ #8,bitt] ,wat]s' ( ,europe1 especially ^? ( ,bohemia1 z det]m9$ by actual *emical analysis ( ^! wat]s1 & =tifi$ by ! addition ( ,li?ium & ,sodium ,phosphates40#bee #bee ,"s ( ! ,sal ,hepatica adv]tis+ has claim$ t x 8is a sal9e comb9ation ) ! addition ( ,sodium ,phosphate & ,li?ia ,citrate60 ,sal ,hepatica no long] 8conta9s all ! tonic1 alt]ative & laxative salts 44410 etc41 = ! label on a package rec5tly pur*as$ reads3 8,,sal ,,hepatica is an eff]vesc5t sal9e comb9ation possess+ m$ic9al prop]ties simil> to ! natural #8,bitt] ,wat]s' ( ,europe1 & =tifi$ by ! addition ( ,sodium ,phosphate40 ,9 #aiji1 ! ,druggi/s ,circul> publi%$ an analysis ( ,sal ,hepatica :i* %[$ t ! prep>ation conta9$ only #j4jd p] c5t4 ( li?ium phosphate4 ,by ref]r+ to ! two quotations j giv5 x w be notic$ t today ! manufactur]s make no claim t _! prep>ation is =tifi$ ) any salt ( li?ium4 ,a circul> accompany+ rec5t trade packages /ates3 8,sal ,hepatica is compos$ solely ( h>mless salts1 be+ absolutely free f ,acetanilid1 ,ph5acet91 ,caffe91 ,calomel1 opium or coal t> d]ivatives40 ,s9ce nei!r ! names nor ! am\nts ( ! 8h>mless salts0 are m5tion$1 ! composition ( ,sal ,hepatica is secret4 ,x is a trick ( ! no/rum exploit]1 old b ev] popul>1 to m5tion num]\s drugs :i* 8 prep>ation does n conta92 x helps to di/ract att5tion f ! fact t he does n tell :at ! prep>ation does conta96 ,9 ! old-"t m$ical j\rnal adv]tisem5ts1 "o reads1 8,sal ,hepatica is ! mo/ p[]ful solv5t ( ,uric ,acid kn[n40 7,! same adv]tisem5t z x appe>$ 9 ^? days 9 ,! ,j\rnal %[s t claim ton$ d[n to1 8,sal ,hepatica is a p[]ful solv5t ( ,uric ,acid407 ,9 ^? easy go+ days1 ! ,bri/ol-,my]s ,company decl>$ t 8diabetes is treat$ ) decid$ advantage by means ( ,sal ,hepatica 444 x 444 possesses ! prop]ty ( arre/+ ! secretion ( sug> 9 ! liv]40 ,9 ! old days1 too1 ,sal ,hepatica 0 recomm5d$ 9 ! treatm5t ( cirrhosis ( ! liv]1 ,bright's disease1 gravel1 ph?isis1 etc4 ,! pres5t adv]tis+ circul> recomm5ds ,sal ,hepatica z an elim9ant1 laxative or ca?>tic 9 g\t1 auto9toxication1 8,bili\s ,attacks10 rheumatism1 acute indige/ion1 cat>rhal conditions ( ! /oma*1 pyorrhea1 heada*e1 dizz9ess1 he>t burn1 8,summ] ,compla9ts10 8,d]angem5ts ( ! ,/oma* & ,liv]10 sk9 diseases1 colic1 alcoholic excesses1 & z a 8prev5tive ( ,seasickness40 ,9 #aiad ! ,c\ncil on ,ph>macy & ,*emi/ry publi%$#bef a report on ,sal ,hepatica decl>+ x secret 9 composition & sold "u exagg]at$ & unw>rant$ claims4 #bef ,j4 ,a4 ,m4 ,a41 ,feb4 #g1 #aiad1 p4 #dgb4 ,9 view ( ! inquiries :i* ,! ,j\rnal cont9ues to receive x seem$ wor? :ile to make a *emical exam9ation ( ! pres5t-day product4 ,accord+ly specim5s 7 pur*as$ & analyz$ 9 ! ,a4 ,m4 ,a4 ,*emical ,laboratory4 ,! report t foll[s 0 submitt$ by ! *emi/s3 8,sal ,hepatica is a :ite1 granul>1 odorless p[d]4 ,x eff]vesces on ! addition ( wat] 9 :i* x ev5tually dissolves4 ,! aque\s solution1 aft] boil+ to remove c>bon dioxid1 has an acid reaction to litmus4 8,s9ce a great _m m$ic9al sub/ances are sold 9 eff]vesc5t =m1 & s9ce practically no in=mation is giv5 by ! manufactur] conc]n+ ! composition ( ,sal ,hepatica1 x became necess>y to te/ = a consid]able numb] ( !rapeutic ag5ts4 ,! abs5ce ( acetanilid1 acetph5etid91 alkaloids1 ammonium salts1 b5zoates1 caffe91 citrates1 heavy metals1 hexame?yl5am91 magnesium1 potassium1 salicylates & sug>s 0 demon/rat$ by appropriate te/s4 ,! pres5ce ( a c>bonate 7probably 9 ! =m ( a bic>bonate71 a phosphate1 a sulphate1 a *lorid1 t>t>ic acid1 sodium & traces ( li?ium 0 %[n by qualitative te/s4 8,quantitative analysis indicat$ t ! composition ( ! specim5s exam9$ 0 ess5tially z foll[s3 ,sodium phosphate1 anhydr\s #d4d p] c5t4 ,sodium sulphate1 anhydr\s #bf4e p] c5t4 ,sodium t>trate1 anhydr\s #ab4g p] c5t4 ,sodium bic>bonate #ai4e p] c5t4 ,t>t>ic ,acid1 free #bj4h p] c5t4 ,sodium *lorid #h4i p] c5t4 ,li?ium phosphate trace ,wat] ( hydration 7by diff]5ce7 #g4b p] c5t4 8,f ! results ( ! analysis1 x appe>s probable t ! composition ( ! mixture be=e #8granulation' 0 approximately z foll[s3 ,sodium phosphate #d p] c5t4 ,sodium sulphate #be p] c5t4 ,sodium bic>bonate #cj p] c5t4 ,t>t>ic ,acid #cj p] c5t4 ,sodium *lorid #h p] c5t4 ,li?ium phosphate trace ,wat] ( hydration 7by diff]5ce7 #c p] c5t4 8,sal ,hepatica1 !re=e1 is ess5tially an eff]vesc+ mixture ( dri$ sodium sulphate 7,glaub]'s salt7 & sodium t>trate ) a little dri$ sodium phosphate & table salt add$4 ,x is simil> to ! eff]vesc5t artificial ,c>lsbad ,salt describ$ 9 ! ,national ,=mul>y4 8,9 #aiji ! ,druggi/s ,circul> publi%$ ! foll[+ analysis ( ,sal ,hepatica3 ,sodium phosphate #bi4hj p>ts ,sodium sulphate 7,glaub]'s salt7 #bf4bg p>ts ,sodium bic>bonate 7bak+ soda7 #ah4jj p>ts ,sodium *lorid 7salt7 #ac4je p>ts ,li?ium phosphate #j4jd p>ts ,citric & t>t>ic acids 7to make #ajj7 #ab4hd p>ts 8,a comp>ison ( ! rec5t analysis ) ! e>li] "o w\ld seem to indicate t consid]able *anges h be5 made 9 ! =mula s9ce ! fir/ exam9ation4 ,! proportions ( sodium phosphate h be5 greatly r$uc$1 :ile ! sodium bic>bonate & t>t>ic acid h be5 increas$ & ! citric acid entirely elim9at$40 ,sal ,hepatica1 !n1 is a simple eff]vesc5t sal9e laxative1 ess5tially secret 9 composition & sold "u claims t w\ld be laugh$ at 7 ! full =mula ( ! product a matt] ( public k4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,oct4 #bi1 #aiba47 ,,salicon 8,salicon0 is m>ket$ by ! ,k4 ,a4 ,hughes ,company1 ,bo/on1 z 8an improv$ aspir940 ,9 a circul> s5t out to ! public a little ov] a ye> ago ! foll[+ claims 7 made = x3 8,we r5d]$ aspir9 absolutely h>mless & yet reta9$ all its virtues z a m$ic9e40 8,x positively w n depress ! he>t nor upset ! /oma* no matt] h[ l>ge am\nts ( x are tak540 8444 ! ,massa*usetts /ate m$ical au?orities 444 adopt$ its use at all ! /ate camps = fight+ ! ,spani% influ5za44440 ,! fir/ two /atem5ts quot$ above are obvi\sly false4 ,! ?ird /atem5t might h be5 true al?\gh x seem$ unlikely4 ,a lett] 01 !re=e1 writt5 to ! ,dep>tm5t ( ,public ,heal? ( ! ,commonweal? ( ,massa*usetts & ! claim ( ! ,k4 ,a4 ,hughes ,company relative to ! adoption ( ,salicon 9 all ! /ate camps by ! 8/ate m$ical au?orities0 0 br\ght to _! att5tion4 ,! reply ( ! dep>tm5t on ?is po9t 0 emphatic3 8,! ,/ate ,dep>tm5t ( ,heal? ( ,massa*usetts did n endorse ! use ( ,salicon = any purpose40 ,"s ,salicon 0 pur*as$ on ! op5 m>ket & submitt$ to ! ,a4 ,m4 ,a4 ,*emical ,laboratory = analysis4 ,"h is ! *emi/s' report4 8,"o orig9al bottle ( #8,salicon' 7,k4 ,a4 ,hughes ,company1 ,bo/on7 0 submitt$ by ! ,propag&a dep>tm5t ( ,! ,j\rnal to ! ,association's ,*emical ,laboratory = exam9ation4 ,! bottle conta9$ #ajj :ite tablets hav+ an av]age weight ( #j4djg gram 7#f4c gra9s71 ea*4 ,! am\nt ( a% 0 #bj4i p] c5t4 ,qualitative te/s indicat$ ! pres5ce ( magnesium1 c>bonate1 />*1 acetylsalicylic acid & a trace ( calcium2 a v small am\nt ( a petrolatum-l sub/ance 0 pres5t4 ,alkaloids & drugs us$ = a laxative effect 7 n f\nd4 ,! am\nt ( acetylsalicylic acid extract$ by *lor(orm 0 #ej4g p] c5t4 ,! am\nt ( magnesium pres5t z magnesium oxid 0 #ad4c p] c5t4 ,! am\nt ( magnesium oxid d]iv$ f magnesium c>bonate ,u4 ,s4 ,p4 is v>iable2 b calculat+ on ! l[e/ limit1 #ad4c p] c5t4 ( magnesium oxid is equival5t to at lea/ #ce4e p] c5t4 ( magnesium c>bonate4 ,?is figure agre$ closely ) t obta9$ f ! ,u4 ,s4 ,p41 me?od ( assay4 ,! acetylsalicylic acid 0 n comb9$ ) ! magnesium4 ,f ! above1 x may be /at$ t ea* tablet consi/$ ess5tially ( a mixture ( #c4b gra9s ( acetylsalicylic acid 7aspir971 #b4b gra9s ( magnesium c>bonate & "s />*4 ,al?\gh label$ #e gra9s1 ea* tablet did n conta9 #e gra9s ( ! mo/ active +r$i5t1 acetylsalicylic acid40 ,! same old /ory4 ,an ord9>y mixture ( well kn[n drugs put on ! m>ket z a new discov]y & foi/$ on ! public "u false & mislead+ claims4--7,correspond5ce 9 ,! ,j\rnal ,a4 ,m4 ,a41 ,feb4 #e1 #aiba47 ,,s-,,call$ ,,secret9 ,,prep>ations ,9 ,*9a ! adm9i/ration ( p[d]$ tig]-bone is--or 0--a favorite =m ( treatm5t 9 cases ( suppos$ c>diac weakness4 ,! !ory is1 presumably1 t ! c>diac /r5g? ( ! tig] w\ld be a good ?+ = ! pati5t to acquire4 ,s9ce _m pati5ts h recov]$ aft] tak+ tig]-bone1 & no "o has prov$ t !y might n h di$ _h !y fail$ to take x1 8cl9ical exp]i5ce0 /&s back ( ! treatm5t2 & :]e is ! skeptic s ra% z to *all5ge t8 ,! ,*9ese physician believes 9 8 tig]-bone !rapy1 &1 ) ! be/ int]e/s ( 8 pati5t at he>t1 insi/s on obta9+ absolutely true & au!ntic tig]-bone4 ,n satisfi$ ) ! ass]tions ( ! deal]s1 ! consci5ti\s ,*9ese physician subjects 8 tig]-bone to a k9d ( physiologic /&>dization4 ,he (f]s ! bone 9 "q to a dog6 ,if x is an ox-bone--a frequ5t =m ( sub/itution--! dog w seize & eag]ly gnaw x1 :]eas1 accord+ to all ! tea*+s ( ,*9ese ph>macognosy1 if x is a tig]-bone ! dog w dep>t hurri$ly ) 8 tail betwe5 8 legs4 ,v fooli%8 ,yes6 ,b be=e we smile sup]cili\sly at ! ,*9ese m$ical man1 let u turn to ! report ( ! ,c\ncil on ,ph>macy & ,*emi/ry on 8,s-,call$ ,secret9 ,prep>ations40#beg ,aft] read+ ?is report let u put to ourselves1 squ>ely & hone/ly1 ! "q3 ,has ! attitude t[>d secret9 !rapy1 ( a c]ta9 portion ( ^? :o repres5t ,we/]n mod]n m$ic9e1 really be5 mu* m sci5tific ?an t ( ! ,*9ese m$ical pr(ession t[>d tig]-bone !rapy8 ,on ! basis ( a hypo!sis sc>cely less crude & unsub/antiat$ ?an t :i* assumes t tig]-bone is ( value 9 he>t disease1 x has be5 assum$ t secret9 is ( value 9 ga/ro-inte/9al diseases4 ,on ! gr\nd ( 8cl9ical evid5ce0 sc>cely m critical ?an t exhibit$ by our confrres 9 ! antipodes1 x has be5 ass]t$ t alleg$ secret9 prep>ations actually are effici\s4 ,inde$1 9 "o respect ! me?ods ( ! ,*9ese physician appe> m sci5tific ?an ^? ( 8 ,we/]n bre?r54 ,to ! be/ ( 8 ability1 ! ,ori5tal at lea/ makes sure t he is adm9i/]+ g5u9e tig]-bone2 he does n rely on ! unv]ifi$ ^w ( 8 deal] alone4 ,! ,am]ican physician has n be5 mak+ ! lea/ ef=t to asc]ta9 :e!r 8 suppos$ secret9 prep>ations are truly su*2 &1 z a matt] ( fact1 sci5tific inve/igation seems to indicate t "s ( ^! products conta9$ no secret9 at all6 ,:atev] "o may ?9k ( ! validity ( 8 te/1 ! ,*9ese physician does 8 be/ accord+ to 8 lights4 ,z to 8cl9ical exp]i5ce10 ,dr4 ,jacobi has well said t "s p make ! same mi/ake a hundr$ times & call x 8exp]i5ce40--7,editorial f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #ae1 #aiaf47 #beg ,page #fd4 ,,succus ,,c9]>ia ,,m>itima ,ano!r ,illu/ration ( ,"o ( ! ,weaknesses ( ! ,f$]al ,food & ,drugs ,act ,! ,walk] ,ph>macal ,company ( ,/4 ,l\is 01 we und]/&1 if x is n /ill1 "o ( ! subsidi>y conc]ns ( ! ,luyties ,homeopa?ic ,ph>macy ,company4 ,x has = ye>s sold a no/rum1 8,succus ,c9]>ia ,m>itima10 "u ! claim t by simply dropp+ ?is /uff into ! eye1 twice daily1 cat>act & o!r opacities ( ! eye w be cur$4 ,= in/ance3 8444 ! only rem$y = ! relief ( cat>act & o!r opacities ( vision1 :i* /&s be=e ! m$ical frat]nity on a firm f\ndation ( accompli%$ results44440 8444 possesses a specific p[] 9 remov+ ! ob/ruction to vision40 8,9 ?is class ( cases cat>act physicians c place reliance on ,succus ,c9]>ia ,m>itima 7,walk]7 :i* does n require ! s]vices ( a speciali/ b is simply dropp$ into ! eye ) an ord9>y m$ic9e dropp] twice daily44440 8444 has be5 us$ ) success 9 cat>act1 bo? l5ticul> & capsul>1 pt]ygium & opacities ( ! cornea1 s(t5+ ! opaque deposits1 caus+ dissolution1 & by its /imulat+ prop]ties1 ha/5+ absorption40 ,succus ,c9]>ia ,m>itima is adv]tis$ to ! m$ical pr(ession 9 true 8pat5t m$ic9e0 /yle by means ( te/imonials f doctors1 obscure & deceas$4 ,! prep>ation is valueless = ! purposes = :i* x is sold & 8has ab\t z mu* effect on ! dissolution or disp]sal ( opacities due to organic *anges 9 ! l5s z p\r+ ! same d[n ! back ( ! pati5t's neck60 ,m ?an five ye>s ago ! ,c\ncil on ,ph>macy & ,*emi/ry report$ on ! wor?lessness ( ! drug1 ,c9]>ia m>itima1 &1 at ! same "t1 ,! ,j\rnal po9t$ out t ! drug w\ld h be5 =gott5 long ago _h x n be5 = ! prodigal use ( pr9t]s' ink by ! ,walk] ,ph>macal ,company 9 adv]tis+ its ,succus ,c9]>ia ,m>itima4 ,^! facts are giv5 = ! purpose ( refre%+ ! memory ( our read]s & are b incid5tal to ! object ( ?is article4 ,9 due "t ! f$]al au?orities proce$$ aga9/ ! ,walk] ,ph>macal ,company *>g+ t ,succus ,c9]>ia ,m>itima 0 misbr&$ "u ! f$]al ,food & ,drugs ,act4 ,! gov]nm5t *emi/s report$ t analysis 8%[$ t ! product 0 ess5tially an aque\s solution ( glyc]91 boric acid & vegetable drug extractives c>ry+ tann9-l bodies40 ,! direct & inf]5tial claims made 9 ! adv]tis+ matt] accompany+ ! trade package 7 quot$ by ! f$]al au?orities1 :o po9t$ out t ! ,walk] ,ph>macal ,company 0 sell+ ! no/rum "u claims t w\ld create 9 ! m9ds ( ! pur*as]s ! belief t ,succus ,c9]>ia ,m>itima 0 a rem$y = cat>act & o!r opacities ( ! eye caus+ impair$ vision & t x 0 a cure = s5ile cat>act1 tra*oma1 second>y opacities1 etc4 ,^! claims ! gov]nm5t *>g$ 7 8false & fraudul5t 9 t ! same 7 appli$ to ! article kn[+ly1 & 9 reckless & wanton disreg>d ( _! tru? or falsity10 because 89 tru? & 9 fact x 0 n1 9 :ole or 9 "p1 compos$ (1 & did n conta91 su* +r$i5ts & m$ic9al ag5ts0 z w\ld produce ! !rapeutic effects claim$4 ,illu/ration3 ,facsimile ( a lett]1 dat$ ,octob]1 #aiaf1 sugge/+ ! use ( 8,succus ,c9]>ia ,m>itima0 z a cure = cat>act & o!r opacities ( vision4 ,eight mon?s previ\sly 7,febru>y1 #aiaf71 ! ,walk] ,ph>macal ,company _h plead$ guilty to ! *>ge t ! claims t 8,succus ,c9]>ia ,m>itima0 0 a cure = cat>act & o!r eye opacities 7 false & fraudul5t & appli$ kn[+ly & 9 reckless & wanton disreg>d ( _! tru? or falsity4 ,! f$]al ,food & ,drugs ,act does n apply to claims made 9 circul> lett]s or else:]e ?an 9 ! trade package4 ,^! *>ges put ! matt] flatly up to ! ,walk] ,ph>macal ,company4 ,?is company has = ye>s be5 tell+ physicians t _! /uff c\ld & w\ld d j :at ! f$]al au?orities insi/$ x c n & w n d4 ,did ! ,walk] ,ph>macal ,company attempt to def5d its claims8 ,did x demon/rate t ,succus ,c9]>ia ,m>itima w\ld cure cat>act8 ,did x produce evid5ce ( ! num]\s cases ( recov]y f bl9dness or p>tial bl9dness :i* mu/ h be5 available if ! prep>ation _h ! p[]s claim$ = x8 ,no6 ,! ,walk] ,ph>macal ,company 9 ,febru>y1 #aiaf1 plead$ guilty--& 0 f9$ a paltry #aj & co/s4 ,?is1 h[ev]1 is n ! end ( ! /ory4 ,! company 0 prosecut$ because x _h publi%$ ! false & fraudul5t claims 9 ! trade package1 ?us br++ ! claims )9 ! purview ( ! f$]al ,food & ,drugs ,act4 ,_h ! ,walk] ,ph>macal ,company conf9$ its false /atem5ts to m$ical j\rnal adv]tisem5ts1 to ! circul> lett]s s5t to physicians or to any o!r adv]tis+ matt] n "p ( ! trade package1 x c\ld h snapp$ its f+]s at ! ,food & ,drugs ,act4 ,x 0 9 ,febru>y1 #aiaf1 t ! ,walk] ,ph>macal ,company plead$ guilty to ! *>ge ( mak+ false & fraudul5t claims = ,succus ,c9]>ia ,m>itima4 ,9 ,octob]1 #aiaf1 !y 7 /ill s5d+ out circul> lett]s to physicians urg+ ! use ( ,succus ,c9]>ia ,m>itima 9 ! treatm5t ( cat>act & enclos+ ! usual booklet ( te/imonials claim+ cures = cat>act & o!r opacities ( ! l5s & cornea6 ,illu/ration3 ,facsimile ( "s ( ! pages f ! booklet t accompani$ ! lett] reproduc$ h]e)4 ,! obvi\s int5t ( ?is booklet 0 to lead physicians to believe t ,succus ,c9]>ia ,m>itima w cure 8,opacity ( ! ,cornea10 8,opacity ( ! ,l5s10 8,s5ile ,cat>act10 8,incipi5t ,cat>act10 8,d\ble ,cat>act10 etc4 ,c "o conceive a bett] illu/ration ( ! inadequacy ( ! ,food & ,drugs ,act8 ,! di%one/ exploit] ( propriet>y m$ic9es c>es little t ! law requires him to keep )9 c]ta9 b\nds ( tru?fulness 9 ! adv]tis+ t accompanies ! trade package4 ,x isn't ! claims 9 ! trade packages t sell ! product2 x's ! adv]tis+ 9 m$ical j\rnals1 9 circul> lett]s1 etc4 ,yet1 ! ,food & ,drugs ,act (f]s no *eck or curb on false /atem5ts or fraudul5t claims made = propriet>y or 8pat5t m$ic9es0 9 any o!r place ?an ! trade packages4 ,a few weeks ago ,! ,j\rnal call$ att5tion to a flagrant case ( fraud2 & at t "t x said1 8,x is ju/ifiable to assume t :5 any man1 :atev] 8 bus9ess1 admits 9 c\rt t he has made fraudul5t claims & !n cont9ues to make ! same claims ?r\gh *annels t are n controll$ by p5al enactm5t1 t man's /&>d ( bus9ess e?ics is su* t ! public ne$s protection aga9/ x4 ,!re are _m su* m5 9 ! #8pat5t m$ic9e' _w4 ,! only way 9 :i* ! public may prop]ly be protect$ aga9/ be+ defraud$ 9 su* cases is = ! f$]al ,food & ,drugs ,act to h its scope ext5d$ to cov] all adv]tis+ ( ! products com+ "u ! purview ( ! act40--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,m>* #ag1 #aiag47 ,,tek>k9 ,edw>d ,p]cy ,rob9son's 8,cure0 = ,canc] ,f v>i\s p>ts ( ! c\ntry ,! ,j\rnal has receiv$ a sixte5 page pamphlet1 ,!rapeutic ,leaves4 ,! publication1 :i* has a saffron color$ cov]1 is said to be publi%$ by ! ,national ,bio-,*emical ,laboratory1 ,m\nt ,v]non1 ,n4 ,y4 ,! ,national ,bio-,*emical ,laboratory seems to be a /yle us$ by ,dr4 ,edw>d ,p]cy ,rob9son4 ,! 8editorial (fices0 ( ,!rapeutic ,leaves are giv5 z 8#eja ,knox ,bldg41 #e? ,ave4 at #dj? ,/41 ,new ,york10 :i* is a r\ndab\t way ( describ+ #deb ,fif? ,ave41 ! (fice address ( ,edw>d ,p]cy ,rob9son4 ,! fir/ numb] 7,febru>y1 #aiba7 ( ,!rapeutic ,leaves gives ! names ( ! 8editors0 z 8,e4 ,p4 ,rob9son1 ,m4,d41 & ,w4 ,a4 ,j5n]1 ,b4,a40 ,9 addition1 !re is 8,assi/ant ,editor1 ,f4 ,j4 ,geig]10 & 8,g5'l ,manag]1 ,bev]ly ,k4 ,rob9son40 ,! fir/ & second numb]s ( ,!rapeutic ,leaves 7,febru>y & ,m>*1 #aiba7 are practically id5tical1 be+ evid5tly pr9t$ f ! same plates4 ,!rapeutic ,leaves purports to be a p]iodical publi%$ z 8a m$ium = ! dissem9ation ( k1 p]ta9+ to !rapeusis40 ,actually1 x is an adv]tis+ m$ium deal+ ) ! products ( ! ,national ,bio-,*emical ,laboratory3 8,osmo-,calcic ,solution10 8,tek>k90 & 8,osmotic ,mangano-,potassic ,solution40 ,^! prep>ations are said to be ! 8=mulas0 ( ,dr4 ,edw>d ,p]cy ,rob9son :o lives 9 ,mt4 ,v]non1 ,n4 ,y41 & has an (fice at #deb ,fif? ,ave41 ,new ,york ,city4 ,!y are us$ by ,dr4 ,rob9son 9 ! treatm5t ( canc]4 ,at an e>li] /age !y seem to h be5 kn[n "u diff]5t names3 8,tek>k90 0 fir/ 8,hypotonic ,sal-,cella0 & !n 8,neoanabol9-,x20 8,osmo-,calcic ,solution0 0 8,osmotonic ,calcic0 :ile 8,osmotic ,mangano-,potassic ,solution0 0 8,osmotonic ,drops40 ,! ?ree solutions are put up 9 "o package conta9+ #d c4c4 7ab\t #fe m9ims7 ( 8,tek>k90 & #a ounce ea* ( ! o!r prep>ations4 ,! package sells = #aj4jj4 8,remittance ) ord] 444 ,we h no ag5ts40 ,illu/ration ,mo/ ( ! mat]ial 9 ,!rapeutic ,leaves is a reha% ( f\r pap]s publi%$ by ,edw>d ,p]cy ,rob9son 9 ! ,new ,york ,m$ical ,record ( v>i\s dates betwe5 ,septemb]1 #aiag1 & ,july1 #aibj4 ,9 ^! ,rob9son advances ! !ory t canc] is caus$ by an excess ( sodium *lorid 7table salt7 9 ! blood & tissues & t x c be cur$ by adm9i/]+ a solution ( potassium nitrate4 ,su* a treatm5t s\nds ideally simple4 ,"o might assume t all t 0 necess>y 0 to make up a solution ( potassium nitrate & inject x4 ,"o might fur!r wond] h[ x w\ld be possible to comm]cialize su* a 8treatm5t40 8,homemade solutions10 says ,dr4 ,rob9son1 8are apt to be disappo9t+40 ,_! use is likely to cause 8consid]able swell+ at ! site ( an injection1 accompani$ ) t5d]ness & "s heat40 ,moreov]1 8a wide hyp]emic area ) r$ blot*es has be5 obs]v$ 9 a numb] ( in/ances40 ,9 ord] to avoid 8accid5ts ( ?is sort0 :i* w\ld 8br+ discr$it ^u an excell5t ag5t10 ,dr4 ,rob9son1 8aft] consid]able exp]im5tal "w0 has obta9$ 8a solution ( ?is *emical :i* w\ld meet ! ideal requirem5ts40 ,?is is available "u ! "n 8,tek>k940 ,dilute potassium nitrate solution sold "u ! "n 8,tek>k90 sells = #fg an ounce4 ,! physician c make 8 own solution1 ( ! pure/ & highe/ grade potassium nitrate on ! m>ket1 at an exp5se1 = ! *emical1 n exce$+ #e c5ts an ounce4 ,!rapeutic ,leaves also conta9s ! usual numb] ( ^? 8cl9ical reports0 :i* bulk s l>ge 9 ! lit]ature ( 8cures0 = canc]4 ,!n !re is a full page adv]tisem5t ( a side-l9e ( ! ,national ,bio-,*emical ,laboratory3 8,vitam9es 7,compress$7 ,tek>k9 ,br&20 8,!y h a meaty ta/e40 ,! m$ical pr(ession1 naturally1 is int]e/$ 9 kn[+ m ab\t ! physician :o admits t he has discov]$ ! cause & cure ( canc]4 ,accord+ to our records1 ,edw>d ,p]cy ,rob9son 0 born 9 #ahga & 0 graduat$ 9 #ahig by ,bellevue ,hospital ,m$ical ,college4 ,he 0 lic5s$ 9 ,new ,york ,/ate ! same ye> & has practic$ 9 ,new ,york ,city cont9u\sly s9ce t "t4 ,he is n1 & app>5tly nev] has be51 a memb] ( 8 local m$ical society4 ,9 #aiad ,rob9son 0 specializ+ 9 8facial cont\r+40 ,"o piece ( adv]tis+ purports to be ! repr9t ( an int]view ) 8,dr4 ,e4 ,p4 ,rob9son1 ,speciali/1 z he sat 9 8 (fice at #aaf ,we/ #ci? ,/reet1 hav+ que/ions fir$ at him by ! report]40 ,?us ,dr4 ,rob9son3 8,!re are physicians ev]y:]e :o ab&on ! g5]al1 or family1 practice ( m$ic9e1 to devote _! life to "s specialty4 ,my specialty is ! improvem5t ( ! facial features & ! beautify+ ( ! %\ld]s1 neck & arms4 ,i r\nd out holl[ *eeks1 build up ! neck1 eradicate wr9kles1 make irregul> noses p]fect & remove defects by a process :i* is my own secret4 ,i claim no sup]human p[] or ability2 ,i h simply b5t my :ole pr(essional /udy & en]gy to ! "o l9e ( remodel+--s to speak--! human features1 & ,i employ only sci5tific me?ods & aids 9 my op]ations40 ,9 ano!r piece ( adv]tis+1 a little booklet be>+ ,edw>d ,p]cy ,rob9son's "n1 we f9d ! foll[+3 8,?is is :at ,i accompli%4444 8,remove all wr9kles & traces ( age f ! =ehead1 or ab\t ! eyes & m\?4 ,lift sag f *eeks & *94 8,r\nd out holl[ *eeks4 8,remove depressions & defects f ! *94 8,build up ! neck & %\ld]s4 8,build up & enl>ge ! bu/4 8,r\nd out & give symmetry to un%apely arms & remove ! l9es ( age f ! h&s4 8,correct _m ( ! defects n m5tion$ "h1 b :i* may be possess$ by exceptional cases40 ,illu/ration3 ,reproduction 7r$uc$7 ( "s adv]tis+ matt] issu$ 9 #aiad :5 ,edw>d ,p]cy ,rob9son 0 specializ+ 9 8facial cont\r+40 ,/ill ano!r adv]tis+ leaflet purports to be a repr9t ( an 8editorial0 f ! ,m]cantile & ,f9ancial ,times ( ,m>* #aa1 #aiad4 ,x is a pret5ti\s puff ( ,rob9son1 tell+ ab\t 8 8sci5tific atta9m5ts0 & 8 m>vel\s secret prep>ations us$ 9 8,y\?ify+ ! ,face40 ,! ,m]cantile & ,f9ancial ,times is an utt]ly discr$it$ %eet run = ! purpose ( sell+ :at appe> to be editorial comm5ts4 ,su* 8editorial0 puffs are paid = ?r\gh ! pur*ase ( a c]ta9 numb] ( copies ( ! pap] by ! p>ty :o desires ! publicity4 ,! ,associat$ ,adv]tis+ ,clubs ( ! ,_w expos$ ?is publication 9 a special bullet9 issu$ 9 ,june1 #aiai1 & describ$ x z an 8example ( publications t s]ve z conv5i5t tools ( fake promot]s40 ,9 #aiaa ! ,m]cantile & ,f9ancial ,times publi%$ an 8editorial0 endorsem5t ( ! consumption cure 8,nature's ,creation40 ,x has done ! same = a faki% device kn[n z ! 8,ideal ,sight ,re/or]40 ,x publi%$ a puff on ! 8,oxypa?or10 a sw9dle s prepo/]\s t ! exploitation ( ?is 8gaspipe0 fake 0 deb>r$ f ! ,u4 ,s4 mails & its exploit] 0 s5t to ! f$]al p5it5ti>y4 ,illu/ration3 - - - - - - - - - - - - - - - - - - - ,! ,jean ,d[ns ,co41 ,new ,york ,my de> ,mrs4 ,d[ns1 ,! package ( y\r 8,get ,slim0 rem$y = obesity has be5 giv5 to a pati5t ( m9e ) b5eficial results4 ,9 obs]v+ ! action ( ! rem$y ,i not$ no laxative effect on ! b[els1 or any di/urbance ( ! /oma*4 ,9 fact !re 7 no physical s5sations t any rem$y _h be5 tak51 & !re 0 a v satisfactory r$uction 9 weight4 8,get ,slim0 rem$y1 be+ a purely vegetable comb9ation is n fraught ) any risk to ! individual's heal?1 & may be safely giv54 ,i w\ld n hesitate to prescribe x = a *ild suff]+ f obesity4 ,?is /atem5t is bas$ on ! fact t ,i am acqua9t$ ) ! +r$i5ts ent]+ into its manufacture4 ,i w\ld add t ?is rem$y = obesity might be intro- duc$ to ! regul> physicians ) "s advantage to y4 ,y\rs truly1 ,e ,p ,,rob9son ,m ,d #adjb ,broadway ---------------------------------------- ------------------- ,reproduction 7r$uc$7 ( a te/imonial = an obesity cure fake1 8,get ,slim40 ,! ,a4 ,m4 ,a4 *emi/s report$ t ?is 8vegetable comb9ation0 consi/$ ( bak+ soda & p9k-t9t$ t>t>ic acid & sug>4 ,we also f9d 9 our files a te/imonial sign$ ,e4 ,p4 ,rob9son1 ,m4,d41 #adjb ,broadway 7,edw>d ,p]cy ,rob9son's address 9 #aiab71 extoll+ ! virtues ( a fooli% piece ( quack]y1 ! obesity cure 8,get ,slim40 ,?is no/rum 0 expos$ 9 ,! ,j\rnal "s ye>s ago & 0 also expos$ by ,dr4 ,wiley 9 ,good ,h\sekeep+4 ,! 8,get ,slim0 conc]n su$ ,good ,h\sekeep+ = libel b a jury decid$ t ,good ,h\sekeep+ _h told ! tru?4 ,9 ! 8,get ,slim0 te/imonial ,rob9son is quot$ z say+ t he is 8acqua9t$ ) ! +r$i5ts ent]+ into its manufacture0 & he describes x1 z did ! 8,get ,slim0 conc]n1 z 8a purely vegetable comb9ation40 ,! fact is ! ,association's *emi/s f\nd ?is 8purely vegetable comb9ation0 to consi/ ( sug> & t>t>ic acid1 ea* color$ p9k1 & bak+ soda4 ,& ?is is ! g5tleman :o claims to h discov]$ ! cause (1 & (f]s = sale a cure =1 "o ( ! mo/ baffl+ sc\rges kn[n to mod]n m$ic9e--canc]4 ,except = ! articles t h be5 publi%$ dur+ ! pa/ ?ree ye>s 9 ! ,m$ical ,record1 we are unable to f9d any:]e 9 repres5tative m$ical lit]ature any?+ to indicate t ,edw>d ,p]cy ,rob9son c lay any claim to special k (1 or skill 9 ! treatm5t (1 canc]4 ,:at we d f9d are adv]tisem5ts describ+ ,edw>d ,p]cy ,rob9son's alleg$ abilities z a 8face beautifi]10 puffs f utt]ly uncritical or discr$it$ s\rces & a te/imonial to ! value ( a prepo/]\s 8fat cure0 fake4 ,) ! be/ bra9s ( ! _w at "w on ! problem ( canc]1 x is reasonable to assume t any man :o has f\nd out ev5 a little m ?an has previ\sly be5 discov]$ or is able to accompli% ev5 a little bett] results ?an ! av]age 9 ! treatm5t ( ?is dread$ disease1 w\ld be well kn[n to sci5tific m$ic9e4 99 99 99 99 99 ,aft] ?is article 0 9 type physicians began s5d+ 9 ,no4 #c 7,april1 #aiba7 ( ,!rapeutic ,leaves4 ,?is is /ill ano!r repr9t ( ,nos4 #a & #b1 ) m9or *anges4 ,9 ! fir/ two1 ,tek>k9 is describ$ z 8a solution ( potassium nitrate ( special /r5g?20 9 ,no4 #c x becomes 8a special solution conta9+ potassium nitrate40 ,9 ,nos4 #a & #b1 ,rob9son describ$ an alleg$ case ( 8,canc] ( ! ,rectum ,treat$ ) ,tek>k940 ,9 ,no4 #c ?is becomes 8,m$ic9al ,treatm5t ,cures ,canc] ( ! ,rectum40 ,9 ,no4 #c ! names ( ! editors1 assi/ant editor & g5]al manag] are elim9at$4 ,illu/ration ,! inside back cov] ( ,no4 #c conta9s an adv]tisem5t ( ,tek>k91 9 :i* physicians are w>n$ t 8,canc] ( ! ,lung ,may ,pres5t ,diagno/ic ,signs ( ,tub]culosis40 ,x conta9s ! fur!r />tl+ in=mation t ! p>ticul> micro-organism responsible = pulmon>y tub]culosis is ! ,klebs-,loeffl] bacillus6 ,?us3 8,! ,klebs-,loeffl] bacillus may f9d a suitable habitat 9 a malignant area ( lung tissue & ?rive !re94 ,! pres5ce ( ! bacillus does n necess>ily exclude ! pres5ce ( canc]4 ,a *ronic c\gh ) blood-/reak$ sputum may be ! result ( tub]culosis & canc]40--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,may #bh1 #aiba47 ,,tyree',s ,,antiseptic ,,p[d] ,,aga9 ,! 8,e?ical & ,comm]cial ,requirem5ts0 ( ! ,drug ,bus9ess 8,i am fond ( ! retail drug bus9ess & foll[ x e day ( my life4 ,i "k & obs]ve to ! fulle/ ext5t its e?ical & comm]cial requirem5ts40 ,?is f a circul> lett] rec5tly receiv$ by physicians1 & sign$ ,j4 ,s4 ,tyree1 :o asks t he be =giv5 = writ+ y p]sonally1 b !re are sev]al reasons :y he ?9ks ! circum/ances w>rant x4 ,all ( :i* is prelim9>y to call+ att5tion to an enclosure1 :i* accompanies ! circul> lett]1 & is describ$ z a 8%ort memor&um0 submitt$ = 8y\r consid]ation40 ,! 8memor&um0 is a f\r-page leaflet ( :i* ?ree pages are devot$ to 8,tyree's ,antiseptic ,p[d]40 ,"o ( ^! ?ree pages is a reproduction ( a lett] on ! /ation]y ( ! ,surgeon ,g5]al's ,(fice ( ! ,w> ,dep>tm5t1 & sign$ 8,w4 ,m4 ,gray1 ,m4,d41 ,microscopi/1 ,army ,m$ical ,museum2 ,pa?ologi/ to ,provid5ce ,hospital40 ,! lett] describes a s]ies ( 8bact]iological & comp>ative te/s0 made by ,dr4 ,gray ) ,tyree's ,antiseptic ,p[d]4 ,! entire second page ( ! circul> is giv5 ov] to ! results ( ^! bact]iologic te/s :i* comp>e v>i\s /r5g?s ( ,tyree's ,antiseptic ,p[d] ) 8m]curic bi*lorid10 ph5ol & =maldehyde4 ,! physicians :o receiv$ ?is adv]tis+ mat]ial 9 ,april1 #aiai1 might easily ov]look ! fact t ,dr4 ,gray has be5 dead sev]al ye>s1 t ! lett] :i* is reproduc$ is dat$ ,jan4 #c1 #ahij1 & t ! bact]iologic te/s 7 made 9 #ahhi--?irty ye>s ago6 ,! ,c\ncil on ,ph>macy & ,*emi/ry 9 #aijfbeh publi%$ ! results ( an analysis ( ,tyree's ,antiseptic ,p[d] :i* %[$ t al?\gh ! /uff 0 adv]tis$ z a mixture ( borax & alum1 x 0 9 fact ess5tially a mixture ( z9c sulphate & boric acid4 ,! publication ( ! ,c\ncil's report 9 #aijf1 %[+ ! falsity ( ! =mula1 br\ght out ! admission t ! composition _h rec5tly be5 *ang$4 ,c]ta9 x is1 h[ev]1 t = at lea/ a decade pa/1 ! ,tyree product has be5 a z9c sulphate-boric acid prep>ation4 ,yet1 accord+ to ! manufactur]'s own /atem5t1 ,tyree's ,antiseptic ,p[d] 9 #ahhi1 :5 ,dr4 ,gray made 8 bact]iologic te/s1 0 an entirely diff]5t sub/ance f ! pres5t mixture4 #beh ,at ?is "t ,tyree's ,antiseptic ,p[d] 0 an 8e?ical propriet>y0--heav5 save ! m>k6--& adv]tis$ only to physicians4 ,lat]1 z ,! ,j\rnal has %[n1 x ent]$ ! 8pat5t m$ic9e0 field z 8ideal = d\*e0 & ! 8be/ prev5tative kn[n40 ,! articles on ?is no/rum are repr9t$ 9 ! n9? edition ( 8,! ,propag&a = ,re=m40 ,"h !n we h a manufactur] publi%+ 9 #aiai1 9 behalf ( a c]ta9 product1 te/s t 7 made 9 #ahhi ) a product ( diff]5t composition1 al?\gh ( ! same "n6 ,is ?is obs]v+ 8to ! fulle/ ext5t0 ! 8e?ical & comm]cial requirem5ts0 ( ! 8retail drug bus9ess08 ,!re is no sci5tific excuse = su* a mixture z ,tyree's ,antiseptic ,p[d]4 ,if1 h[ev]1 physicians feel t !y mu/ use an irrational conglom]ation su* z ?is1 :y n prescribe ,pulvis ,antisepticus1 ,n4 ,f48 ,l ! ,tyree product1 ?is1 too1 is ess5tially a mixture ( z9c sulphate & boric acid1 ) m9ute am\nts ( ph5ol1 eucalyptol1 m5?ol & ?ymol1 to say no?+ ( a da% ( salicylic acid4 ,?is (ficial article has at lea/ ! virtue ( con/ancy ( /r5g?1 composition & purity assur$ "u ! f$]al ,food & ,drugs ,act4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,may #ag1 #aiai47 ,,:eel]',s ,,tissue ,,phosphates 8,! ,commission] ( ,heal? directs me to call to y\r att5tion ! enclos$ adv]tisem5t issu$ by ,t4 ,b4 ,:eel]1 ,m4,d41 ,company1 ,montreal1 ,canada1 9 :i* ! "n ( ! ,association's ,j\rnal is be+ us$40 ,accompany+ ?is brief note to ,! ,j\rnal f ! secret>y ( ,dr4 ,hav5 ,em]son1 ,commission] ( ! ,dep>tm5t ( ,heal? ( ! ,city ( ,new ,york1 0 a f\r page leaflet devot$ to ! exploitation ( 8,:eel]'s ,tissue ,phosphates40 ,! tr5d ( ! circul> is to lead ! av]age read] to inf] t ,! ,j\rnal ( ! ,am]ican ,m$ical ,association has endors$ ,:eel]'s ,tissue ,phosphates4 ,= example1 9 describ+ ! prep>ation "o reads3 8,x embodies 444 ! be/ rec5t sci5tific op9ion conc]n+ ! treatm5t ( ! disease 7tub]culosis7 z /at$ 444 by ! (ficial ,j\rnal ,a4 ,m4 ,a40 ,else:]e 9 ! circul> ,! ,j\rnal's criticisms ( ! hypophosphites & ! glyc]ophosphates 7propriet>y prep>ations :i* are competitors ( ! ,:eel] product7 are quot$ & twi/$ into a tribute to ! +r$i5ts ( ,:eel]'s ,tissue ,phosphates4 ,g>bl+ quotations1 di/ort+ /atem5ts1 sep>at+ phrases f _! contexts & omitt+ qualify+ clauses1 all = ! purpose ( mak+ out a case = "s propriet>y rem$y is a trick z old z quack]y itself4 ,t x %\ld be us$ 9 adv]tis+ ,:eel]'s ,tissue ,phosphates is entirely fitt+4 ,obvi\sly1 ! ,t4 ,b4 ,:eel]1 ,m4,d41 ,company e/eems ! op9ion ( ,! ,j\rnal on ph>macologic matt]s4 ,?is be+ ! case1 x %\ld1 9 ! int]e/ ( tru? & sci5tific accuracy1 publi% 9 its adv]tis+ circul>s j :at ,! ,j\rnal has said ab\t ,:eel]'s ,tissue ,phosphates4 ,x c\ld n d ?is bett] ?an by quot+ f a rec5t editorial note :i* comm5t$ on a report ( ! ,*emical ,laboratory on ?is prep>ation4 ,"h is "p ( ! ,! ,j\rnal's comm5t3 8#8,:eel]'s ,tissue ,phosphates' is an unsci5tific %otgun mixture ^: mo/ active & p[]ful drug is ! alcohol x conta9s4 ,t x 0 n ye>s ago relegat$ to ! realms ( obsolete & disc>d$ prep>ations is a comm5t>y alike on ! lack ( sci5tific discrim9ation & on ! p[] ( adv]tis+40 ,"h we h 8,:eel]'s ,tissue ,phosphates0 /ripp$ ( ! v]bal cam\flage ) :i* its exploit]s h inve/$ x4--7,editorial f ,! ,j\rnal ,a4 ,m4 ,a41 ,sept4 #bb1 #aiag47 ,,brief] ,,p>agraphs ,alcre/a ,lotion ,to ! ,editor3--,:at is ! composition ( ,alcre/a ,lotion8 ,l4 ,t4 ,a4 ,hott51 ,m4,d41 ,p>is1 ,idaho4 ,accord+ to a circul> 9 our files1 8,alcre/a ,d5tal ,lotion-,libby0 conta9s 8,emet91 ! active amebicidal pr9ciple ( ,ipecac1 toge!r ) ,b5zoic ,acid1 ,?ymol1 ,eucalyptol & ,aromatics40 ,! !ory t emet9 is an active amebicide aga9/ pyorrhea alveol>is has be5 explod$4 ,9 ?is connection1 x is int]e/+ to note t ! firm does n li/ ! product 9 ! late/ catalogue 9 our files4--7,qu]y f ,! ,j\rnal ,a4 ,m4 ,a41 ,oct4 #bi1 #aiba47 ,calcid9 ,tablets 7,abbott7 ,to ! ,editor3--,:at is ! composition ( calcid9 tablets 7,abbott7 & :at is _! value8 ,j4 ,s4 ,,answ]4--,calcid9 is claim$ to be a mixture ( iod91 lime & />*4 ,9 contact ) wat]1 ! iod9 & lime react to =m calcium iodid & calcium iodate4 ,by ! acid ( ! ga/ric juice1 ! calcium iodid & calcium iodate are decompos$ ) lib]ation ( free iod94 ,! adm9i/ration ( calcid9 tablets am\nts to giv+ free 7elem5t>y7 iod94 ,9 ! pa/1 ! adv]tis+ = calcid9 has conta9$ ! unw>rant$ claim m or less directly t x 0 ! mo/ effective & only non9juri\s prep>ation ( iod9 = int]nal use1 & t x possesses all ( ! valuable prop]ties ( ! iod9 ) all ( ! objectionable effects left out4 ,s f> z we "k1 ! effects produc$ by ! adm9i/ration ( free iod9 d n diff] f ^? produc$ by ! adm9i/ration ( iodids &1 !re=e1 calcid9 has no advantage ov] ! iodids1 su* z sodium iodid4--7,qu]y 9 ,! ,j\rnal ,a4 ,m4 ,a41 ,sept4 #be1 #aibj47 ,di-,crotal9 ,treatm5t ( ,epilepsy ,to ! ,editor3--,d y h any lit]ature or in=mation relative to ! ,di-,crotal9 treatm5t = epilepsy8 ,i w be v grateful if y c furni% in=mation z to me?od ( prep>ation1 rationale ( ! treatm5t1 etc4 ,r4 ,c4 ,deck]1 ,capta91 ,m4 ,r4 ,c41 ,u4 ,s4 ,soldi]s' ,home1 ,wa%+ton1 ,d4 ,c4 ,,answ]4--,di-,crotal9 is a rattlesnake v5om prep>ation sold by ! ,swan-,my]s ,company ( ,indianapolis z a 8,treatm5t = ,epilepsy1 ,*orea1 ,bron*ial ,a/hma1 ,*ronic or ,h]$it>y ,n]v\s ,heada*e1 ,n]v\s ,pro/ration ,incid5t to ,*ange ( ,life1 ,hy/]ia-,mania1 ,insomnia1 ,neura/h5ia1 etc40 ,dr4 ,?omas ,j4 ,mays ( ,philadelphia advocat$ ! use ( rattlesnake v5om = tub]culosis4 ,lat] 8 =m] assi/ant1 ,dr4 ,r4 ,h4 ,spangl]1 us$ ! same mat]ial 9 ! treatm5t ( epilepsy4 ,t any measure ( success suffici5t to ju/ify ! adoption ( ! rattlesnake v5om or crotal9 treatm5t = epilepsy has result$ is n to be conclud$ f ! available reports4 ,/ill less evid5ce is !re = ! use ( rattlesnake v5om 9 ! li/ ( conditions = :i* ! ,swan-,my]s ,company has recomm5d$ its prep>ation4 ,!re are a numb] ( good reasons :y a cauti\s physician w %un ! adm9i/ration ( ?is treatm5t & advise aga9/ x4 ,j4 ,f4 ,&]son1 work+ 9 ! hygi5ic laboratory ( ! ,unit$ ,/ates ,public ,heal? ,s]vice1 report$ a dea? f ! crotal9 treatm5t 9 consequ5ce ( infection1 & reports t ! m>ket supply ( crotal9 solution & crotal9 tablets is highly contam9at$4 ,he also f\nd bo? crotal9 & crotal9 solution to v>y 9 activity4 ,! use ( rattlesnake v5om 0 discuss$ 9 ,! ,j\rnal1 ,m>* #ae1 #aiac1 p4 #hej4--7,qu]y 9 ,! ,j\rnal ,a4 ,m4 ,a41 ,aug4 #ag1 #aiah47 ,e/iv9 ,to ! ,editor3--,:at is 8,e/ev910 or some?+ l t8 ,x is said to be good 9 hay-fev]4 ,con/ant ,read]4 ,,answ]4--,! product call$ 8,e/iv90 is sold by ,s*ieffel9 & ,company1 ,new ,york4 ,a reque/ = a /atem5t ( ! composition ( ?is prep>ation s5t to ,s*ieffel9 & ,company by ! ,c\ncil on ,ph>macy & ,*emi/ry br\ght ! indef9ite &1 !re=e1 mean+less /atem5t t 8#8,e/iv9' is an extract ( ,rosa ,gallica conta9+ no alcoholic or =eign +r$i5ts40--7,qu]y f ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #ab1 #aiba47 ,iron ,ars5ite ,to ! ,editor3--,c y in=m me h[ iron ars5ite c be prep>$ = subcutane\s injection8 ,a comm]cial firm furni%es physicians ) ampules ( ars5ite ( iron4 ,is ?is really ars5ite ( iron8 ,s4 ,h4 ,kempn]1 ,m4,d41 ,new ,york4 ,,answ]4--,f]ric ars5ite 7iron ars5ite7 is 9 itself relatively insoluble 9 wat]1 b may be treat$ ) ammonium citrate1 ! result+ product ?us be+ soluble2 ! latt] sub/ance 0 at "o "t describ$ 9 ,new & ,non(ficial ,rem$ies z 8,f]ric ,ars5ite1 ,soluble0 & is sometimes sold z a solution 9 ampule =m4 ,9 #aiab1 ! ,c\ncil on ,ph>macy & ,*emi/ry delet$ 8,f]ric ,ars5ite1 ,soluble0 f ,new & ,non(ficial ,rem$ies because 8"o _c1 9 adm9i/]+ ,f]ric ,ars5ite1 ,soluble1 give a useful dose ( iron )\t giv+ too mu* ars5ic2 &1 vice v]sa1 "o _c give a safe dose ( ars5ic )\t giv+ too little iron40 ,! ,c\ncil1 !re=e1 held ! prep>ation to be irrational & unsci5tific4--7,qu]y 9 ,! ,j\rnal ,a4 ,m4 ,a41 ,feb4 #ai1 #aiba47 ,k-,y ,lubricat+ ,jelly ,to ! ,editor3--#a4 ,:at is ! composition ( 8,k-,y ,lubricat+ ,jelly08 #b4 ,c y furni% a =mula = a simple nongreasy lubricat+ jelly8 ,s4 ,t4 ,,answ]4--#a4 ,! composition ( 8,k-,y ,lubricat+ ,jelly0 has n be5 divulg$4 ,exam9ation ( ! adv]tis+ matt] reveals only mean+less /atem5ts1 su* z3 8,?is is a judici\s comb9ation ( vegetable products 444 ,comb9$ 9 well balanc$ proportions ) non-irritat+ antiseptics 44410 8,x incorporates a suffici5t quantity ( mild antiseptics 7( ! ,?ymol class7 4440 & 8444 conta9s ,,no =maldehyde40 #b4 ,probably a simple tragacan? jelly1 :i* c be made *eaply1 w produce ! same effects z ^? ( ! propriet>y prep>ation4 ,! foll[+ =mula 0 publi%$ by ,mr4 ,j4 ,k4 ,?um1 apo!c>y at ! ,g]man ,hospital1 ,philadelphia 7,druggi/s ,circul>1 ,septemb]1 #aiae1 p4 #ehf73 ,,lubricat+ ,,jelly ,tragacan?1 :ole #c gm4 ,glyc]9 #be c4c4 ,ph5ol #a4e gm4 ,di/ill$ wat]1 a suffici5t quantity to make #cjj c4c4 ,! tragacan? is brok5 9 small pieces1 & put into a wide-m\!d bottle2 ! o!r +r$i5ts are add$ & ! bottle frequ5tly %ak54 ,9 reg>d to ?is =mula1 ,mr4 ,?um writes3 ,x has be5 us$ 9 our gynecologic dep>tm5t = ye>s4444 ,= ! la/ six ye>s we h be5 disp5s+ x 9 collapsible tubes ?r\gh\t ! hospital = g5]al "w4--7,correspond5ce 9 ,! ,j\rnal ,a4 ,m4 ,a41 ,may #ab1 #aiag47 8,nikalg90 ,to ! ,editor3--,colli]'s has a special article ?is week on 8,nikalg940 ,h y any in=mation on ?is subject8 ,x s\nds l no/rum /uff4 ,p4 ,r4 ,m9ahan1 ,m4,d41 ,fond du ,lac1 ,wis4 ,,answ]4--8,nikalg90 is said to be ! 8inv5tion0 ( ,gordon ,edw>ds1 an eng9e]4 ,l>ge claims = its ane/hetic & antiseptic virtues h be5 made4 ,:ile no v def9ite in=mation seems to be =?com+ reg>d+ ! prep>ation1 x has be5 said to be 8compos$ ( qu991 hydro*loric acid & urea40 ,?is w\ld indicate t 8,nikalg90 may be no?+ m wond]ful ?an ! well kn[n local ane/hetic1 qu99 & urea hydro*lorid1 ! ,qu99ae et ,ureae ,hydro*loridum ( ! ,u4 ,s4 ,ph>macopeia1 or a modification ( x4--7,qu]y 9 ,! ,j\rnal ,a4 ,m4 ,a41 ,sept4 #bb1 #aiag47 ,p]tuss9 & ,syrup ( ,?yme ,to ! ,editor3--,a %ort "t ago ,i receiv$ a sample ( 8,p]tuss90 & us$ "s 9 an ob/9ate case ( bron*itis ) excell5t results4 ,i h s9ce receiv$ a catalog f a ph>maceutical firm1 :i* adv]tises syrup ( ?yme4 ,i h se>*$ = a =mula to make my own syrup ( ?yme1 b h n be5 able to f9d "o4 ,w y publi% "o8 ,e4 ,f4 ,b5n]1 ,m4,d41 ,sal=dville1 ,pa4 ,,answ]4--,! subjo9$ =mula yields a product v simil> to 8,p]tuss90 9 ta/e1 flavor1 composition1 & probably 9 activity z well3 ,fluidextract ( ?yme #ae c4c4 ,glyc]9 #ae c4c4 ,syrup to make #ajj c4c4 ,! orig9al ,g]man prep>ation conta9$ #a4e gm4 ( sodium bromid 9 ea* hundr$ cubic c5timet]s1 & ?is might be add$ to ! =ego+ =mula ) advantage1 s f> z action is conc]n$4 ,h[ev]1 a sample ( 8,p]tuss90 pur*as$ 9 ! op5 m>ket 9 ! ,unit$ ,/ates fail$ to respond to te/s = bromids4 ,z fluidextract ( ?yme is n (ficial1 ?is =mula is pres5t$ z furni%+ an acceptable prep>ation3 ,?yme1 9 ,no4 #fj p[d] #ajj gm4 ,moi/5 ) a mixture (3 ,wat] #be c4c4 ,alcohol #ae c4c4 ,glyc]9 #aj c4c4 ,aft] /&+ five h\rs1 pack 9 a p]colator4 ,exhau/ ) a m5/ruum ( alcohol1 #a volume1 & wat]1 #c volumes4 ,res]ve ! fir/ #he c4c4 ( p]colate4 ,conc5trate ! weak p]colate to a s(t extract & dissolve 9 ! res]v$ portion4 ,make up to #ajj c4c4 by addition ( a mixture ( alcohol1 #a volume1 & wat]1 #c volumes4 ,o!r aromatic expectorants1 su* z t]eb5e1 t]p9 hydrate or creosote1 might be expect$ to h simil> b great] effect 9 *ronic bron*itis4 7,qu]y 9 ,! ,j\rnal1 ,a4 ,m4 ,a41 ,m>* #bg1 #aibj47 ,qu99 & ,urea ,hydro*lorid ,to ! ,editor3--,c\ld y tell me :y qu99 & urea hydro*lorid has n become m popul> = local ane/hesia8 ,is x less efficaci\s or m toxic ?an o!r prep>ations8 ,if x is useful1 c y "n "s tru/wor?y firm or br&8 ,please omit my "n 9 answ]+4 ,l4 ,f4 ,c41 ,m4,d41 ,mexico4 ,,answ]4--,qu99 & urea hydro*lorid 8has ! actions ( qu994 ,:5 inject$ hypod]mically x ex]ts an ane/hetic action mu* m prolong$ ?an t ( coca90 7,useful ,drugs1 ,ed4 #d1 #aibj1 p4 #abg74 ,x has be5 po9t$ out editorially 9 ,! ,j\rnal 7,feb4 #ad1 #aibj1 p4 #dfb7 t qu99 has be5 reg>d$ = m ?an half a c5tury by toxicologi/s z a protoplasmic poison capable ( de/roy+ v>i\s =ms ( animal & vegetable cells1 & h5ce x ne$ n be surpris+ t tissue necrosis may be produc$ by /rong solutions ( ! qu99 salts4 ,t ?is delet]i\s reaction actually does occur & has militat$ aga9/ ! g5]al use ( qu99 & urea hydro*lorid is confirm$ by ! report ( ! ,committee on ! ,advantages & ,disadvantages ( ,local ,ane/hesia 9 ,nose & ,?roat ,"w 7,! ,j\rnal1 ,july #ca1 #aibj1 p4 #cae74 ,to quote3 ,! only local ane/hetic t produces edema & sl\gh+ is qu99 & urea hydro*lorid4 ,s _m /atem5ts 7 f\nd 9 ! lit]ature t ?is ane/hetic has be5 ab&on$ 9 o!r fields ( m$ic9e because ( edema & sl\gh+1 t writ]s :o _h pres5t$ favorable reports 9 nose & ?roat op]ations 7 communicat$ ) by y\r committee4 ,"o writ] :o _h record$ #cij cases ( tonsillectomies extoll+ ?is ane/hetic1 :i* he _h us$ = f\r ye>s & is /ill s record$1 n[ /ates t he has n us$ x 9 two ye>s1 al?\gh no publication has be5 made retract+ 8 =m] endorsem5t4 ,/ill ano!r writ]1 :o /at$ t qu99-urea came ne>e/ ! ideal local ane/hetic1 n[ /ates t he has ceas$ us+ x4 ,y\r committee f9ds t z f> z nose & ?roat op]ations are conc]n$1 ?is drug has practically gone into 8innocu\s desuetude40 ,! ane/hesia produc$ by ?is drug at ! "t ( op]ation is good & ! recov]y ( ! pati5t might (t5 be enhanc$ by its use if x did n h ! s]i\s drawback4 ,! product is (ficial 9 ! ,u4 ,s4 ,ph>macopeia1 & may be obta9$ f any reputable ph>maceutical h\se4--7,qu]y 9 ,! ,j\rnal ,a4 ,m4 ,a41 ,aug4 #ba1 #aibj47 ,ricord ,pills & ,h\se ,organ ,!rapeutics ,to ! ,editor3--,my mail is frequ5tly clutt]$ ) pseudo-sci5tific data f v>i\s manufactur]s ( propriet>y rem$ies :i* conta9 z mu* real sci5tific in=mation z ! ,police ,gazette4 ,i am enclos+ a sample page ( su* a p]iodical4 ,! article has be5 s clev]ly word$ 9 ! fir/ p>agraph1 z to impress ! un?9k+ ) ! idea t sodium cacodylate is sup]ior to arsph5am91 :5 we "k 9 reality t sodium cacodylate has be5 prov$ practically wor?less 9 syphilis 7vide 8,v5>s5074 ,"o case is report$1 9 :i* tw5ty injections ( sodium cacodylate 7 adm9i/]$ intrav5\sly1 f ,octob] #bc to ,decemb] #ad4 ,on ,decemb] #ah1 a ,wass]mann te/ prov$ negative1 x _h be5 /rongly positive on ,octob] #bj1 b dur+ ! same int]val f ,octob] #bc to ,decemb] #ad1 ! pati5t _h be5 tak+ by m\? 8,ricord pills0 ea* conta9+ half a gra9 ( yell[ iodid ( m]cury2 grant$ t he _h tak5 ^! pills regul>ly1 dur+ all t "t1 x might well be t ! ,wass]mann w\ld be %>ply influ5c$ by !m4 ,aga91 a negative ,wass]mann 9 ! mid/ ( treatm5t proves little2 x might be positive aga9 9 a few days4 ,! article /imulates ! fur!r use ( a product ( kn[n wor?lessness 9 ! treatm5t ( syphilis4 ,h[ any "o c use sodium cacodylate 9 pref]5ce to arsph5am9 9 syphilis is beyond me4 ,if ,i mi/ake n1 ! ,propag&a ,dep>tm5t has n tak5 up ! matt] ( ^! v>i\s pamphlets ( ! drug companies1 su* z ! ,doctor's ,factotum1 ,!rapeutic ,notes1 etc41 laud+ to ! skies su* articles z 8,s5g10 8,cact9a ,pillets10 etc41 ad nauseam4 ,! sadde/ "p ( ! :ole ?+ is t x mu/ br+ returns f ! un?9k+1 o!rwise !y w\ld soon disappe>1 :i* w\ld be a great relief = ! scrubwom5 :o empty our wa/e baskets4 ,paul ,e4 ,be*et1 ,m4,d41 ,new ,york4 ,comm5t4--,! 8sample page0 s5t by ,dr4 ,be*et is f ! ,m>*-,april1 #aiah1 numb] ( ,p>ke1 ,davis ,company's ,!rapeutic ,notes4 ,x conta9s an 8,orig9al ,communication0 on 8,! ,treatm5t ( ,syphilis ) ,sodium ,cacodylate1 by ,adolph ,lappn]1 ,m4,d41 ,detroit1 ,mi*40 ,! 8article10 :ile nom9ally devot$ to ! praise ( sodium cacodylate1 is virtually a puff = 8,ricord ,pills40 a ,p>ke1 ,davis ,co4 product4--7,correspond5ce 9 ,! ,j\rnal ,a4 ,m4 ,a41 ,july #ac1 #aiah47 ,/annoxyl ,to ! ,editor3--,i am v anxi\s to "k :e!r t9 or /ann\s oxid 7,sn,o7 has or has _h any place among useful drugs4 ,i h se5 su* a prescription giv5 9 ! treatm5t ( muc\s colitis1 & w\ld be v glad to le>n :at its use may be4 ,c>los ,manuel ,g>cia1 ,m4,d41 ,havana1 ,cuba4 ,,answ]4--,rec5tly1 on ! assumption t t9 work]s are less tr\bl$ ) boils ?an ! av]age p]son1 two ,fr5* inve/igators propos$ ! use ( t9 comp\nds 9 ! treatm5t ( /aphylococcic infections4 ,bas$ on _! "w1 a propriet>y prep>ation--,/annoxyl--has be5 plac$ on ! m>ket :i* is claim$ to be 8compos$ ( /ann\s oxide & specially purifi$ metallic t940 ,absurd claims are made = ! product3 = in/ance1 8444 ,we h no hesitation 9 (f]+ ,,/annoxyl--9 ,tablets or ,ca*ets--z ! only true specific = diseases ( ,/aphylococcus orig940 ,! available evid5ce is unconv9c+ & 9 no way w>rants su* exagg]at$ /atem5ts4--7,qu]y 9 ,! ,j\rnal ,a4 ,m4 ,a41 ,m>* #f1 #aibj47 ,to ! ,editor3--,i 0 mu* int]e/$ 9 y\r answ] to a qu]y ab\t ,/annoxyl 7,! ,j\rnal1 ,m>* #f1 p4 #fbi74 ,i submit ! foll[+ exp]i5ce z a confirmatory note3 ,:ile s]v+ ) ! ,royal ,army ,m$ical ,corps 9 ,egypt1 ,i = "s "t _h *>ge ( ! m$ical division ( a hospital 9 :i* mo/ ( ! sk9 diseases occurr+ among soldi]s 9 ! di/rict 7 treat$4 ,! mo/ common conditions 7 boils & septic sores1 *iefly due to /aphylococcal infection1 ?\gh sev]al ( ! latt] cases 7 diph!ritic4 ,! treatm5t adopt$ 0 t 9 ord9>y use1 namely1 incision & evacuation ( pus1 application ( antiseptic dress+s1 & 9 mo/ cases employm5t ( ! specific vacc9e4 ,x 0 possible to judge ( ! efficacy ( any v>iations ( treatm5t1 z !re 7 always pl5ty ( cases und]go+ ! usual treatm5t ) :i* ! results c\ld be controll$4 ,an available supply ( ,/annoxyl1 a propriet>y rem$y consi/+ ( a mixture ( metallic t9 & t9 oxid1 enabl$ me to give x a fair trial 9 full doses 9 eight cases ( boils ( av]age sev]ity1 9 :i* culture reveal$ ! infect+ organism to be ,/aphylococcus aureus4 ,! boils 7 treat$ locally z usual1 b no vacc9e 0 giv54 ,no improvem5t c\ld be demon/rat$ 9 ^! cases t c\ld n be %[n 9 o!r cases simil>ly treat$ ) ! omission ( ,/annoxyl2 9 fact1 ?ree ( ! treat$ cases 7 mu* long] 9 cle>+ up ?an ! untreat$ controls4 ,eight cases d n con/itute a v l>ge s]ies f :i* to draw conclusions2 b if ! prep>ation 7 z good z ! descriptive lit]ature w\ld lead "o to believe1 "o %\ld h expect$ an evid5t result 9 at lea/ "o ( ^! cases4 ,x has be5 /at$ t ,/annoxyl does n inhibit ! gr[? ( /aphylococci1 b only r5d]s ! gr[? less virul5t4 ,x is kn[n t a c]ta9 am\nt ( t9 may be absorb$ f ! inte/9e1 & ,salant1 ,rieg] & ,treuh>dt h %[n t 9 c]ta9 cases t9 may be reta9$ = "s "t 9 ! sk92 b x is que/ionable :e!r1 :5 prep>ations ( t9 are giv5 by m\?1 any rea*es ! /aphylococci 9 ! boils1 or at any rate en\gh mat]ially to influ5ce _! gr[? or virul5ce4 ,9 ! cases treat$ by me1 ! results did n at all sugge/ t ,/annoxyl 0 a 8specific = diseases ( /aphylococcal orig940 ,j4 ,w4 ,c4 ,gunn1 ,m4,a41 ,m4,b41 ,*4,b41 ,cape ,t[n4 ,pr(essor ( ,ph>macology1 ,univ]sity ( ,cape ,t[n4 --7,correspond5ce 9 ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #bj1 #aibj47 ,syphilodol ,to ! ,c\ncil on ,ph>macy & ,*emi/ry3--,if y h n already done s1 w y k9dly exam9e & report on 8,syphilodol0 adv]tis$ 9 ! enclos$ pamphlet8 ,b4 ,c4 ,p$]s51 ,m4,d41 ,new ,york4 ,to ! ,editor3--,h y any in=mation conc]n+ ! enclos$ half page adv]tisem5t ( ,syphilodol f ! ,urologic & ,cutane\s ,review8 ,edw>d ,s4 ,newell1 ,m4,d41 ,pelham1 ,n4 ,y4 ,to ! ,editor3--,i am enclos+ an adv]tisem5t = a sub/ance call$ 8,syphilodol0 manufactur$ 9 ,new ,york4 ,am n famili> ) ?is article nor h ,i se5 x adv]tis$ 9 ! high] class j\rnals4 ,c y tell me :e!r ,! ,j\rnal's dep>tm5t ( ,new & ,non(ficial ,rem$ies has pass$ on ?is article or :e!r y h any data conc]n+ x8 ,x looks a trifle fi%y to me4 ,l\is ,l]oy1 ,m4,d41 ,memphis1 ,t5n4 ,to ! ,editor3--,i am s5d+ ! enclos$ correspond5ce ,syphilodol lett]s to y z x looks z if x might h "s int]e/+ features f ! po9t ( view ( y\r no/rum dep>tm5t4 ,isadore ,dy]1 ,new ,orleans1 ,la4 ,,answ]4--,^! are b "s ( ! inquiries t h be5 receiv$ on ?is subject & x is enc\rag+ to note ! sci5tifically critical attitude ( physicians t[>d new !rapeutic ag5ts4 ,accord+ to ! ,fr5* ,m$ic9al ,company1 ,inc41 :i* m>kets ?is product1 8,syphilodol is a syn!tic *emical product ( silv]1 ars5ic & antimony44440 ,n[h]e 9 ! adv]tis+ matt] is !re any m def9ite /atem5t z to ! composition ( ?is new 8syn!tic0 ?an t j quot$4 ,! product is n[ "u exam9ation 9 ! ,association's laboratory & :5 ?is is complet$ a m detail$ report w d\btless be =?com+4 ,at pres5t ! "w has progress$ suffici5tly to %[ t ,syphilodol tablets conta9 consid]able quantities ( m]cury6 ,al?\gh ! adv]tis+ leaflets claim t ! prep>ation is 8! =mula ( ! late ,dr4 ,alfr$ ,f\rni] ( ,p>is0 & _h be5 exhau/ively te/$ by ,met*nik(f1 :o is alleg$ to h f\nd x sup]ior to salv>san & neosalv>san1 yet1 /range to say1 a c>eful se>* ( ,fr5* m$ical j\rnals fails to %[ any reports on ,syphilodol4 ,v]b4 sap4--7,qu]y 9 ,! ,j\rnal ,a4 ,m4 ,a41 ,feb4 #bc1 #aiah47 ,?ialion ,to ! ,editor3--,k9dly in=m me reg>d+ ?ialion1 manufactur$ by ! ,vass ,*emical ,company1 ,danbury1 ,conn4 ,please omit my "n & address 9 answ]+ 9 ,! ,j\rnal4 ,h4 ,c4 ,w4 ,,answ]4--,?ialion is an heirloom ( ! days :5 li?ium salts 7 support$ to be nature's antidote = all k9ds ( ailm5ts1 suppos$ly due to excess ( uric acid4 ,x 0 adv]tis$ z a uric acid elim9ant & !re=e good = all k9ds ( diseases4 ,! ,c\ncil on ,ph>macy & ,*emi/ry publi%$ a report on ?ialion 9 ,! ,j\rnal1 ,nov4 #c1 #aijf4 ,at t "t ?ialion 0 adv]tis$ by ! ,vass ,*emical ,company z a 8laxative salt ( li?ia0 ) ! *emical =mula 8#c,li,o4,na,o4,,s4#g;,,ho10 & an elaborate /ructural =mula 0 also furni%$4 ,! ,c\ncil report$ t ! product 0 n a def9ite *emical comp\nd1 b a mixture consi/+ *iefly ( sodium sulphate1 sodium citrate & small am\nts ( li?ia4 ,9 rec5t adv]tisem5ts1 ?ialion is ref]r$ to z 8,a ,non-,eff]vesc+ ,li?iat$ ,laxative ,salt10 8a non-hygroscopic1 non-deliquesc5t1 granul> salt ( li?ia10 etc41 b ! *emical =mula does n appe>1 nor is any def9ite /atem5t ( composition furni%$4 ,accord+ to ?is adv]tisem5t1 ! 8indications0 = ?ialion are3 8g\t1 rheumatism1 uric acid dia!sis1 con/ipation1 acute & *ronic1 sluggi% liv]1 ,bright's disease1 album9uria ( pregnancy1 a/hma1 incont95ce ( ur9e1 gravel1 cy/itis1 *ronic lead poison+1 heada*e1 neuralgia1 neura/h5ia & lumbago1 ,hay fev]1 etc40--7,qu]y 9 ,! ,j\rnal ,a4 ,m4 ,a41 ,dec4 #f1 #aiai47 ,v5>s5 ,to ! ,editor3--,! foll[+ is a copy ( a lett] s5t to ! ,intrav5\s ,products ,company1 :i* ne$s no explanation3 ,june #h1 #aiag4 ,! ,intrav5\s ,products ,co41 ,d5v]1 ,colo4 ,g5tlem53--,9 reply to y\r circul> lett] "u date ( ,june #c1 may ,i say t aft] us+ a great quantity ( ,v5>s5 bo? 9 cl9ical & private cases1 ,i c see no m effect ^u ^! cases ?an if s mu* wat] _h be5 adm9i/]$4 ,?is is also ! report ( ,don ,r4 ,black1 pa?ologi/ = ,bell ,memorial ,hospital1 ,univ]sity ( ,kansas4 ,9 our exp]im5ts all bloods 7 te/$ be=e & aft] ea* adm9i/ration ( ?is product4 ,william ,a4 ,wilson1 ,m4,d41 ,kansas ,city1 ,mo4 7,correspond5ce 9 ,! ,j\rnal ,a4 ,m4 ,a41 ,july #g1 #aiag47 ,,"p ,,iv ,,contributions ,,f ,,! ,,j\rnal3 ,,miscellany ,,alb]t ,,abrams1 ,a4,m41 ,m4,d41 ,,ll4,d41 ,f4,r4,m4,s4 8,spondylo!rapy10 8,electronic ,reactions10 ! 8,oscillocla/10 ! 8,electrobioscope10 ,etc4 ,= "s "t ,! ,j\rnal has receiv$ inquiries ( :i* ! foll[+ rec5t examples are typical4 ,?is f an ,ohio physician3 8,please give me "s in=mation conc]n+ ,dr4 ,abrams & 8 diagno/ic & !rapeutic devices kn[n z reflexaphore & oscillocla/4 ,if ?is is publi%$ please )hold my "n40 ,a physician 9 ,massa*usetts writes3 8,c y give me any in=mation conc]n+ ,dr4 787 ,san ,francisco1 ,cali=nia1 :o reports himself able to diagnose syphilis f a drop ( blood s5t him on a blott+ pap]8 ,he has caus$ a pati5t ( m9e a great deal ( ne$less worry40 ,& f ,rhode ,isl& a physician faceti\sly inquires3 8,i am int]e/$ to "k ( ! #8,reactions ( ,abrams4' ,h y any in=mation t y c give me 9 reg>d to ?is matt]8 ,!y app>5tly d wond]ful ?+s 9 ! ,we/40 ,:ile a ,new ,york physician ackn[l$ges 8 failure to keep up ) ! times ?us3 8,to-day ,i _h occasion to see a pati5t :o m5tion$ hav+ an ,abrams te/ = gonorrheal infection ( ! pro/ate4 ,he also /at$ he wi%$ to h ,abrams' treatm5t = ! same condition4 ,c\ld y enlight5 me z to :at ^! are8 ,i ?\ght ,i _h kept myself up to date z to all new te/s & treatm5ts 9 my l9e2 b evid5tly ,i h be5 del9qu5t40 ,accord+ to our records1 ,alb]t ,abrams1 ,a4,m41 ,m4,d41 ,,ll4,d41 ,f4,r4,m4,s41 0 born 9 ,san ,francisco 9 #ahfd4 ,he 0 graduat$ 9 m$ic9e by ! ,univ]sity ( ,heidelb]g1 ,g]many1 9 #ahhb4 ,dr4 ,abrams is a memb] ( 8 local m$ical society & ?r\gh t holds fell[%ip 9 ! ,am]ican ,m$ical ,association4 ,dr4 ,abrams has writt5 volum9\sly4 ,9 #aiaj1 8 book on 8,spondylo!rapy0 78,physio-,!rapy ( ! ,sp9e07 0 review$ 9 ,! ,j\rnal4 8,spondylo!rapy0 is a neologic creation ( ,dr4 ,abrams4 ,accord+ to its disciples1 x conc]ns itself 8only ) ! excitation ( ! functional c5t]s ( ! sp9al cord0 & has be5 call$ 8! sci5ce ( evok+ ! reflexes ( ! body bo? to diagnose & to cure disease40 ,9 br++ its review ( ,abrams' book on 8,spondylo!rapy0 to a close1 ,! ,j\rnal said3 8444 "o wond]s :e!r ?is is an attempt to expla9 o/eopa?y & *iropractic to ! und]/&+ ( ! regul> practition]1 or to exploit ! v +5i\s p]cussion devices ( ! au?or1 or :e!r x is really true t m$ical m5 really "k practically no?+ ab\t ! cure ( disease ?r\gh treatm5t ( ! sp9e4 ,let u hope t x is ! latt] & t a c>eful /udy ( ?is unique volume may op5 new av5ues ( !rapy h]et(ore undream$ (40 ,:ile ! review 0 obvi\sly critical1 yet 9 adv]tis+ ! book1 ! publi%] pick$ out "p ( ! clos+ s5t5ce1 omitt$ ! context1 & quot$ ,! ,j\rnal z hav+ said3 8,let u hope t a c>eful /udy ( ?is unique volume may op5 new av5ues ( !rapy h]et(ore undream$ (40 ,:5 ?is matt] 0 br\ght to ! att5tion ( ,dr4 ,abrams1 he repli$1 8,i fail to see any real diff]5ce 9 ! two quotations0 & 8only "o 444 ) an a/igmatic m5tality0 c\ld 8see any incongruity betwe5 ! context & ! conclud+ s5t5ce40 ,yet1 9 ?is same lett] :i* attempt$ to ju/ify ! g>bl+ ( a quotation s z to make a critical review appe> a laudatory "o1 ,dr4 ,abrams decl>$ t ! review 9 "q 0 8conceiv$ & execut$ 9 a malici\s _s40 ,betwe5 #aiab & #aiad ,dr4 ,abrams gave 8cl9ical c\rses0 on 8,spondylo!rapy0 9 v>i\s p>ts ( ! c\ntry--price #ej4 ,^! 8c\rses0 7 widely adv]tis$ by an ,ohio conc]n t seems to make a specialty n only ( h&l+ ! adv]tis+ campaigns ( ^? memb]s ( ! m$ical pr(ession :o h unusual or biz>re me?ods to exploit1 b also ( act+ z an ag5t = ! sale ( su* devices & publications z may be necess>y to ! prop] practice ( ! p>ticul> br& ( !rapy t is be+ exploit$4 ,at ! "t ?is conc]n 0 featur+ ,abrams' c\rse x call$ att5tion to ! alleg$ fact t 8no class 7 sic6 s busy z ^? employ+ me*anical treatm5t su* z ,o/eopa?y1 ,*iropractic1 ,me*ano!rapy1 etc40 ,says ,dr4 ,abrams3 8,despite ! fury ( tongue or ! trucul5ce ( ! p51 ! o/eopa? & *iropractor are inspir+ ! confid5ce ( ! community ) _! sy/ems4 ,"r or wrong 9 _! !ory1 !y are1 9 vulg> p>lance1 #8deliv]+ ! goods4' ,spondylo!rapy 0 a product ( necessity--! translation ( an ignor$ field ( m$ic9e f a *aotic to a sci5tific basis40 ,possibly ! foll[+ te/imonial publi%$ by ,dr4 ,abrams z typical ( _m receiv$1 & cr$it$ to 8,dr4 ,h5ry ,/acy ,dodge1 ,ri*mond1 ,va410 may expla9 ! field t 8,spondylo!rapy0 is to cov]4 ,incid5tally 8,dr40 ,dodge is li/$ 9 ! ,ri*mond telephone directory z a *iropractor3 8,i h be5 9 practice = fifte5 ye>s 9 ,*iropractic & t5 ye>s an ,o/eopa? & ,i wi% to say t dur+ ! la/ ?ree ye>s ,i h receiv$ m g5u9e & s9c]e satisfaction f ! application ( ,spondylo!rapy ?an all o!r me?ods comb9$4 ,my success 9 ga/rology alone is wor? _m times ! co/ ( ! in=mation40 ,m rec5tly1 ,dr4 ,abrams has adv]tis$ t he gives a 8c\rse0 9 ,spondylo!rapy 9 ,san ,francisco1 beg9n+ on ! fir/ ( ea* mon?4 ,! c\rse la/ f\r weeks4 8,! honor>ium = ?is c\rse is #bjj4jj40 ,9 #aiab an organization 0 creat$ devot$ to ?is new !rapeutic me?od3 ! 8,am]ican ,association = ! ,/udy ( ,spondylo!rapy40 ,lat] ,dr4 ,abrams 0 made ,honor>y ,presid5t4 ,:e!r ! organization is /ill viable we d n "k4 ,,electronic ,,reactions ,,( ,,abrams ,9 addition to 8,spondylo!rapy10 ,dr4 ,abrams has also evolv$ :at he calls ! 8,electronic ,reactions ( ,abrams40 ,^! are said to make possible long-di/ance diagnoses1 x be+ necess>y only to s5d a few drops ( blood tak5 f ! pati5t & all[$ to dry on a slide4 ,!re are1 x seems1 c]ta9 in/rum5ts & devices us$ 9 ! p]=mance ( ^! diagno/ic feats4 ,by means ( ! 8,electronic ,reactions0 ,dr4 ,abrams 7:ile admitt+ ! protective factor ( vacc9ation aga9/ smallpox7 has discov]$ t practically all ! vacc9es obta9$ f reliable firms yield ! reaction 78electronic te/s07 ( cong5ital syphilis1 & t _m ( !m also yield ! reaction ( tub]culosis & ( /reptococci & /aphylococci4 ,fur!r1 8f ! cicatrices ( all vacc9at$ p]sons1 "o c always elicit a reaction ( cong5ital syphilis & 9 e>ly sc>s a tub]cul\s reaction40 ,dr4 ,abrams also decl>es t expos+ vacc9e virus = t5 m9utes to blue light w de/roy ! syphilitic1 /reptococcic & /aphylococci reactions & expos+ x = ! same p]iod to yell[ light w de/roy ! tub]cul\s reaction4 ,"o ( ,dr4 ,abrams' disciples--,sir ,james ,b>r--frequ5tly quot$ ) evid5t satisfaction1 decl>es t f a fre% sample ( blood spread ov] f\r squ>e in*es ( :ite blott+ pap]1 8,dr4 ,abrams c diagnose ! sex1 race & disease ( ! pati5t40 ,h[ev]1 !re are c]ta9 precautions t mu/ be tak53 ,! pati5t %\ld face ,we/1 8! blood %\ld be tak5 9 a subdu$ light & !re %\ld be no /rong r$ or yell[ color+ mat]ial 9 ! room40 ,9 v>i\s places ,dr4 ,abrams has assev]at$ t 8if splan*o-diagnosis is approa*$ ) a prejudic$ m9d1 x is bett] n to attempt x1 = !re are #8none s bl9d z ^? t w n see4'0 ,dr4 ,abrams f\nd$ & edits ,physico-,cl9ical ,m$ic9e4 ,x is publi%$ by 8,physico-,cl9ical ,co40 at #bace ,sacram5to ,/41 ,san ,francisco--! address1 accord+ to ! telephone directory1 ( ,dr4 ,abrams' resid5ce4 ,x is a qu>t]ly 8,devot$ to ! ,/udy ( ! ,electronic ,reactions ( ,abrams & ! ,visc]al reflexes ( ,abrams1 9 ! ,diagnosis1 ,treatm5t & ,pa?ology ( ,disease40 ,s+le copies1 "o doll>2 by ! ye>1 two doll>s4 ,! publication is1 app>5tly1 n ent]$ z second class matt]1 9 fact1 presumably1 x c\ld n be1 z x seems obvi\sly to be an adv]tis+ affair4 ,ea* issue conta9s mat]ial deal+ ) 8,spondylo!rapy10 8,splan*no-,diagnosis10 8,electronic ,reactions0 & o!r discov]ies & !ories ( ,dr4 ,abrams4 ,9 x also is publi%$ a li/ ( 8,"s rec5t visitors at ,dr4 ,abrams' laboratory10 ! names & addresses ( ! 8,lessees ( ,oscillocla/0 7ab\t :i* m lat]71 te/imonials = ,dr4 ,abrams1 etc4 ,( c\rse1 x c>ries adv]tisem5ts ( ,dr4 ,abrams' 8,physico-,cl9ical ,laboratory0 7also at #bace ,sacram5to ,/47 & 8 8,practical ,c\rses 9 ,spondylo!rapy & ,electronic ,diagnosis & ,treatm5t0 7#bjj 9 advance74 ,"s ( ! devices ( ,dr4 ,abrams are also adv]tis$4 8,no app>atus sold on cr$it4 ,t]ms ca%40 ,among ^! are3 8,dr4 ,abrams' ,electrodes = ,electronic ,diagnosis #f4jj 8,biodynamomet] #cf4jj 8,dr4 ,abrams' ,reflex ,set #cf4jj 8,dr4 ,abrams' ,electro-,concuss] #abj4jj0 ,,! ,,oscillocla/ ,b :at seems to be ! out/&+ piece ( app>atus1 devis$ or inv5t$ by ,dr4 ,abrams1 ! pice de resi/ance1 z x 71 ( physicocl9ical diagnosis & treatm5t1 is ! 8,oscillocla/40 ,?is device is n = sale4 ,x c be _h only on lease4 ,! fir/ paym5t is #bjj or #bej1 accord+ to :e!r x is wir$ = alt]nat+ or direct curr5t4 ,!n !re is a mon?ly paym5t ( #e4 ,dr4 ,abrams publi%es a li/ ( m ?an #acj m5 :o h leas$ "o or m 8,oscillocla/s40 ,sir ,james ,b>r's "n heads ! li/4 ,accord+ to ,dr4 ,abrams1 ! 8,oscillocla/0 owes its conception to ! !rapeutic pr9ciples he advocates4 ,^!1 9 "p1 are3 8#a4 ,physiologic ph5om5a are manife/ations ( electronic en]gy4 8#b4 ,pa?ologic ph5om5a are manife/ations ( p]turb$ electronic en]gy4 8#c4 ,! en]gy 9 heal? & disease has an inv>iable & def9ite rate ( vibration 7det]m9able by ! electronic reactions74 8#d4 ,specific drugs possess a l vibratory rate z ! diseases = :i* !y are effective4 8,^! l vibratory rates 7hemovibrations7 ( drugs owe _! effici5cy to _! inh]5t radioactivity4 ,?us1 an obsolete drug l gamboge pa9t$ on ! *e/ 9 incipi5t tub]culosis w effect a symptomatic cure )9 a few weeks4 ,gamboge possesses ! same vibratory rate z tub]culosis4 ,our conception t drug action is dep5d5t on direct cellul> contact is ?us demoli%$4444 8#e4 ,all =ms ( en]gy :e!r d]iv$ f heat1 electricity or magnetism may be made to yield diff]5t rates ( vibration & ^! rates correspond+ to ! diseases are utiliz$ = _! de/ruction40 ,if "o accepts "o ( ,dr4 ,abrams' !ories1 ! possibilities ( su* a piece ( ma*9]y z ! 8,oscillocla/0 w\ld seem to loom l>ge1 n only 9 !rapeutics1 b also 9 economics4 ,all "o ne$s to d1 accord+ to ,dr4 ,abrams1 is to asc]ta9 8! vibration rate ( a drug0 & !n to sub/itute ! same vibration z produc$ by ! 8,oscillocla/40 ,?us1 if "o sub/itutes ! 8vibratory rate ( atrop90 = ! drug itself 8! m\? dries or ! subject feels z if x 7 puck]$40 ,conv]sely1 if y swit* ! 8,oscillocla/0 to ! piloc>p9 vibratory rate1 !re is a copi\s fl[ ( saliva4 ,,!rapeutic ,,results ,,) ,,oscillocla/ ,:at "s ( ! lessees ( ! oscillocla/ are accompli%+ 7if we are to believe ! cl9ical reports publi%$ 9 ,physico-,cl9ical ,m$ic9e7 may be ga!r$ f ! foll[+ quotations3 8,woman1 ,age #eb4--;,diagnosis ( acquir$ syphilis made by "o ( our mo/ em95t cl9icians4 787 ,abrams te/ %[$ tub]culosis ( ! apex ( ! "r lung4 ,no syphilis4 ,f\rte5 treatm5ts ) ! ,oscillocla/ at #e4 ,pati5t ga9$ f\rte5 p\nds 9 ?ree weeks4 ,n[ 9 p]fect heal?40 8,me*anic1 ,age #bb4--;,acute acquir$ syphilis4 ,g5]al eruption1 ?roat1 m\? symptoms & *ancre4 ,?irte5 treatm5ts ) ! ,oscillocla/ at #c1 & spl5ic /]ilization only4 ,complete abatem5t ( all symptoms40 8,woman1 ,age #db4--,/rep infection ( ! second upp] cuspid too? ( ?ree ye>s' /&+4 ,well develop$ s9us4 ,regul> dis*>ge ( pus4 ,eight treatm5ts ) ! ,oscillocla/ at #b4 ,cl9ically cur$40 8,canc] ( ! pylorus & pylorectomy execut$ at ! ,mayo ,cl9ic4 ,lat]1 vomit+1 sev]e pa9s1 loss 9 weight1 etc4 ,aft] ! ?ird treatm5t ) 8,oscillocla/0 pa9s ceas$ &1 aft] #ad treatm5ts1 %e 0 well & cont9u$ s :5 ,i la/ saw h]40 8,canc] ( ut]us4 ,inop]able4 ,sev]e ut]9e hemorrhages4 ,electrode ( ,oscillocla/ to c]vix & hemorrhage ceas$ aft] second treatm5t4 ,aft] #ad treatm5ts ! pati5t decl>$ %e 0 well4 ,ano!r case ( ! same "* 0 foll[$ by equally good results40 ,,economic ,,results ,,) ,,oscillocla/ ,x also seems to be a great bus9ess-gett]1 z ! foll[+ te/imonials publi%$ by ,dr4 ,abrams %[3 8,! ,oscillocla/ has d\bl$ my bus9ess40--,s4 ,k+1 ,m4,d4 7,pa474 8,i am do+ good "w ) ! ,oscillocla/ 9 ,t4 ,b4 & :5 ,i get m room ,i %all want ano!r ma*9e40--,h4 ,mi*5] 7,kas474 8,we are swamp$ ) "w & our ?ree cord ,oscillocla/ is work+ to full capacity4 ,we are /ill a/oni%+ ! incr$ul\s & keep+ busy4 ,we mu/ h ano!r ,oscillocla/ at once = !re are s _m "h :o dem& treatm5t40--,w4 ,p4 ,my]s1 ,m4,d4 7,cal474 ,,! ,,electrobioscope ,m rec5tly1 ,dr4 ,abrams has ext5d$ 8 obs]vations & exp]im5ts1 us+ :at app>5tly is a modification ( ! old fa%ion$ pi? ball susp5d$ by a silk ?read f a rubb] rod ) :i* we all exp]im5t$ dur+ our high s*ool days4 ,?is device ,dr4 ,abrams has call$ ! 8,electrobioscope40 ,x is = sale by ! ,physico-,cl9ical ,co4 ,! 8,electrobioscope10 9 addition to do+ _m o!r ?+s1 has demon/rat$ 7to ,dr4 ,abrams7 ! 8sexuality ( numb]s & s\nds40 ,?us1 if ! pi? ball is *>g$ negatively & ! numb]s #a to #i are m>k$ on a n>r[ bo>d & ! v[els & consonants are m>k$ on ano!r bo>d1 x w be f\nd--/ill accord+ to ,dr4 ,abrams--t ev5 numb]s repel ! pi? ball :ile odd numb]s attract x4 ,v[els repel & consonants attract4 8,a female hair repels & a male hair attracts40 ,f ^! data ,dr4 ,abrams d$uces t 8ev5 numb]s & v[els are female & odd numb]s & consonants are male40 ,! value ( music z a !rapeutic ag5t is briefly t\*$ on by ,dr4 ,abrams & we are told t ! ov]ture ( 8,tannhus]0 w increase ! pulse rate :]eas 8,m$itation0 dim9i%es blood pressure & pulse rate4 8,9 dogs1 music augm5ts elim9ation ( c>bonic acid & increases ! consumption ( oxyg540 ,love1 says ,dr4 ,abrams1 8is dep5d5t ^u matt] 9 vibration & ! passional compon5t has a wave metric index ( #ad 9 bo? sexes40 ,9 ref]r+ to leg5d>y lore1 ,dr4 ,abrams app>5tly assigns a sci5tific basis = ! belief among ! bucolic t c>ry+ ar\nd a potato has !rapeutic virtue4 ,?us3 8,a cut potato 7c>ri$ on ! p]son7 prev5ts elicitation ( ! /oma* reflex :5 ! negative pole ( a b>-magnet is pres5t$ to ! /oma* region :]eas ! positive pole w evoke dulness40 ,x seems also t ! 8rheumatic r+s0 ( iron 8:5 worn yield a neutral en]gy :i* prev5ts ! elicitation ( ! /oma* reflex by ei!r pole ( a b>-magnet40 ,we le>n1 too1 t ! div9+ rod 8no long] belongs to occultism b is entitl$ to consid]ation z a sci5tific fact40 ,dr4 ,abrams also has inve/igat$ me?ods :]eby ! sex ( ! fetus may be diagnos$4 ,9 ! human ^! inve/igations h1 app>5tly1 be5 s limit$ z to p]mit only t5tative conclusions4 ,9 ! case ( eggs ( ! dome/ic f[l1 ,dr4 ,abrams reports t ) f\r eggs t yield$ negative pol>ity1 ! result ( incubation 0 f\r h5s4 ,( five eggs yield+ a positive pol>ity only two hat*$1 "o 0 a h5 & "o a roo/]1 giv+ an 8error 9 obs]vation40 ,?ree eggs te/$ yield$ neutral pol>ity & 8z pr$ict$ ! eggs 7 /]ile40 ,9 case ( an egg yield+ a negative 7female7 pol>ity 8an attempt 0 made to rev]se ! sex by pa9t+ "o end ( ! egg ) a yell[ color+ mat]ial40 ,! result 0 a roo/]4 ,mu* m might be writt5 ab\t :at "o ( our correspond5ts calls ! wond]ful ?+s !y are do+ 9 ! ,we/1 b space =bids4 8,nei!r ! fury ( tongue10 says ,dr4 ,abrams 9 ! preface to 8 book1 ,new ,concepts 9 ,diagnosis & ,treatm5t1 8nor ! trucul5ce ( p5 c discr$it ! au?or's obs]vations :i* are capable ( analyzation & demon/ration40 ,if !re is any sci5tific f\ndation = ! m>vels t ,dr4 ,abrams s picturesquely features1 ! sci5tific _w has n yet f\nd x out6--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,m>* #be1 #aibb47 ,dr4 ,abrams' ,graduation ,9 ?is dep>tm5t ( ,! ,j\rnal = ,m>* #be appe>$ an article on ,dr4 ,alb]t ,abrams & "s ( 8 discov]ies4 ,we h n[ receiv$ a lett] f a physician1 :o asks t 8 "n be n publi%$1 read+3 8,to ! ,editor3--,i notice 9 y\r article on ,alb]t ,abrams ! /atem5t t he 0 born 9 #ahfd & receiv$ 8 degree ( ,m4,d4 9 ,heidelb]g #ahhb2 if ^! data are furni%$ by himself & n a typographical error--?\gh ,i f9d ! same data 9 ! ,am]ican ,m$ical ,directory = #aiaf--!n x is high "t t "s bo>d ( c5sors %\ld make a c>eful exam9ation ( 8 cr$5tials4 8,anybody1 l myself1 :o is acqua9t$ ) m$ical matt]s 9 ,g]many kn[s t x is prepo/]\s to assume t anybody c\ld obta9 ! degree ( ,m4,d4 9 any ,g]man univ]sity at ! age ( #ah ye>s4 ,m4 ,d41 ,leipzig40 ,eighte5 is r "y to receive an ,m4,d4 degree f ,heidelb]g6 ,by aga9 go+ ov] ! v>i\s s\rces ( in=mation available ! foll[+ data 7 collect$3 ,9 ,polk's ,m$ical ,directory = #ahhf ,dr4 ,abrams' "n appe>s z a graduate ( ! ,univ]sity ( ,heidelb]g1 #ahhb1 & ( ,coop] ,m$ical ,college 9 #ahhc4 ,! records we h f ^! two in/itutions confirm ^! dates4 ,! ye> ( ,dr4 ,abrams' bir? seems less cle>4 ,9 ! e>ly "p ( #aijb ! ,am]ican ,m$ical ,association s5t ,dr4 ,abrams a blank = him to fill out = a p]man5t record4 ,?is 0 return$ 9 due c\rse &1 accord+ to x1 ,dr4 ,abrams 0 born 9 ,san ,francisco ,dec4 #h1 #ahfc4 ,?is same date appe>s 9 v>i\s editions ( 8,:o's ,:o 9 ,am]ica40 ,a blank s5t by ! ,a4 ,m4 ,a4 ,directory ,dep>tm5t to ,dr4 ,abrams 9 #aijh ask+ = a p]sonal biographical report 0 return$ ,aug4 #bj1 #aijh2 x gave ,dr4 ,abrams' date ( bir? z ,dec4 #h1 #ahfd4 ,a simil> blank s5t 9 ! e>li] "p ( #aiji 0 return$ giv+ ! same bir? date4 ,we le>n1 h[ev]1 t an affidavit execut$ 9 #aiag /ates t ,alb]t ,abrams 0 born 9 ,san ,francisco ,dec4 #h1 #ahfb4 ,j h[ long ,dr4 ,abrams att5d$ ,heidelb]g ,univ]sity be=e he 0 grant$ ! ,m4,d4 degree1 we d n "k4 ,app>5tly1 at t "t ! /&>ds = admission to t in/itution 7 n especially sev]e & ! l5g? ( "t "o w\ld h to att5d be=e be+ admitt$ to an exam9ation seems to h dep5d$ on ! educational cr$5tials t ! matriculant (f]$4 ,:at cr$5tials ,dr4 ,abrams submitt$1 we d n "k4 ,assum+ t ! e>lie/ date 7#ahfb7 repres5ts ,dr4 ,abrams' date ( bir?1 he c\ld h be5 b tw5ty ye>s old :5 he receiv$ 8 ,m4,d4 f ,heidelb]g4 ,?is indicates a precocity t might h =eca/ ,dr4 ,abrams' lat] a*ievem5ts4 ,?r\gh\t ! records ( ,dr4 ,abrams' educational cr$5tials !re appe>s ! /atem5t t he also graduat$ f ! 8,univ]sity ( ,portl&0 9 #ahib1 receiv+ ! degree ( ,a4,m4 ,f ref]5ces available we h be5 unable to f9d any record ( a 8,univ]sity ( ,portl&40--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,april #h1 #aibb47 ,a ,def5se by ,upton ,s9clair ,a some:at volum9\s lett] has be5 receiv$ f ,mr4 ,upton ,s9clair1 :i* is a def5se ( ,dr4 ,alb]t ,abrams ( ,san ,francisco4 ,we publi% ,mr4 ,s9clair's lett] because we believe x is writt5 9 hone/y & s9c]ity--& because ,! ,j\rnal read]s w enjoy x6 ,x is wor? m5tion+ 9 ?is connection t ,mr4 ,s9clair 9 8 late/ book devotes a few pages to a eulogy ( ,dr4 ,abrams & 8 me?ods4 ,?is mat]ial has n only be5 reproduc$ by ,dr4 ,abrams 9 8 8h\se organ0 ,physico-,cl9ical ,m$ic9e b is repr9t$ 9 leaflet =m & is be+ di/ribut$ by "s ( ! individuals :o are exploit+ ! ,abrams me?ods4 ,su* repr9ts h be5 s5t to ?is (fice by bo? laym5 & physicians4 ,,mr4 ,,s9clair',s ,,lett] ,to ! ,editor4--,a few weeks ago y publi%$ an article deal+ ) ! discov]ies or claims ( ,dr4 ,alb]t ,abrams ( ,san ,francisco4 ,i happ5 to be att5d+ ,dr4 ,abrams' cl9ic at ! "t & h discuss$ ?is article ) him at "s l5g?4 ,dr4 ,abrams foll[s ! policy ( ignor+ attacks on 8 "w1 tak+ ! view t 9 ! long run1 ! man :o cures disease makes 8 way 9 ! _w 9 spite ( all opposition4 ,h[ev]1 x is easy to see t he has be5 deeply hurt by ?is attack on 8 reputation1 & z "o ( 8 fri5ds & mo/ ard5t admir]s ,i am tak+ ! lib]ty ( address+ a lett] to y4 ,i d n "k if ! rules ( y\r publication p]mit int]v5tion 9 m$ical affairs by a m]e layman4 ,p]mit me to introduce myself z a layman :o = "s tw5ty ye>s tri$ fai?fully to be cur$ ( v>i\s diseases by _m doctors ( ! be/ reputation 9 _m p>ts ( ! _w1 & fail$2 & :o1 !re=e1 0 compell$1 z a matt] ( self-protection1 to look into ! "q ( heal? = himself4 ,i h read s _m diff]5t k9ds ( books on heal? & made s _m exp]im5ts ( my own t n[adays :5 ,i meet ) a gr\p ( physicians ,i f9d t be=e long !y come to accept me z "o ( !mselves4 ,y may n g t f>1 b at lea/ y may be s g5]\s z to all[ me to tell y a little ( :at ,i h se5 dur+ ! "t ,i h sp5t 9 ! cl9ic ( ,dr4 ,alb]t ,abrams4 ,i obs]ve t 9 ! c\rse ( y\r two page article deal+ ) ?is subject1 y n[h]e h any?+ to *>ge aga9/ ,dr4 ,abrams1 nor d y %[ t y h inve/igat$ 8 "w4 ,y consid] t all y h to d is to quote ,dr4 ,abrams' own words z to :at he c d1 & t ^! words refute !mselves4 ,italics our4--,ed44 ,also y quote ,dr4 ,abrams' s*$ules ( prices1 & imply t 8 motives are m]c5>y4 ,i w take up ^! two que/ions "o at a "t4 ,,:at ,,dr4 ,,abrams ,,c ,,d ,fir/1 z to :at ,dr4 ,abrams c d3 ,i h be5 "h & h se5 him d all t he claims to d4 ,!re=e1 y w und]/& t ?is portion ( y\r argum5t does n produce mu* impression on me4 ,i m]ely say to y1 :y d y n come & see1 or :y d y n s5d "s reliable repres5tative to see--be=e y take x = grant$ t ,abrams is a knave or a lunatic8 ,?is man is n m]ely a colleague ( y\rs2 he is a fell[ ( ! ,royal ,m$ical ,society ( ,great ,brita9 ,we "k ( no su* society4--,ed4 & surely he 0 entitl$ to a little elem5t>y c\rtesy f y4 ,:y did y n at lea/ write to him & p]mit him to put be=e y a little ( 8 evid5ce on ! g5u95ess ( 8 "w8 ,y admit t he is a graduate ( ! ,univ]sities ( ,heidelb]g & ,/an=d2 ,dr4 ,abrams is n a graduate ( 8,/an=d40--,ed4 y admit t he 0 graduat$ f ,heidelb]g at ! age ( tw5ty4 ,x happ5s t ?is 0 ! y\nge/ & rema9s ! y\nge/ age at :i* any man has tak5 a ,doctor's ,degree at t ,univ]sity 9 a hundr$ ye>s4 ,if y _h inquir$ fur!r y might h le>n$ t t5 ye>s ago ,abrams 0 "o ( ! mo/ respect$ physicians 9 ,san ,francisco4 ,:at has he done s9ce to =feit ! honors ( a lifetime8 ,all t he has done is to %ut himself up 9 8 laboratory & make ! mo/ revolution>y discov]ies ( ?is or any o!r age2 & n[ :5 he em]ges & (f]s ?is "w to ! _w1 y c ?9k ( no?+ to d b je] at him4 ,i sp5t two weeks 9 8 cl9ic2 !n ,i took six mon?s to write to 8 physicians all ov] ! c\ntry1 & to exp]im5t ) 8 cures on a great numb] ( my fri5ds4 ,italics aga9 ours4--,ed4 ,n[ ,i am sp5d+ ano!r two weeks 9 8 cl9ic1 & ,i v5ture to /ake :atev] reputation ,i h1 or hope to h 9 ?is _w1 ^u ! /atem5t t ,alb]t ,abrams has discov]$ ! great secret ( ! diagnosis & cure ( all ! major disease4 ,aga9 we mu/ italicize4--,ed4 ,he has prov5 by diagnos+ ) ! taps ( 8 own s5sitive f+] tips ov] #ae1jjj p1 & my inve/igation conv9ces me t he has cur$ ov] #ie p] c5t4 ( ^! :o h tak5 8 treatm5ts4 ,moreov]1 he has taught 8 me?od to #bjj or #cjj o!r physicians1 & "s #hj p] c5t4 ( ^! h submitt$ to me answ]s to a que/ionnaire 9 :i* !y claim ?\s&s ( cures4 ,y may say1 p]haps1 t ,i am n compet5t to judge ( cures4 ,= ! sake ( argum5t1 ,i w grant t2 b ,i ass]t t ,i am compet5t to judge ( physicians1 = ,i h te/$ sev]al score ( !m1 & if ,i ev] knew a devot$ sci5ti/ & a great humanit>ian1 x is ,alb]t ,abrams4 ,9 8 cl9ic ,i h met p]haps a hundr$ physicians1 & ,i v5ture to ass]t t a numb] ( ^! are m5 bo? ( integrity & capacity1 & :5 ,i ask$ !m :y !y came1 ,i got inv>iably "o answ]3 8,because ,i s5t him blood specim5s & ,i f\nd t inv>iably he s5t me a correct diagnosis40 ,n once1 b at lea/ two score times1 ,i h se5 ,alb]t ,abrams take a blood specim5 br\ght to him1 )\t ev5 ! "n ( ! pati5t1 & he>d him diagnose canc] or s>coma1 & f ! blood specim5 locate ! gr[? ,,precisely ,,to ,,an ,,in*4 ,italics fail "o "h6--,ed4 ,!n ,i h se5 ! pati5t1 an entire /rang] to ,abrams1 br\ght into ! cl9ic & exam9$1 n m]ely by ,abrams1 b by a score ( o!r physicians1 & ! gr[? f\nd precisely at ! spot indicat$4 7,?is 0 done twice betwe5 ! "t :5 ?is lett] 0 dictat$ & ! "t :5 x 0 transcrib$47 ,?ree times1 ye/]day1 ,i saw a diagnosis made ( syphilis & ! pati5t br\ght 91 & all ! /&>d reactions demon/rat$4 ,i h se51 n once1 b hundr$s ( times1 tub]cul> lesions diagnos$ & locat$ f ! blood specim5 & ! pati5t br\ght 9 & ! condition demon/rat$ by p]cussion4 ,all ^! ?+s are go+ on day aft] day4 ,!y are be+ done 9 o!r cl9ics 9 sev]al score ( cities1 & y may h ! addresses = ! ask+4 ,:y d y n ask8 ,we h "s su* addresses 9 ! ,propag&a files4--,ed4 ,,! ,,economic ,,elem5t ,i take up ! second criticism1 t ,alb]t ,abrams is m]c5>y4 ,he *>ges #bjj4jj = ! cl9ical c\rse1 :i* may la/ z long z ! physician wi%es4 ,x seems to me t t price is to be judg$ some:at 9 relation to :at he has to tea*4 ,he ma9ta9s a l>ge e/abli%m5t2 he has ne$ ( _m assi/ants1 & exp5sive app>atus = 8 rese>* "w4 ,he *>ges = ! use ( 8 oscillocla/ a deposit ( #bej4jj1 & a r5tal ( #e4jj p] mon?4 ,! =m] item cov]s ! co/ ( manufactur+ ! ma*9e1 & ! second item mu/ be comp>$ ) ! fact t a great numb] ( physicians :o are us+ ?is in/rum5ts are today enjoy+ incomes ( f #a1jjj4jj to #b1jjj4jj p] week4 ,once m1 italics6--,ed4 ,a few weeks ago ,i visit$ a physician :o told me he _h treat$ ?irty-two pati5ts t day ) 8 "o in/rum5t1 & t 8 income 0 ov] #a1cjj4jj = t week1 & ,i c\ld "n sev]al :o h giv5 simil> acc\nts4 ,x may be1 ( c\rse1 t y w say !y %\ld n *>ge s mu*4 ,! av]age *>ge is ab\t #bjj4jj = a gu>ante$ cure ( su* diseases z syphilis1 tub]culosis1 canc] & s>coma4 ,italics our aga94--,ed44 ,d y "k anyone :o w gu>antee to cure a canc] or s>coma at any price8 ,no6--,ed4 ,i am sure y w agree ) me t x w\ld be possible to f9d physicians :o w\ld be will+ to put up _m hundr$s ( doll>s to gu>antee t nei!r canc] nor s>coma c at ! pres5t "t be cur$ except by op]ation4 ,& ,i c recall _m cases 9 my lifetime :5 ,i paid hundr$s & ev5 ?\s&s ( doll>s to be cur$ ( diseases by ! m$ical pr(ession1 & ,i am unable to recall a s+le case :]e ,i 0 ev] cur$ ( any?+4 ,/ill ?is ne$ n be an indictm5t ( sci5tific m$ic9e4--,ed4 ,f9ally1 z reg>ds to ! subject ( m]c5>y motives1 p]mit me to /ate t ,i h 9 my possession a lett] f ,dr4 ,abrams /at+ t :at he desires is to h e/abli%$ an in/itute = ! purpose ( mak+ 8 "w kn[n to ! _w1 & t if su* an in/itute is e/abli%$ he is prep>$ to give up all 8 o!r "w & devote all 8 "t1 )\t comp5sation1 to ! in/itute4 ,fur!rmore1 he is will+ to furni% 8 in/rum5ts )\t *>ge to any m$ical in/itution :i* reque/s !m4 ,)9 ! la/ few days1 on acc\nt ( ! enorm\s numb] ( blood specim5s br\ght into 8 cl9ic1 ,dr4 ,abrams has sign$ 9 my pres5ce1 & is prep>$ to issue a /atem5t to ! effect t 8 *>ge = exam9+ blood specim5s is to be rais$ f #aj4jj to #be4jj & all *ecks are to be made payable to a ,tru/ ,fund :i* is to be imm$iately e/abli%$1 = ! purpose ( f\nd+ ! in/itution above ref]r$ to4 ,i d n see h[ ! m$ical pr(ession c ask = m ?an ?is2 b if y d1 ,i %\ld be pleas$ to receive y\r sugge/ions & transmit !m to my fri5d4 ,,an ,,old ,,/ory ,n[1 ?is failure to recognize a great m$ical discov]y is an old /ory4 ,x 0 ! exp]i5ce ( ,h>vey ,we knew poor ,h>vey w\ld be dragg$ into ?is4--,ed41 ( ,j5n] & ( ,li/]4 ,b ! _w moves on1 & m5's bra9s %\ld improve1 & x %\ld be possible to %ort5 ! "t ( p]secution :i* ! great pione]s ( sci5ce h to suff]4 ,i put to y ?is simple proposition3 ,s5d a reliable man ( sci5ce to ! cl9ic ( ,alb]t ,abrams1 & let him /ay !re z long z he pleases & see all t he wi%es to see1 & !n s5d y a report1 & if x indicates t y h blund]$ 9 y\r condemnation1 be hone/ & say s1 & save y\r pr(ession f ano!r black m>k aga9/ its "n4 ,upton ,s9clair1 ,pasad5a1 ,cal4 ,comm5t ,a te/imonial is ( value to ! ext5t t ! p]son giv+ x is an au?ority on ! subject on :i* he te/ifies4 ,:5 ,mr4 ,s9clair te/ifies on socialism we may li/5 respectfully1 believ+ him compet5t to express an op9ion2 b :5 ,mr4 ,s9clair gives a te/imonial on c]ta9 biz>re me?ods ( int]pret+ difficult & obscure problems 9 m$ic9e1 he leaves u cold4 ,mr4 ,s9clair says t he has sp5t "t 9 ,dr4 ,abrams' cl9ic & is wond]fully impress$ ) ,dr4 ,abrams' a*ievem5ts4 ,s is ! small boy impress$ ) ! m>vel\s facility ) :i* ! magician extracts ! :ite rabbit f ! silk hat4 ,mr4 ,s9clair is conv9c$ 8t ,alb]t ,abrams has discov]$ ! great secret ( ! diagnosis & cure ( all ! major diseases40 ,! small boy is equally conv9c$ t ! pre/idigitator has solv$ ! my/]y ( produc+ sn[ :ite bunnies f airy no?+s4 ,great /ore seems to be plac$ by ,mr4 ,s9clair on ! favorable reports t he obta9$ f ^? :o are reliev+ ! public--( f #a1jjj to #b1jjj a week--by ! ,abrams me?ods ( diagnosis & treatm5t4 ,:at k9d ( evid5ce did he expect to get f su* obvi\sly ex p>te s\rces8 ,mr4 ,s9clair's navet may be *ildlike1 b x is n sci5tific4 ,:ile ! significance ( ! /atem5t may n be app>5t to ,mr4 ,s9clair1 x is a fact t :5 ! names ( ! "o hundr$ or m lessees ( ! ,abrams 8,oscillocla/0 7 *eck$ up x 0 f\nd t a numb] ( ^! individuals 7 already 9 ! ,propag&a files 9 "s o!r connection4 ,t ^! disciples ( ,abrams1 :o are 8enjoy+ incomes ( f #a1jjj to #b1jjj a week10 %\ld speak favorably ( ! ,abrams me?od 0 inevitable6 ,"s ye>s ago ,upton ,s9clair wrote a book on 8 7at t "t7 panacea = human ailm5ts4 ,x 0 ! 8,fa/+ ,cure40 ,at t "t he told ( individual acqua9tances suff]+ f v>i\s ailm5ts3 "o 0 8dy+ ( kidney tr\ble02 ano!r 0 89 ! hospital f n]v\s breakd[n02 /ill ano!r _h 8only a ye> to live10 :ile a f\r? 0 8a n]v\s wreck1 crav+ = dea?40 ,( ^! ,mr4 ,s9clair said at ! "t3 8,& !re is n "o ( ^! p :om ,i c\ld n cure if ,i _h him alone = a c\ple ( weeks40 ,,mr4 ,,s9clair ,,& ,,! ,,m$ical ,,pr(ession ,at t "t ,mr4 ,s9clair 0 greatly p]turb$ at ! attitude ( ! m$ical pr(ession t[>d 8 dictum t 8! fa/ is ,nature's rem$y = all diseases40 ,!re 0 j "o physician 8:o 0 really int]e/$40 ,?is man liv$ 89 an out ( ! way t[n 9 ,arkansas0 & ask$ ,s9clair to 8let him pr9t sev]al ?\s& copies ( ! article 9 ! =m ( a pamphlet to be di/ribut$ among 8 pati5ts40 ,z ,mr4 ,s9clair said at ! "t1 8"o s+le m9d among all ! #adj1jjj physicians1 op5 to a new tru?60 ,& ?is 8op5 m9d10 t ( a man :o 0 practic+ 9 a small t[n 9 ,arkansas & ne$$ 8sev]al ?\s& copies0 ( ! ,s9clair article to di/ribute to 8 pati5ts6 ,aft] 8 8fa/+ cure0 exp]i5ce1 ,mr4 ,s9clair _h ! 8raw food0 fad--also ab&on$ 9 due "t4 ,9 "o ( 8 rec5t books 78,! ,brass ,*eck07 he ref]s to 8 outgr[n fads 9 ! foll[+ words3 8,i 444 0 will+ to try any?+ 9 ! hope ( solv+ ! heal? problem1 :i* ,i h s9ce realiz$ is insolvable--!re be+ no diet or sy/em ( any sort :i* w p]mit a man to ov]work ) impunity40 ,he /ates fur!r 9 ?is same connection3 8,i look back 9 retrospect & h n a little fun ov] my #8monkey diet' days40 ,:o %all say t t5 ye>s h5ce ,mr4 ,s9clair may n be able to look back1 good humor$ly1 9 retrospect1 to ano!r "t :5 he 0 8monkey+0 ) a subject t 0 beyond 8 k58--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,april #bi1 #aibb47 ,,acetylsalicylic ,,acid1 ,,n ,,aspir9 ,! ,c\ncil on ,ph>macy & ,*emi/ry publi%es a report 9 ?is issue giv+ its reasons = delet+ 8,aspir9-,bay]0 f ,new & ,non(ficial ,rem$ies4 ,9 ord] t a /&>d may be provid$1 ! drug acetylsalicylic is reta9$#bei 9 ,n4 ,n4 ,r4 "u its sci5tific "n1 acetylsalicylic acid1 aspir9 appe>+ z a synonym4 ,! attempt on ! "p ( ! ,bay] ,company to p]petuate ! monopoly x has _h = sev5te5 ye>s 9 ! ,unit$ ,/ates 0 briefly discuss$ editorially 9 ,! ,j\rnal1 ,aug4 #ab1 #aiaf4 ,we quot$ f ,pr9t]s' ,ink1 a magaz9e devot$ to adv]tis+1 9 "p z foll[s3 #bei ,see index = additional article4 8,! manufactur]s ( aspir9 are ab\t to laun* an ext5sive adv]tis+ campaign to cl9* ! m>ket z f> z possible be=e ! expiration ( _! pat5t rights next ye>4444 ,! purpose ( ! campaign is to id5tify ! product ) ! tradem>k ( ! ,bay] ,company & to ?is ext5t hamp] competition aft] ! expiration ( ! pat5t40 ,x is wor? :ile rem9d+ physicians ( ! privileges ! ,bay] ,company has enjoy$ = s _m ye>s1 ow+ l>gely to our inequitable & crude pat5t laws1 or to _! con/ruction4 ,fir/1 x %\ld be rememb]$ t practically no o!r c\ntry 9 ! _w1 n ev5 ! orig9al home ( ! prep>ation1 w\ld grant a pat5t on ei!r acetylsalicylic acid1 ! product1 or on ! process = mak+ t product4 ,! ,unit$ ,/ates grant$ bo?6 ,z a result1 = sev5te5 ye>s x has be5 impossible 9 ?is c\ntry = anybody except ! ,bay] ,company to manufacture or sell acetylsalicylic acid1 ei!r "u its *emical "n or "u any o!r "n4 ,nei!r 0 x possible = individuals1 hospitals or any o!r in/itutions to import x1 legally1 = _! own use4 ,ne$less to say1 ! ,am]ican p h be5 made to pay exorbitantly = ! monopoly our pat5t (fice grant$ ?is firm4 ,?ree or f\r ye>s ago ,! ,j\rnal1 ?r\gh ! ,am]ican consuls1 obta9$ in=mation reg>d+ ! price at :i* acetylsalicylic acid 0 sold 9 =eign c\ntries4 ,at t "t1 acetylsalicylic acid1 z 8aspir910 0 co/+ ,am]ican druggi/s--& ( c\rse ! ,am]ican public _h to pay /ill m = x--#dc c5ts an ounce4 ,j across ! bord] 9 ,canada x sold = "o-?ird ! price ask$ "h4 ,9 "s ( ! =eign c\ntries1 acetylsalicylic acid "u its sci5tific "n c\ld be pur*as$ by ! druggi/s ( ^? c\ntries at f "o-six? to less ?an "o-t5? ! price t x co/ ,am]ican druggi/s4 ,"h are "s ( ! figures3 ,au/ria-,hung>y #d c5ts an ounce ,holl& #d c5ts an ounce ,briti% ,isles #f c5ts an ounce ,norway #d c5ts an ounce ,d5m>k #d c5ts an ounce ,sw$5 #d c5ts an ounce ,france #d c5ts an ounce ,unit$ ,/ates #dc c5ts an ounce ,g]many #d c5ts an ounce ,n cont5t ) ! iron-b\nd monopoly :i* x _h be5 grant$ ?r\gh our pat5t laws1 ! company attempt$ fur!r to cl9* its exclusive rights by giv+ ! prep>ation a fancy "n1 8aspir910 & gett+ a tradem>k on ?is "n4 ,! pat5t on acetylsalicylic acid expires next mon? 7,febru>y1 #aiag74 ,aft] its expiration ! product1 & its me?od ( manufacture1 become common prop]ty4 ,am]ican manufactur]s w n[ be able to d :at manufactur]s 9 o!r c\ntries1 o!r ?an ! pat5tees1 h long be5 do+--make & sell acetylsalicylic acid4#bfj #bfj ,! ,bay] p may try to convey ! impression t 8,aspir90 is pure & reliable :]eas o!r br&s are n4 ,s9ce acetylsalicylic acid is a def9ite *emical comp\nd1 !re is no m likelihood ( ?is be+ sophi/icat$ ?an !re is ( qu99 be+ adult]at$4 ,fur!rmore1 ! ,c\ncil 9 accept+ acetylsalicylic acid = ,new & ,non(ficial ,rem$ies has provid$ /&>ds ( purity :i* w insure a uni=m product4 ,! br& ( "o firm--,p[]s-,weightman-,ros5g>t5 ,co41 ( ,philadelphia--has be5 accept$ by ! ,c\ncil on ,ph>macy & ,*emi/ry = inclusion 9 ,new & ,non(ficial ,rem$ies1 #aiag4 ,un=tunately1 x is extremely improbable t any ,am]ican manufactur] w m>ket acetylsalicylic acid "u ! "n aspir91 al?\gh we believe !y w\ld h a legal "r to d s4 ,! c\rts h held 9 relat$ in/ances t :5 a pat5t$ article has be5 kn[n dur+ ! life ( ! pat5t "u a tradem>k$ "n1 ) ! expiration ( ! pat5t ! "n z well z ! product becomes common prop]ty4 ,! classical 8,s+] ,sew+ ,ma*9e0 decision & ! lanol9 case are 9 po9t4 ,! ,bay] ,company1 ?r\gh a widespread newspap] adv]tis+ campaign1 seems to be attempt+ to p]petuate its sev5te5-ye> monopoly by lead+ ! public to believe t !re c be only "o br& ( g5u9e acetylsalicylic acid on ! m>ket--t made by ! ,bay] ,company4 ,! firm w1 ( c\rse1 cont9ue to manufacture & adv]tise ! product "u ! "n 8,aspir9-,bay]10 & w probably *>ge high prices = x1 z 0 ! case ) ph5acet9 7acetph5etid974 ,9 any ev5t1 physicians h]eaft] %\ld d :at = a long "t we h be5 advis+ %\ld be done1 namely1 prescribe ! comp\nd "u its sci5tific "n1 acetylsalicylic acid4 ,!y %\ld d ?is if = no o!r reason ?an t !y w\ld be us+ ! "n :i* c>ries ) x a rem9d] ( ! composition ( ! prep>ation4 ,( c\rse1 = ^? :o h be5 writ+ 8aspir90 x w be r difficult to write 8acetylsalicylic acid10 j z a qu>t] ( a c5tury ago x 0 difficult = ! physician ( t day :o _h be5 us+ ! copyright "n 8antifebr90 to write 8acet-anilid10 a "n :i* n[adays is easy1 ev5 = laym54--7,editorial f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #bj1 #aiag47 8,:at's 9 a ,"n80 ,"u ! caption 8,:at's 9 a ,"n80 ! curr5t 7,april7 issue ( ! ,j\rnal ( ,indu/rial & ,eng9e]+ ,*emi/ry has an editorial deal+ ) ! nom5clatures--common & propriet>y--( acetylsalicylic acid4 ,! editorial 0 prompt$ by an article by ,dr4 ,lee* pr9t$ 9 ! same issue4 ,reply+ to its own "q3 8,! answ] to ?is "q s f> z x applies to acetylsalicylic acid 7popul>ly kn[n z aspir97 is ! diff]5ce betwe5 eighty-eight c5ts1 ! price ! druggi/ mu/ pay = e "o hundr$ tablets ( ,bay] aspir91 & =ty c5ts1 ! co/ ( an equally pure ,am]ican product4 ,naturally1 ?is diff]5ce 9 co/ is pass$ on to ! individual consum]4 8,t no sci5tific ju/ification exi/s = ?is diff]5ce 9 co/ is cle>ly %[n 9 ! contribution by ,dr4 ,paul ,ni*olas ,lee*1 ( ! ,*emical ,laboratory ( ! ,am]ican ,m$ical ,association1 page #bhh ( ?is issue4 8,on ! o!r h&1 ! excess pr(it fully w>rants ! ext5sive & %rewdly-word$ adv]tis+ campaign n[ 9 progress1 a campaign :i* mu/ ev5tually fail1 because 9 ! fir/ place1 x is contr>y to ! prevail+ _s ( mod]n adv]tis+1 ! motive ( :i* is con/ructive r ?an de/ructive1 &1 9 ! second place1 x appeals m]ely to ! tempor>y ignorance ( ! public at l>ge1 & has no basis 9 fact4 8,we h be5 in=m$ t ! ,cu/odian ( ,ali5 ,enemy ,prop]ty has tak5 *>ge ( ! /ock int]e/s ( ali5 enemies 9 ! company conduct+ ?is propag&a4 ,surely ! ,cu/odian w n c>e1 ev5 9 a tru/ee capacity1 to cont9ue z a p>ticipant 9 a mislead+ campaign ^: sole purpose is ! p]petuation ( a monopoly hi!rto enjoy$ "u full pat5t protection40 ,! article to :i* ! editorial ref]s is a some:at te*nical "o giv+ ! f9d+s ( an exam9ation made1 at ! reque/ ( ! ,c\ncil on ,ph>macy & ,*emi/ry1 9 ! ,*emical ,laboratory ( ! ,am]ican ,m$ical ,association by ,paul ,ni*olas ,lee*1 ,ph4,d41 ( v>i\s ,am]ican br&s ( acetylsalicylic acid 7aspir974 ,! result ( ! inve/igation may be summ$ up briefly 9 ! /atem5t t !re are on ! ,am]ican m>ket1 made by ,am]ican firms1 sev]al br&s ( acetylsalicylic acid t are j z good z1 if n bett] ?an1 ! ,bay] product4 ,! ,j\rnal has call$ att5tion to ! mislead+ propag&a on ! "p ( ! ,bay] ,company 7,f>b5fabrik5 vorm4 ,fri$r4 ,bay] ,co471 9 its attempt to p]petuate ! monopoly grant$ "u our inequitable pat5t laws4 ,?is is done by convey+ ! inf]5ce t ! only pure acetylsalicylic acid on ! m>ket is t kn[n z 8,aspir9-,bay]40 ,physicians %\ld aga9 be rem9d$ ( ! facts 9 ! case ( aspir93 ,practically no o!r c\ntry 9 ! _w1 & c]ta9ly n ,g]many1 ! orig9al home ( aspir91 w\ld grant a pat5t ei!r on acetylsalicylic acid1 itself1 or ! process = mak+ x4 ,! ,unit$ ,/ates grant$ bo?6 ,z a result no "o 9 ?is c\ntry except ! ,bay] ,company c\ld = sev5te5 ye>s manufacture or sell acetylsalicylic acid ei!r "u its *emical "n or "u any o!r "n4 ,nor 0 x p]missible = hospitals or individuals to import x4 ,:ile ! monopoly held1 ! ,am]ican p 7 compell$ to pay f six to t5 times z mu* = acetylsalicylic acid z 7 ! p ( ,great ,brita91 ,france1 ,g]many1 ,au/ria-,hung>y1 ,d5m>k1 ,holl&1 ,norway or ,sw$54 ,at a "t :5 ,am]ican druggi/s 7 compell$ to pay #dc c5ts an ounce = acetylsalicylic acid z aspir91 j across ! bord] 9 ,canada x sold = ab\t "o-?ird ! price4 ,ab\t a ye> ago1 ! ,c\ncil on ,ph>macy & ,*emi/ry ann\nc$ t 8,aspir9-,bay]0 _h be5 delet$ f ,new & ,non(ficial ,rem$ies :ile ! sci5tific t]m acetylsalicylic acid 0 reta9$ along ) /&>ds to insure its quality4 ,! necessity = a /&>d becomes evid5t :5 x is rememb]$ t acetylsalicylic acid is n yet an (ficial drug1 & its purity1 !re=e1 is n subject to ! control ( ! f$]al ,food & ,drugs ,act4 ,x is wor? :ile at ?is "t to rem9d physicians t sev]al br&s ( acetylsalicylic acid 7aspir97 h be5 f\nd to comply ) ! /&>ds set by ! ,c\ncil on ,ph>macy & ,*emi/ry & h be5 admitt$ to ,new & ,non(ficial ,rem$ies4#bfa ,^!1 ( c\rse1 are !reby subject to ! control ( ! f$]al law to con=m to ! /&>d to :i* !y pr(ess4 #bfa ,! foll[+ br&s ( acetylsalicylic acid con=m to ! /&>ds ( ! ,c\ncil & are 9 ,new & ,non(ficial ,rem$ies3 8,aspir9-- ,l4 & ,f403 ,lehn ,f9k1 ,new ,york4 8,acetylsalicylic ,acid-- ,squibb03 ,e4 ,r4 ,squibb ,sons1 ,new ,york4 8,acetylsalicylic ,acid-- ,m]ck03 ,m]ck ,co41 ,new ,york4 8,acetylsalicylic ,acid-- ,millik503 ,john ,t4 ,millik5 ,co41 ,/4 ,l\is4 8,acetylsalicylic ,acid-- ,m4 ,c4 ,w403 ,mall9ckrodt ,*emical ,works1 ,/4 ,l\is4 8,acetylsalicylic ,acid-- ,monsanto03 ,monsanto ,*emical ,works1 ,/4 ,l\is4 8,acetylsalicylic ,acid-- ,p4 ,w4 ,r403 ,p[]s-,weightman-,ros5g>t5 ,company1 ,philadelphia4 ,lee*'s report gives /ill great] weight to ! sugge/ion t has be5 made = "s "t1 viz41 t physicians %\ld describe acetylsalicylic acid "u its sci5tific "n r ?an its propriet>y "n1 ev5 ?\gh1 9 ! op9ion ( ,! ,j\rnal1 ! propriet>y "n1 aspir91 has become common prop]ty s9ce ! expiration ( ! acetylsalicylic acid pat5t4 ,e consid]ation ( public int]e/1 ( patriotism & ( ord9>y common s5se %\ld prompt physicians to specify acetylsalicylic acid 9 writ+ prescriptions4--7,editorial f ,! ,j\rnal ,a4 ,m4 ,a41 ,april #ac1 #aiah47 ,adv]tis+ ,pr9ciples--,lay & ,m$ical ,! ,j\rnal has receiv$ two lett]s1 "o f a physician :o _h writt5 to ! ,new ,york ,tribune prote/+ aga9/ an adv]tisem5t ( 8,aspir9 7,bay]70 t appe>$ 9 ! rotogravure supplem5t ( a ,sunday edition & ! o!r ! ,new ,york ,tribune's answ] to ! prote/4 ,! two lett]s make an editorial 9 !mselves4 ,"h is ! lett] ( ! physician--,dr4 ,edw9 ,h4 ,%ep>d ( ,syracuse1 ,n4 ,y4--:i* 0 address$ to ! editor ( ,! ,j\rnal3 8,:5 a great daily newspap] takes a /& = hone/ adv]tis+ x seems wor?y t ackn[l$gem5t %\ld be made4 ,on ,april #ad ! illu/rat$ ,sunday supplem5t ( ! ,new ,york ,tribune1 toge!r ) _m ( ! o!r pap]s ( ! c\ntry1 publi%$ a duplicate ( ! enclos$ adv]tisem5t ( #8,aspir94' ,y\r own in/ructive editorial on #8,acetylsalicylic ,acid1 or ,:at's 9 a ,"n8' _h appe>$ 9 ! copy ( ,! ,j\rnal ( ! day prec$+4 8,believ+ 9 ! s9c]ity ( ! ,tribune 9 its ef=t = hone/ adv]tis+1 ,i s5t !m a copy ( y\r editorial toge!r ) ! page ( adv]tisem5t1 also call+ att5tion to ! /atem5ts 9 ! adv]tisem5t :i* seem$ que/ionable4 ,among ! que/ionable matt]s 9 ! adv]tisem5t 7 ! /atem5ts1 #8,! "o g5u9e ,aspir91' #8,no o!r is g5u9e1' #8,t :i* is g5u9e possesses qualities ( excell5ce nev] f\nd 9 imitations1' #8,= y\r protection 444 e package & tablet is m>k$ ) ! ,bay] cross1' #8,y\r gu>antee ( purity1' & #8,refuse sub/itutes z !y may prove ineffective & h>mful4' 8,! ,tribune 0 reque/$ to inve/igate into ! /&+ ( ! ,bay] company & its product4 ,a few days lat] ! enclos$ lett] 0 receiv$ f ! pap]'s ,bureau ( ,inve/igations40 ,& "h is ! ,new ,york ,tribune's answ]1 sign$ by ,r4 ,r4 ,ba]1 assi/ant director ( t pap]'s ,bureau ( ,inve/igations3 8,we h y\r lett] ( ,april #ad?1 :i* 0 ackn[l$g$ on ! #bbnd1 9 re ,aspir94 ,= y\r in=mation3 ,our rotogravure supplem5t is pr9t$ a numb] ( days 9 advance ( ! ,sunday pap]4 ,:5 ^! copies :i* h already be5 pr9t$ are us$1 no fur!r ,aspir9 copy w appe>4 ,?is means a loss ( "s f\r pages40 ,h[ _m ( ! num]\s m$ical j\rnals t are /ill c>ry+ ! 8,aspir9 7,bay]70 adv]tis+ w\ld make su* a f9ancial sacrifice = m]e pr9ciple8--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,may #be1 #aiah47 8,aspir90--,a ,common ,"n 8,aspir90 z a tradem>k w no long] exi/ if ! recomm5dation ( ! ,exam9] ( ,int]f]5ces ( ! ,unit$ ,/ates ,pat5t ,(fice is upheld1 z x probably w\ld be1 %\ld ! matt] be tak5 to ! c\rts4 ,! op9ion ( ! ,pat5t ,(fice 0 ! result ( a petition by ! ,unit$ ,drug ,company 9 ! case ( t company aga9/ ! ,bay] ,company1 or1 z x 0 call$ at ! "t ! suit 0 br\ght1 ! ,f>b5fabrik5 ( ,elb]feld ,company4 ,! /& tak5 by ! ,pat5t ,(fice is directly 9 l9e ) t t has be5 held 9 ?is & o!r cases by ,! ,j\rnal1 :i* has = ye>s insi/$ t x 0 aga9/ public policy to p]mit pat5tees to ext5d ! sev5te5-ye> monopoly1 :i* ! pat5t laws grant1 to a p]petual monopoly by ! simple device ( obta9+ a tradem>k = ! "n ( ! ?+ pat5t$4 ,x is a fundam5tal pr9ciple 9 law t 8no "o c h a monopoly 9 ! "n ( any?+40 ,?is1 ( c\rse1 has be5 recogniz$ & admitt$ ev5 by ^? manufactur]s :o h attempt$ to invoke ! tradem>k laws to obta9 an unw>rant$ advantage4 ,! manufactur]s ( aspir9 h held t ! *emical "n 8monoaceticacide/] ( salicylic acid0 0 ! true "n ( ! pat5t$ article1 & 0 ! only "n :i* became public prop]ty :5 ! pat5t "r expir$4 ,! ,pat5t ,(fice po9ts out1 h[ev]1 t = ye>s ! only "n t ! public ev] saw on ! br& ( monoaceticacide/] ( salicylic acid made by ! hold]s ( ! pat5t on ?is product 0 8,aspir940 ,! ,exam9] ( ,int]f]5ces 9 8 decision po9ts out t1 previ\s to #aiae1 ! ,bay] ,company sold no tablets to ! retail-pur*as+ public1 b m>ket$ its product z a p[d]2 fur!r1 t x did sell va/ quantities ( ! p[d] to tablet-mak]s1 :o sold 8,aspir9 ,tablets10 & t ! consum+ public knew ! product only by ! "n 8,aspir940 ,?is "n1 !n1 _h a significance to ! pur*as]1 simil> to t ( ! ^w 8qu990 on a package ( qu99 tablets1 or ! ^w 8calomel0 on a package ( calomel tablets4 ,z ! ,pat5t ,(fice says3 8,9 o!r words1 ! prima facie significance ( ?is ^w #8,aspir9' to su* pur*as]s 0 t ( a "n0--& z a "n x is 8necess>ily incapable ( exclusive use by any "o40 ,! ,pat5t ,(fice's decision also br+s out ! fact t1 until ! own]s ( ! aspir9 pat5t comm5c$ mak+ tablets !mselves1 ! aspir9 tablets on ! m>ket 7 n uni=m1 & t ?is lack ( uni=mity 0 a fraud on ! public :i* ! own]s ( ! aspir9 pat5t %\ld h prev5t$4 ,! conc]n did prev5t x :5 x began to make ! tablets itself1 b ma9ta9$ 9 its cont5tion aga9/ ! ,unit$ ,drug ,company t x 0 unable to control ! matt] previ\sly--a cont5tion to :i* ! ,pat5t ,(fice gives %ort %rift4 ,x is fur!r po9t$ out t ! ,bay] ,company evid5tly recogniz$ ! weakness ( its cont5tion by ! emphasis x plac$ ?r\gh its adv]tis+ on ! 8,bay] ,cross40 ,:5 ! ,bay] ,company began manufactur+ its own aspir9 tablets1 x made a pret5se ( comply+ ) ! lett] ( ! law1 :ile violat+ its _s1 by plac+ on ! label "u ! ^w 8,aspir910 ! /atem5t t 8! monoaceticacide/] ( salicylic acid 9 ^! tablets is ! reliable ,bay] manufacture40 ,says ! ,pat5t ,(fice3 8,) reg>d to ! expression #8monoaceticacide/] ( salicylic acid1' a m]e inspection ( x is suffici5t to apprise any "o ( its inh]5t unsuitability = use z a "n by ! lay pur*as+ public40 ,?is attempt on ! "p ( ! company to 8beat ! devil ar\nd a /ump0 t5d$1 9 ! op9ion ( ! ,pat5t ,(fice decision1 8to %[ t ! respond5t 0 famili> ) ! me?ods ( "s mod]n trad]s to meet ! tr5d ( ! law40 ,&1 discuss+ su* me?ods1 ! ,exam9] ( ,int]f]5ces says3 8,a v popul> "o is = a trad] to seem+ly b5d to ! necessity ( ! situation by plac+ on ! label a notation :i* 9 !ory1 b n 9 practice1 may be us$ by ! public to id5tify ! article aft] ! monopoly has expir$4 ,to ! exam9] ?is practice seems to be m]ely a manife/ation ( t ke5 comm]cial in/9ct :i* endeavors to keep j ahead ( ! law4 ,?is in/9ct is fairly common 9 trad]s1 & is cle>ly disclos$ 9 tradem>k infr+em5t cases40 ,summ$ up1 ! decision is to ! effect t1 z 9 any case prior to #aiae1 ! public _h be5 driv5 to look on ! ^w 8,aspir90 z ! "n ( a ?+1 & z ! ,bay] ,company _h n us$ ! ^w z a 8tradem>k0 )9 ! mean+ ( ! law1 ! ,pat5t ,(fice recomm5ds t ! regi/ration ( 8,aspir90 z a tradem>k be cancel$4 ,if no appeal is tak5 f ?is decision1 or 9 case an appeal is tak51 %\ld ! op9ion be su/a9$1 ! attempt on ! "p ( ! pat5tees ( aspir9 to get a p]petual monopoly on _! product ?r\gh ! tradem>k laws w h be5 def9itely defeat$4--7,editorial f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #aa1 #aiai47 8,aspir9 ,bay]0 & ! ,/]l+ ,products ,company ,a correspond5t1 :o asks t 8 "n be n publi%$1 writes3 8,y\r editorial on #8,aspir9 or ,acetylsalicylic ,acid--,an ,important ,c\rt ,decision' is timely4 ,too (t51 ,i fe>1 physicians =get #8:at's 9 a "n4' ,i h be5 told t ! ,/]l+ ,products ,co41 ! pres5t own]s ( ! ,aspir9-,bay] rights1 are manufactur]s ( o!r #8pat5t m$ic9es4' ,are !y int]e/$ 9 ! ,w9?rop ,*emical ,company1 :i* firm seems to be us+ ! mu* vaunt$ #8,bay] ,cross' on ! labels ( ! products =m]ly import$ f ,g]many by #8,! ,bay] ,company'8 ,if y answ] ?is 9 ,! ,j\rnal1 k9dly omit my "n40 ,! rec5t hi/ory ( ,bay] ,co41 is some:at z foll[s3 ,%ortly aft] ! ,unit$ ,/ates ent]$ ! w>1 ! ,ali5 ,prop]ty ,cu/odian took ov] ! prop]ty ( ,bay] ,co4 7,inc47 & its subsidi>y1 ! ,syn!tic ,pat5ts ,co4 ,9 8 report to congress ! ,cu/odian said3 8,! /ock ( ,bay] ,co4 7,inc47 & ( ,syn!tic ,pat5ts ,co4 0 sold by me at public auction1 ! successful bidd] be+ ! ,/]l+ ,products ,co41 a ,we/ ,virg9ia corporation deal+ 9 propriet>y m$ic9es4 ,?is company _h previ\sly agre$ to dispose ( ! dye plant & pat5ts1 9 case x secur$ ! prop]ty1 to ,grasselli ,*emical ,co41 "o ( ! l>ge/ mak]s ( heavy *emicals 9 ! c\ntry4 ,! price paid 0 #e1caj1jjj1 plus back taxes & o!r obligations ( _m hundr$ ?\s&s m40 ,aft] ! ,/]l+ ,products ,company _h acquir$ ! ph>maceutical end ( ! bus9ess1 ! ,w9?rop ,*emical ,co4 0 incorporat$ 9 ! /ate ( ,new ,york4 ,?is conc]n seem+ly secur$ control ( all ! ,bay] ph>maceutical specialties except 8,aspir940 ,! ,bay] ,co41 x 0 ann\nc$1 _h be5 m]g$ ) ! ,/]l+ ,products ,co41 & 8,aspir9-,bay]0 add$ to ! latt] firm's li/ ( 8pat5t m$ic9es03 ,casc>ets1 ,d&]9e1 ,pape's ,diapeps91 ,cali=nia ,syrup ( ,figs1 ,neuralg9e & ,dodson's ,liv]tone4 ,! bus9ess is app>5tly a pay+ "o f9ancially z witness ! foll[+ exc]pt f a rec5t ann\ncem5t 9 a drug j\rnal3 8,/ockhold]s ( ! ,/]l+ ,products ,co41 ,inc41 ( ,:eel+1 manufactur]s ( ,neuralg9e1 ,casc>ets1 ,bay]'s ,aspir91 & o!r well kn[n products1 & ! l>ge/ propriet>y m$ic9e organization 9 ! _w1 at _! annual meet+ receiv$ a report ( ,manag] ,w4 ,e4 ,weiss1 :i* %[$ t ! company did a #aj1jjj1jjj bus9ess 9 #aibj4 ,! total pr(its 7 #b1ajj1jjj1 :ile a total ( #a1jhj1jjj 0 paid out 9 divid5ds40 ,j :at relation%ip exi/s betwe5 ! ,w9?rop ,*emical ,co41 & ! ,/]l+ ,products ,co41 we d n "k4 ,z our correspond5t po9ts out1 ! 8,bay] ,cross0 is us$ on ! label ( ! ,w9?rop products4 ,! adv]tis+ campaign ( 8,aspir91 ,bay]0 s9ce x ent]$ ! 8pat5t m$ic9e0 field has be5 typical ( t field4 ,by half tru?s & inf]5tial falsehoods ! public has be5 l$ to believe t ! only g5u9e aspir9 on ! m>ket is t put out "u ! ,bay] "n4 ,! facts are1 ( c\rse1 t ! aspir9 ( any reputable firm is j z good z ! aspir9 put out by ! mak]s ( ,liv]tone1 ,d&]9e & ,casc>ets4 ,!re is "o po9t1 h[ev]1 t is ( vital importance to ! m$ical pr(ession2 ,! decision rec5tly r5d]$ 9 ! ,unit$ ,/ates ,di/rict ,c\rt ( ,s\!rn ,new ,york makes x obligatory = druggi/s1 :5 fill+ a physician's prescription call+ = 8aspir910 to disp5se ! ,bay] product4 ,:5 ! public buys aspir9 on its own responsibility--)\t specify+ any p>ticul> br&--! druggi/ may give ! pur*as] any make ( acetylsalicylic acid he sees fit4 ,to repeat :at 0 said 9 ,! ,j\rnal's comm5t on ?is decision3 8,unless a physician wi%es to cat] to ! conc]n own+ ! ,bay] rights & to aid 9 p]petuat+ :at 0 a monopoly = sev5te5 ye>s1 he %\ld be c>eful to prescribe ! drug "u ! t]m #8acetylsalicylic acid1' ,! c\rt n[ places ! responsibility directly on ! m$ical pr(ession4 ,avoid #8aspir9'--write #8acetylsalicylic acid4'--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,june #aa1 #aiba47 ,,! ,,alli$ ,,m$ical ,,associations ,,( ,,am]ica ,ano!r ,rocket 9 ! ,pyrote*nics ( ,quasim$ical ,organizations ,x 0 once said1 9 ! days :5 diploma mills fl\ri%$1 t x seem$ easi] to />t a 8univ]sity0 ?an x 0 to op5 a grog %op4 ,a /udy ( quasim$ical organizations conv9ces "o t x is easi] to f\nd a 8m$ical society0 ?an x is to e/abli% a peanut /&4 ,mo/ reputable practition]s ( m$ic9e :o c>e to affiliate !mselves ) m$ical organizations are memb]s ( ! ,am]ican ,m$ical ,association1 its compon5t societies1 or simil> sci5tific bodies4 ,x is n surpris+ !n1 t ^? :o live & move 9 ! twilight zone ( pr(essionalism1 f vision>ies rid+ biz>re m$ical hobbies to ^? :o h special int]e/s to exploit1 %\ld create & make use ( hybrid m$ical organizations4 ,su* organizations multiply z rapidly z rabbits4 ,!y fl\ri% = a :ile1 obta9 m or less newspap] & o!r publicity--usually m1 because ( ! s5sational me?ods ( ^? controll+ !m--!n1 hav+ s]v$ ! purpose ( ^? :o br\ght !m into be+1 !y lapse into innocu\s desuetude4 ,! (ficial acc\*em5t ( ! ,alli$ ,m$ical ,associations ( ,am]ica occurr$1 accord+ to t organization's report1 ,may #ah1 #aiah4 ,on ! (ficial /ation]y ( ! ,alli$ ,m$ical ,associations ( ,am]ica 9 use 9 ,may1 #aiai1 we f9d ! names ( ! 8,(fic]s10 8,c5sors10 etc4 ,^! con/itute1 presumably1 ! m prom95t memb]s ( ?is organization4 ,we give briefly1 "s data reg>d+ "s ( ^! s t a rational p]spective may be obta9$3 ,l4 ,m4 ,ott(y1 ,m4,d41 ,/4 ,l\is1 ,mo4--,dr4 ,ott(y seems to h be5 ! *ief organiz]1 if n1 inde$1 ! f\nd]4 ,he has be5 its 8,secret>y-,treasur]0 s9ce its inception2 he is also 8editor0 ( its j\rnal4 ,ott(y1 accord+ to our records1 0 born 9 #ahfe at ,budape/1 ,hung>y1 & 0 graduat$ 9 #ahhh by ! ,homeopa?ic ,m$ical ,college ( ,miss\ri4 ,9 ,polk's ,m$ical ,directories = #aiad & #aiag1 ,ott(y has ^? ext5d$ notices :i* any physician c obta9 :o c>es to pay = !m4 ,accord+ to ^! notices1 ,ott(y is1 or has be51 affiliat$ ) ! foll[+ 8societies03 ,presid5t ( ! ,int]national ,canc] ,rese>* ,society4 ,ex-,presid5t ( ! ,/4 ,l\is ,society ( ,m$ical ,rese>*4 ,second ,vice ,presid5t ( ! ,miss\ri ,in/itute ( ,homeopa?y4 ,g5]al ,secret>y ( ! ,am]ican ,association ( ,progressive ,m$ic9e4 ,*airman ( ! ,bo>d ( ,c5sors ( ! ,miss\ri ,in/itute ( ,homeopa?y4 ,memb] ( ! ,am]ican ,in/itute ( ,homeopa?y4 ,memb] ( ! ,s\!rn ,homeopa?ic ,association4 ,memb] ( ! ,am]ican ,association ( ,orificial ,surgeons4 ,memb] ( ! ,s\!rn ,homeopa?ic ,m$ical ,society4 ,memb] ( ! ,kansas ,city ,society ( ,m$ical ,rese>*4 ,honor>y memb] ( ! ,*icago ,society ( ,m$ical ,rese>*4 ,9 ,decemb]1 #aiaa1 num]\s newspap] clipp+s %[ t ,dr4 ,ott(y 0 obta9+ mu* publicity relative to 8 antivacc9ation activities4 ,at t "t ! pap]s report$ t ,ott(y 0 su+ ! ,/4 ,l\is ,bo>d ( ,education = #be1jjj damages1 because ! bo>d w\ld n admit to ! s*ools ( ! city a *ild he _h 8int]nally0 vacc9at$4 ,9 ,novemb]1 #aiac1 ! ,/4 ,l\is ,republic report$ t ,ott(y _h claim$ to h discov]$ a s]um = ! cure ( canc]1 & quot$ ,ott(y z claim+ 8a record ( #gb p] c5t4 ( cures0 9 8select$ cases40 ,9 ,febru>y1 #aiad1 ! newspap]s report$ t ,ott(y 0 mak+ a trip ea/ 8on ! trail ( radium = use 9 8 practice 9 ! cure ( canc]0 & quot$ him z /at+1 8,i h le>n$ on good au?ority t !re is radium 9 ,miss\ri1 & j :]e ,i refuse to divulge at ?is "t40 ,9 ,janu>y1 #aiae1 ! ,/4 ,l\is ,republic report$ t ,ott(y1 at a meet+ ( ! 8,/4 ,l\is ,society ( ,m$ical ,rese>*10 _h ann\nc$ t he _h p]fect$ a s]um treatm5t = canc]1 :i* 8is cur+ pati5ts :o h be5 pron\nc$ incurable by s-call$ #8canc] exp]ts4'0 ,9 ,janu>y1 #aiaf1 ! ,/4 ,l\is ,/> report$ t ,ott(y _h s\ght an injunction aga9/ ! ,bo>d ( ,education ( ,/4 ,l\is to re/ra9 x f us+ its funds = 8! ma9t5ance ( a ,bo>d ( ,hygi5e40 ,9 ,july1 #aiaf1 ,/4 ,l\is pap]s record$ t ,ott(y1 :o 0 !n runn+ = coron]1 _h be5 cit$ to appe> be=e ! prosecut+ attorney to expla9 a *>ge ( pass+ out1 at a political meet+1 a c>d alleg$ to h borne an indec5t draw+ ( ,presid5t ,wilson4 ,! prosecut+ attorney 0 said to h in/ruct$ ,ott(y to br+ ! plates f :i* ! c>ds 7 pr9t$ to 8 (fice4 ,two days lat] ! pap]s /at$ t ,ott(y _h s5t ! c>ds & plates by mess5g] to ! prosecut+ attorney's (fice4 ,n4 ,la ,doit ,johnson1 ,m4,d41 ,*icago4--,dr4 ,johnson's "n appe>s z ! 8,fir/ ,vice-,presid5t0 ( ! ,alli$ ,m$ical ,associations ( ,am]ica4 ,a few ye>s ago1 ,dr4 ,johnson's "n also appe>$ z ! 8,dean ( ! ,faculty0 ( ! 8,am]ican ,po/ ,graduate ,s*ool40 ,?is 8s*ool0 0 a mail-ord] conc]n :i*1 accord+ to ! 8,annual ,ann\ncem5t10 w\ld grant diplomas & conf] degrees z foll[s3 8,ma/] ( ,surg]y10 8,ba*elor ( ,m$ic9e10 8,ba*elor ( ,sci5ce10 8,ma/] ( ,electro-,!rapy10 8,doctor ( ,o/eopa?y10 8,doctor ( ,psy*ology10 8,ma/] ( ,massage10 etc4 ,h4 ,m4 ,goehr+1 ,d4,o41 ,m4,d41 ,pittsburgh1 ,pa4--,! 8,second ,vice-,presid5t10 accord+ to ! lett]heads ( ! 8,association0 c>ries ! lett]s ,d4,o41 ,m4,d41 aft] 8 "n4 ,s f> z our records %[1 & !y are mo/ complete & bas$ on (ficial data1 ,h4 ,m4 ,goehr+ is an o/eopa?1 b n a doctor ( m$ic9e4 ,a4 ,e4 ,erl+1 ,m4,d41 ,milwaukee1 ,wis4--,a4 ,e4 ,erl+1 accord+ to ! /ation]y1 is 8,*airman0 ( 8,c5sors40 ,our records fail to %[ t ,erl+ ev] graduat$ 9 m$ic9e4 ,! ,heal? ,dep>tm5t ( ,milwaukee1 h[ev]1 says t ,erl+1 :5 int]view$1 claim$ to h 8a diploma f ! ,g]man ,m$ical ,college ( ,*icago1 b refus$ to %[ or pres5t ! same40 ,! ,am]ican ,m$ical ,directory has ?is item3 ,g]man ,m$ical ,college1 ,*icago4 ,*>t]$ ,dec4 #bh1 #ahia1 by ,johann ,malok4 ,fraudul5t4 ,ext9ct4 ,a few ye>s ago ,erl+ 0 9 ,la ,crosse1 ,wis42 & 9 #aijh a circul> lett] be>+ 8 "n & picture 0 s5t out f :i* ! foll[+ extracts are tak54 ,capitalization z 9 ! orig9al3 8,de> ,fri5d3--,p]mit me to call y\r att5tion to ! fact t ,dr4 ,a4 ,e4 ,erl+1 ! em95t speciali/1 aft] _m ye>s ( travel1 practice & m$ical rese>*1 has giv5 up 8 ext5sive road practice & sev]$ 8 connection ) ! sev]al m$ical in/itutes :i* h h]et(ore occupi$ consid]able ( 8 att5tion 444 ,dr4 ,erl+'s success 9 ! treatm5t ( all ,,*ronic ,,diseases is truly rem>kable4 ,,n]v\sness1 all ,,blood ,,diseases1 ,,rheumatism1 ,,diseases ,,peculi> ,,to ,,wom51 ,,cat>rh1 ,,deafness1 ,,*ronic ,,con/ipation 444 ,,app5dicitis 444 ,,piles1 ,,/oma* ,,tr\bles1 ,,p>tial ,,p>alysis1 etc41 give way z if by magic "u 8 skillful me?od ( treatm5t 444 ,und]/& please1 t ,dr4 ,erl+ ,,does ,,n ,,accept ,a ,,case ,,= ,,treatm5t unless he c ,,promise ,a ,,spe$y ,,& ,,positively ,,p]man5t ,,cure40 ,! ,j\rnal also has 9 its files adv]tisem5ts 7v9tage ( #aiae71 f "s ,wiscons9 c\ntry newspap]s1 :i* notify ! afflict$ t 8,drs4 ,erl+ & ,k>ass1 ! exp]t ,g]man ,speciali/s10 c\ld be se5 9 _! (fices 9 ! 8,s*legel ,hotel10 ! 8,s*litz ,hotel10 etc41 z ! case might be4 ,:e!r "o ( ^! 8,g]man ,speciali/s0 0 ,dr4 ,arnold ,e4 ,erl+1 ,! ,j\rnal does n "k4 ,(ficial m$ical records fail to %[1 at lea/1 t !re is any o!r ,erl+ 9 ! /ate ( ,wiscons94 ,w4 ,w4 ,fritz1 ,m4,d41 ,philadelphia4--,ano!r ( ! 8,c5sors40 ,?is presumably is ,w4 ,wallace ,fritz1 ,m4,d41 ,d4,d4,s41 ,n4,d41 ,d4,o41 ,d4,c41 :o 0 ! 8,dean0 ( ! 8,am]ican ,college ( ,neuropa?y10 & 8,pr(essor ( ,neuropa?y0 at ! same in/itution4 ,accord+ to newspap] reports publi%$ :5 ! 8dean0 ( ! ,am]ican ,college ( ,neuropa?y 0 call$ into c\rt to te/ify reg>d+ ! 8s*ool10 ,fritz admitt$ t :5 he became dean ( ?is 8college10 ! 8college0 _h ?ree /ud5ts & ?irty 8,faculty ,memb]s06 ,fritz1 x %\ld be m5tion$ 9 pass+1 is a memb] ( ! ,philadelphia ,c\nty ,m$ical ,society & by virtue ( ?is memb]%ip he has qualifi$ z a ,fell[ ( ! ,am]ican ,m$ical ,association6 ,rec5tly ,fritz's "n appe>$ 9 connection ) ! =mation ( a new organization1 f\nd$1 x appe>s1 = ! laudable purpose ( fight+ ! 8,m$ical ,tru/40 ,fritz1 accord+ to ! newspap] reports1 is treasur] ( ?is new organization1 :i* has adopt$ ! inspir+ title1 8,con/itutional ,lib]ty ,league ( ,am]ica0 & seems to be a lat] edition ( ! mu%room 8,national ,league = ,m$ical ,fre$om40 ,quot+ f ! newspap] report3 8,dr4 ,w4 ,wallace ,fritz1 a memb] ( ! ,am]ican ,m$ical ,association1 creat$ a pr(\nd impression :5 he said t all heal? laws 7 writt5 by ag5ts (1 or memb]s (1 ! ,am]ican ,m$ical ,association1 & t ?is organization 0 at once ! mo/ p[]ful & ! mo/ baneful ( all ! ,am]ican ,tru/s4 ,dr4 ,fritz !n w5t on to say3 #8,mo/ ( ! drugs adm9i/]$ are wor?less4 ,mo/ ( ! doctors :o prescribe !m are incompet5t1 b bo? ! injuri\s drug & ! ignorant prescrib] are protect$1 9 & out ( c\rt1 by ! ,am]ican ,m$ical ,association1 :i* tru/ is n[ rais+ a va/ fund ) :i* to drive all drugless heal]s out ( ! pr(ession4 ,m$ic9e is ! cam\flage us$ to conceal ! mo/ al]t1 ! mo/ rapaci\s & ! lea/ patriotic ( all ! tru/s milk+ ! ,am]ican p4 ,! tyranny ( ! ,m$ical ,tru/ is unbelievable4 ,x is also un-,am]ican4'0 ,! ,philadelphia ,sunday ,transcript ( ,may #d1 #aiai1 _h a five column article "u ! "n ( ,w4 ,wallace ,fritz4 ,x is a mo/ vitup]ative affair1 & reeks ) fire & brim/one4 ,x is direct$ *iefly aga9/ ! ,am]ican ,m$ical ,association1 & physicians are dubb$ 8,prescription ,writ+ ,drug ,p$dl]s ,:o ,prosp] ,?r\gh ,monopoli/ic ,laws ,r ?an by ! ,practice ( an ,exact ,sci5ce40 ,9 ! c\rse ( ?is diatribe we read3 8,! memb]s ( ! ,am]ican ,m$ical ,association are manife/+ an unw>rant$ int]e/ 9 ! de> p1 :o1 9 _! assumption1 ne$ qu99 & m]curial gu>dian2 :o "u ?is class legislation conf9es u to ?is monopoly ( ! big & little pill1 is try+ by hook & crook to %ut out ! natural & rational me?ods ( cure :i* are driv+ ! drug monopoly f ! face ( ! e>?4 ,diagnosis & consultation consi/ 9 f\r or five m$ical doctors1 ^: faces d5ote dea?1 sitt+ ar\nd a sick man & guess+ :at ails him4 ,aft] t has be5 p]=m$ !y guess at :at w cure him1 & t is g5]ally a sure sign ! und]tak] w foll[40 ,c4 ,o4 ,l9d]1 ,m4,d41 ,spokane1 ,wa%4--,?is g5tleman 7ano!r 8,c5sor071 seems to be an o/eopa?1 :o "s ye>s ago 0 8,assi/ant ,secret>y0 ( ! 8,wa%+ton's ,physicians' ,association10 f\nd$ app>5tly by rebels )9 ! o/eopa?ic ranks :o d5\nc$ ! ,wa%+ton ,o/eopa?ic ,association z a 8pr(essional tru/06 ,l9d] app>5tly claims graduation 9 #aije f ! 8,?ompsonian ,m$ical ,college0 ( ,all5t[n1 ,pa4 ,! foll[+ item f ! ,am]ican ,m$ical ,directory reg>d+ ?is s*ool is ( int]e/3 8,?ompsonian ,m$ical ,college1 ,all5t[n4 ,organiz$ 9 #aijd4 ,fraudul5t4 ,no evid5ce to %[ classes 7 ev] held40 ,a4 ,h4 ,fl[]1 ,m4,d41 ,bo/on4--,/ill ano!r 8,c5sor40 ,fl[]1 accord+ to ! notice t appe>s 9 ,polk's ,directory = #aiag1 claims graduation 9 #ahhh f ! 8,am]ican ,heal? ,college0 ( ,c9c9nati1 & 9 #ahid f ! 8,am]ican ,heal? ,univ]sity0 ( ,*icago4 ,quot+ aga9 f ! ,am]ican ,m$ical ,directory1 "h is :at we f9d reg>d+ ! =m] 8college03 8,am]ican ,heal? ,college1 ,c9c9nati4 ,organiz$ 9 #ahgd & re-organiz$ 9 #ahgf4 ,conduct$ by a ,dr4 ,campbell :o orig9at$ & copyright$ ! s-call$ #8,vitapa?ic ,sy/em1' ,fraudul5t4 ,ext9ct ab\t #ahhh40 ,we h no record ( an 8,am]ican ,heal? ,univ]sity0 ( ,*icago1 al?\gh !re 0 an 8,ill9ois ,heal? ,univ]sity0 ( ,*icago1 "o ( ! num]\s diploma-mill sw9dles op]at$ by ,arm/rong4 ,x 0 decl>$ fraudul5t by ! f$]al au?orities & its *>t] 0 revok$ 9 #ahig4 ,fl[]1 accord+ to ! notice 9 ,polk's ,directory1 is3 ,ex-,presid5t ,ma9e ,eclectic ,society4 ,ex-,presid5t ,new ,engl& ,eclectic ,m$ical ,association4 ,memb] ,national ,eclectic ,m$ical ,association4 ,memb] ,am]ican ,progressive ,m$ical ,society4 ,memb] ,massa*usetts ,eclectic ,m$ical ,society4 ,z4 ,l4 ,baldw91 ,m4,d41 ,kalamazoo1 ,mi*4--,possibly ! data j giv5 conc]n+ "s ( ^? ^: names appe>$ on ! organization's /ation]y are m ?an suffici5t = ! av]age physician to get a p]spective ( ! ,alli$ ,m$ical ,associations ( ,am]ica4 ,/ill1 x is wor? m5tion+ t 9 a lett] rec5tly s5t out by ,ignatz ,may]1 ext5d+ an invitation to ! annual conv5tion ( ! ,alli$ ,m$ical ,associations ( ,am]ica1 ,may] took ! opportunity ( incorporat+ 9 8 lett] a lett] :i* "o ( ! memb]s ( ! 8association0 _h be5 s5d+ out1 urg+ individuals to jo94 ,! memb] 9 "q 0 ,dr4 ,z4 ,l4 ,baldw9 ( ,kalamazoo1 ,mi*4 ,dr4 ,baldw91 z "s ( our read]s may rememb]1 is ! g5tleman :o1 a few ye>s ago1 0 exploit+ an 8,intrav5\s ,treatm5t0 = ! cure ( tub]culosis4 ,accord+ to ! claims made at t "t3 8444 = ! fir/ "t 9 ! hi/ory ( m$ic9e1 we h a successful treatm5t = tub]culosis4 8444 we are able to kill ! g]ms ( ! disease 9 ! body1 ?or\ghly ridd+ x ( all tub]cul> infection1 de/roy+ ! g]m & its poisons likewise40 ,?is 0 a few ye>s ago4 ,:e!r ,dr4 ,baldw9 is /ill specializ+ 9 consumption we d n "k2 app>5tly n1 z we notice t at ! fir/ meet+ ( ! ,alli$ ,m$ical ,associations1 ,baldw9's "n 0 on ! program = ! 8,cure ( ,goit] by ,adju/m5t ( ,l5ses40 ,george ,/>r ,:ite1 ,m4,d41 ,f4,s4,sc41 ,lond41 ,los ,angeles1 ,calif4--,a lett] receiv$ by a physician a few days be=e ! rec5t conv5tion ( ! ,alli$ ,m$ical ,associations1 held out z an inducem5t to be pres5t ! fact t 8,geo4 ,s4 ,:ite w %[ y h[ to diagnose disease by means ( dif4 color$ lights & ! reaction ( ! body to ! magnetic m]idian40 ,dr4 ,george ,/>r ,:ite 0 ! 8,second ,vice-,presid5t0 ( ! ,alli$ ,m$ical ,associations 9 #aiah4 ,:ite1 accord+ to our records1 0 graduat$ 9 #aijh :5 he 0 =ty-two ye>s old1 by ! ,new ,york ,homeopa?ic ,m$ical ,college & ,hospital4 ,he 0 lic5s$ 9 ,new ,york 9 #aijh1 9 ,cali=nia1 ,connecticut & ,nevada 9 #aiac1 & 9 ,mi*igan 9 #aiaf4 ,he seems to h be5 "o ( ! propon5ts ( 8spondylo!rapy10 8zone!rapy10 etc41 & 9 #aiae x 0 ann\nc$ t he w\ld give "o week c\rses 9 8,spondylo!rapy0 9 ,*icago1 ,kansas ,city & ,d5v]1 respectively4 ,9 8 adv]tisem5t he emphasiz$ t he 0 a ,fell[ ( ! ,am]ican ,m$ical ,association1 :i*1 :ile true at ! "t1 is no long] true1 z on ,feb4 #d1 #aiaf1 he 0 expell$ f memb]%ip 9 ! ,los ,angeles ,c\nty ,m$ical ,association4 ,9 ,may1 #aiae1 ,:ite 0 arre/$ 9 ,*icago & f9$ #ajj & co/s = practic+ m$ic9e )\t a lic5se4 ,dr4 ,:ite's specialty seems to be :at is pond]\sly kn[n z 8,bio-,dynamo-,*romatic ,diagnosis40 ,?is has be5 describ$ by "o ( its en?usia/ic adh]5ts z 8,diagnosis by ,sympa!tic ,vagal-,reflex40 ,to obta9 ! 8,sympa!tic ,vagal-,reflex0 x seems ! pati5t mu/ face ea/ or we/ & h 8 b>e abdom5 p]cuss$ until a dull area is locat$4 ,! pati5t is !n fac$ nor? or s\? & aga9 p]cuss$4 ,!n1 x seems1 diff]5t color$ lights are ?r[n on ! pati5t1 ! location ( ! areas ( dullness be+ det]m9$ mean:ile4 ,a comb9ation ( ruby & blue lights 8w cause a reflex 9 cases ( gonorrhea10 a 8gre5 light w cause a reflex 9 cases ( liv] or gallbladd] tr\ble10 :ile ! color = c>c9oma is orange r$6 ,dur+ ! height ( ! influ5za epidemic la/ w9t]1 ,:ite seems to h put on ! m>ket 8,val5s ,ess5tial ,oil ,tablets0 :i* 7 = 8,gripp+ ! ,flu out ( ,influ5za10 & 7 also said greatly to b5efit or cure incipi5t tub]culosis1 hay-fev]1 a/hma1 & 8cat>40 ,! lett]s 8,f4,s4,sc41 ,lond40 aft] ,dr4 ,:ite's "n look well1 s\nd well1 & h an air ( erudition & my/]y t is well wor? :at !y co/4 ,!y mean 8,fell[ ( ! ,incorporat$ ,society ( ,sci5ce1 ,lett]s & ,arts ( ,london1 ,ltd40 ,! 8,fell[%ip0 co/s "o gu9ea4 ,n a few 8pat5t m$ic9e0 exploit]s 9 ! ,unit$ ,/ates c>ry ^! my/ic lett]s aft] _! names4 ,! society 9 "q 0 a s]iocomic conc]n t 0 expos$ by ,london ,tru? "s ye>s ago & 0 also dealt ) 9 ,! ,j\rnal ( ,may #bi1 #aiji1 9 connection ) ! 8,aicsol ,consumption ,cure0 expos4 ,s mu* = ! ,alli$ ,m$ical ,associations ( ,am]ica4 ,at _! rec5t meet+ 9 ,new ,york ,city !y got mu* newspap] publicity because ( _! action on ! prohibition "q4 ,accord+ to ! newspap] reports1 ! organization adopt$ a resolution decl>+ t 8prop]ly brew$ lag] be] is absolutely ess5tial 9 ! treatm5t ( c]ta9 cases40 ,!y 7 fur!r report$ z endors+ ! manufacture ( light w9es & ( be] conta9+ n to exce$ #b4ge p] c5t4 alcohol4 ,z a piece ( publicity "w ?is resolution 0 all t its sponsors c\ld expect4 sc,! ,j\rnal_/sc (fice 0 flood$ ) telegrams & lett]s f physicians1 temp]ance work]s1 congressm51 *ur* organizations1 & o!rs1 ask+1 9 effect1 ,:at is ! ,alli$ ,m$ical ,associations ( ,am]ica8 ,?is is our apology = giv+ ! am\nt ( space necess>y to a prop] und]/&+ ( ?is organization4 ,today ! rocket ( ! ,alli$ ,m$ical ,associations ( ,am]ica is blaz+ a m or less erratic c\rse across ! sky ( publicity4 ,! /ick w be d[n anon6 ,any resolution or expression ( op9ion by ?is organization1 or o!rs ( its type1 :5 deal+ ) ! broad] problems ( public heal?1 is :olly )\t sci5tific significance1 :e!r su* resolutions are good1 bad or indiff]5t4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,july #e1 #aiai47 8,,ars5icals0 ,! ,septemb] issue ( ! ,ar*ives ( ,d]matology & ,syphilology pres5ts a numb] ( significant features reg>d+ ! use ( arsph5am9 & relat$ comp\nds t are at pres5t be+ widely employ$ 9 ! treatm5t ( syphilis4 ,to "o :o /udies ^! /atem5ts ( laboratory & cl9ical inve/igators 9 ! special field involv$ !re mu/ come ! conviction t _m !rapeutic p]plexities /ill rema9 at ! end ( ne>ly a decade ( trial = ! types ( comp\nds :i* ,ehrli* introduc$4 ,x is well = ! practition] to realize ?is1 especially :5 exp]t work]s /ill make an appeal = cons]vative int]pretations4 ,/okes =cefully summ>iz$ ! situation :5 he /at$ at ! ,new ,orleans session ( ! ,am]ican ,m$ical ,association3 ,too %ort a "t has elaps$ s9ce ! discov]y ( ^! drugs1 & too little is z yet kn[n ab\t ! ultimate problems ( ! pa?ology1 immunology & p>asitology ( syphilis1 to ju/ify ! ann\nc+ ( new infallibilities4 ,! necropsy pa?ologi/ ( ! next fifty ye>s may well1 l ,w>?91 upset our mo/ plausible g5]alizations ( today4 ,season$ tradition & cons]vatism are /ill ! wise/ guides 9 our int]pretation ( cl9ical cure4 ,arsph5am9 has made x app>5tly possible & ev5 probable1 b only to ! inexp]i5c$ has cure be5 made absolute & inevitable4 ,x is recogniz$ t ! exact composition ( arsph5am9 9 its available =m is n fully det]m9$4 ,z has be5 emphasiz$ aga91 ! quantitative det]m9ation ( ars5ic alone 9 arsph5am9 is insuffici5t to e/imate its purity2 9 fact1 ! int]/ate sale ( arsph5am9 is controll$ by toxicity te/s on gu9ea-pigs made by ! ,hygi5ic ,laboratory ( ! ,unit$ ,/ates ,public ,heal? ,s]vice4 ,consequ5tly1 practical m$ic9e mu/ be on its gu>d to employ a product :i* is c>efully controll$ by su* toxicity te/s z well z by o!r crit]ia4 ,x w n d to *>ge unt[>d results (fh& solely to idiosyncrasy ( ! pati5t1 faulty adm9i/ration or o!r errors 9 te*nic4 ,! drug itself /ill has inh]5t dang]s4 ,x %\ld be borne 9 m9d also t neo-arsph5am9 behaves diff]5tly 9 ! animal organism f arsph5am91 & %\ld n be reg>d$ simply z arsph5am9 9 a conv5i5t =m = adm9i/ration4 ,x is gratify+ to le>n f a gov]nm5t exp]t t aft] ! long /ruggle to produce satisfactory products1 arsph5am9 prep>ations made 9 ! ,unit$ ,/ates are g5]ally less toxic ?an ^? ( =eign manufacture4 ,neo-arsph5am9 prep>ations made 9 ! ,unit$ ,/ates comp>e favorably1 & 9 c]ta9 in/ances are decid$ly less toxic ?an mo/ ( ! =eign products4 ,timely pres5tations ( ! faults & dang]s z well z ! undisput$ advantages ( curr5t !rapy 9 ! managem5t ( syphilis %\ld be welcom$4--7,editorial f ,! ,j\rnal ,a4 ,m4 ,a41 ,oct4 #i1 #aibj47 ,ph>macology ( ,ars5icals ,! ,public ,heal? ,s]vice "s "t ago#bfb w>n$ aga9/ ! use 9 syphilis ( new ars5icals :i* are n relat$ to arsph5am92 x 0 /at$ t a numb] ( su* 7 be+ sold ) unw>rant$ claims z to _! value4 ,at lea/ ?ree su* ars5icals h 9 rec5t ye>s be5 ! subject ( "s exploitation = use 9 ?is disease3 sodium cacodylate1 ! sodium salt ( me?yl ars5ic acid 78,arrh5al07 & ! sodium salt ( e?yl ars5ic acid 78,mon-,arsone074#bfc ,z reg>ds ! fir/ two1 ,ca/elli %[$ sev]al ye>s ago t nei!r has any action on exp]im5tal trypanosomiasis & spiro*ete infections2 c>eful cl9ical obs]vations 9 ?is c\ntry h confirm$ ! inefficacy ( sodium cacodylate 9 human syphilis4#bfd ,voegtl9 & ,smi?#bfe ( ! ,hygi5ic ,laboratory h n[ %[n 9 animal exp]im5ts t e?yl ars5ic acid 78,mon-,arsone07 is devoid ( any practical trypanocidal action4 ,?us ! 8!rapeutic ratio0 7! ratio ( ! m9imal effective dose to ! le?al dose7 0 ab\t #a1 t is1 x 0 effective !rapeutically only 9 approximately fatal doses1 ! !rapeutic ratio = arsph5am9 9 simil> conditions 0 #ag1 & t ( neo-arsph5am91 #bh4 ,9 fact1 ! conditions ) e?yl ars5ic acid 7 no m favorable ?an 7 ^? ) ars5\s acid 7! active con/itu5t ( solution ( potassium ars5ite71 al?\gh x 0 f> less poison\s4 ,! validity ( su* exp]im5ts 9 det]m9+ ! probable value ( drugs 9 human syphilis _c be que/ion$3#bff x 0 by su* exp]im5ts t ,ehrli* & 8 co-work]s f\nd two or ?ree ( six hundr$ & six ars5ic prep>ations /udi$ to be ( value1 & ( ! next ?ree hundr$ or m /udi$ only "o 7neo-arsph5am97 wor?y ( trial 9 human m$ic9e4 ,! "t has pass$ :5 a high ars5ic cont5t ( a comp\nd & a l[ toxicity1 & a numb] ( cases ( app>5t cl9ical improvem5t1 c be assum$ to indicate t a drug has any real value 9 ! treatm5t ( syphilis4 ,_m organic comp\nds ( ars5ic z well z o!r drugs may cause tempor>y or app>5t improvem5t 9 syphilis1 b to date only ^? relat$ to arsph5am9 h prov$ ( real value & comp>atively safe4 ,o!rs :i* _h "s real value prov$ to h dang]\s side effects2 read]s w recall ! hi/ory ( arsanilic acid 78,atoxyl0 or 8,soam907 & its acetyl d]ivative 78,arsacet9074--7,editorial f ,! ,j\rnal ,a4 ,m4 ,a41 ,feb4 #bf1 #aiba47 #bfb ,w>n+ ,aga9/ ,untri$ ,m$icam5ts1 ,j4 ,a4 ,m4 ,a4 #gd3afed 7,june #ab7 #aibj4 #bfc ,wright1 ,b4 ,l42 ,k5nell1 ,l4 ,a41 & ,hussey1 ,l4 ,m43 ,m$4 ,rec4 #ig3fjg 7,april #aj7 #aibj4 #bfd ,ni*ols1 ,h4 ,j43 ,salv>san & ,sodium ,cacodylate1 ,j4 ,a4 ,m4 ,a4 #ef3dib 7,feb4 #ah7 #aiaa4 #bfe ,voegtl91 ,c>l1 & ,smi?1 ,h4 ,w43 ,j4 ,ph>macol4 ,exp]4 ,!rap4 #af3ddi1 #aiba4 #bff ,comp>e ,s*amb]g1 ,j4 ,f42 ,kolm]1 ,j4 ,a41 & ,raiziss1 ,g4 ,w43 ,am4 ,j4 ,m4 ,sc4 #aej3be 7,july7 #aibj4 ,salv>san3 ,abrogate ! ,pat5t ,! ,j\rnal has already comm5t$ on ! difficulty 9 secur+ salv>san1 on ! moral & e?ical "q z to :e!r or n x is ju/ifiable = "o p]son to control ! output ( a drug necess>y to public heal?4 ,?is week we publi% an acc\nt ( ! action ( ! ,/4 ,l\is & ,*icago m$ical societies1 :i* are call+ on ! m$ical pr(ession to appeal to _! s5ators & congressm5 to abrogate ?is pat5t4 ,! ,j\rnal believes t ?is pat5t %\ld be abrogat$1 n alone because ! pat5tees h n suppli$ ! dem&1 n alone because !y h dictat$ to ! m$ical pr(ession :o %\ld h ! drug & h[ mu* a physician might h1 n alone because ( ! w> ) ,g]many1 n alone because ( ! special ne$s ( ! gov]nm5t at ?is "t = ! control ( v5]eal diseases1 n alone because1 z "s claim1 ! pat5t at ,wa%+ton does n correctly describe ! product1 b also because ! p :o are supply+ ?is product are *>g+ prices t are exorbitant comp>$ to ! price at :i* o!rs 9 ?is c\ntry c supply x4 ,! fact is t ! salv>san "o c obta9 today co/s #d4ej p] ampule ( #j4f gram1 :]eas ! same dose ( ars5ob5zol--a prep>ation id5tical )1 if n bett] ?an1 salv>san--co/s #b4jj at retail1 & z ,dr4 ,s*amb]g says3 8,if we are p]mitt$ to cont9ue m>ket+ ! same drug aft] ! w>1 we c sell x at #a4jj or less p] tube40 ,to abrogate ?is pat5t w\ld be do+ an injury to no "o4 ,c]ta9ly ! pat5tees ( salv>san h already reap$ _! h>ve/--& a pretty ri* "o4 ,! supply ( salv>san at a reasonable price 9 proportion to its actual co/ ( production is 9 ! int]e/ ( ! heal? ( ! entire population ( ! c\ntry1 :]eas to let matt]s re/ z !y are1 is to ! b5efit ( "o man4 ,:ile we are emphasiz+ "h ! co/1 !re is aft] all a great] "q1 & t is ! supply necess>y to help control ! ravages ( "o ( ! mo/ s]i\s diseases :i* afflict humanity today4 ,x is ! duty ( ,congress to abrogate ! pat5t on ?is prep>ation &1 incid5tally1 on all m$ic9al prep>ations ( importance4--7,editorial f ,! ,j\rnal ,a4 ,m4 ,a41 ,april #ba1 #aiag47 ,end ! ,monopoly ,! ,adamson ,bill1 kn[n z ! 8trad+ ) ! enemy act10 has rec5tly be5 pass$ by ! ,h\se ( ,repres5tatives1 is n[ be=e ! ,s5ate1 & w d\btless be enact$ into a law4 ,"o ( its clauses conf]s au?ority on ! ,f$]al ,trade ,commission to grant lic5ses to citiz5s ( ?is c\ntry to op]ate pat5ts own$ by enemy ali5s4 ,physicians are int]e/$ 9 ! bill prim>ily because x includes ! salv>san situation4 ,! mann] 9 :i* salv>san has be5 suppli$ 9 ?is c\ntry has be5 s arbitr>y & ! prices *>g$ s trem5d\sly above ! actual co/1 t we %\ld n be satisfi$ unless ! monopoly is end$ s t ! drug c be suppli$ at lea/ at a fairly mod]ate figure1 & ! old me?ods elim9at$4 ,x is to be hop$1 !re=e1 t ! ,f$]al ,trade ,commission w n grant exclusive control--t is1 exclusive lic5se--to any "o p]son or firm4 ,to d s w\ld simply p]petuate ! old monopoly & ! old conditions4 ,engl& has adopt$ a law1 :i*1 9 pr9ciple1 is simil> to ! ,adamson ,bill1 & !re sev]al conc]ns h be5 lic5s$ to manufacture ! product4 ,! same %\ld be done "h4 ,! ,d]matologic ,rese>* ,laboratories ( ,philadelphia ann\nce t !y c supply ars5ob5zol at #a4ej a tube1 & t !re is imm$iately available a supply suffici5t = any dem& t may be made4 ,! same laboratories h ann\nc$ also t 9 a few mon?s !y w be able to supply hospitals = #a4jj a tube4 ,consid]able responsibility re/s on ! ,f$]al ,trade ,commission 9 ?is matt]1 = x is n only a "q ( monopoly1 b also a "q ( sci5tific qualifications & ability to make ! product on ! "p ( "s :o may make application4 ,und\bt$ly ! commission w secure ! coop]ation ( ! ,unit$ ,/ates ,public ,heal? ,s]vice1 "u ^: sup]vision ^! drugs %\ld be manufactur$ no matt] :o %all be lic5s$ to make ! product4--7,editorial f ,! ,j\rnal ,a4 ,m4 ,a41 ,july #ba1 #aiag47 ,arsph5am9 ,no1 ?is is n a new *emical2 x is simply ! "n adopt$ by ! ,f$]al ,trade ,commission = ! hydro*lorid ( #c-;diam9o-#d-;dihydroxy-#a-;ars5ob5z5e- -9 o!r words1 salv>san4 ,z our read]s already h be5 in=m$ ?ree firms h be5 lic5s$ to manufacture & sell arsph5am92 b1 :ile ea* manufactur] may h 8 own trade "n on ! label1 ! (ficial "n mu/ be ! prom95t "o on all packages4 ,h5ce1 physicians %\ld at once make x a po9t to le>n & use ! "n 8arsph5am90 9 place ( salv>san4 ,at fir/ sight1 arsph5am9 looks =midable4 ,9 reality1 x is j z easy to famili>ize oneself ) ! ^w 8arsph5am90 z x 0 to le>n to use ! t]ms 8salv>san10 8ars5ob5zol0 or any o!r ( ! trade names4--7,editorial f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #ai1 #aiah47 ,,be] ,,& ,,canc] ,,cures ,did ! ,brew+ ,int]e/s ,adv]tise ,autolys98 ,our read]s may rememb] t an article appe>$ 9 ?is dep>tm5t ( ,! ,j\rnal = ,july #f1 #aiah1 "u ! title 8,h5ry ,smi? ,williams & #8,proteal ,!rapy4'0 8,proteal ,!rapy0 is a treatm5t exploit$ by ,h5ry ,smi? ,williams1 ,m4,d41 ( ,new ,york1 = use 9 tub]culosis1 canc]1 rheumatism1 etc4 ,x is app>5tly a modification ( ! 8,autolys90 canc] 8cure0 :i* ,williams _h previ\sly puff$ 9 ,he>t's ,magaz9e4 ,! ,j\rnal's article po9t$ out t ,h5ry ,smi? ,williams1 al?\gh entitl$ to write 8,m4,d40 aft] 8 "n1 is ess5tially a j\rnali/4 ,he has writt5 volum9\sly = "s ye>s 9 lay publications on v>i\s subjects1 bo? "u 8 own "n & "u 8 nom de plume1 8,/odd>d ,goodhue1 ,m4,d40 ,9 addition1 ,williams runs a publi%+ conc]n call$ ! ,goodhue ,company1 :i* issues a numb] ( books1 _m ( !m be+ repr9ts ( ,williams' own articles4 ,closely associat$ ) ,h5ry ,smi? ,williams is 8 bro!r1 ,edw>d ,hunt+ton ,williams1 :o also is a prolific writ]4 ,! ,j\rnal's previ\s article call$ att5tion to ! fact t !re _h be5 s5t broadca/ to physicians a neat little clo?-b\nd book1 entitl$1 8,alcohol1 ,hygi5e & ,legislation40 ,?is book1 :i* evid5tly co/ somebody a good deal ( money to di/ribute gratis1 0 publi%$ by ! ,goodhue ,company1 & 0 writt5 by ,edw>d ,hunt+ton ,williams4 ,enclos$ ) ! book 0 an adv]tis+ leaflet on ! 8,autolys90 canc] cure & also a lett] f ! ,goodhue ,company1 ask+ physicians to accept x 8) our complim5ts & ! complim5ts ( ! au?or40 ,! lett] 0 *iefly devot$ to call+ att5tion to ,h5ry ,smi? ,williams' 8new book1 ! ,autolys9 ,treatm5t ( ,canc]40 ,! la/ ?irte5 pages ( ! book 8,alcohol1 ,hygi5e & ,legislation0 conta9$ adv]tisem5ts ( ! ,goodhue ,company's publications1 p>ticul> emphasis be+ plac$ on ! 8,autolys9 ,treatm5t ( ,canc]10 by ,h5ry ,smi? ,williams4 ,s mu* by way ( retrospect4 ,n[ comes in=mation t may ?r[ an int]e/+ side-light on ! matt] j pres5t$4 ,!re is at pres5t be+ conduct$ by a committee ( ! ,unit$ ,/ates ,s5ate1 an inve/igation relative to ! pur*ase ( a ,wa%+ton 7,d4 ,c47 newspap] ) money alleg$ to h be5 furni%$ by ^? int]e/$ 9 ! brew+ indu/ry4 ,at ! op5+ he>+ be=e ! ,s5ate ,committee1 ,tuesday1 ,novemb] #ai1 ! secret>y ( ! ,unit$ ,/ates ,brew]s' ,association1 aft] admitt+ t brew]s' propag&a _h be5 publi%$ 9 ! ,int]national ,mon?ly1 edit$ by ,vi]eck 7( ! ,fa!rl&71 also decl>$ t ! ,publication ,committee ( ! brew]s' association employ$ writ]s to 8write up c]ta9 subjects0 relat+ to ! brew]s' trade4 ,"o ( ! writ]s m5tion$ 9 ?is connection 01 accord+ to ! newspap] reports1 8,dr4 ,edw>d ,h4 ,williams1 au?or ( articles publi%$ 9 m$ical & o!r j\rnals40 ,) ?is fact be=e u1 x seem$ wor? :ile to g ?r\gh ! book t _h be5 di/ribut$ s lavi%ly to physicians ) ! complim5ts ( ! ,goodhue ,company & ,dr4 ,edw>d ,hunt+ton ,williams1 9 ! exploitation ( 8,autolys910 & ,h5ry ,smi? ,williams' book on ! subject4 ,! fir/ *apt] ( 8,alcohol1 ,hygi5e & ,legislation0 consi/s ( a repr9t ( an article f ! ,new ,york ,m$ical ,j\rnal ( ,may #h1 #aiae4 ,! article is a skilful pres5tation ( ! case = ! def5d]s ( ! light] alcoholic bev]ages1 especially be]4 ,?is *apt] & all succe$+ *apt]s ( ! book attempt to discr$it prohibitory legislation1 & argue t prohibition drives ! public to ! use ( ! m ard5t alcoholic bev]ages1 :ile prev5t+ ! use ( ! mild] bev]ages1 su* z be]1 :i* "o is l$ to inf] is n p>ticul>ly h>mful4 ,?r\gh\t ! book1 also1 ! /ate ( ,kansas is held up z an example ( ! h>m done by prohibition1 & ! !me is develop$ t insanity & ! use ( coca9 & o!r habit-=m+ drugs foll[s 9 ! wake ( prohibition4 ,! foll[+ extracts are f ,*apt] ,i3 ,! evil effects ( be] & w9e1 = example1 are greatly less ?an ^? produc$ by spiritu\s liquors4444 ,italics ours4--,ed4 ,if our !ory ( immunity is correct we %\ld expect to f9d t ! old] bev]ages1 su* z be] & w9e1 :i* h be5 us$ = ?\s&s ( ye>s1 are less productive ( alcoholic insanity1 = example1 ?an ! spiritu\s liquors :i* are rec5t innovations4 ,9 po9t ( fact we f9d ?is to be ! case3 ! spiritu\s liquors are almo/ :olly responsible = all =ms ( alcoholic insanity4 ,italics ours4--,ed4 ,*apt] ,,ii is a repr9t ( an article t appe>$ 9 ,ev]ybody's ,magaz9e1 ,augu/ #aiad1 & deals ) 8,legislation f a ,m$ical ,viewpo9t40 ,x is to ! effect t drug addiction & insanity1 toge!r ) special =ms ( m5tal disease directly attributable to alcoholism1 seem to fl\ri% be/ 9 prohibition t]ritory4 ,*apt] ,,iii deals ) 8,! ,peace & ,w> ,foot+ ( ,alcohol10 & is a repr9t f ! ,m$ical ,record1 ,aug4 #g1 #aiae4 ,x1 too1 s+s ! praises ( ! 8light] bev]ages10 :ile deprecat+ ! use ( 8ard5t spirits40 ,= in/ance3 ,an ov]:elm+ly l>ge proportion ( p]sons :o develop alcoholic psy*oses 9 ,am]ica are dr9k]s ( :isky1 or "s correspond+ ard5t _s1 :]eas ?is condition is seldom se5 9 be] & w9e dr9k]s4 ,italics ours4--,ed4 ,?us we f9d ! highe/ p]c5tage ( alcohol psy*oses among ! :isky dr9k]s :o come f we/]n ,europe1 :ile ! w9e & be] dr9k+ races ( c5tral & s\!rn ,europe %[ a di/9ctly l[] p]c5tage1 9 "s in/ances only ab\t "o-f\r? z _m p] ?\s&4 ,italics ours4--,ed4 ,*apt] ,,iv deals ) 8,"s ,aspects ( ,liquor ,legislation40 ,l ,*apt] ,,ii x is an indictm5t ( prohibition1 & ! ,unit$ ,/ates ,c5sus ,bureau's reports are call$ on to su/a9 ?is !sis4 ,quotations1 too1 are made f ! writ+s ( ,h5ry ,smi? ,williams fur!r to prove ! po9t4 8,dry0 ,kansas & 8wet0 ,nebraska are frequ5tly comp>$1 to ! detrim5t ( ! =m]4 ,"o :o accepts ! /atem5ts 9 ?is *apt] w get ! impression t ,kansas has m lawlessness1 illit]acy1 paup]ism1 & insanity ?an ,nebraska4 ,*apt] ,v deals ) 8,! ,problem ( ,legislation40 ,x is bas$ on ! premise t 8prohibition does n prev5t ! consumption ( liquor10 b on ! contr>y1 8prohibitive legislation induces ! consumption ( ! mo/ h>mful =m ( liquors40 ,/at$ 9 ano!r way1 x is equival5t to *>g+ t prohibition is h>d on ! brew]s1 b b5eficial to ! di/ill]s4 ,9 fact1 ,e4 ,h4 ,williams1 9 ano!r book 78,! ,"q ( ,alcohol0--,goodhue ,co47 :i* also *ampions ! case = ! mild] alcoholics1 quotes ,h5ry ,smi? ,williams z say+1 relative to prohibitory legislation3 8,9 g5]al1 x w\ld appe> t1 if our legislators ( rec5t ye>s _h be5 9 league ) ! di/ill]1 !y c\ld n h s]v$ 8 purpose bett]40 ,:e!r or n ,edw>d ,h4 ,williams' or ,h5ry ,smi? ,williams' conception ( ! alcohol problem is good1 bad or indiff]5t1 ne$ n at ?is "t conc]n u4 ,! m$ical pr(ession1 h[ev]1 has a "r to ask two que/ions3 ,fir/1 ,is ! ,dr4 ,edw>d ,hunt+ton ,williams :o wrote 8,alcohol1 ,hygi5e & ,legislation0 ! 8,dr4 ,edw>d ,h4 ,williams0 :o 0 employ$ by ! brew]s to write propag&a favorable to ! brew+ int]e/s8 ,second1 ,0 ! clo?-b\nd book1 8,alcohol1 ,hygi5e & ,legislation10 :i* 0 di/ribut$ by ! ,williams bro!rs1 paid =1 :olly or 9 "p1 by ! ,unit$ ,/ates ,brew]s' ,association8 ,= ^? :o wi% to read ,dr4 ,edw>d ,hunt+ton ,williams' op9ion on ! alcohol "q1 ! foll[+ bibliography may be ( s]vice3 8,liquor ,legislation & ,insanity03 ,m$ical ,record #hd3gia1 #aiac4 8,! ,liquor ,"q 9 ,m$ic9e03 ,m$ical ,record #he3fab1 #aiad4 8,inebriety z a ,m$ical ,problem03 ,po/-,graduate #bi3fjc1 #aiad4 8,! ,problem ( ,inebriety03 ,n4 ,y4 ,m$ical ,j\rnal #aja3idj1 #aiae4 8,aspects ( ,inebriety 9 ,alcohol03 ,briti% ,j\rnal ( ,inebriety #ac3i1 #aiae-aiaf4 8,! ,peace & ,w> ,foot+ ( ,alcohol03 ,m$ical ,record #hh3bbf1 #aiae4 8,alcohol & ,!rapeutics03 ,m$ical ,record #ib3fff1 #aiag4--7;,f ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #cj1 #aiah47 ,,biologic ,,!rapeutics ,,& ,,its ,,comm]cial ,,dom9ation ,! dang] ( comm]cializ$ !rapeutics has be5 enorm\sly increas$ by ! introduction ( biologic products4 ,^! sub/ances (f] a ri* field = ! comm]cially m9d$1 fir/1 because ( ! rem>kable results :i* seem to h foll[$ ! use ( c]ta9 products ( ?is type2 second1 because ! field is new & ! mode ( action ( ^! sub/ances n readily und]/ood &1 ?ird--& mo/ important--because1 by ! v nature ( ! problems involv$1 few physicians are well in=m$ conc]n+ !m4 ,! influ5za epidemic ( la/ ye> 0 widespread & fatal 9 "*4 ,x /imulat$ e>ne/ rese>* 9 me?ods ( prev5tion & cure4 ,we 7 all 9 a frame ( m9d to grasp at any /raw4 ,"h & !re "s work] w\ld cry 8,eureka0--only to be disappo9t$ :5 8 product 0 actually put to ! te/4 ,h[ev]1 !re 7 m ?an en\gh manufactur]s ready to place any product on ! m>ket ) speci\s claims t c\ld n be positively d5i$4 ,vacc9es1 s]ums1 prote9s--all 7 advanc$ ) su* gl[+ /atem5ts z to _! prop]ties t only ^? physicians :o kept _! feet firmly on solid gr\nd c\ld resi/ ! appeal4 ,n[ we h _h ano!r epidemic--mild1 x is true--b ! memories ( la/ ye> make ! av]age physician ready to accept any?+ :i* promises hope1 & ! manufactur]s 8make hay :ile ! sun %9es40 ,physicians h be5 & are be+ delug$ ) lit]ature on ! prophylaxis & treatm5t ( influ5za4 ,s f> z we "k1 few publications h conta9$ any ^w ( w>n+ on ^! matt]s4 ,"o exception has j come to notice3 ! ,m$ico-,milit>y ,review1 a semimon?ly mimeograph$ publication s5t to m$ical (fic]s ( ! ,army by ! ,surgeon ,g5]al's ,(fice4 ,?is says3 ,,y ,,are ,,rem9d$ t s f> a compreh5sive analysis ( results obta9$ by ! use ( monoval5t & polyval5t vacc9es 9 ! prev5tion ( influ5za has n demon/rat$ _! value4 ,mu* c>efully controll$ exp]im5tal "w is n[ be+ c>ri$ out on ?is subject bo? 9 civil in/itutions & 9 ! ,army1 & any wor?:ile advances w be report$ 9 ! ,review f "t to "t4 ,if a prospective vacc9e is develop$1 x w be prep>$ at ! ,army ,m$ical ,s*ool = g5]al di/ribution & all m$ical (fic]s w be duly notifi$4 ,! g5]al use ( ! pres5t comm]cial polyval5t protective aga9/ influ5za is n consid]$ desirable4 ,num]\s telegrams & o!r requisitions are be+ receiv$ = influ5za vacc9e4 ,9 view ( ! fact t no prophylactic influ5za vacc9e is available1 su* requisitions %\ld be discont9u$4--7,editorial f ,! ,j\rnal ,a4 ,m4 ,a41 ,feb4 #ad1 #aibj47 ,,capell',s ,,uroluetic ,,te/ ,u4 ,s4 ,m>9e ,hospital1 ,*icago4 ,to ! ,editor3--,a memb] ( ! consultant /aff ( ?is hospital rec5tly ref]r$ to u a 8,doctor0 ,h4 ,f4 ,mat!ws1 :o 0 suppos$ to give demon/rations ( a new te/ = syphilis--8,capell's #8,uroluetic' ,te/40 ,! te/ 0 to be made ( ! ur9e ( ! pati5t4 ,! above m5tion$ consultant 0 "u ! impression t ! said 8,doctor0 ,mat!ws 0 a graduate physician4 8,doctor0 ,mat!ws came to ! hospital accord+ to ! appo9tm5t made by ! consultant1 & proce$$ to give 8 demon/ration4 ,sev]al ( ! junior (fic]s & int]ns 7 pres5t to witness x4 ,he 0 ask$ que/ions 9 an attempt to det]m9e ! sci5tific /atus ( ! te/ :i* he 0 demon/rat+4 ,8 answ]s 7 always vague & indef9ite & n clo!d 9 sci5tific words4 ,we became suspici\s ( him1 & he 0 ask$ if he 0 a graduate physician4 ,he admitt$ t he 0 n4 ,he 0 fur!r ask$ if he _h /udi$ *emi/ry & bact]iology2 he /at$ t he _h 9 #ahhh4 ,inquiry 0 made z to :]e2 he repli$ t x 0 at ! ,univ]sity ( ,ill9ois4 ,he 0 fur!r ask$ if he 0 famili> ) ! ,wass]mann reaction4 ,he /at$ t he 0 n4 ,?is man is go+ ar\nd repres5t+ himself z a physician :o has a new te/ :i* he claims is sup]ior to1 & m delicate ?an1 ! ,wass]mann te/2 yet he kn[s no?+ :atev] ( ! te*nic ( ! ,wass]mann reaction4 ,9 "o case1 we gave him ! same specim5 ( ur9e 9 f\r diff]5t conta9]s4 ,he read a diff]5t degree ( reaction = ea* ( !m4 ,9 o!r words1 9 a specim5 f ! same pati5t1 8 f\r diff]5t te/s %[$1 respectively1 a 1 a 1 a & a reaction4 ,x occurr$ to me t x might be well to in=m y ( ?is man's me?ods1 z he told u t he _h be5 to a good _m in/itutions1 & ,i am sure he w soon />t a plan to sy/ematically =ce 8 pseudosci5tific te/ on cr$ul\s physicians ev]y:]e4 ,j4 ,o4 ,cobb1 ,m4,d41 ,s5ior ,surgeon 9 ,*>ge4 ,! ,propag&a ,dep>tm5t has 9 its files a bus9ess c>d read+3 8,capell's ,laboratories1 ,room #aeaj ,masonic ,temple1 ,*icago4 ,dr4 ,h4 ,f4 ,mat!ws1 ,special ,repres5tative40 ,capell's ,laboratory has its headqu>t]s 9 ,omaha1 & is app>5tly conduct$ by ,dr4 ,w4 ,l4 ,capell1 :o1 = _m ye>s1 seems to h be5 m or less int]e/$ 9 propriet>y m$ic9es4 ,"s ye>s ago he 0 connect$ ) a conc]n kn[n z 8,acne9e ,ph>macal ,company10 :i*1 app>5tly1 0 dissolv$ "s "t 9 #aiaj2 & soon !reaft] a new company 0 organiz$ kn[n z ! ,le,roy ,drug ,company4 ,9 #aiag ,w4 ,l4 ,capell 0 connect$ ) ! ,capell1 ,cam]on ,co41 ,inc41 ( ,l9coln1 ,neb41 :i* 0 sell+ 8,capell's ,uroluetic ,te/01 8,capell's ,treatm5t = ,syphilis0 & o!r rem$ies4 ,! 8,treatm5t = ,syphilis0 0 said to be 8,pa9less1 ,pleasant1 ,h>mless1 ,efficaci\s1 & requires usually f #cj to #ij days only to eradicate ! disease40 ,! "n ( ! treatm5t is 8,m]c>od90--e>li] x 0 call$ 8,camit0--& x is n[ be+ sold f 8,capell's ,laboratory10 ,omaha4 ,9 addition1 ,capell's ,laboratory sells ,acne9e1 :i* app>5tly is ! same product t 0 sold 9 #aijf & #aijg "u ! "n ( 8,sambu-,co0 by ! ,holtman-,/r+] ,co4 ( ,omaha & lat] 0 put out by ! ,acne9e ,ph>macal ,company ( ,omaha4 ,:ile ,capell's ,laboratory sells propriet>y rem$ies1 x is ! 8,uroluetic ,te/0 :i* ! conc]n n[ seems to be featur+4 ,! claims made = ?is are3 8,?is te/ requires no exp]t k1 is inexp5sive1 & c be made 9 a few m9utes1 & is s pla9 t x _c be mi/ak540 ,! idea ( be+ able to det]m9e ! abs5ce or pres5ce ( syphilis by a simple color te/ ( ! ur9e is a fasc9at+ "o4 ,! pres5t reliable diagno/ic te/s are1 z ,capell's ,laboratory s plausibly emphasizes1 some:at involv$1 & call = r delicate te*nic4 ,b !re are no %ort-cuts to k4 ,a physician :o ord]$ ,capell's ,uroluetic ,te/ "s weeks ago receiv$ ) ! bill ! lett] t foll[s3 ,x is giv5 n s mu* = :at x says1 z = h[ x says x4 ,x is copi$ v]batim et lit]atim3 8,y\r lett] receiv$1 & we h mail$ y z p] y\r lett] #a ,doz4 ( ,capell's #8,uroluetic' ,te/s4 ,9 close f9d /atem5t & in/ructions1 = same4 8,! #8,uroluetic' ,te/ is meet+ a f> great] approval f ! ,m$ical pr(ession ?an we _h expect$1 :ile we d n claime t x is p]fect1 yet we h only receiv$ "o unfavorable report1 & we daily feel incurag$ 9 its efficacy4 8,y "k ,doctor t !re are two dang]\s elem5ts 9 ?is _w1 "o is ! extreme pessimi/ & ! o!r is ! extreme optimi/4 ,! immoral ,l9coln said1 #8,t !re 0 no?+ t 0 :olly good or :olly evil1' & we presume t ?is is equally true ( ! #8,uroluetic' te/4 ,b we want ! tru? no matt] :at x is40 8,capell's ,uroluetic ,te/0 w\ld be 8important if true40 ,un=tunately1 its sci5tific value to ! suff]] is negligible comp>$ ) its economic value to ! exploit]4 ,x is n s mu* a te/ = lues 9 ! pati5t z ( cr$ulity 9 ! doctor4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,aug4 #bc1 #aiai47 ,ano!r ,ur9>y ,te/ = ,syphilis ,to ! ,editor3--,w y k9dly in=m me :e!r ! te/ 9 ! enclos$ 8lit]ature0 is :at x is repres5t$ to be8 ,*>les ,m4 ,?omas1 ,m4,d41 ,sunbury1 ,pa4 ,,answ]4--,! 8lit]ature0 ref]r$ to by ,dr4 ,?omas dealt ) ! 8,uri-,na ,te/0 sold by ! ,/&>d ,appliance ,company ( ,philadelphia4 ,!re seems to be a /rong family resemblance betwe5 ?is alleg$ te/ & t kn[n z 8,capell's ,uroluetic ,te/10 :i* 0 discuss$ 9 ! ,propag&a ,dep>tm5t ( ,! ,j\rnal1 ,aug4 #bc1 #aiai4 ,( t ,! ,j\rnal said3 8,un=tunately1 its sci5tific value to ! suff]] is negligible comp>$ ) its economic value to ! exploit]4 ,x is n s mu* a te/ = lues 9 ! pati5t z ( cr$ulity 9 ! doctor40 ,! same may be said ( ! 8,uri-,na ,te/40 ,! facts are1 !re is no me?od at pres5t kn[n by :i* ! abs5ce or pres5ce ( syphilis may be det]m9$ by a simple color te/ ( ! ur9e4--7,qu]y 9 ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #bb1 #aiai47 ,,*emo!rapy ,,& ,,tumors,n ,ri*>d ,weil1 ,m4,d41 ,new ,york ,n ,f ! ,canc] ,rese>* ,s]vice ( ! ,g5]al ,memorial ,hospital1 ,new ,york4 ,n ,?is critical discussion ( ! /atus ( *emo!rapy 9 tumors 0 prep>$ at ! reque/ ( ! ,c\ncil on ,ph>macy & ,*emi/ry ( ! ,am]ican ,m$ical ,association4 ,)9 ! la/ ?ree ye>s a numb] ( reports h appe>$ 9 ! m$ical press :i* be> on ! treatm5t ( malignant gr[?s 9 human be+s by *emical prep>ations4 ,! mo/ p]suasive & ! mo/ insi/5t claims h be5 made 9 connection ) ! colloidal solutions ( c]ta9 metalloids & metals1 notably sel5ium1 vanadium & copp]4 ,at ! same "t a numb] ( drug h\ses1 bo? 9 ?is c\ntry & abroad1 h plac$ on ! m>ket propriet>y prep>ations ( ^! sub/ances 9 v>i\s =ms1 = :i* ! claim is made t !y produce /rik+ !rapeutic effects & sometimes ev5 cures 9 malignant neoplasms4 ,! impulse t[>d ! use & production ( ?is type ( prep>ation is directly traceable to a s]ies ( sci5tific exp]im5ts on ! tumors ( animals1 :i* date back no f>!r ?an ! ye> #aiaa4 ,9 t ye> ,wass]mann & 8 co-work]s#bfg publi%$ a report on ! treatm5t ( rat tumors by means ( ! intrav5\s injection ( sel5ium comp\nds4 ,?is pap] receiv$ wide notoriety ?r\gh its en?usia/ic diffusion by ! lay press4 ,%ortly aft]w>d ,neub]g & 8 co-work]s#bfh publi%$ _! obs]vations ^u ! !rapeutic effects ( c]ta9 metallic comp\nds4 ,! cl9ical application ( ! enc\rag+ results obta9$ by ^! au?ors 9 animal tumors foll[$ rapidly1 & up to ! pres5t "t a numb] ( pap]s h appe>$ 9 :i* ! claim is made t human tumors also may be favorably influ5c$ ?r\gh ! con/itutional use ( sub/ances simil> to ^? us$ by ,wass]mann or ,neub]g4 ,9 "s cases1 use has be5 made ( colloidal solutions ( ! heavy metals1 su* z copp]2 9 o!rs1 sel5ium comp\nds h be5 us$1 :ile 9 a ?ird set ( obs]vations ! !rapeutic ag5t repres5ts an attempt to comb9e ! virtues ( ^! two types ( !rapy by employ+ sel5ium 9 colloidal =m4 ,z an example ( ! fir/ class1 may be cit$ ! cuprase ( ,gaube du ,g]s2#bfi ( ! second1 ! sel5iovanadic o9tm5t ( ,roem] & ! sulpho-sel5e ( ,walk]2 ( ! ?ird1 sel5iol & electro-sel5ium4 #bfg ,wass]mann1 ,keyss] & ,wass]mann3 ,deuts*4 m$4 ,w*ns*r4 #cg3bchi1 #aiaa4 ,wass]mann & ,hansemann3 ,b]l4 kl94 ,w*ns*r4 #di3d1 #aiab4 #bfh ,neub]g & ,casp>i3 ,deuts*4 m$4 ,w*ns*r4 #ch3cge1 #aiab4 ,neub]g1 ,casp>i & ,lhe3 ,b]l4 kl94 ,w*ns*r4 #di3adje1 #aiab4 #bfi ,g]s1 ,gaube du3 ,la cuprase et le canc]1 ,p>is1 #aiac4 ,inasmu* z ?is new type ( canc] !rapy d]ives its orig91 its ju/ification & its support1 9 v l>ge measure1 f ! laboratory results obta9$ 9 animals1 x is a matt] ( consid]able importance to exam9e ^? results ) c>e1 9 ord] to det]m9e :e!r !y furni% a satisfactory basis = human !rapy1 & :e!r !y ju/ify ! hopes to :i* !y h giv5 rise4 ,x is safe to ass]t t ! application ( *emo!rapy to ! treatm5t ( tumors practically dates f ! publications ( ,wass]mann4 ,he /at$ ! pr9ciple t a rational !rapy ( tumors mu/ be bas$ on con/itutional treatm5t4 ,x appe>s evid5t t local treatm5t c h only local effects4 ,! lymphatic ext5sions ( tumor\s gr[?s1 & ! (t5 unsuspect$ meta/ases 9 di/ant organs mu/ ( necessity escape ! effects ( purely local treatm5t4 ,h5ce1 ,wass]mann rea*$ ! conclusion t all treatm5t ( canc] :i* 0 to be effective1 & n m]ely palliative1 mu/ be c>ri$ to all p>ts ( ! body by means ( ! blood /ream4 ,he !re=e introduc$ ! use ( intrav5\s injections 9 ! exp]im5tal !rapy ( rat & m\se tumors4 ,an accid5tal obs]vation l$ him to believe t sel5ium 0 a sub/ance possess+ a high degree ( aff9ity = tumor cells4 ,9 ord] to insure ! p5etration ( ! tumor 9 ! live animal by ?is sub/ance1 h[ev]1 he consid]$ x ess5tial to comb9e x ) "s o!r highly diffusible sub/ance4 ,?is type ( sub/ance1 :i* 0 to act z a c>ri] ( ! sel5ium1 he describ$ "u ! "n 8cytotro*910 f ! ,greek ^w tro*ia1 mean+ road4 ,= ?is purpose he select$ eos94 ,! eos9 & ! sel5ium 7 !n comb9$ by a me?od & 9 a =m ! details ( :i* h nev] be5 publi%$4 ,all t we "k ( ?is prep>ation is conta9$ 9 ! /atem5t t x is v difficult to produce1 & t x is extremely un/able & difficult to keep4 ,mice c be giv5 am\nts ( f #b to #c mg4 ( ?is sub/ance 9 solution4 ,wass]mann exp]im5t$ ) mice inoculat$ ) transplant$ tumors ( ! types ( c>c9oma & s>coma4 ,aft] f ?ree to five intrav5\s injections ( ! drug1 he not$ t ! tumors become s(t] & fluctuate4 ,aft] /ill fur!r injections ! fluid mass und]goes absorption1 & ! tumor gives ! impression ( an empty sac4 ,if x is possible to c>ry ! injections up to ! numb] ( t5 or twelve1 recov]y ensues4 ,9 su* cur$ animals !re rema9 only ! unabsorb$ portions ( ! fibr\s capsule4 ,recurr5ces 7 n obs]v$ 9 ! cur$ animals4 ,wass]mann fur!r /at$ t two spontane\s tumors 9 mice :i* _h be5 treat$ by ?is me?od pres5t$ favorable results4 ,wass]mann's orig9al pres5tation gave few exp]im5tal details1 & has n be5 foll[$ by ! promis$ sci5tific report4 ,f 8 article x is impossible to det]m9e :at proportion ( 8 animals 7 cur$ & :at proportion fail$ to survive ! treatm5t4 ,f a lat] pap] by ,keyss]#bgj we le>n t by f> ! l>g] portion ( ! animals p]i%$ dur+ ! treatm5t 9 ! /age ( s(t5+1 s t a cure 0 accompli%$ 9 f only #c to #e p] c5t4 ( ! animals4 ,?is is a po9t ( great importance1 inasmu* z x furni%es an indication ( ! highly dang]\s "* ( ?is mode ( treatm5t4 ,fatal results are attribut$ by ,keyss] to ! absorption ( toxic products f ! tumor4 ,?is cont5tion1 h[ev]1 is support$ by no obs]vations1 & x is c]ta9ly equally fair to assume t dea? results f ! toxic effects ( ! comp\nd4 ,a microscopic /udy ( tumors tak5 f animals und]go+ treatm5t 0 made by ,hansemann4 ,he f\nd t ! dea? ( ! cells 0 ! result ( nucle> de/ruction4 #bgj ,keyss]3 ,wi54 kl94 ,w*ns*r4 #bf3affd1 #aiac4 ,)9 a v few mon?s aft] ,wass]mann's publication1 ,neub]g & ,casp>i#bfh publi%$ a pap] :i* 0 ! fir/ ( a s]ies ( /udies on ! !rapeutic effects ( ! heavy metals on ! animal tumors4 ,!y us$ z9c1 plat9um1 t91 sel5ium1 copp]1 silv] & cobalt 9 ! =m ( c]ta9 complex organic comp\nds1 ! composition ( :i* is n reveal$4 ,ow+ to ! fact t intrav5\s injections ( ^! comp\nds produc$ a specific effect on ! tumors1 !y are describ$ z 8tumoraff90 sub/ances4 ,imm$iately aft] ! intrav5\s injection ( ^! prep>ations1 !re foll[$ a m>k$ hyp]emia ( ! tumor1 :]eas ! rema9d] ( ! m\se's body appe>$ m>k$ly anemic4 ,! hyp]emia 0 (t5 att5d$ by hemorrhage into ! tumor4 ,?is fir/ /age 0 succe$$ by liquefaction & absorption foll[$ by recov]y 9 favorable cases4 ,! au?ors fail$ to /ate 9 :at proportion ( _! exp]im5ts ! animals di$1 & 9 :at proportion recov]y ensu$4 ,! second pap] on ?is subject is by ,neub]g1 ,casp>i & ,lhe1#bfh 9 :i* fur!r details are v\*saf$4 ,!y /ate t ) ! comp\nds us$ by !m ! toxic & ! !rapeutic doses approximate v closely1 f :i* x foll[s t ! treatm5t1 z ) ! ,wass]mann me?od1 results 9 a v high mortality4 ,small] doses produce no !rapeutic effect2 on ! contr>y1 !y seem to act z a /imulus to ! tumor1 accel]at+ ! normal rate ( gr[?4 ,spontane\s tumors %[ simil> effects1 b no cures are record$4 ,only 9 tumors 9 :i* autolysis is active intra vitam does ! me?od ex]t any effect4 ,consequ5tly ! b5ign prim>y tumors ( animals1 su* z fibromas1 are n influ5c$ by x4 ,neub]g & ,casp>i are to a great ext5t responsible = ! colloidal !ory ( treatm5t 9 tumors4 ,accept+ ! obs]vations ( ,petri & o!rs t ! autolytic f]m5ts 9 tumors are quantitatively great] & qualitatively diff]5t f ^? pres5t 9 ! normal tissues ( ! body1 !y v5ture ! assumption t ! process ( recov]y 9 ! exp]im5tal tumors ( animals is due to ! self-dige/ion ( ! tumor by ^! f]m5ts4 ,ascoli & ,iz>#bga _h %[n t su* f]m5ts are mat]ially /imulat$ by ! pres5ce ( metals1 & m especially ( metals 9 colloidal =m4 ,?is cont5tion is app>5tly 9 h>mony ) ! well-e/abli%$ fact t c]ta9 colloidal metals ( !mselves are capable ( act+ "u c]ta9 circum/ances z f]m5ts4 ,neub]g & ,casp>i 7 at fir/ ( ! belief t ! comp\nds produc$ by !m circulate 9 colloidal =m4 ,subsequ5tly !y /at$ t ^! comp\nds 7 cry/all9e sub/ances1 b !y assum$1 "u ! influ5ce ( ! !oretical consid]ation m5tion$ above1 t ^! sub/ances are brok5 up 9 ! tumor & !re und]go trans=mation into ! colloid /ate4 #bga ,iz>3 ,zts*r4 f4 ,immunitts=s*41 #aiac4 ,iz> & ,basile3 ,b]l4 kl94 ,w*ns*r41 #aiac1 p4 #acab4 ,9 connection ) ! prec$+ obs]vations !re are c]ta9 o!r exp]im5tal results :i* require m5tion4 ,iz>#bga succe$$ 9 cur+ rat tumors by means ( injection ( colloidal sulphur4 ,c4 ,lew9#bgb cur$ subcutane\s m\se tumors ) v>i\s prep>ations ( gold4 ,w]n] & ,szcsi#bgc produc$ simil> results ?r\gh a comb9ation ( sel5ium-vanadium ) *ol9-borate2 9 ^! exp]im5ts ! sel5ium-vanadium 0 suppos$ to be pres5t 9 colloidal =m4 #bgb ,lew91 ,c>l3 ,b]l4 kl94 ,w*ns*r41 #aiac1 p4 #adg2 ,b]l4 kl94 ,w*ns*r41 #aiac1 p4 #eda4 #bgc ,w]n] & ,szcsi3 ,zts*r4 f4 ,*emo!rap41 #aiac1 ,orig41 i1 #ceh4 ,szcsi3 ,ibid41 ref41 #aiac1 ii1 #ajfj4 ,)9 a comp>atively brief p]iod ( "t1 !re=e1 x fell to ! lot ( a numb] ( obs]v]s1 us+ /rik+ly diff]5t sub/ances1 to produce !rapeutic effects am\nt+ 9 a c]ta9 p]c5tage ( cases ev5 to cure 9 ! exp]im5tal tumors ( ! l[] animals4 ,! v>i\s proc$ures h little 9 common4 ,bo? metals & nonmetallic sub/ances h be5 employ$ ei!r 9 colloidal =m or 9 comb9ation ) organic radicals4 ,9 "s in/ances a diffusible c>ri] is comb9$ ) ! basic sub/ances2 9 o!rs n4 ,all ( ! prep>ations appe> to possess a high degree ( toxicity1 al?\gh adequate data on ?is v ess5tial feature are almo/ inv>iably )held4 ,wass]mann's results ) eos9-sel5ium 7 soon critically exam9$ by o!r obs]v]s4 ,uhl5hu?#bgd & ,contam9#bge 7 unable to confirm 8 obs]vations1 b _! negative results are attribut$ by ,keyss] to ! fact t !y 7 n 9 possession ( ! prop] =mula = ! prep>ation ( ! eos9-sel5ium comp\nds z us$ by ,wass]mann4 ,apolant1#bgf h[ev]1 9 ,ehrli*'s "n confirm$ ,wass]mann's f9d+s4 #bgd ,uhl5hu?1 ,dold & ,b9dseil3 ,ref41 ,mn*54 m$4 ,w*ns*r41 #aiab1 p4 #aghb4 #bge ,contam91 ,detoeuf & ,?omos3 ,bull4 de l'assn4 fran4 p\r l'tude du canc]1 vi1 #fb4 #bgf ,apolant1 ,h43 ,,vi ,tag4 d] frei5 ,v]e9igung fr ,mikrobiologie41 ,b]l91 #aiab4 ,ref4 ,mn*54 m$4 ,w*ns*r41 #aiab1 p4 #fei4 ,! mo/ important critique ( eos9-sel5ium has be5 contribut$ by ! subsequ5t inve/igations ( "o ( ,wass]mann's orig9al collaborators1 ,f4 ,keyss]4#bgg ,keyss]'s publication conta9s a l>ge numb] ( v c>eful obs]vations on ! v>i\s =ms ( eos9 suppli$ by ! ,g]man manufactur]s1 z well z on o!r matt]s :i* _c "h be consid]$ 9 detail4 ,he f9ally rea*$ ! conclusion t ! eos9 furni%$ by ! manufactur+ h\se ( ,s&oz 0 ! mo/ effective = 8 purposes1 inasmu* z x comb9$ ! l[e/ grade ( toxicity ) ! highe/ capacity = discolor+ ! tissues4 ,! sel5ium he us$ 9 ! =m ( sel5io-vanadium furni%$ by ,cl9 ( ,p>is1 :i* 0 ! id5tical prep>ation us$ by ,w]n] & ,szcsi 9 comb9ation ) bor*ol94 ,! maximum dose ( ?is sel5io-vanadium is #j4jf c4c4 = ea* gram ( m\se4 ,eos91 #j4ja gm41 dissolv$ 9 #j4e c4c4 ( physiologic salt solution1 is mix$ ) #j4e c4c4 ( ! sel5io-vanadium4 ,?is mixture is !n us$ = intrav5\s injections4 ,! results produc$ by ! injection ( ?is mixture are to all int5ts & purposes simil> to ^? obta9$ by ,wass]mann1 except t ,keyss] induc$ cure 9 a l>g] proportion ( animals1 namely1 f #f to #h p] c5t4 ,x is evid5t f 8 c>eful description ( 8 exp]im5ts t ! treatm5t is extremely toxic to ! animals4 ,! !rapeutic dose is consid]ably great] ?an "o-half ! toxic dose4 ,?is acc\nts = ! fact t an extremely l>ge proportion ( ! animals p]i% dur+ ! c\rse ( ! treatm5t4 ,! tumors fail$ to be influ5c$ unless ! dose giv5 fell v little %ort ( ! fatal am\nt4 ,moreov]1 9 ord] to accompli% a complete cure1 at lea/ eight to t5 injections mu/ be giv51 & 9 "s in/ances n less ?an f\rte54 #bgg ,keyss]1 ,f43 ,zts*r4 f4 ,*emo!rap41 #aiad1 ,orig41 ii1 #ahh4 ,keyss]'s mo/ important conclusions1 h[ev]1 7 obta9$ by foll[+ an altoge!r diff]5t l9e ( proc$ure4 ,x has be5 po9t$ out by ,c>l ,lew9#bgb t ! !rapeutic results obta9$ f subcutane\s m\se tumors1 h[ev] enc\rag+1 c\ld n be logically appli$ to ! treatm5t ( human canc]s4 ,! subcutane\s transplant$ tumors1 z is well kn[n1 are z a rule limit$ by a di/9ct capsule & %[ no t5d5cy to infiltrative gr[?4 ,9 ?is p>ticul> !y pres5t a mo/ /rik+ diff]5ce :5 comp>$ ) human tumors4 ,on ! o!r h&1 ! meta/ases ( m\se tumors 9 ! int]nal organs pres5t an infiltrative mode ( gr[? & ?us approximate v mu* m closely to ! human type ( tumors4 ,keyss]1 !re=e1 det]m9$ to te/ ! !rapeutic effectiv5ess ( 8 comp\nds on tumors implant$ 9 v>i\s organs4 ,he develop$ a te*nic :i* enabl$ him to implant tumors 9 ! liv]1 ! sple51 ! kidneys & o!r p>ts ( ! m\se by means ( injection ?r\gh special ne$les1 (t5 )\t ! assi/ance ( a cutt+ op]ation4 ,! tumors s implant$ grew rapidly1 & )9 f two to ?ree weeks rea*$ ! size ( *]ry pits4 ,! gr[? 0 *>act]i/ically infiltrative4 ,animals ) ^! tumors 7 !n submitt$ to intrav5\s injection ( ! !rapeutic ag5ts 9 exactly ! same fa%ion z ! animals c>ry+ subcutane\s tumors4 ,! results1 h[ev]1 7 absolutely diff]5t4 ,:]eas ! subcutane\s tumors inv>iably %[$ a mu* m int5se discoloration ?an ! o!r tissues ( ! m\se1 ?is feature 0 entirely lack+ 9 ! case ( ! int]nal tumors4 ,s(t5+ & liquefaction1 :i* almo/ inv>iably foll[s on ! ?ird or f\r? injection 9 ! case ( subcutane\s tumors1 & :i* is ! fir/ symptom ( cure1 nev] pres5t$ itself 9 ! case ( ! int]nal tumors4 ,_! consi/5cy ?r\gh\t ! treatm5t 0 indi/+ui%able f t ( ! tumors ( control animals4 ,! treatm5t1 9 fact1 appe>$ to ex]cise n ! slighte/ influ5ce on int]nal tumors4 ,!re 0 nei!r cessation nor ret>dation 9 gr[?1 b ! tumors cont9u$ _! normal rate ( de/ructive increase ) ! production ( meta/ases1 lead+ ev5tually to ! dea? ( ! animal ei!r dur+ ! c\rse ( ! treatm5t or %ortly !reaft]4 ,microscopic *anges1 su* z _h be5 obs]v$ by ,hansemann 9 ! case ( subcutane\s tumors1 7 entirely lack+4 ,no matt] 9 :at organ ! tumors 7 implant$1 ^! results rema9$ ! same4 ,no matt] :at type ( tumor 0 employ$1 :e!r c>c9oma1 ad5oc>c9oma or s>coma1 ! !rapeutic outcome 0 regul>ly & consi/5tly nil4 ,^! results induc$ ,keyss] to det]m9e :e!r or n eos9-sel5ium c\ld actually be %[n to ex]cise a delet]i\s effect on canc] cells outside ! body4 ,9 ord] to d ?is he made a susp5sion ( m\se tumor cells 9 salt solution & mix$ ?is ) ! eos9-sel5ium-vanadium1 us+ ! latt] 9 am\nts equival5t to ?ree times ! fatal dose = a m\se4 ,aft] ! mixture _h /ood f "o to ?ree h\rs1 x 0 inject$ ei!r subcutane\sly or intrav5\sly into mice 9 ord] to te/ ! vitality ( ! cells4 ,9 e in/ance ! injections result$ 9 ! production ( tumors :i* c\ld be 9 no way di/+ui%$ f ! tumors produc$ by untreat$ canc] cells4 ,9 o!r words1 ! !rapeutic prep>ation _h absolutely no effect on ! tumor cells4 ,9 ! same way ,keyss] c>ri$ out exp]im5ts along ! l9es inaugurat$ by ,neub]g1 us+ a comb9ation ( glycocoll & copp]4 ,he also te/$ ! comb9ation ( bor*ol9 ) sel5ium-vanadium us$ by ,w]n] & ,szcsi4 ,he 0 able to confirm ! fact t bo? ( ^! sub/ances produc$ an unmi/akable !rapeutic effect on subcutane\s tumors4 ,on ! o!r h&1 !y 7 absolutely )\t influ5ce on ! int]nal tumors4 ,9 ?is respect1 !re=e1 !y 7 entirely comp>able ) ! eos9-sel5ium comp\nd4 ,! !oretical basis con/ruct$ by ,neub]g1 :i* re/s on ! assumption t ! metallic comp\nds /imulate autolytic processes 9 ! tumors1 0 also subject$ by ,keyss] to de/ructive criticism4 ,f9ally1 ,keyss] %[$ t none ( ^! !rapeutic ag5ts 7 effective ev5 9 ! case ( subcutane\s tumors1 unless ! latt] _h rea*$ at lea/ ! size ( *]ry pits4 ,if a !rapeutic injection 7 made imm$iately aft] inoculation ( ! tumors1 no effect 0 obs]v$4 ,! tumors grew exactly z 9 ! control animals1 & ! inject$ animals di$ 9 ab\t ! same p]iod ( "t z !y4 ,all ( ^! facts1 :i* tak5 toge!r con/itute a v rem>kable & conv9c+ piece ( sci5tific inve/igation1 p]mit ( b "o conclusion4 ,x is q cle>ly e/abli%$ t none ( ! prep>ations ( :i* ! !rapeutic effectiv5ess has hi!rto be5 proclaim$ ex]cise any direct influ5ce on ! life or developm5t ( ! tumor4 ,"u c]ta9 v def9ite & re/rict$ conditions1 h[ev]1 !y d appe> to produce c]ta9 *anges 9 ! tumors1 & 9 a small proportion ev5 cures4 ,^! results1 h[ev]1 are obta9$ only 9 ! case ( tumors :i* are subcutane\s 9 location & n small] ?an a *]ry pit 9 size4 ,keyss]'s int]pretation ( ! /rik+ diff]5ces betwe5 tumors is ( int]e/ 9 ?is connection4 ,he believes t ! con/ant palpation & exam9ation ( ! subcutane\s tumors1 :i* is prompt$ by int]e/ 9 ! exp]im5t1 produces circulatory *anges ) hyp]emia & hemorrhage4 ,^! circulatory *anges are responsible = ! increas$ t5d5cy ( ! inject$ sub/ances to lodge 9 ! tumors1 !reby possibly increas+ ! t5d5cy to autolysis :i* ! circulatory *anges h inaugurat$4 ,x is1 ( c\rse1 que/ionable :e!r ?is explanation c be reg>d$ z f9al4 ,9 a s]ies ( exp]im5ts :i* ,i p]=m$ _m ye>s ago1 ,i 0 able to %[ t sodium iodid :5 inject$ intrav5\sly accumulates 9 tumors 9 l>g] am\nts ?an 9 any o!r tissue ( ! body 9 rats4 ,a simil> obs]vation has be5 record$ by ,wells1 ,de ,witt & ,corp]4#bgh ,9 ! same way ,i f\nd t v>i\s dyes1 su* z ,congo r$1 :5 inject$ intrav5\sly1 c\ld be demon/rat$ 9 tumors long aft] ! re/ ( ! body _h recov]$ its normal color2 ! liv] alone vi$ ) ! tumors 9 ?is respect4 ,! dye/uff 0 inv>iably %>ply localiz$ 9 ! necrotic portions ( ! tumor4 ,! conclusion seem$ obvi\s t1 ow+ to circulatory conditions or possibly ev5 to *emical conditions1 ! dye 0 reta9$ longe/ 9 ! necrotic p>ts ( ! tumor4 ,?is effect 0 unque/ionably n due to h&l+1 inasmu* z ! animals 9 my exp]im5ts 7 n palpat$ f ! "t ( injection until dea?4 #bgh ,wells1 ,h4 ,g41 ,de ,witt1 & ,corp]3 ,zts*r4 f4 ,*emo!rap41 #aiad1 ,orig41 ii1 #aaj4 ,i h1 h[ev]1 _h an ev5 m /rik+ demon/ration ( ! same fact4 ,i h giv5 intrav5\s injections ( dyes to pati5ts suff]+ ) v>i\s =ms ( int]nal tumors1 z1 = example1 canc] ( ! brea/1 9 ! hope ( favorably influ5c+ ! gr[?s4 ,at op]ation1 ! picture pres5t$ by ! tumor is /rik+ 9 ! extreme4 ,x pres5ts areas ( v>i\s size :i* are int5sely discolor$ by ! dye4 ,^! areas1 bo? to ! nak$ eye & "u ! microscope1 are ! necrotic p>ts ( ! tumor4 ,! actively gr[+ areas ( tumor tissue & all ! normal tissues ( ! organ pres5t _! normal color4 ,all ( ^! obs]vations lead to ! conclusion t ! necrotic areas 9 tumors ei!r possess a high] aff9ity = sodium iodid & = ! dyes ?an d ! normal tissues1 or t ^! sub/ances are m sl[ly absorb$ f ! necrotic areas ow+ to ! circulatory defici5cy4 ,:i*ev] ( ^! explanations is accept$1 x is q reasonable to believe t necrotic areas might well und]go liquefaction "u ! influ5ce ( ! v>i\s sub/ances :i* h be5 us$ = !rapeutic injection4 ,su* a result is1 ( c\rse1 )\t direct effect on ! gr[? or vitality ( ! liv+ "p ( ! tumor4 ,?is fact is q cle>ly evid5c$ by ! exp]im5tal data1 :i* %[ t ! int]nal portions ( ! tumor might und]go liquefaction & yet ! tumors 7 n cur$4 ,inde$1 ,lhe1 :o made microscopic exam9ations ( ! tumors treat$ by ,casp>i & ,neub]g1 /ates p>ticul>ly1 ) ref]5ce to a tumor :i* _h be5 subject$ to treatm5t1 t 8! c5tral portion ( ! tumor %[$ s(t5+1 :ile ! ext]nal m>g9 0 compos$ ( actively gr[+ cells40 ,! c5tral portions ( implant$ tumors are1 ( c\rse1 ^? :i* fir/ und]go spontane\s necrosis4 ,x /ill rema9s to expla9 ! small p]c5tage ( cures a*iev$ by ,wass]mann & by ,keyss]4 ,x does n appe> to me t ?is problem pres5ts any insup]able difficulties4 ,! fact mu/ be emphasiz$ t practically #ie p] c5t4 ( ! animals die "u ! treatm5t1 :i* suffici5tly indicates ! toxic effects ( ! ag5t us$4 ,we mu/ rememb] t transplant$ tumors are "u all circum/ances at a c]ta9 disadvantage z comp>$ ) ! normal tissues ( ! body4 ,aft] all1 !y are implant$ on a =eign soil4 ,_! blood supply is impov]i%$ & imp]fect4 ,!y h a natural t5d5cy to und]go necrosis1 & 9 _m cases spontane\s retrogression4 ,x is n /range1 !re=e1 t !y %\ld prove 9 slight degree m susceptible to toxic effects ?an are ! normal tissues ( ! body4 ,if we rememb] t ! v>i\s !rapeutic ag5ts introduc$ 9 all probability rea* a some:at high] degree ( conc5tration 9 ! necrotic areas ( ! tumor ?an 9 ! normal tissues ( ! body1 an assumption :i* is entirely 9 accord ) ! facts z obs]v$ 9 ! case ( sodium iodid & ( v>i\s dyes1 we may be q prep>$ to believe t ?is factor is suffici5t to induce ! de/ruction ( ! m>g9al heal?y & liv+ cells ( ! tumor4 ,! fact t small subcutane\s tumors 7 f\nd by ,keyss] to be entirely refractory to ! treatm5t is entirely 9 accord ) ?is assumption1 9 view ( ! fact t tumors ( ?is size pres5t practically no c5tral necrosis4 ,! same explanation holds ( ! obs]vation previ\sly cit$ f ,casp>i t ! prim>y spontane\s tumors ( animals d n yield to ! treatm5t4 ,inde$1 he himself /ates t ! treatm5t is effective only 9 tumors 9 :i* autolysis takes place dur+ life4 ,! ^w autolysis1 h[ev]1 9 ?is connection is a misnom] & repres5ts a gratuit\s assumption2 z an actual fact1 "o is entitl$ to say only t su* tumors und]go c5tral necrosis1 9 all probably ow+ to defective circulatory supply4 ,! process is exactly simil> to ! coagulation necrosis describ$ 9 ! case ( tub]cles by ,weig]t4 ,if autolysis occurs1 x is only second>y to ! prec$+ necrosis4 ,?is explanation1 h[ev]1 is confront$ by ! fact t ! int]nal tumors produc$ by ,keyss] %[$ no t5d5cy to effect a localization ( ! dyes1 & correspond+ly no t5d5cy to be affect$ by ! !rapeutic ag5ts4 ,"o might be p]mitt$ to inquire :e!r ^! int]nal tumors _h und]gone any necrosis4 ,keyss] un=tunately makes no m5tion ( ?is matt]4 ,x is c]ta9ly true t ! infiltrative mode ( gr[? ( ! int]nal tumors1 :i* is entirely diff]5t f t ( ! subcutane\s implantations1 is associat$ ) a mu* bett] blood supply & a less5$ t5d5cy to und]go necrosis4 ,t su* tumors c und]go necrosis1 h[ev]1 is evid5c$ by c]ta9 illu/rations giv5 by ,c>l ,lew9 9 8 pap] on int]nal tumors4 ,b su* *anges usually occur only 9 advanc$ /ages4 ,to judge f 8 plates1 ,keyss] work$ ) relatively small tumors1 an assumption :i* is r5d]$ ev5 m likely by ! fact t 8 injections 7 und]tak5 9 a fairly e>ly /age ( _! gr[?4 ,9 ?is connection ,i may quote c]ta9 exp]im5ts ( my own on int]nal tumors4#bgi ,! implantations made 9 my exp]im5ts 7 produc$ by intrav5\s injections ( a tumor susp5sion into ! jugul> ve9 ( rats4 ,su* injections result$ almo/ inv>iably 9 ! production ( a l>ge numb] ( tumors 9 ! lungs1 :i*1 z is well %[n 9 ! figures accompany+ ! orig9al article1 diff]$ v m>k$ly 9 size4 ,! small] ( ^! tumors are compos$ ?r\gh\t ( actively gr[+ cells1 :ile ! l>ge tumors pres5t an area ( c5tral necrosis exactly z d ! subcutane\s tumors4 ,if su* an animal be giv5 an intrav5\s injection ( a dye su* z ,congo r$1 x w be f\nd t ! l>g] tumors pres5t an area ( c5tral discoloration correspond+ to ! area ( previ\s necrosis1 :ile ! small] tumors1 l normal tissues1 are n color$4 ,?us1 x is cle> t ! int]nal tumors implant$ 9 animals are subject to ! same laws conc]n+ ! di/ribution ( dyes &1 ( c\rse1 o!r sub/ances z are ! subcutane\s tumors4 ,z ,i h /at$ previ\sly1 an exactly analog\s obs]vation has be5 made 9 a human brea/ tumor4 ,9 ! abs5ce ( any contradictory evid5ce1 !re=e1 ,i ?9k t x is p]fectly ju/ifiable to assume t ,keyss] fail$ to a*ieve a result 9 ! int]nal gr[?s simply ow+ to ! fact t ^? gr[?s pres5t$ practically no areas ( necrosis at ! "t ( 8 injection4 #bgi ,j4 ,m4 ,rese>*1 #aiac1 p4 #dig4 ,ano!r !oretical "q :i* be>s closely on ! rec5t !rapeutic inve/igations 9 human be+s conc]ns ! rle ( colloids1 z su*1 9 ! proc$ure4 ,x is q cle> f :at has already be5 said t all exp]im5ts ) animal tumors h be5 l>gely influ5c$ by ! belief t metals 9 ! colloidal =m ex]cise a peculi> & *>act]i/ic influ5ce on ! de/ruction ( tumors4 ,ev5 :5 ! !rapeutic ag5ts h be5 introduc$ 9 cry/all9e =m1 z by ,neub]g & ,casp>i1 ! au?ors f9d !mselves compell$ to assume t ! metals are r$uc$ to colloidal =m )9 ! tumors4 ,= ! latt] assumption !re is absolutely no evid5ce2 x is due simply to ! influ5ce ( ! colloidal !ory4 ,if "o critically exam9es ! data on :i* ?is !ory is bas$1 "o is =c$ to ! conclusion t x has practically no e/abli%$ claim to validity4 ,if we grant t colloidal metals h be5 %[n to /imulate autolysis 9 ! te/ tube1 ! same fact mu/ be admitt$ ( metals 9 noncolloidal solution4 ,! exp]im5ts1 h[ev]1 are v f> f e/abli%+ ei!r ( ^! facts satisfactorily4 ,b ev5 7 ?is ! case1 x is an unju/ifiable inf]5ce t liv+ tumor cells w\ld be influ5c$ 9 any?+ l ! same mann] z are ! dead cells obs]v$ 9 te/ tube exp]im5ts4 ,z an actual fact1 we "k f ! "w ( ,evans & ,s*ulemann t only ! 8scav5g] cells0 ( ! body take up =eign colloids1 & to ?is class ! tumor cells d n belong4 ,moreov]1 ! =m 9 :i* metals are introduc$ into ! circulation is n necess>ily or ev5 probably ! =m 9 :i* !y act on ! tissues4 ,colloidal solutions ( ! metals are c]ta9ly subject to precipitation & o!r *anges on ent]+ ! blood4 ,?is fact ,i h %[n exp]im5tally 9 a previ\s /udy on colloidal copp]4#bhj ,9 ! same way x is probable1 z has be5 po9t$ out by ,wells1 t metals :5 introduc$ 9 cry/alloid =m may rapidly be alt]$ s t !y are c>ri$ ?r\gh\t ! body 9 colloidal =m4 ,all ( ^! consid]ations indicate h[ unju/ifiable is ! assumption t colloidal metals ex]cise a peculi> action on gr[+ tumors4 ,x is h>dly surpris+ t _! empiric use has fail$ to measure up to expectations bas$ on s slim a f\ndation ( fact4 #bhj ,weil1 ,ri*>d3 ,! ,effects ( ,colloidal ,copp] ) an ,analysis ( ! ,!rapeutic ,crit]ia 9 ,human ,canc]1 ,j4 ,a4 ,m4 ,a4 #fa3ajcd 7,sept4 #bg7 #aiac4 ,,cl9ical ,,obs]vation ,cl9icians h n be5 sl[ 9 foll[+ ! lead sugge/$ by ! !rapeutic exp]im5ts 9 animals4 ,x is p]fectly prop] t ?is %\ld be ! case4 ,9 deal+ ) a disease ( ! "* ( canc]1 9 _m in/ances entirely beyond our p[] to influ5ce1 no "o c "q ! advisability ( try+ any & e ag5t :i* holds out ! slighte/ promise4 ,un=tunately1 a clos] analysis ( ! animal exp]im5ts fails to v9dicate ev5 t degree ( fai?4 ,:5 "o consid]s ! facts :i* h be5 analyz$ 9 ! prec$+ discussion1 x w\ld appe> n only futile b actually dang]\s to attempt to b5efit canc] suff]]s by means ( any ( ! ag5cies :i* h be5 employ$ 9 animal exp]im5tation4 ,nev]!less1 ! fact rema9s t a v>iety ( prep>ations h be5 us$ 9 ! human cl9ic4 ,! v>i\s types ( prep>ations may be satisfactorily gr\p$ "u f\r classes1 namely3 #a4 ,! cry/all9e salts ( sel5ium4 #b4 ,sel5ium 9 colloidal solution4 #c4 ,o!r metals 9 colloidal solution4 #d4 ,comp\nds ( metals ) organic radicals4 ,^! sub/ances h be5 adm9i/]$ by injection or by ! m\?4 ,9 ! case ( injection1 ! injections h be5 made ei!r into ! subcutane\s tissues1 intramuscul>ly1 or intrav5\sly1 or f9ally1 directly into ! tumors4 ,be=e pass+ to a fur!r consid]ation ( ?is subject 9 detail1 x may be well to recall ! fact t 9 ! exp]im5tal tumors ( animals1 no matt] :at prep>ation has be5 us$1 x has be5 possible to accompli% !rapeutic effects only by ! use ( relatively enorm\s doses ( ! m$icam5t1 ( doses1 9 fact1 :i* 7 sc>cely l[] ?an ! le?al dose4 ,c]ta9 exp]im5t]s h not$ t small] doses actually /imulat$ ! gr[? ( ! tumors4 ,9 ! second place1 x has almo/ inv>iably be5 f\nd necess>y to adm9i/] ! treatm5t intrav5\sly1 inasmu* z ! o!r modes ( adm9i/ration fail$ ( !rapeutic effect4 ,x is q app>5t t a proc$ure 9 human be+s 9 any degree analog\s to t pursu$ 9 animals is entirely impossible4 ,! doses us$1 ) "o notable exception to be subsequ5tly m5tion$1 h inv>iably be5 relatively small4 ,h5ce x is app>5t at ! outset t at lea/ "o fundam5tal condition ( success 9 ! treatm5t ( animal tumors has be5 necess>ily exclud$ 9 ! cl9ical application4 ,! salt us$ by ,wass]mann is n /at$ 9 8 orig9al publication4 ,wolff#bha speaks ( x z a sodium salt1 :]eas ,keyss] says t x 0 a comb9ation ) potassium cyanid4 ,9 only "o in/ance1 z f> z ,i am aw>e1 has ! sodium salt be5 us$ !rapeutically 9 human be+s4 ,delbet#bhb /ates t he employ$ ?is salt intrav5\sly 9 "o case1 & t its use 0 %ortly foll[$ by dea?4 ,unque/ionably ! salts ( sel5ium are v mu* too toxic to be us$ 9 ?is way4 #bha ,wolff3 ,die ,lehre von d] ,krebs ,krankheit #c3aiac4 #bhb ,delbet1 ,p43 ,bull4 de l',assn4 fran4 p\r l'tude du canc] #e3aba1 #aiab2 ibid4 #f3he1 #aiac4 ,! majority ( ^? :o h work$ ) sel5ium h us$ x 9 colloidal =m1 ei!r prep>+ x !mselves or employ+ "o ( ! prep>ations put on ! m>ket by ! ph>maceutic firms4 ,( ! latt] ! be/ kn[n are ! electro-sel5ium ( ,cl91 & ! ,sel5iol ( ,c\turieux4 ,( ^? :o h made use ( sel5ium 9 ^! =ms may be m5tion$ ,cade & ,gir>d1#bhc ,b\geaut & ,galliot1#bhd ,blum5?al1#bhe ,?iroloix & ,lanci51#bhf ,delbet1 ,laur5t & ,bohec1#bhg & mo/ ext5sively ( all1 ,m4 ,t\*e4#bhh ,all ( ^! au?ors h describ$ cases ( malignant new gr[?s ( ! mo/ v>i$ "* :i* 7 treat$ by ^! prep>ations4 #bhc ,cade & ,gir>d3 ,bull4 ,soc4 md4 d4 hp4 de ,lyon #aa3cig1 #aiab4 #bhd ,b\geaut & ,galliot3 ,cl9ique1 ,p>is #g3eja1 #aiab4 #bhe ,blum5?al1 ,a43 ,j\r4 md4 de ,bruxelles1 #aiab1 #ag3cbe2 ,presse md4 belge #fe3iai1 #aiac4 #bhf ,?iroloix & ,lanci51 ,a3 ,bull4 et mm4 ,soc4 md4 d4 hp4 de ,p>is #cc3aig1 #aiab4 #bhg ,laur5t1 ,m41 & ,bohec1 ,j43 ,m$4 ,press & ,circul> #id3dfa1 #aiab4 #bhh ,t\*e1 ,m43 ,bull4 et mm4 ,soc4 md4 d4 hp4 de ,p>is #ce3dea1 #aiac4 ,! results obta9$ are fairly concordant4 ,! intrav5\s injection ( ! prep>ation produces b slight di/urbance4 ,!re is leukocytosis1 a mod]ate rise ( temp]ature1 & n infrequ5tly a *ill4 ,o!rwise ! sub/ance seems to possess no toxicity4 ,! effects produc$ on ! tumors h almo/ inv>iably be5 describ$ z enc\rag+4 ,t\*e1 :o treat$ tw5ty-sev5 cases 9 ?is way & has describ$ ea* case 9 detail1 /ates t "u ! treatm5t ! surface ( ! tumors1 if ulc]at$1 became clean] & heal?i]2 ! tumors became s(t]2 ! rate ( gr[? 0 arre/$1 & !re 0 relief ( pa9 & ( ! accompany+ functional di/urbances2 (t51 too1 !re 0 a ga9 9 weight & an improvem5t 9 g5]al well-be+4 ,t\*e concludes 8 article ) ! /atem5t t 8x is c]ta9 t ! effect is n curative b x is actually palliative40 ,delbet1 on ! o!r h&1 /ates t he has se5 no b5eficial effects f ! use ( colloidal sel5ium inject$ intrav5\sly4 ,9 ! discussion on ,delbet's pap]1 ,l$\x-,leb>d /ates t he has obs]v$ no?+ f sel5ium fur!r ?an ! tempor>y improvem5t :i* is %[n by almo/ all canc] cases on ! application ( any new !rapeutic measure4 ,9 "o or two in/ances ! claim is made 9 ! lit]ature ( an actual cure ( malignant gr[? ?r\gh ! use ( sel5ium4 ,su*1 = example1 is ! case describ$ by ,blum5?al4 ,f ! cl9ical description ?is might h be5 a canc] ( ! tongue1 & 0 judg$ to h be5 su* 9 view ( ! negative ,wass]mann reaction4 ,no microscopic exam9ation 0 made4 ,arsph5am9 0 giv54 ,! pati5t recov]$4 ,x is cle> t in/ances ( ?is type _c be accept$ z beyond criticism1 & x is safe to say t no?+ m conv9c+ 9 ! way ( actual cure is (f]$ 9 ! r volum9\s lit]ature on ! use ( sel5ium4 ,num]\s comp\nds ( sel5ium1 "s ( !m claim+ to circulate 9 colloidal =m1 h be5 describ$1 & h be5 put on ! m>ket = use 9 malignant disease4 ,su* are ,walk]'s sulpho-sel5e1 & sel5io-vanadium1 :i* has be5 prep>$ 9 ! =m ( an o9tm5t by ,s*]+ & ,glatz4 ,^! prep>ations lay claim to ! same palliative effects :i* h be5 previ\sly describ$ = colloidal sel5ium4 ,( ! o!r metals 9 colloidal =m1 *iefly silv] & copp] h come into use4 ,colloidal silv] 0 fir/ recomm5d$ = malignant gr[?s by ,vogel4 ,x is obta9able on ! m>ket 9 propriet>y =m "u ! "n ( fulm>g91 & also z electr>gol4 ,rec5tly ,rohd5burg#bhi has made a c>eful /udy ( ! effects ( colloidal silv] 9 exp]im5tal & 9 human tumors1 & f9ds t !y h no value4 ,colloidal copp] has be5 us$ 9 rec5t times = ! same purpose by ,gaube du ,g]s & by o!rs4 ,i h rec5tly exam9$ ! effects ( colloidal copp] on malignant tumors 9 man1 & h be5 unable to f9d t x has any !rapeutic value4 ,fur!rmore1 a /udy ( ! di/ribution ( ! copp] 9 tumors obta9$ at op]ation or by necropsy f individuals s treat$ fail$ to %[ t ! copp] _h be5 deposit$ !re94 #bhi ,rohd5burg1 ,h43 ,j4 ,m4 ,rese>* #bf3cca1 #aiae4 ,f9ally1 prep>ations simil> to ^? us$ by ,w]n] & by ,casp>i 9 animals h also be5 us$ 9 human be+s4 ,9 ^! cases also ! au?ors h be5 able to record palliative effects on ! tumor1 b 9 no in/ance cures4 ,we h se5 t x has be5 q impossible to duplicate 9 human be+s ! !rapeutic te*nic employ$ 9 animal exp]im5ts4 ,we h se5 fur!r t ! use ( a modifi$ te*nic 9 animal exp]im5tation has nev] be5 productive ( favorable results ev5 at ! h&s ( en?usia/ic adh]5ts4 ,9 /rik+ contra/ to ^! conclusions are ! obs]vations made 9 human !rapeutics4 ,= e type ( prep>ation describ$ 9 ! prec$+ p>agraphs1 ! claim has be5 made practically )\t exception t x ex]cises a m>k$ly b5eficial effect on malignant diseases 9 ! human be+4 ,n only are ! subjective symptoms alleviat$1 b also ! tumors appe> to become clean] & s(t]2 ! rate ( gr[? is ret>d$2 necrosis & meta/asis are prev5t$1 & inop]able tumors become op]able4 ,h[ are we to int]pret ^! obs]vations8 ,h[ are we to expla9 ! fact t !y are ! almo/ inv>iable accompanim5t ( ! mo/ div]se me?ods ( treatm5t8 ,i h already quot$ ! /atem5t ( ,l$\x-,leb>d t e !rapeutic novelty appe>s to ex]cise a favorable effect on canc] cases4 ,! same fact has be5 obs]v$ 9 a v>iety ( o!r diseases1 su* z locomotor ataxia4 ,9 ord] to arrive at a safe & reliable e/imate z to ! value ( any new or exp]im5tal proc$ure 9 cases ( canc]1 x seems advisable to accept c]ta9 def9ite !rapeutic crit]ia by :i* ! cases are to be judg$4 ,9 ! abs5ce ( su* a me?od1 alt]ations 9 symptoms :i* are actually ( no real value or importance receive undue emphasis4 ,! natural c\rse ( ! disease is associat$ ) su* fluctuations t a sangu9e !rapeuti/ c ga9 "s enc\ragem5t f ev5 ! mo/ hopeless cases4 ,h5ce x foll[s t e mode ( treatm5t has f\nd adh]5ts4 ,! m>ket is flood$ ) canc] drugs1 & canc] *>latans fl\ri% 9 ! mo/ highly educat$ communities4 ,un=tunately1 ev5 well tra9$1 hone/ & reputable physicians h fall5 victims to ?is fallacy1 & h l5t _! names to ! support ( modes ( treatm5t :i* 9 reality produce no det]m9able effect on ! natural evolution ( ! disease4 ,x 0 ! desire to combat ?is un=tunate t5d5cy :i* l$ me "s "t ago to attempt to e/abli% a reliable set ( crit]ia ( !rapeutic effects 9 canc]4 ,^! 7 embodi$ 9 an article#bhj :i* appe>$ two ye>s ago1 & ,i may be "h p]mitt$ to quote !m 9 ext5so3 ,,crit]ia ,,( ,,!rapeutic ,,effects ,9 det]m9+ ! effects ( any giv5 mode ( treatm5t on a tumor1 a v>iety ( crit]ia may be reli$ on4 ,circulatory *anges 9 ! tumor1 ! relief ( pa9 & ! re/oration ( a second>ily impair$ function are c]ta9 ( ! crit]ia on :i* /ress has be5 laid by ! majority ( obs]v]s 9 ! pa/4 ,important z are ^! crit]ia 9 det]m9+ ! progress ( purely inflammatory processes1 x is unque/ionable t _! value 9 judg+ ( ! effects ( !rapeutic me?ods :5 appli$ to malignant disease is op5 to criticism4 ,x is a curi\s & int]e/+ fact t almo/ e !rapeutic claim made 9 rec5t ye>s 9 connection ) canc] has includ$ among its virtues ! relief ( pa94 ,?is is true ( vacc9ation ) canc] tissue1 ( ,hod5pyl's me?od & ( _m o!rs4 ,9 view ( ?is v g5]al effect1 n mu* /ress c be laid on ?is symptom1 & x is probably fair to assume t 9 ! great majority ( ^! cases ! result is 9 no small measure psy*ic4 ,! improvem5t ( function is also l>gely a subjective ph5om5on1 & z su* requires mo/ c>eful criticism4 ,osl] relates t he has kn[n a pati5t ) ga/ric canc] to be reliev$ ( dige/ive di/urbances & to ga9 #ah p\nds 9 weight z ! result simply ( ! visit ( a sangu9e consultant :o d5i$ ! pres5ce ( a tumor4 ,improvem5t 9 ! ability to *ew food1 to articulate words or to move a limb are ph5om5a famili> to ^? :o attempt to treat cases ( canc]4 ,! victims ( ?is disease seem to be 9 a v high degree 8sugge/ible0 & impressionable & respond nobly to e !rapeutic ef=t4 ,circulatory *anges 9 tumors (f] an int]e/+ gr\p ( cl9ical symptoms4 ,! obs]vation has (t5 be5 made1 especially 9 ulc]at$ new gr[?s1 t treatm5t is associat$ ) swell+1 p]iph]al hyp]emia1 & an alt]$ "* ( ! dis*>ge4 ,9 spite ( ! fact t !re is no reasonable relation%ip betwe5 ?is cong]ies ( symptoms & ! actual cure ( ! tumor1 !y g5]ally receive consid]able emphasis & are cit$ z an indication ( ! specific local action ( ! ag5t employ$4 ,x is also true1 h[ev]1 t ! gr[? may cont9ue to advance 9 spite ( _! pres5ce4 ,x is ( "s importance to inquire into ! me*anism :i* produces ^! circulatory *anges & into _! cl9ical int]pretation4 ,x is a well kn[n fact t _m drugs1 :5 introduc$ into ! body ei!r by ! m\? or ?r\gh ! sk91 are excret$ n only by ! normal *annels ( elim9ation1 su* z ! kidney or ! inte/9e1 b also f su* ulc]at$ surfaces z may be pres5t on ! body4 ,?is is easily %[n to be true1 = example1 ( c]ta9 ( ! anil9 dyes1 :i*1 :5 introduc$ by way ( ! ve9s1 produce an int5se discoloration ( ! dress+s ov] ulc]s4 ,x is likewise true ( c]ta9 ( ! metals1 su* z ars5ic4 ,9 ord] to und]/& ! s]ies ( ev5ts previ\sly enum]at$ x is !re=e only necess>y to assume t ! !rapeutic ag5t is excret$ f ! ulc]at$ surface ( tumors4 ,if an irritant1 x w t5d to produce hyp]emia ( ! m>g9s ( ! ulc]1 & an increase ( ! secretions4 ,if an a/r+5t1 h[ev]1 x may produce j ! opposite ( ^! effects4 ,su* a result1 h[ev] /rik+1 is purely accid5tal1 & has no necess>y be>+ on ! gr[? or de/ruction ( ! tumor itself4 ,x con/itutes a symptom on :i* no reliance %\ld be plac$4 ,exclud+ f consid]ation all ( ^! second>y factors1 we may conclude t ! obs]vation ( ! size ( ! tumor itself is ! sole crit]ion on :i* we c place reliance 9 judg+ ( ! effect ( !rapeutic measures4 ,?is implies1 9 ! fir/ place1 t a tumor mu/ be accessible to fairly accurate measurem5t4 ,tumors ( ! ut]us1 = example1 & intra-abdom9al gr[?s w only exceptionally fall into ?is class4 ,9 ! second place1 indirect evid5ce ( a decrease 9 ! size ( tumors1 su* z is af=d$ by ! increas$ p]meability ( ob/ruct$ passages1 z 9 ! case ( tumors ( ! esophagus1 pylorus or inte/9e1 mu/ be accept$ only ) great res]ve4 ,remissions 9 ! ob/ructive symptoms *>act]i/ic ( su* tumors are a frequ5t feature ( ! normal evolution ( ! cl9ical hi/ory ( su* gr[?s4 ,! relief ( ob/ruction1 h[ev]1 may be due ei!r to necrosis ( ! ob/ruct+ portions ( ! tumor1 :ile ! rema9d] cont9ues to gr[ progressively1 or to a relief ( ! accompany+ muscul> spasm4 ,f9ally1 evid5ce ( decrease af=d$ by ! ro5tg5ogram is n suffici5tly exact 9 mo/ cases to af=d gr\nd = s important a conclusion z t at pres5t 9 "q4 ,n only mu/ !re be unque/ionable evid5ce1 h[ev]1 ( ! dim9ution 9 size ( ! tumor1 b ?is dim9ution mu/ be ( a k9d n ord9>ily attributable to ! natural evolution ( ! tumor4444 ,x is safe to say t multiple tumors (f] enorm\s difficulties 9 ! matt] ( int]pret+ !rapeutic results4 ,at pres5t we h 9 ! w>ds ( ! hospital a pati5t ) multiple meta/atic c>c9omas ( ! sk94 ,= sev]al mon?s we h at int]vals made accurate measurem5ts ( c]ta9 ( ^! tumors & h f\nd t "s h und]gone retrogression1 o!rs h entirely disappe>$1 :ile /ill o!rs h cont9u$ to gr[ /eadily4 ,9 ! case :i* af=d$ ! ascitic fluid us$ 9 ,hod5pyl's exp]im5ts1 _m ( ! lymphatic meta/ases und]w5t complete retrogression1 :ile ! meta/atic process 9 ! liv]1 z 0 demon/rat$ at necropsy1 increas$ progressively1 & ultimately almo/ de/roy$ t organ4 ,?us1 9 multiple c>c9osis1 ! retrogression ( individual nodules is no indication t !rapeutic int]v5tion has produc$ an improvem5t4 ,i %all n delay to emphasize ^? v>iations 9 ! size ( solid tumors :i* accompany hemorrhage & its absorption1 edemat\s swell+1 necrosis 9 ! dep?s1 & o!r famili> factors :i* cl9ically simulate1 or induce1 ! s(t5+ & ! r$uction t are s (t5 attribut$ to !rapeutic int]f]5ce4 ,b x is important to draw att5tion to a simil> feature 9 t type ( sup]ficial epi!lioma kn[n z rod5t ulc]4 ,^! new gr[?s n infrequ5tly advance at "o po9t ( ! p]iph]y1 :ile !y rec$e at ano!r1 & ?us cicatrization & contracture may simulate a p>tial recov]y4 ,?is effect is due 9 "p to alt]ations n 9 ! gr[? itself1 b 9 ! accompany+ ulc]ative process4 ,! secretions f ! gr[?s1 especially if conf9$ "u dress+s1 may h erod$ & de/roy$ ! surr\nd+ sk91 & x is tempt+ to int]pret a recession ( ! associat$ ulc]ative disease z an indication ( a favorable effect on ! new gr[?4 ,x is unque/ionably ?is aspect ( rod5t ulc]s :i* plays s g5]\sly into ! h&s ( ! num]\s v5d]s ( no/rums = ?is disease4 ,9 brief1 ! demon/rable r$uction 9 size ( a tumor1 ( a k9d n to be attribut$ to ! natural processes ( evolution ( t tumor or ( its associat$ lesions1 is ! "o ess5tial feature ( effective !rapeutic int]v5tion4 ,:5 ! v>i\s me?ods ( treatm5t :i* h be5 discuss$ 9 ?is pap] are judg$ by ! /&>d advocat$ above1 x is app>5t t none ( !m c lay claim to !rapeutic effectiv5ess4 ,! modifications ( ! disease attribut$ to !m are modifications :i* occur spontane\sly 9 a v l>ge proportion ( cases z a result ( ! natural evolution ( ! disease process4 ,?is is a fact :i* _c be too /rongly emphasiz$4 ,ow+ un=tunately to ! hopeless "* ( canc]1 m5 are n prone to /udy ) c>e all ! less] *anges :i* ! disease & ! pati5t pres5t "u ord9>y conditions2 b :5 a 8cure0 is "u inve/igation1 ! pati5t & 8 m$ical att5dant note e app>5t improvem5t ) pa9/ak+ att5tion & en?usiasm4 ,z a result1 "s evid5ce ( improvem5t 9 treatm5t is ent]$ on ! books4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,april #ag1 #aiae47 ,,! ,,direct ,,sales ,,company ,dur+ ! pa/ f\r or five ye>s1 ,! ,j\rnal has _h inquiries simil> 9 effect to ?is1 j receiv$ f ,dr4 ,e4 ,p4 ,jewett ( ,g>dn]1 ,mass43 8,w y k9dly in=m me reg>d+ a drug manufactur+ company by ! "n ( ! ,direct ,sales ,company1 ,buffalo1 ,new ,york8 ,are _! products /&>d & reliable s f> z y "k80 ,! ,direct ,sales ,company1 ,inc41 ,buffalo1 has1 accord+ to its lett]head1 ! foll[+ (fic]s3 ,geo4 ,j4 ,dott]wei*1 ,presid5t & ,treasur]1 ,c4 ,k4 ,dott]wei*1 ,vice-,presid5t1 ,l\is ,b4 ,seuf]t1 ,secret>y4 ,?is conc]n circul>izes physicians & emphasizes t x sells 8,only by ,mail40 ,x also features a 8pr(it %>+ rebate0 s*eme1 :]eby pur*as]s receive a c\pon repres5t+ #aj p] c5t4 ( ! invoice value ( ea* pur*ase4 ,aft] #ajj wor? ( m]*&ise has be5 pur*as$ ! #aj wor? ( c\pons :5 8pres5t$ = r$emption at "o "t0 w be 8honor$ z ca%0--presumably on ! pur*ase ( additional goods4 ,! ,direct ,sales ,company catalogues h = "s ye>s1 c>ri$ a gu>anty1 :i* reads1 9 "p3 8,we absolutely gu>antee all prep>ations to be 9 exact accordance ) ! ,national ,pure ,food & ,drugs ,act1 ,june #cj1 #aijf4 8,we also absolutely gu>antee all prep>ations be>+ our label to be equal1 if n sup]ior1 to any on ! m>ket40 ,9 "o ( ! ,qu>t]ly ,bullet9s ( ! ,/ate ,bo>d ( ,heal? ( ,new ,hamp%ire1 issu$ la/ ye>1 ?is p>agraph appe>$3 8,! ,direct ,sales ,company1 ,inc41 ,buffalo1 ,n4,y41 is a ph>maceutical conc]n :i* until rec5tly has done bus9ess direct ) ,new ,hamp%ire physicians4 ,9 two or ?ree in/ances compla9ts h be5 receiv$ by ?is dep>tm5t t ! prep>ations sold seem$ to be lack+ 9 pot5cy4 ,"s "t ago a physician s5t u a specim5 ( code9 sulphate tablets1 "o-f\r? gra91 conc]n+ :i* he 0 suspici\s1 admission be+ made t ! price paid 0 v mu* less ?an curr5t quotations4 ,! am\nt ( code9 sulphate actually f\nd p] tablet prov$ to be b "o-sixte5? gra94 ,lat] on1 hav+ subsequ5tly receiv$ a new lot f ?is s\rce1 ! same physician s5t u a second sample1 ! composition ( :i* 0 f\nd to be practically id5tical ) ! fir/4 ,act+ "u ! f$]al law1 #ejj lot packages ( ! foll[+ prep>ations 7 next pur*as$ ( ! company direct1 ! analytical results indicat+ s]i\s defici5cy 9 e case1 z foll[s3 8,tablets salicylic acid1 #e gra9s 444 #a4gb gra9s f\nd4 8,tablets acetylsalicylic acid1 #e gra9s 444 #b4ca gra9s f\nd4 8,tablets acetanilid1 #c gra9s 444 #a4hh gra9s f\nd4 8,tablets code9 sulphate1 #a_/d gra9 444 #a_/ae gra9 f\nd4 8,tablets nux & peps9 ,no4 #b1 claim+ peps9 #a gra91 extract nux vomica1 #a_/aj gra91 f\nd to h a gross av]age weight p] tablet ( only #a4ag gra9s1 #j4ed gra9s ( :i* 0 repres5t$ by sug> & o!r m$ic9ally in]t mat]ial4 8,tablets ,infant's ,anodyne 7,waugh7 %[$ s]i\s discrepancy f =mula40 ,! ,bullet9 add$ ! /atem5t t1 z ! company c\ld n be rea*$ "u ! ,new ,hamp%ire laws1 ! f$]al au?orities 7 appeal$ to4 ,! result ( ?is appeal appe>$ 9 ,*emical ,supplem5t #ed1 issu$ ,aug4 #ba1 #aiah1 by ! ,bureau ( ,*emi/ry ( ! ,u4 ,s4 ,dep>tm5t ( ,agriculture4 ,?is gov]nm5t bullet9 conta9$ ,notice ( ,judgm5t ,no4 #faic1 :i* describes cases ( adult]ation & misbr&+ ( "s ( ! drugs put out by ! ,direct ,sales ,company4 ,briefly1 x may be said t "s #b gra9 acetanilid tablets sold by ?is conc]n 7 f\nd by ! gov]nm5t *emi/s to conta91 r\ghly1 ab\t #a-b_/c 7#a4fa7 gra9s2 "s #a_/d gra9 calomel tablets 7 f\nd to conta9 only ab\t #a_/f 7#j4afc7 gra92 "s #a gra9 qu99 sulphate tablets 7 f\nd to h only ab\t #b_/c 7#j4fc7 gra92 "s #b-a_/b gra9 salol tablets conta9$ only ab\t #a-a_/c 7#a4ci7 gra92 "s #e gra9 sodium salicylate tablets conta9$ less ?an half t am\nt 7#b4cb gra974 ,9 addition1 ! f$]al *emi/s f\nd t "s ,elixir ( ,iron pyrophosphate ,qu99 & ,/ry*n9 7,elix4 ,f]r4 ,pyrophos4 ,qu94 et ,/ry*4 ,n4 ,f47 fell consid]ably bel[ ! /&>d ( /r5g? laid d[n by ! ,national ,=mul>y by hav+ less ?an "o-eigh? ! am\nt ( qu99 sulphate :i* ! (ficial /&>d calls =1 & only ab\t "o-fif? ! am\nt ( sug>1 sac*>9e1 :i* is n a normal +r$i5t ( ! (ficial prep>ation1 hav+ be5 sub/itut$ = "p ( ! sug>4 ,! *emi/s f\nd1 too1 t "s hydriodic acid sold by ! same conc]n1 in/ead ( conta9+1 z ! label decl>$ & z ! ,unit$ ,/ates ,ph>macopeia requires1 #a p] c5t4 ( absolute hydriodic acid1 conta9$ less ?an "o half ( #a p] c5t4 ,! ,direct ,sales ,company plead$ guilty 9 ?is case & 0 f9$ #gjj4--7;,f ,! ,j\rnal ,a4 ,m4 ,a41 ,sept4 #bg1 #aiai47 ,,discov]ies ,,& ,,discov]]s ,9 spite ( ! wond]ful a*ievem5ts ( mod]n sci5ce1 x seems impossible to get ! public to ?9k 9 sci5tific t]ms4 ,?is is d\btless due to a fundam5tal weakness 9 our educational sy/em4 ,! t5d5cy /ill is to ?9k 9 t]ms ( ! eighte5? c5tury r ?an ( ! tw5tie?4 ,_m times ,! ,j\rnal has be5 *id$1 ev5 by its fri5ds1 = fail+ to take s]i\sly prepo/]\s claims made = alleg$ discov]ies 9 m$ic9e by well-mean+ b self-delud$ en?usia/s or by %rewd & consci5celess *>latans4 ,f> too (t5 ! attitude is t any alleg$ discov]y 9 m$ic9e1 no matt] h[ biz>re or h[ humanly improbable1 %\ld be tak5 up 9 all s]i\sness & subject$ to ! te/s ( mod]n laboratory me?ods4 ,x 0 only a few ye>s ago t a quack ( unsavory antec$5ts br\ght =? an alleg$ cure = consumption--a disease t = ye>s has be5 ! subject ( /udy by ! be/ bra9s 9 ! _w--& a m$ical college sp5t ?\s&s ( doll>s 8inve/igat+0 ! 8cure10 !reby giv+ x a /&+ t x w\ld nev] h receiv$ o!rwise & incid5tally obta9+ = ! s*ool an am\nt ( publicity t may or may n h be5 desir$4 ,z ,! ,j\rnal said at ! "t1 x w\ld h be5 j z p]t95t = a body ( a/ronom]s to det]m9e by sci5tific me?ods :e!r or n ! moon is really made ( gre5 *eese4 ,! po9t we w\ld make is t ! /rides made by mod]n sci5ce h practically elim9at$ ! possibility ( m5 )\t tra9+ or special k evolv+ any epo*-mak+ discov]y4 ,9 ?is connection an editorial 9 ! ,sci5tific ,am]ican ( rec5t date1 deal+ ) ! me*anical sci5ces r ?an ! m$ical1 is well wor? quot+ 9 "p4 ,! editorial discuss$ ! 8,g>ab$0 incid5t4 8,g>ab$10 z ,our read]s "k1 0 a "n giv5 to a device :i* "o ,g>ab$ ,t4 ,k4 ,giragossian claim$ to h develop$ & :i*1 s f> z c\ld be le>n$ f ! g5]alities 9 :i* ,mr4 ,giragossian indulg$1 w\ld take en]gy out ( ! cosmos & transf] x directly into me*anical motion4 ,mr4 ,giragossian w\ld give no details reg>d+ 8 8eng9e10 b 0 s able to hypnotize ,congress into a belief t he _h some?+ wor? look+ into t x pass$ a jo9t resolution call+ = ! appo9tm5t ( five sci5ti/s to pass on ! claims = ,g>ab$4 ,! inve/igation prov$1 z might h be5 expect$1 t ! ?+ 0 uns\nd 9 pr9ciple & nonop]ative z a device4 ,! me?ods by :i* ,g>ab$ 0 br\ght be=e ! public savor$ /rongly ( ^? us$ by quacks 9 ! m$ical _w1 ! "o diff]5ce be+ t ,giragossian 0 app>5tly p]fectly s9c]e & unequivocally hone/4 ,! po9t t we br+ out1 h[ev]1 & :i*1 z we h said be=e1 0 s well express$ by ! ,sci5tific ,am]ican1 is ! utt] futility ( wa/+ ! "t ( sci5tific m5 on alleg$ inv5tions or discov]ies by m5 )\t tra9+ :o sub/itute secrecy & glitt]+ g5]alities = facts & accompli%m5ts4 ,quot+ ! ,sci5tific ,am]ican3 ,sci5tific discov]y1 once an op5 field = all com]s1 is today becom+ m & m a matt] call+ = ! mo/ int5sive special qualifications4 ,z ! body ( human k broad5s & deep5s1 x becomes increas+ly difficult to make any mat]ial addition to x4 ,any "o und]tak+ su* a task mu/ ( necessity br+ to x a long & c>eful tra9+1 acquir$ ei!r 9 ! ref9$ atmosph]e ( ! laboratory1 or 9 ! r\gh] s*ool ( close contact ) ! op]ation ( app>atus con/ruct$ by ^? :o h already qualifi$4 ,9 p>ticul>1 he mu/ possess a c>efully develop$ p[] ( mak+ accurate obs]vations & draw+ correct conclusions4 ,x is r ! habit to po9t to m5 l ,edison & ,maxim 9 refutation ( ^! necessities2 b !y are n to be s refut$4 ,^! m5 are examples1 rais$ to ! n? p[]1 ( ! great inv5tor :o has qualifi$ 9 ! ,univ]sity ( ,h>d ,knocks & ,long ,exp]i5ce4 ,on ^! gr\nds1 :5 a man comes be=e u 9 ! self-assign$ rle ( a great inv5tor1 x is incumb5t ^u him to answ]1 n necess>ily ! bald "q 8,:o are y80 b c]ta9ly ! m se>*+ "o1 8,:at are y\r qualifications to und]take ?is "w80 ,only by 8 answ] c we decide :e!r he possesses a compet5ce des]v+ ( att5tion1 or is b a dilettante play+ ) fire4 ,yet ?is obligation 0 "o :i* ,mr4 ,giragossian1 f> f meet+1 did n ev5 appe> to compreh5d4 ,to e ef=t to asc]ta9 8 qualifications he repli$ 9 ! same t]ms1 t he 0 an hone/ man1 & c\ld prove x by lett]s f 8 te*nically nondescript collection ( fri5ds & sponsors4 ,! v fact t m ?an p]sonal integrity is necess>y 9 a man :o w\ld unravel ! secrets ( ! creation ( en]gy appe>s to h escap$ 8 compreh5sion4 ,! fundam5tals ?us /at$ apply ) equal =ce to ! sph]e ( m$ical discov]y4 ,at ! "t :5 m$ic9e 0 pure empiricism x 0 n only possible b also probable t ! m$ic9al value ( c]ta9 products or comb9ations ( products might be /umbl$ on by ^? untra9$ & unskill$4 ,t "t has pass$4 ,today1 :ile x is n impossible1 x is s improbable t !re is no ju/ification 9 tak+ up ! "t ( sci5tific m5 9 inve/igat+ alleg$ discov]ies by m5 :o are utt]ly lack+ 9 ! fundam5tal qualifications ne$$ = ! /udy ( ! complex problems ( human pa?ology4--7,editorial f ,! ,j\rnal ,a4 ,m4 ,a41 ,aug4 #aj1 #aiah47 8,,drug ,,re=m0 ,z ,x ,appe>s to ! ,clevel& ,m$ical ,j\rnal ,! matt] :i* foll[s appe>$ orig9ally z an editorial 9 ! ,clevel& ,m$ical ,j\rnal1 ,novemb]1 #aiae4 ,x expresses1 we believe1 ! attitude ( ! ?9k+ physician t[>d ! subject discuss$3 ,physicians h come to ! realization t drugs are z a two-edg$ sword--"u prop] conditions1 /rik+ aga9/ ! disease2 o!rwise1 aga9/ ! pati5t's heal?4 ,! fir/ condition = _! prop] use is adequate k ( _! composition & purity2 ( _! actions & malefactions2 _! field & limitations4 ,sl[ly & pa9/ak+ly--sometimes pa9fully--?is sci5tific k has be5 ga!r$1 is /ill be+ ga!r$1 by *emi/s & ph>maci/s1 ph>macologi/s & cl9icians1 ) increas+ ?or\ghness1 c>e & discrim9ation4 ,:]e wisdom fe>s to v5ture1 unwisdom & cupidity f9d ample room4 ,! wise physician kn[s t !re are ills t drugs _c cure2 t drugs g5]ally only aid or relieve2 & t to obta9 ev5 ?is aid effici5tly & safely1 ! exi/+ sci5tific k is none too great4 ,n s ! unwise4 ,he :o sees 9 disease only a "n1 to him a "n is a suffici5t cure4 ,let !re be a mixture ) a conv5i5t & sugge/ive "n & a pleasant ta/e1 a comp5di\s index ( diseases & symptoms--& a lively imag9ation--& ! cure is accompli%$4 ,few ?+s c\ld be easi]1 & few m false4 ,x is n surpris+ t ! 8man on ! /reet0 %\ld fall into ^! errors2 x is sad t any physician %\ld be misl$ by ! sophi/ry ( int]e/$ drug v5dors4 ,physicians h ! moral obligation to in/ruct ! public 9 matt]s ( heal?4 ,prea*+ be=e practice is ( little avail4 ,x behooves ! m$ical pr(ession to make at lea/ a reasonable ef=t to clean its own h\se be=e x passes ! broom to ! public4 ,realiz+ ?is responsibility1 ! ,am]ican ,m$ical ,association "s ye>s ago e/abli%$ its ,c\ncil on ,ph>macy & ,*emi/ry4 ,?is ,c\ncil is /rictly an educational ag5cy--x collects & dissem9ates k ab\t drugs1 especially ^? drugs t are adv]tis$ to physicians & t are n describ$ 9 ! legal ph>macopeias4 ,physicians are ?us put 9 a position to discrim9ate4 ,_m h done s2 o!rs w1 a few may nev] see ! light on ?is e>?4 ,j\rnals c no long] claim t !y mislead _! read]s 9 good fai?4 ,"s--! ,clevel& ,m$ical ,j\rnal among ! fir/--h frankly ackn[l$g$ _! obligations1 & sacrific$ a lucrative income f adv]tisem5ts2 o!rs are /ill occupi$ 9 comp\nd+ ! matt] ) _! consci5ce4 ,manufactur]s are 9 a simil> position4 ,^? :o are on ! side ( sci5tific progress--or to put x mat]ially1 ^? :o realize t hone/y is ! be/ policy--are tak+ ! opportunity to sep>ate !mselves f ! di%one/ & ignorant4 ,altoge!r1 ! m$ical pr(ession may safely advise ! public on ! subject ( drugs )\t lay+ itself op5 to ! *>ge t x prea*es :at x is unwill+ to practice4 ,meantime1 ! public itself has _h a some:at simil> awak5+4 ,! progress ( ! pr(ession has necess>ily spread m or less to ! laym54 ,all sorts ( educational ag5cies h be5 work+ to conv9ce ! public t individual & national heal? is too preci\s an asset to be entru/$ to any quack :o may spell 8 praise 9 pr9t]'s ink4 ,legislators h pass$ food1 drug1 & ant9>cotic laws :i* h ar\s$ int]e/ & discussion4 ,ev5 ! 8drugless cults0 h some:at (fset _! h>m by caus+ ! public to reflect t drugg+ is n a panacea = all ills4 ,all ?is has n be5 )\t effect4 ,! public is 9 a receptive mood2 x is n conv9c$1 b wi%es to le>n4 ,legislators are prep>$ to foll[ public op9ion4 ,! purveyors ( pat5t m$ic9es are wat*+ ev5ts4 ,:at1 "u ^! conditions1 %\ld be ! attitude ( ! m$ical pr(ession8 ,pla9ly1 x %\ld cont9ue to be :at x always has be53 to /& aggressively = ! protection ( ! public heal?1 )\t any compromise4 ,9 do+ s1 x is true1 physicians w expose !mselves to ! imputation ( selfi% motives4 ,selfi%ly comm]cial m9ds _c or w n und]/& ! unselfi% ideals ( a pr(ession--t is _! loss4 ,physicians1 h[ev]1 mu/ be c>eful n to give a semblance ( reason to ! *>ge2 = t w\ld dim9i% ! effect ( _! attitude4 ,!y mu/ conf9e !mselves to in=m+ ! public ( ! facts2 & to gu>d+ ! heal? ( ! public at l>ge1 & ( _! own pati5ts 9 p>ticul>4 ,no "o1 9 a free c\ntry1 c =ce a diseas$ individual to seek effective treatm5t or prev5t him f us+ an ineffective treatm5t1 unless 8 disease imp]ils ! heal? ( o!rs4 ,at t po9t1 & n be=e1 ! gov]nm5t c & %\ld take p]sonal measures4 ,h[ev]1 x is a well recogniz$ function ( ! gov]nm5t to protect individuals aga9/ _! own ignorance4 ,x does ?is :5 x =ces ! *ild to g to s*ool2 x does ?is :5 x places ! sw9dl] 9 jail4 ,on exactly ! same pr9ciple1 ! gov]nm5t has ! "r & ! duty to protect ! un9=m$ public aga9/ ! flagrant evil ( ! pat5t m$ic9e traffic--& ! pat5t m$ic9e traffic z n[ c>ri$ on is a flagrant evil & s]ies ( evils4 ,! gov]nm5t %\ld protect ! public aga9/ adv]tisem5ts t are fram$ to sugge/ or create imag9>y ailm5ts1 ) _! att5dant mis]ies2 x %\ld protect ! public aga9/ be+ delud$ by false promises ( cure2 aga9/ ! speci\s relief t m]ely hides ! disease & bl9ds ! pati5t to its dang]s2 aga9/ drugs t may & d "w positive h>m2 aga9/ ! veil ( my/]y t makes ^! abuses possible4 ,! individual layman _c protect himself aga9/ ^! dang]s1 & has a "r to expect t ! gov]nm5t w prohibit ! indiscrim9ate sale ( any m$ic9e t may be h>mful to him4 ,he has a "r to expect1 :5 ! gov]nm5t p]mits ! sale ( a pat5t m$ic9e1 t ! m$ic9e w d him no h>m2 j z he has a "r to expect t any physician :om ! gov]nm5t p]mits to practice1 %\ld be compet5t4 ,^! are "s ( ! reasons :y physicians oppose pat5t m$ic9es z !y are n[ exploit$2 & = ^! reasons1 physicians %\ld take an absolutely uncompromis+ attitude1 & use e opportunity to educate ! public4 ,! pat5t m$ic9e int]e/s naturally try to obscure ! issue4 ,by ! art 9 :i* !y are s skilful1 !y aim to sugge/ to ! public t physicians are oppos$ to pat5t m$ic9es1 9 ord] to drive pati5ts to _! (fices4 ,!y 8=get0 to m5tion t physicians h nev] conduct$ a 8campaign0 aga9/ really effici5t prev5tive public-heal? measures1 no matt] h[ _m prospective pati5ts 7 involv$4 ,no physician has ev] refus$ to give diph!ria antitox9 because ?is w\ld dim9i% ! numb] ( 8 visits4 ,a %ort memory is a v conv5i5t asset = self-int]e/$ p]sons4 ,x is n s conv5i5t = ! public--b x is all too frequ5t4 ,physicians mu/1 !re=e1 make x pla9 t _! /& is n aga9/ pat5t m$ic9es1 b = ! protection ( ! heal? ( ! public4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,m>* #d1 #aiaf47 ,,drug ,,!rapy3 ,,! ,,fallibility ,,( ,,textbooks ,until v rec5tly1 we 7 compell$ to ackn[l$ge t little1 if any1 progress 0 be+ made 9 int]nal m$ic9e s f> z drug !rapy 0 conc]n$4 ,ev]ybody kn[s ( ! progress made 9 o!r bran*es--9 bact]iology1 9 pa?ology1 9 biologic *emi/ry1 9 surg]y1 9 etiology & 9 application ( te*nical me?ods to diagnosis4 ,rec5tly1 h[ev]1 ph>macologic rese>* & ! application ( sci5tific me?ods 9 ! /udy ( ! physiologic action ( drugs are result+ 9 def9ite1 positive progress4 ,an important lesson1 incid5tally le>n$ ?r\gh ?is sci5tific inve/igation1 is ! fallibility ( ! drug !rapy describ$ 9 textbooks4 ,! explanation is1 ( c\rse1 t _m ( ^! textbooks are m]e compilations conta9+ false /atem5ts1 unprov$ !ories1 & unv]ifi$ cl9ical evid5ce repres5t+ ! guesswork ( anci5t uncritical obs]v]s4 ,_m drugs h be51 & /ill are1 vaunt$ 9 textbooks z valuable 9 a v>iety ( conditions1 :]eas sci5tific inve/igation & controll$ cl9ical obs]vation h prov$ !m to be totally wor?less2 o!rs are prov+ to be ( value 9 an extremely limit$ numb] ( conditions4 ,! soon] writ]s ( textbooks realize ?is fact & ent] into ! _s ( ! new era1 ! bett] = ! public & = sci5tific m$ic9e4--7,editorial f ,! ,j\rnal ,a4 ,m4 ,a41 ,may #bg1 #aiaf47 ,,?omas ,,web/] ,,edg> ,tir$ ,rabbits = ,diabetes2 ,r+-,tail$ ,monkeys = ,sex ,/imulation ,dur+ ! la/ two or ?ree ye>s ,! ,j\rnal has receiv$ inquiries reg>d+ "o ,?omas ,web/] ,edg>1 ,m4,d41 ( ,new ,york ,city1 fir/1 relative to 8 alleg$ treatm5t = diabetes & m rec5tly ab\t 8 8monkey gl&0 treatm5t = sex /imulation4 ,"h is "o f a physician 9 ,wa%+ton3 8,h y any k ( ! efficacy ( a s]um made f ! pancreas ( rabbits = ! relief or cure ( diabetes8 ,x is made by ,dr4 ,t4 ,w4 ,edg> ( #gff ,we/ ,end ,ave41 ,new ,york ,city40 ,& ?is f a layman 9 ,p5nsylvania3 8,la/ ye> !re 0 publi%$ 9 ! ,new ,york ,h]ald an acc\nt ( ! new treatm5t = diabetes 9 :i* a s]um 0 inject$ 9 ! ve9s & z a result x 0 claim$ t ov] sixty-five p] c5t4 ( ! treatm5ts made 7 successful4 ,! acc\nt fur!r /at$ t !y propos$ to e/abli% "s sort ( a sanit>ium 9 ,new ,york ,city us$ especially = ! treatm5t4 ,! writ] hav+ mislaid ! acc\nt1 wrote ! ,new ,york ,h]ald z to ! doctor :o _h *>ge ( x & 9 return 0 giv5 ! "n & address4 ,dr4 ,edg> 9 a lett] "u date ( la/ ye> /at$ t ! co/ ( ! treatm5t 0 #cjj4jj1 payable beg9n+ ( ! treatm5t1 & he gave v little in=mation z to ! success ( x1 ) ! exception t if ! treatm5t did n give ! desir$ effect aft] ! end ( ?ree mon?s1 x w\ld be cont9u$ )\t any fur!r co/4 ,! writ] wrote & ask$ him ! names ( "o or two ( ! pati5ts :o _h be5 cur$1 because x seem$ r unusual t if ! treatm5t 7 a success1 x 0 necess>y = a pati5t to pay ! co/ ( ! treatm5t 9 advance4 ,to t lett] ,i h nev] receiv$ a reply40 ,:ile a physician f ,ill9ois writes3 8,i am enclos+ a clipp+ f a ,*icago pap] relative to ,dr4 ,?omas ,web/] ,edg> ( ,new ,york & 8 op]ation = transplant+ ! gl&s ( r+-tail$ monkey4 ,i note t he is a memb] ( ! ,new ,york ,c\nty ,m$ical ,society6 ,:at is !re to ?is8 ,i h se5 no m5tion ( ^! wond]s 9 ,! ,j\rnal40 ,?omas ,web/] ,edg> 0 born 9 #ahhi4 ,! records %[ t he 0 graduat$ 9 m$ic9e by ! ,univ]sity & ,bellevue ,hospital ,m$ical ,college 9 #aiac1 & 0 lic5s$ to practice m$ic9e 9 ! ,/ate ( ,new ,york ! same ye>4 ,9 ,m>*1 #aiai1 an article by ,t4 ,web/] ,edg> appe>$ 9 ! ,new ,york ,m$ical ,j\rnal on 8,diabetes ,mellitus40 ,9 ?is ,edg> gave a !ory ( ! cause ( diabetes mellitus & /at$ t he _h 8treat$ successfully1 tw5ty cases ( def9ite diabetes40 ,9 ! article he spoke positively ( ! successful results he _h obta9$ by ! 8intramuscul> injections ( my diabetic s]um40 ,no in=mation 0 giv5 reg>d+ ?is s]um except t he m5tion$ vaguely t x 0 8prep>$ f normal blood aft] ! animal is ex]cis$ to ! po9t ( fatigue40 ,illu/ration3 ,photographic reproduction 7r$uc$7 ( a few ( ! newspap] items t appe>$ 9 v>i\s p>ts ( ! c\ntry reg>d+ ,?omas ,web/] ,edg>'s alleg$ s]um = diabetes4 ,a few days aft] ! appe>ance ( ?is article 9 ! ,new ,york ,m$ical ,j\rnal1 newspap] articles appe>$ reg>d+ a cure = diabetes p]fect$ by 8,dr4 ,?omas ,web/] ,edg>1 #gff ,we/ ,end ,av5ue1 ,new ,york ,city40 ,accord+ to ^! reports1 ,edg> said3 8,i tri$ ! blood ( rabbits & f\nd :at ,i want$4 ,9 obta9+ ! blood ,i fir/ put ! rabbit ^u a treadmill & keep x !re until x rea*es a /age ( fatigue4 ,!n ,i draw ! blood1 & aft] heat+ x to #fj degrees c5tigrade sep>ate ! corpuscles f ! s]um4 ,:5 ! s]um has be5 treat$ aft] ! me?od ,i h discov]$1 ,i inject x imm$iately subcutane\sly4 8,i h atta9$ success 9 #fe p] c5t4 ( my cases & ,i h _h #ajj cases4 ,i d n say t ! cure is infallible1 b ,i am n[ c]ta9 t x w "w 9 mo/ cases1 p>ticul>ly :5 ! pati5t obs]ves ! rules laid d[n & und]goes fai?ful treatm5t40 ,9 ,april1 #aiai1 a physician 9 ,kansas wrote to ,edg> at ! reque/ ( a diabetic pati5t ask+ = in=mation ab\t ! 8s]um40 ,edg> repli$ t x w\ld be impossible to s5d ! physician any ( ! s]um = adm9i/ration unless ! 8pati5t is will+ to pay me = ! co/ ( same1 :i* w be approximately ! sum ( #be40 ,he /at$ fur!r t1 9 a few mon?s' "t1 he hop$ to be able to manufacture ! s]um 9 l>g] quantities :i* w\ld 8m ?an cut ! exp5se 9 half40 ,9 ! same mon? a layman 9 ,*icago :o read ! newspap] /ory wrote to ,edg> & ask$ = details reg>d+ t]ms & ! arrangem5ts t w\ld h to be made to take ! 8treatm5t40 ,edg> repli$ t he expect$ to be 9 ,*icago 9 a few weeks' "t & w\ld see ! man 9 consultation ) 8 regul> physician1 t he w\ld adm9i/] ! fir/ injection & give in/ructions to ! physician z to subsequ5t injections4 ,edg> add$3 8,my cu/om is to h all fees paid 9 advance & my *>ge is #bjj4jj by c]tifi$ *eque or money-ord]40 ,a layman 9 "o ( ! small] cities ( ,new ,york wrote to ,edg> 9 ,may1 #aiai1 & receiv$ a reply f ,edg>'s secret>y /at+ t ! treatm5t ext5ds 8ov] a p]iod ( ?ree mon?s1 co/ #aej40 ,he 0 also told t ! s]um c\ld be s5t to 8 physician = adm9i/ration 8= ! sum ( #be prepaid by money-ord]40 ,! lett] clos$ ) ! /atem5t t ,edg> 8has be5 v successful ) ! s]um40 ,illu/ration3 ,photographic reproduction 7greatly r$uc$7 ( small portion ( ! publicity t has be5 giv5 to ,edg> relative to 8 op]ation = 8sex /imulation0 by ! transplantation ( ! gl&s ( r+-tail$ monkeys6 ,a layman 9 ,s\? ,c>ol9a :o wrote to ,edg> 9 ,june1 #aiai1 0 told t ! treatm5t z adm9i/]$ by ,edg> 8ext5ds ov] a p]iod ( two mon?s2 fee #cjj0 & t if he want$ ! s]um adm9i/]$ by 8 own physician ! co/ w\ld be 8#ej prepaid40 ,9 ,may1 #aibj1 ,edg> _h ano!r article on diabetes1 also 9 ! ,new ,york ,m$ical ,j\rnal4 ,9 ?is1 too1 he ref]s to 8 s]um 9 ! foll[+ words3 8,9 conclusion ,i may /ate t ,i h be5 able to produce "s r />tl+ results by ! use ( my s]um1 :i* is prep>$ f ! blood ( rabbits aft] !y h und]gone a s]ies ( maneuvres capable ( activat+ ! v>i\s int]nal secretory gl&s to increas$ action4 ,! s]um conta9s ! int]nal secretions 9 hormone =m40 ,gradually ! newspap] publicity on ,edg>'s diabetic 8s]um0 di$ d[n4 ,!n1 9 ,novemb]1 #aibj1 !re appe>$--aga9 9 ! ,new ,york ,m$ical ,j\rnal--an article by ,edg> on 8,/]ility1 ,sex ,/imulation & ,endocr9es40 ,edg> !re /at$ t he wi%$ to place himself 8on record z be+ int]e/$ 9 sex /imulation0 & t he want$ to notify ! pr(ession t he _h ano!r s]um :i* he 0 us+ 8) success 9 ! treatm5t ( ?is condition40 ,?us3 8444 ,i feel entitl$ to /ate t ,i h a di/9ctly b5eficial s]um = ! alleviation ( pres5ile & s5ile defici5cy2 & t my product is capable ( produc+ a new lease ( life 9 ^? ^: functions h be5 r$uc$ to a m9imum40 ,h[ long ,edg> has be5 featur+ 8 8s]um0 = 8sex /imulation0 x is difficult to det]m9e1 b dur+ ! la/ ye> ! newspap]s h c>ri$ sporadic reports ( alleg$ rem>kable results produc$ by 8,dr4 ,?omas ,web/] ,edg> ( #gff ,we/ ,end ,ave41 ,new ,york10 ?r\gh ! transplantation ( ! 8int]/itial gl&0 tak5 f 8a special species ( orang\tang40 ,a layman :o wrote ,edg> "s mon?s ago reg>d+ ?is 8gl& implantation0 receiv$ a lett] f ,edg>'s secret>y /at+ t ! treatm5t 8has be5 mo/ successful 9 all cases0 & assur+ him t 8! exp]im5tal /age _h be5 pass$1 & ! op]ation is advis$ 9 all cases pres5t+ symptoms ( pres5ility or age40 ,a week lat] ! same man receiv$ a lett] writt5 by ,edg> himself 9 :i* he reit]at$ ! claim t all ( ! op]ations _h be5 successful4 ,edg> add$ t he 0 n[ treat+ all cases 8by op]ation in/ead ( ! s]um10 & t 8! fee = op]ation is #ejj1 inclusive ( ! sanit>ium10 ! pati5ts rema9+ 9 ! 8sanit>ium0 8= f two to ?ree days40 ,a mon? or two lat] ! prospective pati5t receiv$ ano!r lett] sign$1 8,?omas ,web/] ,edg>1 ,m4,d410 assur+ him t 8! effect is p]man5t1 & does n we> (f4 ,no ill effects c possibly result40 ,comm5c+1 ,oct4 #a1 #aiba1 a s]ies ( s5sational articles appe>$ reg>d+ "o ( ,edg>'s alleg$ monkey gl& implantations p]=m$ on an individual describ$ z 8"o "t lawy] & !n a writ]40 ,^! articles purport to be writt5 p>tly by "o ( ! newspap] /aff1 p>tly by ! man und]go+ ! 8op]ation0 & at lea/ "o by ,?omas ,web/] ,edg>4 ,! mat]ial is play$ up 9 ! /yle typical ( yell[ j\rnalism4 ,9 addition to repeat$ pictures ( ! individual :o is be+ op]at$ on1 !re also are giv5 pictures ( ,?omas ,web/] ,edg> & "o ( 8 8r+-tail$ monkeys40 ,d\btless ! 8/ory0 has sold _m newspap]s4 ,its s5sational "*1 ! elem5t ( my/]y & above all its sex slant w appeal to t l>ge class ( newspap] read]s t hung] = /uff ( ?is sort4 ,d\btless1 too1 x has prov$ a l>ge adv]tis+ asset = ,?omas ,web/] ,edg>4 ,! /atem5t t appe>s 9 ! s]ies to ! effect t ,edg> 8is a memb] ( ! ,c\nty ,m$ical ,society ( ,new ,york0 is incorrect4 ,edg> is n a memb]4 ,! fur!r newspap] claim t ,edg> is 8an au?ority on gl&ul> transplantation0 %\ld also be accept$ ) res]vations4 8,au?orities0 are creat$ ) ease 9 ! pages ( newspap]s4 ,edg> may possibly be t]m$ an au?ority 9 a newspap] or1 %all we say1 ,pickwickian s5se4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,oct4 #ae1 #aiba47 ,! ,j\rnal ,receives a ,lett] ,d5\nc+ 8,m$ical ,cl]ks0 & 8,bias$ ,sceptres0 ,! ,j\rnal rec5tly publi%$ 9 ?is dep>tm5t "s inquiries reg>d+ ,?omas ,web/] ,edg>1 ,m4,d41 ( ,new ,york ,city1 relative to "s alleg$ s]ums t ,dr4 ,edg> _h develop$ = diabetes & sex /imulation1 respectively1 & relative also to ! newspap] publicity giv5 ,dr4 ,edg> 9 connection ) ! alleg$ transplantation ( gl&s f 8r+-tail$ monkeys40 ,we are 9 receipt ( a lett] sign$1 8,?omas ,web/] ,edg>1 ,m4,d410 & read+ z foll[s4 ,x is giv5 v]batim et lit]atim3 8,g5tlem53--,i h read ) great int]e/ y\r editorial reg>d+ ! publicity giv5 my "w 9 metabolism1 & gl& implantation4 8,y\r pseudo1 expose1 & di/9ctly libel\s ins9uations are unju/1 & !y lead me to believe t y are go+ to be call$ to acc\nt at a v e>ly date4 8,my pr(ession is ! practice ( m$ic9e1 & ! policy ( my practice is n controll$ by ! editorial dep>tm5t ( ! j\rnal4 ,i am progressive1 & a firm believ] t legitim5t m$ic9e & surg]y c n be practic$ if ! physician be gov]n$ by a set ( m$ical cl]ks1 :o disda9fully boa/ t !y control1 & gov]n ! heal+ art ?r\gh out ! bread? ( ! l&1 ) a sceptre t is bias$ & /eep$ 9 ! unadult]at$ comm]cialism ( a c]ta9 m$ical clique4 8,aside f ! fact t ,i am an associate editor on a m$ical publication1 x is disgraceful1 z well z unju/ t y h writt5 su* an editorial ) out fir/ inve/igat+ ! !rapeutic value ( my s]um1 & implantation op]ation4 8,! psy*ology ( y\r editorial1 only reflects on y\r editorial dep>tm5t1 & w t5d to belittle "s ( ! greate/ surgeons 9 ! c\ntry4 8,x may be to y\r advantage to "k1 t ?is v aft]noon1 ,i 0 on ! program ) ! foll[+ m54 8,dr4 ,lewis ,gregory ,cole--,new ,york 8,dr4 ,*>les ,h4 ,mayo--,ro*e/]1 ,m9n4 8,dr4 ,john ,b4 ,deav]--,philadelphia 8,dr4 ,*>les ,peck--,new ,york4 8,my pap] 0 entitl$--,s5ility1 its etiology & treatm5t by gl& implantation4 ,i am sure ! above m5tion$ g5tlem5 are ?or\ghly a%am$ ( y\r actions 9 ! matt]1 z well z ?or\ghly disgu/$ ) ! baby l attitude y h display$4 ,y h no s5se ( fair play1 & if x is ) 9 my p[] to undue ! wrong :i* y h wr\ght me1 ,i %all endeavor to v9dicate myself 9 ! eyes ( ! cle> ?9k+ memb]s ( ! pr(ession4 8,i s9c]ely tru/ y w publi% ?is communication1 9 ord] t my bre?r5 %all und]/& & appreciate t y\r ?ru/ has n gone unnotic$4 8,x is my hope t ! v>i\s m$ical societies ?r\gh out ! c\ntry1 w call ^u me to read a pap] on my "w1 s t ,i may be able to (f] sub/antial evid5ce to ! fact t y h done me an inju/ice4 8,v truly y\rs1 ,,twe_/,,ael ,sign$ 8,?omas ,web/] ,edg>1 ,m4,d40 ,dr4 ,edg>'s /atem5t t he _h be5 on ! program ) ,drs4 ,cole1 ,mayo1 ,deav] & ,peck 0 suffici5tly />tl+ to prompt fur!r inve/igation4 ,x 0 f\nd t ! program 9 "q 0 t ( ! annual meet+ ( ! ,new ,york & ,new ,engl& ,association ( ,railway ,surgeons4 ,x 0 fur!r f\nd t ,edg>'s "n did appe> on "s ( ! pr9t$ programs b n on o!rs4 ,x 0 r naturally assum$ t ! "n _h be5 put on ! program be=e ! (fic]s ( ?is organization _h se5 ! crude publicity to :i* ,! ,j\rnal rec5tly call$ att5tion4 ,x 0 f\nd1 h[ev]1 t aft] sev]al hundr$ programs _h be5 pr9t$ ab\t #aej m 7 ne$$ & 89 ! meantime1 ,dr4 ,edg> _h come into ! limelight0 9 8 r+-tail$ monkey gl& transplantation rle & 80 invit$ to read a pap] on ! subject40 ,:ile he accept$ ?is invitation ! secret>y ( ! organization tells u t ,edg> did n read 8 pap] b1 :5 ! pap] 0 call$1 decl9$1 say+ x 0 "t = him to be 9 8 (fice6 ,z = ! re/ ( ,dr4 ,edg>'s communication1 ,! ,j\rnal appreciates t c\rtesy is due 8an associate editor on a m$ical publication0--ref]r+ d\btless to ! ,we/]n ,m$ical ,times4 ,dr4 ,edg>'s pron\ncem5t t 8legitimate m$ic9e & surg]y c n be practic$ if ! physician be gov]n$ by a set ( m$ical cl]ks0 seems reasonable--if cryptic4 ,b x is :5 he *>ges t ^! 8cl]ks0 gov]n ! heal+ art 8) a sceptre t is bias$ & /eep$ 9 ! unadult]at$ comm]cialism ( a c]ta9 m$ical clique10 t he really %9es4 ,:atev] op9ion "o may hold ( ,dr4 ,edg>'s ability to comp\nd s]ums1 surely no "o c "q 8 skill z a mix] ( metaphors4 ,8 ref]5ce to 8sceptres0 des]ves to be embalm$ 9 e textbook on rhetoric ) ! classic ( ! ,hib]nian /atesman :o passionately decl>$3 8,i smell a rat6 ,i see x float+ 9 ! air6 ,b1 m>k y1 ,sir1 ,i %all nip x 9 ! bud60--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,dec4 #c1 #aiba47 ,,glyc]ophosphates ,physicians :o prescribe on def9ite pr9ciples mu/ (t5 be puzzl$ by ! numb] & v>iety ( glyc]ophosphates on ! m>ket4 ,all available evid5ce indicates t1 z s\rces ( phosphorus to ! animal organism1 ! glyc]ophosphates possess no advantages ov] ! ord9>y inorganic phosphates4#bij ,! glyc]ophosphates are split up 9 ! inte/9e1 & lib]ate inorganic phosphates4 ,9 ?is =m !y are absorb$ & utiliz$1 if !y are utiliz$ at all4 ,!re is no evid5ce t glyc]ophosphates h any ph>macologic action to w>rant ! belief t !y are ( use z !rapeutic ag5ts4 ,! !ory t organic phosphorus comp\nds are m readily assimilable ?an inorganic comp\nds & h5ce a bett] means ( introduc+ phosphorus into ! sy/em is /ill kept alive 9 ! promotion ( c]ta9 propriet>y mixtures1 9 spite ( ! sci5tific evid5ce t ! organism c assimilate phosphorus q z readily f inorganic z f organic phosphorus comp\nds4#bia ,! glyc]ophosphates w cont9ue to be manufactur$ until physicians refuse to prescribe !m4 ,a *emi/ 9 ! 8rese>* laboratory0 ( a well kn[n manufactur+ firm has rec5tly giv5 a r int]e/+ reason = ! use ( glyc]ophosphates--f ! manufactur]s' po9t ( view4 ,he is quot$ z say+3 8,on acc\nt ( ! in/ability ( phosphorus 9 elixir ( phosphorus1 nux vomica & damiana we h q rec5tly replac$ ! phosphorus by glyc]ophosphates4 ,su* a prep>ation is app>5tly equally z effective1 = we cont9ue to h a great dem& = x40 ,?is is d\btless a suffici5t reason = ! sub/itution f ! manufactur]s' po9t ( view2 b h[ ab\t ! pati5t1 :o1 aft] all1 is ! "o to be consid]$8 ,is x n a matt] ( consid]able importance to ! pati5t :e!r he receives phosphorus1 "o ( ! mo/ p[]ful drugs kn[n1 or ! in]t glyc]ophosphates8 ,! *emi/'s /atem5t seems to imply t x is n4 ,x may be ( int]e/ to recall t a memb] ( ! firm ^: *emi/ gives ?is 8reason0 = ! use ( glyc]ophosphates1 9 a rec5t address1 0 r sev]e 9 8 condemnation ( in/itutions ( le>n+1 hospitals1 etc41 = _! lack ( coop]ation ) manufactur]s3 he said t 8!y %\ld welcome an opportunity to let any manufactur] try out or te/ 8 products 9 _! cl9ics1 laboratories1 etc40 ,a te/ z to :e!r !re is a diff]5ce betwe5 ! action ( glyc]ophosphates & ord9>y poison\s yell[ phosphorus1 especially :5 ! =m] are mix$ ) extracts ( nux vomica & damiana1 w\ld n be likely to appeal to _m hospitals & laboratories z a v promis+ field ( rese>* at ?is day s9ce1 z has be5 /at$1 ! sci5tific evid5ce at pres5t available does n furni% any w>rant = ! !rapeutic use ( glyc]ophosphates4--7,editorial f ,! ,j\rnal ,a4 ,m4 ,a41 ,april #ae1 #aiaf47 #bij ,organic ,phosphorus ,comp\nds1 ,editorial1 ,j4 ,a4 ,m4 ,a4 #dj3 #aieh 7,june #ba7 #aiac4 ,m>%all1 ,e4 ,k43 ,! ,!rapeutic ,value ( ,organic ,phosphorus ,comp\nds1 ,j4 ,a4 ,m4 ,a4 #dd3 #egc 7,feb4 #ac7 #aiae4 #bia ,m>%all1 ,e4 ,k43 ,! ,!rapeutic ,value ( ,organic ,phosphorus ,comp\nds1 ,j4 ,a4 ,m4 ,a4 #dd3 #egc 7,feb4 #ac7 #aiae4 ,,influ5za ,,vacc9es ,) ! appe>ance ( ! epidemic ( influ5za1 reports began to appe>1 *iefly 9 newspap]s1 z to new s]ums1 vacc9es1 drugs & o!r me?ods = *eck+ & ev5 = cur+ ! disease4 ,a few samples ( su* z h come to ,! ,j\rnal appe> 9 our ,tonics & ,s$atives ,dep>tm5t ?is week4 ,9 ,massa*usetts1 ,commission] ,e4 ,r4 ,kelly appo9t$ two committees to inve/igate ! value ( influ5za vacc9es z a prev5tive ag5t & z a treatm5t ( ! disease4 ,! fir/ committee1 a special bo>d = sci5tific inve/igation1 consi/+ ( ,dr4 ,m4 ,j4 ,ros5au1 *airman1 & ,fr$]ick ,p4 ,gay & ,george ,w4 ,mc,coy1 0 appo9t$ to consid] ! evid5ce available on ! prophylactic & !rapeutic use ( vacc9es aga9/ influ5za4 ,?is committee pres5t$ ! foll[+ conclusions3 #a4 ,! evid5ce at h& af=ds no tru/wor?y basis = reg>d+ prophylactic vacc9ation aga9/ influ5za z ( value 9 prev5t+ ! spread ( ! disease1 or ( r$uc+ its sev]ity4 ,! evid5ce f ! pres5t epidemic1 ?\gh meag]1 sugge/s t ! incid5ce ( ! disease among ! vacc9at$ is small] ?an among ! nonvacc9at$4 ,! bo>d1 !re=e1 concludes t fur!r exp]im5tal evid5ce %\ld be collect$4 #b4 ,! evid5ce at h& conv9ces ! bo>d t ! vacc9es we h consid]$ h no specific value 9 ! treatm5t ( influ5za4 #c4 ,!re is evid5ce t no unfavorable results h foll[$ ! use ( ! vacc9es4 ,! second committee1 kn[n z ! ,special ,bo>d ( ,/ati/ical ,inve/igation1 consi/$ ( ,dr4 ,george ,c4 ,:ipple1 *airman1 ,william ,h4 ,davis & ,f4 ,c4 ,crum4 ,?is committee report$3 #a4 ,! weight ( su* /ati/ical evid5ce z we h be5 able to accumulate indicates t ! use ( ! influ5za vacc9e :i* we h inve/igat$ is )\t !rapeutic b5efit4 ,exceptional cases :]e app>5t b5efit has result$ f ! use ( ! vacc9e c be mat*$ by o!r cases :]e simil> recov]ies h be5 made )\t vacc9ation4 #b4 ,! /ati/ical evid5ce1 z f> z x goes1 indicates a probability t ! use ( ?is influ5za vacc9e has "s prophylactic value4 #c4 ,!re is also "s evid5ce to ! effect t o!r me?ods ( protection1 su* z op5-air treatm5t & ! use ( prop] masks1 are effective 9 protect+ expos$ att5dants1 & ! use ( vacc9e %\ld n be tak5 z an excuse = omitt+ su* safegu>ds4 ,z a result1 ! foll[+ recomm5dations 7 made3 ,t ! /ate enc\rage ! di/ribution ( influ5za vacc9e int5d$ = prophylactic use1 b 9 su* mann] z w secure sci5tific evid5ce ( ! possible value ( ! ag5t4 ,! use ( su* vacc9e is to be reg>d$ z exp]im5tal4 ,t ! /ate %all nei!r furni% nor endorse any vacc9e at pres5t 9 use = ! treatm5t ( influ5za4 ,^! reports are cons]vative1 & (f] to o!r heal? commission]s & _! communities a reliable guide z to proc$ures t %\ld be adopt$ be=e subject+ or try+ out on ! public any me?od ( prev5tion or treatm5t t may be (f]$4 ,^! matt]s are ! doma9 ( m$ical sci5ce1 & m$ical sci5ti/s ( recogniz$ ability %\ld be call$ on to make ! decision4--7,editorial f ,! ,j\rnal ,a4 ,m4 ,a41 ,oct4 #ai1 #aiah47 ,s]ums & ,vacc9es ,) respect to s]ums & vacc9es 9 influ5za1 !re are c]ta9 simple facts & consid]ations t physicians w d well to keep 9 m9d at ?is times4 ,! ma9 po9t to keep always 9 sight is t un=tunately we z yet h no specific s]um or o!r specific means = ! cure ( influ5za1 & no specific vacc9e or vacc9es = its prev5tion4 ,su* is ! fact1 all claims & propag&i/ /atem5ts 9 ! newspap]s & else:]e to ! contr>y not)/&+4 ,?is be+ ! case1 ef=ts at treatm5t & prev5tion by s]ums & vacc9es1 n[ hurri$ly und]tak51 are simply exp]im5ts 9 a new field1 & ! true value ( ! results _c be pr$ict$ by any "o4 ,inde$1 ! exact results c be det]m9$ if at all only aft] a "t1 9 mo/ cases probably n until ! epidemic is pa/ & all ! returns fully canvass$4 ,consequ5tly1 ! physician mu/ keep 8 head level & n all[ himself to be l$ into mak+ m promises ?an ! facts w>rant4 ,?is w>n+ applies especially to heal? (fic]s 9 _! public relations4 ,z to s]um treatm5t1 ! only notewor?y new me?od s f> is ! injection 9 sev]e cases ( influ5zal pneumonia ( ! s]um ( pati5ts :o h recov]$ f su* pneumonia4#bib ,! pr9ciple ( ?is me?od is rational2 analog\s proc$ures h giv5 seem+ly good results 9 sc>let fev] & o!r diseases2 & ! results report$ 9 influ5zal pneumonia appe> promis+4 ,fur!r trial ( ?is treatm5t "u prop] conditions consequ5tly seems to be w>rant$4 ,x %\ld be borne 9 m9d1 h[ev]1 t ,mc,guire & ,r$d5#bib made _! obs]vations 9 ! decl9+ phase ( ! epidemic :5 ! organism or organisms conc]n$ appe>$ to be los+ virul5ce4 ,= ?is & o!r reasons1 ! expectations z to :at may be accompli%$ by ?is me?od mu/ be kept )9 reasonable b\nds4 ,influ5za is a self-limit$ disease ) v>iable complications & ( v>iable sev]ity 9 diff]5t places1 ?us (f]+ great difficulties 9 ! way ( evaluation ( diff]5t me?ods ( treatm5t4 #bib ,mc,guire1 ,l4 ,w41 & ,r$d51 ,w4 ,r43 ,treatm5t ( ,influ5za ,pneumonia by ! ,use ( ,convalesc5t ,human ,s]um3 ,prelim9>y ,report1 ,j4 ,a4 ,m4 ,a4 #ga3acaa 7,oct4 #ai7 #aiah4 ,at lea/ two k9ds ( vacc9e are 9 use 9 ! hope t !y may h prev5tive effects4 ,"o consi/s solely ( kill$ influ5za bacilli2 x be+ ext5sively us$ 9 ! ,ea/4 ,we h z yet no decisive figures z to its effects1 b !re is an impression t x may h "s value4 ,! o!r vacc9e is a mix$ vacc9e ( ! m important bact]ia 9 ! respiratory tract 9 influ5za1 pr9cipally pneumonococci1 /reptococci & influ5za bacilli4 ,x appe>s t vacc9es ( ?is nature are 9 ext5sive use1 b we h no evid5ce t any b5efit w be d]iv$ f !m4 ,to say t ?\s&s h be5 vacc9at$ ) app>5tly good results means no?+ at all1 simply because we are /ill 9 ! mid/ ( ! outbreak1 9 _m places ev5 9 ! e>li] /ages4 ,h[ sl5d] ! basis ( ?is anti-influ5zal vacc9ation :5 x is consid]$ t ! real nature ( influ5za is /ill unkn[n6 ,9 any ev5t1 x w require _m c>efully elaborat$ & controll$ obs]vations be=e any?+ def9ite may be le>n$ 9 reg>d to ! effect ( ^! vacc9es1 & x is probably safe to say t no?+ on :i* to rely 9 ! future c be le>n$ f ! indiscrim9ate vacc9ation n[ go+ on4 ,!re is1 !re=e1 no basis on :i* promise ( protection f vacc9es may be made4 ,!y may be h>mless1 & !y may or may n be ( prev5tive value4--7,editorial f ,! ,j\rnal ,a4 ,m4 ,a41 ,oct4 #bf1 #aiah47 ,,intrav5\s ,,!rapy ,! intrav5\s adm9i/ration ( drugs is a new dep>ture 9 !rapy1 b "o :i* is rapidly increas+ 9 use4 ,among its reput$ advantages are t x is ! quicke/ means ( obta9+ ! effects ( a drug1 ! effects are obta9$ ) a c]ta9ty n obta9$ by o!r me?ods1 & !y are s m>k$ t !y _c fail to impress ! obs]v]4 ,^! advantages 9 _m cases are app>5t r ?an real2 b ev5 7 !y real advantages1 !y %\ld n bl9d u to ! v>i\s & s]i\s dang]s :i* ?is me?od involves4 ,! te*nic1 al?\gh n difficult1 mu/ be ?or\ghly ma/]$1 or undue pa91 infection1 air embolism1 or ev5 dea? may result4 ,su* accid5ts1 h[ev]1 are ord9>ily easily avoid$1 & %\ld be consid]$ q inexcusable4 ,m s]i\s is ! fact t ! drugs giv5 intrav5\sly rea* ! sy/em1 & especially ! he>t1 9 a diff]5t mann] & conc5tration f t to :i* physicians are accu/om$ ) ord9>y me?ods ( adm9i/ration4 ,ph>macologi/s h long practic$ intrav5\s adm9i/ration1 :5 /udy+ acute effects ( drugs1 & !y h obs]v$ t frequ5tly ! imm$iate result ( su* injections is a prompt fall ( blood pressure1 n obta9$ :5 ! same drugs are giv5 by m\? or ev5 hypod]mically4 ,?is fall 9 blood pressure is commonly attribut$ to irritation ( ! endoc>dium4 ,x is usually ( %ort duration1 b is c]ta9ly undesirable & sometimes may h s]i\s results4 ,x has also be5 obs]v$ t sev]al drugs1 = in/ance1 qu99 & potassium1 depress ! c>diac muscle :5 giv5 intrav5\sly mu* m ?an :5 giv5 9 o!r ways4 ,fur!rmore1 any sub/ance :i* t5ds to precipitate prote9s mu/ be inject$ sl[ly & ) extreme caution1 or x w produce intravascul> clott+ & sudd5 dea?4 ,dea?s h result$ n only f a lack ( k ( ! te*nic ( intrav5\s !rapy1 b also f a lack ( k ( drugs :i* may be s adm9i/]$4 ,sudd5 dea? has be5 report$ foll[+ ! injection ( an iron prep>ation conta9+ peptone1 & also foll[+ intrav5\s injection ( e!r4 ,intrav5\s injections1 :ile sometimes sup]ior to ! sl[] me?ods1 are di/9ctly inf]ior :5 a cont9u\s1 r ?an a sudd51 action is desir$4 ,drugs leave ! blood sy/em ) great rapidity1 & !re=e _! action on ! circulation w cease promptly unless !y are cont9u\sly suppli$4 ,x w\ld be undesirable to inject intrav5\sly su* drugs z iodids1 nitrites1 iron or salicylates4 ,) ^! dang]s & disadvantages 9 m9d1 x seems unwise to resort to promiscu\s intrav5\s m$ication until ! effects ( ?is me?od h be5 /udi$ 9 detail = ! drugs employ$1 & unless !re are di/9ct advantages to be secur$4 ,?is is ! case :5 an imm$iate action is necess>y 9 em]g5cies1 z 9 ! use ( /rophan?9 = c>diac collapse1 qu99 9 p]nici\s mal>ia1 etc41 or if ! drug w\ld be de/roy$ 9 ! /oma* or tissues z 9 ! case ( salv>san1 or :5 ! drug is n adequately absorb$ by any o!r *annel1 z 9 ! case ( ep9ephr94 ,intrav5\s !rapy w be mo/ securely advanc$ if its employm5t is re/rict$ to su* well def9$ fields4 ,^! fields c be satisfactorily det]m9$ only by a sci5tific ph>macologic /udy ( ! action ( ^! drugs :5 s adm9i/]$ 9 animals1 z well z 9 man1 "u conditions 9 :i* ! results are c>efully controll$4 ,! intrav5\s me?od is an impressive "o1 approa*+ 9 prep>ation almo/ to t :i* goes ) a surgical op]ation4 ,! pati5t is usually int]e/$ & impress$ by ?is new1 & to him1 my/]i\s me?od4 ,!re is a psy*ic elem5t 9 8 reaction to ! injection :i* is n a factor 9 8 reaction to ! same drug :5 giv5 by m\?4 ,! intrav5\s injection ( a complex mixture w\ld appe> to be p>ticul>ly repreh5sible4 ,little is kn[n1 z has be5 /at$1 ( ! results to be expect$ f intrav5\s !rapy1 ev5 ) simple sub/ances4 ,! use ( complex mixtures w )\t d\bt react aga9/ ! prop] use ( ! me?od4--7,editorial f ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #aa1 #aiaf47 ,,iod9 ,,fumes ,"o ( ! important factors connect$ ) !rapeutics z a sci5ce is ! me?od ( adm9i/ration ( m$ic9al sub/ances4 ,drugs may be giv5 by m\?1 by hypod]mic or intrav5\s injection1 by inhalation1 by inunction or1 less frequ5tly1 by ! use ( o!r entrances into ! body4 ,9 *oos+ a me?od1 ! physical *>act]s ( ! sub/ance to be adm9i/]$ & ! imm$iate effects ( ! sub/ance on ! body tissues ) :i* x may come 9 contact mu/ be especially tak5 into consid]ation4 ,^! factors apply p>ticul>ly 9 ! case ( sub/ances l iod91 ars5ic1 m]cury or ! biologic products 9 :i* ! mode ( adm9i/ration radically modifies ! action4 ,= "s "t1 manufactur]s h urg$ sub/itutes = t9cture ( iod91 claim+ t _! sub/itutes 7 free f ! undesirable prop]ties ( ! t9cture1 &1 at ! same "t1 possess$ special virtues :i* ! t9cture c\ld n possess4 ,m rec5tly1 att5tion has be5 direct$ to ! adm9i/ration ( iod9 9 ! =m ( vapor4 ,! diffus+ & p5etrat+ p[]s ( gases h p>ticul>ly attract$ ! att5tion ( !rapeuti/s1 s9ce by ?is me?od drugs may be appli$ to r inaccessible portions ( ! body1 su* z ! l9+ ( ! lungs1 ! ?roat & ! muc\s membranes ( ! g5ito-ur9>y tract4 ,fur!rmore1 x has be5 ass]t$ t iod9 9 ! =m ( fumes has increas$ comb9+ p[]s1 & is ?us f> m pot5t 9 effect ?an iod9 adm9i/]$ by any o!r r\te4 ,!re d n seem to h be5 any adequate sci5tific inve/igations ( ! subject1 h[ev]1 until ! rec5tly publi%$ results ( ,luckh>dt & 8 collaborators#bic at ! ,univ]sity ( ,*icago4 ,9 _! exp]im5ts1 bo? on man & on animals1 accurately det]m9$ quantities ( iod9 7 vaporiz$ 9 a special device1 & ! fumes appli$ to ! sk94 ,at ! same "t1 ! t9cture 0 appli$ to ! sk9 ( o!r p]sons z a control4 ,iod9 0 also appli$ to ! sk9 ( dogs ) hyp]pla/ic ?yroid gl&s2 & ! effects on ! gl&1 be=e & aft] adm9i/ration1 /udi$4 ,dogs 7 also us$ to det]m9e :e!r iod9 fumes 7 absorb$ f ! lungs4 ,z a result ( ^! inve/igations1 :i* are report$ 9 great detail1 x 0 f\nd t iod91 :5 deposit$ on ! sk9 9 ! =m ( fumes1 is absorb$4 ,m iod9 0 recov]$ f ! ur9e1 foll[+ ! application ( ! t9cture1 ?an 0 recov]$ foll[+ ! use ( ! fumes4 ,?is result is expla9$ by ! au?ors on ! gr\nd t probably m iod9 0 actually appli$1 & t ! iod9 s deposit$ 0 held 9 comb9ation ) ! prote9 dur+ ! process ( coagulation ( ! latt] by ! alcohol ( ! t9cture1 lead+ to a /ate ( cont9u\s absorption4 ,x is probable1 fur!rmore1 t ! iod9 deposit$ on ! sk9 9 ! =m ( fumes is revaporiz$ to "s ext5t by ! heat ( ! body4 #bic ,luckh>dt1 ,a4 ,b42 ,ko*1 ,f4 ,c42 ,s*ro$]1 ,w4 ,f42 & ,weil&1 ,a4 ,h43 ,! ,physiological ,action ( ,fumes ( ,iod91 ,j4 ,ph>macol ,exp]4 ,!rap4 #ae3 #a 7,m>*7 #aibj4 ,mo/ important 7 ! effects ( iod9 adm9i/]$ intratra*eally 9 ! =ms ( fumes4 ,iod9 giv5 9 ?is way seems to be rapidly & completely absorb$2 b x 0 f\nd t ! adm9i/ration ( ! fumes ( iod9 by inhalation ?r\gh ! respiratory passages1 ev5 9 small quantities1 is fraught ) great dang]4 ,su* adm9i/ration induces dyspnea2 & :5 x is giv5 9 l>ge quantities1 acute & fatal pulmon>y edema ensues )9 tw5ty-f\r h\rs4 ,:5 respiratory disord]s are pres5t at ! "t ( adm9i/ration1 ! fatal edema sup]v5es v quickly4 ,?us f>1 no device design$ to deliv] fumes controls ! dosage4 ,x is int]e/+ to consid]1 z d ! au?ors1 ! fact t ! fumes ( iod9 h ! same effect z ^? ( two o!r halog5s1 brom9 & *lor94 ,! results ( ^! exp]im5ts ) iod9 fumes on ! dog1 z %[n by necropsy f9d+s1 are practically id5tical ) ^? report$ by milit>y surgeons z f\nd 9 soldi]s gass$ ) *lor9 dur+ ! w>4 ,! results ( ^! rese>*es are additional evid5ce z to h[ sci5tific rese>* may confirm or d5y conclusions bas$ on empiric !rapeutic obs]vations4 ,! "w may well s]ve z a model = simil> exp]im5ts1 n[ be+ made1 on ! !rapeutic use1 intrav5\sly1 ( su* sub/ances z nonspecific prote9s or organic prep>ations ( toxic drugs4 ,! pati5t %\ld at lea/ h ! *ance t is af=d him by prelim9>y exp]im5ts1 sci5tifically p]=m$ on animals 9 ! rese>* laboratory4--7,editorial f ,! ,j\rnal ,a4,m4,a41 ,may #bi1 #aibj47 ,,italian ,,physico-,,*emical ,,company ,_m & v>i\s are ! lett]s receiv$ by ,! ,j\rnal ask+ = in=mation ab\t an alleg$ sci5tific organization 9 ,italy /yl$ l',acadmie ,physico-,*imique ,itali5ne4 ,?is ,italian ,physico-,*emical ,academy is op]at$ f ,pal]mo1 ,italy4 ,"h is ! s*eme3 ,dr4 ,john ,doe1 an ,am]ican physician receives an impos+-look+ lett] be>+ ! ,pal]mo1 ,sicily1 po/m>k & address$ to 8,monsieur le ,docteur ,john ,doe1 ,mdec940 ,on op5+ ! lett] 8,monsieur le ,docteur0 f9ds t ! 8,c\ncil0 ( l',acadmie ,physico-,*imique ,itali5ne has nom9at$ him 8,honor>y ,memb] ( ?is ,academy0 & fur!rmore has be/[$ on him 8a ,fir/ ,class ,m$al = te*nical "w & sci5tific m]it40 ,all ?is1 89 consid]ation ( y\r _m dignities & great le>n+40 ,dr4 ,doe is told t z soon z he w write an acceptance ( ?is honor 89 con=mity ) ,section #ai & #bb ( ! ,con/itution0 he w be s5t 8! ,m$al1 ,diploma & all ! o!r docum5ts relat+ to ! title accord$40 ,! jok] 9 ! s*eme lies 9 ! necessity = ,dr4 ,john ,doe 8con=m+0 ) 8,section #ai & #bb ( ! ,con/itution40 ,"h are ! sections3 ,illu/ration3 ,r$uc$ photographic reproduction ( ! /ock lett] s5t to ,am]ican physicians by ! ,italian ,physico-,*emical ,academy4 ,! 8jok]0 lies 9 ! requirem5t ar\nd :i* we h drawn a l9e4 8,sec4 #ai4--,! entrance fee to cov] (fice & po/al exp5ses1 includ+ po/age ( diploma is #e ,doll>s1 & is payable once at ! admission to ! ,academy by special bullet9 fill$ up1 /amp$ & sign$40 8,sec4 #bb4--,^? to :om m$als are aw>d$ & :o wi% to possess !m mu/ pay = _! co9age #aj ,doll>s z ! ,academy does n1 at pres5t1 possess ! necess>y funds = ?is purpose44440 ,9 %ort ! :ole ?+ means t if ,dr4 ,doe is will+ to s5d #ae 9 good ,am]ican money he w receive 9 due "t f ! academy a 8diploma0 & a gilt 7n gold7 m$al4 ,ab\t f\r ye>s ago :5 ! 8,academy0 seem$ to be mak+ a p>ticul>ly heavy bid = ,am]ican doll>s ! memb] ( ,! ,j\rnal /aff 9 *>ge ( ! ,propag&a ,dep>tm5t wrote to ! 8,academy10 on 8 p]sonal /ation]y1 ask+ ab\t ! co/ ( memb]%ip 9 ! 8,academy0 & ask+ also = a copy ( ! 8prospectus40 ,& t 0 all4 ,9 reply he receiv$ a lett] /at+ t 89 consid]ation (0 8 8_m dignities & great le>n+0 he _h be5 nom9at$ 8an (fic] ( ?is academy0 & _h be5 aw>d$ 8la mdaille de premire classe0 = humanit>ian "w & sci5tific m]it4 ,9 ord] to obta9 ^! tok5s ( ! 8,academy's0 reg>d x w\ld be necess>y to in=m ! 8,academy0 ( acceptance 89 con=mity ) ,section #ai & #bb 4440 ,z ! ,propag&a ,dep>tm5t did n consid] ! diploma & gilt m$al wor? #ae ev5 z exhibit = its museum ( fakes1 ! 8,=m ( ,acceptance0 0 n fill$ 9 & return$ 89 accordance ) ,section #ai & #bb40 ,illu/ration3 ,photographic reproduction 7r$uc$7 ( ! 8,=m ( ,acceptance0 to 8memb]%ip0 9 ! 8,italian ,physico-,*emical ,academy40 ,fill+ out ?is blank & s5d+ x ) #ae4jj to ! 8,academy0 w br+ ! gilt m$al & 8diploma40 ,! lead+ spirits 9 ! op]ation ( ?is diploma & m$al mill are ,d4 & ,g4 ,b&i]a1 :o1 s f> z we c le>n1 are nei!r physicians nor ph>maci/s nor h any sci5tific /&+4 ,! 8,academy0 has be5 ref]r$ to at v>i\s times#bid by ,! ,j\rnal4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,feb4 #bf1 #aiaf47 #bid ,j4 ,a4 ,m4 ,a4 #dh3 #baif 7,june #bi7 #aijg2 ,editorial #eg3 #acgc1 ,b]l9 lett]1 p4 #achj 7,oct4 #ba7 #aiaa2 #eh3 #adee 7,may #aa7 #aiab2 #fj3 #ggj 7,m>* #h7 #aiac2 #fj3 #adhj 7,may #aj7 #aiac2 #fa3 #agcg 7,nov4 #h7 #aiac4 ,,:at ,,is ,,liquid ,,petrolatum8 ,! use ( liquid petrolatum 9 *ronic con/ipation1 :i* has rec5tly become ! vogue1 has naturally be5 comm]cializ$2 z a result1 also naturally1 claims ( sup]iority ( "o br& ov] ano!r h be5 made4 ,"s ( ^! claims may h be5 well f\nd$2 o!rs c]ta9ly are n4 ,"s h claim$ sup]iority = ^? products made f ,russian oil ov] ^? made f ,am]ican oils4 ,z naph!ne hydroc>bons pr$om9ate 9 ,russian crude petroleums1 & p>aff9 hydroc>bons 9 _m or mo/ ,am]ican crude petroleums1 x 0 assum$ t ! petrolatums d]iv$ f ^! s\rces diff]$ f "o ano!r 9 l mann]4 ,bo? ! naph!nes & ! p>aff9s are *emically in]t2 b "s unexpla9$ !rapeutic sup]iority has be5 assum$ to reside 9 ! naph!nes4 ,consequ5tly1 x has be5 urg$ t ! ,am]ican liquid petrolatums %\ld n be us$ int]nally4 ,s f> ^! claims & c\nt]claims h be5 bas$ on mu* !ory & little fact4 ,! ,j\rnal publi%es ?is week a contribution by ,b5jam9 ,t4 ,brooks1 ,s5ior ,fell[ 9 *>ge ( petroleum inve/igations at ,mellon ,in/itute1 ,pittsburgh4 ,brooks calls att5tion to ! fact t ,m>cusson1 9 #aiac1 po9t$ out t mo/ ( ! s-call$ 8m9]al oils0 us$ = !rapeutic purposes conta9 no p>aff9 hydroc>bons :atev]2 t !y consi/ solely ( naph!nes & polynaph!nes4 ,brooks confirms ?is /atem5t s f> z ,am]ican liquid petrolatums are conc]n$4 ,he /ates t _m ,am]ican petroleums1 su* z mo/ ( ^? f ! ,gulf region1 are l ! ,russian 9 conta9+ no p>aff92 & t1 9 ! case ( ^? petroleums t d conta9 x1 ! cu/om>y ref9]y me?od ( remov+ p>aff9 is suffici5t to produce true naph!ne & polynaph!ne petrolatums4 8,! claim t only ,russian oils belong 9 ?is class10 he says1 8has no basis 9 fact & has be5 advanc$ presumably = bus9ess reasons40 ,! "n 8p>aff9 oil0 appli$ to ^! liquid petrolatums1 !n1 is a misnom]4 ,! new "n1 8:ite naph!ne oils10 sugge/$ by ,brooks1 seems sup]flu\s1 h[ev]1 s9ce ! ph>macopeial title1 8liquid petrolatum10 is subject to no su* objection4--7,editorial f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #a1 #aiaf47 ,,! ,,l[5?al ,,po/graduate ,,c\rse ,:i* ,tells ,h[ to ,make ,diagnoses ,accurately1 ,sci5tifically ,*eck ! ,*ri/ian ,sci5ti/s & ,increase ,y\r ,e>n+ ,p[] ,dur+ ! pa/ ye> ,! ,j\rnal has receiv$ lett]s f physicians 9 v>i\s cities ask+ = in=mation reg>d+ ! 8,po/ ,graduate ,c\rse ( ,lectures & ,cl9ics on ,n]v\s & ,m5tal ,diseases0 :i* 0 go+ to be giv5 9 _! respective cities by ,dr4 ,alb]t ,a4 ,l[5?al ( ,*icago4 ,! foll[+ inquiries are typical3 8,to ! ,editor4--,please note ! enclos$ lett] f ! ,am]ican ,organo!rapy ,company :i* appe>s to be conduct$ by ,l[5?al4 ,! proposition ( conduct+ ^! cl9ics impresses me z a piece ( colossal gall :i* is amaz+ ev5 9 ^! days4 ,d y "k any?+ ab\t ?is matt]80 8,to ! ,editor4--,:o ! dick5s is ,alb]t ,a4 ,l[5?al1 ,m4,d48 ,note ! circul> enclos$4 ,i h blue circl$ ! rem>ks he evid5tly ?9ks w attract40 ,9 ,may1 #aiai1 ,*icago physicians receiv$ a =m lett]1 sign$1 & on ! /ation]y (1 ,alb]t ,a4 ,l[5?al1 notify+ !m t ,dr4 ,l[5?al 0 ab\t to 8give a ,po/ ,graduate ,c\rse ( ,lectures & ,cl9ics on n]v\s & m5tal diseases0 9 ! 8,banquet ,hall1 ,morrison ,hotel40 ,enclos$ 0 a 8,programme & ,res]vation ,c>d0 & a self-address$ envelop = physicians to notify ,dr4 ,l[5?al t !y w\ld be pres5t4 ,9 addition to %[+ physicians 8h[ to make diagnoses accurately10 ,dr4 ,l[5?al (f]$ to 8expla9 fully h[ to sci5tifically *eck ! ,*ri/ian ,sci5ti/s & increase y\r e>n+ p[]60 ,& all = no?+6 ,at lat] dates simil> lett]s 7 receiv$ by physicians 9 o!r cities1 on ! /ation]y ( ! 8,am]ican ,organo!rapy ,company1 ,room #ijb1 #ca ,nor? ,/ate ,/41 ,*icago40 ,dr4 ,l[5?al1 ^: ,*icago (fice is ,room #ija1 #ca ,nor? ,/ate ,/41 is1 app>5tly1 presid5t1 treasur] & practical own] ( ?is company4 ,enclos$ ) ea* ( ^! lett]s--:i* (f]$ ! same inducem5ts1 free--0 an envelop address$ to ,alb]t ,a4 ,l[5?al 9 c>e ( ! hotel at :i* ,dr4 ,l[5?al w\ld /ay :ile 9 t city4 ,!re 0 also a 8,programme & ,res]vation ,c>d0 z 9 ! case ( ! lett]s s5t to ,*icago physicians4 ,accord+ to our records1 ,dr4 ,alb]t ,a4 ,l[5?al 0 born 9 ,*icago 9 #ahgd & 0 graduat$ by ! ,college ( ,physicians & ,surgeons1 ,*icago1 9 #ahie1 receiv+ 8 lic5se ! same ye>4 ,9 a leaflet issu$ "s "t ago by ,alb]t ,a4 ,l[5?al1 ,m4,d41 8= ! sole purpose ( enlight5+ ,prospective ,pati5ts 9 reg>d to ! !rapeutic value ( ! ,organo ,!rapy ,treatm5t = ,n]v\s ,diseases10 we le>n t ,dr4 ,l[5?al is1 or 03 8,pr(essor ,n]v\s & ,m5tal ,diseases1 ,*icago ,hospital ,college ( ,m$ic9e40 8,=m]ly ,pr(essor ,n]v\s & ,m5tal ,diseases1 ,de>born ,m$ical ,college1 ,j5n] ,m$ical ,college40 8,adjunct ,pr(essor on ,neurology & ,psy*iatry1 ,univ]sity ( ,ill9ois ,college ( ,m$ic9e40 8,=m]ly ,physician ,ill9ois ,ea/]n ,hospital = ! ,insane40 8,=m]ly ,supt41 ,riv]view ,hospital = ,n]v\s ,diseases1 ,kankakee1 ,ill40 8,=m]ly on ,advisory & ,associat$ ,att5d+ ,/aff ,cook ,c\nty ,hospital40 ,9 ,polk's ,m$ical ,directory = #aijd1 ,dr4 ,alb]t ,a4 ,l[5?al's "n appe>$1 "u ,*icago1 at #iaj-iab ,*icago ,op]a ,h\se ,build+4 ,he 0 describ$ z 8,sup]9t5d5t ( ,l[5?al's ,sanit>ium40 ,9 ! same issue ( ! directory1 !re 0 a display adv]tisem5t ( ! ,l[5?al ,sanit>ium1 :i*1 :ile locat$ at ,kankakee1 ,ill41 _h its 8ma9 (fices0 at #iab ,*icago ,op]a ,h\se ,bldg41 ,*icago4 ,! adv]tisem5t 0 head$ 8,,goat ,,lymph ,,treatm5t10 & read 9 "p3 8,goat ,lymph has revolutioniz$ m$ic9e1 & has be5 adopt$ by ! sci5tific m$ical _w z ! only !rapeutical ag5t t w absolutely br+ ab\t positive results 9 *ronic conditions1 su* z ,neura/h5ia1 ,n]v\s ,collapse1 ,p>alysis1 ,locomotor ,ataxia1 ,bra9 ,fag1 ,oncom+ ,insanity1 ,*ronic ,/oma* ,disord]s1 9 fact su* diseases ne$+ cell /imulation40 ,x m5tion$ fur!r t ,dr4 ,alb]t ,l[5?al 8introduc$ ,goat ,lymph to ! m$ical _w z a curative ag5t40 ,a few ye>s ago a ,*icago conc]n1 kn[n z ! 8,am]ican ,animal ,!rapy ,co410 put out su* products z 8,lymphoid ,comp\nd 7,l[5?al710 8,ova ,mammoid 7,l[5?al710 8,pro/oid 7,l[5?al710 etc4 ,! ,am]ican ,animal ,!rapy ,co4 _h = its manag] ,james ,m4 ,ra9ey4 ,ra9ey also op]at$ ! 8,ra9ey ,m$ic9e ,co410 a mail-ord] 8pat5t m$ic9e0 conc]n t sold 8,vital9e10 a 8g5]al debility cure40 ,! ,ra9ey 8,vital9e0 quack]y 0 expos$ 9 ,! ,j\rnal1 ,oct4 #a1 #aiaj1 & ! matt] appe>s 9 8,no/rums & ,quack]y40 ,:5 ! ,am]ican ,animal ,!rapy ,company 0 op]at+ f #hd ,adams ,/41 ,*icago1 x claim$ to h a hospital & laboratory at ,kankakee4 ,at ! same "t lett]s 7 be+ s5t out on ! /ation]y ( 8,! ,lymph ,hospital10 sign$ ,alb]t ,a4 ,l[5?al1 ,m4,d4 ,al?\gh ?is 8hospital0 0 at ,kankakee1 ,ill41 ! address on ! /ation]y 0 #hd ,adams ,/41 ,*icago1 & its telephone numb] 0 t ( ! ,am]ican ,animal ,!rapy ,company4 ,accord+ to ! /ation]y1 ! 8,m$ical ,dep>tm5t0 ( ! ,lymph ,hospital 0 8"u ! p]sonal direction ( ,dr4 ,alb]t ,a4 ,l[5?al1 :o introduc$ ! ,lymph ,comp\nd & ,lymphoid ,comp\nd to ! ,sci5tific ,m$ical ,_w z a curative ag5t 9 ,*ronic ,n]v\s conditions40 ,a layman receiv$ a lett] f ! 8,lymph ,hospital0 urg+ him to take 8,lymphoid ,comp\nd40 ,lat] he receiv$ a 8foll[-up0 lett]1 f :i* ! foll[+ extracts are made4 ,capitals us$ z 9 ! orig9al3 ,illu/ration3 ,"s lett]heads 7greatly r$uc$7 ( conc]ns 9 :i* ,dr4 ,alb]t ,a4 ,l[5?al has be5 int]e/$4 8,d y "k t ! doctors ( ?is c\ntry are us+ ! ,,lymphoid ,,comp\nd ,,exclusively 9 all cases1 :]e ! n]v\s sy/em is greatly involv$1 ) ! mo/ ,,m>vel\s ,,results4 ,,isn',t ,,t ,,suffici5t ,,pro( z to ! m]it ( ! rem$y80 8444 ,nobody c tell y !re is some?+ j z good1 because ,,!re ,,is ,,no?+ ,,j ,,z ,,good ,,z ,,! ,,lymph--9 fact ,,x ,,is ,,! ,,only ,,?+ ,,t ,,c ,,be ,,dep5d$ ,,^u40 8444 ,our ,dr4 ,l[5?al gives 8 p]sonal att5tion to all cases at ! ,hospital & devotes a portion ( 8 "t advis+ by mail ^? p]sons "u treatm5t :o are unable to come to ! ,hospital4 ,he is a man ( ,,_w ,,wide ,,reputation ,,9 ,,treat+ ,,n]v\s ,,diseases--,,8 ,,advice ,,on ,,cases ,,l ,,y\rs ,,is ,,wor? ,,ev]y?+ ,,to ,,y40 8,?9k ?is ov] & if y d1 y w write an ord] today = ! ,lymphoid ,comp\nd4 ,! home treatm5t co/s #i4ej = ?irty ?ree days--?9k ( t4 ,y h our physician's advice & c>e free ( *>ge--c\ld anybody (t] m to y80 ,9 #aijh ,dr4 ,l[5?al appe>$ z a witness = ,edw>d ,r4 ,hibb>d1 :o 0 be+ prosecut$ by ! f$]al au?orities4 ,hibb>d op]at$ a 8m5's speciali/0 (fice 9 ,*icago2 x _h two entrances & a diff]5t "n = ea* entrance--! 8,bo/on ,m$ical ,in/itute0 & ! 8,bellevue ,m$ical ,in/itute40 ,hibb>d 0 f\nd guilty ( fraud 9 ! op]ation ( ?is conc]n & 0 f9$ #a1ejj4 ,! transcript ( ! te/imony 9 ! ,hibb>d case records t ,dr4 ,alb]t ,a4 ,l[5?al1 :5 on ! /&1 claim$ to 8h treat$ z _m n]ve pati5ts z any n]ve speciali/ 9 ,*icago40 ,he fur!r decl>$1 accord+ to ! transcript1 t physicians :o make a specialty ( n]v\s diseases 8mature 9 ab\t t5 ye>s0 & t aft] t "t mo/ ( !m become n]v\s wrecks or insane4 ,?is 0 9 #aijh4 ,9 ?is connection x is wor? not+ t 9 lett]s s5t out by ,l[5?al 9 ,may1 #aiai1 he claim$3 8,9 ! pa/ tw5ty-five ye>s ,i h limit$ my "w to neurological & psy*ological cases44440 ,9 #aijh also1 ,dr4 ,l[5?al 0 s5d+ out lett]s to ,ill9ois physicians 9 8 capacity z secret>y ( ! 8,physicians' ,league ( ,ill9ois40 ,! 8league0 issu$ a 8report on c&idates = gov]nor & memb]s ( legislature10 giv+ ! names ( ! v>i\s political c&idates = (fice :om 8! memb]s ( ! league c safely support40 ,!re 7 no 8memb]%ip0 fees & a physician :o wrote ask+ 8:o foots ! bills0 receiv$ no reply4 ,9 #aiae ,alb]t ,a4 ,l[5?al1 ^: 8valuable discov]ies 9 ! doma9s ( ,organo ,!rapy1 ,neurology & ,p$iatrics1 h giv5 him an int]national reputation z a ,neurologi/1 ,ali5i/ & ,climatological ,exp]t ( high /&+10 0 8,m$ical ,sup]9t5d5t0 ( ! 8,national ,sanit>ium ,in=mation ,bureau40 ,?is purport$ to repres5t ! 8,lead+ ,sanit>iums & ,heal? ,resorts 9 ! ,u4 ,s40 ,! 8,bureau0 expect$ to make its 8pr(it f ! #aj p] c5t4 honor>ium receiv$ on e ref]r$ pati5t40 ,! 8,bus9ess ,manag]0 ( ?is conc]n 0 "o ,hub]t ,mill]1 ,m4,d4 ,! foll[+ adv]tisem5t appe>$ 9 ! classifi$ dep>tm5t ( ! ,/4 ,l\is ,po/ ,dispat* 9 #aiae3 ,illu/ration ,a layman :o wrote 9 answ] to ?is adv]tisem5t receiv$ a lett] f ,dr4 ,l[5?al 9 :i* he said t x 0 8 int5tion to take ab\t ?irty pati5ts s\? ) him = f\r mon?s--co/ ( trip #ejj1 :i* includes m$ical treatm5t1 bo>d1 etc4 ,dr4 ,l[5?al /at$ fur!r3 8,i h treat$ probably m cases ( ,locomotor ,ataxia & ,p>alysis ?an any ,physician 9 ,unit$ ,/ates & c hone/ly /ate t ) ,organo ,!rapy ,treatm5t y\r walk c be improv$ & pa9s controll$40 ,9 ,m>*1 #aiai1 ,dr4 ,l[5?al paid a visit to ,spokane1 ,wa%41 & ,portl&1 ,ore4 ,a ,portl& pap] h]ald$ 8 com+ & pr9t$ a picture ( 8,dr4 ,a4 ,a4 ,l[5?al1 ,_w fam\s ali5i/40 ,! pap] describ$ ,dr4 ,l[5?al z 8! ali5i/ consult$ 9 ! ,h>ry ,?aw case0 & ! "o 8:o treat$ ,john ,alex&] ,d[ie ( ,zion ,city fame & ,pope ,leo ,,xiii40 ,! fulsome puff]y t ,dr4 ,l[5?al got :ile 9 ,spokane drew criticism f "o or two memb]s ( ! local m$ical pr(ession1 :o wrote to ! newspap]s prote/+4 ,"o ( ! physicians :o ?us wrote decl>$ t ,l[5?al's 8com+ 0 ann\nc$ 9 a circul> s5t ?r\gh ! ,owl ,drug ,company :i* is ag5t = ! sale ( products ( an organo-!rapy company40 ,app>5tly1 x 0 aft] ,dr4 ,l[5?al's return f ! ,pacific ,coa/ t he comm5c$ to ann\nce 8 8,po/-,graduate ,c\rse ( ,lectures & ,cl9ics0 to ! physicians ( ,*icago1 ,d5v]1 ,/4 ,l\is1 ,columbus1 etc4--&1 incid5tally1 to br+ to ! att5tion ( ! m$ical _w ! alleg$ virtues ( ! products ( ! ,am]ican ,organo-,!rapy ,company4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,july #c1 #aibj47 ,,m$ical ,,society ,,( ,,! ,,unit$ ,,/ates ,f 8,division ( ,fees0 to 8,d[n ) ,autocracy0 ,! 8,m$ical ,society ( ! ,unit$ ,/ates0 has = its 8,honor>y ,presid5t0 "o ,a4 ,h4 ,ohmann-,dumesnil1 ,a4,m41 ,m4,d41 ,m4,e41 ,sc4,d41 ,ph4,d41 & = its 8,secret>y & ,treasur]0 "o ,emory ,lanphe>1 ,m4,d41 ,c4,m41 ,ph4,d41 ,,ll4,d4 ,z orig9ally plann$1 ! 8society0 seems to h be5 bas$ on ! idea ( organiz+ ! 8fee-splitt]s40 ,9 ,may1 #aiaf1 ! bir? ( ! organization 0 ann\nc$ to ! m$ical pr(ession ?r\gh a lett] sign$ ,emory ,lanphe>1 writt5 on ! /ation]y ( ! 8,m$ical ,society ( ! ,unit$ ,/ates40 ,ev5 9 its embryonic /ate ! society _h ,a4 ,h4 ,ohmann-,dumesnil1 ,a4,m41 ,m4,d41 ,m4,e41 = its presid5t1 & ,emory ,lanphe>1 ,m4,d41 ,ph4,d41 ,,ll4,d41 z its treasur]4 ,! lett] read 9 "p3 8,we--! majority ( ! m$ical pr(ession--:o believe 9 division ( fees 7i4 e41 t ! surgeon %\ld n #8hog' ! :ole ( a pati5t's money & leave no?+ = ! family doctor71 are no long] welcome 9 ! ,a4 ,m4 ,a4 ,we are !re=e organiz+ ! ,m$ical ,society ( ! ,unit$ ,/ates1 :i* w n be conduct$ = ! b5efit ( a few selfi% egoti/s4 ,we w\ld l to h y ) u4 8,x co/s only #a4jj to jo94 ,?is cov]s dues = #aiaf1 & includes exp5se = ! beautiful c]tificate ( memb]%ip 7suitable = fram+71 :i* y w receive on admission4 ,fill enclos$ blank & return to me ) #a4jj40 ,b presumably ! idea ( organiz+ on a basis ( 8fee splitt+0 did n make a hit1 s ! lure 0 *ang$4 ,today physicians are approa*$ ) ! plea t ! 8,m$ical ,society ( ! ,unit$ ,/ates0 w make ! m$ical _w free = democracy2 x is1 we are assur$1 a 8,society ( ,prote/ ,aga9/ ! ,autocracy ( ! ,a4 ,m4 ,a410 & a 8,society ( ,m$ical ,democracy40 ,memb]%ip co/s 8only #a4jj 444 includ+ ! co/ ( a beautiful c]tificate ( memb]%ip40 ,no p5alties or puni%m5ts are involv$ = belong+ to o!r societies1 &3 8,jo9+ our body ne$ n affect y\r memb]%ip 9 any o!r society--ev5 ! ,a4 ,m4 ,a41 if y wi% to belong to x1 & be #8boss$' by ! #8,simmons ,gang'40 ,! doll> = ! 8beautiful c]tificate0 & memb]%ip is solicit$ by means ( circul> lett]s sign$ 8,emory ,lanphe>10 com+ f #cddg ,p9e ,/41 ,/4 ,l\is1 ,mo41 ! address ( :at has be5 v>i\sly call$ ! 8,am]ican ,polycl9ic10 ! 8,am]ican ,hospital10 & lat]1 ! 8,g]man ,hospital40 ,! 8,surgeon-9-,*>ge0 ( ! 8,g]man ,hospital0 is ,emory ,lanphe>1 ,m4,d41 ,c4,m41 ,ph4,d41 ,,ll4,d4 ,:5 runn+ "u ! "n ( ! 8,am]ican ,hospital10 ,lanphe> solicit$ op]ative "w on a 8division ( fees0 basis1 :i*1 ! g5]al practition] 0 told1 meant t 8y are to h #dj p] c5t4 ( all fees receiv$ f y\r pati5ts s5t to our /aff = op]ation or treatm5t40 ,) ! *ange 9 "n f 8,am]ican ,hospital10 to 8,g]man ,hospital10 ,lanphe> appeal$ = a 8portion ( y\r op]ative "w on a basis ( pure reciprocity40 ,?is 8pure reciprocity0 seems to h be5 a /ill m lib]al di/ribution ( ! pati5t's money1 = f a #dj p] c5t4 basis x 0 rais$ to an ev5 fifty-fifty4 ,said ,lanphe>1 9 a lett] s5t out a few mon?s ago3 ,illu/ration3 ,! 8,m$ical ,society ( ! ,unit$ ,/ates10 0 orig9ally organiz$ on a basis ( 8fee-splitt+10 z is %[n by ! r$uc$ facsimile ( a lett] s5t broadca/ 9 #aiaf1 ann\nc+ ! bir? ( ! new 8society40 ,app>5tly1 8fee-splitt+0 z a rally+ po9t did n br+ 9 ! desir$ returns1 s today ! 8,m$ical ,society ( ! ,unit$ ,/ates0 is alleg$ to be a 8,society ( ,prote/ ,aga9/ ! ,autocracy ( ! ,a4 ,m4 ,a40 8,i wi% also to in=m y 9 spite ( ! despicable opposition ( ! hypocritical gang 9 *>ge ( ! ,a4 ,m4 ,a41 & ! no less contemptible action ( ! ,/4 ,l\is ,m$ical ,society1 ,i am go+ to rema9 9 ,/4 ,l\is & cont9ue to d surgical "w ^u a #8division ( fee' basis4 ,to be m explicit1 if y br+ me a case = op]ation ,i %all all[ y "o half ( ! fee = y\r "t1 tr\ble1 responsibility & help 9 ! managem5t ( ! case40 ,be=e leav+ ! int]e/+ pr(essional p]sonality ( ,lanphe>1 & c>efully avoid+ any details ( a p]sonal nature1 we may rem9d our read]s t z long ago z #aijh ,lanphe> 0 ! 8,dean0 ( ! 8,hippocratean ,college ( ,m$ic9e10 ) ,a4 ,h4 ,ohmann-,dumesnil1 ,a4,m41 ,m4,d41 ,m4,e41 ,sc4,d41 8,vice-,dean40 ,at t "t ,lanphe> s5t out lett]s to physicians propos+ ! organization ( a 8,po/ ,graduate ,faculty0 on ! foll[+ basis3 8,^? :o hold full pr(essor%ips %all pur*ase /ock 9 ! corporation to ! am\nt ( #a1jjj4jj2 ^? :o become lectur]s or in/ructors %all pay 9 ! sum ( #ejj4jj2 ^? :o are to be m]ely cl9ical assi/ants w buy t5 %>es ( /ock1 #ajj4jj40 ,! 8,hippocratean ,college0 0 a 8sund[n0 affair2 x nev] graduat$ a /ud5t1 & expir$ 9 #aiaj4 ,illu/ration3 ,r$uc$ facsimile ( ! lett]-heads ( an in/itution kn[n v>i\sly z ! 8,am]ican ,hospital0 & ! 8,g]man ,hospital40 ,! *ange 9 "n f 8,am]ican0 to 8,g]man0 seems to h tak5 place e>ly 9 #aiae--:5 ?+s ,g]man 7 m popul> & pr(itable ?an !y are today6 ,b to come back to ! 8,society ( ,m$ical ,democracy03 ,! 8,m$ical ,society ( ! ,unit$ ,/ates0 seems to h be5 born 9 #aiaf4 ,its p>5ts1 s f> z is app>5t1 seem to h be5 ,lanphe> & ,ohmann-,dumesnil4 ,! latt]1 x may be rememb]$1 us$ to be ! editor & proprietor ( ! ,/4 ,l\is ,m$ical & ,surgical ,j\rnal1 a publication s obvi\sly v5al1 t its value to ! no/rum mak]s1 ^: int]e/s x esp\s$1 mu/ h be5 small4 ,adv]tis+ pages1 8orig9al articles0 & 8editorials0--all 7 us$ to puff no/rums ( ! crude/ type4 ,x 0 ,ohmann-,dumesnil & 8 j\rnal t came to ! def5se ( ! 8pat5t m$ic9e0 int]e/s :5 !y 7 s h>d hit by ,mr4 ,adam's 8,great ,am]ican ,fraud0 s]ies4 ,9 comm5t+ on ?is phase ( 8pat5t m$ic9e0 activities1 ,colli]'s1 9 ,janu>y1 #aijg1 said3 8,heada*e p[d]s came 9 = a consid]able %>e ( att5tion 9 ! pat5t m$ic9e articles4 ,!re 0 mu* talk ( libels among ! heada*e p[d] mak]s1 b !y decid$ ^u ! saf] me?ods ( hir+ a m]etrici\s m$ical publication1 ! ,/4 ,l\is ,m$ical & ,surgical ,j\rnal1 to pr9t an article 9 :i* ! ,colli]'s /atem5ts 7 br&$ z lies1 & ! ,colli]'s editors & writ]s z li>s & libel]s4 ,?is article ! ,propriet>y ,association ( ,am]ica circulat$ 9 pamphlet =m4 ,! j\rnal :i* pr9t$ x di$ a natural dea? a few weeks lat]4 ,its editor1 "o ,a4 ,h4 ,ohmann-,dumesnil1 has j appe>$ 9 ! public pr9ts 9 an unsavory connection ) a corrupt lobby+ project 9 ,/4 ,l\is40 ,"s ( ! no/rums t ,ohmann-,dumesnil has recomm5d$ are3 8,sanmetto10 8,gonosan10 8,cact9a ,pillets10 8,pepto-,mangan10 8,satyria10 8,campho-,ph5ique10 8,tongal9e10 8,g]miletum10 8,n>kog510 8,nosoph510 8,m]cauro10 8,ars5auro10 & 8,hydrozone40 ,_m ( ^! te/imonials 71 ( c\rse1 us$ by ! manufactur]s 9 _! adv]tis+ 8lit]ature40 ,at ! "t t ! ,m$ical ,society ( ! ,unit$ ,/ates 0 be+ organiz$--9 #aiaf--!re 0 publi%$ :at purport$ to be a prelim9>y program ( its fir/ meet+4 ,! meet+ 0 held 9 ,/4 ,l\is1 & ! program1 :ile conta9+ ! names ( m5 ) special fads or int]e/s to exploit1 also conta9$ ! names ( "s m5 ( /&+4 ,x appe>$1 h[ev]1 on inve/igation1 t at lea/ "s ( ! latt] _h b a hazy conception ( ! use to :i* _! names 7 be+ put1 & prote/$ vigor\sly on le>n+ ! facts1 repudiat+ ! organization4 ,illu/ration3 ,r$uc$ facsimile ( a lett] s5t out 9 #aiab1 solicit+ ! pur*as+ ( /ock 9 ! 8,am]ican ,hospital0 on a division ( fee basis--=ty-sixty6 ,n[1 9 #aiah1 ano!r drive is on = memb]%ip2 lett]s sign$ 8,emory ,lanphe>0 are be+ s5t to v>i\s select$ gr\ps ( physicians4 ,= example1 ! ,eclectics are be+ coax$ by a lett] :i* comm5ces3 8,we want e reputable ,eclectic practition] 9 ?is c\ntry to jo9 our society ( prote/ aga9/ ! iniquities ( ! ,a4 ,m4 ,a40 ,an id5tical lett] has be5 address$ to ,homeopa?s1 ! words 8,homeopa?ic practition]0 be+ sub/itut$ = 8,eclectic practition]s40 ,9 all ( ! lett]s ! 8beautiful c]tificate ( memb]%ip0 is emphasiz$1 & ! trivial co/--8only #a4jj a ye>0--is ref]r$ to1 :ile ! plea3 8surely y are will+ to help to t am\nt to #8d[n' ! #8gang' 9 *>ge ( ! ,a4 ,m4 ,a410 is featur$4 ,ano!r gr\p ( lett]s has gone out to ! graduates ( ! ,b>nes ,m$ical ,college4 ,?is comm5ces3 8,mo/ graduates ( #8,old ,b>nes' h jo9$ our society ( prote/ aga9/ ! iniquities ( ! ,a4 ,m4 ,a4 ,:y %\ld y also n come 98 ,x co/s only #a4jj to become a memb]1 includ+ ! co/ ( a beautiful c]tificate ( memb]%ip40 ,/ill ano!r gr\p appeal is bas$ on sex2 ?us ,lanphe>3 8,we want e reputable #8lady physician' 9 ?is c\ntry to jo9 our society ( prote/ aga9/ ! iniquities ( ! ,a4 ,m4 ,a40 ,& yet ano!r3 8,y =m]ly belong$ to ! ,tri-,/ate ,m$ical ,society1 ( :i* ,i 0 ,treasur] = #bj ye>s4 ,x is n[ dead4 ,i wi% y w\ld jo9 our new society :i* has sup]s$$ ,tri-,/ate 9 ?is t]ritory40 ,) ^! v>i\s lett]s is enclos$ a 8prelim9>y program0 ( ! #aiah meet+ :i* is to be held ,octob] #h & #i 9 ,*icago4 ,z might be expect$1 _m ( ! names on ! program are *>act]i/ic ( ! organization & an int]e/+ 8/ory0 might be made f ! mat]ial 9 ,! ,j\rnal's files on ! individuals4 ,su* names are ( m51 :o1 pr(essionally speak+1 range f faddi/s1 :o ride grotesque & biz>re m$ical hobbies1 to ^? :o ) special int]e/s to exploit & unable to use reputable m$ical organizations = t purpose1 take refuge 9 su* hybrid conglom]ations z ! ,m$ical ,society ( ! ,unit$ ,/ates4 ,n t ! program conta9s ! names ( crude quacks1 or obvi\s m$ical sw9dl]s4 ,x is repres5tative1 r1 ( t twilight zone ( pr(essionalism1 ! p5umbra1 9 ^: unc]ta9 light x is difficult to di/+ui% betwe5 ! unbalanc$ vision>y1 ) a fad1 & ! m s9i/] ne>-quack1 ) a 8s*eme40--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,oct4 #e1 #aiah47 ,,! ,,national ,,=mul>y--,a ,,review ,,( ,,! ,,f\r? ,,edition ,! f\r? edition ( ! ,national ,=mul>y appe>s simultane\sly ) ! ,u4 ,s4 ,ph>macopeia ,,ix1 & is to become (ficial at ! same "t 7,septemb] #a74 ,! pr9ciples :i* det]m9e its scope1 z frankly set =? 9 ! preface1 are app>5tly ! same z ^? appli$1 ?\gh m fa9t-he>t$ly1 9 ! compilation ( ! ,ph>macopeia4 ,a /atem5t 9 ! preface ( ! new ,national ,=mul>y runs3 8,! scope ( ! pres5t ,national ,=mul>y is ! same z 9 previ\s issues1 & is bas$ on m$ical usage r ?an on !rapeutic ideals4 ,! committee consi/s entirely ( ph>maci/s1 or ( m5 ) a ph>maceutical tra9+1 & x _c presume ei!r to judge !rapeutic practice or to foll[ any p>ticul> s*ool ( !rapeutic practice4 ,! "q ( ! addition or deletion ( any =mula 0 judg$ on ! basis ( its use by physicians & its ph>maceutical s\ndness4 ,! consid]able use by physicians ( any prep>ation 0 consid]$ suffici5t w>rant = ! inclusion ( its =mula 9 ! book1 & a negligible or dim9i%+ use z ju/ify+ its exclusion40 ,"p ,i ( ! volume conta9s =mulas1 good1 bad & indiff]5t1 includ+ ! equival5ts ( a l>ge numb] ( %otgun propriet>ies4 ,"p ,,ii conta9s descriptions ( drugs4 ,?is is a new feature4 ,! purpose is to provide /&>ds = ^? drugs n describ$ 9 ! ,ph>macopeia b us$ 9 ,n4 ,f4 prep>ations4 ,_m ( ^! drugs 7 describ$ 9 ! ,u4 ,s4 ,ph>macopeia ,,viii1 b h n be5 includ$ 9 ! n9? revision4 ,practically all are ei!r wor?less or sup]flu\s4 ,"p ,,iii conta9s descriptions ( special te/s & reag5ts4 ,among ! !rapeutically useful =mulas are ^? = aromatic ca/or oil1 emulsion ( ca/or oil1 sprays or nebulae1 solution ( alum9um acetate1 solution ( alum9um subacetate & w9e ( antimony4 ,! two la/ nam$ are also includ$ 9 8,useful ,drugs40 ,sev]al =mulas = new classes ( prep>ations :i* may or may n be f\nd sup]ior to old =ms are pa/e p5cils = ! application ( m$icam5ts to limit$ areas ( ! sk91 mulls1 :i* are o9tm5ts spread l pla/]s1 & fluidglyc]ates1 :i* are fluidextracts 9 :i* glyc]9 takes ! place ( alcohol4 ,x %\ld be not$ also t1 z a result ( criticism1 ! alcohol cont5t ( "s prep>ations has be5 r$uc$4 ,z a :ole1 ! pres5t edition ( ! ,national ,=mul>y1 l its pr$ecessors1 is 8ph>maceutically useful b n a !rapeutic necessity40 ,to say t x is n a !rapeutic necessity is to /ate ! matt] mildly1 s9ce mo/ ( ! =mulas & almo/ all ( ! drugs describ$ h be5 disc>d$ long s9ce by rational !rapeuti/s4 ,s long z !re are physicians :o prescribe !rapeutic mon/rosities1 h[ev]1 ! druggi/ %\ld h ! aid t is furni%$ by ?is book 9 comp\nd+ !m4 ,f ! ph>maci/'s po9t ( view1 !re=e1 ! book is a valuable "o4 ,physicians :o h a sci5tific tra9+ 9 ! ph>macology ( drugs w n want x2 o!rs w be bett] (f )\t ! temptations (f]$ by its _m irrational =mulas4--7,book ,review 9 ,! ,j\rnal ,a4 ,m4 ,a41 ,sept4 #b1 #aiaf47 ,,nonspecific ,,prote9 ,,!rapy ,! treatm5t by nonspecific me?ods 9 a s]ies ( cases ( influ5zal pneumonia has be5 ! subject ( two rec5t pap]s4#bie ,^! me?ods are a developm5t ( ! "w ( ,i*ikawa1 ,kraus1 ,ldke1 ,jobl+ & ,pet]s51 & o!rs on ! treatm5t ( typhoid fev] & ( ,mill] & ,lusk's "w on ar?ritis4 ,9 ! orig9al "w 9 ?is field x 0 recogniz$ t !re 7 c]ta9 inh]5t dang]s 9 ! me?od & t wide application w\ld be p]missible only ) ! greate/ caution & "u c>eful control4 #bie ,rob]ts1 ,dudley1 & ,c>y1 ,e4 ,g43 ,bact]ial ,prote9 ,injections 9 ,influ5zal ,pneumonia1 ,j4 ,a4 ,m4 ,a4 #gb3ibb 7,m>* #bi7 #aiai4 ,c[ie1 ,d4 ,m41 & ,beav51 ,p4 ,w43 ,nonspecific ,prote9 ,!rapy 9 ,influ5zal ,pneumonia1 ,j4 ,a4 ,m4 ,a4 #gb3aaag 7,april #ai7 #aiai4 ,:5 vacc9es & o!r toxic prote9 sub/ances are inject$ intrav5\sly a tra9 ( reactions takes place t includes3 7a7 a prim>y leukop5ia1 foll[$ by a leukocytosis2 7b7 a prim>y less5+ ( ! coagulability ( ! blood1 foll[$ aft] "s int]val by a r$uction ( ! coagulation "t2 7c7 a pron\nc$ lymphagogue effect1 ! fl[ ( lymph f ! ?oracic duct be+ increas$ ?reefold2 7d7 a hyp]p]i/alsis ( ! inte/9al tract1 & 7e7 a m>k$ splan*nic engorgem5t ) a result+ l[]+ ( ! sy/emic blood pressure4 ,! alt]ation ( ! coagulability ( ! blood1 toge!r ) ! vascul> engorgem5t ( ! splan*nic area & ! co9cid5t increase 9 motility ( ! inte/9al tract t foll[ ! !rapeutic injection1 all t5d to increase ! possibility ( inte/9al hemorrhage4 ,prote9 !rapy is !re=e n a safe proc$ure 9 ?is p>ticul> disease4 ,t we are able to t]m9ate a c]ta9 numb] ( cases ( typhoid fev] by crisis by means ( su* injections is ( v great int]e/ f a !oretical po9t ( view4 ,9 ! treatm5t ( ar?ritis1 ! results seem mu* m satisfactory4 ,! "w ( ,mill] & ,lusk#bif has be5 confirm$ by a numb] ( obs]v]s1 among !m ,culv]1 ,cecil1 ,snyd]1 ,c[ie & ,calh\n2 & !re seems little d\bt t we may be able to give prompt relief & ev5 p]man5t fre$om f symptoms 9 a consid]able p]c5tage ( cases ( acute & subacute ar?ritis1 especially ^? class$ z ( rheumatic orig9--& ?is ) practically no risk to ! pati5t4 #bif ,mill]1 ,j4 ,l41 & ,lusk1 ,f4 ,b43 ,! ,treatm5t ( ,ar?ritis by ! ,intrav5\s ,injection ( ,=eign ,prote91 ,j4 ,a4 ,m4 ,a4 #ff3 #agef 7,june #c7 #aiaf2 ,! ,use ( ,=eign ,prote9 9 ! ,treatm5t ( ,ar?ritis1 ibid4 #fg3 #bjaj 7,dec4 #cj7 #aiaf4 ,z ) o!r new !rapeutic measures1 !re is /ill "s unc]ta9ty z to ! prop] dosage1 :i* is a matt] ( consid]able importance1 9 ord] to arrive at a j e/imate ( ! relative advantage or dang] 9 ! treatm5t4 ,typhoid vacc9es h be5 ext5sively us$ because !y are readily procur$ & give a prompt & %>p reaction4 ,h[ev]1 !y h ! disadvantage ( inexactitude 9 ! bact]ial c\nt1 z well z be+ ( v>y+ degrees ( toxicity1 ! latt] factor dep5d+ n only on ! use ( diff]5t /ra9s ( bact]ia 9 _! prep>ation b on ! age ( ! vacc9e4 ,synd]1#big z well z o!r work]s1 is ( ! op9ion t ! prim>y dose %\ld be small--f five to t5 million organisms--& t ! dose ( typhoid bacilli inject$ %\ld nev] exce$ two hundr$ & fifty million4 ,:ile a %>p reaction on ! "p ( ! pati5t is app>5tly a desid]atum1 a suffici5t response c usually be elicit$ ) a relatively small dose4 ,!re is no object 9 subject+ ! pati5t to ! risk ( ! pr(\nd depression t foll[s occasionally 9 ! wake ( l>ge doses4 ,inde$1 ! only s]i\s results s f> ascrib$ z due to ?is =m ( !rapy h foll[$ v l>ge doses or ! use ( relatively l>ge doses 9 moribund pati5ts2 or su* unreasonable proc$ures z ! intrav5\s injection ( milk4 ,x is true t milk injections 7 recomm5d$ by "s ( ! ,g]man inve/igators1 b !y 7 always us$ intramuscul>ly4 #big ,snyd]1 ,r4 ,g43 ,a ,cl9ical ,report ( ,nonspecific ,prote9 ,!rapy 9 ! ,treatm5t ( ,ar?ritis1 ,ar*4 ,int4 ,m$4 #bb3 #bbd 7,aug47 #aiah4 ,9 ! treatm5t ( pneumonia1 ,rob]ts & ,c>y#d h employ$ a vacc9e made up ( #ajj million ( ea* ( ! foll[+ organisms p] cubic c5timet]3 influ5za bacilli1 pneumococci1 /aphylococci & /reptococci4 ,( ?is vacc9e !y inject$1 intrav5\sly1 fir/ #j4e c4c41 lat] #a c4c4 ,9 ! s]ies ( #bjj pati5ts s treat$ !re 0 no evid5ce ( injury to ! pati5ts 9 any way4 ,! mortality 9 ?is s]ies 0 #i4e p] c5t42 9 a s]ies ( eighty-six pati5ts n treat$ ) vacc9e1 ! mortality 0 #ca4b p] c5t4 ,9 ! untreat$ s]ies1 #bj p] c5t4 recov]$ by crisis2 9 ! treat$1 #cf p] c5t4 s recov]$4 ,be=e any reliance is plac$ on su* /ati/ics !y %\ld be analyz$ & comp>$ c>efully accord+ to age p]iods1 z ! dea? rate may v>y at diff]5t ages4 ,c[ie & ,beav5#bih us$ typhoid vacc9e 9 ! treatm5t ( _! pati5ts1 & !y consid] ! vacc9e %ock z indicat$ only 9 ! e>ly /ages ( pneumonia4 #bih ,report ( ,int]national ,heal? ,bo>d1 ,social ,m$ic9e1 ,m$ical ,economics & ,miscellany1 ,j4 ,a4 ,m4 ,a4 #gb3 #gea 7,m>* #h7 #aiai4 ,be=e apply+ ! treatm5t to su* diseases z pneumonia x w\ld seem t prud5ce w\ld dem& a ?or\gh famili>ity ) ! range ( ! reaction & ! degree ( toxicity ( ! prep>ation x is int5d$ to use by fir/ employ+ x 9 "s ar?ritic cases4 ,9 pneumonia we mu/ ev] keep be=e u ! vital factor ( c>diac impairm5t2 & c]ta9ly we mu/ n und]take any measure t may depress ! function ( ! he>t4 ,9 ar?ritis ?is dang] is l>gely a negligible "o2 &1 ) prop] precaution1 nonspecific !rapy is n only )\t risk b inde$ frequ5tly foll[$ by gratify+ cl9ical improvem5t4 ,only 9 ! light ( exp]i5ce ga9$ 9 ! mann] indicat$ w\ld x seem p]missible = u to attempt to ext5d ?is =m ( !rapy to m acute infections4--7,editorial f ,! ,j\rnal ,a4 ,m4 ,a41 ,may #ag1 #aiai47 ,,will>d ,,ealon ,,ogd5 ,a 8,speciali/ 9 ,proctology0 & ,8 8,cl9ics0 ,)9 ! pa/ few weeks a numb] ( inquiries h rea*$ ,! ,j\rnal f physicians 9 ,ohio1 ,indiana & ,p5nsylvania4 ,^? t foll[ are typical3 8,i am 9 receipt ( lit]ature f ,h4 ,l4 ,rob]ts1 #aabf ,masonic ,temple1 ,*icago1 adv]tis+ cl9ic 9 ,clevel& by ,dr4 ,will>d ,e4 ,ogd5 :o claims to be a memb] ( ! ,*icago ,m$ical ,society & ! ,a4 ,m4 ,a4 ,:at c y say ( ?is man & 8 me?ods80 8,i am enclos+ a fold] receiv$ a %ort "t ago4 ,i w\ld be glad to "k if ,dr4 ,ogd5 is a memb] ( ! ,a4 ,m4 ,a4 z he claims to be40 8,! enclos$ fold] has be5 s5t to _m doctors 9 ,indiana4 ,! purpose is pla94 ,! atta*$ po/ c>d on ?is "o 0 return$ to him = fur!r lit]ature40 ,illu/ration3 ,photographic reproduction ( "o ( ,ogd5 adv]tisem5ts 9 ,*icago newspap]s at ! "t he 0 at #cf ,w4 ,r&olph ,/reet4 ,9 ea* case ! correspond5ts s5d 9 a f\r-page fold] be>+ ! title 8,proctology1 ,a ,cl9ic4 ,:o8 ,:]e8 ,:y80 ,?ree ( ! f\r pages purport to answ] ! int]rogations giv5 on ! title page4 ,"u 8,:o80 we read3 ,,dr4 ,,will>d ,e4 ,,ogd5 ,*icago1 ,ill4 ,,speciali/ ,,9 ,,proctology ,memb] ,*icago ,m$ical ,society & ,a4 ,m4 ,a4 ,au?or ( 8,improv$ ,me?od ( ,treat+ ,rectal ,diseases0 ,=m]ly associat$ ) ,drs4 ,burleson ,burleson ,gr& ,rapids1 ,mi*4 ,"u ! "q 8,:]e80 !re appe>s ! /atem5t t 8,dr4 ,ogd5 ,w ,hold a ,cl9ic = ,! ,treatm5t ( ,rectal ,diseases0 & ! "n ( ! city & ! dates ( ! 8cl9ic0 are ins]t$ ) a typewrit]4 ,"u 8,:y80 we read3 8,dr4 ,ogd5 does n use ! usual surgical me?ods4 ,8 _m ye>s ( exp]i5ce 9 ! treatm5t ( ,rectal ,diseases 7dur+ :i* "t he has be5 associat$ ) ! lead+ ,proctologi/s ( ,am]ica7 h enabl$ him to develop a sy/em ( (fice treatm5t :i* is n taught by any o!r practition]4 8,te> (f1 sign & mail atta*$ po/c>d & ,i w s5d y a booklet giv+ y full p>ticul>s z to ! c\rse4 ,y\rs truly1 ,h4 ,l4 ,rob]ts1 ,bus9ess ,manag]4 8,eighty-?ree p] c5t4 ( ! p h "s ,rectal tr\ble4 ,,?is ,,is ,,! ,,day ,,( ,,speciali/s4 ,:y n fit y\rself to specialize 9 ,proctology80 ,! f\r? page is a po/ c>d address$ to 8,h4 ,l4 ,rob]ts1 ,room #aabf1 ,masonic ,temple1 ,*icago40 ,on ! rev]se side !re is a pr9t$ /atem5t :i* ! recipi5t is expect$ to sign to ! effect t he is int]e/$ 9 8,dr4 ,ogd5's ,cl9ic0 & wi%es to h 8full p>ticul>s ( ! c\rse40 ,a visit to ,room #aabf1 ,masonic ,temple1 fail$ to disclose ! "n ( ,h4 ,l4 ,rob]ts1 ei!r on ! door 7or doors1 = !re are two rooms hav+ ?is numb]7 or on ! (fice build+ directory bo>d4 ,9 fact1 ,rooms #aabf seem to conta9 a some:at miscellane\s assortm5t4 ,! signs1 ei!r on ! door or on ! directory bo>d1 %[ t !re is a public /5ograph] 7:o op]ates a 8,mail+ ,s]vice10 & does 8,address+1 ,mail+1 ,multigraph+1 ,mimeograph+071 a book/ore1 a *ocolate company1 a publi%+ company1 a lumb] company1 & "o or two o!r conc]ns2 b ! "n ( 8,h4 ,l4 ,rob]ts0 does n appe>4 ,incid5tally1 no 8,h4 ,l4 ,rob]ts0 is to be f\nd li/$ 9 ! ,*icago telephone directory4 ,a few y>ds away f ,rooms #aabf & on ! same floor !re appe>s ! "n1 8,dr4 ,will>d ,e4 ,ogd50 on ,room #aajb4 ,accord+ to our records1 ,will>d ,ealon ,ogd5 0 born 9 #ahff4 ,be=e tak+ up ! /udy ( m$ic9e he seems to h be5 a prea*]4 ,9 #ahii he 0 graduat$ by ! ,sag9aw ,valley ,m$ical ,college1 ,sag9aw1 ,mi*4 ,he 0 lic5s$ 9 ,mi*igan 9 #aijj1 9 ,ill9ois & ,indiana 9 #aiac1 & 9 ,wiscons9 9 #aiba4 ,f #aijj until #aijd he practic$ 9 ,lyons1 ,mi*42 f #aijf until #aiaa he 0 at ,ionia1 ,mi*4 ,9 #aiaa1 he 0 9 ,gr& ,rapids1 ,mi*41 & 0 associat$ ) ,burleson & ,burleson1 an adv]tis+ pile cure conc]n4 ,f "s ( ! volum9\s ,burleson adv]tis+ on file1 we le>n t !y 8cure all diseases ( ! rectum 7except canc]720 & claim to h 8! mo/ successful me?od ev] discov]$10 & to h cur$ 8_m desp]ate cases t h be5 giv5 up to die40 ,fur!rmore1 !y 8gu>antee to cure 9 e case or make no *>ge40 ,on ,jan4 #a1 #aiad1 ,ogd5 0 s5d+ out a c>d to physicians 9 :i* he /at$ t he _h remov$ f ,gr& ,rapids1 ,mi*41 & ,la,porte1 ,ind41 to #cf ,w4 ,r&olph ,/41 ,*icago1 & t he w\ld limit himself 8exclusively to ! treatm5t ( diseases ( ! rectum40 ,lat]1 ,ogd5 0 s5d+ out an adv]tis+ booklet fill$ ) te/imonials4 ,9 #aiad1 ,ogd5 0 c>ry+ display adv]tisem5ts 9 ,*icago pap]s read+1 9 "p1 9 l>ge back-fac$ type3 8,piles ,cur$ ,absolutely ,)\t ,knife1 ,ane/hetics1 ,pa9 or ,loss ( ,"t4444 ,cure ,gu>ante$ or ,money ,refund$40 ,9 ,m>*1 #aiah1 he became a memb] ( ! ,*icago ,m$ical ,society & qualifi$ = ,fell[%ip 9 ! ,am]ican ,m$ical ,association1 ,augu/1 #aiah4 ,9 #aiba1 ,ogd5 _h a copyright$ mail-ord] c\rse on ! 8,treatm5t ( ,rectal ,diseases by ,improv$ ,me?od40 ,?is 8c\rse0 consi/$ ( ?irty-eight pages ( foolscap pr9t$ on "o side 9 imitation typewrit+4 ,! mat]ial ab\nd$ 9 typographical errors4 ,among ! propriet>y products recomm5d$ 9 ?is 8c\rse0 z 8ess5tial0 to ^? tak+ x1 0 8,mecca ,o9tm5t40 ,?is no/rum1 made by a ,*icago conc]n1 0 decl>$ misbr&$ 9 #aiaf because ( false & fraudul5t claims made kn[+ly1 recklessly & wantonly4 ,! 8c\rse0 0 divid$ into t5 p>ts1 & ) x1 app>5tly1 came t5 consecutively numb]$ seal$ envelops1 & ! pur*as] 0 in/ruct$ to op5 ^! envelops1 "o at a "t1 z he complet$ ! correspond+ "p 9 ! 8c\rse40 ,he w\ld !re f9d que/ions :i* 7 to be answ]$ & return$ to ,ogd54 ,?is1 accord+ to ! description1 0 to enable ,ogd5 to det]m9e :e!r x 0 necess>y to 8ent] m into detail ^u t p>ticul> subject10 :i*1 he /at$1 he w\ld gladly d if necess>y4 ,illu/ration3 ,photographic reproduction 7r$uc$7 ( ! fir/ page ( a booklet ,ogd5 0 s5d+ out 9 ! latt] "p ( #aiad4 ,fur!rmore1 ! pur*as] _h ! privilege ( ask+ que/ions ( ,ogd5 relative to symptoms1 diagnosis & treatm5t = a p]iod ( six mon?s aft] ! pur*ase ( ! 8c\rse40 ,al?\gh1 9 ,ogd5's op9ion1 8y %\ld h ! subject well und]/ood long be=e t "t40 ,! *>ge = ?is c\rse & 8s]vices z outl9$0 0 #bjj1 b 9 ord] to %[ 8 confid5ce 9 ! ability ( ^? :o pur*as$ x1 ,ogd5 0 will+ to take #ajj d[n & ! o!r #ajj paid 9 8five p] c5t4 ( monies receiv$ f ,,cur$ pati5ts0 until ! balance 0 paid4 ,rev]t+ to ! pres5t 8po/-graduate c\rse0 & 8cl9ic03 ,^? :o s5d 9 ! po/al c>d to 8,h4 ,l4 ,rob]ts0 receive a =m-lett]1 sign$ 8,h4 ,l4 ,rob]ts0 9 facsimile h&writ+1 /at+ t in=mation 0 enclos$ 8reg>d+ ,,! ,,ogd5 ,,me?ods0 & /at+ t ,dr4 ,ogd5 w\ld be 9 ,indianapolis or ,clevel& or ,pittsburgh1 z ! case might be1 on a c]ta9 date & t ! fee = ! 8cl9ic0 w\ld be #ajj4 ,) ?is lett] is an eight-page pamphlet entitl$ 8,"s ,facts ,conc]n+ ! ,ogd5 ,me?od ( ,treat+ ,rectal ,diseases40 ,! fir/ page is head$ 9 black-fac$ type3 8,ab\t ,ref]5ces & ,endorsem5ts40 ,x !n /ates t ! 8usual ref]5ces & endorsem5ts are omitt$ f ?is booklet40 ,fur!r3 8,z to ,dr4 ,will>d ,e4 ,ogd53 ,! pr(essional & social /&+ ( ,dr4 ,ogd5 is su* t he does n ne$ to (f] any4 8,z to #8,,! ,,ogd5 ,,me?od' & its value to y 9 y\r pr(essional "w3 ,:at o!rs say or ?9k has little if any weight4 ,y are y\r own man4 ,y d y\r own ?9k+4 ,y decide = y\rself--,d y n80 ,illu/ration3 ,photographic reproduction 7greatly r$uc$7 ( an adv]tisem5t ( ! ,burleson conc]n ) :i* ,ogd5 0 connect$ previ\s to #aiad1 & :i* connection he is capitaliz+ 9 8 pres5t adv]tis+4 ,! booklet gives an outl9e ( ! 8,c\rse ( ,in/ruction10 :i* is almo/ id5tical1 ^w = ^w1 ) ! outl9e giv5 9 ! lett] adv]tis+ ! mail-ord] c\rse previ\sly ref]r$ to4 ,! booklet fur!r /ates t 8,,! ,,ogd5 ,,me?od has entirely elim9at$ ! use ( caut]y1 ! ligature or any injections1 9 ! treatm5t ( hemorrhoids10 b t 8! use ( ! electric curr5t has prov$ to be ! v correct me?od 9 su* cases1 z w be demon/rat$ at ! cl9ic40 ,! booklet reit]ates ! /atem5t t ,ogd5's association ) ! ,burleson & ,burleson conc]n at ,gr& ,rapids makes him 8em95tly well qualifi$ to in/ruct memb]s ( ! m$ical pr(ession 9 ?is important bran* ( ! m$ical sci5ce60 ,9 addition to ?is booklet !re is a f\r-page adv]tis+ leaflet illu/rat+ & describ+ ! 8,ogd5 ,rectal ,cab9et0 & also ! 8,ogd5 ,rectal ,table & ,/ool40 ,!re is also a little po/c>d--address$1 ( c\rse1 to 8,h4 ,l4 ,rob]ts0--= ! physician to fill 9 /at+ t 8y may enroll me z int5d+ to att5d ,dr4 ,ogd5's ,cl9ic 9 ,proctology1 to be held at----40 ,%\ld ! recipi5t n fill 9 & mail ?is enrolm5t c>d he gets ano!r =m lett] call+ att5tion to ! fact t ! enrolm5t c>d has n be5 receiv$ & /at+ fur!r t 8available hotel facilities make x necess>y to limit our enrolm5t to tw5ty /ud5ts40 ,c>eful se>* fails to disclose t ,dr4 ,will>d ,ealon ,ogd5 has ev] di/+ui%$ himself 9 ! practice ( ! specialty 9 :i* he n[ wi%es to in/ruct physicians4 ,equally c>eful se>* fails to %[ t ,dr4 ,ogd5 has ev] publi%$ a pap] ei!r on any proctologic subjects or on any o!r phase ( m$ic9e or surg]y4 ,nei!r does !re seem to be any evid5ce = ! claim t ,dr4 ,ogd5 8has be5 associat$ ) ! lead+ ,proctologi/s ( ,am]ica40--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,feb4 #d1 #aibb47 8,,pat5ts0 ,pat5t ,laws & ,pat5t ,(fice ,practice ,! inequity ( our pat5t laws1 or possibly x w\ld be m correct to say1 ( ! int]pretation ( our pat5t laws1 has be5 comm5t$ on _m times 9 ,! ,j\rnal4 ,! ,j\rnal also has _h occasion to call att5tion to pat5ts t h be5 issu$ = obvi\sly unsci5tific & quacki% devices & prep>ations4 ,! cases ( ! prepo/]\s gas-pipe fake 8,oxydonor0 & ! creat99 mixture = ! alleg$ conf]r+ ( immunity aga9/ diph!ria1 pneumonia1 sc>let fev]1 syphilis1 tub]culosis1 etc41 are cases 9 po9t4 ,9 a pat5t issu$ ! e>ly "p ( ?is ye> = ! 8discov]y0 ( a me?od ( flavor+ ,epsom salt1 ! pat5t (fice has1 9 fatuity1 pil$ ,pelion on ,ossa4 ,! 8inv5tor0 decl>es t 8 inv5tion relates to a ph>maceutical prep>ation & a special me?od ( treatm5t ( ! m$ic9al ag5ts :]eby said ag5t w be r5d]$ mu* m effici5t 9 "*4 ,he fur!r av[s t ! 8prime object0 ( 8 8inv5tion0 is to 8disguise ! normal ta/e & imp>t an agreeable odor or smell to salts commonly employ$ z a ca?>tic40 ,p>5!tically x may be said t probably n a day passes t "s physician 9 ! ,unit$ ,/ates does n d sub/antially ! same ?+ :5 writ+ a prescription4 ,! 8inv5tor0 fur!r claims t ! object ( 8 8inv5tion0 is to utilize ! salts z a vehicle to c>ry an antiseptic & ane/hetic ag5t :]eby ! salts :5 adm9i/]$ z a ca?>tic 8w also act b5eficially on ! entire dige/ive tract0 & 8:]eby cramp$ & spasmodic conditions are at once reliev$ ) a result+ cure ( flatul5cy1 indige/ion1 sick & s\r /oma*1 colic & ! de/ruction ( worms1 etc40 ,su* claims are s absurd t ! only excuse = comm5t+ on !m is ! effect !y h on ! public m9d4 ,! layman read+ ! specifications ( ?is pat5t w\ld naturally conclude t an inv5tion ( great importance _h be5 made--( su* importance z to w>rant ! gov]nm5t 9 rew>d+ its inv5tor by grant+ him a sev5te5-ye> monopoly on ! sale ( 8 inv5tion4 ,! law requires t1 to be pat5table1 inv5tions %all be new & useful & %all %[ a high] degree ( skill 9 _! inception ?an is naturally to be expect$ f ^? :o are skill$ 9 ! arts to :i* ! inv5tions belong4 ,x has be5 decid$ aga9 & aga9 t physicians' prescriptions are n pat5table because x is assum$ t an educat$ physician w utilize 8 k ( ph>macy 9 devis+ prop] comp\nds ( m$ic9es to meet ! indications ( disease4 ,:5 a physician prescribes a dose ( ,epsom salt to be tak5 9 "o ( ! (ficial aromatic wat]s1 he does n produce or create a new inv5tion by s do+4 ,( c\rse1 9 "o s5se e prescription is an inv5tion--an inv5tion to meet ! conditions pres5t$ by ! pati5t--b su* inv5tions are n pat5table1 because !y repres5t ! ord9>y skill ( a physician 9 c>ry+ on 8 vocation4 ,if ! pat5t (fice goes on grant+ pat5ts = su* 8inv5tions0 z flavor$ ,epsom salt1 & x %\ld be f\nd f9ancially pr(itable to secure su* pat5ts & place ! products on ! m>ket1 x w only be a matt] ( "t be=e ! mat]ia m$ica w be s re/rict$ t a physician w be unable to write a prescription )\t infr++ on somebody's pat5t4 ,! spl5did conception ( ! fram]s ( our con/itution 9 provid+ a plan = promot+ progress 9 sci5ce & useful arts by grant+ to inv5tors = a limit$ "t ! exclusive use ( _! inv5tions1 9 ex*ange = ! publication ( full k !re(1 is be+ debas$4 ,no bran* ( our gov]nm5t is ( great] importance to ! progress ( ! c\ntry ?an ! pat5t (fice1 provid$ t (fice is intellig5tly adm9i/]$4 ,:5 ! pat5t (fice is us$1 h[ev]1 = an ext5tion ( ! no/rum bus9ess1 f\nd$ on ! abuse ( pat5t & trade-m>k laws1 x becomes a m5ace to ! public heal?4 ,! objects ( ! pat5t law are be+ defeat$ by ! practices ( ! pat5t (fice4--7,editorial f ,! ,j\rnal ,a4 ,m4 ,a41 ,june #bc1 #aiag47 ,our ,ar*aic ,pat5t ,laws ,9 ?is issue we publi% two reports ( ! ,c\ncil on ,ph>macy & ,*emi/ry :i* illu/rate ! weaknesses ( ! pres5t work+ ( ! ,unit$ ,/ates pat5t laws4 ,9 ! fir/ report ! ,c\ncil pres5ts an inve/igation ( a rec5tly grant$ pat5t1 & %[s t ! pat5t 0 issu$ on ! m]e claims ( ! applicant & )\t ! pres5tation ( any evid5ce = su* claims4 ,! second report--8,ne$ = ,pat5t ,law ,revision0--is an appeal to ! ,pat5t ,(fice = a m enlight5$ adm9i/ration ( ! pat5t law1 & x pres5ts a few illu/rations ( ! unfair protection :i* has be5 grant$ by ! ,pat5t ,(fice4 ,! prote/ ( ! ,c\ncil appe>s at an opportune "t4 ,9 ,sci5ce#bii ! 8,pat5t ,(fice ,society10 an association ( employees ( ! ,u4 ,s4 ,pat5t ,(fice1 ann\nces t a committee has be5 creat$ on reque/ ( ! ,national ,rese>* ,c\ncil to make a /udy ( ! ,u4 ,s4 ,pat5t ,(fice & its s]vice to sci5ce & arts4 ,x /ates t ?is committee w meet 9 ,wa%+ton %ortly to consid] ! adequacy ( ! pres5t ,pat5t ,(fice equipm5t & ! simplification ( proc$ure z well z responsiv5ess to pres5t national & int]national requirem5ts4 ,! committee also hopes to coord9ate1 9 ! int]e/ ( an improv$ public s]vice1 ! endeavors ( ! v>i\s national societies1 manufactur+ int]e/s1 pat5t b> associations & all o!rs aim+ at g5u9e pat5t re=m4 ,unque/ionably1 !re is a gr[+ conviction t 9 ! case ( m$ic9es ! monopoly giv5 by ! pat5t laws1 if grant$ at all1 %\ld be grant$ ) great] consid]ation ( ! public welf>e4 ,too (t5 ! ,unit$ ,/ates ,pat5t ,law has be5 us$ to obta9 an unfair monopoly on a m$icam5t or to abet quack]y4 ,!re is no "q t "o ( two ?+s is ne$$3 ei!r a radical *ange 9 ! pat5t law itself or ! application ( m bra9s 9 its adm9i/ration4--7,editorial f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #ab1 #aiah47 #bii ,dec4 #bh1 #aiag1 p4 #fbi4 ,pat5ts ,p]petuat$ by ,trade ,names ,! pat5t on aspir9#cjj 7acetylsalicylic acid71 controll$ by ! ,bay] ,company1 ,am]ican repres5tative ( ! ,f>b5fabrik5 ( ,elb]feld ,company1 w expire next ye> 7#aiag74 ,! ,j\rnal has previ\sly /at$ t ! grant ( ?is pat5t 0 regrettable & work$ inju/ice to ,am]ican citiz5s4 ,x is unnecess>y aga9 to g into ! gr\nds = ?is /atem5t2 nei!r 9 ! ,f>b5fabrik5's home c\ntry1 ,g]many1 nor 9 any o!r c\ntry except 9 ! ,unit$ ,/ates1 has a pat5t be5 grant$ = ?is product4 ,ow+ to _! monopoly1 ! manufactur]s h be5 able to exact a mu* high] price = acetylsalicylic acid1 or aspir91 9 ?is c\ntry1 ?an else:]e4 ,naturally1 ! ,bay] ,company1 ! ,am]ican ag5ts1 view ) disfavor ! prospect ( be+ compell$ to %>e ?is ri* field ) competitors4 ,! =ego+ furni%es ! answ] to inquiries :i* h rea*$ u f all ov] ! c\ntry ) reg>d to ! campaign ( publicity :i* ! ,bay] ,company has inaugurat$ 9 ! lay press4 ,a presumably au!ntic & app>5tly c&id exposition ( ! me?ods us$ & ! motives beh9d ! aspir9 adv]tis+ is furni%$ 9 ,pr9t]s' ,ink3#cja #cjj ,grant$ ,feb4 #bg1 #aijj4 #cja ,pr9t]s' ,ink1 ,june #bi1 #aiaf1 p4 #ahi2 ,july #ac1 #aiaf1 p4 #ajj4 8,! manufactur]s ( aspir9 are ab\t to laun* an ext5sive adv]tis+ campaign to cl9* ! m>ket z f> z possible be=e ! expiration ( _! pat5t rights next ye>4444 ,! purpose ( ! campaign is to id5tify ! product ) ! tradem>k ( ! ,bay] ,company & to ?is ext5t hamp] competition aft] ! expiration ( ! pat5t40 ,! bus9ess ( ! ,bay] ,company1 ! article goes on to say1 has be5 hurt by ! sale ( wor?less or ev5 h>mful imitations put on ! m>ket by irresponsible & unau?oriz$ p]sons :5 ! pres5t w> /opp$ importations f ,g]many4 8,! public knew aspir91 b did n "k :o made x italics ours4444 ,:5 ! ,bay] ,company1 ,inc41 took ov] ! manufacture ( aspir9 9 ?is c\ntry1 ! fir/ /eps 7 tak5 to id5tify ! product ) ! firm :o made x4444 ,( c\rse1 !re are good reasons :y ! mak]s 7 lo? to adv]tise ! product or to exploit _! tradem>k4 ,z e "o kn[s1 ! adv]tis+ ( a m$ical proposition is an extremely tickli% subject4444 ,x is easy to make a mis/ep4 ,aspir9 is "o ( ^? propriet>y drugs t are ext5sively prescrib$ by physicians4 ,if any?+ 7 done t might possibly associate ?is drug ) ! pat5t m$ic9es t are 9 disfavor ) ! pr(ession1 ! valuable influ5ce & coop]ation ( ?\s&s ( doctors might be lo/4 ,x is believ$ t ?is knotty phase ( ! "q is be+ answ]$ 9 ! pres5t adv]tis+4444 ,s9ce no?+ is m5tion$ ab\t #8m$ic9e1' #8cures' or #8ailm5ts1' x is anticipat$ t !re w be b little objection to ! copy4 ,all t ! adv]tis+ attempts to d is to l9k up ! "n #8,bay]' ) aspir94444 ,! ne>e/ ! copy gets to m$ical talk is 9 ?is s5t5ce 9 v small type at ! bottom ( ! adv]tisem5t1 #8,! tradem>k 8,aspir90 7,reg4 ,u4 ,s4 ,pat5t ,(fice7 is a gu>antee t ! monoacetic acid e/] ( salicylic acid 9 ^! tablets is ( ! reliable ,bay] manufacture4'0 ,f ?is x appe>s t1 n cont5t ) sev5te5 ye>s ( monopoly1 ! aspir9 p are attempt+ to reta9 a hold on ! m>ket 9 p]petuo by associat+ ! "n ( ! company ) ! trade "n 8aspir940 ,!re c be no bett] "t ?an ! pres5t1 !re=e1 = ! m$ical pr(ession to sub/itute1 = ! nondescriptive "n 8aspir910 ! descriptive & correct "n acetylsalicylic acid4--7,editorial f ,! ,j\rnal ,a4 ,m4 ,a41 ,aug4 #ab1 #aiaf47 ,pat5t+ ,!rapeutic ,ag5ts ,9 ! pa/1 !rapeutic ag5ts & app>atus h be5 controll$ by pat5ts & tradem>ks = pr(it4 ,if !re h be5 exceptions1 !y h be5 r>e4 ,! ,pr9ciples ( ,m$ical ,e?ics ( ! ,am]ican ,m$ical ,association conta9 ?is /atem5t3 8,x is unpr(essional to receive remun]ation f pat5ts = surgical in/rum5ts or m$ic9es40 ,?is does n mean t ! pat5t+ is wrong 9 itself2 !re are occasions :5 x is wise1 if n necess>y1 to obta9 a pat5t 9 ! int]e/ ( ! public1 &1 9 ! case ( surgical in/rum5ts & m$ic9es1 ( ! m$ical pr(ession4 ,9 c]ta9 in/ances x is absolutely necess>y t ! article produc$ %all ma9ta9 a def9ite /&>d ( quality & purity--&1 x may be add$1 %all be sold at a reasonable price4 ,ent]pris+ ph>maceutical manufactur]s h usually be5 ready to appropriate ! results ( sci5tific rese>* by inve/igators or !rapeutic measures sugge/$ by practic+ physicians4 ,n infrequ5tly1 9 su* in/ances1 ! desire = f9ancial ga9 has caus$ ! m>ket+ ( su* products ) extravagant1 if n false1 claims z to _! value4 ,yet ! pat5t laws may be us$ s z to protect & b5efit ! public & ! m$ical pr(ession4 ,9 rese>* laboratories1 "w is be+ c>ri$ on result+ 9 ! production ( new !rapeutic ag5ts4 ,x is important t ^! ag5ts %all be s controll$ t !y may be made available )\t subord9ation to comm]cial int]e/s4 ,x has become practically necess>y1 !re=e1 = rese>* work]s to protect _! products 9 ! int]e/ ( ! public welf>e & sci5tific m$ic9e4 ,x has n be5 an easy matt] to decide h[ be/ to br+ ab\t ! desir$ results4 ,?is "q has be5 be=e ! ,bo>d ( ,tru/ees ( ! ,am]ican ,m$ical ,association2 &1 9 #aiad1 ! ,h\se ( ,delegates pass$ a resolution au?oriz+ ! bo>d to accept at its discretion pat5ts = m$ical & surgical in/rum5ts & appliances2 z tru/ees1 = ! b5efit ( ! pr(ession & ! public1 provid$ t nei!r ! ,association nor ! pat5tee %\ld receive remun]ation f ^! pat5ts4 ,! ,rockefell] ,in/itute = ,m$ical ,rese>* has solv$ ! problem 9 a simil> mann]4 ,9 connection ) ! report ( ! discov]y ( sev]al new ars5ic comp\nds1 ,jacobs & ,heidelb]g]1#cjb work+ 9 ! ,rockefell] ,in/itute1 say3 #cjb ,jacobs1 ,w4 ,a41 & ,heidelb]g]1 ,m43 ,aromatic ,ars5ic ,comp\nds1 ,,ii1 ,! ,amides & ,alkyl ,amides ( ,n--,arylglyc9e ,arsonic ,acids1 ,j4 ,am4 ,*em4 ,soc4 #da3aehg 7,oct47 #aiai4 ,x may be appropriate to m5tion "h t ?is sub/ance & relat$ comp\nds1 describ$ 9 ! pres5t & foll[+ pap]s ( ! s]ies1 are cov]$ by ,u4 ,s4 ,pat5ts ,nos4 #abhjaai-bg4 ,pat5ts h also be5 appli$ = 9 =eign c\ntries4 ,all discov]ies made at ! ,rockefell] ,in/itute are made freely available to ! public1 9 accordance ) ! philan?ropic purposes ( ! in/itution4 ,9 ord] to insure purity ( product & protection aga9/ exploitation1 x has be5 deem$ necess>y 9 c]ta9 in/ances to protect ! discov]ies by pat5ts4 ,x is ! purpose ( ! in/itute to p]mit any drugs :i* may prove ( practical !rapeutic value to be manufactur$ "u lic5se by suitable *emical firms & "u conditions ( production :i* w insure ! biological qualities ( ! drugs & _! m>ket+ at reasonable prices4 ,o!r ?an ?r\gh ! issuance ( lic5se1 ! ,rockefell] ,in/itute does n p>ticipate 9 any way 9 ! comm]cial prep>ation or sale ( ! manufactur$ *emicals2 & x receives no royalties or o!r pecuni>y b5efits f ! lic5ses x issues4 ,"h we h m$ic9e at its be/4 ,! altruism ( pure sci5ce op]at+ = ! b5efit ( ! g5]al public3 sci5tific !rapeutics fre$ f comm]cial dom9ation4--7,editorial f ,! ,j\rnal ,a4 ,m4 ,a41 ,oct4 #ah1 #aiai47 ,,ph>maceutical ,,b>nums ,does ! public love to be humbugg$8 ,we d\bt x4 ,t we1 :e!r sage or fool1 are humbugg$ is und5iable4 ,we are humbugg$ j to ! ext5t t we are ignorant4 ,!re lies "o ( ! mo/ p[]ful factors op]at+ to ! advantage ( ! 8pat5t m$ic9e0 mak] & ! quack4 ,! layman's ignorance ( ! possibilities & limitations ( drugs is wide & deep4 ,h5ce ! ease ) :i* he is fool$ on ?is subject4 ,a seem+ frankness 9 adv]tis+ be+ ! ord] ( ! day1 ! no/rum mak] makes a pret5se ( tell+ :at is 9 8 /uff )\t disclos+ any facts t w t5d to lift ! veil ( my/]y & ?us de/roy 8 greate/ asset4 ,s ! exploit] ( no/rums to ! m$ical pr(ession1 realiz+ t at lea/ a pret5se mu/ be made ( giv+ ! composition ( m$icam5ts (f]$ to ! physician1 decl>es t 8 clay p\ltice has = its base 8anhydr\s & levigat$ argillace\s m9]al40 ,?is s\nds mu* m impos+ ?an dry & f9ely p[d]$ clay1 & satisfies by its v sonor\sness4 ,n[ comes a product exploit$ *iefly to memb]s ( ! d5tal pr(ession b also1 x seems1 to physicians4 ,tablets1 8activat$ tablets10 if y please6 ,!y are 8an anodyne1 analgesic febrifuge s$ative1 exorcis+ sic6 ant9euralgic & antirheumatic action40 ,& _! composition8 ,simply 8an activat$1 balanc$ comb9ation ( ! mono-acetyl-d]ivative ( p>a-amidoph5etol toge!r ) a feebly basic sub/ance 9 ! alkaloidal /ate f ! ,!a-,s95sis40 ,z cle> z ! ,miss\ri ,riv]6 ,"s day "s d5ti/ or physician is go+ to inve/igate & f9d t ?is awe-inspir+1 polysyllabic example ( exub]ant v]bosity means no?+ m my/]i\s ?an our old fri5ds acetph5etid9 7ph5acet97 & caffe94 ,9 ! meantime1 ! exploit]s may smile s(tly & murmur1 8,b>num 0 "r60--7,editorial f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #a1 #aiba47 ,,! ,,ph>macopeia ,! ,n9? ,dec5nial ,revision ,! n9? revision ( ! ,unit$ ,/ates ,ph>macopeia became (ficial ?is week1 ,sept4 #a1 #aiaf4 ,x is m fully review$ else:]e2#cjc "h we desire m]ely to call att5tion to two po9ts2 :at ! book is & :at x is n4 ,x is a book ( /&>ds = drugs2 x is n a book ( /&>d rem$ies4 ,! ,committee ( ,revision ( ! ,ph>macopeia includ$ physicians & ph>maci/s 7retail1 :olesale & manufactur+71 b ! ph>maci/s 7 9 ! majority & 9 control4 ,! majority ( ! repres5tatives ( ! m$ical pr(ession on ?is committee w\ld h pref]r$ to see ! bulk ( ! ,ph>macopeia r$uc$ & its value z a "w ( ref]5ce enhanc$ by ! rejection ( !rapeutically wor?less drugs4 ,! repres5tatives ( comm]cial int]e/s1 on ! o!r h&1 argu$ t x 0 necess>y = ! ,ph>macopeia to provide /&>ds = drugs 9 m or less g5]al use1 :e!r wor?less or o!rwise4 ,! =ce ( ?is argum5t is some:at impair$ by ! fact t ! ,national ,=mul>y1 :i* has also be5 made a book ( legal /&>ds1 n[ includes individual drugs z well z comb9ations2 ! new edition ( ! ,=mul>y1 9 fact1 conta9s a l>ge numb] ( drugs :i* _h be5 dropp$ f ! ,u4 ,s4 ,ph>macopeia ,,viii4 ,! pr9ciple ( mak+ use ! sole crit]ion = admission to ! ,ph>macopeia1 h[ev]1 on ! :ole c>ri$ ! day4 ,x has n be5 /rictly obs]v$2 good results f ! ef=ts ( ! m$ical cont+5t are to be obs]v$ "h & !re1 z 9 ! deletion ( elixir ( ! phosphates ( iron1 qu99 & /ry*n9 & ( emulsion ( cod liv] oil ) hypophosphites4 ,t ^! in/ances 7 n expressions ( policy on ! "p ( ! ,committee on ,revision1 b m]ely deviations f policy1 may be se5 by a glance at ! cont5ts ( ! new ,ph>macopeia4 ,^! include sub/ances :i* h be5 %[n to be in]t1 l ! hypophosphites 7calcium1 potassium & sodium hypophosphites71 complex & obsolete mixtures1 l ! comp\nd syrup ( s>sap>illa1 & drugs :i* h be5 tri$ & f\nd want+1 l saw palmetto b]ries4 ,ev5 sub/ances seldom us$ by ! m$ical pr(ession1 b *iefly or altoge!r by ! public1 l sassafras1 hops & pepp]m9t 7! h]b71 are /&>diz$ & made (ficial4 ,x seems difficult to discov] any pr9ciple by :i* ! sph]e ( ! ,ph>macopeia may be def9itely m>k$ (f f t ( ! ,national ,=mul>y4 ,!re is "o great advantage 9 specify+ ,u4 ,s4 ,p4 drugs & prep>ations3 ,physicians :o d s invoke legal /&>ds ( purity & id5tity4 ,! only way to be sure ( obta9+ sub/ances ( !rapeutic effici5cy1 h[ev]1 is to ex]cise discrim9ation4 ,! ,ph>macopeia is no guide4 ,be+ prep>$ ma9ly by ph>maci/s to meet ! ne$s ( ph>maci/s1 ! ,ph>macopeia ( c\rse conta9s mu* matt] ( little int]e/ to physicians & entirely =eign to sci5tific m$ic9e4--7,editorial f ,! ,j\rnal ,a4 ,m4 ,a41 ,sept4 #b1 #aiaf47 #cjc ,j4 ,a4 ,m4 ,a4 #fg3gfd 7,sept4 #b7 #aiaf4 ,review ( ,n9? ,revision ,! n9? revision ( ! ,unit$ ,/ates ,ph>macopeia1 :i* has be5 9 ! h&s ( ! ,committee ( ,revision = m ?an six ye>s1 has j appe>$4 ,z 0 to be expect$1 ! desire ( m$ical m5 on ! ,committee ( ,revision to h !rapeutic value made a requirem5t = admission to ! ,ph>macopeia has n be5 fully realiz$2 x rema9s a book ( /&>ds = !rapeutically good1 bad & indiff]5t rem$ies4 ,among ! drugs ( little or no !rapeutic importance or value are musk1 arnica1 eriodictyon1 quassia1 pumpk9 se$1 saw palmetto b]ries1 s>sap>illa & c\* grass4 ,_m sup]flu\s drugs & prep>ations are includ$4 ,= in/ance1 ( ! n9e =ms ( qu99 describ$ 7qu99 alkaloid1 bisulphate1 dihydro*lorid1 hydrobromid1 hydro*lorid1 salicylate1 sulphate & tannate1 & qu99 & urea hydro*lorid71 at lea/ f\r might well h be5 elim9at$4 ,two insoluble =ms 7! alkaloid & ! tannate71 two soluble =ms 7! hydro*lorid & qu99 & urea hydro*lorid71 & a mod]ately soluble =m 7! sulphate7 are all t c\ld reasonably be dem&$ by ev5 ! mo/ extreme p>tisans ( ! doctr9e ( 8ph>maceutic necessity40 ,fur!r1 ! use ( qu99 salicylate = its salicylic acid cont5t & ( qu99 hydrobromid = its bromid cont5t is unsci5tific4 ,! inclusion ( ^! salts 9 ! ,ph>macopeia is regrettable4 ,^? int]e/$ 9 ! promotion ( rational !rapy w also regret ! inclusion ( a numb] ( fluidextracts ( viol5tly toxic drugs1 su* z aconite & gelsemium 7dose #a_/b m9im ea*71 belladonna root1 digitalis1 nux vomica & ipecac 7dose #a m9im ea*71 & lobelia 7dose #b-a_/b m9ims74 ,! m dilut$ =ms1 ! t9ctures1 ( ^! drugs are pref]able4 ,! inclusion ( su* fluidextracts 9 ! ,ph>macopeia is play+ into ! h&s ( c]ta9 ph>maceutical manufactur]s1 :o recomm5d ! t9cture be prep>$ f fluidextracts--an unsci5tific proc$ure4 ,! ef=ts ( ! m$ical memb]s ( ! committee1 h[ev]1 h n be5 entirely fruitless4 ,( ! articles describ$ 9 ! ,u4 ,s4 ,ph>macopeia ,,viii1 #bdc h be5 delet$2 sixty-sev5 new articles h be5 add$4 ,! loss ( #afg titles may be set d[n z a ga94 ,moreov]1 mo/ ( ! new sub/ances give promise ( !rapeutic usefulness4 ,?irty-six are tak5 ov] f ,new & ,non(ficial ,rem$ies2 n9ete5 are sub/ances :i* are 9 ! edition ( ,useful ,drugs n[ 9 ! press4 ,x _c be said1 h[ev]2 t all ( ! additions h be5 judici\sly select$4 ,x is an infelicit\s "t to add calcium & sodium glyc]ophosphate j :5 grave d\bts ( _! !rapeutic effici5cy are be+ felt4 ,! addition ( ! extracts ( aconite1 hydra/is & viburnum prunifolium is likewise un=tunate4 ,all are sup]flu\s prep>ations1 ! fir/ because a drug s p[]ful t an av]age dose ( ! extract is only #aj mg4 or #a_/f gra9 is bett] giv5 9 ! =m ( t9cture2 ! second because hydra/is is a drug ( unc]ta9 value1 already repres5t$ by ?ree prep>ations1 & ! ?ird because viburnum prunifolium has be5 disc>d$ & discr$it$ by ! be/ !rapeutic au?orities4 ,x mu/ be acc\nt$ cle> ga91 on ! o!r h&1 t ! deletions include _m in]t1 obsolete or sup]flu\s sub/ances l bismu? citrate1 kaol9 cataplasm1 pipsissewa1 coca leaves1 ladyslipp]1 wahoo1 cotton root b>k1 comp\nd acetanilid p[d] & comp\nd syrup ( hypophosphites1 n to m5tion n9e salts ( iron & ?irty-eight fluidextracts ( v>i\s drugs4 ,w9es1 unm$icat$ & m$icat$1 :isky & br&y are also among ! articles dropp$4 ,a numb] ( new features are introduc$1 su* z microscopic /&>ds = p[d]$ drugs1 /&>d abbreviations = titles1 ! use ( ! t]m 8mil0 in/ead ( 8cubic c5timet]10 & a *apt] ea* on /]ilization1 diagno/ic reag5ts1 biologic assays1 electrolytic det]m9ation ( metals & ! det]m9ation ( alcohol1 ! melt+ po9t1 ! boil+ po9t & ! congeal+ po9t4 ,! *emical nom5clature is sub/antially ! same z t adopt$ 9 ! previ\s revision2 s is ! nom5clature ( drugs4 ,! addition ( (ficial abbreviations = ! ,lat9 titles ( drugs w d\btless be f\nd a useful feature4 ,less comm5dable is ! *ange f ! famili> 8,cc40 to 8mil40 ,! t]m 8cubic c5timet]0 is s ?or\ghly e/abli%$ & s widely us$1 :]ev] ! metric sy/em is employ$1 t x _c be expect$ t x w be univ]sally displac$ by ! ^w 8mil40 ,! latt] is !re=e only a sup]flu\s synonym1 & z su* out ( h>mony ) ! simplicity ( ! metric sy/em4 ,p]haps x may ev5 be tak5 = ! abbreviation ( 8millimet]10 8milligram0 or o!r words d]iv$ f 8mille10 :i* w\ld be equally entitl$ to ! same abbreviation4--7,book ,review 9 ,! ,j\rnal ,a4 ,m4 ,a41 ,sept4 #b1 #aiaf47 ,,physician',s ,,/ock ,,9 ,,prescription ,,products ,! lett] t foll[s comes f a physician :o feels t he has a grievance reg>d+ a company 9 :i* he holds /ock3 8,9 #aiad1 ,i b\ght "s /ock ( ! ---- ---- ,company1 & 9 #aiag b\ght "s m /ock 9 ! same company4 ,i notice t ! company adv]tises 9 ,! ,j\rnal ( ! ,am]ican ,m$ical ,association1 & ,i believe x does ?is n s mu* to acqua9t ! m$ical pr(ession ) its product1 z to acqua9t physicians ) its "n 9 ord] t its /ock salesm5 c keep on unload+ m /ock to memb]s ( ! m$ical pr(ession4 8,! company gets ! doctors' money ?r\gh ! sale ( /ocks1 x gets its product on ! m>ket ) ! doctors' assi/ance & ?r\gh _! influ5ce1 & x looks to me z if ! doctors 7 gett+ v little 9 return1 z ! divid5d *ecks h be5 few & f> betwe5 s9ce ,i h kn[n any?+ ( ! company4 8,x is n my idea to criticize ! product2 b ,i d believe & feel t ! /ockhold]s are entitl$ to a squ>e deal f a company :i* 9 turn is expect+ s mu* f !m1 & aga9 ,i feel t ! publi%]s ( ,! ,j\rnal %\ld be made aw>e ( ^! conditions s t !y d n ei!r consci\sly or unconsci\sly fo/] a conc]n t is depriv+ ! physician ( 8 h>d-e>n$ money4 8,if ?is lett] is unfair1 ,i am will+ to be %[n o!rwise4 ,k9dly publi% x 9 ,! ,j\rnal1 omitt+ my "n & address40 ,! company to :i* our correspond5t ref]s put out a propriet>y product prescrib$ by physicians & us$ by ! public4 ,"s ye>s ago ! company 9 "q adv]tis$ its product 9 ,! ,j\rnal until its /ock-sell+ s*eme 0 br\ght to ! att5tion ( ,! ,j\rnal2 ! adv]tisem5ts 7 !n reject$4 ,"s ye>s lat]1 on evid5ce t ! company _h discont9u$ its /ock-sell+ me?ods to physicians1 its product 0 aga9 admitt$ to ! adv]tis+ pages ( ,! ,j\rnal4 ,our correspond5t says t he believes t ! physicians :o hold /ock 9 ?is company 8are entitl$ to a squ>e deal40 ,:at ab\t ! public8 ,is x gett+ a squ>e deal :5 physicians are f9ancially int]e/$ 9 ! products t !y may be call$ on to prescribe8 ,is ! av]age layman's confid5ce 9 ! m$ical pr(ession likely to be enhanc$ :5 he le>ns t ! physician to :om he w5t = treatm5t has a f9ancial int]e/ 9 ! !rapeutic ag5t :i* 0 prescrib$8 ,our correspond5t's compla9t aga9/ ! company seems to be1 n t ! company sold /ock to physicians1 b t 8! divid5d *ecks h be5 few & f> betwe510 ! assumption be+ t _h ! divid5ds come regul>ly1 !re w\ld h be5 no compla9t4 ,x _c be too (t5 emphasiz$ t x is aga9/ public int]e/ & sci5tific m$ic9e = physicians to be f9ancially int]e/$ 9 ! sale ( products :i* !y may be call$ on to prescribe = ! sick4 ,x is p]fectly true t !re are _m physicians :o w\ld n consci\sly p]mit f9ancial consid]ations to w>p _! judgm5t2 b x is n humanly possible to rema9 unbias$ 9 cases ( ?is sort4 ,x is conceivable t a judge on ! b5* might make e ef=t to disp5se imp>tial ju/ice 9 a suit 9 :i* "o ( ! p>ties 0 a firm 9 :i* he1 ! judge1 _h f9ancial int]e/4 ,nev]!less1 x w\ld be obvi\sly improp] = su* a judge to try a case ( ?is k9d4 ,yet1 9 ?is supposititi\s case ! only h>m t c\ld result w\ld be ( a f9ancial nature4 ,9 ! case ( ! physician1 ! h>m is n to ! public's purse b to ! public's heal?4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,dec4 #aa1 #aibj47 ,,pituit>y ,,gl& ,,prep>ations ,! importance ( ! /&>dization ( prep>ations ( ! po/]ior1 or infundibul>1 lobe ( ! pituit>y gl& 7! liquor hypophysis ( ! new ,unit$ ,/ates ,ph>macopeia1 pituit>y solution1 pituit>y extract1 etc47 is exemplifi$ by a rec5t publication ( ,ro?4#cjd ,z is well kn[n1 ! active con/itu5t or con/itu5ts ( ?is gl& h n be5 isolat$1 & !re is no *emical me?od ( det]m9+ ! activity & !rapeutic value ( v>i\s prep>ations4 ,!re are1 h[ev]1 c]ta9 physiologic me?ods by :i* ! activity ( su* prep>ations may be det]m9$ ) a consid]able degree ( exactness4 ,! la/ revision ( ! ,ph>macopeia1 recogniz+ t ! be/ atte/$ field ( usefulness = su* prep>ations is 9 ob/etrics1 adopt$ z a te/ _! activity on ! ut]us ( ! gu9ea-pig2 ! details ( ! me?od adopt$ by ! ,ph>macopeia are ^? describ$ by ,ro?4#cje ,ro? n[ reports on ! activity ( sev5 samples ( comm]cial infundibul> extracts1 ! products ( five ,am]ican manufactur+ ph>maci/s4 ,f\r ( ^! samples 7 f\nd to be ( ,ph>macopeia /r5g?2 ! o!r ?ree 7 mu* weak]4 ,( ! latt]1 "o _h b "o t5?1 ano!r b "o fif? & ! ?ird b "o f\r? ( ! requir$ activity4 ,^? prep>ations :i* _h be5 accept$ by ! ,c\ncil on ,ph>macy & ,*emi/ry = inclusion 9 ,new & ,non-(ficial ,rem$ies correspond$ to ! ,ph>macopeia requirem5ts4 ,ro? also comp>$ ! activity ( ^! sev5 prep>ations on ! blood pressure1 ano!r me?od by :i* x has be5 propos$ to /&>dize infundibul> extracts4 ,! f\r prep>ations :i* 7 equally active on ! ut]us 7 f\nd to be equally active on ! blood pressure2 ! o!r ?ree 7 mu* weak]4 ,ro? po9ts out1 h[ev]1 t ! results ( ! two me?ods are n necess>ily p>allel2 9 "o in/ance1 = example1 two samples caus$ equal rises ( blood pressure1 b "o 0 twice z active z ! o!r on ! ut]us4 ,h5ce x is evid5t t ! blood pressure te/ is n a satisfactory me?od = det]m9+ ! activity ( a prep>ation on ! ut]us1 & vice v]sa4 #cjd ,ro?1 ,g4 ,b43 ,pituit>y ,/&>dization1 ,bull #aji1 ,hyg4 ,lab41 ,u4 ,s4 ,p4 ,h4 ,s41 #aiag4 #cje ,ro?1 ,g4 ,b43 ,bull #ajj1 ,hyg4 ,lab41 ,u4 ,s4 ,p4 ,h4 ,s4 ,! subject ( pituit>y /&>dization1 or p]haps x may be said ! application ( ! pres5t me?od is1 h[ev]1 9 ne$ ( fur!r /udy4 ,?us ! /atem5t has rec5tly be5 made#cjf t comm]cial prep>ations are on ! m>ket :i* h f ?ree to five times ! activity ( ! ,ph>macopeia /&>d2 ?is 0 n ! case1 h[ev]1 ) ! prep>ations exam9$ by ,ro?4 ,x is probable t "s h us$ = comp>ison a weak] /&>d ?an t propos$ by ! ,ph>macopeia2 ?is1 ( c\rse1 w\ld lead to ! conclusion t ! comm]cial prep>ations 7 /rong] ?an ! ,ph>macopeia /&>d4 ,ro? sugge/s t ! employm5t ( /&>ds ( unequal activity by ! v>i\s supply h\ses c\ld easily be elim9at$ by hav+ a c5tral laboratory di/ribute mat]ial = use z a /&>d4 ,x w be recall$ t be=e ! ,unit$ ,/ates ,public ,heal? ,s]vice e/abli%$ & began ! di/ribution ( /&>ds = diph!ria & tetanus antitox9s1 ! comm]cial prep>ations ( ^! v>i$ ev5 m 9 activity ?an d ^? ( ! pituit>y extracts at pres5t4 #cjf ,pitt5g]1 ,p4 ,s41 & ,v&]kle$1 ,c4 ,e43 ,j\r4 ,am4 ,ph>m4 ,assn4 #f3aca1 #aiag4 ,x is unnecess>y to emphasize ! importance ( ?is subject2 ?is is suffici5tly evid5t to ^? :o h foll[$ ! rec5t cl9ical lit]ature on ! use ( pituit>y extracts 9 ob/etrics4 ,^! prep>ations are us$ 9 times ( em]g5cy2 a weak prep>ation is valueless1 :]eas ov]dosage1 ei!r f too /rong a prep>ation or f too free use ( a prep>ation ( ! (ficial /r5g?1 is (t5 foll[$ by disa/] to ! "m or *ild or bo?4 ,ro? cites a numb] ( cases ( ruptur$ ut]us & o!r injuries result+ f _! use4--7,editorial f ,! ,j\rnal ,a4 ,m4 ,a41 ,may #e1 #aiag47 ,,proprietor%ip ,,9 ,,m$ic9e ,to ! ,editor3--,i am enclos+ a repr9t ( my article on ! 8,pres5t ,/atus ( ,pituit>y ,extract 9 ,labor10 :i* appe>$ 9 ,! ,j\rnal1 ,june #b1 #aiag1 p4 #afja1 & also ! ,septemb] issue ( ,p>ke1 ,davis & ,company's ,!rapeutic ,notes1 on page #hi ( :i* !y quote ?is article1 t y may comp>e ! two4 ,! ,!rapeutic ,notes article is o/5sibly a copy1 b z a matt] ( fact1 x gives x only 9 "p1 :i* seems to me to be a gross misrepres5tation1 & "o :i* ,i d n ?9k %\ld g unnotic$4 ,joseph ,j4 ,mundell1 ,m4,d41 ,anaco/ia1 ,d4 ,c4 ,comm5t4--,!rapeutic ,notes is "o ( ! h\se organs ( ,p>ke1 ,davis & ,company4 ,a "p ( ea* issue is usually devot$ to 8exc]pts0 f curr5t lit]ature4 ,! ,!rapeutic ,notes may be judg$ f ! mann] ( 8exc]pt+0 ! article ( ,dr4 ,mundell4 ,naturally ! int]e/ ( ,p>ke1 ,davis & ,company is 9 ^? sections ( ! article :i* may be expect$ to promote ! use ( ,p>ke1 ,davis & ,company's propriet>y prep>ation ( pituit>y extract--pituitr94 ,! foll[+ passages f ! article ( ,dr4 ,mundell 7 n among ^? 8exc]pt$0 9 ,!rapeutic ,notes3 8,us$ "h 9 prop]ly select$ cases1 aft] due consid]ation by "o :o has good ob/etric judgm5t1 its results are usually happy1 & x is a boon to ! tir$ "m & h] att5dants40 8,to /ep beyond ^! n>r[ conf9es ( indications is inde$ ent]+ on dang]\s t]ritory4 ,especially is ?is true z reg>ds ! life ( ! baby4 ,x is recomm5d$ 9 small doses by "s good au?orities & is frequ5tly us$ 9 cases ( slight contraction at ! brim ) sometimes v good results if ! bir? occurs )9 a few m9utes1 b frequ5tly ) disa/r\s results to ! baby if deliv]y is delay$4 ,9 su* cases1 =ceps are urg5tly indicat$4 ,its use 9 su* cases is risky beyond "q4 ,pituit>y extract is recomm5d$ 9 cases ( po/p>tum hemorrhage1 b ergot is und\bt$ly to be pref]r$40 8,all means %\ld be exhau/$ to arrive at a def9ite diagnosis1 & ! dang]s ( its use %\ld be fully appreciat$ & due consid]ation giv5 be=e its adm9i/ration 9 any case1 = su* a p[]ful drug1 us$ indiscrim9ately1 w surely produce sad results to "m or *ild or bo?40 8,dur+ ! pa/ two ye>s a numb] ( unt[>d effects & consequ5ces ( sev]e "* h aris54 ,z f> z ! mat]nal accid5ts & complications are conc]n$1 ,i firmly believe t 7 ! slogan ( ! h\r 8safety fir/0 borne 9 m9d1 a numb] ( !m c\ld h be5 prev5t$1 = beyond "q ?is drug has be5 greatly abus$1 z x has be5 giv5 9 too l>ge doses1 9 cases 9 :i* its use 0 /rongly contra9dicat$1 & (t51 ,i am sorry to say1 = no reason o!r ?an ! acc\*eur's exp$i5cy4 ,its use has be5 reckless & c>eless4 ,! _m reports ( its rapid & safe action h be5 "o ( ! greate/ dang]s4 ,de,lee says1 #8,x provides = ! physician & 8 bro!r gynecologi/ a lot ( *ronic suff]]s1 (t5 incurable1 ev5 aft] mutilat+ op]ations4'0 8,an analysis ( ! detail$ reports ( all ^! cases ( ruptur$ ut]us ) "o or two exceptions reveals ! fact t pituit>y extract 0 abus$1 be+ giv5 to pati5ts :o %\ld n h _h x4 ,to my m9d1 to give a dose ( pituit>y extract to a woman :o has a contract$ pelvis1 mild or sev]e1 :5 ! head has n pass$ ?r\gh ! pelvis1 is crim9al &1 if ! ob/etrician is n aw>e ( ! contraction1 he is /ill little %ort ( be+ a crim9al40 ,9 ! latt] "p ( 8 article 9 ,! ,j\rnal1 ,dr4 ,mundell analyzes ! reports ( twelve cases ( rupture ( ! ut]us1 ?irty-f\r cases ( fetal dea?s1 & =ty-"o cases ( asphyxia pallida 9 :i* 8resuscitation 0 effect$ only aft] prolong$ & vigor\s ef=ts40 ,^! also 7 n exc]pt$4--,ed4--7,correspond5ce 9 ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #bd1 #aiag47 ,! ,manufactur]'s ,prote/ ,to ! ,editor3--,! article 9 ,! ,j\rnal1 ,novemb] #bd1 page #ahah1 on proprietor%ip 9 m$ic9e does u a gross inju/ice1 & 9 reply !reto we beg leave to submit ! foll[+3 ,= reasons :i* e publi%] 7y\rself includ$7 und]/&s1 x is n practicable = u to reproduce 9 full1 9 ! columns ( ,!rapeutic ,notes1 all ! cl9ical pap]s to :i* we wi% to direct ! att5tion ( our read]s4 ,b t ! article ( ,dr4 ,mundell 0 n g>bl$ to make capital = ,p>ke1 ,davis ,co4 is q app>5t on comp>ison ( ! omitt$ portions ) a previ\s pap] by ! same au?or1 repr9t$ 9 ! ,janu>y 7#aiag7 issue ( ! ,notes1 & h]e) submitt$ toge!r ) clipp+s f o!r issues ( ! ,notes :i* prove t we h n hesitat$ to pres5t to our read]s ! dang]s incid5tal to ! misuse ( ,pituitr9 z well z ! advantages ( its prop] use4 ,!rapeutic ,notes1 9 quot+ o!r j\rnals1 puts into its read]s' h&s ! means ( inve/igat+ ! fairness ( its quotations4 ,x is a h\se organ--true en\gh2 b ! organ ( a h\se :i* has always appeal$ to ! honor z well z to ! progressiv5ess ( ! m$ical pr(ession4 ,its publi%]s c\ld n af=d to resort to deception 9 adv]tis+ _! products1 ?r\gh ?is or any o!r m$ium4 ,! pr(ession is indebt$ to ,p>ke1 ,davis ,co4 = ,pituitr9 7among o!r m$icam5ts71 & x is to ! pr(ession t ! manufactur]s look = ! ultimate v]dict4 ,! contra9dications are q z important z ! indications1 &1 z ! exc]pts submitt$ %[1 we h tak5 acc\nt ( ^!1 n only 9 =m+ our own e/imate1 b 9 pres5t+ ! evid5ce to ! read]s ( ,!rapeutic ,notes4 ,we cite ^! facts t y may give u a squ>e deal 9 an e>ly issue ( ,! ,j\rnal if s dispos$4 ,p>ke1 ,davis ,co41 ,detroit4 ,comm5t4--,! ,j\rnal has no desire to discuss ,p>ke1 ,davis & ,company's motives 9 omitt+ c]ta9 p>ts ( ,dr4 ,mundell's pap]4 ,:at ,! ,j\rnal did 0 to publi% ^? p>ts ( ,dr4 ,mundell's pap] on ! 8,pres5t ,/atus ( ,pituit>y ,extract 9 ,labor0 t ,p>ke1 ,davis & ,company left out ( _! circul>4 ,t x is n practicable1 z ,p>ke1 ,davis & ,company po9ts out1 = ! manufactur]s ( propriet>y products to reproduce 9 full all cl9ical pap]s deal+ ) su* products is obvi\s4 ,x is n s obvi\s :y su* conc]ns 9 ab/ract+ or quot+ pap]s ( ?is k9d %\ld delete ^? p>ts t are unfavorable to ! products dealt ) r ?an ^? t are favorable4 ,curi\sly1 h[ev]1 :5ev] an au?or is quot$ only 9 "p ^? p>ts are almo/ inv>iably ^? favorable to ! product4--,ed4--7,correspond5ce 9 ,! ,j\rnal ,a4 ,m4 ,a41 ,dec4 #h1 #aiag47 ,:y ,propriet>ies ,fl\ri% ,to ! ,editor3--,! foll[+ exp]i5ces seem to add "o m to ! _m reasons (f]$ to expla9 :y propriet>ies & ready-made prep>ations fl\ri% at ! exp5se ( ! (ficial drugs & prep>ations3 ,a few days ago ,i prescrib$ ,tro*es ( ,ammonium ,*loride1 ,u4 ,s4 ,p41 = a pati5t ( exceptional p]sev]ance4 ,! next day he _h n yet secur$ ! tro*es & told me t he _h submitt$ ! prescription to sev5 ph>macies1 includ+ ! l>ge/1 & ?ree ( ! be/ kn[n & admitt$ly ! be/ equipp$ 9 ,new ,york4 ,all told him t ^! tro*es 7 8n be+ made any m10 & t !y 7 !re=e unable to supply him4 ,he !reupon communicat$ ) "o ( ! l>ge/ :olesale manufactur+ ph>maceutical h\ses 9 ,am]ica & receiv$ precisely ! same answ]4 ,i !n took ! matt] up ) a fir/ class ph>maci/ :om ,i knew & induc$ him to prep>e ?is difficult 767 tro*e1 = :i* ! ,u4 ,s4 ,ph>macopeia gives ! foll[+ directions3 8,rub ! p[d]s toge!r until !y are ?or\ghly mix$2 !n =m a mass ) syrup ( tolu & divide 4440 ,sev5 ph>maci/s decl9$ to fill a prescription = an (ficial prep>ation because !y c\ld n buy ! prep>ation f a :olesal]1 & x requir$ "s p]suasion to get ! eigh? to make ! prep>ation4 ,b ev5 worse1 sev]al ( ! ph>maci/s (f]$ my pati5t "s ready-made tro*e m or less resembl+ ! (ficial1 or (f]$ compress$ tablets ( ammonium *lorid4 ,t ?is is n an isolat$ example ( :at (t5 poses z ph>macy is %[n by ! fact t ,i h f\nd x extremely difficult to f9d a ph>maci/ :o w\ld extemporane\sly coat pills ) gelat94 ,mo/ want ! physician to alt] 8 prescription s t "o ( ! ready-made gelat9 coat$ pills c be disp5s$1 if a gelat9 coat+ is necess>y4 ,"s gelat91 hot wat]1 a l>ge cork1 & a few dome/ic sew+ ne$les are all t is requir$ = v satisfactory coat+ ( pills ) gelat91 yet few ph>maci/s seem will+ to p]=m ?is simple proc$ure4 ,two o!r illu/rations1 n s rec5t1 h come to me f a colleague4 ,a few ye>s ago he 0 unable to obta9 f ei!r ( two ph>maci/s an emulsion ( cod liv] oil )\t ! hypophosphites because1 z bo? said1 8,x does n come )\t hypophosphites40 ,on ano!r occasion f\r ( ! be/ drug /ores 9 ,bo/on 7 ask$ = ! ,comp\nd ,laxative ,pill1 ,u4 ,s4 ,p41 !n (ficial 9 ! ,ph>macopeia4 ,9 e case he 0 told t he mu/ h meant ! comp\nd ca?>tic pill1 :i* 9 no way resembles ! pill he s\ght4 ,) ?is attitude on ! "p ( ! m5 suppos$ to be s]v+ ! public & ! m$ical pr(ession by ! practice ( ph>macy1 is x any wond] t x is difficult to induce ! m$ical pr(ession to prescribe (ficial prep>ations or comb9ations ( (ficial drugs 9 place ( ready-made comm]cial sub/itutes l>gely drawn f among ! propriet>ies or specialties8 ,real ph>macy by real ph>maci/s is a necessity if we are to succe$ 9 combat+ ! propriet>y evil4 ,c>y ,eggle/on1 ,m4,d41 ,new ,york4 --7,correspond5ce 9 ,! ,j\rnal ,a4 ,m4 ,a41 ,aug4 #ba1 #aibj47 ,,philip ,,rahtj5 ,,& ,,8 ,,discov]ies ,rec5t newspap] reports reg>d+ ! alleg$ 8discov]y ( ! ,g]m ( ,p]nici\s ,anemia0 & ! developm5t ( 8an antitox9 & s]um0 by ,dr4 ,philip ,rahtj5 ( ,pasad5a1 ,cali=nia1 h br\ght inquiries ( :i* ! two t foll[ are typical4 ,?is f a physician 9 ,indiana3 8,please let me "k ab\t ! suppos$ rec5t discov]y ( ,dr4 ,philip ,rahtj5 conc]n+ p]nici\s anemia4 ,! in=mation ,i h is f a newspap] clipp+ ( ,octob] #ba1 ,pasad5a1 ,cali=nia4 ,k9dly omit my "n40 ,a ,new ,york physician writes3 8,if y c\ld s5d me any in=mation z to ! enclos$ ,i w\ld appreciate x4 ,! article impresses "o z absolutely inconclusive4 ,h[ev]1 ,i promis$ ! pati5t ,i w\ld inve/igate ! matt]40 ,! enclosures ref]r$ to consi/$ ( a repr9t & a lett] f 8,ph4 ,rahtj51 ,m4,a41 ,ph4,d410 ,pasad5a1 ,calif41 bo? ( :i* _h be5 s5t to a layman :o _h writt5 to ,rahtj54 ,! repr9t 0 a translation ( a brief article by ,rahtj5 8,on ! ,etiology ( ,idiopa?ic ,anemia10 translat$ f ! ,c5tralblatt fr ,bakt]iologie ,p>asit5kunde und ,infektionskrankheit54 ,rahtj5's lett] to ! layman read3 8,y\r inquiry relative to my isolation & classification ( ! ,g]m ( ,anemia receiv$4 8,i h]e9 enclose my pap] publi%$ 9 ,augu/ 9 ! ,c5tral ,magaz9e ( ,bact]iology4 8,i h succe$$ 9 immuniz+ goats aga9/ ! ,g]m !re9 describ$4 ,five ?\s& injections ( ! ,s]um h be5 giv54 ,?ree hundr$ cases diagnos$ z ,anemia & ,*lorosis 7 treat$ "u obs]vation4 ,six cases ( ,p]nici\s ,anemia 7 obs]v$ "u treatm5t4 ,all respond$ favorably4 8,! ,s]um is at y\r disposal f my laboratory "h = ! use ( y\r physician4 ,! price is five doll>s = twelve amp\les ea* conta9+ #a ccm41 ! am\nt ( "o injection4 8,! treatm5t consi/s ( intramuscul> injection e second day accompani$ ) a nitrog5\s free diet1 pref]ably milk diet4 ,y\r att5d+ physician %\ld v easily give !m40 ,j :at ,rahtj5's s]um is we d n "k4 ,nor h we be5 able to f9d any in=mation on ! subject 9 any available m$ical lit]ature4 ,9 fact1 a r c>eful se>* ( ,am]ican m$ical lit]ature = "s ye>s pa/ fails to reveal any article by ,rahtj5 on any subject4 ,philip ,rahtj5 is n a physician4 ,9 ! ,propag&a files is a circul> issu$ 9 #aiag by ! 8,rahtj5 ,tub]culosis ,sanatorium0 ( ,san ,francisco1 ,calif4 ,?is exploits 8,! ,rahtj5 ,cure = ,tub]culosis0 & tells ( 8,! ,discov]y ( ,dr4 ,philip ,rahtj540 ,! circul> /ates t3 8,dr ,rahtj5 /udi$ 9 ,heidelb]g1 ,b]l91 ,muni*1 ,m>burg1 & ,ro/ock1 ,g]many1 f :i* latt] s*ool 9 #aijd1 he graduat$ 9 *emical pa?ology z ,doctor ( ,philosophy4 ,he became assi/ant pr(essor ( pa?ology at ! ,imp]ial ,biological ,/ation at ,heligol&1 & 0 lat] appo9t$ assi/ant to ,dr4 ,piork[sky1 head ( ! ,deuts*e ,s*utz und ,heils]um ,gesells*aft40 ,! same circul> summ>izes ! pot5tialities ( 8,rahtj5's ,cure = ,tub]culosis0 ?us3 8,! rem$y seems to cure tub]culosis 9 all its =ms ) equal cel]ity & c]ta9ty4 ,! evid5ces indicate t x does n matt] h[ f> ! disease has progress$1 if !re be tissue ( ! attack$ organ rema9+ suffici5t to su/a9 life1 ! disease c be :olly eradicat$ & ! pati5t re/or$ to heal?4 ,?is is indicat$ alike 9 tub]culosis ( ! lungs1 ( ! ?roat1 ( ! bladd]1 ( ! kidneys40 ,! booklet /at$ fur!r t pati5ts might be treat$ at "o ( two places3 at ! (fices ( ! sanatorium 9 ! city ( ,san ,francisco1 or at ! sanatorium itself ne> ,gl5wood4 ,! co/ ( treatm5t at ! sanatorium 0 to be #a1jjj1 :i* w\ld entitle 8! pati5t to resid5ce & att5tion !re = f\r mon?s40 ,accord+ to ! leaflet1 8,?is is reg>d$ z a p]iod suffici5t to re/ore ! pati5t to heal? :atev] be ! /age ( 8 disease2 provid$ only1 z we rem>k1 t he has en\gh left ( ! infect$ organ to su/a9 life ) ! ,t4 ,b4 expell$40 8,at ! end ( f\r mon?s ! pati5t is s5t to 8 home1 n alone reliev$ ( 8 disease1 b 9 a highly vigor\s /ate ( heal?40 ,all ?is1 z /at$ previ\sly1 0 9 #aiag4 ,& yet p are /ill dy+ ( tub]culosis6 ,9 ,m>*1 #aibj1 ,rahtj5 7s ! newspap]s h x7 0 (f]+ a 8,new-,life ,fluid40 ,accord+ to a ,san ,francisco pap]1 ,dr4 ,philip ,rahtj5 8ann\nces ! discov]y t by ! injection ( secretions f ! ductless gl&s ! human body may be re9vigorat$40 ,! pap] describ$ ! discov]y 8z a long /ep =w>d 9 ! fight to c\nt]act old age0 & /at$ t a syndicate 0 be+ =m$ by ,rahtj5 & o!rs to 8produce ! extract 9 su* quantity t x may be available = e "o40 ,! newspap] article %[$ ! le>n$ doctor 9 a laboratory apron 9 ! *>act]i/ic pose ( ! newspap] 8sci5ti/0 p\r+ some?+ f a beak] into a te/ tube--& gaz+ int5tly at ! cam]a :ile do+ x6 ,?is 0 9 ,m>*1 #aibj2 yet p /ill gr[ old4 ,)9 ! la/ mon? ! ,los ,angeles ,exam9] has h]ald$ "s m wond]ful accompli%m5ts ( ,rahtj54 ,accord+ to ?is pap] ,rahtj5 has3 #a4 ,isolat$ ! 8g]m ( p]nici\s anemia40 #b4 ,f\nd ! 8s]um0 = ! cure ( ?is disease4 #c4 ,discov]$ ! secret ( human virility4 #d4 ,evolv$ a fluid 8f ! gl&s ( select$ bulls & c[s0 :i* w 8re/ore #8pep' = worn-out human bodies6 ,give add$ weight1 cle>] eyes1 bright] m9ds1 quick] bodies & a g5]ally #8firm] grip' on oneself60 ,?is 8amaz+ discov]y0 01 accord+ to ! ,los ,angeles pap]1 ! culm9ation ( 8five ye>s ( cont9u\s /udy0 & _h only j be5 reveal$ by ,rahtj54 8,dr4 ,rahtj5 has = ye>s be5 work+ sil5tly 9 a bio-*emical laboratory 9 ,pasad5a1 surr\nd$ by microscopes1 scales1 te/-tubes1 acids1 alkalis1 reag5ts & all ! accompany+ /age sett+s t spell bio-*emical sci5ce40 ,all ( ^! wond]s might /ill h be5 a clos$ book to ! public _h n 8fri5ds0 ( ,dr4 ,rahtj5 br\ght ! matt] to ! att5tion ( ! ,exam9]4 8,dr4 ,rahtj5 ye/]day1 ) ! usual res]ve ( ! e?ical sci5ti/1 0 dis9cl9$ to talk ( 8 "w until publication ( x 9 a sci5tific j\rnal40 ,=tunately = a palpitat+ public1 ! ,los ,angeles ,exam9] 80 able to le>n ! ess5ce ( 8 /udy0 & pass ! in=mation on4 ,x seems f ?is newspap] report t ,rahtj5 fir/ made 8 extracts f ! gl&s ( goats & %eep b ^! extracts 87 f\nd to be too /rong40 ,z a result 8,dr4 ,rahtj5 is n[ us+ ! gl&s ( specially select$ ,mexican bulls & c[s40 ,! male pati5ts :o are 8weak1 un9t]e/$ 9 life1 unable to conc5trate 9 ?\ght0 are giv5 ! extract ( bull2 ! female pati5ts :o are 9 a simil>ly deplorable condition receive an 8injection ( ! c[ gl& extract40 ,we h n yet le>n$ :e!r ! ,los ,angeles ,exam9] has deprecat$ ,dr4 ,rahtj5's use ( ,mexican bov9es4 ,rememb]+ ! attitude ( ! ,he>/ pap]s t[>d all ?+s ,mexican1 "o may look = ! sugge/ion t ,mr4 ,rahtj5 use #ajj p] c5t4 ,am]ican bull4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #bf1 #aiba47 ,,sodium ,,cacodylate ,,9 ,,syphilis ,to ! ,editor3--,i 0 mu* int]e/$ 9 ! /udy ( ?is subject by ,dr4 ,h4 ,n4 ,cole 7,! ,j\rnal1 ,dec4 #cj1 #aiaf1 p4 #bjab47 ,9 #aiac ,i treat$ a s]ies ( cases ( syphilis ) sodium cacodylate2 b1 n gett+ ! desir$ results1 ,i discont9u$ its use4 ,9 #aiae1 ,i became int]e/$ aga9 because ( ! writ+s ( ,dr4 ,j4 ,b4 ,murphy1 & appli$ x 9 ?ree cases 9 :i* ! pati5ts _h initial lesions3 ,,case #a4--;,j4 ,m41 man ag$ #ba1 s+le1 %oework]1 came to me ) an initial lesion ( ! p5is to ! "r ( ! fr5um4 ,i began intramuscul> injections ( sodium cacodylate1 #e gra9s1 9 ampules made by ,p>ke1 ,davis ,co41 e day = t5 days4 ,!n ,i halt$ = t5 days & repeat$ t5 m injections4 ,! sore on ! p5is entirely disappe>$ ab\t ! n9? day4 ,!re 0 a slight1 fa9tly macul> eruption ( ! =e>ms & abdom51 :i* soon disappe>$4 ,!re 0 no alopecia4 ,:5 he return$1 aft] ! la/ s]ies ( t5 injections1 !re 7 muc\s pat*es 9 ! ?roat & "s involvem5t ( ! left tonsil4 ,i put ! pati5t on mix$ treatm5t1 :i* cle>$ 8 ?roat4 ,he _h1 at end ( tw5ty doses ( #e gra9s ( sodium cacodylate ea*1 a positive ,wass]mann reaction4 ,aft] m]cury & potassium iodid = two mon?s !re 0 a positive ,wass]mann reaction4 ,to date1 aft] ?ree salv>san treatm5ts intrav5\sly !re h be5 two negatives4 ,,case #b4--;,f4 ,s41 man1 ag$ #bh1 m>ri$1 ma*9i/1 _h an initial lesion on ! p5is4 ,treatm5t ) sixty injections ( #e gra9s ( sodium cacodylate gave results z foll[s3 ,! initial sore on ! p5is disappe>$ 9 t5 injections2 !re 7 sev]e muc\s pat*es ( ! m\?2 ! tonsils 7 badly infect$4 ,!re 0 a positive ,wass]mann reaction4 ,!re 7 syphilids ( bo? arms & %9s2 m>k$ papul> eruption2 malaise1 & a slight trace ( album9 9 ! ur9e4 ,i plac$ ! pati5t on m]curials & at la/ give him ?ree salv>san injections ?ree weeks ap>t4 ,! result 0 a negative ,wass]mann reaction1 ! sk9 0 cle> & ! pati5t felt f9e4 ,,case #c4--;,d4 ,c41 woman1 ag$ #ba1 s+le1 seam/ress1 _h an initial lesion on ! left side ( ! c]vix1 & a macul> eruption on ! face1 neck & %\ld]s1 & also1 ?\gh fa9t1 on ! =e>ms4 ,?irty injections ( sodium cacodylate ( #e gra9s ea* 7 giv54 ,! initial lesion disappe>$ 9 "o week4 ,muc\s pat*es ( ! m\? appe>$ & p]si/$4 ,! ,wass]mann reaction 0 positive4 ,i gave m]curials & potassium iodid = sev5 mon?s1 & salv>san once4 ,! ,wass]mann reaction is n[ negative4 ,my conclusion aft] two trials ( ! use ( sodium cacodylate 9 small or l>ge doses is t x has no effect t[>d cur+ ! condition2 9 fact1 ! ?roat symptoms 7 seem+ly increas$ 9 sev]ity by its use4 ,x has no effect on syphilids ( ! =e>ms & %9s1 & if any?+ makes !m worse4 ,x improves ! appetite1 z "o w\ld expect4 ,x has "s effect on ! kidneys1 z not$ 9 ,case #b2 x has "s effect 9 heal+ ! initial lesion1 z not$ 9 all ?ree ( ?is s]ies2 :y1 ,i d n "k4 ,i am entirely satisfi$ t x has no b5eficial effect on syphilitics & h discont9u$ its use entirely 9 my practice4 ,i am glad to h read ,cole's excell5t article1 z x %[s me t ,i 0 correct 9 my decision n to use x aga91 z x 0 wor?less4 ,william ,g4 ,w>d1 ,m4,d41 ,lynn1 ,mass4 ,to ! ,editor3--,dr4 ,william ,g4 ,w>d's lett] 7,! ,j\rnal1 ,feb4 #c1 #aiag1 p4 #cij71 & ! rec5t admirable article by ,dr4 ,h>old ,n4 ,cole 7,! ,j\rnal1 ,dec4 #cj1 #aiaf1 p4 #bjab7 recall to m9d ,dr4 ,j4 ,b4 ,murphy's cl9ical note on ! use ( sodium cacodylate 9 ! treatm5t ( syphilis 7,! ,j\rnal1 ,sept4 #bd1 #aiaj1 p4 #aaac71 & ! exp]im5tal "w ( ,cap4 ,h4 ,j4 ,ni*ols1 ,u4 ,s4 ,army 7,! ,j\rnal1 ,feb4 #ah1 #aiaa1 p4 #dib74 ,! results ( ,ni*ols' "w conclusively prov$1 at lea/ f a laboratory /&po9t1 t ?is drug 0 ( v little value z a spiro*eticide 9 combat+ syphilis4 ,prior to ! publication ( ,dr4 ,murphy's lett] ,i _h employ$ sodium cacodylate ext5sively z a rem$y 9 psoriasis1 & ,i /ill cont9ue to use x 9 select$ cases ( ! disease4 ,adopt+ ,dr4 ,murphy's sugge/ion1 ,i gave ! ag5t an ext5sive trial 9 syphilis 9 all /ages ( ! disease4 ,! results 7 extremely disappo9t+1 f bo? cl9ical & s]ologic po9ts ( view4 ,m rec5tly1 dur+ ! sc>city ( salv>san1 ,i gave ! drug a second trial1 employ+ x 9 l>ge dosage 9 ! hope t ! previ\s failure _h be5 due to ! employm5t ( insuffici5t am\nts4 ,! results 7 n tabulat$1 b1 judg+ r\ghly f my exp]i5ce 9 a score ( cases1 its !rapeutic value z an antisyphilitic 0 nil4 ,a few ( ! pati5ts und]w5t a tempor>y improvem5t1 probably ow+ to ! tonic effect ( ! drug1 b 9 e in/ance ! s]ologic f9d+s 7 unaffect$4 ,r4 ,l4 ,sutton1 ,m4,d41 ,kansas ,city1 ,mo4 --7,correspond5ce 9 ,! ,j\rnal ,a4 ,m4 ,a41 ,feb4 #c1 #aiag47 ,,tablets3 ,,dep5dability ,,( ,,dosage ,! tablet =m ( adm9i/]+ m$ic9es is popul> among _m physicians because ( its conv5i5t availability & dosage4 ,!re is no d\bt ab\t ! conv5i5ce ( tablets1 b ! accuracy ( ! dosage cont5t is n always to be dep5d$ on4 ,"o reason = ?is is t ! dem& = palatable & conv5i5t 8m$icam5ts has l$ manufactur]s to attempt to produce 9 tablet =m mixtures :i*1 f ! nature ( ! case1 are n suit$ to t me?od ( comp\nd+40 ,9 a s]ies ( pa9/ak+ exp]im5ts#cjg on bismu?1 opium & ph5ol tablets1 conduct$ a numb] ( ye>s ago 9 ! ,a4 ,m4 ,a4 ,*emical ,laboratory1 x 0 %[n t no tablets on ! m>ket !n conta9$ ! am\nt ( ph5ol ! label indicat$1 ! v>iation be+ f #ab4c to #aab4e p] c5t4 ,simil>ly1 ! laboratory f\nd t 9 ! case ( sev]al diff]5t br&s ( ,aromatic ,dige/ive ,tablets1#cjh ! am\nt ( hydro*loric acid pres5t 9 ^! absurd comb9ations 0 true to label 9 only "o half ( ! specim5s1 not)/&+ ! fact t ! am\nts claim$ to be pres5t 7 ridicul\sly small2 9 two specim5s1 !re 0 no hydro*loric acid :atev] pres5t1 :ile a ?ird conta9$ only a trace4 ,^! examples illu/rat$ cle>ly ! v evid5t unwisdom ( attempt+ ! ph>maceutically impossible m]ely = ! sake ( conv5i5ce or ph>maceutical 8elegance40 #cjg ,puckn]1 ,w4 ,a41 & ,cl>k1 ,a4 ,h43 ,exam9ation ( ,tablets ( ,bismu?1 ,opium & ,ph5ol1 ,! ,j\rnal ,a4 ,m4 ,a41 ,july #be1 #aijh1 p4 #ccj4 ,puckn]1 ,w4 ,a41 & ,hilp]t1 ,w4 ,s43 ,tablets ( ,bismu?1 ,opium & ,ph5ol1 ,dec4 #ag1 #aiaj1 p4 #bafi1 ,may #f1 #aiaa1 p4 #acdd4 ,unreliable ,ph>maceutical ,products1 editorial1 ,may #f1 #aiaa1 p4 #acce4 #cjh ,puckn]1 ,w4 ,a41 & ,w>r51 ,l4 ,e43 ,aromatic ,dige/ive ,tablets1 ,! ,j\rnal ,a4 ,m4 ,a41 ,aug4 #bj1 #aiaj1 p4 #gaj4 ,ano!r reason = d\bt+ ! accuracy ( dosage1 irrespective ( ! *>act]i/ics ( ! drugs compos+ ! tablets1 has be5 ! manife/ lack ( c>e 9 _! manufacture4 ,9 #aiad1 ,kebl]#cji report$ ! results ( a f>-rea*+ inve/igation ( tablet comp\nd+ 9 :i* he po9t$ out t tablets on ! m>ket 7 n z uni=m or accurate z 0 g5]ally believ$1 ! v>iations be+ 8unexpect$ly l>ge 9 numb]s & am\nt40 ,dur+ ! pa/ ye>1 ! ,connecticut ,agricultural ,exp]im5t ,/ation#caj und]took ! exam9ation ( tablets--propriet>y & nonpropriet>y--tak5 f ! /ock ( disp5s+ physicians4 ,! v>iations f\nd 9 weights ( ! tablets 7 /rik+ly simil> to ^? report$ by ,kebl]4 #cji ,kebl]1 ,l4 ,f43 ,! ,tablet ,indu/ry1 ,j\r4 ,am4 ,ph>m4 ,assn41 #aiad1 #c1 #hbj1 #icg1 #ajfb4 #caj ,bull4 #bjj1 ,connecticut ,agricultural ,/ation1 ,food & ,drug ,products1 #aiag1 p4 #afa4 ,,v>iation ,,9 ,,weights ,,( ,,tablets ,kebl] ,connecticut ,v>iation ,p] ,c5t4 ,p] ,c5t4 ,less ?an #aj p] c5t4 #dc #dd ,m ?an #aj p] c5t4 #eg #ef ,m ?an #ab p] c5t4 #dd #ce ,m ?an #ae p] c5t4 #bh #bf ,m ?an #bj p] c5t4 #i #aj ,! det]m9ations ( ! composition ( ! tablets :5 comp>$ ) t claim$ = !m %[$ wide v>iation--f #ed p] c5t4 above to #gj4e p] c5t4 bel[2 9 almo/ two ?irds ( ! tablets exam9$1 ! v>iation am\nt$ to m ?an #aj p] c5t42 9 ?ree fif?s ( ! tablets1 ! v>iation 0 m ?an #ae p] c5t42 9 "o f\r?1 m ?an #bj p] c5t41 & 9 "o tw5tie?1 m ?an #ej p] c5t42 only 9 "o eigh? ( ! tablets 0 ! v>iation less ?an #e p] c5t4 ,! ,connecticut inve/igators sub/antiate once aga9 ! "w previ\sly report$1 namely1 t !re are a numb] ( firms :o are ei!r incompet5t or c>eless4 ,= tablets ( simple composition1 a v>iation f ! decl>ation ( #aj p] c5t4 %\ld be amply suffici5t to comp5sate = ! errors ( c>eful manufacture4 ,x may be add$ t ! be/ tablets orig9ate g5]ally f firms hav+ compet5t *emical control4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,july #bg1 #aiah47 ,,!rapeutic ,,evid5ce3 ,,its ,,crucial ,,te/,o ,torald ,sollmann1 ,m4,d41 ,clevel& ,o ,read be=e ! ,section on ,ph>macology & ,!rapeutics at ! ,sixty-,eigh? ,annual ,session ( ! ,am]ican ,m$ical ,association1 ,new ,york1 ,june1 #aiag4 ,o ,?is article cle>ly /ates ! difficulties exp]i5c$ by ! ,c\ncil 9 e/imat+ ! m]its ( a propriet>y m$ic9al product & cle>ly def9es ! me?od :i* has be5 f\nd to be practical 9 judg+ ( ! !rapeutic value ( su* prep>ations4 ,! ,c\ncil has approv$ ?is discussion ( ! subject & has direct$ t ! pap] be publi%$ 9 ! annual ,c\ncil reports4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,accord+ to ! good old truism1 ! la/ & crucial pro( ( ! pudd+ is 9 ! eat+ !re(2 & s1 ! la/ & crucial te/ ( a !rapeutic ag5t is its consumption by a pati5t4 ,!re is1 h[ev]1 "o ess5tial diff]5ce3 ,:5 ! pudd+ is eat51 ) a s5se ( satisfaction1 we "k t x 0 a good1 or at lea/ an eatable1 pudd+4 ,if ! pati5t improves aft] tak+ a rem$y1 we d n yet "k t he improv$ on acc\nt ( ! rem$y4 ,! po/ hoc type ( reason+ or logic is n respectable2 b x is all too apt to creep 9 unaw>es1 unless "o takes great precautions inde$4 ,cl9ical evid5ce ne$s especially to be on its gu>d aga9/ ?is pitfall1 = ! conditions ( disease nev] rema9 con/ant2 nor is x possible to =esee ) c]ta9ty ! direction :i* !y are go+ to take4 ,x is j ?is po9t :i* makes ! cl9ical evid5ce s mu* m difficult to int]pret ?an laboratory evid5ce1 9 :i* ! conditions c be m or less exactly controll$1 & any *anges =ese54 ,x is on ?is acc\nt1 also1 t cl9ical exp]im5ts mu/ be surr\nd$ ) extra pa9/ak+ precautions4 ,9 brief1 :ile ! 8pro(0 ( a rem$y is on ! pati5t1 t is n ! :ole /ory1 b m]ely an introduction4 ,! real problem is to e/abli% ! causative connection betwe5 ! rem$y & ! ev5ts4 ,! imp]fect realization ( ?is has block$ !rapeutic advance1 has disgu/$ critical m5 to ! po9t ( !rapeutic nihilism1 & has f]tiliz$ ! gr\nd = ! comm]cial exploitation ( drugs t are ( d\btful value or worse4 ,?is has be5 impress$ on me p>ticul>ly by my s]vice on ! ,c\ncil on ,ph>macy & ,*emi/ry4 ,9 ! c\rse ( its "w ( pass+ on ! claims advanc$ = comm]cial rem$ies1 ?is ,c\ncil is =c$ to inquire critically into ! basis ( ! claims ( manufactur]s4 ,x is int]e/+ to note ! qualitative diff]5ces 9 ! evid5ce = ! v>i\s k9ds ( claims3 ,! *emical data are usually pres5t$ 9 su* a =m t x is possible to tell at a glance :e!r or n !y are bas$ on demon/rat$ facts1 :i* c\ld usually be v]ifi$ or refut$ )\t special difficulty4 ,! d$uctions are usually su* z c be legitimately drawn f ! data1 or else !y are obvi\sly absurd4 ,all ?is agrees ) ! relatively exact /atus ( *emical sci5ce4 ,9 pass+ to data & d$uctions f animal exp]im5ts1 a di/9ct *ange is noticeable3 ,n only are ! data less reliable1 & less wor?y ( confid5ce1 b !y are m (t5 /at$ 9 a less /raight=w>d mann]4 ,! pres5tation ( ! data (t5 %[s evid5ce ( manipulation ( ! results1 s z to make !m mo/ favorable to a preconceiv$ conclusion t w\ld recomm5d ! drug4 ,?is is n always int5tional1 b is p>tly due to ! less exact nature ( animal exp]im5tation1 :i* leaves a wid] play to ! arbitr>y int]pretation ( ! report]4 ,a c]ta9 am\nt ( ?is is unavoidable4 ,no s]i\s objection c be rais$1 provid$ ! exp]im5t] pres5ts all ! ess5tial data1 & discusses fairly all ( ! int]pretations t w\ld apply to !m4 ,on ! :ole1 x is usually possible to =m a fairly def9ite e/imate ( ! value ( exp]im5tal data4 ,:5 "o comes to ! cl9ical evid5ce1 an entirely diff]5t atmosph]e obta9s4 ,:5 ! ,c\ncil dem&s evid5ce ( ! usefulness ( a rem$y1 ! manufactur]s g5]ally respond ) e sign ( en?usiasm4 ,!y may h ready a s]ies ( articles already publi%$1 or !y in/ruct _! ag5ts to br+ 9 lett]s f physicians4 ,! la/ me?od seems to meet ! mo/ cordial response1 judg+ f ! deluge ( lett]s & op9ions t floods ! ,c\ncil4 ,! quality ( ! publi%$ pap]s is a fair reflection ( ! defici5cies ( :at is /ill ! common type ( cl9ical evid5ce4 ,a little ?\ght suffices to %[ t ! great] "p _c be tak5 z s]i\s evid5ce at all4 ,"s ( ! data are m]ely impressions--usually ! late/ impressions ( an impressionable en?usia/--! type ( man :o does n consid] x necess>y to pres5t evid5ce = 8 own op9ions2 ! type ( man :o does n ev5 realize t sci5tific conclusions mu/ be bas$ on objective ph5om5a4 ,"s ( ! pap]s masqu]ade z 8cl9ical reports10 sometimes ) a spl5did disreg>d = all details t c\ld enable "o to judge ( _! value & be>+1 sometimes ) ! mo/ t$i\s pres5tation ( all sorts ( r\t9e obs]vations t h no relation to ! problem4 ,! majority ( reports obta9$ by ! ag5ts belong to ^! classes1 not)/&+ ! fact t !y are (t5 writt5 = ! special use ( ! ,c\ncil1 & !re=e ) ! realization t !y are likely to be subject$ to a ?or\gh exam9ation1 & !re=e presumably repres5t+ ! be/ type ( "w ( :i* ! report] is capable4 ,s1 at lea/1 "o w\ld suppose4 ,x is also possible1 h[ev]1 t "s ( ^! reports are writt5 m]ely out ( ?\ghtlessness1 or p]haps (t5 to get rid ( an importunate ag5t4 ,?is is illu/rat$ by ! foll[+ correspond5ce1 tak5 lit]ally f ! files ( ! ,c\ncil4 ,a lett] f a prom95t physician 8,a10 endors+ a c]ta9 prep>ation 8,d10 hav+ be5 submitt$ to ! ,c\ncil1 ! secret>y 0 direct$ to write to ,dr4 ,a z foll[s3 ,de> ,dr4 ,a3--,! ,b ,company ( ,c has reque/$ ! ,c\ncil on ,ph>macy & ,*emi/ry to admit its prep>ation ,d to ,new & ,non(ficial ,rem$ies4 ,z "p evid5ce = ! value ( ! prep>ation1 ! company submitt$ a lett] f y :i* conta9s ! foll[+3 ,s f> z my exp]i5ce has ?us f> gone1 !y are c]ta9ly sup]ior to a numb] ( o!r iod9e comp\nds n[ on ! m>ket1 & ,i %\ld judge t !y ought to take a sup]ior place 9 !rapy involv+ ! use ( iod9e4 ,! ref]ee ( ! ,c\ncil 9 *>ge ( ,d writes t he 0 int]e/$ by y\r lett] & asks t ,i inquire3 ,z comp>$ ) sodium or potassium iodid1 :at w\ld y say are ! diff]5ces betwe51 & real advantages (1 ,d & ! alkal9e iodids8 ,did y make any comp>ative exp]im5ts & keep a record ( !m8 ,if s1 ! ref]ee w\ld l to receive an acc\nt ( y\r trials4 ,9 :at direction c\ld ,d be expect$ to occupy a sup]ior place 9 iod9 !rapy8 ,i hope t y c give ! in=mation ask$ by ! ref]ee & ?us aid ! ,c\ncil 9 arriv+ at a correct e/imate reg>d+ ! value ( ,d4 ,! foll[+ reply 0 receiv$ f ! physician 9 response to ! =ego+3 ,de> ,pr(essor ,puckn]3--,9 reply to y\rs ( ,janu>y #ai1 ,i did n proce$ f> en\gh 9 ! inve/igation ( ,d to draw conclusions ( any p>ticul> value = ! purpose ( ! ,c\ncil on ,ph>macy & ,*emi/ry2 & ,i s /at$ 9 my lett] to ! proprietors ( t rem$y4 ,answ]s to ! que/ions y put 9 y\r lett] require an am\nt ( inve/igation ( ! rem$y f> beyond any?+ ,i und]took4 ,z a matt] ( fact1 ,i return$ ab\t five six?s ( ! capsules s5t me1 because ( lack ( "t & opportunity to c>ry out ! ext5sive cl9ical exp]im5ts t ,i pla9ly saw w\ld be requir$ to give an op9ion at all wor? :ile4 ,i believe y _h bett] n consid] me 9 ! matt] at all4 ,! report 0 furni%$ by a physician = :om ,i h a high p]sonal reg>d4 ,i introduce x "h1 n s mu* 9 a _s ( criticism1 b z a ju/ification ( ! op9ion t ,i h =m$ ( cl9ical evid5ce obta9$ by manufactur]s ?r\gh _! cl9ical adjutors4 ,:5 comm]cial firms claim to base _! conclusions on cl9ical reports1 ! pr(ession has a "r to expect t ^! reports %\ld be submitt$ to compet5t & indep5d5t review4 ,:5 su* reports are kept secret1 x is impossible = any "o to decide :at proportion ( !m are tru/wor?y1 & :at proportion ?\ghtless1 incompet5t or accommodat+4 ,h[ev]1 if ?is 7 done x is q possible t su* firms w\ld f9d mu* m difficulty 9 obta9+ ! reports4 ,^? :o collaborate %\ld realize frankly t "u pres5t conditions !y are collaborat+1 n s mu* 9 det]m9+ ! sci5tific value1 b r 9 e/abli%+ ! comm]cial value ( ! article4 ,(t5 ! be/ type ( cl9ical reports--^? 9 :i* ! obs]vations are direct$ to ! significant ev5ts & n to m]e side l9es1 & 9 :i* ! significant ev5ts are correctly & adequately report$--g5]ally lack "o important ess5tial1 namely1 an adequate control ( ! natural c\rse ( ! disease4 ,s9ce ?is _c be controll$ directly1 x mu/ be comp5sat$ indirectly4 ,= ?is purpose1 !re are available two me?ods3 ,! fir/ is ! /ati/ical me?od1 9 :i* alt]nate pati5ts receive or d n receive ! treatm5t4 ,?is me?od c usually only be ( value :5 a v l>ge s]ies ( pati5ts is available4 ,ev5 !n1 its value is limit$ or d\btful1 because x _c take suffici5t acc\nt ( ! individuality ( cases4 ,! second me?od consi/s 9 ! attempt to di/+ui% unkn[n prep>ations by _! effects--! me?od t might be call$ ! 8comp>ative me?od0 or ! 8bl9d te/40 ,9 ?is1 ! pati5t1 or a s]ies ( pati5ts1 is giv5 ! prep>ation :i* is to be te/$1 & ano!r prep>ation :i* is inactive1 & ! obs]v] aims to di/+ui% ! two prep>ations by _! effects on ! pati5t4 ,surely if ! drug has any actions at all x w be possible to select correctly 9 a decid$ majority ( ! adm9i/rations4 ,! same pr9ciple c be appli$ 9 di/+ui%+ ! sup]iority ( "o prep>ation ov] ano!r4 ,9 ?is case1 ! two prep>ations w\ld be giv5 alt]nately to diff]5t pati5ts1 & ! obs]v] w\ld try to di/+ui% !m by _! effects4 ,"h aga91 if "o drug is really sup]ior or o!rwise diff]5t f ano!r1 to a practically important ext5t1 ! obs]v] w surely be able to make ! di/9ction4 ,?is me?od is really ! only "o t avoids ! pitfalls ( cl9ical obs]vation2 x is ! only me?od t makes ! results purely objective1 really indep5d5t ( ! bias ( ! obs]v] & ! pati5t4 ,x is ! only me?od1 !re=e1 :i* det]m9es :e!r x 0 really ! pudd+ t 0 eat5 & n "s o!r dess]t4 ,9 pr9ciple ?is me?od does n usually (f] any v great difficulties4 ,x is1 ( c\rse1 necess>y t ! two prep>ations to be comp>$ %all resemble ea* o!r s closely or %all be flavor$1 etc41 s t !y _c be di/+ui%$ by _! physical prop]ties4 ,?is is usually n a v difficult matt]4 ,! me?od does n jeop>dize ! int]e/s ( ! pati5t1 = x is und]/ood t no drug w\ld be te/$ 9 ?is way unless !re is "s reason to believe t x has a value4 ,:5 ! pati5t's condition is su* z to dem& treatm5t1 !n he w\ld be receiv+ ei!r ! /&>d drug or ! drug :i* ! exp]im5t] believes may be sup]ior to ! /&>d4 ,,conclusions ,! f9al & crucial te/ ( a rem$y is on ! pati5t2 b ! te/ mu/ be fram$ s z to make x really crucial4 ,mo/ cl9ical !rapeutic evid5ce falls f> %ort ( ?is4 ,! 8bl9d te/0 is urg$ to meet ! defici5cies4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,july #ba1 #aiag47 8,,vacc9es ,,9 ,,toxic ,,conditions0 ,comm]cializ$ ,propag&a 9 ! ,guise ( ,sci5ce ,"u ! title 8,vacc9es 9 ,toxic ,conditions10 :at purports to be a sci5tific contribution appe>s 9 ! orig9al dep>tm5t ( ! (ficial organ ( a /ate m$ical society4#caa ,! app>5t purpose ( ! article is to ov]come any hesitancy on ! "p ( practition]s to use vacc9es 9 toxic infecti\s conditions = fe> t !y might !reby cause h>m4 ,su* a !sis is int]e/+ & might be important--if true4 ,two out/&+ facts1 h[ev]1 give pause4 ,fir/1 ! !ory promulgat$ is contr>y to ! exp]i5ce ( ^? :o h /udi$ ! subject2 second1 ! man :o writes ! article is 9 ! bus9ess ( mak+ & sell+ vacc9es6 ,! =m] fact is a matt] ( fairly g5]al k among ! bett] in=m$ memb]s ( ! m$ical pr(ession2 ! latt] fact is n[h]e made evid5t 9 ! article1 :i* ! read] might inf] came f a dis9t]e/$ inve/igator 9 ! realms ( immunology4 #caa ,%]man1 ,g4 ,h43 ,vacc9es 9 ,toxic ,conditions1 ,ill9ois ,m4,j4 #ch3 #cad 7,oct47 #aibj4 ,! article purports to prove t ! special inve/igations c>ri$ on by its au?or %[ t !re is no basis = ! well-gr\nd$ fe> t vacc9es might be h>mful to a pati5t suff]+ f toxic infecti\s conditions4 ,?us3 ,f a clos] /udy ( ^! infective processes we f9d t ?is toxic condition is due to ! rapid multiplication ( ! infect+ organisms ) ! incid5tal production ( f]m5ts :i* ! g]ms secrete to dige/ ! food on :i* !y live4 ,^! toxic f]m5ts h a di/9ct de/ructive t5d5cy on tissue cells1 )\t any m>k$ influ5ce 9 /imulat+ tissue cells = antibody production4 ,! cry+ ne$1 h[ev]1 9 ^! ext5sive acute infections is rapid antibody =mation to neutralize ^! g]m-produc$ poisons & to elim9ate ! g]ms4 ,n[ vacc9es1 we are in=m$1 are n toxic & s /imulate ! production ( antibodies4 ,9 o!r words1 ! same organism t 9 ! body is toxic & )\t m>k$ antig5ic prop]ties becomes nontoxic & actively antig5ic :5 conv]t$ into a vacc9e4 ,! details ( ! exp]im5ts ( ! 8clos] /udy0 made by ! au?or ( ?is pap] 7& ! manufactur] ( vacc9es7 :i* give su* def9ite & conv9c+ results are n publi%$4 ,possibly ! article is a prelim9>y contribution1 & future issues ( ! same publication w c>ry fur!r articles on ! same subject4 ,! foll[-up sy/em is well recogniz$ 9 ! adv]tis+ _w4 ,at all ev5ts1 ?is 8clos] /udy0 has conv9c$ ! au?or ( ! article t3 444 ev5 9 extreme toxic conditions1 9 acute infections1 bact]ial vacc9es may be employ$ )\t ! lea/ fe> ( do+ any h>m4 ,9 fact1 we f9d t 9 extreme acute infections1 bact]ial vacc9es n only give ! be/ cl9ical results1 b !y may also be giv5 9 l>g] doses at %ort] int]vals ) less reactions ?an 9 m9or or *ronic infections & ! e>li] !y are giv5 ! bett] ! results4 ,"h aga9 no details are giv52 !re are no comp>ative results ( ! c>eful /udy ( a s]ies ( cases4 ,! sum & sub/ance ( ?is rem>kable contribution to a sci5tific publication is to ! effect 7#a7 t ! organism t 9 ! body is toxic becomes nontoxic :5 introduc$ 9 vacc9e =m2 7#b7 t ! organism t 9 ! body is b little antig5ic becomes :5 introduc$ 9 vacc9e =m actively antig5ic1 & 7#c7 t 89 extreme acute infections0 :5 ! body is affect$ pr(\ndly by ! infecti\s ag5t & its product1 ! (t5] & ! m "o injects ( ^! v mat]ials1 ! bett] ! results6 ,& ?is a/\nd+ plea = ! use ( vacc9es 9 conditions 9 :i* vacc9es are g5]ally held to be contra9dicat$1 or ev5 injuri\s1 is made by "o ^: bus9ess is ! manufacture ( vacc9es & sell+ !m to ! m$ical pr(ession6--7,editorial f ,! ,j\rnal ,a4 ,m4 ,a41 ,oct4 #bc1 #aibj47 ,,vitam9s3 ,,_! ,,di/ribution ,our k ( ! accessory food factors1 commonly spok5 ( z vitam9s1 is s rec5t1 comp>atively speak+1 & ! exact nature ( ^! factors /ill s envelop$ 9 my/]y1 t x 0 inevitable t ! public's lack ( k on ! subject %\ld be capitaliz$4 ,x is n surpris+ t !re are on ! m>ket a numb] ( prep>ations ( ! 8pat5t m$ic9e0 type t are be+ sold "u ! claim t !y are ri* 9 vitam9s--al?\gh ! exploit]s ( ^! fail to expla9 :i*1 if any1 ( ! ?ree accessory food factors _! products conta94 ,! r5aissance ( yea/ z a !rapeutic ag5t has giv5 an opportunity to ! manufactur]s ( ?is product ( unduly /ress+ ! fact t yea/ is p>ticul>ly ri* 9 ! ant9euritic vitam9 7wat]-soluble ,b74 ,because milk & c]ta9 milk products are ri* 9 ! fat-soluble ,a factor1 ! dairy int]e/s w\ld app>5tly h ! public believe t ?is p>ticul> vitam9 is to be obta9$ only f _! products4 ,?us1 a j\rnal devot$ to ! dairy int]e/s rec5tly claim$ t ^? :o want vitam9s mu/ get !m 9 _! milk1 butt]1 *eese & o!r milk products4 ,! tru? is1 ! accessory food factors are s well di/ribut$ ?r\gh\t ! diet>y ( mod]n man t1 g5]ally speak+1 ! individual :o uses ord9>y judgm5t 9 select+ 8 food is 9 no dang] ( suff]+ f a defici5cy ( any ( ^! ?ree factors4 ,x w\ld be well if e physician might read ! excell5t monograph on ! pres5t /ate ( k conc]n+ accessory food factors writt5 by a committee appo9t$ jo9tly by ! ,li/] ,in/itute & ,m$ical ,rese>* ,committee4 ,9 ?is report ! di/ribution ( ! vitam9s 9 our common food/uffs is ?us briefly summ>iz$3 8444 broadly speak+ x is safe to say t ! individual always f9ds suffici5t supply ( vitam9s 9 8 food s long z t food is reasonably v>i$ & has receiv$ no artificial or accid5tal sep>ation into p>ts1 & s long z no de/ructive influ5ce has be5 appli$ to x40 ,at ! end ( ! committee's report is a table 7reproduc$ on page #efb7 :i* %[s ! di/ribution ( ! ?ree accessory factors 9 ! common] food/uffs4--7,editorial f ,! ,j\rnal ,a4 ,m4 ,a41 ,aug4 #ac1 #aiba474 ,,di/ribution ,,( ,,?ree ,,accessory ,,factors ,,9 ,,common] ,,food/uffs ,classes ,fat-,soluble ,a ,wat]-,soluble ,b ,anti- ( or ,anti- or ,ant9euritic scorbutic ,food/uff ra*itic 7,antib]ib]i7 ,factor ,factor ,factor ,fats & ,oils3 ,butt] ,cream ,cod-liv] oil ,mutton fat ,beef fat or suet ,peanut oil ,fi% oil1 :ale oil1 etc4 ,m>g>9 prep>$ ,value 9 f animal fat proportion to am\nt ( animal fat conta9$ ,nut butt]s ,meat1 ,fi%1 etc43 ,lean meat 7beef1 mutton1 etc47 ,liv] ,kidneys ,he>t ,bra9 ,sweetbreads ,fi%1 :ite v slight1 if any ,fi%1 fat 7salmon1 h]r+1 etc47 v slight1 if any ,fi% roe ,cann$ meats 8 v slight ,milk1 ,*eese1 etc43 ,milk1 c['s :ole1 raw ,milk1 skim1 raw ,milk1 dri$ :ole less ?an less ?an ,milk1 boil$1 :ole undet]m9$ less ?an ,milk1 cond5s$1 sweet5$ less ?an ,*eese1 :ole milk ,eggs3 ,fre% 8 ,dri$ 8 ,c]eals1 ,pulses1 etc43 ,:eat1 maize1 rice1 :ole gra9 ,:eat g]m ,:eat1 maize1 bran ,l9se$1 millet ,dri$ peas1 l5tils1 etc4 ,soy beans1 h>icot beans ,g]m9at$ pulses or c]eals ,vegetables & ,fruits3 ,cabbage1 fre% 7raw7 ,cabbage1 fre% 7cook$7 ,cabbage1 dri$ v slight ,cabbage1 cann$ v slight ,sw$e 7rutabaga7 raw express$ juice ,lettuce ,sp9a* 7dri$7 ,c>rots1 fre% raw ,c>rots1 dri$ v slight ,beetroot1 raw1 express$ juice less ?an ,potatoes1 raw ,potatoes1 cook$ ,beans1 fre%1 sc>let runn]s1 raw ,onions1 cook$ at lea/ ,lemon juice1 fre% ,lemon juice1 pres]v$ ,lime juice1 fre% ,lime juice1 pres]v$ v slight ,orange juice1 fre% ,raspb]ries ,apples ,bananas v slight ,tomatoes 7cann$7 ,nuts ,miscellane\s3 ,yea/1 dri$ ,yea/1 extract & autolyz$ 8 ,malt extract 9 "s specim5s ,our ,k ( ,vitam9s ,comm5t+ on ! tr5d ( m$ical rese>* conc]n+ vitam9s1 ! late/ report ( ! ,briti% ,m$ical ,rese>* ,c\ncil says3 ,! pres5t situation is a curi\s "o1 ^u :i* po/]ity w probably look back ) great int]e/4 ,we /ill h almo/ no k ( ! nature ( ^! elusive food sub/ances or ( _! mode ( action1 b we h ga9$ empiric k already ( ! greate/ practical value = ! prev5tion ( scurvy & ( o!r grave diseases & = ! promotion ( heal? & beauty 9 ! population4 ,?is /atem5t1 x w be not$1 emphasizes ! f\ndation on :i* re/s our pres5t use ( vitam9s4 ,f "t to "t ,! ,j\rnal has comm5t$ on our lack ( actual k ( ^! my/]i\s sub/ances1 emphasiz+ p>ticul>ly ! g5]ally accept$ fact t ! tak+ ( a well-balanc$ diet results 9 provid+ ! individual ) su* vitam9s z are necess>y to 8 gr[? & nutrition4 ,la/ week appe>$ a brief report ( a meet+ ( ! ,*icago ,m$ical ,society devot$ to ?is subject1 & x 0 gratify+ to h ! cons]vative view :i* ,! ,j\rnal has emphasiz$ sub/antiat$ by _m ( ^? :o took "p 9 ! discussion4 ,moreov]1 ! ,briti% ,m$ical ,j\rnal1 9 its lead+ editorial = ,febru>y #aa1 reit]ates t an abundant supply ( vitam9s exi/s 9 all fre% vegetables1 & t a consid]able quantity occurs 9 milk & meat1 provid$ ! latt] sub/ances are obta9$ f animals f$ on fre% foods4 8,a normal adult10 x says1 8liv+ on an ord9>y diet conta9+ a reasonable proportion ( fre% vegetables is1 !re=e1 c]ta9 ( obta9+ a pl5tiful supply ( vitam9s40 ,( all ! mass ( evid5ce :i* has accumulat$ relative to ^! sub/ances1 ?is fact is ! po9t ( greate/ importance4 ,x is1 h[ev]1 v un=tunately1 ! "o po9t :i* ^? comm]cially incl9$ are unwill+ to recognize4--7,editorial f ,! ,j\rnal ,a4 ,m4 ,a41 ,m>* #aa1 #aibb47 ,! ,dem& = ,vitam9s ,?us ! ,briti% ,m$ical ,j\rnal 9 its curr5t issue3 ,9 spite ( ! fact t ord9>y fre% foods are ! simple/1 *eape/ & ri*e/ s\rces ( vitam9s1 ! public app>5tly dem&s to be suppli$ ) vitam9s 9 ! =m ( m$ic9al products4 ,! public 8dem&s0 vitam9s 9 pill =m6 ,:y8 ,= ! same reason t ! public1 lay or m$ical1 dem&s _m ?+s today t x does n ne$--because ! :ole tr5d ( mod]n adv]tis+ is t[>d creat+ dem&s1 r ?an supply+ ne$s4 ,vitam9 conc5trates are be+ 8dem&$0 by ! public because %rewd & =w>d-look+ 8pat5t m$ic9e0 exploit]s are us+ all ! subtle arts ( mod]n adv]tis+ to conv9ce ! public t x is 9 s]i\s dang] ( vitam9 />vation1 & t ! only hope lies 9 buy+ ^! alleg$ conc5trates to make up a hypo!tical defici5cy4 ,x seems inconceivable t a rational man w\ld pay a trem5d\sly high price = c]ta9 food factors :i* are already pres5t 9 8 ord9>y diet4 ,b he w2 & adv]tis+ is ! reason4 ,adv]tis+ campaigns su* z ^! ( ! vitam9s con/itute a vici\s circle2 an artificial dem& is creat$ & !n ! manufactur] excuses 8 bus9ess on ! gr\nd t he is m]ely supply+ a dem&6 ,z our ,briti% contempor>y says1 8ord9>y fre% foods are ! simple/1 *eape/ & ri*e/ s\rces ( vitam9s40--7,editorial f ,! ,j\rnal ,a4 ,m4 ,a41 ,m>* #ah1 #aibb47 ,,! ,,william ,a4 ,,web/] ,,co4 ,,& ,,! ,,direct ,,ph>maceutical ,,co4 ,! foll[+ lett] f a ,detroit physician 0 receiv$ a few days ago4 ,to ! ,editor3--,i h j receiv$ a lett] f ! ,direct ,ph>maceutical ,co4 ( ,/4 ,l\is1 ,mo41 quot+ prices on drugs :i* are n m ?an "o half :at ! lead+ manufactur]s are quot+ on ! same drugs4 ,i h receiv$ previ\s lit]ature f ?is company b h n done bus9ess ) !m4 ,i w\ld be unwill+ to prescribe _! drugs unless ,i 7 satisfi$ t !y are :at is claim$ = !m4 ,i w\ld be glad to receive any in=mation reg>d+ ?is firm t may be available4 ,! ,j\rnal has also receiv$ "s lett]s f physicians reg>d+ ! ,william ,a4 ,web/] ,co4 ( ,memphis1 ,t5n41 relative to a lett] ! conc]n 0 s5d+ physicians 9 ! =m ( a te/imonial 7reproduc$ 9 m9iature on ?is page7 & alleg$ to be f ,dr4 ,f4 ,w4 ,p4 ,butl] ( ,columbia1 ,s4 ,c4 ,typical lett]s on ! ,web/] adv]tis+ foll[3 ,to ! ,editor3--,is !re n "s way ?r\gh :i* ! dignity ( ! m$ical pr(ession c be protect$ f ! circulation ( su* idiotic drivel z ! enclosures display8 ,to ! ,editor3--,i am s5d+ y an example ( ! sort ( 8evid5ce0 :i* "s s-call$ e?ical ph>maceutical h\ses expect physicians to take = sci5tific pro(4 ,x is pa!tic t !re are "s 9 our pr(ession :o 8fall =0 su* rot4 ,i tru/ y w cont9ue y\r campaign = hone/ & intellig5t m$ic9e4 ,! 8evid5ce0 to :i* "o ( ! correspond5ts ref]s & :i* ano!r *>act]izes z 8idiotic drivel0 is reproduc$ on ! foll[+ page 9 m9iature4 ,x is a te/imonial = ,william ,a4 ,web/] ,company's 8,f]ritonic-,woods40 ,our read]s may wond] :y we are discuss+ 9 "o article ! ,william ,a4 ,web/] ,company ( ,memphis1 ,t5n41 & ! ,direct ,ph>maceutical ,co4 ( ,/4 ,l\is4 ,! reason is t ! ,direct ,ph>maceutical ,co4 ( ,/4 ,l\is is app>5tly m]ely a sales ag5cy = ! ,william ,a4 ,web/] ,company ( ,memphis4 ,x appe>s t ord]s s5t 9 to ! ,direct ,ph>maceutical ,co4 g to ,memphis to be fill$4 ,! foll[+ in=mation reg>d+ "s ( ! products t h 9 ! pa/ be5 put out by ! ,william ,a4 ,web/] ,company %\ld be ( int]e/ to ! pr(ession4 ,9 gov]nm5t bullet9s issu$ by ! ,dep>tm5t ( ,agriculture 9 ,octob]1 #aiac1 !re 7 report$ "s cases ( adult]ation & misbr&+ on ! "p ( ! ,william ,a4 ,web/] ,co41 ( ,memphis1 ,t5n4 ,a 8,pure ,conc5trat$ ,extract ( ,lemon0 %ipp$ by ?is conc]n 0 f\nd by ! f$]al *emi/s to be color$ ) a coal-t> dye 8:]eby inf]iority 0 conceal$10 & :ile purport+ to be a conc5trat$ lemon extract1 89 fact1 x 0 n a conc5trat$ lemon extract40 ,"s 8,pure ,conc5trat$ ,extract ( ,banana0 0 f\nd to h mix$ ) x an imitation banana flavor & an artificial color s z to 8injuri\sly affect its quality & /r5g?0 & s t 8its inf]iority 0 conceal$40 8,pure ,conc5trat$ ,extract ( ,p9eapple0 0 f\nd to h _h mix$ ) x 8an imitation extract ( p9eapple artificially color$40 8,pure ,conc5trat$ ,extract ( ,/rawb]ry0 _h be5 mix$ ) 8an imitation /rawb]ry extract artificially color$40 ,! same bullet9s describ$ ! case ( ! gov]nm5t aga9/ a %ipm5t ( 8,syrup ,iron ,iodide0 made by ! ,web/] conc]n 9 :i* ! am\nt ( iron iodid 0 less ?an half t claim$ on ! label4 ,9 ea* ( ! cases j describ$1 ! company plead$ guilty & 0 f9$4 ,illu/ration3 ,reproduction 7r$uc$7 ( a te/imonial lett] s5t to physicians by ,william ,a4 ,web/] ,company ( ,memphis1 ,t5n4 ,^? :o op]ate ?is conc]n also h a sales ag5cy 9 ,/4 ,l\is1 ,mo41 kn[n z ! ,direct ,ph>maceutical ,co4 ,9 a simil> bullet9 issu$ ,augu/1 #aiad1 !re 7 record$ sev]al m cases ( adult]ation & misbr&+ *>g$ aga9/ ! ,william ,a4 ,web/] ,company4 ,"s 8,w9e ,coca ,leaves0 0 held adult]at$ 9 t ! am\nt ( alcohol pres5t 0 wrongly decl>$ on ! label2 x 0 held misbr&$ 9 t :ile x conta9$ coca91 ! label fail$ to be> any /atem5t reg>d+ ! quantity ( proportion ( ?is drug4 ,tablets ( 8,acetanilid & ,sodium ,bromid ,comp\nd0 7 f\nd defici5t 9 /r5g?4 8,anti-,vomit ,tablets10 8,aspir9 ,tablets10 8,bismu? & ,calomel ,tablets10 8,qu99 ,laxative ,tablets10 8,salol ,tablets10 8,sodium ,salicylate ,tablets10 8,neuralgic ,tablets10 8,di>rhea ,calomel ,pills0 & 8,morph9 ,sulphate ,hypod]mic ,tablets0 7 also misbr&$ 9 t ! am\nt ( c]ta9 +r$i5ts f\nd 9 !m fail$ to tally ) ! am\nt decl>$ on ! label4 ,9 all ( ^! cases also ! ,william ,a4 ,web/] ,company plead$ guilty & 0 f9$4 ,9 a gov]nm5t bullet9 issu$ 9 ,june1 #aiag1 ! same company 0 *>g$ ) adult]at+ & misbr&+ a quantity ( ,aspir9 tablets :i*1 in/ead ( conta9+ #e gra9s z label$1 conta9$ only a fraction ov] #a gra94 ,9 ?is case1 too1 ! company plead$ guilty & 0 f9$4 ,! table t foll[s briefly summ>izes "s ( ! cases j ref]r$ to3 ,am\nt ,claim$ ,am\nt ,f\nd 8,syrup ,iron ,iodid1 ,u4 ,s4 ,p40 ,f]r\s ,iodid #aj #d4f 8,acetanilid & ,sodium ,bromid ,tablets0 ,acetanilid #c4ej gr4 #b4id gr4 8,anti-,vomit ,tablets0 ,bismu? subnitrate #b4ej gr4 #a4gf gr4 ,c]ium ,oxalate #b4ej gr4 #a4gh gr4 ,coca9 ,hydro*l4 #j4jhcc gr4 #j4jfcg gr4 8,aspir9 ,tablets0 #e4j gr4 #c4hb gr4 8,bismu? & ,calomel ,comp4 ,tablets0 ,bismu? subnitrate #j4a gr4 #j4bb gr4 ,calomel #j4a gr4 #j4bb gr4 8,qu99 ,laxative ,tablets0 ,acetanilid #b4j gr4 #a4fi gr4 8,salol ,tablets0 #b4ej gr4 #b4je gr4 8,sodium ,calicylate ,tablets0 #e4j gr4 #c4hh gr4 8,neuralgic ,pills0 ,morph9 sulphate #j4je gr4 #j4jae gr4 8,di>rhea ,calomel ,pills0 ,morph9 sulphate #j4jfb gr4 #j4je gr4 8,morph9 ,sulphate ,hypod]mic ,tablets0 #j4be gr4 #j4ba gr4 8,aspir9 ,tablets0 #e4jj gr4 #a4ac gr4 ,x_/ --7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,oct4 #ah1 #aiai47 ,,yea/ ,f "t to "t yea/ has atta9$ a transitory popul>ity z a !rapeutic ag5t4 ,its use 9 ?is way 9 practical m$ic9e has be5 bas$ ess5tially on empiric consid]ations4 ,yea/ is ri* 9 nucleic acid1 b ?is has n f\nd any special applications4 ,! fatlike sub/ances obta9able f yea/ h be5 recomm5d$ 9 c]ta9 alim5t>y conditions1 )\t f9d+ any widespread acceptance4 ,m rec5tly yea/ has acquir$ int]e/ f some:at diff]5t angles4 ,9 ^! days ( food %ortage & en=c$ cons]vation1 x has come to be realiz$ t ! m9ute yea/ cells are end[$ ) a rem>kable capacity ( syn!siz+ "o ( ! mo/ valu$ nutri5ts1 namely1 prote94 ,?is sub/ance c be built up out ( ! simple/ =ms ( nitrog5\s comp\nds by yea/s1 9 contra/ ) ! incapacity ( ! high] organisms to con/ruct prote9 out ( any?+ less complex ?an ! ready made am9oacids4 ,x is report$ t 9 ,europe yea/ has actually be5 gr[n on a l>ge scale 9 solutions ( sug>1 salt & simple nitrog5\s comp\nds = ! sake ( secur+ ! mu* desir$ prote9s4 ,! utilization ( yea/ prote9 = cattle fe$+ is a curr5t practice abroad2 & ! satisfactory dige/ibility & availability ( ! same product by ! human organism has repeat$ly be5 ann\nc$ s9ce ! beg9n+ ( ! w>4 ,9 ?is c\ntry ! yea/ :i* is produc$ z a by-product ( ! brew+ indu/ry is = ! mo/ "p disc>d$ z wa/e2 9 ! di/ill]ies x becomes a "p ( ! di/ill]s' gra9s t are ext5sively employ$ z fe$s 9 ! dairy indu/ry4 ,/ill new] is ! indication t yea/ is comp>atively ri* 9 at lea/ "o ( ! z yet unid5tifi$ accessory factors 9 nutrition n[ popul>ly spok5 ( z vitam9s4 ,hopk9s ( ! ,univ]sity ( ,cambridge1 ,engl&1 fir/ direct$ att5tion to ?is unique prop]ty ( yea/4 ,x has be5 v]ifi$ by ,funk & ,macallum1 & rec5tly ,osborne & ,m5del h giv5 sub/antial evid5ce ( ! pot5cy ( yea/ to r5d] a diet n o!rwise capable ( induc+ ma9t5ance effective 9 nutrition4 ,yea/ has be5 us$1 l extracts ( rice poli%+s1 to cure ! exp]im5tal polyneuritis induc$ 9 birds by a diet ( poli%$ rice4 ,f ! exp]im5ts ( ,osborne & ,m5del x appe>s t less ?an #b p] c5t4 ( dri$ brew]s' yea/ suffices to induce small exp]im5tal animals to gr[ on artificial food mixtures on :i* alone !y fail to ?rive4 ,h[ ! use ( yea/ z an adjuvant to o!rwise inadequate food mixtures ex]ts its b5eficial effect is n yet made cle>4 ,satisfactory gr[? 9 ^! cases is promot$ by lib]al eat+4 ,any?+ :i* r5d]s food m palatable may /imulate "o to eat m lib]ally ( x4 ,?is c sc>cely be ! explanation ( ! pot5cy ( ! yea/ z x is effective ev5 :5 f$ ap>t f ! re/ ( ! food4 ,x may h a favorable effect on ! metabolism & ?us improve ! g5]al condition s t m food is consum$4 ,small quantities ( milk & extracts ( _m ( ! common plant foods1 su* z ! c]eal gra9s1 h be5 f\nd to act 9 ! same way4 ,!re seems to be little d\bt1 !re=e1 t yea/ also conta9s some?+ comp>able ) ! s-call$ wat]-soluble vitam9s ( ! diet4 ,a specific ne$ = yea/ c sc>cely be pr$icat$ on ?is fact1 h[ev]2 = any well select$ human diet>y conta9+ ! usual v>iety ( animal & vegetable foods is n likely to be devoid ( ! widely di/ribut$ wat]-soluble type ( vitam94 ,we m5tion ?is to *eck premature en?usiasm = a new vitam94--7,editorial f ,! ,j\rnal ,a4 ,m4 ,a41 ,sept4 #h1 #aiag47 ,yea/ & ,its ,uses ,to ! ,editor3--,is !re available in=mation conc]n+ ! m$ic9al use ( yea/8 ,h[ is x tak58 ,i %\ld l to "k :e!r ! use ( x w\ld cause any dige/ive di/urbance1 & :e!r ! fle% ga9$ is normal & p]man5t4 ,s4 ,e4 ,l41 ,bridgeport1 ,conn4 ,,answ]4--,yea/ is "o ( ^? rem$ies t h und]gone alt]nat+ cycles ( use & ( disuse2 j at pres5t x appe>s aga9 to be 9 its asc5d5cy4 ,no d\bt1 ! reason = ^! cycles has be5 excessive praise & uncritical use1 foll[$ by disappo9tm5t & consequ5t disc>d4 ,hawk & 8 associates 7,hawk1 ,p4 ,b42 ,kn[les1 ,f4 ,c42 ,rehfuss1 ,m4 ,e41 & ,cl>ke1 ,j4 ,a43 ,! ,use ( ,bak]s' ,yea/ 9 ,diseases ( ! ,sk9 & ( ! ,ga/ro-,inte/9al ,tract1 ,! ,j\rnal1 ,oct4 #ac1 #aiag1 p4 #abdc7 h rec5tly call$ r5ew$ att5tion to its laxative qualities4 ,:5 f "o-half to "o cake ( yea/ 0 giv5 ?ree times daily be=e meals1 x produc$ regul> b[el movem5ts 9 a numb] ( pati5ts suff]+ f con/ipation4 ,t ?is result is n due to any vital processes 9 ! yea/ is %[n by ! fact t yea/ kill$ by boil+ wat] 0 employ$ ) success4 ,x is sugge/$ t su* yea/ might be pref]r$ = pati5ts tr\bl$ ) flatul5ce4 ,aside f ! t5d5cy ( liv+ yea/ to produce di>rhea1 & ! possibility t x may aggravate flatul5ce1 no dige/ive di/urbance has be5 *>g$ aga9/ x4 ,a>on1 9 8 8,diseases ( ! ,dige/ive ,organs10 speaks favorably ( its use 9 atonic con/ipation4 ,! mu* debat$ "q :e!r yea/ may s]ve z a food c be answ]$ 9 ! affirmative 9 view ( su* "w z t ( ! ,g]mans on 8,nhrhefe0--yea/ food 7,s*ottelius1 ,deuts*4 m$4 ,w*ns*r41 ,july #h1 #aiae1 p4 #hag7 & ,boruttau 7ibid41 ,july #bi1 #aiae1 p4 #ibd7 & ( ,hawk & 8 associates4 ,!re is no reason to assume t weight ga9$ "u its use w\ld be m readily lo/ ?an weight ga9$ f any o!r food4 ,h[ev]1 9 view ( its laxative action1 ! av]age individual c +e/ only f #a to #b gm4 ( nitrog5 a day 9 ?is =m4 ,?is obvi\sly greatly limits its value z a food4 ,ow+ to its high nucle9 cont5t1 x is contra9dicat$ 9 g\t4 ,z a s\rce ( wat] soluble gr[? promot+ z well z ant9euritic vitam91 yea/ has become ?or\ghly e/abli%$ z ! result ( ! rec5t works ( num]\s inve/igators4 ,h[ev]1 z su* common foods z milk1 rice1 :eat1 oats & beans also conta9 su* vitam91 !re is little likelihood ( its prov+ ( !rapeutic value on t acc\nt4 ,9 o!r words1 yea/ & o!r vitam9 conta9+ foods h specific gr[? promot+ qualities only :5 ! /unt+ is due to lack ( vitam94 ,a m9ute am\nt ( ?is sub/ance suffices to produce maximal results4 ,m is ( no use4 ,hess 7,proc4 ,soc4 ,exp]4 ,biol4 ,m$4 #ac3ade1 #aiaf7 f\nd yea/ ( no value 9 infantile scurvy4 ,! mo/ important "q 9 connection ) yea/ !rapy is to :at ext5t x is end[$ ) 8antibiotic0 p[]1 t is1 to :at degree x is capable ( inhibit+ ! gr[? ( o!r organisms4 ,t ?is frequ5tly occurs 9 cultures 9 vitro is %[n by ! fact t yea/ contam9ation may practically eradicate ! gr[? ( c]ta9 o!r organisms4 ,t1 on ! o!r h&1 ?is is n true = all =ms ( bact]ial life is %[n by ! fact t !re is def9ite symbiosis betwe5 yea/ & lactic acid bacilli 7,nor?rup3 ,soc4 ,te*4 ,bull4 #ae1 ,mi*4 ,agr4 ,expa4 ,/a41 #aiab74 ,t its 8antiseptic p[] is1 on ! :ole insignificant0 has be5 %[n by ,pali] 7,diet4 ,hyg4 ,gaz41 ,m>*1 #aijf71 :o f\nd comm]cial yea/s commonly contam9at$ ) num]\s bact]ia1 ! mo/ frequ5t be+ ,bacillus coli-communis or "o ( its cong5]s4 ,an antagoni/ic action by yea/ is claim$ aga9/ ,/aphylococcus pyog5es1 & on ! /r5g? ( ?is1 ,bu*holtz 7,ueb] ,acne und e9e neue erfolgrei*e ,beh&lung d]selb51 ,b]l4 kl94 ,w*ns*r41 ,feb4 #b1 #aiad1 p4 #bae7 employ$ x locally 9 ! treatm5t ( acne & obta9$ a positive b tempor>y effect4 ,he believes t ! effect is improv$ by ! comb9ation ( yea/ ) an equal quantity ( boric acid4 ,he employ$ ?is z a du/+ p[d] appli$ freely to ! sk9 once daily1 aft] ! application ( a ?9 lay] ( a boric acid salve 7boric acid p[d] f #dj to #ej1 glyc]9 & wat]1 ( ea* #ajj7 to make x /ick bett]4 ,9 cases 9 :i* ! nose 0 m>k$ly involv$1 he also us$ ?is z a snuff4 ,yea/ p\ltices h be5 employ$ ) ass]t$ great b5efit 9 ! treatm5t ( w\nd infection ( all k9ds 7,kempf1 ,e4 ,j43 ,ind4 ,m4 ,j41 ,septemb]1 #aijd1 p4 #ig74 ,! use 9 leukorrhea 0 recomm5d$ by ,hippocrates ,abraham 7,mon4 ,geb4 ,sym41 #aiaj7 & _m o!rs report favorable results f yea/ 9 ! treatm5t ( gonorrheal vag9itis4 ,9 v>i\s ga/ro-inte/9al infections1 yea/ has be5 laud$ by _m1 among o!rs1 ,?i]cel9 & ,*evrey4 ,x has be5 giv5 by m\?1 b mo/ especially 9 high rectal enemas4 ,/ill m f a !oretical /&po9t is ! reass]tion ( ! curative value ( ! oral adm9i/ration ( yea/ 9 v>i\s cutane\s disord]s4 ,?us ,hawk & 8 collaborators report cure or improvem5t 9 all ( sev5te5 cases ( acne vulg>is & eight cases ( acne rosacea4 ,!y also report sev5te5 cases ( furunculosis1 9 all b "o ( :i* !re 0 cure or improvem5t f yea/ treatm5t4 ,!y are unable to decide :e!r ! result is due to ! laxative action1 ! production ( leukocytosis1 or to o!r influ5ces4 ,yea/ is probably be/ tak5 incorporat$ 9 food4 ,hawk & 8 associates f\nd t yea/ may well be incorporat$ 9 :eat biscuits1 & t 9 ?is way a yea/-:eat comb9ation ( mo/ agreeable flavor 0 produc$3 t1 9 fact1 ! biscuits ) ! yea/ ta/$ bett] ?an ^? )\t x4 ,!y f\nd by te/s t 9 bread mak+ z mu* z #bj p] c5t4 ( ! fl\r might be replac$ by dry yea/1 & t !reby a loaf w\ld be produc$ t 0 excell5t 9 e way & possess$ ( an attractive flavor4 ,! dry yea/ 0 prep>$ by desiccat+ compress$ yea/ at #aje ,c4 9 a curr5t ( air1 & !n mill+ x to produce a fl\r ( ! approximate f95ess ( ord9>y :eat fl\r4 ,!y also f\nd t yea/ may be add$ to meat prep>ations1 su* z ,hamburg] /eak1 to ! ext5t ( #b4e p] c5t41 yield+ a prep>ation ( v satisfactory ta/e4--7,qu]y 9 ,! ,j\rnal ,a4 ,m4 ,a41 ,aug4 #bc1 #aiai47 ,,brief] ,,p>agraphs ,laxol & ,lysol--,! ,%ort & ,cat*y ,propriet>y ,"n ,a labor] w5t to a ,brooklyn physician = treatm5t & 0 giv5 ?ree prescriptions4 ,"o ( ! prescriptions1 accord+ to ! ,food & ,drug ,bullet9 ( ! ,dep>tm5t ( ,heal?1 ,city ( ,new ,york1 call$ = 8,laxol10 ! ^w be+ writt5 on a piece ( blank pap] )\t directions4 ,! drug cl]k misread ! prescription & disp5s$ an 8orig9al0 bottle ( 8,lysol0 :i* bore ! usual poison label ) skull & cross bones4 ,! man drank ! entire #c ounces ( ,lysol & di$ half an h\r lat]4 ,! case is n[ 9 ! h&s ( ! ,di/rict ,attorney1 ! drug cl]k be+ held "u #aj1jjj bail4 8,laxol10 z our read]s "k1 is ca/or oil sweet5$ ) sac*>9 & flavor$ ) pepp]m9t4 ,!re is no excuse = prescrib+ ! product4 ,! (ficial ,aromatic ,ca/or ,oil 7,ol4 ,ric94 ,arom47 ( ! ,national ,=mul>y w\ld answ] e purpose s]v$ by ! propriet>y prep>ation4--7,editorial f ,! ,j\rnal ,a4 ,m4 ,a41 ,may #bi1 #aibj47 ,look ,up ,its ,rat+ ,mod]n bus9ess has become s complex t x is no long] possible = ^? engag$ 9 trade to "k1 (fh&1 ! f9ancial responsibility ( _! prospective cu/om]s4 ,! comm]cial ag5cy is a natural developm5t2 x aims to supply ! te*nical 7f9ancial7 in=mation :i* ! cons]vative bus9ess man ne$s b is o!rwise unable to get4 ,:5 ,john ,doe ,co4 contemplates ent]+ into bus9ess arrangem5ts ) ,h5ry ,roe ,son to a degree t involves f9ancial obligations1 x looks up ,roe 9 ! rat+ book ( ,dun or ,brad/reet & probably calls = a special comm]cial report on ! conc]n4 ,^! facts are s elem5tal & obvi\s z to be trite4 ,! complexity ( mod]n m$ic9e1 especially 9 ! ph>macologic field1 has made x a physical impossibility = physicians to "k ! sci5tific /atus ( scores ( ph>maceutical products put out "u propriet>y or br& names4 ,x 0 recognition ( ?is fact t br\ght ab\t ! creation by ! ,am]ican ,m$ical ,association ( ! ,c\ncil on ,ph>macy & ,*emi/ry4 ,?is body ( exp]ts1 s]v+ )\t remun]ation & report+ )\t fe> or favor on ! newcom]s to ! ph>maceutical _w1 places at ! disposal ( physicians unbias$ in=mation1 free alike f prejudice or prepossession4 ,z ! comm]cial ag5cy reports on ! comm]cial probity ( individuals & firms1 s ! ,c\ncil on ,ph>macy & ,*emi/ry reports on :at might be call$ ! sci5tific probity ( propriet>y & un(ficial ph>maceutical products4 ,! comm]cial ag5cy issues1 at no small exp5se to its cu/om]s1 rat+ books2 ! c\ncil on ,ph>macy & ,*emi/ry issues1 at a nom9al price1 8,new & ,non(ficial ,rem$ies40 ,! comm]cial ag5cy1 = a sub/antial fee1 w furni% reports on bus9ess conc]ns2 ! ,c\ncil on ,ph>macy & ,*emi/ry w1 )\t any exp5se to ! pr(ession1 furni% reports on propriet>y products us$ = ! relief or cure ( human ailm5ts4 ,! c>eful bus9ess man avails himself ( ! s]vices ( ! comm]cial ag5cy2 !re are f9ancial int]e/s at /ake4 ,! consci5ti\s physician w avail himself ( ! s]vices ( ! ,c\ncil2 !re are1 x may well be1 lives at /ake4--7,editorial f ,! ,j\rnal ,a4 ,m4 ,a41 ,april #bd1 #aibj47 ,! ,m$ical ,pr(ession & ,comm]cial ,int]e/s ,la/ week ,! ,j\rnal publi%$ a lett] receiv$ by a physician 9 ,milwaukee f a firm ( lawy]s repres5t+ ! ,f>bw]ke-,hoe*/ ,company4 ,9 ?is communication ! physician 0 ?reat5$ ) suit if he publi%$ fur!r unfavorable reports reg>d+ t firm's prep>ation4 ,quot+ f ! attorney's lett]3 8,mr4 ,metz directs u to in=m y t ! publication ( ?is article & ! /atem5ts !re9 7 s]i\sly damag+ to ! ,f>bw]ke-,hoe*/ ,company1 & directs u to say fur!r to y t he & ! corporation w hold y p]sonally responsible = any repetition1 oral or writt51 ( ! same or ( simil> /atem5ts to ! same effect40 ,we 7 "u ! impression t ! "t _h pass$ :5 a propriet>y m$ic9e manufactur] w\ld presume to ?reat5 a physician = mak+ an hone/ report ( 8 results ) any !rapeutic ag5t4 ,su* condition did exi/ once1 be=e ! ,c\ncil on ,ph>macy & ,*emi/ry und]took its "w4 ,n[ comes ,mr4 ,metz to revive ?is relic ( an hi/oric b infam\s p]iod 9 ! hi/ory ( ,am]ican propriet>y m$ic9e manufactur+4 ,ev5 ,mr4 ,v&]bilt regrett$ t he ev] said 8,! public be d----40 ,"o ( ! elem5t>y pr9ciples 9 ! practice ( m$ic9e is t ! individual physician %all let o!rs "k 8 results1 :e!r good or bad1 9 any l9e ( treatm5t4 ,x is by su* int]*ange ( k & exp]i5ce t progress 9 m$ic9e is possible4 ,yet ,mr4 ,metz w\ld int]f]e ) ! diffusion ( su* k & exp]i5ce :5 x applies to propriet>y m$ic9es4 ,8 legal ?reat aga9/ ,dr4 ,s>g5t is 8t]rorism0 appli$ to ! m$ical pr(ession4--7,editorial f ,! ,j\rnal ,a4 ,m4 ,a41 ,june #h1 #aiah47 ,rabbit-,foot ,!rapy ,few b ignorant d>kies h any great fai? 9 ! !rapeutic efficacy ( ! left h9d foot ( a rabbit caught 9 ! *ur*y>d 9 ! d>k ( ! moon4 ,9 ! light ( mod]n !rapeutics "o is tempt$ to believe1 h[ev]1 t _h "s "o p]son or firm an exclusive propriet>y "r to ?is p>ticul> br& ( rabbits' feet1 !re w\ld be _m intellig5t p--& n all ( !m laym5--ready to swe> by rabbits' foot !rapy4 ,9 m$ical j\rnals 7^: adv]tis+ pages set =? ! virtues ( ! p$al extremities ( ,lepus sylvaticus7 _m solemnly sci5tific articles w\ld probably appe> relat+ ! success t ! writ]s _h _h ) ?is =m ( !rapy 9 ! treatm5t ( "s di/ress+ /ubborn conditions t _h fail$ to respond to all previ\s ef=ts4 ,is x ubiquity t has sav$ ! homely cotton-tail f be+ a !rapeutic h]o8--7,editorial f ,! ,j\rnal ,a4 ,m4 ,a41 ,sept4 #bi1 #aiag47 ,secret ,rem$ies & ! ,pr9ciples ( ,e?ics ,_m hundr$s1 possibly ?\s&s1 ( inquiries are receiv$ ea* ye> by ,! ,j\rnal f physicians ask+ = in=mation on1 or an op9ion ( c]ta9 propriet>y rem$ies4 ,9 _m in/ances ! prep>ations 9 "q are ess5tially secret 9 composition1 al?\gh adv]tis$ to ! pr(ession "u a fair-seem+ ext]ior ( app>5t frankness4 ,!re are on ! m>ket today--& us$ by memb]s ( ! ,am]ican ,m$ical ,association--doz5s1 yes scores1 ( widely adv]tis$ propriet>ies t are1 to all int5ts & purposes1 secret4 ,! physicians :o prescribe !m d n "k & _c "k :at !y are giv+ _! pati5ts4 ,on ?is po9t ,section #f ( ,*apt] ,,ii ( ! ,pr9ciples ( ,m$ical ,e?ics ( ! ,am]ican ,m$ical ,association says3 8444 x is 444 une?ical to prescribe or disp5se secret m$ic9es or o!r secret rem$ial ag5ts1 or manufacture or promote _! use 9 any way40 ,! inh]5t & basic reasonabl5ess ( ! v>i\s requirem5ts ( ! ,pr9ciples ( ,m$ical ,e?ics ne$s no exposition or def5se4 ,a l>ge numb] ( propriet>y rem$ies :i* at pres5t degrade m$ic9e w\ld be wip$ out ( exi/5ce or1 at any rate1 g ov] to ! 8pat5t m$ic9e0 class1 :]e !y belong1 if physicians w\ld live up to ,section #f1 ,*apt] ,,ii1 ( ! ,pr9ciples4--7,editorial f ,! ,j\rnal ,a4 ,m4 ,a41 ,sept4 #bg1 #aiai47 8,/]l+ ,violet ,ray ,g5]ator0 ,to ! ,editor3--,i am curi\s to le>n ! value ( ! violet ray 9 ! treatm5t ( disease4 ,! violet ray seems to be mu* 9 evid5ce 9 ,canada at ! pres5t "t 9 v>i\s t[ns4 ,x is well adv]tis$1 n 9 ! same way z a 8pat5t m$ic9e0 w\ld be1 b z a g5u9e =m ( treatm5t4 ,! enclos$ booklet gives a brief outl9e ( :at ! ag5ts = ! 8,/]l+ ,violet ,ray ,g5]ator0 claim x w d4 ,! reason ,i am tr\bl+ y ab\t ! matt] is t ,i feel if !re is any?+ 9 x z is claim$1 x %\ld be bett] kn[n4 ,x also seems t if ?is treatm5t is n capable ( do+ :at is claim$ = x1 x is a r s]i\s ?+ = a p]son :o may def] call+ a physician4 ,j4 ,a4 ,g4 ,,answ]4--,! 8,/]l+ ,violet ,ray ,g5]ator0 is a small high frequ5cy app>atus ) "s vacuum & possibly o!r electrodes4 ,!re is a violet color 9 ^! vacuum electrodes :5 !y are en]giz$4 ,! app>atus is n "o = produc+ violet or ultraviolet rays 9 ! sci5tific mean+ ( ^? words4 ,! app>atus c]ta9ly w n d ! ?+s claim$ = x 9 ! booklet :i* includes ! treatm5t ( practically e ailm5t kn[n to mank9d4--7,correspond5ce 9 ,! ,j\rnal ,a4 ,m4 ,a41 ,april #ad1 #aiag47 ,/rontium ,salicylate ,n ,sup]ior to ,sodium ,salicylate ,sodium salicylate is a valuable drug4 ,x is (ficial & *eap2 x is ! comp\nd g5]ally reli$ on :5 salicylate effects are desir$4 ,& !re is no my/]y ab\t x4 ,) ! o!r salicylates1 my/]y beg9s4 ,= ?is reason1 su* /udies z t ( ,blank5horn on /rontium salicylate are ( special value4 ,blank5horn %[s t /rontium salicylate possesses no advantages ov] sodium salicylate1 z reg>ds ei!r !rapeutic efficacy or fre$om f undesirable by-effects4 ,he calls att5tion to ! fact t 8! salicyl cont5t ( /rontium salicylate is ab\t f\r-fif?s t ( sodium salicylate bas$ on ! am\nt ( available anion40 ,! "q naturally arise :e!r ?is small] salicylate cont5t may n contribute to ! notion t /rontium salicylate is less likely to cause salicylism4 ,! impression z to ! great] fre$om ( ?is salt f undesirable by-effects may h aris5 9 "p also f ! fact t ! m exp5sive prep>ations are m likely to be giv5 9 small doses ?an is ! *eap] sodium salicylate4 ,z ,blank5horn sugge/s1 :5 once su* a tradition ga9s curr5cy1 x w be 8lugg$ along0 f "o textbook to ano!r1 ) little or no attempt at critical exam9ation4--7,editorial f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #bi1 #aiaf47 ,vacc9e ,z a ,prophylactic 9 ,influ5za ,to ! ,editor3--,i am *ief surgeon = a l>ge /eel indu/ry 9 ,canton1 & desire to d all 9 my p[] to prev5t ! ?reat5$ recurr5ce ( influ5za4 ,:at is ! /atus ( ! v>i\s vacc9es z a prev5tive or prophylactic measure8 ,w\ld y advise _! use z a prev5tive measure1 to immunize ! work]s 9 ! indu/ries8 ,m4,d41 ,canton1 ,ohio4 ,,answ]4--,! /atus ( vacc9e !rapy z a prophylactic = influ5za may be asc]ta9$ f ! two articles appe>+ 9 ,! ,j\rnal1 ,aug4 #i1 #aiai3 t ( ,e4 ,c4 ,ros5[ & ,b4 ,f4 ,/urdivant entitl$ 8,/udies 9 ,influ5za & ,pneumonia3 ,fur!r ,results ( ,prophylactic ,inoculations10 & t ( ,g4 ,w4 ,mc,coy1 director1 ,hygi5ic ,laboratory1 ,u4 ,s4 ,public ,heal? ,s]vice1 on 8,/atus ( ,prophylactic ,vacc9ation ,aga9/ ,influ5za40 ,9 brief1 ! conclusion ( ,ros5[ & ,/urdivant is3 8,x appe>s f all ( ! facts at h& t by ! use ( a prop]ly prep>$ vacc9e x is possible to rob influ5za ( "s ( its t]rors40 ,on ! o!r h&1 ,mc,coy /ates3 8,! g5]al impression ga9$ f uncontroll$ use ( vacc9es is t !y are ( value 9 ! prev5tion ( influ5za2 b1 9 e case 9 :i* vacc9es h be5 tri$ "u p]fectly controll$ conditions1 !y h fail$ to influ5ce 9 a def9ite mann] ei!r ! morbidity or ! mortality40 ,to make a cons]vative /atem5t3 ,! use ( vacc9e z a prophylactic 9 influ5za is an exp]im5t4--7,qu]y 9 ,! ,j\rnal ,a4 ,m4 ,a41 ,sept4 #bg1 #aiai47 ,vacc9es = 8,colds0 ,to ! ,editor3--,has !re be5 "w done ( suffici5t ext5t to be ( value 9 ju/ify+ use ( mix$ 8%otgun0 vacc9es to abort or immunize 8common colds10 t is1 rh9itis1 ph>yngitis1 acute bron*itis1 coryza1 etc48 ,*>les ,e4 ,b5nett1 ,m4,d41 ,aneta1 ,n4 ,d4 ,,answ]4--,we "k ( no inve/igation :i* demon/rates t ! use ( ! comm]cial mix$ vacc9es are ( value 9 ! prev5tion or treatm5t ( 8common colds0 or ( simil> affections4 ,! ,c\ncil on ,ph>macy & ,*emi/ry accepts = ,new & ,non(ficial ,rem$ies mix$ vacc9es only on condition t _! usefulness has be5 e/abli%$ by acceptable cl9ical evid5ce2 s f> x has n admitt$ any ( ! 8influ5za0 or 8cat>rhal0 mix$ vacc9es4--7,correspond5ce 9 ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #aj1 #aiag47 ,to ! ,editor3--,please advise me ( ! late/ & be/ vacc9e = common colds4 ,l4 ,j4 ,smi?1 ,m4,d41 ,wilson1 ,n4 ,c4 ,heal? ,(fic]1 ,city & ,c\nty ,heal? ,dep>tm5t4 ,,answ]4--,!re is no sci5tific evid5ce t common colds c be prev5t$ by ! use ( vacc9es1 despite ! gl[+ recomm5dations ( vacc9e mak]s & ! patt] ( ! detail man4 ,colds *>act]iz$ by cat>rhal inflammation ( ! muc\s membranes ( ! nose & ?roat are caus$ by v>i\s organisms1 includ+ a numb] ( ! common] cocci & ! bacillus ( ,pfeiff]4 ,!y are contagi\s1 & spread rapidly f "o p]son to ano!r by ! transf] ( ! bact]ia conc]n$1 s t small epidemics ( colds are cont9ually occurr+ 9 homes & communities4 ,! organism conc]n$ 9 "o small epidemic may be diff]5t f t 9 ano!r1 & x is impossible to anticipate :at organism is ab\t to invade ! h\sehold or community4 ,! inoculation ( mix$ vacc9es 9 ! hope ( provid+ aga9/ a numb] ( possible invad]s fails to produce immunity suffici5t to prev5t ! infection ( muc\s membranes4 ,:]e completely controll$ exp]im5ts h be5 made ) l>ge numb]s ( p]sons1 colds h occurr$ among ! inoculat$ 9 z l>ge proportion z among ! un9oculat$4 ,dur+ ! w>1 "s evid5ce 0 obta9$ :i* indicat$ t prev5tive inoculation ( troops ) a vacc9e conta9+ l>ge numb]s ( pneumococci r$uc$ ! incid5ce & mortality ( pneumonia4 ,9 ! case ( sup]ficial infection ( ! nasal & ph>yngeal muc\s membranes ) div]se etiology1 less c be expect$1 & practical results indicate t ?is skepticism bas$ on !oretical consid]ations is well f\nd$4--7,qu]y 9 ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #ac1 #aibj47 ,,index ,,& ,,bibliography ,see ,clos+ ,p>agraph to ,preface1 ,page ,,iv4 ,,page ,abbott ,laboratories-- ,b4 ,coli-,comb9$-,bact]91 #ahe ,b>bital1 #cga ,calcid9 ,tablets1 #dfe ,m4 ,cat>rhalis-,comb9$-,bact]91 #ahd ,neuro-,leci?91 #ec ,p]tussis-,comb9$-,bact]91 #ahe ,proca9-,abbott1 #cef ,/reptococcus-,rheumaticus-,comb9$-,bact ]91 #ahe1 #ahf ,/reptococcus-,viridans-,comb9$-,bact]91 #ahe1 #ahf ,triple ,ars5ates ) ,nucle91 #bef ,abrams1 ,alb]t1 #dgb ,abrams1 ,alb]t1 def5se (1 by ,upton ,s9clair1 #dgg ,acetanilid & ,sodium ,bromid ,tablets1 #eff ,acetanilid ,comp\nd1 ,mul=d1 #bjf ,acet-,ph5etid9 ,comp\nd1 ,p4-,m4 ,co41 ,tablets 7,pitman-,moore ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiah1 p4 #gc4 ,acetylsalicylic ,acid3 ,see also ,aspir94 ,acetylsalicylic ,acid1 ,am]ican-made1 exam9ation (1 #cdd ,acetylsalicylic ,acid 7,aspir97 ,monsanto1 #cdg ,acetylsalicylic ,acid1 ,m4 ,c4 ,w1 #cdg ,acetylsalicylic ,acid1 ,millik91 #cdg ,acetylsalicylic ,acid1 n ,aspir91 #dhj ,acetylsalicylic ,acid1 ,p4 ,w4 ,r1 #cdg ,acetylsalicylic ,acid1 ,squibb1 #cdg ,acetylsalicylic ,acid--8,:at's 9 a ,"n401 #dhb ,adr5o-,sp]m9 ,comp41 ,caps1 #bai ,adv]tis+ by means ( 8orig9al0 articles 9 m$ical j\rnals1 #efj ,adv]tis+ pr9ciples--lay & m$ical1 #dhc ,ag>-lac 7,e4 ,f\g]a ,co41 ,inc471 ,! ,j\rnal1 ,nov4 #ad1 #aiad1 p4 #aggg2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiad1 p4 #abd2 ,propag&a1 ed4 #i1 p4 #aj4 ,agmel 7,maguey ,products ,co471 ,! ,j\rnal1 ,oct4 #ab1 #aiab1 p4 #acib4 ,akoz1 lead 91 #cbh ,akoz ,m$ic9al ,m9]al ,wat]1 #cbh ,akoz ,o9tm5t1 #cbh ,akoz ,p[d]1 #cbh ,akoz ,suppositories1 #cbh ,albol5e1 ,liquid1 #ajf ,albol5e1 ,liquid 7,mc,kesson ,robb9s71 ,! ,j\rnal1 ,july #bf1 #aiac1 p4 #bif2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiaf1 p4 #fe4 ,alborum 7,! ,:iteh\se ,*emical ,co41 ,inc471 ,! ,j\rnal1 ,dec4 #ab1 #aiad1 p4 #badh2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiad1 p4 #abi4 ,alcohol1 ,hygi5e & ,legislation1 #die ,alcre/a ,d5tal ,lotion-,lilly 7,eli ,lilly ,co471 ,! ,j\rnal1 ,oct4 #bi1 #aiba1 p4 #adda4 ,alcre/a ,ipecac1 #aec ,alcre/a ,ipecac 7,eli ,lilly ,co471 ,! ,j\rnal1 ,oct4 #bj1 #aiag1 p4 #acgc2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiag1 p4 #fb4 ,alcre/a ,lotion1 #dfe ,aletr91 ,! ,j\rnal1 ,nov4 #ac1 #aiji1 p4 #afee2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiji1 p4 #ace4 ,aletris ,comp\nd1 ,elixir 7,p>ke1 ,davis ,co42 ,ray ,*emical ,co472 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #df4 ,aletris ,cordial 7,rio ,*emical ,co471 ,! ,j\rnal1 ,oct4 #ag1 #aiad1 p4 #adaa2 ,feb4 #ac1 #aiae1 p4 #fjf2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiad1 p4 #ii2 ,propag&a1 ed4 #i1 p4 #dc4 ,alex&]1 ,h4 ,m41 ,company-- ,dixon's ,tub]cle ,bacilli ,extract & ,dixon's ,susp5sion ( ,dead ,tub]cle ,bacilli1 #aeh ,alfatone1 #bh ,alfatone 7,norwi* ,ph>macal ,company71 ,! ,j\rnal1 ,aug4 #g1 #aiae1 p4 #edh2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #fb4 ,alkal9e ,dige/9e 7,p>ke1 ,davis ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #dd4 ,alkali?ia1 #bdb ,alkali?ia 7,keasbey & ,mattison ,company71 ,reports ,c\ncil ,ph>m4 ,*em41 #aiai1 p4 #fe4 ,alkalol 7,alkalol ,co471 ,! ,j\rnal1 ,nov4 #f1 #aiae1 p4 #affe2 ,reports ,*em4 ,lab41 #aiae1 p4 #aaj4 ,alleotone 7,b4 ,f4 ,copel&71 ,! ,j\rnal1 ,feb4 #a1 #aijh1 p4 #cgi2 ,propag&a1 ed4 #i1 p4 #bfd4 ,alli$ ,m$ical ,associations ( ,am]ica1 #dhf ,alphozone1 #ii ,alphozone 7,fr$]ick ,/e>ns ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiaf1 p4 #ej4 ,ambr9e1 analysis (1 #ccb 8,ambr9e0 & ,p>aff9 ,films1 #ccj ,ambr9e1 ,! ,j\rnal1 ,april #g1 #aiag1 p4 #ajeg2 ,may #ai1 #aiag1 p4 #adig2 ,reports ,*em4 ,lab41 #aiag1 p4 #bj4 ,am]ican ,animal ,!rapy ,co1 #ebh ,am]ican ,elixir ( ,bitt] ,w9e1 ,tr9]'s1 #aci ,am]ican-made syn!tic drugs1 #cdd1 #cfi ,am]ican ,m$ical ,association ,*emical ,laboratory1 =eword1 #cbb ,am]ican ,m$ical ,association ,*emical ,laboratory1 "w (1 #cbb ,am]ican ,m$ical ,association ,c\ncil on ,ph>macy & ,*emi/ry1 delays 9 pass+ on products1 #bj ,am]ican ,m$ical ,association ,c\ncil on ,ph>macy & ,*emi/ry1 =eword1 #a ,am]ican ,m$ical ,association ,c\ncil on ,ph>macy & ,*emi/ry (f]s s]vices simil> to ,dun & ,brad/reet1 #egj ,am]ican ,m$ical ,association ,c\ncil on ,ph>macy & ,*emi/ry1 (ficial rules (1 #c ,am]ican ,m$ical ,association ,c\ncil on ,ph>macy & ,*emi/ry1 pres5t & future1 #ab ,am]ican ,m$ical ,association ,c\ncil on ,ph>macy & ,*emi/ry endors$ by ,! ,j\rnal ( ! ,miss\ri ,/ate ,m$ical ,association1 #ai ,am]ican ,organo!rapy ,company1 #ebg ,ammonium ,*loride1 ,tro*es (1 druggi/s refuse to supply1 #eeb ,ammonium ,hypophosphite1 #ih ,ammonium ,hypophosphite1 ,g>dn]'s ,syrup (1 #ajj ,ammonium ,hypophosphite1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiaf1 p4 #ea4 ,ammonol1 #cic ,ammonol 7,ammonol ,*emical ,co471 ,! ,j\rnal1 ,june #c1 #aije1 p4 #agia2 ,feb4 #b1 #aiah1 p4 #ccg2 ,reports ,c\ncil ,ph>m4 ,*em41 #aije1 #aijh1 p4 #g2 ,propag&a1 ed4 #i1 p4 #i4 ,amol9 ,deodorant ,p[d] 7,amol9 ,*emical ,co471 ,! ,j\rnal1 ,feb4 #bb1 #aijh1 p4 #fbf2 ,reports ,*em4 ,lab41 #aiji1 p4 #fc4 ,anadol 7,:eel] ,*emical ,works71 ,! ,j\rnal1 ,may #ba1 #aiaj1 p4 #agjd2 ,propag&a1 ed4 #i1 p4 #bde4 ,analutos & ,analutos ,tablets 7,royal ,ph>maceutical ,works1 ,meppel1 ,holl&71 ,! ,j\rnal1 ,feb4 #bj1 #aiae1 p4 #fhd2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #ace2 ,reports ,*em4 ,lab41 #aiae1 p4 #aca4 ,anas>c91 #chc ,anas>c9 adv]tis+1 #djg ,anas>c9 7,anas>c9 ,*emical ,co471 ,! ,j\rnal1 ,may #d1 #aijg1 p4 #aece2 ,dec4 #h1 #aiag1 p4 #aiib2 ,reports ,c\ncil ,ph>m4 ,*em41 #aije-h1 p4 #ed2 ,propag&a1 ed4 #i1 p4 #aa4 ,&]son ,sy/em = ,treatm5t ( ,alcoholism 7,! ,&]son ,laboratories71 ,reports ,c\ncil ,ph>m4 ,*em41 #aiaf1 p4 #ea4 ,an$em91 #chc ,an$em9 7,an$em9 ,*emical ,co471 ,! ,j\rnal1 ,may #d1 #aijg1 p4 #aece2 ,dec4 #h1 #aiag1 p4 #aiib2 ,reports ,c\ncil ,ph>m4 ,*em41 #aije-h1 p4 #ed2 ,propag&a1 ed4 #i1 p4 #aa4 ,ane/hes91 #bgf ,angi]'s ,emulsion 7,angi] ,*emical ,co471 ,! ,j\rnal1 ,sept4 #ab1 #aiad1 p4 #ifb2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiad1 p4 #dh2 ,reports ,*em4 ,lab41 #aiad1 p4 #ee2 ,propag&a1 ed4 #i1 p4 #afi4 ,anglo-,fr5* ,drug ,co41 ,ltd4-- ,collosol ,coca9e1 #bba ,collosol prep>ations1 #bbc ,cuprase1 #bbb ,sukro-,s]um1 #bgc ,supsalvs1 #bgd ,ani/am9a 7,m4 ,olivetti71 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #afb4 ,ant]o-,pituit>y ,comp41 ,caps1 #bai ,antidiabeticum1 ,bau] 7,san9-,gesells*aft71 ,! ,j\rnal1 ,july #cj1 #aiaj1 p4 #dah2 ,propag&a1 ed4 #i1 p4 #bfg4 ,antidys5t]ic ,s]um 7,f>bw]ke-,hoe*/ ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiag1 p4 #adf4 ,antikamnia 7,antikamnia ,*emical ,co471 ,! ,j\rnal1 ,june #c1 #aije1 p4 #agia2 ,feb4 #h1 #aijh1 p4 #dfg2 ,reports ,c\ncil ,ph>m4 ,*em41 #aije-h1 p4 #g2 ,reports ,*em4 ,lab41 to #aiji1 p4 #fj2 ,propag&a1 ed4 #i1 pp4 #i1 #bfh1 #cjg4 ,antikamnia & ,qu99 7,antikamnia ,*emical ,co471 ,! ,j\rnal1 ,july #a1 #aije1 p4 #ee4 ,anti-,malta ,fev] ,s]um 7,h4 ,k4 ,mul=d ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiag1 p4 #acf4 ,antim]i/em-,s*midt1 #djh ,antim]i/em-,s*midt 7,laboratorium ,w4 ,s*midt71 ,! ,j\rnal1 ,m>* #h1 #aiac1 p4 #gff2 ,dec4 #f1 #aiai1 p4 #aghg4 ,antiphlogi/9e1 #dji ,antiphlogi/9e 7,d5v] ,*emical ,mfg4 ,co471 ,! ,j\rnal1 ,june #a1 #aijg1 p4 #ahge2 ,feb4 #bc1 #aiah1 p4 #eeg4 ,anti-,pneumococcic ,oil 7,eim] & ,am5d71 ,! ,j\rnal1 ,jan4 #c1 #aibj1 p4 #df2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiai1 p4 #eb4 8,anti-,pneumococcic ,oil0 & ! use ( camphor 9 pneumonia1 #beg ,antipneumococcus ,s]um 7,f>bw]ke-,hoe*/ ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiag1 p4 #adf4 ,antiseptic ,p[d]1 ,maign5 7,maign5 ,in/itute71 ,! ,j\rnal1 ,nov4 #ad1 #aiad1 p4 #aggh2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiad1 p4 #eg2 ,propag&a1 ed4 #i1 p4 #ai4 ,antiseptic ,p[d]1 ,tyree's1 #dfb ,antiseptic ,p[d]1 ,tyree's 7,j4 ,s4 ,tyree71 ,! ,j\rnal1 ,oct4 #bj1 #aijf1 p4 #acaf2 ,aug4 #bd1 #aiab1 p4 #fff2 ,m>* #cj1 #aiah1 p4 #idi2 ,reports ,c\ncil ,ph>m4 ,*em41 #aije-h1 p4 #bb2 ,propag&a1 ed4 #i1 pp4 #ba1 #djd2 ,may #ag1 #aiai1 p4 #adhb4 ,antiseptic ,tablets ,clov] 7,%>p ,dohme71 ,! ,j\rnal1 ,aug4 #bf1 #aiaa1 p4 #gee4 ,antiseptic1 ,tyree's1 #dja ,anti/aphylococcus ,s]um 7,burr\ghs ,wellcome ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiag1 p4 #acg4 ,anti/reptococcus ,s]um1 ,aronson's 7,s*]+ ,glatz1 ,inc471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiag1 p4 #adf4 ,anti/reptococcus ,s]um 8,hoe*/0 7,f>bw]ke-,hoe*/ ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiag1 p4 #adf4 ,anti-,syphilitic ,comp\nd 7,swe5y71 #bfh1 #ccj ,anti-,syphilitic ,comp\nd ,swe5y 7,national ,laboratories ( ,pittsburgh71 ,! ,j\rnal1 ,april #c1 #aibj1 p4 #ife2 ,reports ,c\ncil ,ph>m4 ,*em41 #aibj1 p4 #ab4 ,anti!rmol9e 7,g4 ,w4 ,c>nrick ,co471 ,! ,j\rnal1 ,nov4 #a1 #aiac1 p4 #afdi4 ,anti?yroid ,prep>ations 7,anti?yroid9-,moebius & ,?yreoidect971 #bjb ,anti?yroid ,prep>ations1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiah1 p4 #ej4 ,anti?yroid9-,moebius 7,m]ck ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiah1 p4 #ej4 ,anti?yroid9-,moebius & ,?yreoidect91 ,anti?yroid ,prep>ations1 #bjb ,anti-,tub]cul\s ,lymph ,comp\nd 7,swe5y71 #bff ,anti-,tub]cul\s ,lymph ,comp\nd1 ,swe5y 7,national ,laboratories ( ,pittsburgh71 ,! ,j\rnal1 ,april #c1 #aibj1 p4 #ife2 ,reports ,c\ncil ,ph>m4 ,*em41 #aibj1 p4 #ab4 ,anti-,vomit ,tablets1 #eff ,anusol ,suppositories1 #ahb ,anusol ,suppositories 7,s*]+ ,glatz1 ,inc471 ,! ,j\rnal1 ,oct4 #b1 #aiji1 p4 #aaab2 ,oct4 #aa1 #aiac1 p4 #acib2 ,jan4 #ca1 #aiad1 p4 #cie2 ,m>* #i1 #aiah1 p4 #gai2 ,reports ,*em4 ,lab41 #aiji1 p4 #cb2 ,propag&a1 ed4 #i1 pp4 #bbg1 #bhj1 #bha4 ,ap]gols 7,h4 ,k4 ,wampole ,co41 ,inc471 ,! ,j\rnal1 ,dec4 #ab1 #aiad1 p4 #badi2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiad1 p4 #fd2 ,propag&a1 ed4 #i1 p4 #bf4 ,aphlegmatol1 #bgc ,aphlegmatol 7,g4 ,giambalvo ,co471 ,! ,j\rnal1 ,aug4 #ba1 #aibj1 p4 #eef2 ,reports ,c\ncil ,ph>m4 ,*em41 #aibj1 p4 #bc4 ,apo!s9e1 #bfj ,aquazone 7,oxyg5 ,wat]71 #bij ,aquazone 7,oxyg5 ,wat]7 7,aquazone ,laboratories1 ,inc471 ,reports ,c\ncil ,ph>m4 ,*em41 #aibj1 p4 #ej4 ,arbor ,vitae1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #ch4 ,arhov91 #bdc ,arhov9 7,s*]+ ,glatz1 ,inc471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiai1 p4 #ff4 ,arm]v5ol1 #bdi ,arm]v5ol 7,hille ,laboratories71 ,reports ,c\ncil ,ph>m4 ,*em41 #aiai1 p4 #hb4 ,arm\r & ,company-- ,duod591 #gf ,leci?ol1 #ec ,p9eal ,gl& ,prep>ations1 #bac ,r$ ,bone-,m>r[ ,prep>ations1 #bac ,?ymus ,gl& ,prep>ations1 #bad 8,arrh5al01 #dib ,arrh5al 7,e4 ,f\g]a ,co47 ,! ,j\rnal1 ,feb4 #bf1 #aiba1 p4 #eie4 ,ars5ates1 ,triple1 ) ,nucle91 #bef ,ars5ic & ,m]cury1 ,solution (1 #bca ,ars5ic & ,m]cury1 ,solution ( 7,new ,york ,intrav5\s ,laboratory71 ,! ,j\rnal1 ,aug4 #b1 #aiai1 p4 #cec2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiai1 p4 #bf4 ,ars5ic1 ,iron & ,phosphorus ,comp\nd1 ,hypod]mic ,solution ,no4 #ac1 #bge 8,ars5icals01 #dia ,ars5icals1 ph>macology (1 #dib ,ars5o-,me?4 ,hyd43 ,see ,ars5ic & ,m]cury1 ,solution (4 8,ars5ov51 ,s4 ,s401 #bca ,ars5ov51 ,s4 ,s4 7,s4 ,s4 ,products ,co471 ,! ,j\rnal1 ,aug4 #b1 #aiai1 p4 #cec2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiai1 p4 #bf4 ,arsph5am91 #dia1 #did ,aseptikons 7,*9osol ,co471 ,! ,j\rnal1 ,nov4 #ad1 #aiad1 p4 #aggh2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiad1 p4 #abd2 ,propag&a1 ed4 #i1 p4 #bf4 ,asept9ol1 #dja ,asept9ol 7,asept9ol ,mfg4 ,co471 ,! ,j\rnal1 ,m>* #cj1 #aiah1 p4 #idi4 ,aspir93 ,see also ,acetylsalicylic ,acid4 ,aspir91 #aaf1 #edd ,aspir9 7,! ,bay] ,co41 ,inc471 ,! ,j\rnal1 ,jan4 #bj1 #aiag2 ,april #ac1 #aiah1 p4 #ajig2 ,june #ab1 #aibj1 p4 #affd2 ,may #ad1 #aiba1 p4 #acef2 ,june #aa1 #aiba1 p4 #afig2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiaf1 p4 #dc4 ,aspir9--a common "n1 #dhd ,aspir91 ,acetylsalicylic ,acid n ,aspir91 #dhj ,aspir9 adv]tisem5ts1 #dhc ,aspir9 ,bay]1 #aaf1 #cdg1 #dhj 8,aspir9 ,bay]0 & ! ,/]l+ ,products ,company1 #dhe ,aspir91 ,lehn & ,f9k1 #cdg ,aspir9 ,tablets1 #eff ,aspiro-,li?9e 7,mc,kesson ,robb9s71 ,! ,j\rnal1 ,may #bh1 #aiaj1 p4 #ahjc2 ,propag&a1 ed4 #i1 p4 #bha4 ,atlanta ,j\rnal-,record ( ,m$ic9e & ,gray's ,glyc]9e ,tonic1 #dbi ,atophan1 #cac1 #cgc1 #dai ,atophan 7,ph5ylc9*on9ic 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#aiae1 p4 #ace4 ,cod-,liv] ,oil ,comp\nd1 ,hagee's ,cordial ( ! ,extract ( 7,ka?>mon ,*emical ,co471 ,! ,j\rnal1 ,oct4 #ac1 #aijf1 p4 #abjh2 ,april #aj1 #aiae1 p4 #abfb2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #ach2 ,propag&a1 ed4 #i1 pp4 #ea1 #bhi4 ,cod-,liv] ,oil ,comp\nd1 ,wat]bury's ,metaboliz$ 7,wat]bury ,*emical ,co471 ,! ,j\rnal1 ,oct4 #i1 #aiji1 p4 #abja2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiji1 p4 #aae2 ,propag&a1 ed4 #i1 p4 #bia4 ,see also ,comp\nd1 ,wat]bury's4 ,cod-,liv] ,oil1 ,hagee's ,cordial (1 #dbi ,cod-,liv] ,oil ) ,maltzyme1 #baa ,coho%1 ,blue1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #dj4 ,colal91 #bjc ,colal9 7,s*ieffel9 ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiah1 p4 #eb4 ,col*i-,me?yl ,capsules 7,h4 ,k4 ,wampole ,co41 ,inc471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #afi4 ,col*i-,sal 7,e4 ,f\g]a ,co41 ,inc471 ,! ,j\rnal1 ,m>* #bj1 #aiae1 p4 #ajaf2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #acf2 ,propag&a1 ed4 #i1 p4 #eh4 8,colds10 ,vacc9es =1 #egc ,colloid ,solution 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,collosol ,manganese1 ,collosol ,qu991 & ,collosol ,sulphur7 7,anglo- ,fr5* ,drug ,co41 ,ltd471 ,! ,j\rnal1 ,june #g1 #aiai1 p4 #afid2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiai1 p4 #ad4 ,collosol ,qu991 #bbc1 #bbf 8,collosols30 an uncritical ,engli% endorsem5t1 #dbj ,collosol ,sulphur1 #bbc1 #bbf ,collyrium1 ,wye? 7,john ,wye? ,bro471 ,! ,j\rnal1 ,may #ag1 #aiac1 p4 #aeeg2 ,propag&a1 ed4 #i1 p4 #bib4 ,comp\nd ,elixir ( ,phosphates & ,calisaya3 ,see ,tissue ,phosphates1 ,:eel]'s4 ,comp\nd1 ,wat]bury's 7,wat]bury ,*emical ,co471 ,! ,j\rnal1 ,m>* #bj1 #aiae1 p4 #ajaf2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #ach2 ,propag&a1 ed4 #i1 p4 #eg4 ,conc5trat$ ,solution ,sodium ,hypo*lorite-,mul=d1 #ceh ,condurango1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiaa1 p4 #ed4 ,coop]ation ( ! ,ph>maceutical ,h\ses1 ,reports ,c\ncil ,ph>m4 ,*em41 #aibj1 p4 #ef4 ,copp] ,ph5olsulphonate 7,! ,abbott ,laboratories71 ,reports ,c\ncil ,ph>m4 ,*em41 #aiaf1 p4 #ed4 ,cordial ( ,cod ,liv] ,oil1 ,hagee's1 #dbi ,corpora ,lutea 7,soluble ,extract7 ,p>ke1 ,davis ,co1 #abh ,corpora ,lutea 7,soluble ,extract7 7,p>ke1 ,davis ,co471 ,! ,j\rnal1 ,april #g1 #aiag1 p4 #ajef2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiag1 p4 #bj4 ,corydalis ,comp\nd1 ,elixir 7,p>ke1 ,davis ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #dg4 8,cosmopolitan ,canc] ,rese>* ,society0 & ,basic ,canc] ,rese>*1 #dad ,cot>n9 ,salts 7,/yptic9 & ,/yptol71 #bdj ,cot>n9 ,salts1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiai1 p4 #ci4 ,coto1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiac1 p4 #ci4 ,coto91 ,reports ,c\ncil ,ph>m4 ,*em41 #aiac1 p4 #ci4 ,cotton ,process ,e!r1 #dba ,c\ncil on ,ph>macy & ,*emi/ry3 ,see ,am]ican ,m$ical ,association4 ,cream ( ,mu/>d1 #bah ,cream ( ,mu/>d 7,! ,cream ( ,mu/>d ,co41 ,s\? ,norwalk1 ,conn471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiah1 p4 #gi4 ,cream ( ,sulphur1 ,o',grady's ,m$icat$ ,m9]al 7,john ,h4 ,o',grady1 ,m9neapolis71 ,reports ,c\ncil ,ph>m4 ,*em41 #aiah1 p4 #ha4 ,creo ,f]rum 7,! ,gross ,drug ,co41 ,inc471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiba1 p4 #af4 ,cre(os1 #acg ,cre(os 7,delson ,*emical ,co471 ,! ,j\rnal1 ,july #g1 #aiag1 p4 #eh2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiag1 p4 #cd4 ,creosote-,delson1 #acg ,creosote-,delson 7,delson ,*emical ,co471 ,! ,j\rnal1 ,july #g1 #aiag1 p4 #eh2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiag1 p4 #cd4 ,creosotonic 7,scott71 #aib1 #aic ,creosotonic 7,scott7 7,dawson ,ph>macal ,co471 ,! ,j\rnal1 ,aug4 #bd1 #aiah1 p4 #fhj2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiah1 p4 #be4 ,critt5ton ,company1 ,*>les ,n4--,hydrole9e1 #eh ,crookes ,laboratories--,collosols1 #dbj ,cr\/ils1 ,simple ,no4 #a 7,oat5 ,bread7 7,la,porte ,gau?i]71 ,reports ,c\ncil ,ph>m4 ,*em41 #aiba1 p4 #ag4 ,cr\/ils1 ,no4 #b 7,de*loridis$ & ,lactos$7 7,la,porte ,gau?i]71 ,reports ,c\ncil ,ph>m4 ,*em41 #aiba1 p4 #ag4 ,cr\/ils1 ,no4 #c 7,glut9iz$7 7,la,porte ,gau?i]71 ,reports ,c\ncil ,ph>m4 ,*em41 #aiba1 p4 #ag4 ,cu-,co-,ba ,t>rant 7,! ,t>rant ,co471 ,! ,j\rnal1 ,sept4 #be1 #aibj1 p4 #hia4 ,cuprase1 #bbb ,cuprase 7,anglo-,fr5* ,drug ,co41 ,ltd471 ,! ,j\rnal1 ,april #ab1 #aiai1 p4 #ajie2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiai1 p4 #aj4 ,cur>e1 ,! ,j\rnal1 ,jan4 #ae1 #aiaj1 p4 #bai2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiaj1 p4 #g4 ,cur>91 ,! ,j\rnal1 ,jan4 #ae1 #aiaj1 p4 #bai2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiaj1 p4 #g4 ,curative ,vacc9e1 ,brus*ett9i1 #eh ,curative ,vacc9e1 ,brus*ett9i 7,a4 ,brus*ett9i71 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #agf4 ,cypridol ,capsules 7,e4 ,f\g]a ,co41 ,inc471 ,! ,j\rnal1 ,dec4 #ai1 #aiad1 p4 #bbdg2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiad1 p4 #gg2 ,propag&a1 ed4 #i1 p4 #ei4 ,cy/og5 7,cy/og5 ,*emical ,co471 ,! ,j\rnal1 ,dec4 #ab1 #aiad1 p4 #badh2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiad1 p4 #ff2 ,propag&a1 ed4 #i1 p4 #fj4 ,cy/og5 ,ap]i5t 7,cy/og5 ,*emical ,co471 ,! ,j\rnal1 ,dec4 #ab1 #aiad1 p4 #badh2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiad1 p4 #ff2 ,propag&a1 ed4 #i1 p4 #fj4 ,cy/og5 ,li?ia 7,cy/og5 ,*emical ,co471 ,! ,j\rnal1 ,dec4 #ab1 #aiad1 p4 #badh2 ,reports ,ph>m4 ,*em41 #aiad1 p4 #ff2 ,propag&a1 ed4 #i1 p4 #fj4 ,cy/o-,s$ative 7,/rong1 ,cobb ,co471 ,! ,j\rnal1 ,dec4 #ab1 #aiad1 p4 #badh2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiad1 p4 #acj2 ,propag&a1 ed4 #i1 p4 #fa4 ,daggett & ,mill] ,company1 ,inc4--,hex-,iod91 #bcf ,damiana1 ,all5's ,comp\nd ,extract ( 7,all5-,pfeiff] ,*emical ,co471 ,! ,j\rnal1 ,july #ai1 #aiac1 p4 #baa4 ,d>p9 7,rio ,*emical ,co471 ,! ,j\rnal1 ,feb4 #ac1 #aiae1 p4 #fjf2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiad1 p4 #ii2 ,propag&a1 ed4 #i1 p4 #dc4 ,dawson ,ph>macal ,company--,iodoniz$ ,emulsion 7,scott7 & ,creosotonic 7,scott71 #aib ,delson ,*emical ,co41 ,inc4--,creosote-,delson & ,cre(os1 #acg ,d5v] ,*emical ,mfg4 ,co4--,antiphlogi/9e1 #dji ,de ,sanctis' ,rheumatic & ,g\t ,pills1 #cfc ,desiccat$ ,p9eal ,gl&--,arm\r1 #bac ,desiccat$ ,?ymus--,arm\r1 #bac ,diabetic ,biscuit 7,jireh ,diabetic ,food ,co471 ,! ,j\rnal1 ,m>* #bb1 #aiac1 p4 #ibb4 ,diabetic ,fl\r1 ,jireh 7,jireh ,diabetic ,food ,co471 ,! ,j\rnal1 ,m>* #bb1 #aiac1 p4 #ibb4 ,diabetic ,food1 ,jireh 7,jireh ,diabetic ,food ,co471 ,! ,j\rnal1 ,dec4 #ad1 #aiab1 p4 #bagd4 ,dial 8,ciba01 #bei ,dianol ,i1 ,dianol ,,ii1 & ,dianol ,,iii 7,kalle ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiac1 p4 #cd2 ,reports ,*em4 ,lab41 #aiac1 p4 #ge4 ,di>rhea ,calomel ,pills1 #eff ,dia/os1 ,liquor 7,h4 ,k4 ,mul=d ,co471 ,! ,j\rnal1 ,feb4 #i1 #aijg1 p4 #ecc4 ,diatuss9 7,e4 ,bis*(f ,co471 ,! ,j\rnal1 ,may #ag1 #aiac1 p4 #aeeg2 ,propag&a1 ed4 #i1 p4 #bic4 ,di-,crotal9 7,swan-,my]s ,co471 ,! ,j\rnal1 ,aug4 #ag1 #aiah1 p4 #eib4 ,di-,crotal9 treatm5t ( epilepsy1 #dfe ,die?ylb>bituric ,acid 7,m]ck71 #cga ,digal5 7,h(fmann-,la,roche ,*emical ,works71 ,! ,j\rnal1 ,sept4 #e1 #aiad1 p4 #hha2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiad1 p4 #cc2 ,propag&a1 ed4 #i1 p4 #fh4 ,dige/ive ,tablets1 ,aromatic 7,fras] ,tablet ,co42 ,wm4 ,s4 ,m]rill ,*emical ,co42 ,h4 ,k4 ,mul=d ,co42 ,p>ke1 ,davis ,co42 ,%>p ,dohme71 ,! ,j\rnal1 ,aug4 #bj1 #aiaj1 p4 #gaj2 ,reports ,*em4 ,lab41 #aiaj1 p4 #fg2 ,propag&a1 ed4 #i1 p4 #bcb4 ,dige/ive ,tonic 7,truax1 ,gre5e ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #dd4 ,digifol9-,ciba1 #bih ,digifol9-,ciba 7,ciba ,company1 ,inc471 ,! ,j\rnal1 ,april #b1 #aiba1 p4 #ieb2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiba1 p4 #bj4 ,digitalis ,tablets1 ,we/]field's1 #bae ,digitalis ,tablets1 ,we/]field's 7,we/]field ,ph>macal ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiah1 p4 #ge4 ,digitalone 7,p>ke1 ,davis ,co471 ,! ,j\rnal1 ,june #ab1 #aiji1 p4 #aich2 ,dec4 #g1 #aiab1 p4 #bjgd2 ,jan4 #aa1 #aiac1 p4 #adc4 ,digitalysatum1 #fc ,digitalysatum 7,e4 ,bis*(f ,co471 ,! ,j\rnal1 ,feb4 #ae1 #aiac1 p4 #dii2 ,jan4 #h1 #aiaf1 p4 #ace2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #ic4 ,dionol1 #dbb ,dionol 7,dionol ,company71 ,! ,j\rnal1 ,jan4 #bf1 #aiah1 p4 #beg2 ,feb4 #g1 #aibj1 p4 #daj4 ,diorad9 7,diorad9 ,co471 ,! ,j\rnal1 ,oct4 #bf1 #aiab1 p4 #aeef2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #bc2 #aiac1 p4 #cg2 ,propag&a1 ed4 #i1 p4 #gc4 ,dios ,*emical ,company--,neuros9e1 #djd ,dioscorea ,comp\nd1 ,elixir 7,h4 ,k4 ,mul=d ,co42 ,p>ke1 ,davis ,co42 ,ray ,*emical ,co42 ,f4 ,/e>ns ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #df4 ,dioviburnia 7,dios ,*emical ,co471 ,! ,j\rnal1 ,aug4 #ca1 #aiab1 p4 #gce2 ,jan4 #i1 #aiae1 p4 #aff2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #df2 #aiad1 p4 #hf2 ,propag&a1 ed4 #i1 pp4 #aci1 #daj4 ,diph!ria ,antitox9 7,f>bw]ke-,hoe*/ ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiag1 p4 #adf4 ,diph!ria ,antitox91 ,conc5trat$ 7,national ,vacc9e & ,antitox9 ,in/itute71 ,reports ,c\ncil ,ph>m4 ,*em41 #aiba1 p4 #bc4 ,diph!ria ,bacillus ,vacc9e1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiah1 p4 #ed4 ,direct ,ph>maceutical ,co4 & ,william ,a4 ,web/] ,co41 #efd ,direct ,sales ,company1 #eaj ,discov]ies & ,discov]]s1 #eaa ,diuret9 7,knoll ,co471 ,! ,j\rnal1 ,april #d1 #aiad1 p4 #aajh2 ,reports ,*em4 ,lab41 #aiad1 p4 #g2 ,propag&a1 ed4 #i1 p4 #bea4 ,diurol 7,h4 ,k4 ,mul=d ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #de4 ,dixon's ,susp5sion ( ,dead ,tub]cle ,bacilli1 #aeh ,dixon's ,susp5sion ( ,dead ,tub]cle ,bacilli1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiag1 p4 #adj4 ,dixon's ,tub]cle ,bacilli ,extract1 #aeh ,dixon's ,tub]cle ,bacilli ,extract2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiag1 p4 #adj4 ,dogwood1 ,fl[]+1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #da4 ,dosage1 dep5dability ( tablet dosage1 #eef ,dott]wei*1 ,g4 ,j41 & ,c4 ,k41 ,(fic]s ( ,direct ,sales ,company1 #eaj ,drug ,products ,co41 ,inc4-- ,pulvoids ,calcylates1 #he ,pulvoids ,calcylates ,comp\nd1 #bbf ,pulvoids ,natrium ,comp\nd1 #ajh 8,drug ,re=m0 z x appe>s to ! ,clevel& ,m$ical ,j\rnal1 #eac ,drug ,!rapy3 ! fallibility ( textbooks1 #eae ,drugs1 crucial te/ ( !rapeutic evid5ce1 #eeg ,dunn1 ,eli ,h41 ,eli products (1 #dbd ,duod591 #gf ,duod591 ,arm\r 7,arm\r ,co471 ,! ,j\rnal1 ,aug4 #ad1 #aiae1 p4 #fci2 ,jan4 #ae1 #aiaf1 pp4 #agh1 #bjh2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 pp4 #if1 #ii1 #aea2 #aiaf1 p4 #gb4 ,duotonol ,tablets1 #id ,duotonol ,tablets 7,s*]+ ,glatz1 ,inc471 ,! ,j\rnal1 ,sept4 #cj1 #aiaf1 p4 #ajcc2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiaf1 p4 #cd4 ,du ,pont ,de ,nem\rs1 ,e4 ,i4 & ,co41 ,inc4--,cotton ,process ,e!r1 #dba ,dys5t]y ,bact]9-,mul=d 7,h4 ,k4 ,mul=d ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiag1 p4 #ada4 ,dyspepsia ,comp\nd1 ,elixir 7,h4 ,k4 ,mul=d ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #dd4 ,dyspepsia1 ,elixir ,atonic1 ,ph5olat$ 7,wm4 ,s4 ,m]rell ,*emical ,co471 ,! ,j\rnal1 ,feb4 #i1 #aijg1 p4 #ecc4 ,e*9acea1 ,! ,j\rnal1 ,nov4 #bg1 #aiji1 p4 #ahcf2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiji1 p4 #add2 ,propag&a1 ed4 #i1 p4 #gi4 ,e*itone 7,/rong1 ,cobb ,co471 ,! ,j\rnal1 ,jan4 #b1 #aiae1 p4 #ga2 ,july #ag1 #aibj1 p4 #aic2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiad1 p4 #hj2 ,propag&a1 ed4 #i1 p4 #ha4 ,e*?ol 7,battle ,co471 ,! ,j\rnal1 ,m>* #ac1 #aiji1 p4 #ijd2 ,jan4 #b1 #aiae1 p4 #ga2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiji1 p4 #add2 #aiab1 p4 #ch2 #aiad1 p4 #hj2 ,propag&a1 p4 #ha4 ,e*tisia 7,wm4 ,s4 ,m]rell ,*emical ,co471 ,! ,j\rnal1 ,jan4 #b1 #aiae1 p4 #ga2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiad1 p4 #hj2 ,propag&a1 ed4 #i1 p4 #ha4 ,edema ,improv$1 ,tablet 7,p>ke1 ,davis ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #da4 ,edema ,tablet 7,p>ke1 ,davis ,co42 ,smi?1 ,kl9e ,fr5* ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #da4 ,edg>1 ,?omas ,web/]1 #eae ,edg>1 ,?omas ,web/]1 ,j\rnal receives a lett] d5\nc+ 8,m$ical ,cl]ks0 & 8,bias$ ,sceptres01 #eah ,edw>d ,p]cy ,rob9son's 8,cure0 = ,canc]1 #deh ,eim] & ,am5d-- 8,anti-,pneumococcic ,oil01 #beg ,phosphorc9 ,comp\nd1 #id ,el>son1 #bdh ,el>son 7,w9?rop ,*emical ,company1 ,inc471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiai1 p4 #ge4 ,eld]1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #da4 ,electrobioscope1 #dgb ,electr>gol 7,e4 ,f\g]a ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aibj1 p4 #eh4 ,electronic ,reactions1 #dgb ,eli products ( ,eli ,h4 ,dunn1 #dbd ,eli #fjf ,capsules1 #cbd1 #dbe ,eli ,vag9al ,capsules1 #dbd ,eli ,vim ,re/orative1 #dbd ,elixir ,glyc]ophosphates1 ,nux ,vomica & ,damiana1 #ie ,elixir ,glyc]ophosphates1 ,nux ,vomica & ,damiana 7,%>p ,dohme71 ,! ,j\rnal1 ,sept4 #cj1 #aiaf1 p4 #ajcd2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiaf1 p4 #ce4 ,elixir ,iodo-,bromide ( ,calcium ,comp4 8,)\t ,m]cury0 & 8,) ,m]cury01 #eb ,elixir ,lactopept9e1 #dc ,elixir ,novo-,hexam9e 7,up%] ,smi?71 ,reports ,c\ncil ,ph>m4 ,*em41 #aiag1 p4 #adb2 ,reports ,*em4 ,lab41 #aiag1 p4 #gj4 ,elixir ( ,bitt] ,w9e1 ,tr9]'s ,am]ican1 #aci ,elixir ( ,bitt] ,w9e1 ,tr9]'s ,am]ican 7,jos4 ,tr9]71 ,! ,j\rnal1 ,july #ad1 #aiag1 p4 #aci2 ,reports ,c\ncil ,ph>m4 ,*em41 p4 #cf4 ,elixir ( ,bu*u & ,hyoscyamus ,comp\nd1 ,tyree's1 #eg ,elixir ,secretog51 #ge ,empyr(orm 7,s*]+ ,glatz1 ,inc471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiah1 p4 #ee4 ,emulsio ,m9]ole9 7,t4 ,r4 ,d4 ,b>se ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #afi4 ,emulsio ,ph5-,oleum 7,t4 ,r4 ,d4 ,b>se ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #afi4 ,endo>san1 #dce ,endosal1 #dce ,endot9 7,morg5/]n ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiad1 p4 #acf4 ,enesol 7,e4 ,f\g]a ,co41 ,inc471 ,! ,j\rnal1 ,july #bf1 #aiac1 p4 #bic4 ,ent]onol 7,ent]onol ,co471 ,! ,j\rnal1 ,m>* #ba1 #aijh1 p4 #igg2 ,reports ,*em4 ,lab41 #aiji1 p4 #fd2 ,propag&a1 ed4 #i1 p4 #bid4 ,epilepsy1 ,di-,crotal9 treatm5t1 #dfe ,episan 7,gaynor-,bag/ad ,co47 ,! ,j\rnal1 ,sept4 #be1 #aiae1 p4 #aacj2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #afd4 ,epsom ,salt ,flavor+ a 8discov]y01 #agi ,ergoapiol 7,m>t9 ,h4 ,smi? ,co471 ,! ,j\rnal1 ,dec4 #ab1 #aiad1 p4 #badi2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiad1 p4 #fd2 ,propag&a1 ed4 #i1 p4 #hb4 ,ergone 7,p>ke1 ,davis ,co471 ,! ,j\rnal1 ,oct4 #g1 #aiaa1 p4 #abaa2 ,oct4 #ad1 #aiaa1 p4 #acjb4 ,ergotole 7,%>p ,dohme71 ,! ,j\rnal1 ,oct4 #g1 #aiaa1 p4 #abaa2 ,oct4 #ad1 #aiaa1 p4 #acjb4 ,erl+1 ,a4 ,e41 & ! ,alli$ ,m$ical ,associations ( ,am]ica1 #dhh ,erl+1 ,a4 ,e41 & ! ,physicians' ,drug ,syndicate1 #dcb ,erpiol1 ,dr4 ,s*rad] 7,wm4 ,s4 ,m]rell ,*emical ,co471 ,! ,j\rnal1 ,june #c1 #aiaa1 p4 #afgj2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiaa1 p4 #ah2 ,propag&a1 ed4 #i1 p4 #hc4 ,eskay's ,neuro ,phosphates1 #adf ,e/iv91 #dff ,e/iv9 7,s*ieffel9 & ,company71 ,! ,j\rnal1 ,nov4 #ab1 #aiba1 p4 #aeie4 ,e!r1 ,ane/hesia 7,cotton ,process7 7,du ,pont ,*emical ,works71 ,! ,j\rnal1 ,feb4 #ba1 #aibj1 p4 #edd2 ,may #bb1 #aibj1 p4 #adgd4 ,e!r1 ,cotton ,process1 #dba ,e?ics1 secret rem$ies & ! pr9ciples (1 #ega ,eucalyptol1 ,*lor9at$1 comp>ison ( ,*lorlyptus )1 #bha ,eucalyptus1 toxicity exp]im5ts1 #bhe ,euca-,mul 7,! ,edw>d ,g4 ,b9tz ,co471 ,! ,j\rnal1 ,oct4 #bi1 #aiba1 p4 #adch4 ,eumict9e1 #bfb ,eumict9e 7,geo4 ,j4 ,wallau1 ,inc471 ,! ,j\rnal1 ,feb4 #ba1 #aibj1 p4 #edb2 ,reports ,c\ncil ,ph>m4 ,*em41 #aibj1 p4 #g4 ,eunatrol 7,c4 ,bis*(f ,co471 ,! ,j\rnal1 ,feb4 #bb1 #aijh1 p4 #fbg4 ,eupeptic ,hypophosphites1 #hc ,eupeptic ,hypophosphites 7,nelson1 ,bak] ,co471 ,! ,j\rnal1 ,sept4 #b1 #aiaf1 p4 #gfa2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiaf1 p4 #ae4 ,eusoma 7,eusoma ,ph>maceutical ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #ch4 ,expurgo ,anti-,diabetes 7,expurgo ,mfg4 ,co471 ,! ,j\rnal1 ,jan4 #bd1 #aiad1 p4 #cab2 ,reports ,*em4 ,lab41 #aiad1 p4 #bg2 ,propag&a1 ed4 #i1 p4 #bii4 ,expurgo ,lapis 7,expurgo ,mfg4 ,co471 ,! ,j\rnal1 ,nov4 #h1 #aiac1 p4 #agcc4 ,extract ( ,r$ ,bone ,m>r[ 7,arm\r71 #bac ,fair*ild ,bros4 ,fo/]-- ,c>m9zym1 #aid ,holad9 & ,bile ,salt ,mixtures1 #bjg ,leci?91 #ec ,false ,unicorn1 ,! ,j\rnal1 ,nov4 #bg1 #aiji1 p4 #ahcf2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiji1 p4 #adf2 ,propag&a1 ed4 #i1 p4 #hd4 ,f>bw]ke-,hoe*/ ,co4-- ,proca9 7,novoca971 #cee1 #ceg1 #cge ,?reat5s physician ) suit = publi%+ unfavorable report ( its product1 #egj1 #ega ,febrisol 7,! ,tild5 ,co471 ,! ,j\rnal1 ,june #bi1 #aiab1 p4 #bjdc4 ,febri-,tone 7,ar?ur ,pet] ,co471 ,! ,j\rnal1 ,feb4 #a1 #aijh1 p4 #cgi4 ,fell[s' ,syrup & o!r prep>ations ( ,hypophosphites1 #cie ,fell[s' ,syrup ( ,hypophosphites1 #hb ,f]m5lactyl 7,anglo-,am]ican ,ph>macal ,co41 ,ltd471 ,! ,j\rnal1 ,jan4 #cj1 #aiji1 pp4 #cgb1 #cig4 ,f]ric ,ars5ite1 ,soluble1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #cj4 ,f]ric ,cacodylate1 #bib ,f]ric ,cacodylate1 ,reports ,c\ncil ,ph>m4 ,*em41 #aibj1 p4 #fb4 ,f]ritonic-,woods 7,william ,a4 ,web/] ,company71 ,! ,j\rnal1 ,oct4 #ah1 #aiai1 p4 #abca4 ,f]riv9e1 #add ,f]riv9e 7,e4 ,f\g]a ,co41 ,inc471 ,! ,j\rnal1 ,sept4 #h1 #aiag1 p4 #hda2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiag1 p4 #di4 ,figwort1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #db4 ,filud9e1 #da ,filud9e 7,geo4 ,j4 ,wallau1 ,inc471 ,! ,j\rnal1 ,sept4 #ah1 #aiae1 p4 #ajde2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #aef4 ,firolyptol ,pla91 #abj ,firolyptol ,pla9 7,! ,tild5 ,co474 ,! ,j\rnal1 ,feb4 #ag1 #aiag1 p4 #efd2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiag1 p4 #h4 ,firolyptol ) ,kreosote1 #abj ,firolyptol ) ,kreosote 7,! ,tild5 ,co471 ,! ,j\rnal1 ,feb4 #ag1 #aiag1 p4 #efd2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiag1 p4 #di4 ,firwe91 #aai ,firwe9 7,! ,tild5 ,co471 ,! ,j\rnal1 ,feb4 #ag1 #aiag1 p4 #efd2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiag1 p4 #g4 ,fl9t1 ,eaton & ,company--,quassia ,comp\nd ,tablets1 #cjf ,fl[]1 ,a4 ,h41 & ! ,alli$ ,m$ical ,associations ( ,am]ica1 #dhi ,=al1 #bjd ,=al 7,=al ,products ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiah1 p4 #ee4 ,=maldehyde ,loz5ges1 #bce ,=maldehyde ,loz5ges1 ,! ,j\rnal1 ,oct4 #d1 #aiai1 p4 #ajgg2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiai1 p4 #cb4 ,=mam9t1 #cc ,=mam9t 7,a4 ,wulf+ ,co471 ,! ,j\rnal1 ,jan4 #bg1 #aiab1 p4 #bie2 ,feb4 #bd1 #aiab1 p4 #egb2 ,aug4 #bh1 #aiae1 p4 #haf2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #fd2 ,propag&a1 ed4 #i1 p4 #cjc4 ,=mic ,acid1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiba1 p4 #be4 ,=mic9 7,kalle ,color ,*emical ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiai1 p4 #gf4 ,=mid9 7,p>ke1 ,davis ,co471 ,! ,j\rnal1 ,sept4 #e1 #aijh1 p4 #hah2 ,reports ,c\ncil ,ph>m4 ,*em41 #aije-h1 pp4 #afd1 #aib2 #aiab1 p4 #dh4 ,=mitol ,tablets1 #bcf1 #bga ,=mitol ,tablets 7,e4 ,l4 ,pat* ,co471 ,! ,j\rnal1 ,oct4 #d1 #aiai1 p4 #ajgg2 ,june #ai1 #aibj1 p4 #agcj2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiai1 p4 #cd2 #aibj1 p4 #bj2 ,reports ,*em4 ,lab41 #aibj1 p4 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,p]tussis-,comb9$-,bact]9 7,! ,abbott ,laboratories71 ,! ,j\rnal1 ,june #bb1 #aiah1 p4 #aifg2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiah1 p4 #aa4 ,pet]1 ,ar?ur1 ,co4--,syrupus ,roborans 7,syrup ,hypophosphites ,comp4 ) ,qu991 ,/ry*n9 & ,manganese71 #hb ,petrolatum1 ,liquid1 #ebf ,petrolatum1 ,liquid1 ,iod9 91 #cfg ,petrolatum1 ,liquid1 propriet>y names =1 #ee ,petrolatum1 liquid1 solubility ( ,iod9 91 #cdd ,ph>maceutical ,b>nums1 #ede ,ph>macopeia1 ! ,n9? ,dec5nial ,revision1 #edf ,phecolates 7,f4 ,waldo ,:itney71 ,! ,j\rnal1 ,nov4 #ba1 #aiad1 p4 #ahgj2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiad1 p4 #abg2 ,propag&a1 ed4 #i1 p4 #agd4 ,phecolax 7,f4 ,waldo ,:itney71 ,! ,j\rnal1 ,nov4 #ba1 #aiad1 p4 #ahgj2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiad1 p4 #abg2 ,propag&a1 ed4 #i1 p4 #agd4 ,phecotones 7,f4 ,waldo ,:itney71 ,! ,j\rnal1 ,nov4 #ba1 #aiad1 p4 #ahgj2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiad1 p4 #abg2 ,propag&a1 ed4 #i1 p4 #agd4 ,phecozymes 7,f4 ,waldo ,:itney71 ,! ,j\rnal1 ,nov4 #ba1 #aiad1 p4 #ahgj2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiad1 p4 #abg2 ,propag&a1 ed4 #i1 p4 #agd4 ,ph5ale9 7,pax ,*emical ,co471 ,! ,j\rnal1 ,april #cj1 #aiaj1 p4 #adeh2 ,propag&a1 ed4 #i1 p4 #cdd4 ,ph5alg91 #cic ,ph5alg9 7,etna ,*emical ,co471 ,! ,j\rnal1 ,june #c1 #aije1 p4 #agia2 ,jan4 #bg1 #aiab1 p4 #bic2 ,feb4 #h1 #aiah1 p4 #ccg2 ,reports ,c\ncil ,ph>m4 ,*em41 #aije-h1 p4 #h2 ,propag&a1 ed4 #i1 pp4 #aj1 #cce4 ,ph5etidyl-,acetph5etid9 ,hydro*lorid 7,holoca9 ,hydro*lorid71 #cgb ,ph5o-,bromate 7,ph5o-,bromate ,co471 ,! ,j\rnal1 ,july #ad1 #aijf1 p4 #abe2 ,april #ah1 #aijh1 p4 #abhb2 ,propag&a1 ed4 #i1 p4 #cdc4 ,ph5ol1 ,me?yl-,ph5ol ,s]um 7,cano71 #bea ,ph5ol ,s]um1 ,normal 7,cano71 #bea ,ph5ol ,sodique 7,hance ,bros4 ,:ite71 ,! ,j\rnal1 ,nov4 #i1 #aijg1 p4 #afag2 ,reports ,c\ncil ,ph>m4 ,*em41 #aije-h1 p4 #ii2 ,propag&a1 ed4 #i1 p4 #age4 ,ph5olax ,waf]s 7,upjohn ,co471 ,! ,j\rnal1 ,april #cj1 #aiaj1 p4 #adeh2 ,propag&a1 ed4 #i1 p4 #cdd4 ,ph5olph?ale9 ,laxative 7,el ,z]nac ,co471 ,! ,j\rnal1 ,april #cj1 #aiaj1 p4 #adeh2 ,propag&a1 ed4 #i1 p4 #cdd4 ,ph5ylc9*on9ic ,acid1 ,u4 ,s4 ,p41 #cgc ,phillips' ,phospho-,muriate ( ,qu99e ,comp41 #aig ,phosphates1 ,:eel]'s ,tissue1 #abi1 #dfc ,phosphoglyc]ate ( ,lime 7,*apoteaut71 #ie ,phosphoglyc]ate ( ,lime 7,*apoteaut7 7,e4 ,f\g]a & ,co41 ,inc471 ,! ,j\rnal1 ,sept4 #cj1 #aiaf1 p4 #ajcd2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiaf1 p4 #ce4 ,phospho-,muriate ( ,qu99e ,comp41 ,phillips'1 #aig ,phospho-,muriate ( ,qu99e ,comp4-,phillips 7,*>les ,h4 ,phillips ,*emical ,co471 ,! ,j\rnal1 ,oct4 #ai1 #aiah1 p4 #acce2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiah1 p4 #cb4 ,phosphorc9 ,comp\nd1 #id ,phosphorc9 ,comp\nd 7,organic ,products ,company71 ,! ,j\rnal1 ,sept4 #cj1 #aiaf1 p4 #ajcc2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiaf1 p4 #cd4 ,phosphorus1 ,amorph\s1 ,! ,j\rnal1 ,m>* #g1 #aiad1 p4 #gic2 ,m>* #bh1 #aiad1 p4 #ajcc2 ,propag&a1 ed4 #i1 p4 #dgh4 ,phosphorus1 ,amorph\s1 ,pill1 ,s4 ,d4 7,%>p ,dohme71 ,! ,j\rnal1 ,m>* #g1 #aiad1 p4 #gic2 ,m>* #bh1 #aiad1 p4 #ajcc2 ,propag&a1 ed4 #i1 #dgh4 ,phosphorus ,comp\nd1 ,iron & ,ars5ic1 ,hypod]mic ,solution ,no4 #ac1 #bge ,phosphorus ,tonic1 ,comp\nd1 ,d[d's 7,! ,ri*>dson ,company71 ,! ,j\rnal1 ,dec4 #bj1 #aiac1 p4 #bbeh2 ,propag&a1 ed4 #i1 p4 #dgf4 ,phospho-,vanadiol 7,vanadium ,*emical ,co471 ,! ,j\rnal1 ,jan4 #ah1 #aiac1 p4 #bbe2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiac1 p4 #g2 ,propag&a1 ed4 #i1 p4 #bji4 ,phylacog5s1 #dda ,phylacog5s 7,p>ke1 ,davis ,co471 ,! ,j\rnal1 ,feb4 #a1 #aiac1 p4 #chd2 ,feb4 #bb1 #aiac1 pp4 #fjb1 #fae2 ,m>* #ae1 #aiac1 p4 #hdi2 ,aug4 #bi1 #aiad1 p4 #ghe2 ,nov4 #ae1 #aiai1 p4 #aedb2 ,propag&a1 ed4 #i1 p4 #cdf4 ,physicians' ,drug ,syndicate--,?ymoz5e1 #dcb ,physician's ,league ( ,ill9ois1 #ebi ,physician's /ock 9 prescription products1 #edh ,phyt9 7,a4 ,klip/e9 ,co471 ,! ,j\rnal1 ,jan4 #cj1 #aiae1 p4 #def2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #aca2 ,propag&a1 ed4 #i1 p4 #agh4 ,pil4 ,casc>a ,comp\nd-,rob9s1 #aag ,pil4 ,casc>a ,comp4-,rob9s 7,a4 ,h4 ,rob9s ,co471 ,! ,j\rnal1 ,jan4 #bg1 #aiag1 p4 #cjc2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiaf1 p4 #dg4 ,pil4 ,mix$ ,treatm5t 7,*i*e/]71 #caj ,pil4 ,mix$ ,treatm5t 7,*i*e/]7 7,hillside ,*emical ,co471 ,! ,j\rnal1 ,oct4 #bb1 #aiba1 p4 #acee2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiba1 p4 #fj4 ,p9eal ,gl&-,arm\r1 ,desiccat$ 7,arm\r ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiah1 p4 #fi4 ,p9eal ,gl&1 ,desiccat$1 ,arm\r1 #bac ,p9eal ,gl&1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiah1 p4 #fi4 ,p9eal ,gl& ,tablets--,arm\r1 #bac ,p9eoleum adv]tis+ me?ods1 #ddb ,p9eoleum 7,! ,p9eoleum ,company71 ,! ,j\rnal1 ,nov4 #a1 #aiai1 p4 #achj4 ,p9us ,canad5sis1 ,k5n$y's1 ,d>k3 ,see ,d>p94 ,pip]az9e1 #bad ,pip]az9e 7,! ,bay] ,co41 ,inc471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiah1 p4 #gj4 ,pip]az9e ,wat] 7,lehn ,f9k71 ,! ,j\rnal1 ,feb4 #bi1 #aijh1 p4 #gjd4 ,pituit>y ,extract 9 labor1 #eej ,pituit>y ,gl& ,prep>ations1 #edi ,pituitr91 #eej ,pix ,cresol 7,pix ,cresol ,*emical ,co471 ,! ,j\rnal1 ,june #aj1 #aiaa1 p4 #agch2 ,reports ,*em4 ,lab41 #aiaa1 p4 #cg2 ,propag&a1 ed4 #i1 p4 #bdg4 ,plac5to-,mamm>y ,comp41 ,caps1 #bai ,plantex1 ,proteog5 ,no4 #a 7,plantex7 = canc]1 #bbg ,plasmon 7,plasmon ,milk ,products ,co471 ,reports ,*em4 ,lab41 #aiad1 p4 #hh4 ,platt's ,*lorides1 #bfc ,platt's ,*lorides 7,h5ry ,b4 ,platt71 ,! ,j\rnal1 ,m>* #bg1 #aibj1 p4 #ijc2 ,reports ,*em4 ,lab41 #aibj1 p4 #bh2 ,reports ,c\ncil ,ph>m4 ,*em41 #aibj1 p4 #h4 ,plurasav1 ,"y's 7,! ,plurasav ,co41 ,columbus1 ,ohio71 ,reports ,c\ncil ,ph>m4 ,*em41 #aiah1 p4 #hb4 8,plurigl&ul>0 mixtures1 #bah ,pluto ,spr+ ,wat]1 ,conc5trat$ 7,fr5* ,lick ,spr+s ,hotel ,co471 ,! ,j\rnal1 ,m>* #bi1 #aiac1 p4 #ajac4 ,pneumonia1 camphor 91 #beg ,pneumo-,/aph-,/rep4 ,bact]91 ,special ,bact]ial ,vacc9e ,no4 #c1 #bed ,pneumo-,/aph-,/rep-,coli ,bact]91 ,special ,bact]ial ,vacc9e ,no4 #d1 #bed ,pneumo-,/rep4 ,bact]91 ,special ,bact]ial ,vacc9e ,no4 #aa1 #bed ,pneumo-,/rep-,s]um 7,h4 ,k4 ,mul=d ,co471 ,! ,j\rnal1 ,jan4 #ca1 #aibj1 p4 #cdb4 ,pollant91 ,fall 7,fritzs*e ,bros471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiaf1 p4 #fi4 ,pollant9 ,p[d]1 ,fall 7,fritzs*e ,bros471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiaf1 p4 #fi4 ,poll5 ,antig5 7,l$]le ,antitox9 ,laboratories71 ,reports ,c\ncil ,ph>m4 ,*em41 #aiah1 p4 #fe4 ,poll5 ,antig5-,l$]le 7,fall ,type7 7,l$]le ,antitox9 ,laboratories71 ,reports ,c\ncil ,ph>m4 ,*em41 #aiba1 p4 #de4 ,poll5 ,antig5-,l$]le 7,spr+ ,type7 7,l$]le ,antitox9 ,laboratories71 ,reports ,c\ncil ,ph>m4 ,*em41 #aiba1 p4 #de4 ,ponca ,comp\nd1 #bh ,ponca ,comp\nd 7,melli] ,drug ,co471 ,! ,j\rnal1 ,july #ag1 #aiae1 p4 #bfi2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #df2 #aiad1 p4 #eh4 ,poslam 7,em]g5cy ,laboratories71 ,! ,j\rnal1 ,may #bb1 #aiji1 p4 #afgh2 ,reports ,*em4 ,lab41 #aiji1 p4 #be4 ,potassium ,iodo-,resorc9 ,sulphonate1 ,! ,j\rnal1 ,feb4 #aa1 #aiaa1 p4 #dda2 ,reports ,*em4 ,lab41 #aiaa1 p4 #ba4 ,prep>$ ,gre5 ,bone1 ,russell1 #acd ,prescription products1 physician's /ock 91 #edh ,probil9 ,pills 7,s*]+ ,glatz1 ,inc471 ,! ,j\rnal1 ,aug4 #bd1 #aijg1 p4 #gjb2 ,nov4 #b1 #aijg1 p4 #aeda2 ,reports ,c\ncil ,ph>m4 ,*em41 #aije-h1 p4 #gj2 ,propag&a1 ed4 #i1 p4 #cdd4 ,proca9-,abbott1 #cef1 #cgg ,proca9 7,calco71 #cgg ,proca9 7,f>bw]ke-,hoe*/ ,co471 #ceg1 #cgg ,proca9 7,metz71 #cgg ,proca9 7,novoca971 #cge ,proca9-,novoca9 br&1 #cef ,proca9 ,rector1 #cef1 #cgg ,proca91 /&>dization (1 & exam9ation ( m>ket supply1 #cee ,propriet>ies1 :y !y fl\ri%1 #eeb ,propriet>y m$ic9e1 secret rem$ies & ! pr9ciples ( e?ics1 #ega ,pro/oid 7,l[5?al71 #ebh ,proteal ,!rapy1 #did 8,proteal ,!rapy0 & ,h5ry ,smi? ,williams1 #ddc ,proteals 7,h5ry ,smi? ,williams71 ,! ,j\rnal1 ,july #f1 #aiah1 p4 #eh4 ,prote9 ,!rapy1 ,nonspecific1 #ecf ,proteog5 ,no4 #a 7,plantex7 = canc]1 #bbg ,proteog5 ,no4 #b = rheumatism1 #bbg ,proteog5 ,no4 #c = tub]culosis1 #bbg ,proteog5 ,no4 #d = hay fev] & bron*ial a/hma1 #bbg ,proteog5 ,no4 #e = d]matoses1 #bbg ,proteog5 ,no4 #f = *lorosis1 #bbg ,proteog5 ,no4 #g = second>y anemia1 #bbg ,proteog5 ,no4 #h = p]nici\s anemia1 #bbg ,proteog5 ,no4 #i = goitre1 #bbg ,proteog5 ,no4 #aj = syphilis1 #bbg ,proteog5 ,no4 #aa = gonorrhea1 #bbg ,proteog5 ,no4 #ab = influ5za & pneumonia1 #bbg ,proteog5s1 #bbf1 #dde ,proteog5s 7,wm4 ,s4 ,m]rell ,co471 ,! ,j\rnal1 ,july #ab1 #aiai1 pp4 #aji & #abh2 ,july #bf1 #aiai1 p4 #bhh2 ,sept4 #f1 #aiai1 p4 #gha2 ,sept4 #bg1 #aiai1 p4 #ajjj2 ,oct4 #aa1 #aiai1 p4 #aaeb2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiai1 p4 #bj4 ,proteog5s1 alleg$ endorsem5t repudiat$1 #ddf ,proteog5s1 ,dr4 ,broeman's f9al report on1 #dej ,protonucle91 #ei ,protonucle9 7,re$ ,c>nrick ,co471 ,! ,j\rnal1 ,oct4 #e1 #aijg1 p4 #aaih2 ,oct4 #bd1 #aijh1 p4 #achh2 ,jan4 #a1 #aiaf1 p4 #dh2 ,reports ,c\ncil ,ph>m4 *em41 #aije-h1 p4 #gi2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #ij2 ,propag&a1 ed4 #i1 p4 #cdh4 ,protonucle9 ,beta1 #ei ,protonucle9 ,beta 7,re$ ,c>nrick ,co471 ,! ,j\rnal1 ,jan4 #a1 #aiaf1 p4 #dh2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #ij4 ,prunoids 7,sultan ,drug ,co471 ,! ,j\rnal1 ,april #cj1 #aiaj1 p4 #adeh2 ,jan4 #b1 #aiae1 p4 #ga2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiad1 p4 #acc2 ,reports ,*em4 ,lab41 #aiad1 p4 #fc2 ,propag&a1 ed4 #i1 pp4 #agh1 #cdd4 ,psora 7,pix ,cresol ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #ci4 ,pulvane1 #dej ,pulvoids1 ,calcylates1 #he ,pulvoids1 ,calcylates 7,drug ,products ,company71 ,! ,j\rnal1 ,sept4 #i1 #aiaf1 p4 #hbg2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiaf1 p4 #ah4 ,pulvoids ,calcylates ,comp\nd1 #bbf ,pulvoids ,calcylates ,comp\nd 7,! ,drug ,products ,co41 ,inc471 ,! ,j\rnal1 ,june #ad1 #aiai1 p4 #aghd2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiai1 p4 #ai4 ,pulvoids ,natrium ,comp\nd1 #ajh ,pulvoids ,natrium ,comp\nd 7,drug ,products ,company1 ,inc471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiaf1 p4 #fi4 ,purdue ,fr$]ick ,company--,gray's ,glyc]9e ,tonic1 #bd ,purg5 7,lehn ,f9k71 ,! ,j\rnal1 ,jan4 #e1 #aijg1 p4 #fd2 ,sept4 #ad1 #aijg1 p4 #ied2 ,propag&a1 ed4 #i1 p4 #cdi4 ,pyo-atox9 7,h4 ,o4 ,hurley71 ,! ,j\rnal1 ,feb4 #ad1 #aiad1 p4 #eeb2 ,reports ,*em4 ,lab41 #aiad1 p4 #cb2 ,propag&a1 ed4 #i1 p4 #cej4 ,pyocyaneus ,bacillus ,vacc9e1 ,! ,j\rnal1 ,may #ah1 #aiah1 p4 #adhf2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiah1 p4 #aa4 ,pyxol 7,b>rett ,mfg4 ,co471 ,! ,j\rnal1 ,feb4 #bc1 #aiah1 p4 #eei4 ,qu>tonol ,tablets1 #id ,qu>tonol ,tablets 7,s*]+ & ,glatz1 ,inc471 ,! ,j\rnal1 ,sept4 #cj1 #aiaf1 p4 #ajcc2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiaf1 p4 #cd4 ,quassia ,comp\nd ,tablets1 #cjf ,quassia ,comp\nd ,tablets 7,fl9t1 ,eaton & ,company71 ,! ,j\rnal1 ,july #i1 #aiba1 p4 #ada2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiba1 p4 #fd4 ,que5 ( ! ,mead[1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #de4 ,qu9a ,la,roche 7,e4 ,f\g]a ,co41 ,inc471 ,! ,j\rnal1 ,m>* #ba1 #aijh1 p4 #igh4 ,qu99 & ,urea ,hydro*lorid1 #dfg ,qu99 ,ars5ate1 ,! ,j\rnal1 ,july #af1 #aiaj1 p4 #cbe2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiaj1 p4 #gc4 ,qu99 ,glyc]ophosphate1 ,reports ,*em4 ,lab41 #aiab1 p4 #ajg4 ,qu99 ,laxative ,tablets1 #eff ,qu99e ,comp41 ,phillips' ,phospho-,muriate (1 #aig ,rabbit-,foot ,!rapy1 #ega ,radelium & ,radelium ,g5]ator 7,radio-,active ,wat] ,company71 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #abh4 ,radio-,rem1 #gi ,radio-,rem ,outfit ,no4 #b1 ,no4 #c 7,s*ieffel9 ,co471 ,! ,j\rnal1 ,aug4 #ai1 #aiaf1 p4 #fca2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiaf1 p4 #i4 ,radio-,rem ,outfit ,c 7,s*ieffel9 ,co471 ,! ,j\rnal1 ,aug4 #ai1 #aiaf1 p4 #fca2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiaf1 p4 #i4 ,radium ,solution = ,intrav5\s ,use1 ,/&>d 7,radium ,*emical ,co471 ,! ,j\rnal1 ,june #bf1 #aiae1 p4 #baef2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #adg4 ,rahtj51 ,philip1 & 8 discov]ies1 #eec ,ra9ey1 ,james ,m41 #ebh ,rattlesnake-,v5om1 ,! ,j\rnal1 ,m>* #ae1 #aiac1 p4 #hej2 ,m>* #bi1 #aiac1 p4 #ajja2 ,june #g1 #aiac1 p4 #ahaa4 ,rector ,*emical ,company-- ,b>bital1 #cga ,proca9-,rector1 #cef1 #cgg ,r$ ,bone-,m>r[--,arm\r1 ,extract (1 #bac ,r$ ,bone-,m>r[1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiah1 p4 #fi4 ,r$ ,bone-,m>r[--,arm\r1 ,extract ( 7,arm\r ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiah1 p4 #fi4 ,r$ ,m]curic ,iodid 7,m]cury ,b9iodid7 comp>ative symptoms result+ f use ( sev]al oily susp5sions (1 #abc ,r$9tol 7,johnson ,johnson71 ,! ,j\rnal1 ,july #bh1 #aiag1 p4 #cjf4 ,re$ & ,c>nrick--,protonucle9 & ,protonucle9 ,beta1 #ei ,re9s*ild ,*emical ,company--,iodo-,mangan1 #ajf ,res9ol 7,res9ol ,*emical ,co471 ,! ,j\rnal1 ,nov4 #f1 #aiji1 p4 #aegh2 ,propag&a1 ed4 #i1 p4 #ceb4 ,resor-,bisnol 7,resor-,bisnol ,*emical ,co471 ,! ,j\rnal1 ,june #a1 #aiab1 p4 #agjf2 ,reports ,*em4 ,lab41 #aiab1 p4 #he2 ,propag&a1 ed4 #i1 p4 #cec4 ,respirazone 7,! ,tild5 ,company71 ,! ,j\rnal1 ,june #ad1 #aiac1 p4 #ahii4 ,re/orative ,capsules1 #dbe ,rheumalg9e1 #bc ,rheumalg9e 7,eli ,lilly ,co471 ,! ,j\rnal1 ,june #bf1 #aiae1 p4 #baef2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #adh4 ,rheumatic & ,g\t ,pills1 ,de ,sanctis'1 #cfc ,rheumatic ,bact]9 7,mix$71 7,no4 #dg71 ,swan's 7,swan-,my]s ,co471 ,! ,j\rnal1 ,nov4 #f1 #aiae1 p4 #affb2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #afj4 ,rheume ,olum 7,rheumeolum ,*emical ,co471 ,! 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,c\ncil ,ph>m4 ,*em41 #aiad1 p4 #acf4 ,vacc9e-,lilly1 ,influ5za ,mix$1 #ahg ,vacc9e1 ,m4 ,cat>rhalis-,comb9$-,bact]91 #ahd ,vacc9e1 ,non-,virul5t ,tub]cle ,bacillus 7,g4 ,h4 ,%]man74-- ,see ,tub]cle ,vacc9e1 ,%]man's ,non-,virul5t4 ,vacc9e1 ,no4 #b 7,/aph-,/rep4 ,bact]971 ,special ,bact]ial1 #bed ,vacc9e ,no4 #c 7,pneumo-,/aph-,/rep4 ,bact]971 ,special ,bact]ial1 #bed ,vacc9e ,no4 #d 7,pneumo-,/aph-,/rep-,coli ,bact]971 ,special ,bact]ial1 #bed ,vacc9e ,no4 #e 7,influ5za ,comb9$ ,bact]971 ,special ,bact]ial1 #bed ,vacc9e ,no4 #aa 7,pneumo-,/rep4 ,bact]971 ,special ,bact]ial1 #bed ,vacc9e ,no4 #ae 7,comb9$ ,:oop+ ,c\gh ,bact]971 ,special ,bact]ial1 #bed ,vacc9e ,no4 #af 7,mix$ ,gonococcus ,bact]971 ,special ,bact]ial1 #bed ,vacc9e1 ,no4 #dj1 ,%]man's ,mix$1 #ahh ,vacc9e1 ,p]tussis-,comb9$-,bact]91 #ahe ,vacc9e1 ,/reptococcus-,rheumaticus-,comb9$-,bact ]91 #ahe ,vacc9es-,abbott1 ,mix$1 #ahd ,vacc9es & ,s]ums1 #eba ,vacc9es = 8,colds01 #egc 8,vacc9es0 9 toxic conditions1 #efj ,vacc9es1 ,influ5za1 #ebj ,vacc9es1 ,mix$1 ,! ,j\rnal1 ,june #bb1 #aiah1 p4 #aifg2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiah1 p4 #aa4 ,see also3 ,b4 ,coli-,comb9$-,bact]92 ,cat>rhal ,vacc9e-,comb9$-,lilly2 ,influ5za ,mix$ ,vacc9e-,lilly2 ,influ5za ,s]obact]9 ,mix$-,mul=d2 ,m4 ,cat>rhalis-,comb9$ ,bact]92 ,mix$ ,vacc9e ,no4 #dj1 ,%]man's2 ,p]tussis-,comb9$- ,bact]92 ,/reptococcus-,rheumaticus-,comb9$-,bact ]92 ,/reptococcus-,viridans-,comb9$-,bact]94 ,vacc9es1 ,sev]al 8,mix$01 #ahd ,van ,horn & ,sawtell--,k-,y ,lubricat+ ,jelly1 #adg ,vanadic ,acid1 ,! ,j\rnal1 ,may #i1 #aijh1 p4 #aedh2 ,july #bd1 #aiji1 p4 #cji4 ,vanadiol 7,vanadium ,*emical ,co471 ,! ,j\rnal1 ,jan4 #ah1 #aiac1 p4 #bbe2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiac1 p4 #g2 ,propag&a1 ed4 #i1 p4 #bji4 ,vanadioseptol 7,vanadium ,*emical ,co471 ,! ,j\rnal1 ,jan4 #ah1 #aiac1 p4 #bbe2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiac1 p4 #g2 ,propag&a1 ed4 #i1 p4 #bji4 ,vanadium1 ,! ,j\rnal1 ,june #c1 #aiaa1 p4 #afdh4 ,vanadium ,solution = ,intrav5\s & 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,laboratories1 ,inc471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiag1 p4 #afc4 ,v-,e-,m ) ,i*?yol1 #afg ,v-,e-,m ) ,i*?yol 7,s*oonmak] ,laboratories1 ,inc471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiag1 p4 #afc4 ,v-,e-,m ) ,/e>ate ( ,z9c1 #afg ,v-,e-,m ) ,/e>ate ( ,z9c 7,s*oonmak] ,laboratories1 ,inc471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiag1 p4 #afc4 ,v5>s51 #dga ,v5>s5 7,intrav5\s ,products ,co471 ,! ,j\rnal1 ,may #bb1 #aiae1 p4 #aghj2 ,m>* #be1 #aiaf1 p4 #igh2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #eb2 ,reports ,*em4 ,lab41 #aiae1 p4 #hb2 ,propag&a1 ed4 #i1 p4 #bab4 ,v5calxod9e 7,intrav5\s ,products ,co471 ,! ,j\rnal1 ,feb4 #af1 #aiah1 p4 #dha4 ,v5od9e 7,intrav5\s ,products ,co474 ,! ,j\rnal1 ,june #bf1 #aiae1 p4 #baee2 ,m>* #be1 #aiaf1 p4 #bgh2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #ade2 ,propag&a1 ed4 #i1 p4 #bad4 ,v5om] 7,intrav5\s ,products ,co471 ,! ,j\rnal1 ,m>* #be1 #aiaf1 p4 #igh4 ,v5osal1 #afi1 #dce ,v5osal 7,intrav5\s ,products ,co471 ,! ,j\rnal1 ,jan4 #e1 #aiah1 p4 #dh2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiag1 p4 #aah2 ,reports ,*em4 ,lab41 #aiag1 p4 #eg4 ,v]acolate 7,m>cy ,co471 ,! ,j\rnal1 ,april #cj1 #aiaj1 p4 #adeh2 ,aug4 #a1 #aiad1 p4 #dbj2 ,april #bd1 #aiae1 p4 #addj2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #ada2 ,propag&a1 ed4 #i1 pp4 #baf1 #cdd4 ,v]acolate ) ,iron1 ,qu99e & ,/ry*n9e 7,m>cy ,co471 ,! ,j\rnal1 ,april #bd1 #aiae1 p4 #addj2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #ada4 ,v]acolate ) ,peps9 & ,pancreat9 7,m>cy ,co471 ,! ,j\rnal1 ,april #bd1 #aiae1 p4 #addj2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #ada4 ,v](orm ,g]micide 7,v](orm ,hygi5ic ,co471 ,! ,j\rnal1 ,nov4 #bb1 #aiac1 p4 #aibj2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiac1 p4 #bi4 ,v]onal1 #cga ,v]onal 7,b>bital71 #cgj ,v]onal-,sodium1 #cga ,viburn-,ov>o 7,ray ,*emical ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #df4 ,viburnum ,comp\nd1 ,hayd5's 7,new ,york ,ph>macal ,co471 ,! ,j\rnal1 ,aug4 #ca1 #aiab1 p4 #gce2 ,jan4 #bc1 #aiae1 p4 #cei2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiad1 p4 #ie2 ,propag&a1 ed4 #i1 pp4 #bah1 #dji4 ,viburnum ,comp\nd1 ,elixir 7,nelson1 ,bak] ,co471 ,! ,j\rnal1 ,aug4 #ca1 #aiab1 p4 #gce2 ,propag&a1 ed4 #i1 p4 #daj4 ,viburnum ,comp\nd 7,tablets71 7,p>ke1 ,davis ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #da4 ,viburnum ,comp\nd 7,tablet7 7,ut]9e ,tonic71 7,p>ke1 ,davis ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #df4 ,viburnum ,comp\nd 7,tablet7 7,smi?1 ,kl9e ,fr5* ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #df4 ,viburnum ,s$ative 7,fras] ,tablet ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #df4 ,viburnumal 7,l\isville ,ph>macal ,works71 ,! ,j\rnal1 ,aug4 #ca1 #aiab1 p4 #gce2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #dd2 ,propag&a1 ed4 #i1 p4 #daj4 ,vibut]o 7,f4 ,/e>ns ,co471 ,! ,j\rnal1 ,aug4 #ca1 #aiab1 p4 #gce2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #df2 ,propag&a1 ed4 #i1 p4 #daj4 ,vigoral 7,arm\r ,co471 ,! ,j\rnal1 ,jan4 #bc1 #aiji1 p4 #caa2 ,propag&a1 ed4 #i1 p4 #dgb4 ,v9 ,m>iani 7,m>iani ,co471 ,! ,j\rnal1 ,nov4 #bd1 #aijf1 p4 #agea2 ,reports ,c\ncil ,ph>m4 ,*em41 #aije-h1 p4 #bi2 ,propag&a1 ed4 #i1 p4 #bba4 ,v9um ,extract ,morrhuae1 ,/e>ns1 #ei ,violet ,ray ,g5]ator1 ,/]l+1 #egb ,virol 7,etna ,*emical ,co471 ,! ,j\rnal1 ,feb4 #bj1 #aiae1 p4 #fhc2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #acb2 ,propag&a1 ed4 #i1 p4 #bbe4 ,vitam9 ,b ,conc5trates & ,yea/ ,prep>ations1 #cba ,vitam9s3 _! di/ribution1 #efa ,vitaphos 7,! ,gra9 ,*emical ,company1 ,inc471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiba1 p4 #gd4 ,walk] ,ph>macal ,company--,succus ,c9]>ia ,m>itima1 #dee ,wallau1 ,george ,j41 ,inc4-- ,eumict9e1 #bfb ,filud9e1 #da ,jubol1 #ca ,sulfuryl ,monal1 #hf ,urodonal1 #cb ,wampole1 ,h4 ,k41 ,co4--,hypno-,bromic ,comp\nd1 #dcj ,w>m+ bottles1 ,sodium ,acetate 91 #cbi ,wat]1 ,buffalo ,li?ia ,spr+s 7,buffalo ,li?ia ,spr+s ,wat] ,co471 ,! ,j\rnal1 ,sept4 #ab1 #aijh1 p4 #ica4 ,wat] ,eryngo1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #dg4 ,web/] ,co41 ,william ,a4 & ! ,direct ,ph>maceutical ,co41 #efd ,weeks ,*emical ,company--,*lorlyptus1 #bgg ,we/]field's ,digitalis ,tablets1 #bae ,:eel]'s ,tissue ,phosphates1 #abi1 #dfc ,:ite1 ,g4 ,s41 & ! ,alli$ ,m$ical ,associations ( ,am]ica1 #dij ,:ite1 ,m>k1 ,goit] ,s]um ,laboratories--,m>k ,:ite ,goit] ,s]um & ,m>k ,:ite ,iod9iz$ ,oil1 #hg ,:ite ,sulphur ,salts 7,:ite ,sulphur ,spr+s1 ,inc471 ,! ,j\rnal1 ,nov4 #ba1 #aiad1 p4 #ahgj2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiad4 p4 #abh4 ,:it]uss 7,lubric ,oil ,co471 ,! ,j\rnal1 ,july #aj1 #aiae1 p4 #age4 ,:oop+ ,c\gh ,bact]91 ,comb9$1 ,special ,bact]ial ,vacc9e ,no4 #ae1 #bed ,wild ,indigo1 ,! ,j\rnal1 ,jan4 #bb1 #aiaj1 p4 #cjd2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiaj1 p4 #ai2 ,propag&a1 ed4 #i1 p4 #bjh4 ,wild ,yam1 ,! ,j\rnal1 ,jan4 #bb1 #aiaj1 p4 #cjd2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiaj1 p4 #aj2 ,propag&a1 ed4 #i1 p4 #bjh4 ,william ,f4 ,ko* ,canc] ,rem$y1 #dcg ,williams1 ,h5ry ,smi?1 & 8,proteal ,!rapy01 #ddc1 #did ,w9e1 ,*apoteaut's 7,e4 ,f\g]a ,co41 ,inc471 ,! ,j\rnal1 ,dec4 #ai1 #aiad1 p4 #bbdg2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiad1 p4 #gg2 ,propag&a1 ed4 #i1 p4 #fj4 ,w9e1 ,/e>ns' 7,f4 ,/e>ns ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #agg4 ,w9sl[ ,laboratory--,p9eoleum adv]tis+ me?ods1 #ddb ,w9?rop ,*emical ,company1 ,inc4-- ,el>son1 #bdh ,helmitol1 #bie ,woolley1 ,d4 ,e41 ,manag] ( ,cosmopolitan ,canc] ,rese>* ,society1 #dad ,worlds ,wond] ,rem$y 7,w4 ,w4 ,rem$y ,co41 ,sup]ior1 ,wis471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiah1 p4 #hb4 ,wulf+1 ,a41 ,company--,=mam9t1 #cc ,wye?1 ,john1 & ,bro!r-- ,hydras1 #if ,rob9ol1 #ie ,xanol 7,wm4 ,s4 ,m]rell ,*emical ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiaa1 p4 #fd4 ,x](orm1 #ceb ,x](orm-,heyd51 #baf1 #cdi ,y>br\gh1 ,*>les ,c4--,b9iodol1 #aba ,yea/1 #eff ,yea/ ,prep>ations & ,vitam9 ,b ,conc5trates1 #cba ,y]ba ,santa1 ,maltzyme )1 #baa ,yogurt 7,yogurt ,co471 ,! ,j\rnal1 ,jan4 #cj1 #aiji1 pp4 #cgb1 #cig4 ,yohimb9 ,spiegel 7,lehn ,f9k71 ,! ,j\rnal1 ,m>* #cj1 #aijg1 p4 #aabg4 ,zemacol 7,norwi* ,ph>macal ,co471 ,! ,j\rnal1 ,may #ad1 #aiaj1 p4 #afbf2 ,reports ,*em4 ,lab41 #aiaj1 p4 #db2 ,propag&a1 ed4 #i1 p4 #bei4 ,ziratol1 #adh ,ziratol 7,bri/ol-,my]s ,co471 ,! ,j\rnal1 ,oct4 #f1 #aiag1 p4 #aaia2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiag1 p4 #ee2 ,reports ,*em4 ,lab41 #aiag1 p4 #ea4 ,zyme-oid 7,oxy*lor9 ,*emical ,co471 ,! ,j\rnal1 ,may #bc1 #aijh1 p4 #agjf2 ,reports ,*em4 ,lab41 to #aiji1 p4 #cd2 ,propag&a1 ed4 #i1 p4 #bfa4 ,zymotoid1 ,arnold's 7,zymotoid ,co471 ,! ,j\rnal1 ,april #f1 #aiab1 p4 #ajcj2 ,reports ,*em4 ,lab41 #aiab1 p4 #fh2 ,propag&a1 ed4 #i1 p4 #dab4 ,spell+ v>iations3 am5orrhea_/am5orrhoea amp\le_/ampule_/ampul anaemia_/anemia analgetic_/analgesic any "o_/anyone ars5ph5olam9_/ars5o-ph5olam9 arsph5am9_/arsph5am9e bromid_/bromide c]ebral-sp9al_/c]ebro-sp9al_/c]ebrosp9al *lorid_/*loride coca9_/coca9e ,cod-,liv] ,oil_/,cod ,liv] ,oil die?yl5$iam5e_/die?yl5e-diam9e dioxid_/dioxide drams_/dra*ms dulness_/dullness envelop_/envelope e "o_/ev]yone ext5tion_/ext5sion =maldehyd_/=maldehyde gold5-seal_/gold5seal gonorrhoic_/gonorrheaic ,grip_/,grippe gu>anty_/gu>antee ,heitzman_/,heitzmann hexame?yl5etetram9_/hexame?yl5etetram9e_ /hexame?yl5e-tetram9e_/ hexam5?yl5etetram9 iodid_/iodide iod9_/iod9e mel5a_/mela5a oxid_/oxide ,p>res9e_/,p>es9e ph>macopeia_/ph>macopoeia po/-graduate_/po/graduate sanat>ium_/sanit>ium_/sanatorium sel5io-vanadium_/sel5ium-vanadium sequel_/sequelae_/sequella sulphurat$_/sulphuret$_/sulphurett$_/sul phurrett$ te*nique_/te*nic vitam9es_/vitam9s ,spell+ corrections3 accompani%$ -- accompli%$ accurtely -- accurately ace?ph5etid9 -- acetph5etid9 adv]tise+ -- adv]tis+ adv]tism5ts -- adv]tisem5ts alum9ium -- alum9um ,am]can -- ,am]ican amples -- ampules an ypure -- any pure & -- an & -- on ,anelgesic -- ,analgesic anitseptic -- antiseptic anodoyne -- anodyne anoht] -- ano!r aortis -- aortitis artifically -- artificially asosciat$ -- associat$ ,assimiliation -- ,assimilation at -- z attt5tion -- att5tion au!nic -- au!ntic au?or -- au?ors ,bacilus -- ,bacillus baillus -- bacillus ,b>bitol -- ,b>bital bee5 -- be5 b5efical -- b5eficial betanaphtol -- betanaph?ol betw5 -- betwe5 bibliograpy -- bibliography ,b+hampton -- ,b+hamton b9odide -- b9iodide ,botazzi -- ,bottazzi c>bonic -- c>bolic c>odylate -- cacodylate c>r] -- c>ri] c>?>tic -- ca?>tic *>act]i/c -- *>act]i/ic ,*autaqua -- ,*autauqua *efly -- *iefly ,*emi/y -- ,*emi/ry ,*lorilyptus -- ,*lorlyptus ,*oron -- ,*loron cities -- cites claims -- claim clipp+ -- clipp+s clorless -- colorless coeffieci5t -- coeffici5t ,collosal -- ,collosol compa9$ -- compla9$ compa9t -- compla9t compatable -- compatible ,compond -- ,comp\nd compo/ion -- composition ,conc]nng -- ,conc]n+ conditons -- conditions conection -- connection cone5trat$ -- conc5trat$ confrres -- confrres conn5ction -- connection con/itut5t7s7 -- con/itu5t7s7 ,contro -- ,control convicition -- conviction corespond5ce -- correspond5ce corpuscules -- corpuscles cry/al9e -- cry/all9e davantages -- advantages dep>m5t -- dep>tm5t de/royes -- de/roys develope -- develop diehylb>bituric -- die?ylb>bituric ,die?ylb>biutric -- ,die?ylb>bituric digtalis -- digitalis dirctory -- directory di/ate -- di/a/e di/ils -- di/ills does -- doses dulness -- dullness dy/5t]y -- dys5t]y ,ehlri* -- ,ehrli* ,electobioscope -- ,electrobioscope emipric -- empiric employe -- employee entil$ -- entitl$ ep]im5ts -- exp]im5ts esesntially -- ess5tially ess5tally -- ess5tially eucalytpus -- eucalyptus examation -- exam9ation extravant -- extravagant exurb]ant -- exub]ant ,f>bk]ke-,hoe*/ -- ,f>bw]ke-,hoe*/ ,f>bw]cke-,hoe*/ -- ,f>bw]ke-,hoe*/ ,f>bw]ke-,ho*e/ -- ,f>bw]ke-,hoe*/ ,f>bw]ke-,hoe*e/ -- ,f>bw]ke-,hoe*/ ,f>kw]ke -- ,f>bw]ke ,f]bw]ke -- ,f>bw]ke f9% -- f9i% ,firw9 -- ,firwe9 fitrate -- filtrate flgrant -- flagrant fluori% -- fl\ri% ,,fom -- ,,f =m -- f fradul5t -- fraudul5t ,frits*e -- ,fritzs*e gactric -- ga/ric galactogogic -- galactagogic galactogogue -- galactagogue ,galatagogue -- ,galactagogue ,giesecke -- ,gieseke ,glyecr9 -- ,glyc]9 ,go]+ -- ,goehr+ gonoccoccus -- gonococcus gual!ria -- gaul!ria guiacol -- guaiacol habtual -- habitual ,hallon -- ,hallion ,hcl -- ,h,cl he -- be ,hea? -- ,heal? hexam5?yl5am9 -- hexame?yl5am9 ,hexam5?yl5etetram9 -- ,hexame?yl5etetram9 ,hexame?yl5tetram9e -- ,hexame?yl5etetram9e ,higi5ic -- ,hygi5ic hundrance -- hundrance ,hussy -- ,hussey hydiodic -- hydriodic hydo*loric -- hydro*loric hy]pla/ic -- hy]pla/ic hyocyamus -- hyocyamus hyoscymus -- hyoscymus idod9 -- iod9 idosyncrasy -- idiosyncrasy inections -- injections +orance -- ignorance insommia -- insomnia intractions -- int]actions intramuscu>ly -- intramuscul>ly itme -- "t jubject -- subject le*i?9 -- leci?9 liklihood -- likelihood lisit$ -- li/$ ,,lypmh -- ,,lymph ,maganese -- ,manganese ,magnesim -- ,magnesium manufactur] -- manufactur]s ,mazaz9e -- ,magaz9e mecurial -- m]curial mecuric -- m]curic m$ic9ce -- m$ic9e ,metorrhagia -- ,metrorrhagia ,mey]s -- ,my]s m9imum -- m9im mixutre -- mixture monoceticacide/] -- monoaceticacide/] monoply -- monopoly ,naphtol -- ,naph?ol nap?al -- nap?ol ,nap?ol -- ,naph?ol neuralga -- neuralgia nirtic -- nitric ,nutrolactic -- ,nutrolactis ,o4 ,h4 -- ,a4 ,h4 odide -- iodide ,ophtalmol -- ,oph?almol or -- ( org9al -- orig9al pag -- page pamphet -- pamphlet p>ff9 -- p>aff9 p>m9ob5zoate -- p>am9ob5zoate p>ticu>ly -- p>ticul>ly pa/icity -- pla/icity pat5t -- pati5t ph>maceptical -- ph>maceutical ,ph>macopia -- ,ph>macopeia ph>macti/s -- ph>macti/s ph>mceutical -- ph>maceutical pho%ite -- phosphite ,phram4 -- ,ph>m4 physicial -- physical ,p9eolum -- ,p9eoleum ,p9oleum -- ,p9eoleum ,pitsburgh -- ,pittsburgh pitui>y -- pituit>y ,plurig &ul> -- ,plurigl&ul> ,pneumocci -- ,pneumococci ,pneumococccus -- ,pneumococcus pnuemonia -- pneumonia popul>ily -- popul>ly popul>y -- popul>ly po/ive -- positive ,p[] -- ,p[d] precipiate -- precipitate pref>e -- preface prep>atons -- prep>ations prescib$ -- prescrib$ prev\s -- previ\s pr9icple -- pr9ciple proc$ues -- proc$ures pr(esion -- pr(ession prop] ties -- prop]ties propond]ant -- prepond]ant ,proti] -- ,porti] ,protog5 -- ,proteog5 puport+ -- purport+ pyrog5ic -- pyog5ic qe/ions -- que/ions quantiatively -- quantitatively ,qu]ry -- ,qu]y ,qu9e -- ,qu99e radicle -- radical ,ra?j5 -- ,rahtj5 recom5dation -- recomm5dation recommm5d -- recomm5d recommm5d$ -- recomm5d$ refree -- ref]ee rememeb]$ -- rememb]$ ,rep>ts -- ,reports ressi/ance -- resi/ance re/rospect -- retrospect reults -- results ,rhatj5 -- ,rahtj5 sacc>9e -- sac*>9e same -- "s santorium -- sanatorium sci5tfic -- sci5tific sel59um -- sel5ium sel5o-vanadium -- sel5io-vanadium s]ies -- s]i\s ,%]+ -- ,s*]+ simiplicity -- simplicity specifially -- specifically ,/aphylococus -- ,/aphylococcus submit$ -- submitt$ submittt$ -- submitt$ sub/ane\s -- subcutane\s sup]nat5t -- sup]natant suport -- support syphilus -- syphilis ,syracue -- ,syracuse teasponful -- teaspoonful tehnic -- te*nic tetraoidid -- tetraiodid t -- ?an !>apeutic -- !rapeutic ?iome?yl>sniate -- ?iome?yl>s9ate ,?yroidect9 -- ,?yroidect9 tisssues -- tissues tisues -- tissues to -- too trav5\s -- intrav5\s tream5t -- treatm5t tremely -- extremely troat -- ?roat tub]cuclosis -- tub]culosis unbeliveable -- unbelievable va/y -- va/ly vially -- vitally ,wulflng -- ,wulf+ #bdj3b'a1 #ahhg4 -- #bdj3bia1 #ahhg4