,transcrib]'s notes3 ,9 ?is transcription1 pair$ equals symbols indicate bold text & pair$ und]scores d5ote italicis$ text4 ,a s+le und]score foll[$ by pair$ curly brackets indicates t ! enclos$ *>act]s are subscript$1 e4g4 9 ! *emical =mula ,c#c;,h#h,o#c4 ,footnotes are locat$ bel[ ! relevant p>agraphs4 ,! text conta9s uncommon *>act]s t w n necess>ily display correctly ) all view+ devices4 ,if "s ( ! *>act]s look abnormal1 fir/ ensure t ! device's "* encod+ is set to ,unicode 7,,utf-#h74 ,! default font might also ne$ to be *ang$ to a ,unicode font su* z ,arial ,unicode ,,ms1 ,deja,vu1 ,segoe ,,ui ,symbol or ,free,serif4 ,! book conta9s quotations1 comm5ts & reports relat+ to debates betwe5 m$ical au?orities & ph>maceutical suppli]s1 & ! text is =matt$ 9 su* a way 79 bo? ! orig9al & 9 ?is transcription7 z to help read]s diff]5tiate ! p>ties to ! debates4 ,9 ?is pla9-text transcription1 word+ orig9at+ f ph>maceutical s\rces is display$ ) great] ind5tation1 :ile t f m$ical au?orities has less] ind5tation2 h[ev]1 ?is patt]n is n entirely consi/5t4 ,inconsi/5t use ( op5+ & clos+ quotation m>ks is z 9 ! orig9al4 ,!re are num]\s hyph5ation & spell+ inconsi/5cies1 ! mo/ noticeable p]haps be+ ! inclusion or omission ( a f9al #8e' f *emical t]ms su* z oxid_/oxide4 ,^! rema9 z 9 ! orig9al4 ,a repres5tative li/ ( ! inconsi/5cies is app5d$ at ! end ( ! transcription toge!r ) a li/ ( ! spell+ errors t h be5 correct$ sil5tly4 ,inconsi/5t =matt+ ( fractions1 e4g4 #a-d cf4 #a_/d is z 9 ! orig9al4 ,! text conta9s v>i\s words1 phrases & comm5ts enclos$ by squ>e brackets4 ,^! 7 ins]t$ by ! au?ors4 ,a few omissions not$ by ! transcrib] h be5 ins]t$ )9 curly brackets to help diff]5tiate !m - h5ce ( a be 84 ,a miss+ full /op & a miss+ p>5!sis h ea* be5 ins]t$ sil5tly2 r$undant duplicat$ punctuation 74 17 has be5 delet$ sil5tly2 & on page #bii a duplicat$ phrase has be5 delet$ sil5tly1 viz4 ?is dread disease is no long] a matt] ( d\bt4 ,sev]al l>ge l&scape-=mat tables h be5 modifi$ 9 ?is transcription to fit n>r[] view+ scre5s & #8key's add$ to id5tify ! column head+s4 ,a ma!matical error 9 ,table #b on page #cij is z 9 ! orig9al - ,rat #d av]age weight ga9_/loss %\ld be #b4a n #b4g4 ,table #aa on page #ddd conta9s a footnote cross-ref]5ce to ,tables #h & #aj b ^! d n exi/4 ,,! ,,propag&a ,,= ,,re=m --,,9-- ,propriet>y ,m$ic9es ,"p ,i4 ,c\ncil ,reports ,"p ,,ii4 ,laboratory ,contributions ,"p ,,iii4 ,contributions f ! ,j\rnal3 ,no/rums ,"p ,,iv4 ,contributions f ! ,j\rnal3 ,miscellany ,n9? ,edition ,,repr9t$ ,,f ,,! ,,j\rnal ,,( ,,! ,,am]ican ,,m$ical ,,association ,,preface ,f "t to "t ,! ,j\rnal ( ! ,am]ican ,m$ical ,association has publi%$ ! reports ( ! ,c\ncil on ,ph>macy & ,*emi/ry & ! ,*emical ,laboratory1 z well z o!r matt] on propriet>y m$ic9es4 ,repeat$ reque/s = "s ( ! matt] h l$ to ! compilation ( 8,! ,propag&a = ,re=m 9 ,propriet>y ,m$ic9es10 :i*1 9 ! pres5t volume1 atta9s its n9? edition4 ,! sev5?1 eigh? & n9? editions h be5 compil$ on slightly diff]5t pr9ciples f _! pr$ecessors4 ,! !rapeutic re=m "w ( ,! ,j\rnal & ( ! ,association's ,*emical ,laboratory 0 at fir/ conf9$ almo/ entirely to ! criticism & analysis ( ! s-call$ e?ical propriet>ies4 ,?is 0 "r2 ! m$ical pr(ession ow$ x to ! public to combat ! no/rum evil )9 its own ranks4 ,z ! m flagrant evils ( ! 8e?ical propriet>y0 "q 7 mitigat$1 ! ,association has turn$ ! light on ! m widespread & dang]\s 8pat5t m$ic9e0 evil4 ,! articles devot$ to 8pat5t m$ic9es0 or quack]y be+ naturally ( great] int]e/ to ! g5]al public ?an to ! m$ical pr(ession1 ! numb] ( inquiries f laym5 reg>d+ v>i\s quacks & no/rums has /eadily increas$4 ,x has be5 ?\ght be/1 !re=e1 to publi% sep>ately#a all ( ! matt] f ,! ,j\rnal relative to quack]y & to ^? no/rums exploit$ only or *iefly to ! public1 & to include 9 ! ,propag&a = ,re=m practically none ( ! matt] t is ( direct int]e/ prim>ily to laym54 ,9 "o or two in/ances 9 :i* ! subjects 7 ( equal int]e/ to ! pr(ession & to ! public matt] t has already appe>$ 9 8,no/rums & ,quack]y0 is also giv5 "h2 b z a g5]al rule ! cont5ts ( ! n9? edition ( 8,! ,propag&a = ,re=m0 are ( /rictly pr(essional int]e/4 ,^? physicians :o are desir\s ( obta9+ 9 conv5i5t =m ! matt] deal+ ) 8pat5t m$ic9es0 %\ld ord] ! book 8,no/rums & ,quack]y0 or ! v>i\s pamphlets on ! same subjects t h be5 issu$ s9ce 8,no/rums & ,quack]y0 came f ! press4 #a ,?is matt] appe>s 9 8,no/rums & ,quack]y10 a #gjj-page book1 & also 9 v>i\s pamphlets4 ,write = ! descriptive price-li/ ( publications deal+ ) ! no/rum evil4 ,! n9? edition ( 8,propag&a = ,re=m0 conta9s a numb] ( new articles1 greatly increas+ ! size ( ! book4 ,x also conta9s "o novel feature :i* greatly enhances its value4 ,! index includes ref]5ces n only to articles 9 ! book1 b also to matt] on propriet>ies n accept$ by ! ,c\ncil on ,ph>macy & ,*emi/ry :i* appe>$ 9 ,! ,j\rnal ( ! ,am]ican ,m$ical ,association & else:]e4 ,?is index makes ( ?is edition ( 8,propag&a = ,re=m0 a v full "w ( ref]5ce on propriet>ies :i* are undes]v+ ( recognition4 ,x %\ld be und]/ood1 h[ev]1 t n all articles index$ are condemn$2 "s are m]ely discuss$ & comp>$4 ,,table ,,( ,,cont5ts ,,"p ,i3 ,,c\ncil ,,reports ,,page ,acetanilid ,mixtures #i ,ag>-,lac #aj ,anas>c9 & ,an$em9 #aa ,maign5 ,antiseptic ,p[d] #ai ,tyree's ,antiseptic ,p[d] #ba ,ap]gels #bf ,aseptikons #bf ,betul-,ol #bg ,peacock's ,bromides & ,*ionia #bh ,bromidia #ca ,cactus ,gr&iflorus #cf ,calcreose #dj ,campho-,ph5ique #dj ,cel]9a1 ,aletris ,cordial & ,k5n$y's ,p9us ,canad5sis1 ,light & ,d>k #dc ,c9]>ia ,m>itima #di ,hagee's ,cordial ( ! ,extract ( ,cod ,liv] ,oil ,comp\nd #ea ,wampole's ,p]fect$ & ,ta/eless ,prep>ation ( an ,extract ( ,cod ,liv] #eb ,wat]bury's ,metaboliz$ ,cod-,liv] ,oil ,comp\nd #ed ,wat]bury's ,comp\nd #eg ,col*i-,sal #eh ,cypridol ,capsules #ei ,cy/og51 ,cy/og5 ,ap]i5t & ,cy/og5-,li?ia #fj ,cy/o-,s$ative #fa ,taka-,dia/ase & ,liquid ,taka-,dia/ase #fb ,digal5 ,omitt$ f ,n4 ,n4 ,r4 #fh ,diorad9 ,refus$ ,recognition #gc ,e*9acea #gi ,e*tisia1 ,ec?ol & ,e*itone #ha ,ergoapiol #hb ,erpiol 7,dr4 ,s*rad]7 #hc ,false ,unicorn 7,helonias7 #hd ,=murol #he ,ga/rog5 ,tablets #hg ,glyco-,h]o91 ,smi? #hh ,glyco-,?ymol9e #ib ,glycozone #ie ,g>dn]'s ,syrup ( ,hydriodic ,acid #ig ,hyp]ol #ajj ,+luv9 #aja ,inte/9al ,antiseptic ,w-,a #ajc ,bann]man's ,intrav5\s ,solution #aje ,iodalia #ajf ,iodex #ajg ,iodia #ajh ,burnham's ,soluble ,iod9e #aaj ,iodotone #aac ,iosal9e #aac ,n\rry ,w9e #aae ,labord9e #aae ,lactobacill9e ,omitt$ f ,n4 ,n4 ,r4 #abj ,reexam9ation ( ,lactopept9e #aba ,meat & ,beef ,juices #abc ,val5t9e's ,meat ,juice #abi ,m$ic9al ,foods #aca ,migra99 #ace ,neurilla #acf ,neuros9e1 ,dioviburnia1 ,g]miletum & ,palpebr9e #aci ,oxy*lor9e #adg ,pam-,ala1 ,ano!r ,wor?less ,qu99 ,sub/itute #adi ,papayans ,bell #aea ,passiflora & ,daniel's ,conc5trat$ ,t9cture ( ,passiflora #aef ,liquid ,comb9ations ,conta9+ ,peps9 & ,pancreat9 #aeg ,pepto-,mangan 7,gude7 #aei ,liquid ,petrolatum or 8,russian ,m9]al ,oil0 #afa ,cl9ical ,exp]i5ce ) ,liquid ,p>aff9 7,liquid ,petrolatum7 #afg ,angi]'s ,emulsion #afi ,phecolates1 ,phecolax1 ,phecozymes & ,phecotones #agd ,ph5ol ,sodique #age ,phyt9 & ,=tossan #agh ,prunoids #agh ,sal ,hepatica #agi ,sanmetto #ahb ,secretog5 #ahe ,s9k9a #ahh ,somnos #aic ,succus ,alt]ans #aie ,sulpho-,ly?9 #aif ,taurocol #aih ,tri-,iodides1 ,?ree ,*lorides & ,maizo-,li?ium #aih ,?ialion #bje ,ungu5tum ,sel5io ,vanadic 7,v4 ,roem]7 #bjg ,unicorn ,root1 ,wild ,yam & ,wild ,indigo #bjh ,propriet>y ,vanadium ,prep>ations #bji ,v5>s5 #bab ,v5od9e #bad ,v]acolate #baf ,hayd5's ,viburnum ,comp\nd #bah ,v9 ,m>iani #bba ,virol #bbe ,,"p ,,ii3 ,,contributions ,,f ,,! ,,*emical ,,laboratory ,anusol ,hemorrhoidal ,suppositories #bbg ,aromatic ,dige/ive ,tablets #bbi ,burnham's ,soluble ,iod9 #bcc 8,hydrocyanate ( ,iron-,tild50 #bce ,hymosa #bch ,micajah's ,m$icat$ ,ut]9e ,waf]s #bdj ,noitol & ,anadol #bde ,pix ,cresol #bdg ,saliod9 #bdi ,!obrom9 ,sodium ,salicylate ,v]sus 8,diuret902 ,! ,economical ,aspect #bea ,ungu5t9e #bed ,uric$9 #bef ,urisept9 #bef ,zemacol #bei ,zyme-,oid #bfa ,,"p ,,iii3 ,,contributions ,,f ,,! ,,j\rnal3 ,,no/rums ,alleotone #bfd ,baume ,analgsique ,b5gu #bfg ,antidiabeticum-,bau] #bfg ,antikamnia #bfh ,anusol ,suppositories #bhj ,aspiro-,li?9e #bha ,bell-,ans 7,pa-,pay-,ans1 ,bell7 #bhb ,biosol #bhd ,brom9-,iod9 ,comp\nd #bhe ,calm9e #bhf ,camph5ol #bhg ,*olog5 #bhh ,hagee's ,cordial ( ,cod-,liv] ,oil #bhi ,wat]bury's ,comp\nd ,once ,m #bia ,collyrium-,wye? #bib ,diatuss9 #bic ,ent]onol #bid ,expurgo 7,sanol7 ,anti-,diabetes #bii ,=mam9t #cjc ,gom5ol #cjd ,heada*e ,cures #cje ,hect9e #cjh ,hydronaph?ol #cjh ,hydrozone #cji ,hypoqu9idol #caj ,iodonucleoid #caj ,iridium #cab ,iron ,tropon #cac ,kutn['s ,p[d] #cad ,lymph ,comp\nd ,r-,h & ,or*itic ,fluid ,tablets #cag ,lysol--,! ,evolution ( a ,propriet>y #cah ,?ompson's ,malt$ ,food ,company #cai ,manola #cbc ,m]col #cbf ,midol & ,nurito #cbg ,mu-col #cbi ,n>k9e #cbi ,pap9e #ccj ,pasadyne #ccb ,pas-,av5a #ccc ,p]tuss9 #ccd ,ph5alg9--,a ,typical ,example #cce ,ph5o-,bromate #cdc ,ph5olph?ale9 #cdc ,mix$ ,vacc9e & ,phylacog5s #cdf ,! ,dang] 9 ,protonucle91 a ,prep>ation ,conta9+ ,?yroid #cdh ,purg5 #cdi ,pyo-,atox9 #cej ,res9ol #ceb ,resor-,bisnol #cec ,rob9ol & ,sevetol #cec ,salacet9 #cef ,sal-,codeia-,bell #ceg ,sanatog5 #ceh ,sanatog53 a ,sci5tific ,inve/igation ( ,its ,alleg$ ,action on ! ,recup]at+ ,p[]s ( ! ,blood #cgh ,! ,fe$+ ,value ( ,sanatog5 ,comp>$ ) ,comm]cial ,case9 ) ,respect to ,ma9t5ance & ,gr[? #che ,poehl's ,sp]m9 9 ,art]ioscl]osis #cie ,syrup ( ,cocillana ,comp\nd #cif ,aub]gi]'s ,syrup ( ,lactuc>ium #cii ,t>t>li?9e #dja ,?oxos #djb ,trypsog5 #djc ,tyree's ,antiseptic ,p[d] #djd ,vapo-,cresol5e #djh ,vasog5 & ,iodovasog5 #djh ,viburnum ,comp\nd--& o!r ,no/rums #dji ,:eel]'s ,n]ve ,vitaliz] #daa ,zymotoid #dab ,,"p ,,iv3 ,,contributions ,,f ,,! ,,j\rnal3 ,,miscellane\s ,,matt] ,acetph5etid9 & ,ph5acet9--,_! ,relative ,purity #dad ,clean ,adv]tis+ #dah ,lipp9cott's ,magaz9e #dai ,m$ical ,j\rnal ,adv]tis+ #dbb ,m$ical ,j\rnals & ! ,great ,am]ican ,fraud #dbf ,! ,army & ,navy ,m$ical ,record #dcb ,! ,m$ical ,times ,adv]tisem5ts #dch ,cause = ,optimism #ddj ,! ,comp>ative ,nutri5t ,value ( ,cod ,liv] ,oil & ,cod ,liv] ,oil ,cordials #ddb ,diabetic ,foods ,(f]$ = ,sale 9 ! ,unit$ ,/ates #ddf ,! ,jireh ,diabetic ,food ,company #dea ,! ,"n 8,ep9ephr90 ,v]sus ! ,"n 8,adr5al90 #ded ,! ,hord ,sanit>ium #def ,! ,g]man ,propag&a = ,re=m #deh ,! ,g]man ,c\ncil on ,ph>macy & ,*emi/ry #dei ,gr& ,prix & ,gold ,m$als = ,sale #dfb ,! ,hypophosphite ,fallacy #dfd ,buffalo ,li?ia ,wat] #dfg ,meat ,extracts & ,meat ,juices #dgj ,ph>maceutical ,manufactur]s & ! ,great ,am]ican ,fraud #dgd ,d[d's ,phosphatomet] #dgf ,amorph\s ,phosphorus #dgh ,,! ,,propag&a ,,= ,,re=m ,,9 ,,propriet>y ,,m$ic9es ,,"p ,i ,,c\ncil ,,reports ,,acetanilid ,,mixtures,a ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,a ,see also ,labord9e1 p4 #aae2 ,heada*e ,cures1 p4 #cje2 ,anadol1 p4 #bdd2 ,ph5alg91 #cce4 ,to ! ,c\ncil on ,ph>macy & ,*emi/ry3 ,9 response to ! reque/ ( y\r *airman we h inve/igat$ ! bel[-m5tion$ prep>ations & report z foll[s3 ,specim5s ( ! articles 7 b\ght 9 diff]5t cities 9 ! op5 m>ket1 & 9 orig9al seal$ packages1 & 7 analyz$ by "s ( u or "u our direction4 ,ea* article 0 exam9$ by at lea/ two *emi/s1 & "s 7 subject$ to sev]al analyses4 ,:ile c]ta9 ( ! prep>ations are repres5t$ z be+ *emical comp\nds1 ! specim5s exam9$ 7 all f\nd to be mixtures1 ! pr9cipal +r$i5t be+ acetanilid4 ,! p]c5tage proportions ( acetanilid giv5 bel[ are ! m9imum obta9$ by any ( ! analy/s4 ,soda & ammonia1 comb9$ ) c>bonic acid1 are calculat$ & report$ z sodium bic>bonate & z ammonium c>bonate 7,u4 ,s4 ,p47 respectively4 ,salicylic acid is calculat$ & report$ z sodium salicylate4 ,dilu5ts & o!r con/itu5ts ?an ^? report$ 7 n det]m9$4 ,,ammonol ,accord+ to ! analyses ( ! cont5ts ( ! orig9al seal$ packages z pur*as$1 ?is 0 f\nd to be a mixture1 & to conta9 ! foll[+ +r$i5ts approximately 9 ! proportions giv53 ,acetanilid4 ,sodium ,bic>b4 ,ammonium ,c>b4 #ej4 #be4 #bj4 ,,antikamnia,b ,b ,see also ,antikamnia1 ,! ,no/rum & ,its ,me?od ( ,exploitation1 page #bfh4 ,accord+ to ! analyses ( ! cont5ts ( ! orig9al seal$ packages z pur*as$1 ?is 0 f\nd to be a mixture1 & to conta9 ! foll[+ +r$i5ts approximately 9 ! proportions giv53 ,acetanilid ,caffe9 ,citric ,acid ,sodium ,bic>b4 #fh4 #e4 #e4 #bj4 ,,koehl]',s ,,heada*e ,,p[d]s ,accord+ to ! analyses ( ! cont5ts ( ! orig9al seal$ packages z pur*as$1 ?is 0 f\nd to be a mixture1 & to conta9 ! foll[+ +r$i5ts approximately 9 ! proportions giv53 ,acetanilid ,caffe9 #gf4 #bb4 ,,orange9e ,accord+ to ! analyses ( ! cont5ts ( ! orig9al seal$ packages z pur*as$1 ?is 0 f\nd to be a mixture1 & to conta9 ! foll[+ +r$i5ts approximately 9 ! proportions giv53 ,acetanilid ,sodium ,bic>b4 ,caffe9 #dc4 #ah4 #aj4 ,o!r con/itu5ts said to be pres5t 7 n det]m9$4 ,,ph5alg9,c ,c ,see also ,ph5alg9--,a ,typical ,example1 p4 #cce4 ,accord+ to ! analyses ( ! cont5ts ( ! orig9al seal$ packages z pur*as$1 ?is 0 f\nd to be a mixture1 & to conta9 ! foll[+ +r$i5ts approximately 9 ! proportions giv53 ,acetanilid ,sodium ,bic>b4 ,ammonium ,c>b4 #eg4 #bi4 #aj4 ,c]ta9 packages ( ph5alg9 7 pur*as$ :i* on analysis did n %[ ammonium c>bonate4 ,,salacet9,d ,d ,see also ,salacet91 p4 #cef4 ,accord+ to ! analyses ( ! cont5ts ( ! orig9al seal$ packages z pur*as$1 ?is 0 f\nd to be a mixture1 & to conta9 ! foll[+ +r$i5ts approximately 9 ! proportions giv53 ,acetanilid ,sodium ,bic>b4 ,sodium ,salicylate #dc4 #ba4 #bj4 ,we recomm5d t ?is report be pr9t$ 9 ,! ,j\rnal ( ! ,am]ican ,m$ical ,association4 ,respectfully submitt$1 ,j4 ,h4 ,long1 ,m4,s41 ,sc4,d41 ,w4 ,a4 ,puckn]1 ,ph4,g41 ,committee on ,*emi/ry1 ,s4 ,p4 ,sadtl]1 ,ph4,d41 ,c\ncil on ,ph>macy & ,j4 ,/ieglitz1 ,ph4,d41 ,*emi/ry ( ! ,a4 ,m4 ,a4 ,h4 ,w4 ,wiley1 ,m4,d41 ,ph4,d41 7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,june #c1 #aije74 ,,ag>-,,lac ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,ag>-lac1 said to be ! product ( 8,ag>-lac1 ,inc410 is sold by ,e4 ,f\g]a & ,company1 ,new ,york4 ,! foll[+ 8=mula0 = ,ag>-lac is publi%$3 8,ag>-,ag> ) ,lactic ,f]m5ts ,grs4 #d-a_/b ,ph5olph?ale9 ,grs4 #a_/b0 ,reg>d+ ! 8lactic f]m5t10 ! id5tity ( :i* is n decl>$ by ! manufactur] & = ! viability ( :i* no precautions appe> to be tak51 ! ,c\ncil's exp]t on lactic acid f]m5ts report$ t ,bacillus bulg>icus 0 pres5t 9 small numb]s only & t !re 7 at lea/ two o!r bact]ia pres5t1 "o ( :i* is a gas-=m] ( ! ,bacillus coli type4 ,! ,c\ncil f\nd t ! am\nt ( ag>-ag> 9 ,ag>-lac & ! id5tity ( ! 8lactic f]m5t0 are n decl>$2 t ! "n 8,ag>-lac0 is bl[n 9 ! glass & t ! me?od ( its exploitation w lead laym5 to use x to _! detrim5t2 t ! claims t x 8facilitates assimilation ( proteids0 & t x is ( value z an aid to 8ga/ro-inte/9al dige/ion0 give a false value to ! mixture & t ! claims emphasize ! action ( ag>-ag> :5 f ! composition x is evid5t t ! ph5olph?ale9 action w pr$om9ate2 t ! "n does n indicate its pr$om9at+ con/itu5t1 ph5olph?ale91 & t ! use ( a ready-made comb9ation ( ca?>tic drugs1 su* z ag>-ag> & ph5olph?ale9 ) lactic acid f]m5ts1 is unsci5tific4 ,! ,c\ncil !re=e refus$ recognition to ,ag>-lac4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #ad1 #aiad47 ,,anas>c9 ,,& ,,an$em9 ,reports ( ! ,c\ncil on ,ph>macy & ,*emi/ry & ,comm5ts ,!reon ,! foll[+ reports 7 submitt$ to ! ,c\ncil by ! subcommittee to :i* ^! articles 7 assign$3 ,,anas>c9 ,to ! ,c\ncil on ,ph>macy & ,*emi/ry3--,y\r subcommittee to :om ,anas>c9 7,anas>c9 ,*emical ,co41 ,w9*e/]1 ,t5n47 0 assign$1 h]e) submits its report3 ,?is rem$y is (f]$ 9 two =ms3 8,anas>c9 ,tablets10 a pret5d$ comb9ation ( ! active pr9ciples ( oxyd5dron arboreum1 sambucus canad5sis1 & urg9ea scilla2 & 8,anas>c9 ,elixir10 said to conta9 ! active pr9ciples ( oxyd5dron1 sambucus1 hepatica & potassium nitrate4 ,! adv]tisem5ts ( ^! articles conflict ) ! rules ( ! ,c\ncil z foll[s3 ,) ,rules #a & #b3 ,! composition ( ^! articles is kept secret1 9 t ! proportion ( ! +r$i5ts is n furni%$4 ,! /atem5t t x conta9s ! 8active pr9ciples0 is mislead+1 s9ce ^! are = ! mo/ "p unkn[n4 ,) ,rule #f3 ,! description ( ! ph>macologic action ( ,anas>c9 agrees practically ) t ( squill4 ,no mat]ial "p ( its effects c be attribut$ to ! o!r +r$i5ts4 ,nev]!less1 ! adv]tisem5t /udi\sly cultivates ! impression t ,anas>c9 has no relation :atev] to ! digitalis gr\p 9 :i* scilla is commonly plac$4 ,! claims are !re=e mislead+4 ,! claim ( its inf9ite sup]iority to digitalis1 ! claims t x cures neura/h5ia1 elim9ates uric acid 9 rheumatism1 & is useful 9 obesity1 cy/itis1 lumbago & eclampsia1 dyspepsia & a/hma1 & t x works wond]s 9 exoph?almic goit]1 appe> exagg]at$ or false4 ,! recomm5dation ( its indiscrim9ate use 9 nephritis1 = l[]+ ! blood-pressure & ! /atem5t 7contradict$ 9 ! firm's own lit]ature7 t x is n depress+1 are actually dang]\s4 ,x is recomm5d$ t ! articles be refus$ recognition1 & t ! report1 ) explanations1 be publi%$4 ,,an$em9 ,to ! ,c\ncil3--,y\r subcommittee to :om ,an$em9 7,an$em9 ,*emical ,co41 ,w9*e/]1 ,t5n47 0 assign$ h]e) submits its report3 ,an$em9 is an evid5t imitation ( ,anas>c94 ,x is m>ket$ z tablets1 said to conta9 ! isolat$ active pr9ciples ( /rophan?us1 apocynum1 squill & sambucus1 *emically comb9$4 ,! quantities are n /at$4 ,! !rapeutic claims are copi$ almo/ lit]ally f ! ,anas>c9 circul>s & are equally false4 ,an$em91 !re=e1 conflicts ) ,rules #a1 #e1 #f & #g4 ,x is recomm5d$ t ?is report be publi%$1 ) comm5ts4 ,! reports 7 adopt$ by ! ,c\ncil & are h]e) publi%$4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,anas>c9 ,?is wond]ful rem$y1 ,anas>c91 has already be5 expos$ 9 ^! columns 7,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #bg1 #aijf71 b x des]ves additional m5tion1 z x tea*es sev]al important lessons ( g5]al application4 ,x is a typical example ( ! revival1 "u a new "n & a ?9 disguise1 ( an old1 "t-worn article1 squill1 presumably because exp]i5ce has demon/rat$ its g5]al inf]iority to o!r drugs4 ,anas>c9 fur!r illu/rates ! dang]s involv$ 9 ! use ( semi-secret no/rums4 ,x also %[s h[ a %ort exp]i5ce ) a widely adv]tis$ b little und]/ood drug is apt to lead to conclusions :i* m ext5sive exp]i5ce demon/rates to be entirely fallaci\s4 ,! fir/ lesson is1 t =mulas are n always :at !y seem4 ,a ha/y glance at ! =mula ( ,anas>c9 tablets1 ! basis ( ! ,anas>c9 dropsy cure1 creates ! impression t x is a non-secret rem$y2 = x is said to repres5t a comb9ation ( ! active pr9ciples ( oxyd5dron1 sambucus & scilla4 ,z a matt] ( fact1 x is a secret no/rum ( ! insidi\s k9d4 ,a =mula :i* omits ! quantities ( its pot5t +r$i5ts means v little4 ,fur!r ?an ?is1 we d n hesitate to *>ge t ! claim$ composition is a delib]ate deception4 ,! circul>s emphasize ! claim t ,anas>c9 consi/s ( ! isolat$ pr9ciples1 & n ( ! crude drugs4 ,n[1 ! isolat$ active pr9ciples ( sambucus & oxyd5dron are n on ! m>ket1 = ! good & suffici5t reason t no active pr9ciples h ev] be5 isolat$4 ,are we to believe t ! ,anas>c9 ,company has surpass$ ! accr$it$ *emi/s & has discov]$ su* pr9ciples & is isolat+ !m8 ,we %all h m to say on ?is subject pres5tly2 b any "o 9 ! lea/ famili> ) ! difficulties att5d+ ! isolation ( organic pr9ciples kn[s su* an idea to be prepo/]\s4 ,inde$1 x is absolutely incompatible ) ! exhibition ( ignorance ( ! elem5t>y facts ( ph>maceutical *emi/ry :i* is giv5 by ^! p :5 !y call ! active pr9ciples ( digitalis & squill 8alkaloids40 ,x is an axiom t ! effects ( a mixture c only be und]/ood if ! action ( its compon5ts are kn[n4 ,s f> z we "k1 ! physiologic effects ( oxyd5dron & sambucus h nev] be5 sci5tifically inve/igat$1 = ! simple reason t !y are too slight & indef9ite to promise results4 ,bo? are cr$it$ ) "s slight1 obscure diuretic action4 ,oxyd5dron1 ! s\r wood or sorrel tree1 is a small tree ( ! hea? family1 ! acid leaves ( :i* are said to be *ew$ by hunt]s = _! pleasant ta/e & = ! relief ( ?ir/4 ,sambucus is ! common eld]4 ,x is mo/ unlikely t ^! two innocu\s sub/ances %\ld play any "p 9 ! claim$ p[]ful effect ( ,anas>c92 !y are evid5tly put 9 ! =mula1 we d n say 9 ! prep>ation1 to obscure ! fact t ,anas>c9 is compos$ pr9cipally ( squill4 ,t ?is is s c be ga!r$ unmi/akably f a /udy ( ! ph>macologic action ( ,anas>c9 z describ$ by its promot]s3 ,act+ prim>ily on ! he>t & art]ial sy/ems ?r\gh ! n]ve ganglia1 a natural physiologic balance is e/abli%$ betwe5 ! art]ial & v5\s sy/ems1 :]eby effusions 444 are elim9at$4444 ,co9cid5t ) ?is action !re is a notewor?y sl[+ ( ! pulse4444 ,if ! rem$y is pu%$1 c be br\ght d[n to #bj or #cj beats p] m9ute4444 ,its physiological action is to /imulate ! c>diac motor-ganglia ?r\gh ! c>diac plexus ( ! sympa!tic sy/em & at ! same "t ex]t an inhibitory influ5ce ^u ! c>diac fib]s ( ! pneumoga/ric1 !reby dilat+ ! art]ioles1 sl[+ ! he>t's action1 & increas+ ! =ce ( ! sy/ole4444 ,! prolong$ dia/ole all[s ! v5tricle "t to completely fill1 & ! m =cible contraction causes ! mitral valve to close m ?or\ghly & at ! same "t increases pressure 9 ! coron>y art]ies1 s]v+ !reby ! d\ble purpose ( reliev+ pulmon>y engorgem5t & increas+ he>t nutrition4 ,anas>c9 w nauseate "s p]sons4 ,to appreciate fully ! mean+ ( ?is description ( ! actions ( ,anas>c91 x %\ld be comp>$ ) ! effects ( ! digitalis gr\p1 to :i* squill belongs4 ,! foll[+ acc\nt is quot$ lit]ally f a rec5t text-book ( ph>macology 7,sollmann73 ,! ph5om5a ( ! !rapeutic /age ( digitalis action are said to be3 #a4 ,sl[+ ( ! he>t1 ) sy/ole & dia/ole bo? l5g!n$4 #b4 ,increas$ /r5g? ( beat1 lead+ to great] effici5cy ( ! individual contractions1 & to an increase 9 ! total effici5cy4 #c4 ,a t5d5cy to ! sy/olic phase4 #d4 ,a rise ( blood-pressure1 due ma9ly to ! increas$ action ( ! he>t1 b p>tly also to a vasocon/riction4 ,! !rapeutic action may be expla9$1 9 "p1 z foll[s3 ,a l>g] am\nt ( blood w be ?r[n into ! aorta & coron>y circulation4 ,! fir/ effect w be an improv$ nutrition ( ! he>t4444 ,! tonic action 444 n>r[s ! r+ ( ! valves1 br+s !m toge!r1 n>r[s ! orifice4444 ,! v5\s conge/ion w t5d to be reliev$4 ,?is relief 444 w fall 9 ! fir/ place on ! lungs4444 ,! l[]+ ( ! v5\s pressure w t5d to cause absorption ( ! effusions4 ,! nauseant action ( squill1 :i* is allud$ to 9 connection ) ,anas>c91 is too well kn[n to require m ?an a m5tion4 ,9 brief1 !n1 x appe>s f ! /atem5ts ( ! ,anas>c9 ,company t ! action ( ! rem$y is t ( squill & t ! o!r +r$i5ts are a m]e bl9d4 ,x is1 ( c\rse1 well kn[n t squill c be us$ z a sub/itute = digitalis 9 c>diac dropsy1 al?\gh x is g5]ally consid]$ v inf]ior to ! latt] drug4 ,rose ,brad=d1 = in/ance1 /ates3 8,squill is n us$ to any ext5t 9 ! treatm5t ( c>diac disease & c>diac dropsy1 digitalis be+ a f> m effici5t & less toxic sub/ance40 ,h[ev]1 x has be5 frequ5tly obs]v$ t digitalis occasionally fails1 & x may !n be replac$ successfully by ano!r memb] ( ! gr\p4 ,at all ev5ts1 x is v likely t squill is a fairly effici5t sub/itute = digitalis1 especially :5 x is supplem5t$ by a v free c\rse ( ,epsom salts & by potassium nitrate 7! active +r$i5t ( ,anas>c9 ,elixir71 bo? ( :i* are /at$ to be ess5tial adjuvants to ! ,anas>c9 7or squill7 tablets4 ,!re c be no objection to ! use ( squill :5 x is indicat$2 b any "o :o wi%es to use x %\ld d s ) 8 eyes op51 kn[+ :at sub/ance he is us+ & h[ mu* 7:i* he does n 9 ,anas>c972 kn[+ also t x has ! same indications & limitations z digitalis4 ,he %\ld n be misl$ by su* /atem5ts z ! foll[+3 8,does :at dropsy m$icam5ts h hi!rto fail$ to accompli%40 8,sup]ior to digitalis1 /rophan?us1 scop>ius1 squills1 acetate ( pota% & ! hydragogue ca?>tics all put toge!r40 8,! only kn[n relief h[ mode/6 & p]man5t cure ( dropsies40 8,unrival$ he>t tonic40 8,! mo/ p[]ful ag5t kn[n40 ,any "o wi%+ to use squill %\ld take ! tr\ble to acqua9t himself ) ! results obta9$ by compet5t & indep5d5t obs]v]s1 & n rely on x 9 eclampsia1 septicemia1 8vices ( civilization10 all =ms ( neura/h5ia1 z 8an active elim9ator ( uric acid 9 rheumatism10 9 hepatic cirrhosis1 dyspepsia1 a/hma1 obesity1 cy/itis 7671 lumbago1 exoph?almic goit]1 etc4 ,he %\ld also le>n ! contra-indications to ! use ( squill1 d$ucible f ! fact t x causes vasocon/riction & raises ! blood-pressure 7prohibit+ its use 9 ,bright's disease & art]ioscl]osis71 & t x produces m>k$ ga/ric irritation1 consequ5tly nausea & depression1 t x is a v toxic ag5t1 & t ! dang]s ( cumulative action mu/ be borne 9 m9d4 ,9 respect to ^! ! adv]tisem5ts ( ! ,anas>c9 p are little %ort ( crim9al1 = ^! /ate3 8,safe 9 adm9i/ration40 8,non-toxic z ord9>ily adm9i/]$40 8,w nauseate "s p]sons10 b 8! reaction f ! tempor>y depression is prompt40 8,9 ,bright's disease1 bo? ! int]/itial & p>5*ymat\s =ms ( nephritis1 acute or *ronic1 no rem$y 444 to equal x 9 efficacy40 8,)\t increas+ ! debility ( ! pati5t or int]f]+ ) nutrition by produc+ loss ( appetite44440 8,?is treatm5t is to be cont9u$ )\t cessation until all symptoms ( dropsy h disappe>$40 ,physicians :o are incl9$ to disreg>d ?is w>n+1 & :o foll[ ! advice ( ! ,anas>c9 p1 %\ld rememb] t _! pati5ts--or _! fri5ds--w put ! blame = ! results1 :i* are b\nd to foll[ soon] or lat]1 on ! prescrib]s1 & n on ! deceptive adv]tisem5ts ( ! ,anas>c9 ,*emical ,company4 ,!re is ano!r little matt] :i* ?r[s an illum9at+ side-light on ! ,anas>c9 ,company4 ,!y take e occasion to say t ,anas>c9 is 8n (f]$ to ! laity10 8nev] sold to ! laity10 etc42 b witness ! foll[+1 :i* 0 f\nd 9 ! ,retail ,druggi/ ( ,may1 #aijf1 p4 #agi4 ,! italics are ours4 ,,cure ,,= ,,dropsy4 8,z e druggi/ kn[s1 dropsy has be5 "o ( ! incurable diseases :5 caus$ ei!r f he>t1 liv] or kidney tr\ble4 ,a ph>maci/ 9 ,w9*e/]1 ,t5n41 has work$ out a rem$y call$ ,anas>c91 :i* he is exploit+ to ! physicians1 & 8 rem$y is %[+ itself z possess+ great m]it4 ,sev]al hopeless cases h be5 treat$ z a la/ resort by ,anas>c9 & 9 a v %ort "t ! pati5t has %[n m>k$ improvem5t & has effect$ p]man5t cures4 8,! result ( ! cases z h&l$ by ! physician ) ! aid ( ,anas>c9 has be5 s easily & quickly cur$ t physicians ( ,t5nessee & ! s\!rn /ates are high 9 _! praises ( ! rem$y4 ,! company :i* n[ manufactures & sells x is kn[n z ! ,anas>c9 ,*emical ,co41 ( ,w9*e/]1 ,t5n4 ,any druggi/ :o kn[s ( a case ( dropsy w\ld be conf]r+ a favor on ! pati5t & mank9d 9 g5]al by tell+ ! p>ty or 8 physician ( ! s\!rn ph>maci/1 & we h no d\bt b :at a prompt relief & p]man5t cure w\ld be affect$40 ,probably means effect$4--,ed4 ,an$em9 ,if we are dispos$ to d\bt ! vaunt$ sci5tific ability ( ! ,anas>c9 ,company1 we are =c$ to admire _! bus9ess me?ods1 at lea/1 if !re is any tru? 9 ! say+ t imitation is ! seal ( success4 ,anas>c9 has _h ?is r undesirable complim5t paid to x1 = its native t[n ( ,w9*e/] has giv5 bir? to ano!r rem$y1 ,an$em91 :i* looks l a fair-hair$ tw9 bro!r4 ,! ,an$em9 ,company has adopt$ ,anas>c9 almo/ bodily4 ,! "n--8oppos$ to edema0--is ab\t z close z ! copyright laws p]mit4 ,! ph>macologic & !rapeutic claims agree almo/ lit]ally ) ^? ( ,anas>c9 & conta9 ! same exagg]ations & dang]\s mis/atem5ts4 ,!re is ! same emphasis on free purgation ) ,epsom salts4 ,! dose is ! same4 ,bo? are m>ket$ at #b4jj = a box ( #ajj--only ! ,an$em9 p h adopt$ ! prize package device ( ?r[+ 9 #bj or #cj tablets extra1 = good measure1 & give a disc\nt ( #ge c5ts or s4 ,illu/ration3 ,laboratory & ,w>eh\se ( ! ,anas>c9 ,*emical ,company1 ,w9*e/]1 ,t5n4 ,9 %ort1 ! ,an$em9 ,company has appropriat$ all ( ,anas>c9 :i* !y consid]$ ( any value4 ,x is1 !re=e1 r sugge/ive t !y drew ! l9e at ! =mula4 ,anas>c9 is said to conta9 squill1 sambucus & oxyd5dron2 ,an$em9 disc>ds ! oxyd5dron & re9=ces ! squill ) /rophan?us & apocynum4 ,not)/&+ ?is mat]ial *ange 9 composition1 ! actions are describ$ z id5tical2 ?is is aga9 r sugge/ive4 ,! ,an$em9 ,company1 l ! ,anas>c9 ,company1 scorns crude drugs & claims to use only ! isolat$ pr9ciples4 ,x 0 sav$ ! tr\ble ( discov]+ active pr9ciples = /rophan?us & apocynum1 = ^! are kn[n2 b x manag$ to f9d "s scope = its inv5tive g5ius1 8bo? drugs be+ s *emically treat$ & dispos$ z to absolutely elim9ate all objectionable & disagreeable prop]ties & effects0 s z to conv]t a vasocon/rictor action into a dilator action2 s z to r5d] !m non-toxic & non-cumulative2 s z to deprive apocynum ( its *>act]i/ic nauseant effect4 ,:o c say t ! days ( miracles are pa/8 ,ev5 ?is is n ! limit ( ,an$em9 al*emy2 if we are to believe _! claims1 !y h succe$$ 9 =c+ /rophan?91 apocynum1 scilla91 etc41 to comb9e ) ea* o!r3 8,x is a def9ite *emical comp\nd ( ! active pr9ciples0 ( ^! drugs6 ,?is makes ! a*ievem5ts ( ,emil ,fis*] 9 syn!siz+ sug>s & proteids appe> z m]e *ild's play4 ,s9ce ! =mulas 7 complet$1 h[ev]1 cl9ical reports h be5 num]\s en\gh--almo/ too num]\s1 if we are to believe !m4 ,an$em9 has be5 on ! m>ket = less ?an ?ree ye>s2 ! circul>s emphasize t te/imonials & endorsem5ts are n solicit$4 ,nev]!less1 we are told t x is 8endors$ by ov] fifty ?\s& cl9icians ?r\gh\t ! ,unit$ ,/ates40 ,s9ce ! total numb] ( physicians 9 ! ,unit$ ,/ates & ,canada is only ab\t #abh1jjj1 ?is means t ne>ly e second physician has endors$ ,an$em94 ,! ,anas>c9 ,company solicits endorsem5ts & !y seem to d ! l>g] bus9ess4 ,h5ce ! majority ( physicians ( ! ,unit$ ,/ates mu/ h writt5 an endorsem5t ( ei!r ,an$em9 or ,anas>c91 or bo?4 ,or is ?is /atem5t ano!r 8inv5tion08 ,x is a little peculi> t ne>ly all ! endorsem5ts come f small t[ns 9 sp>sely settl$ di/ricts2 practically none f ! c5t]s ( population4 ,does ?is mean t dropsy is m common 9 ! rural communities ?an 9 ! cities8 ,,! ,,inv5tors ,,( ,,anas>c9 ,,& ,,an$em9 ,ev5 ! newspap]s1 :5 !y tax our cr$ulity ) pret5d$ sci5tific 8discov]ies10 feel ! moral obligation ( ju/ify+ !mselves by tell+ u some?+ ( ! p]sonality & exp]i5ce ( ! discov]]s4 ,we may ask1 !re=e1 :o are ^! exp]t ph>maceutic & syn!tic *emi/s1 ^! manufactur]s ( active pr9ciples1 ^! skill$ cl9icians ( wide exp]i5ce1 :o h 8intellig5tly built up ! =mula by wide application08 ,:at are we told ( ^! m5 :o ask u to believe1 on _! m]e assurance1 9 miracles & feats ( magic2 :o tell u t !y h conv]t$ neutral pr9ciples into alkaloids1 t !y h effect$ def9ite *emical comp\nds betwe5 ^! neutral pr9ciples1 t !y h discov]$ pr9ciples t d n exi/1 t !y h *ang$ ! actions ( ^! pr9ciples to suit _! wi%es1 t1 9 %ort1 !y h rev]s$ ! laws ( ,nature8 ,^! companies are locat$ 9 ,w9*e/]1 ,t5n41 a t[n ( ab\t #a1ejj inhabitants1 situat$ 9 an agricultural c\ntry4 ,! t[n boa/s ( nei!r sci5tific s*ools1 colleges1 univ]sities nor laboratories4 ,! ,anas>c9 ,company 0 organiz$ 9 #aijb1 ! incorporators & directors be+ ,dr4 ,john ,w4 ,gris>d & 8 sons1 ,dr4 ,john ,p4 ,gris>d1 ,b4 ,a4 ,gris>d1 & ,a4 ,f4 ,gris>d1 & ,w ,e4 ,walk]1 all ( ,w9*e/]4 ,dr4 ,john ,w4 ,gris>d seems to be ! orig9ator & promot] ( ,anas>c94 ,w4 ,e4 ,walk] is an insurance solicitor ( ,w9*e/] & is n actively id5tifi$ ) ! bus9ess4 ,we are in=m$ t he owns b a s+le %>e ( /ock hav+ a face value ( #ajj1 & t he 0 add$ to ! company 9 ord] to comply ) ! laws ( ,t5nessee1 :i* require five directors = any corporation4 ,dr4 ,john ,w4 ,gris>d1 ! fa!r1 has practically retir$1 b /ill has a g5]al sup]vis+ int]e/ 9 ! bus9ess4 ,!re is no regul>ly lic5s$ ph>maci/ or *emi/ connect$ ) ! company4 ,! (fice is 9 ! re> ( a jewelry /ore 9 ! bus9ess "p ( ,w9*e/] & on ! second floor above4 ,accord+ to our report]1 an (fice =ce ( ab\t t5 /5ograph]s & cl]ks h&les ! correspond5ce & labels & s5ds out ! prep>ation :i* is made 9 a crude frame build+ locat$ on a side /reet & )\t laboratory equipm5t4 ,accord+ to our report]1 ! "w is done by ! ,gris>ds & a color$ man4 ,! ,an$em9 ,*emical ,company 0 organiz$ 9 #aije ) a capital ( #bj1jjj1 ! incorporators & directors be+ ,dr4 ,t4 ,b4 ,&]ton1 ,floyd ,e/ill1 ,j4 ,j4 ,lyn*1 ,j4 ,m4 ,littleton & ,i4 ,g4 ,phillips1 all resid5ts ( ,w9*e/]1 & all lawy]s ) ! exception ( ,dr4 ,t4 ,b4 ,&]ton4 ,a ,mr4 ,gordon1 a cl]ical employee ( ! company1 is report$ to h active *>ge ( ! bus9ess1 to prep>e ! m$ic9e & conduct ! correspond5ce4 ,! (fice headqu>t]s1 laboratory & complete outfit ( ! ,an$em9 ,company comprises two rooms ov] ! law (fice ( ,e/ill ,littleton4 ,no "o connect$ ) ! company is a regul>ly lic5s$ ph>maci/ or graduate *emi/4 ,( ! six physicians locat$ 9 ,w9*e/]1 ?ree 7#ej p] c5t47 are engag$ 9 ! dropsical cure bus9ess4 ,poor ,w9*e/]6 ,aside f _! connection ) ^! two no/rums1 ^! physicians may be e/imable & wor?y citiz5s1 b :]e1 pray1 did !y f9d ! ext5sive cl9ical facilities & ph>maceutical k necess>y = _! wond]ful & epo*-mak+ discov]y8 ,7 !y aid$ 9 _! sci5tific "w by ! f\r lawy]s connect$ ) ! ,an$em9 ,company or by ! insurance solicitor :o is a director ( ! ,anas>c9 ,company8 ,did ! #a1ejj inhabitants ( ! t[n furni% ! va/ cl9ical mat]ial necess>y = discov]+ & work+ out ! =mulas ( ^! two prep>ations8 ,if s1 we fe> t dropsical affections are mu* m preval5t 9 ,w9*e/] ?an 9 any o!r kn[n spot on ! globe4 ,?is matt] %\ld be inve/igat$4 ,)\t d\bt ! vital /ati/ics ( ,frankl9 ,c\nty w\ld be mo/ int]e/+ & we comm5d !m to ! special att5tion ( ! m$ical pr(ession 9 ,t5nessee4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,may #d & #aa1 #aijg47 ,,maign5 ,,antiseptic ,,p[d] ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! report :i* appe>s bel[ 0 submitt$ by a ref]ee & aft] adoption by ! ,c\ncil 0 s5t to ! manufactur] = comm5t1 9 accordance ) ! ,c\ncil's regul> proc$ure 9 su* cases4 ,! manufactur]'s comm5ts 7 transmitt$ to a second ref]ee1 :o report$ t aft] a c>eful consid]ation ( ! manufactur]'s reply he saw no valid reason = a modification ( ! report4 ,! ref]ee also report$ t a visit to ! ,maign5 ,in/itute fur!r s]v$ to conv9ce him ( ! vici\sness ( ! treatm5t z giv5 & t ! records made by ! p]sons 9 ! employ ( ! in/itute 7 too inadequate to s]ve z cl9ical evid5ce4 ,on ! ref]ee's recomm5dation1 ! report z orig9ally adopt$ 0 re5dors$ by ! ,c\ncil & au?oriz$ = publication4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,maign5 ,antiseptic ,p[d] is m>ket$ by ! 8,maign5 ,in/itute = ! ,/udy ( ,bact]ial ,diseases10 ,philadelphia4 ,x is claim$ to be a mixture ( calcium hydroxid1 sodium c>bonate1 alum9um sulphate & boric acid1 b no /atem5t z to ! am\nt ( ! sev]al con/itu5ts is furni%$4 ,its action dep5ds on ! sodium hydroxid :i* is =m$ :5 ! p[d] is treat$ ) wat]1 #a ,gm4 ( ! p[d] z n[ submitt$ to ! ,c\ncil yield+ #j4cb ,gm4 ( sodium hydroxid 7,na,o,h7 & a specim5 obta9$ a ye> ago yield+ #j4bh ,gm4 ,its promiscu\s use is recomm5d$ bo? to physicians & to ! public ) claims :i* are extravagant1 prepo/]\s & ev5 dang]\s4 ,a pamphlet1 cle>ly int5d$ = ! laity1 entitl$ 8,:at ,is ,cat>rh80 gives direction = ! 8/]ilization0 ( ! nose1 ?roat1 /oma*1 lungs1 eyes1 gums1 m\? & ! g5ito-ur9>y tract4 ,! foll[+1 tak5 f ?is pamphlet1 illu/rates ! absurdity ( ! claims made = ,maign5 ,antiseptic ,p[d]3 8,,/]ilization ,,( ,,! ,,/oma* 8,,take ( ! ,maign5 ,antiseptic ,p[d] half ! quantity rais$ on a dime1 scant4 8,,add to a tumbl] ( wat]1 pref]ably w>m1 & /ir4 8,,dr9k ,,sl[ly4 8,,?is ,,is ,,:at ,,may ,,happ53 8#a74 ,bel*+ may be ! fir/ indication ( ! /]ilization ( ! /oma*4 8#b74 ,! excess ( acidity is correct$4 8#c74 ,! f]m5tation is /opp$4 8#d74 ,! /]ilization ext5ds to ! ,inte/9al ,tract4 8#e74 ,! b[els are regulat$ )\t purgation4 8#f74 ,! :ole metabolic process is improv$4 8,,:5 ,,& ,,h[ ,,(t5 ,,to ,,dr9k ,,! ,,antiseptic ,,solution4 8a74 ,= ,indige/ion1 :5ev] di/ress$1 be=e or aft] meals4 8b74 ,= ,con/ipation1 half an h\r be=e breakfa/ or la/ ?+ at night4 8c74 ,= ,ga/ro-,inte/9al tr\bles1 su* z ,typhoid ,fev]1 ,dys5t]y & ,*ol]a1 :i* are ! mo/ s]i\s =ms ( cat>rhal inflammation1 take half a tumbl] or a :ole tumbl] ( hot wat] ) half ! quantity ( ,p[d] rais$ on a dime e h\r1 & betwe5 times a glass ( g5]\s sic w9e4 8,,rem>ks 8,! /]ilization recomm5d$ "h is a pla9 dis9fect+ process :i* does n int]f]e ) m$ical treatm5t4 ,x is1 on ! contr>y1 ( great assi/ance to x4 8,x has be5 f\nd v effective 9 break+ up ! cig>ette habit4 ,x does away ) ! crav+ by remov+ ! morbid irritation ( ! muc\s membrane40 ,eighty-eight disord]s are li/$ 9 a pamphlet entitl$ 8,antiseptic ,!rapeutics0 all ( :i* are report$ z hav+ be5 treat$ ) success4 ,! dang]\s "* ( ! ,maign5 8/]ilization0 propag&a is illu/rat$ by a pamphlet 8,fir/ ,aid to ,baby-,sick0 & by ! recomm5dation on ! trade package3 8,to prev5t ,blood ,poison+1 ,lockjaw1 ,hydrophobia & ,infecti\s ,diseases40 ,! leg5d on ! trade package & ! adv]tis+ matt] conta9$ 9 x are likely to lead ! public to place dep5d5ce on a weak sodium hydroxid solution z a means ( prev5t+ blood-poison1 lockjaw1 hydrophobia & infecti\s diseases4 ,! pamphlet 8,fir/ ,aid to ,baby-,sick0 recomm5ds its use 9 sore eyes1 tee?+ & sore m\?1 sore ?roat1 runn+ e>s1 runn+ nose1 sore *e/1 summ] compla9t1 sk9 tr\bles & infection aft] vacc9ation2 if any tru/ is put 9 ^! claims1 !y are b\nd to lead to ! sacrifice ( _m infants ?r\gh neglect ( prop] treatm5t4 ,pat5t ,no4 #a1jhf1cci has be5 grant$ on ?is p[d] to ,p4 ,j4 ,a4 ,maign5 ( ,philadelphia by ! ,u4 ,s4 pat5t (fice on ! foll[+ specification ( claim made 9 ! application3 8#a4 ,a process = de/roy+ microorganisms on liv+ tissue1 )\t injur+ ! latt] 444 :]eby ! gr[? ( su* organisms is inhibit$ & _! sub/ance dissolv$ )\t delet]i\s effect ^u contigu\s heal?y tissue40 ,) braz5 assurance ?is grant has be5 twi/$ by ! unscrupul\s promot]s into a gov]nm5t endorsem5t ( ! prep>ation4 ,x1 ( c\rse1 means no?+ ( ! sort1 z1 no d\bt1 9 accordance ) legal r\t9e ! pat5t 0 grant$ )\t any inve/igation by ! pat5t (fice to det]m9e ! effectiv5ess ( ! p[d] = ! purpose claim$4 ,9 view ( ! dang]\s1 unw>rant$ & absurd claims made = ,maign5 ,antiseptic ,p[d] ! ref]ee recomm5ds t x be refus$ recognition1 & t ! ,c\ncil decl>e its agreem5t ) views express$ 9 ! article 8,maign5 ,pulv40 publi%$ 9 ,! ,j\rnal1 ,feb4 #ae1 #aiac1 p4 #ecg1 p>ticul>ly ! foll[+3 8,! g]micidal p[]s ( /rong alkalies h long be5 kn[n1 b ! inconv5i5ce ( _! application to tissues & muc\s membranes has prev5t$ _! use4 ,t !y w be ( s]vice :5 suffici5tly dilut$ n to irritate ! tissues is improbable1 = ! antiseptic p[] ( su* solution is slight & ! dis9fectant value practically nil40 ,because ! ,maign5 ,in/itute has twi/$ ! grant+ ( ,u4 ,s4 pat5t ,no4 #a1jhf1cci into a quasi-endorsem5t ( ! claims made = ,maign5 ,antiseptic ,p[d] x is recomm5d$ t a copy ( ?is report be s5t to ! ,commission] ( ,pat5ts z a prote/ aga9/ ! pres5t law1 :i* au?orizes ! grant+ ( pat5ts on unprov$ & improbable m$ical claims4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #ad1 #aiad47 ,,tyree',s ,,antiseptic ,,p[d],e ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ) ,comm5ts ,e ,see also ,tyree's ,antiseptic ,p[d]1 p4 #djd4 ,tyree's antiseptic p[d] 0 assign$ = exam9ation to a subcommittee ( ! ,c\ncil1 :i* made ! foll[+ report3 ,to ! ,c\ncil on ,ph>macy & ,*emi/ry3--,y\r subcommittee1 to :om 0 assign$ ,tyree's ,pulv4 ,antiseptic ,comp41 m>ket$ by ,j4 ,s4 ,tyree1 ,wa%+ton1 ,d4 ,c41 reports z foll[s3 ,! label on ! package /ates3 8,?is prep>ation is a sci5tific comb9ation ( borate ( sodium1 alum51 c>bolic acid1 glyc]9 & ! cry/alliz$ pr9ciples ( ?yme1 eucalyptus1 gaul!ria & m5?a1 9 ! =m ( a p[d]10 etc4 ,! /atem5t t ! p[d] conta9s ! cry/all9e pr9ciples ( ?yme1 eucalyptus1 gaul!ria & m5?a is vague & mislead+1 s9ce ! *ief m$ical con/itu5ts ( eucalyptus & gaul!ria are liquids1 b x t5ds to convey ! impression t ! p[d] conta9s ! ess5tial con/itu5ts ( ^! drugs1 namely1 ?ymol1 oil ( eucalyptus or eucalyptol1 oil ( w9t]gre51 or me?yl salicylate1 & m5?ol4 ,! lit]ature suppli$ to physicians claims its composition to be3 8,p>ts1 sod4 bor41 #ej2 alum51 #ej2 ac4 c>bol41 #e2 glyc]91 #e2 ! cry/4 pr9ciples ( ?yme1 #e2 eucalyptus1 #e2 gaul!ria1 #e1 & m5?a1 #e40 ,! composition1 !re=e1 might be express$ z foll[s3 ,sodium borate 7borax7 #ej p>ts1 or #ch4df p] c5t4 ,alum #ej p>ts1 or #ch4df p] c5t4 ,ph5ol 7c>bolic acid7 #e p>ts1 or #c4he p] c5t4 ,glyc]9 #e p>ts1 or #c4he p] c5t4 ,?ymol #e p>ts1 or #c4he p] c5t4 ,oil ( eucalyptus or eucalyptol #e p>ts1 or #c4he p] c5t4 ,oil ( gaul!ria 7or me?yl salicylate7 #e p>ts1 or #c4he p] c5t4 ,m5?ol #e p>ts1 or #c4he p] c5t4 ,analysis ( specim5s pur*as$ f diff]5t s\rces 9 ! op5 m>ket 7 made "u our direction4 ,! reports ( ! *emi/s %[ t ,tyree's antiseptic p[d] conta9s no borax1 or m]e traces only1 & t x conta9s no alum1 or m]e traces only4 ,in/ead1 ! analyses %[ t boric acid & z9c sulphate are ! ess5tial con/itu5ts4 ,! am\nts ( c>bolic acid1 ?ymol1 m5?ol1 etc41 conta9$ 9 ! p[d]1 if pres5t1 7 f> bel[ ! quantities indicat$ by ! =mula4 ,! pres5ce ( glyc]9 c\ld n be demon/rat$1 &1 if pres5t1 ! am\nt mu/ be v small4 ,"o *emi/ reports3 ,! result ( analysis %[s t diff]5t samples diff] slightly 9 composition1 b t ! foll[+ indicates ! av]age composition ( ! product3 ,p] ,c5t4 ,z9c sulphate1 anhydr\s #ae4ef ,boric acid #ha4bf ,volatile matt] at #ajj ,c4 = f\r h\rs #j4de ,! undet]m9$ portion consi/s ( salicylic acid1 c>bolic acid1 m5?ol & eucalyptol2 possibly o!r antiseptic ag5ts may be pres5t 9 v m9ute quantities4 ,f ! above f9d+s we conclude t ,tyree's antiseptic p[d] is a mixture ( boric acid & dri$ z9c sulphate & antiseptic bodies1 su* z m5?ol1 salicylic acid & c>bolic acid1 eucalyptol1 etc4 ,f ?is x c be readily se5 t ! label1 :i* is suppos$ to set =? ! composition ( ,tyree's antiseptic p[d]1 is n 9 accord ) ! facts4 ,! p[d] does n conta9 ei!r borate ( sodium or alum1 & ! pres5ce ( glyc]9 c\ld n be e/abli%$4 ,! antiseptic ag5ts1 exclusive ( ! boric acid1 are pres5t only 9 small am\nts4 ,! report ( ano!r analysis concludes z foll[s3 ,x evid5tly conta9s less ?an ! am\nt /at$ ( ! pr9ciples ( ?yme1 eucalyptus1 w9t]gre5 & m9t4 ,x also conta9s a v small am\nt inde$ ( c>bolic acid1 mu* less ?an t /at$4 ,we h be5 unable to id5tify c]ta9ly ! pres5ce ( glyc]91 & x is d\btful if x be pres5t4 ,f ! result ( ! analysis we feel confid5t t ! prep>ation is to all int5ts & purposes a mixture ( boric acid & sulphate ( z9c4 ,! c>bolic acid1 ?yme1 eucalyptus1 w9t]gre51 etc41 if pres5t1 are pres5t only 9 suffici5t am\nt to give ! comp\nd a satisfactory odor4 ,9 view ( ! fact t ,j4 ,s4 ,tyree has giv5 wide publicity to a =mula :i* ! prec$+ report has %[n to be a delib]ate misrepres5tation ( facts1 x is recomm5d$ t ! article be refus$ recognition by ! ,c\ncil on ,ph>macy & ,*emi/ry1 & t ?is report be publi%$ 9 ,! ,j\rnal ( ! ,am]ican ,m$ical ,association4 ,! recomm5dation ( ! subcommittee 0 adopt$ by ! ,c\ncil 9 accordance ) :i* ! report is publi%$4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,mr4 ,tyree1 9 a lett] to ,dr4 ,simmons 7:i* he /ates he writes at ! reque/ ( ,dr4 ,kebl] ( ! ,drug ,laboratory ( ! ,dep>tm5t ( ,agriculture1 ?\gh he is "u no moral or f9ancial obligation to d s71 says t x has be5 8 int5tion to in=m ! m$ical pr(ession ( 8 reasons = *ang+ ! =mula ( ,tyree's ,antiseptic ,p[d] f an alum & borax base to a boracic acid & z9c base4 ,he /ates t ?is *ange 0 made at ! sugge/ion ( prom95t physicians connect$ ) hospital cl9ics on nose & ?roat1 v5]eal & o!r conditions & t he has _h 9 contemplation ! omission f ! label ( ! v>i\s conditions to :i* ! prep>ation is applicable4 ,mr4 ,tyree1 x w be se51 assumes ! "r to sell to physicians a prep>ation ) a descriptive =mula :i* he ackn[l$ges is false1 & he presumes to use 8 own pleasure z to ! "t :5 he w in=m !m ( its true composition4 ,mr4 ,tyree does n /ate :5 he *ang$ ! =mula4 ,we d n "k :e!r x 0 a ye> ago1 five ye>s ago or t5 ye>s ago1 b we d "k t ! package :i* 0 us$ 9 mak+ ! fir/ analysis 0 pur*as$ z e>ly z la/ ,febru>y1 & ! fir/ *emi/'s report 0 submitt$ to ! ,c\ncil ,m>* #e1 #aijf4 ,on ,april #d ,mr4 ,tyree 0 notifi$ by ! ,c\ncil t ! composition ( ,tyree's ,antiseptic ,p[d] did n correspond to ! =mula publi%$ by him4 ,:e!r or n ,mr4 ,tyree is ju/ifi$ 9 (f]+ our pr(ession a prep>ation z compos$ *iefly ( borax & alum :5 9 reality x is *iefly compos$ ( boric acid & z9c sulphate1 we leave physicians to judge4 ,discrepancies ,betwe5 ,facts & ,claims--,un=tunate ,attempts ( ,mr4 ,tyree at ,explanation ,a report f ! ,c\ncil on ,ph>macy & ,*emi/ry on ,tyree's ,antiseptic ,p[d] appe>$ 9 ,! ,j\rnal1 ,oct4 #bj1 #aijf4 ,?is %[$ t ! prep>ation1 adv]tis$ z a 8sci5tific comb9ation ( borate ( sodium1 alum51 c>bolic acid1 glyc]9 & ! cry/alliz$ pr9ciples ( ?yme1 eucalyptus1 gaul!ria & m5?a1 9 ! =m ( a p[d]40 0 ess5tially a mixture ( boric acid & sulphate ( z9c--approximately f\r-fif?s ( ! =m] to "o-fif? ( ! latt]4 8,! c>bolic acid1 ?yme1 eucalyptus1 w9t]gre51 etc41 if pres5t1 are pres5t only 9 suffici5t am\nt to give ! comp\nd a satisfactory odor40 ,z w be rememb]$1 9 ! correspond5ce publi%$ at t "t1 ,mr4 ,tyree attempt$ to expla9 ! discrepancies betwe5 8 /atem5ts & ! prov$ facts by intimat+ t he _h rec5tly *ang$ ! =mula1 & t x 0 8 int5tion 8on or ab\t ! fir/ ( ,febru>y to /ate to ! m$ical pr(ession 8 reasons = *ang+ ! =mula10 & t ! *ange _h be5 made 8a %ort "t ago1 at ! sugge/ion ( sev]al prom95t g5tlem540 ,s9ce t "t1 ?r\gh circul>s & o!r adv]tisem5ts1 ,mr4 ,tyree has attempt$ to expla9 ! matt] 9 v>i\s ways4 ,9 8 late/ circul> lett] he seems to make a delib]ate attempt to mislead our pr(ession & to misrepres5t facts to a degree t makes x almo/ impossible to believe t ! circul> came f a man :o claims to be honorable4 ,fir/1 h[ev]1 we %all take ?is opportunity to publi% "s matt] :i* we h _h 9 res]ve s9ce ! fir/ expos 0 made la/ ,octob]4 ,:5 x 0 realiz$ t ,mr4 ,tyree int5d$ to def5d himself by claim+ t a *ange _h rec5tly be5 made 9 ! p[d]1 we took occasion to try to secure "s ( ! prep>ation t _h be5 on ! m>ket = a long "t4 ,9 ?is we succe$$ v well4 ,f a ,*icago druggi/ "o package 0 b\ght :i* _h be5 9 ! /ore at lea/ s9ce ,july1 #aijb--;h[ mu* long] is n kn[n4 ,! druggi/ f :om ! p[d] 0 obta9$ b\ght ! drug /ore 9 ,july1 #aijb1 & ?is p[d] 0 on h& at t "t1 none hav+ be5 b\ght s9ce4 ,?is p>ticul> p[d] 0 analyz$ by a *emi/1 :o f\nd ! composition practically ! same z t giv5 9 ! ,c\ncil's report1 ?is *emi/ e/imat+ t x conta9$ approximately #ha p] c5t4 boric acid & #ad p] c5t4 anhydr\s z9c sulphate4 ,be>+ 9 m9d t = at lea/ f\r ye>s & t5 mon?s ,tyree's ,p[d] has be5 ess5tially ! same z x is today1 ?is lett] is v int]e/+3 7,! comm5ts 9 brackets are1 ( c\rse1 ours47 8,j4 ,s4 ,,tyree1 8,*emi/1 8,,wa%+ton1 ,d4 ,c4 8,april #af1 #aijg4 8,dr4 --------1 8----1 8,my ,de> ,sir3--,doctors & m$ical publications ( extreme & prejudicial m9ds (t5 hold & express op9ions 9 honorable fai?1 b l all critics1 !y are n always famili> ) ! conditions compos+ _! op9ions1 & are (t5 giv5 to express+ !m )\t k ( ! true motives & facts 9 ! case4 8,if y w read an article t appe>$ 9 "o ( ! m$ical weeklies "s "t ago ,! ,j\rnal ( ! ,am]ican ,m$ical ,association1 ( c\rse & :i* has be5 copi$ by sev]al ( its (fspr+s n _m we regret to say relat+ to ,tyree's ,antiseptic ,p[d]1 y w see t ,i _h previ\sly in=m$ ! editor z well z 8 c\ncil ( inve/igators1 t at ! sugge/ion ( prom95t physicians1 ext5sive cl9ical exp]im5t+ sic 7 be+ made ) "s slight 6 6 6 *anges 9 my p[d]1 ! object be+ to develop & ext5d its usefulness 9 new l9es ,x _h already be5 recomm5d$ = ab\t ev]y?+#b & at ! same "t make x m acceptable to ! g5]al run ( ! pr(ession4 ,i also notifi$ ?is editor t ^! inve/igations w\ld n be complet$ until ! fir/ ( ! pres5t ye>1 aft] :i* "t ^! slight 6 6 6 *anges 9 ! =mula ( ,tyree's ,p[d] w\ld be ann\nc$4 ,x is n[ ! middle ( ,may2 :5 & :]e 7 ! *anges ann\nc$8#c #b ,f ! circul> accompany+ a package b\ght ov] a ye> ago1 we f9d ! p[d] recomm5d$ = ! foll[+ conditions3 8,= ,leucorrhea1 ,gonorrhea1 ,vag9itis1 ,pruritus1 ,ulc]at$ conditions ( ! mucus membrane4444 ,scr(ul\s1 ,syphilitic & ,v>icose ,ulc]s 444 = ,spray+ ! ,nose & ,?roat1 444 = imm$iate deodoriz+ & dis9fect+ 444 = prickly heat1 poison oak1 squam\s eczema & o!r conditions ( simil> nature4444 ,z a deodorant & prophylactic 9 d5tal "w1 444 = dis9fect+ (f5sive cavities 444 = pr(use & (f5sive p]spiration1 swell+1 sor5ess & burn+ ( ! body & feet4444 ,z a delightful toilet prep>ation aft] ! ba? & %av+40 #c ,la/ ,janu>y ! national ,food & ,drugs ,act w5t into effect2 "o ( its provisions is t ! label mu/ n lie4 ,?is is n ! exact v]biage1 b x means ! same ?+4 ,s1 in/ead ( repeat+ ! old false /atem5ts1 ! new label ( ,tyree's antiseptic p[d] conta9s no?+ :atev] ab\t ! composition2 ! law does n require t x %\ld--unless ! prep>ation conta9s c]ta9 specifi$ drugs4 ,:y is ! =mula omitt$8 8,!re is no?+ new1 />tl+ or dang]\s 9 su* *anges 9 =mulas4 ,! ,ph>macopeias & national books ( au?ority are cont9u\sly improv+ _! =mulas4 ,x is ! same ) e prep>ation on ! m>ket4 ,mr4 ,tyree1 z a no/rum mak]1 is 9 a position to "k4 ,8 plea evid5tly is3 8,i am no worse ?an o!rs40 ,! app>5t difficulty 9 my case is caus$ by my exceptional frankness 8exceptional frankness0 is good "u ! circum/ances ) ! pr(ession 9 tell+ !m :5 & :]e8 ab\t ?is improvem5t be=e ,i 0 ready to ann\nce full details & p>ticul>s1 or place my improv$ sic p[d] on ! m>ket4 8,y\rs v truly1 8,j4 ,s4 ,tyree40 ,= ye>s ,mr4 ,tyree has be5 mislead+ physicians by mak+ false /atem5ts reg>d+ ! composition ( 8 p[d] & reg>d+ its value z a !rapeutic ag5t4 ,:5 expos$ he tries to def5d himself & 8 bus9ess by /atem5ts & excuses t are wor?y ( a s*oolboy try+ to get out ( a bad scrape4 ,we w\ld respectfully sugge/ to him t he ei!r take 8 wond]ful p[d] (f ! m>ket1 or--:i* w\ld probably am\nt to ! same ?+--tell ! tru?1 & ! :ole tru?1 ab\t x4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,may #ah1 #aijg47 ,,ap]gols,f ,ab/ract ( ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,f ,= ab/ract ( report on ,ergoapiol see p4 #hb2 = ! unabridg$ report ( ! ,c\ncil's action on ,ap]gols1 see ,reports ,c\ncil ,ph>m4 & ,*em41 #aiad1 p4 #fd4 ,ap]gols1 put out by ,h4 ,k4 ,wampole ,co41 ,inc41 is alleg$ to be a 8,ut]9e ,/imulant40 ,ap]gols is app>5tly an inv]sion ( ! "n ,ergoapiol & ! prep>ation appe>s to h ess5tially ! same =mula1 namely3 ,apiol #e m94 ,oil ,sav9e #a_/b m94 ,ergot9 #a gr4 ,alo9 #a_/h gr4 ,aromatics q4 s4 ,z 9 ,ergoapiol1 ! con/itu5t ref]r$ to 9 ! =mula z 8,apiol0 appe>s to be oleores9 ( p>sley-se$ in/ead ( ! def9ite sub/ance apiol describ$ 9 ,new & ,non(ficial ,rem$ies4 ,9 g5]al ! claims made = ,ap]gols are ! same z ^? made = ,ergoapiol 7see p4 #hb74 ,! ,c\ncil refus$ admission to ,ap]gols because !y are adv]tis$ indirectly to ! public1 because ( unw>rant$ !rapeutic claims1 because ( ! non-descriptive "n & because ! product is unsci5tific4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,dec4 #ab1 #aiad47 ,,aseptikons ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,aseptikons are vag9al suppositories sold by ! ,*9osol ,co4 ( ,new ,york4 ,ea* suppository is said to conta93 ,ac4 ,salicylici #b gr4 ,ac4 ,borici #aj gr4 ,qu94 purae 7,alkal47 #a gr4 ,*9osol #b gr4 ,b4 ,cacao #fj gr4 ,! foll[+ claims appe> 9 adv]tisem5ts3 8,^! suppositories are indicat$ 9 c]vicitis1 leucorrhea1 specific & non-specific vulvo-vag9itis & 9 all cases :]e complete vag9al antisepsis is desir$40 8,non ,toxic1 ,non ,irritat+2 ,no ,damage to ,membranes4 ,yet a ,m ,p[]ful ,antiseptic ?an ,bi*loride40 ,! ,c\ncil decid$ t ! =ego+ claims 9 ! abs5ce ( evid5ce mu/ be held exagg]at$ & likely to mislead1 & also t ! claim 8,/rong] ?an ,bi*loride0 :i* appe>s on ! box is mislead+4 ,! position ( ! ,c\ncil is t 8,9 ! case ( ph>maceutical prep>ations or mixtures ! trade "n mu/ be s fram$ z to indicate ! mo/ pot5t +r$i5ts40 ,! "n ,aseptikons does n give any indication ( ! +r$i5ts ( ! product4 ,! ,c\ncil holds t 8,! comb9ation ( two or m rem$ies 9 a mixture mu/ be consid]$ contr>y to sci5tific m$ic9e unless a di/9ct reason exi/s = su* comb9ation40 ,no evid5ce has be5 submitt$ to e/abli% ! value ( ! comb9ation 9 ,aseptikons4 ,on ! basis ( ! evid5ce submitt$ ! ,c\ncil vot$ t ,aseptikons be refus$ recognition because unw>rant$ & mislead+ !rapeutic claims are made1 because ! "n does n indicate its pot5t con/itu5ts1 & because ! comb9ation ( two or m rem$ies 9 a mixture is consid]$ contr>y to sci5tific m$ic9e unless a di/9ct reason exi/s = su* comb9ation4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #ad1 #aiad47 ,,betul-,,ol,g ,ab/ract ( ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,g ,= ! unabridg$ report ( ! ,c\ncil's action on ,betul-ol1 see ,reports ,c\ncil ,ph>m4 & ,*em41 #aiad1 p4 #fb4 ,betul-ol 7,e4 ,f\g]a & ,co41 ,new ,york7 is a me?yl salicylate prep>ation adv]tis$ to physicians 7& indirectly to ! public7 z an ext]nal analgesic & anti-rheumatic4 ,! /atem5ts reg>d+ its composition are vague1 mislead+ &1 z %[n by exam9ation 9 ! ,*emical ,laboratory ( ! ,am]ican ,m$ical ,association1 untrue4 ,! !rapeutic claims are bas$ on disc>d$ !ories4 ,al?\gh ! alleg$ sup]iority ( natural ov] syn!tic salicylates has be5 disprov$1 physicians are urg$ to use ,betul-ol because x conta9s1 or is alleg$ to conta91 a natural salicylate4 ,ano!r disc>d$ !ory is press$ into s]vice 9 ! claim t ! *loral 9 ! mixture w be absorb$ & conv]t$ into *lor(orm 9 ! blood4 ,! recomm5dations = ! use ( ,betul-ol 9 rheumatism are likely to lead ! public to ! self-treatm5t ( rheumatism4 ,9 view ( ! s]i\s complications & sequelae ( rheumatic fev] ?is recomm5dation is utt]ly unju/ifiable & a dang] to public heal?--ev5 if ! ext]nal application ( ?is mixture 9 unc]ta9 doses 7 z effective z a prop] int]nal use ( salicylates--a !ory contr>y to exp]i5ce & unsupport$ by adequate evid5ce4 ,! ,c\ncil !re=e refus$ recognition to ,betul-ol4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,dec4 #ab1 #aiad47 ,,peacock',s ,,bromides ,,& ,,*ionia ,reports ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has au?oriz$ publication ( ! foll[+ reports on ,peacock's ,bromides & ,*ionia1 sold by ! ,peacock ,*emical ,company1 ,/4 ,l\is4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,,peacock',s ,,bromides ,?is is ano!r no/rum ( ! ord9>y mixture type4 ,( ! v>i\s /atem5ts conc]n+ composition furni%$ by ! company1 ! foll[+ gives z mu* in=mation z any3 8,9 ,peacock's ,bromides x is design$ to unite fifte5 gra9s ( ! pure/ bromides ( ,potassium1 ,sodium1 ,ammonium1 ,calcium & ,li?ium1 9 su* proportion z to insure ! brom9e equival5t ( potassium bromide4 ,ea* fluid dra*m ab\t equals1 9 m$ic9al /r5g?1 fifte5 gra9s ( potassium bromide40 ,! label on ! trade package indicates ! pres5ce ( #aj p] c5t4 ( alcohol4 ,x w be obs]v$ t ! proportions ( ! diff]5t bromids are n /at$4 ,h5ce1 ! ass]tion ( ! ,peacock ,*emical ,company t 8!re is no?+ secret 9 ?is comp\nd0 _c be true4 ,a physician prescrib+ x _c "k h[ mu* ( ea* +r$i5t he is giv+2 x may be #ad-a_/b gra9s ( potassium bromid & #a_/h gra9 ea* ( sodium1 ammonium1 calcium & li?ium bromid1 or any o!r ( an enorm\s numb] ( possible p]mutations ( ! proportions4 ,:ile ! !oretical basis ( bromid m$ication is n yet fully settl$1 ! weight ( ! be/ ph>macologic au?ority & cl9ical exp]i5ce is decid$ly aga9/ ! dogmatic claim ( ! ,peacock ,*emical ,company t 8! be/ result is obta9$ by prescrib+ a comb9ation ( bromides40 ,& if !re 7 any advantage 9 prescrib+ su* a comb9ation1 ! physician ought to regulate ! proportions4 ,! foll[+ quotations are f ! adv]tis+ matt]3 8,be+ uni=m 9 purity & !rapeutic p[]1 x c be reli$ ^u to produce cl9ical results :i* x is believ$ _c be obta9$ f ! use ( comm]cial bromide sub/itutes40 8,! purity1 quality & con/ant uni=mity ( ?is high grade product h long made x a /&>d bromide prep>ation40 ,^! claims are unf\nd$4 ,! analyses publi%$ 9 ! conc]n's own adv]tis+ 8lit]ature0 %[ a v>iation ( #h p] c5t41 9 ! bromid cont5t1 :i* c]ta9ly indicates a suffici5t lack ( uni=mity4 ,aga9 quot+3 8,9 ord] to insure ! be/ results ! bromides mu/ be pure1 i4 e41 free f alkalies & almo/ free f *lorides4 ,! ,u4 ,s4 ,p4 all[s ?ree p] c5t4 ( *lorides4 ,peacock's ,bromides conta9s ! lea/ possible am\nt ( ?is impurity4 ,bromism is !re=e less frequ5t 9 ^? cases 9 :i* ?is prep>ation is employ$40 ,9 view ( ! claim ( l[ *lorid cont5t1 x is int]e/+ to note t ! analyses above ref]r$ to %[ t ! *lorid cont5t is actually high] ?an t ( "s o!r bromid prep>ations on ! m>ket4 ,! claim ( m]it on ! gr\nd ( fre$om f *lorids is1 ( c\rse1 absurd1 & mu/ be reg>d$ z an attempt to play ^u ! cr$ulity ( ! doctor4 ,z a matt] ( fact1 ! av]age individual takes ) 8 food _m times ! am\nt ( *lorid he c\ld possibly take 9 contam9at$ bromid4 ,! #aj p] c5t4 ( alcohol w\ld und\bt$ly h a great] di/urb+ influ5ce on ! bromid action ?an ! am\nt ( *lorid t might be pres5t 9 any bromid on ! m>ket4 ,!n we h ! /atem5t t1 ow+ to ?is fre$om f *lorids3 8,bromism is !re=e less 9 ^? cases 9 :i* ! prep>ation is employ$40 ,sodium *lorid1 ev5 z an impurity1 w\ld ret>d r ?an favor ! developm5t ( bromism2 sodium *lorid is ev5 us$ z an antidote 9 bromid poison+4 ,! !rapeutic claims lay /ress on ! value ( ! bromids 9 sleeplessness1 epilepsy1 sexual excitem5t1 tetanus1 infantile convulsions1 *orea1 delirium trem5s1 ! climact]ic1 migra9e1 heada*e due to pelvic conditions1 ov>ian neuralgia1 etc4 ,^! & o!r claims1 :ile too vague to be br&$ z falsehoods1 are mislead+ & n 9 accordance ) mod]n tea*+ or practice2 ! latt] recognize ! limitations ( bromid !rapy z well z its scope & advantages4 ,= in/ance1 9 epilepsy ! company ass]ts t3 8,l>ge doses mu/ be giv5 if we expect to control ! convulsions4 ,we are to be guid$ by ! frequ5cy & ! sev]ity ( ! seizures1 ! saturation ( ! sy/em by bromides & by ! age ( ! pati5t4 ,! rule is #8l>ge doses = long p]iods b ) occasional p]iodic mon?ly or qu>t]ly omissions4' ,:5 we h succe$$ 9 controll+ ! convulsions 9 s f> z greatly dim9i%+ ! frequ5cy & sev]ity ( ! attacks we may !n attempt to decrease ! dose1 b ! results mu/ be c>efully wat*$4 ,increase 9 frequ5cy ( convulsive seizures is a sign t ! bromides mu/ aga9 be pu%$ z be=e40 ,! be/ mod]n cl9ical tea*+ conc]n+ ! treatm5t ( epilepsy is t bromids %\ld be avoid$ except z a la/ resort4 ,bromids d n cure1 & ! am\nt necess>y to control ! convulsions may produce a degree ( m5tal hebetude t is a great] evil ?an ! disease itself4 ,x is recomm5d$ t ! prep>ation be held ineligible = admission to ,n4 ,n4 ,r41 because ( its conflict ) ,rules #a1 #d1 #f & #aj ( ! ,c\ncil1 & t ?is report be publi%$4 ,,*ionia ,*ionia1 accord+ to ! /atem5t ( ! ,peacock ,*emical ,company1 :i* exploits ! product1 conta9s #ai p] c5t4 alcohol & is 8,a ,prep>ation ( ,*ionan?us ,virg9ica40#d #d ,( ,*ionan?us ,virg9ica or fr+e-tree1 ! ,c\ncil on ,ph>macy & ,*emi/ry 9 its #aiab report on 8,"s ,unimportant ,drugs0 said3 8,! drug is mu* us$ by eclectics & homeopa?i/s1 especially z a depurant 9 hepatic & syphilitic disord]s4444 ,! claims = ?is rem$y are n support$ by exp]im5tal evid5ce & cl9ical reports ( its use fail to %[ indications ( discrim9at+ critical obs]vation4 ,x is n notic$ by mo/ ph>macologic au?orities40 ,?is prep>ation is adv]tis$ p>ticul>ly z 8a pot5t hepatic /imulant0 & special claims are made = x 9 v>i\s di/urbances ( ! liv]3 8,*ionia is v well adapt$ 9 ! treatm5t ( hepatic conge/ion ow+ to its specific action 9 deplet+ ! portal circulation40 ,9 passive conge/ion ( ! liv]1 ! manufactur]s w\ld h u believe 8444 we h a drug 9 ,*ionia t w /imulate ! circulation ( ! blood & lymphatics ( ! liv] z well z /imulate its physiological activities & in/ead ( ! pati5t vomit+ ! blood an int]nal depletion ( ! liv] occurs40 8444 9 cases ( simple jaundice due to circulatory 7conge/ive7 *anges 9 ! liv]1 ,*ionia is ! drug #8p> excell5ce' t w rapidly cause a disappe>ance ( ?is symptom40 ,z a prophylactic aga9/ eclampsia1 if a hi/ory ( torpidity ( ! liv] is obta9$3 8,,*ionia %\ld be us$ dur+ ! major portion ( *ild-be>+ p]iod because x acts directly on ! liv] /imulat+ its functional activity40 ,*ionan?us virg9ica has nev] be5 %[n to h ! slighte/ ph>macologic activity & no evid5ce is pres5t$ t its (fspr+1 ,*ionia1 has any !rapeutic value :atev] 9 any di/urbance ( ! liv]4 ,! promot]s !mselves indicate a lack ( fai? 9 _! own prep>ation1 = !y advise ! use ( old & effici5t =ms ( treatm5t along ) ,*ionia--he>t tonics & laxatives 9 passive conge/ion ( ! liv]1 m]curial purge or podophyll9 & sodium phosphate 9 8bili\sness10 & qu99 9 mal>ia4 ,f9ally1 ) delightful ,engli% & elaborate ins\ciance1 !y advise 9 ! treatm5t ( eclampsia3 8,9 all cases ! ut]us %\ld be empti$ z quick z possible4 7,v]sion ( ,cs>ian ,section470 ,! physician :o prescribes ,*ionia promotes a fraud4 ,! ,c\ncil held ,*ionia ineligible = admission to ,n4 ,n4 ,r4 ,editorial ,comm5t3 ,9 ,peacock's ,bromides & ,*ionia ! ,peacock ,*emical ,company has1 = a ?ird ( a c5tury1 be5 foi/+ on ! m$ical pr(ession no/rums compos$ ( drugs t are easily comb9$ 9 any proportion t ! physician may want to prescribe4 ,! company has be5 inflict+ on ! un?9k+ physician pseudo-sci5tific rubbi% 9 ! =m ( adv]tis+ lit]ature t %\ld long ago h be5 reg>d$ z an insult to ! intellig5ce ( ! m$ical pr(ession4 ,! foll[+ m$ical j\rnals are c>ry+ adv]tisem5ts ( ,peacock's ,bromides & ,*ionia3 ,ali5i/ & ,neurologi/ ,am]ican ,j\rnal ( ,surg]y ,am]ican ,m$ic9e ,ar*ives ( ,p$iatrics ,atlanta ,j\rnal-,record ( ,m$ic9e ,buffalo ,m$ical ,j\rnal ,*>lotte ,m$ical ,j\rnal ,*icago ,m$ical ,record] ,d5v] ,m$ical ,times & ,utah ,m$ical ,j\rnal ,eclectic ,m$ical ,j\rnal ,ell+wood's ,!rapeuti/ ,indianapolis ,m$ical ,j\rnal ,int]national ,j\rnal ( ,surg]y ,lancet-,cl9ic ,l\isville ,mon?ly ,j\rnal ( ,m$ic9e & ,surg]y ,m>yl& ,m$ical ,j\rnal ,m$ical ,brief ,m$ical ,=tnightly ,m$ical ,h]ald ,m$ical ,record ,m$ical ,review ( ,reviews ,m$ical ,s5t9el ,m$ical ,/&>d ,m$ical ,summ>y ,m$ical ,times ,m$ical ,_w ,na%ville ,j\rnal ( ,m$ic9e & ,surg]y ,new ,orleans ,m$ical & ,surgical ,j\rnal ,new ,york ,m$ical ,j\rnal ,pacific ,m$ical ,j\rnal ,s\!rn ,practition] ,texas ,m$ical ,j\rnal ,texas ,m$ical ,news ,!rapeutic ,gazette ,wiscons9 ,m$ical ,record] ,woman's ,m$ical ,j\rnal --7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,april #c1 #aiae47 ,,bromidia ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! foll[+ report 0 submitt$ to ! ,c\ncil by a memb] ( its ,committee on ,!rapeutics1 ) ! recomm5dation t publication be au?oriz$4 ,?is recomm5dation 0 adopt$4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,bromidia 7,battle ,co41 ,/4 ,l\is7 at once sugge/s bromids2 yet ,bromidia is ess5tially a *loral r ?an a bromid prep>ation4 ,?is no/rum illu/rates ! ne$ ( ! provision 9 ! ,c\ncil's ,rule #h "u :i* recognition is refus$ ph>maceutical mixtures ^: names d n indicate _! mo/ pot5t +r$i5ts4 ,:ile ! *loral cont5t ( ,bromidia has be5 giv5 consid]able publicity1 yet ! prep>ation is us$ bo? by physicians & by ! public )\t due consid]ation ( its pot5t +r$i5t4 ,?is fact is atte/$ n only by ! fatal results :i* h foll[$ its use b also by ! _m reports ( habit =mation4 ,z long ago z 9 #ahhg a fatal case ( poison+ 0 report$#e to ! m$ical society ( ! ,di/rict ( ,columbia due to an ov]dose tak5 by a ,bromidia addict4 ,! physician :o report$ ?is case also gave 8 exp]i5ce ) ano!r pati5t :o _h ! ,bromidia habit4 ,9 ! discussion ( ! pap] a numb] ( cases 7 report$ by o!rs pres5t 9 :i* ,bromidia _h be5 tak5 )\t a physician's advice & ) m or less grave symptoms ( poison+4 #e ,! ,j\rnal ,a4 ,m4 ,a41 ,july #i1 #ahhg1 p4 #ee4 ,9 ! report ( a dea? ( "o :o _h be5 a slave to ,bromidia x 0 said3#f 8,:5 ! body 0 f\nd1 !re 7 elev5 "o-ounce ,bromidia bottles ab\t ! room or on 8 p]son4 ,n9e 7 entirely empty & ! o!r two 7 ab\t half full4 ,none ( ^! bottles indicat$ t !y _h be5 pur*as$ on a physician's prescription1 only ! druggi/'s label m>k$ #8,bromidia' be+ on !m40 #f ,! ,j\rnal ,a4 ,m4 ,a41 ,april #ba1 #aijf1 p4 #abbj4 ,dr4 ,horatio ,c4 ,wood1 ,jr41 gave#g a /rik+ illu/ration ( h[ prep>ations l ,bromidia come to be us$ ev5 by physicians )\t consid]ation ( _! con/itu5ts3 #g ,! ,j\rnal ,a4 ,m4 ,a41 ,april #ba1 #aijf1 p4 #abbj4 8,)9 an h\r aft] 8 fa!r1 a ,brooklyn physician1 _h giv5 him a dose ( bromid1 ,h4,g4,p41 a prodigal son1 di$ ye/]day at 8 fa!r's home 9 ,brooklyn4 ,two ye>s ago1 :5 he appe>$ to h s[n 8 wild oats1 ! fa!r made him sup]9t5d5t ( 8 c\ntry place1 ne> ,grants ,mills1 ,delaw>e ,c\nty4 ,a week ago ! son left 8 place1 & at #a o'clock ye/]day morn+ appe>$ at 8 fa!r's ,brooklyn home4 ,he 0 n]v\s1 & at #i a4 m4 begg$ = a s$ative4 8#8,i prescrib$ ! usual quantity ( bromidia1' ! "y man's fa!r told a report]4 #8,he 0 weak & _h suff]$ f weak he>t & kidney tr\ble = "s "t4' 8,an h\r lat] ! fa!r f\nd ! son dy+ & adm9i/]$ re/oratives1 b to no avail40 ,a circul>1 8,! ,advantages ( ,bromidia10 makes x pla9 h[ physicians come to use a prep>ation l ,bromidia )\t consid]ation ( its pot5t con/itu5t4 ,9 ?is circul> ! pres5ce ( *loral is at fir/ frankly admitt$1 !n x is sugge/$ t 9 ! comb9ation ! evil effects ( *loral are completely elim9at$ & 9 ! end ! impression is left t ,bromidia is practically innocu\s4 ,?us at ! beg9n+ :ile argu+ t ,bromidia is bett] ?an extemporane\s prep>ations ! *loral cont5t is pla9ly ackn[l$g$3 8,9 ! unt[>d effects s frequ5tly att5d+ ! use ( extemporane\sly prep>$ mixtures ( *loral & ! bromides1 may be f\nd ! reason = ,,bromidia',s pref]5ce :5 ! ne$ = a hypnotic ag5t arises4 ,7 x n = ! well kn[n disadvantages ( ^! drugs :i* become /ill m m>k$ ) _! cont9u$ use1 !re c\ld be no special ne$ = su* a prep>ation z ,,bromidia 7,battle71 = ! !rapeutic p[]s ( *loral & ! bromides are among ! mo/ positive facts 9 m$ic9e40 ,aga93 8,x 0 to meet ! gr[+ pr(essional dem& = a comb9ation ( *loral & ! bromides ) _! evil effects elim9at$1 t l$ to ! manufacture ( ,,bromidia 7,battle740 ,!n1 sugge/+ ! indiscrim9ate use ( ,bromidia--z an entity z ,dr4 ,wood sugge/s--! claim is made t3 8444 its con/itu5ts h be5 *os5 ) a view ( enabl+ ,bromidia to meet e requirem5t = an ag5t ( its class40 8,ow+ to ! exceptional purity ( its compon5t p>ts & its fre$om f unt[>d effects :5 cont9u$ ov] long p]iods1 ?is product w be f\nd ( ! highe/ utility 9 epilepsy40 8444 its action is t ( *loral & ! bromides m9us _! evil effects40 ,f9ally ,bromidia becomes a simple bromid prep>ation4 ,?us an adv]tisem5t reads3 8,bromidia's 7,battle7 ,m>k$ ,s$ative & ,antispasmodic ,qualities em95tly fit x = ! treatm5t ( ,maniacal ,excitem5t1 ,epilepsy1 ,spasmodic ,a/hma1 ,convulsive ,seizures ( ,reflex ,orig91 ,sexual ,neuroses1 & o!r disord]s att5dant ^u n]v\s irritability4 8,?r\gh its exhibition1 ! fulle/ !rapeutic p[] ( ! bromides may be secur$ ) a m9imum ( _! evil effects2 a feature ( ! greate/ s]vice :5 ! necessity = cont9u$ treatm5t becomes necess>y40 ,9 addition to ! g5]al invitation to use ,bromidia 9 epilepsy & v>i\s n]v\s disord]s1 a circul> also recomm5ds its use 9 typhoid1 a recomm5dation1 :i*1 if foll[$1 may turn ! scale 9 favor ( a fatal result4 ,! circul> /ates3 8,z a soo?+ ag5t 9 ! extreme re/lessness & irritability ( typhoid fev] & o!r infecti\s diseases1 ,,bromidia 7,battle7 is a !rapeutic weapon ( def9ite s]vice4 ,relief ( ! heada*e ( typhoid may also be secur$ ?r\gh ! use ( ,,bromidia 7,battle74 ,by means ( its adm9i/ration = ! above purposes1 ! pati5t's /r5g? is cons]v$ & z a result he is mu* bett] prep>$ to /& ! =ce ( ! infection40 ,p>ticul>ly vici\s is ! recomm5dation t x be giv5 to *ildr54 ,?us1 9 a pamphlet entitl$ 8,effective ,drugs ,effectively ,comb9$03 8,ano!r po9t ( advantage to be f\nd 9 bromidia is ! ease ) :i* x is borne by *ildr54 ,ow+ to ?is tol]ance1 x is ( di/9ct s]vice 9 a consid]able li/ ( disord]s ( *ildhood4 ,?us1 ( c\rse1 employ$ ) c>e & an und]/&+ ( its pot5cy1 bromidia has a field ( usefulness 9 *orea1 l>yngismus /ridulus1 & :oop+-c\gh4 ,9 o!r n]v\s disord]s ( *ildhood--^? att5d+ acute infections1 = in/ance--bromidia is a def9itely indicat$ !rapeutic aid1 ow+ to ! soo?+ influ5ce ex]t$ by ev5 a mod]ate dose & ! abs5ce ( unt[>d effects4 ,m specifically1 ! correct+ influ5ce ( bromidia 9 ! night-t]rors ( *ildr5 may be m5tion$40 ,=m]ly adv]tisem5ts ass]t$ t ea* fluidram ( ,bromidia conta9$3 8,*loral hydrate #ae gra9s 8,potassium bromid #ae gra9s 8,extract ( ,cannabis indica #a_/h gra9 8,extract ( h5bane #a_/h gra90 ,?is =mula also appe>s on ! label ( a sample package s5t ?r\gh ! mails dur+ #aiad4 ,a rec5t circul> conta9s a some:at diff]5t =mula4 ,in/ead ( 8#a_/h gr4 ea* ( g54 ,imp4 ,ext4 ,cannabis ,ind4 & ,hyoscyam40 z 0 =m]ly claim$1 ea* fluidram ( ,bromidia is n[ said1 n to 8conta90 b to 8repres5t10 n ! extracts b ! f> less pot5t drugs 8,cannabis indica #a_/h gra91 ,hyoscyamus #a_/h gra910 ?us3 8,*loral hydrate #ae gra9s 8,pot4 brom4 #ae gra9s 8,cannabis indica #a_/h gra9 8,hyoscyamus #a_/h gra90 ,furni%+ /ill great] v>iety1 ! labels on a rec5tly pur*as$ bottle ( ,bromidia1 :]e "u ! ,food & ,drugs ,act ! pres5ce ( n>cotic drugs mu/ be decl>$1 read3 8,alcohol #aj p] c5t41 ,*loral ,hydrate1 #ia grs4 p] ounce4 ,cannabis indica indet]m9ate 9 f9i%$ product40 8,9 ! manufacture ( ,,bromidia to ea* dra*m ( fluid us$ are add$ #ae gra9s ( pure *loral hydrate & purifi$ brom4 pot41 & #a_/h gra9 ea* ( g54 imp4 ext4 cannabis ind4 & hyosciam40 ,^! v>i\s /atem5ts z to ! composition ( ,bromidia leave "o v mu* 89 ! air40 ,z *loral & potassium bromid are easily det]m9$ & s9ce ly+ on ! labels ( widely exploit$ propriet>ies has become some:at risky rec5tly1 x is probable t ! /atem5ts on ! trade package are to be dep5d$ on & t ea* fluidram ( ,bromidia conta9s some?+ l #ab gra9s ea* ( *loral & potassium bromid & n #ae gra9s z ! m$ical pr(ession has be5 & is be+ told4 ,ph>maci/s :o h attempt$ to put up a nonpropriet>y prep>ation simil> to or1 m correctly1 hav+ ! alleg$ composition ( ,bromidia h f\nd x practically impossible to d s4 ,! reason is t extract ( cannabis indica is almo/ insoluble 9 a m5/ruum su* z t f\nd 9 ,bromidia4 ,! ,national ,=mul>y1 fir/ edition1 li/$ ,mi/ura ,*lorali et ,potassii ,bromidi ,composita ( :i* x 0 said3 8,ea* fluidram conta9s #ae gra9s ea* ( ,*loral & ( ,bromid ( ,potassium1 & #a_/h gra9 ea* ( ,extract ( ,indian ,cannabis & ,extract ( ,hyoscyamus40 ,9 ?is ! ph>maci/s attempt$ to incorporate ! cannabis indica by us+ ! t9cture ( ! drug & susp5d+ x by ! addition ( t9cture ( soap b>k4 ,9 ! pres5t edition ( ! ,national ,=mul>y1 ! prep>ation is made by triturat+ ! extract ( cannabis indica ) pumice /one & !n filt]+ ! f9i%$ product4 ,?is gives an 8elegant0 prep>ation--b "o f :i* ! cannabis indica is filt]$ out6 ,a sad comm5t>y on ! ,national ,=mul>y4 ,x %\ld n be suppos$1 h[ev]1 t ! manufactur]s ( ,bromidia h solv$ ! problem t has baffl$ ! ph>maci/s2 n at all4 ,bromidia probably conta9s no m cannabis indica ?an does its ,national ,=mul>y prototype4 ,! /atem5t on ! pres5t trade packages1 t ! am\nt ( cannabis indica 9 ,bromidia is 8indet]m9ate10 is b a t>dy ackn[l$gm5t ( ! fact t ! /uff has n1 & nev] _h1 ! am\nt ( cannabis indica claim$ = x = s _m ye>s4 ,! 8indications0 nam$ on ! ,bromidia labels are1 9 common ) no/rums ( ?is type1 b sugge/ions = self-drugg+4 ,!y w appeal to ! layman :o has pur*as$1 ei!r by prescription or o!rwise1 an 8orig9al package0 ( ,bromidia & :o may imag9e he suff]s f 8n]v\sness10 8sleeplessness10 8heada*e0 or 8neuralgia40 ,b :ile ! manufactur]s 9 _! adv]tis+ matt] h on ! :ole n disguis$ ! pres5ce ( *loral s mu* z !y h attempt$ to make x appe> t ! *loral has be5 robb$ ( its dang]s--= all hypnotics if us$ ?\ghtlessly are dang]\s--aft] all ! "n has creat$ ! false impression t ,bromidia is a bromid prep>ation4 ,x is because ( ?is false impression c>ri$ by its "n1 t ,bromidia came to be us$ indiscrim9ately by ! pr(ession & 9 ! c\rse ( "t /ill m indiscrim9ately & recklessly by ! public4 ,bromidia is a vici\s *loral prep>ation masqu]ad+ "u a mislead+ "n4 ,t physicians h be5 impress$ by ! claims ( its h>mlessness & by ! my/]y connect$ ) ! =mula is n a cr$it to ! intellig5ce ( our pr(ession4 ,!re is no d\bt b t physicians are responsible = ! use & abuse ( ?is *loral prep>ation by ! public4 ,!re is no sci5tific or rational excuse = a ready-made prep>ation ( ?is sort4 ,:5 *loral or a bromid is indicat$ ! prop] dose ( ea* ( ^!1 if !y are to be comb9$1 %\ld be det]m9$ = ea* pati5t4 ,potassium bromid & *loral hydrate bo? are readily soluble 9 wat]1 syrup or elixirs & x is a simple matt] to prescribe ! requir$ dose ( *loral & ( bromid dissolv$ 9 "s aromatic wat] l c9namon-wat] 7,aqua ,c9namomi71 9 "s syrup l syrup ( orange 7,syrupus ,aurantii7 or 9 an elixir l ! aromatic elixir 7,elixir ,aromaticum7 or adjuvant elixir 7,elixir ,adjuvans74 ,if ?is mixture is prescrib$ ?us ! physician is alive1 alike to ! dang]s & ! limitations ( ! drugs2 if x is prescrib$ "u a mislead+ propriet>y "n1 ! physician endang]s 8 pati5t1 /ultifies 8 pr(ession & t5ds to p]petuate ! great ,am]ican fraud4 ,editor's ,note4--,a li/ ( "s ( ! m$ical j\rnals t adv]tise ,bromidia3 ,texas ,m$ical ,news ,na%ville ,j\rnal ( ,m$ic9e ,surg]y ,m$ical ,brief ,annals ( ,surg]y ,*>lotte ,m$ical ,j\rnal ,m$ical ,s5t9el ,memphis ,m$ical ,mon?ly ,l>yngoscope ,m$ical ,_w ,m$ical ,review ( ,reviews ,l\isville ,mon?ly ,j\rnal ,indianapolis ,m$ical ,j\rnal ,mon?ly ,cyclop$ia ,m$ical ,bullet9 ,j\rnal ( ,n]v\s ,m5tal ,diseases ,m>yl& ,m$ical ,j\rnal ,m]ck's ,ar*ives ,i[a ,m$ical ,j\rnal ,m$ical ,/&>d ,s\!rn ,practition] ,new ,orleans ,m$ical ,surgical ,j\rnal ,!rapeutic ,gazette ,m$ical ,h]ald ,m$ical ,times ,texas ,m$ical ,j\rnal ,wiscons9 ,m$ical ,record] ,int]national ,j\rnal ( ,surg]y ,v]mont ,m$ical ,mon?ly ,atlanta ,j\rnal-,record ( ,m$ic9e ,/4 ,paul ,m$ical ,j\rnal ,hospital ,bullet9 ( ! ,univ]sity ( ,m>yl& ,d5v] ,m$ical ,times ,buffalo ,m$ical ,j\rnal ,m$ical ,review ,ell+wood's ,!rapeuti/ ,eclectic ,m$ical ,j\rnal ,massa*usetts ,m$ical ,j\rnal --7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,may #af1 #aiad47 ,,cactus ,,gr&iflorus ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry,h ,h ,a repr9t ( v>i\s articles discuss+ ,cactus ,gr&iflorus1 ,cact9--n[ call$ ,cactoid--7,abbott ,alkaloidal ,company7 & ,cact9a ,pillets 7,sultan ,drug ,company7 w be s5t on receipt ( a #b-;c5t /amp4 ,! ,c\ncil vot$ t cactus gr&iflorus %\ld n be accept$ = ,new & ,non(ficial ,rem$ies1 & t a /atem5t be prep>$ = ,! ,j\rnal giv+ ! reasons = ?is action4 ,accord+ly ! foll[+ report has be5 adopt$ by ! ,c\ncil & its publication au?oriz$4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,cactus ,gr&iflorus ,! !rapeutic value ( ?is plant has be5 v>i\sly e/imat$ by diff]5t obs]v]s4 ,exp]im5tal evid5ce z to its action is scanty & no complete *emical exam9ation has ev] be5 made4 ,reputable m5 h te/ifi$ t "s ( ! plants ( ! cactus family conta9 v active pr9ciples1 b s f> exp]im5ts seem to prove t cactus gr&iflorus has nei!r ! action ( digitalis nor t ( /ry*n94 ,! pr9cipal contributions1 cl9ical & exp]im5tal1 = & aga9/ ! drug1 are set out bel[4 ,,exp]im5tal ,,evid5ce ,o4 ,h4 ,my]s#h work$ ) a product :i* he calls cact9a & :i* he reg>ds z ! active pr9ciple ( ! drug4 7,z no su* sub/ance z cact9a is describ$ 9 any mat]ia m$ica1 x is impossible to /ate :at ,my]s really us$47 ,he f\nd t x _h a /ry*n9-l action & rais$ ! blood-pressure4 #h ,new ,york ,m$4 ,j\r41 #ahia1 liii1 #fha-fhc4 ,hat*] comes to ! conclusion3 8,ei!r ,my]s' "w 0 a pure fabrication or he 0 deal+ n ) cact9 b ) a sub/ance simil> to ! pellot9 ( ,hefft]1 ! action ( :i* resembles t ( /ry*n9 to a c]ta9 ext5t40 ,e4 ,bo9et & ,j4 ,boy-,teissi]#i exp]im5t$ ) an aque\s extract1 an alcoholic extract1 & ) an alkaloid :i* !y call 8cact9e40 ,!y conclud$ f ?ree sets ( exp]im5ts on frogs t extract ( cactus produces1 9 t5 m9utes1 a tempor>y increase 9 ! he>t's action :i* frequ5tly repeat$ doses are requir$ to ma9ta92 & t l>ge doses sl[ ! he>t & produce arrhy?mia4 #i ,bull4 gn4 de ?rap41 #ahia1 cxxi1 #cdc-cdi4 ,l4 ,e4 ,sayre#aj exp]im5t$ ) a prep>ation ( cactus1 made f ! /em ( ! plant1 by inject+ x into ! dorsal lymph space ( ! frog4 ,!re 0 seem+ly an increase 9 ! amplitude ( ! he>t's action & an indication ( a /r5g!n$ beat or increas$ =ce4 #aj ,am4 ,ph>m4 ,assn41 #aijf1 liv1 #dje4 ,r4 ,a4 ,hat*]#aa /ates t x is possible t cactus gr&iflorus1 "u c]ta9 conditions1 may conta9 a pr9ciple ) a /ry*n9-l action4 ,b ,hat*] made t5 exp]im5ts on frogs1 f\r on cats1 six on dogs1 two on rabbits1 & "o on a gu9ea-pig1 ) ,cact9a pillets ( ! ,sultan ,drug ,company & ! ,cact9 ( ! ,abbott ,alkaloidal ,company4 ,f #a to #ae pillets 9 frogs & up to #be 9 dogs 7 us$ at ea* dose4 ,9 no s+le in/ance 0 !re any evid5ce ( a digitalis-l or /ry*n9-l action1 or1 9 fact1 ( any decid$ action ( any k9d :atev]4 #aa ,! ,j\rnal ,a4 ,m4 ,a41 ,sept4 #ba1 #aijg1 pp4 #ajba-ajbd4 ,gordon ,%>p#ab 0 unable to obta9 ei!r alkaloid or glucosid f ! plant1 b f\nd a s]ies ( res9s t caus$ contraction ( ! blood-vessels ( a frog4 ,?is 0 n a digitalis-l contraction1 b dep5d$1 he believ$1 on simple acidity4 ,on ! he>t ( ! frog ! res9s h little or no effect1 comp>isons be+ made ) digitalis 9 ! same animals4 ,!re is no pro( t cactus gr&iflorus itself %ort5s dia/ole1 or 9 fact1 t x has any special action on ! he>t muscle at all4 ,%>p exp]im5t$ on himself ) l>ge doses ( an extract made ) alcohol #a to #e1 b got no noticeable results4 ,he ?9ks t ! plant may h "s slight diuretic action4 #ab ,practition]1 ,london1 #ahid1 iii1 #ddd-ddf4 ,sayre submitt$ ! prep>ation :i* he us$ 9 8 exp]im5ts = m c>eful te/+ to ,e4 ,m4 ,h\ghton1 :o report$ t x _h practically no action on ! he>t4 ,9 comm5t+ on ,h\ghton's results1 ,reid ,hunt said t !y 7 confirm$ by 8 own exp]im5ts4 ,he did n d5y1 h[ev]1 t ! drug might h "s !rapeutic effect & t1 9 v l>ge doses1 x did affect ! kidneys4 ,s4 ,a4 ,mat!ws#ac f\nd "o prep>ation ( cactus 7cact9--,abbott7 absolutely in]t s f> z any effect on ! he>t is conc]n$4 ,he f\nd t cact9a 7,sultan ,drug ,co47 9 v l>ge doses depress$ bo? ! circulation & respiration4 ,9 ?is reg>d x diff]s f /ry*n91 & x has no resemblance to ! action ( digitalis1 /rophan?us or any ( ! he>t /imulants4 ,a dose ( f #aj to #ab pillets adm9i/]$ intrav5\sly to a #aj to #ab kg4 dog ex]t$ little or no influ5ce on ! he>t or circulation2 ! l>g] dose may cause a slight fall 9 blood-pressure4 ,:5 #gj or m pillets 7 adm9i/]$ )9 two & a half h\rs ! animal g5]ally di$4 #ac ,! ,j\rnal ,a4 ,m4 ,a41 ,m>* #ba1 #aijh1 pp4 #ief-ieh4 ,! "w ( ,bo9et & ,boy-,teissi] also has be5 criticiz$ by ,hat*] on ! gr\nd t _! mo/ positive results 7 obta9$ ) an alkaloid :i* no "o at ?is day is able to prep>e4 ,! results quot$ 9 ?is report1 h[ev]1 7 obta9$ by ! use ( extracts ( cactus s t x does n seem t !y %\ld be entirely reject$1 :atev] _! value may be4 ,,cl9ical ,,evid5ce ,cl9ical obs]vations h be5 m abundant ?an exact1 & a favorable action ( ! drug 9 "s organic diseases ( ! he>t has be5 report$2 o!r obs]v]s w\ld limit its use to functional arrhy?mia1 insi/+ t x is n a sub/itute = digitalis or aconite1 b t x occupies a place di/9ct f ei!r ( ^? rem$ies4 ,p4 ,w4 ,williams#ad recomm5ds cactus = functional he>t disease1 b1 z a rule1 f\nd x useless 9 organic disease4 ,he ?9ks x "o ( a class ( rem$ies :i* act on ! accel]ator n]ves & sympa!tic ganglia1 %ort5+ ! dia/ole & /imulat+ ! sp9al vasomotor n]ve c5t]s4 ,williams app>5tly reli$ on ,my]s = 8 k ( ! ph>macologic action1 & 8 pap] is a fair example ( ! cl9ical /udies ( cactus4 #ad ,practition]1 ,london1 #ahia1 xlvii1 #bff-bgc4 ,ell+wood#ae claims t cactus is a c>diac tonic1 act+ on ! accel]ator n]ves & he>t ganglia1 increas+ muscul> =ce & art]ial t5sion4 ,he recomm5ds x 9 bo? organic & functional diseases4 #ae ,m$4 ,rec41 ,new ,york1 #aije1 lxvii1 #heg4 ,bo9et & ,boy-,teissi] f\nd t !rapeutic doses ( #dj drops ( t9cture ( cactus 7 )\t effect on ! normal he>t4 ,9 pati5ts ) noisy asy/ole 7asy/olie bruyante7 ! same dose produc$ no appreciable effect4 ,9 ! p]iod ( lat5t non-comp5sation ( true c>diac pati5ts1 f #hj to #ajj drops a day increas$ ! =ce ( ! fail+ he>t4 ,9 pati5ts ) second>y he>t disease ) arrhy?mia ( n]v\s orig91 daily doses ( #hj1 #ajj & #abj drops ( ! t9cture 7 well tol]at$ = weeks2 !y seem$ to increase ! fulness ( ! pulse & regulat$ its rhy?m4 ,9 spite ( su* l>ge doses1 ^! obs]v]s nev] notic$ any symptoms t c\ld be attribut$ to a cumulative action4 ,x mu/ be rememb]$ t ! precise prep>ation ( cactus :i* !y us$ is n kn[n4 ,aulde#af recomm5ds x z a c>diac tonic free f cumulative effects4 #af ,practition]1 ,london1 xlvii1 #bbc2 ,!rap4 ,gaz41 #ahij4 ,gordon ,%>p says3 8,! !rapeutics ( ! subject1 ,i ?9k1 are cle> en\gh4 ,cactus gr&iflorus _c be includ$ 9 our li/ ( c>diac drugs4 ,x is n ev5 a simple /oma*ic tonic & at mo/ all "o c say is t x has small diuretic action40 ,hat*] says3 8,cl9ical te/imony is s conflict+ t betwe5 ! extreme views ( ,gordon ,%>p & ^? ( ,ell+wood !re is room = an hone/ diff]5ce ( op9ion conc]n+ cactus gr&iflorus40 ,mat!ws himself took #ajj granules ( cact9 7#a_/fg gr4--#a mg4 ea*71 #be e f\r h\rs1 )\t exp]i5c+ ! lea/ effect4 ,,conclusions ,reliable conclusions reg>d+ ! !rapeutic use ( cactus gr&iflorus are r5d]$ difficult on acc\nt ( sev]al factors4 #a4 ,x is unc]ta9 :at "p ( ! plant conta9s ! active pr9ciple if "o exi/s2 & its nature is unkn[n4 ,! ,national ,/&>d ,disp5satory /ates t its 8activity mu/ be conf9$ to ! fl[] 9 "s special /age ( its developm5t or to a c]ta9 "p ( x or to "s p>ts ga!r$ ) x40 ,?is unc]ta9ty may expla9 ! negative results obta9$ by "s obs]v]s1 b x makes ! drug "o t _c be g5]ally reli$ on & gives an excell5t opportunity = ! exploitation ( propriet>y prep>ations4 #b4 ,"s ( ! exp]im5tal "w & mu* ( ! cl9ical evid5ce has be5 obta9$ & publi%$ "u propriet>y auspices4 ,= ?is reason _m ( ! !rapeutic claims made = ! drug mu/ be view$ z m]ely ! reflection ( ! exagg]at$ /atem5ts made by ! adv]tis]s ( propriet>y prep>ations4 #c4 ,! value ( cl9ical evid5ce :5 unsupport$ by an animal exp]im5tation is mu* dim9i%$ by ! t5d5cy ( en?usia/ic & untra9$ obs]v]s to attribute to ! drug giv5 ! effect really due to g5]al rem$ial measures1 psy*ic sugge/ion & s =?4 ,:ile x mu/ be admitt$ t valuable rem$ies may exi/ ^: !rapeutic prop]ties _c be reveal$ by animal exp]im5tation1 yet 9 ! abs5ce ( su* exp]im5tal evid5ce conclusions %\ld be drawn ) extreme caution4 ,be>+ ^! conditions 9 m9d1 ! foll[+ /atem5ts seem to be ju/ifi$3 7a7 ,! botanical1 *emical & ph>maceutical prop]ties ( cactus are n suffici5tly det]m9$ to make any available prep>ation a reliable rem$y4 7b7 ,!re is "s evid5ce t cactus may be capable ( affect+ ! animal he>t & n]v\s sy/em1 b its action is n t ord9>ily attribut$ to x4 ,x does n increase ! =ce ( ! he>t-beat4 7c7 ,:ile !re is "s cl9ical te/imony z to its usefulness 9 functional diseases ( ! he>t1 ! indications = its adm9i/ration are at pres5t too unc]ta9 to af=d a safe basis = recomm5d+ x4 #d4 ,:ile ! drug may be des]v+ ( fur!r exp]im5tal & cl9ical inve/igation1 ?is %\ld be c>ri$ on 9 reliable ph>macologic laboratories & 9 cl9ics provid$ ) facilities = exact obs]vation4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,m>* #ab1 #aiaj47 ,,calcreose ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,9 response to inquiries & 9 view ( ! ext5sive adv]tis+ propag&a1 ! ,c\ncil1 on ,dec4 #ai1 #aiac1 took up = consid]ation ,calcreose 7,maltbie ,*emical ,company1 ,new>k1 ,n4 ,j474 ,exam9ation %[$ t ! prep>ation conta9$1 9 loose comb9ation1 approximately equal weights ( creosote & lime4 ,! claims made 9 ! adv]tis+ 8lit]ature0 7 extravagant & uncritical1 & ! ,c\ncil !re=e held ,calcreose ineligible = ,new & ,non(ficial ,rem$ies4 ,9 ,june1 #aiad1 at ! reque/ ( ! ,maltbie ,*emical ,company1 ! ,c\ncil und]took a reconsid]ation ( ! prep>ation4 ,! adv]tis+ claims 7 n[ f\nd m cons]vative4 ,be=e ! exi/+ claims c\ld be judg$1 h[ev]1 ! ,c\ncil deem$ x necess>y to require f ! company satisfactory pro( 7#a7 t ! l>ge doses ( ,calcreose recomm5d$ & adm9i/]$ actually furni% l>ge am\nts ( creosote to ! blood1 & 7#b7 t pati5ts tak+ ^! l>ge doses d n suff] f dige/ive di/urbances1 loss ( nutrition1 album9 9 ! ur9e or ph5ol ur9e1 z claim$4 ,! ,c\ncil accord+ly advis$ ! company ( ?is requirem5t1 at ! same "t /ipulat+ t no?+ 9 ! report %\ld be int]pret$ z indicat+ a belief on ! "p ( ! ,c\ncil t enorm\s doses ( creosote are necess>y =1 or w promote a cure ( tub]culosis4 ,! ,maltbie ,*emical ,company has n up to ! pres5t date furni%$ ?is pro(1 b has ev9c$ a disposition to make ! ,c\ncil's hold+ ,calcreose "u advisem5t appe> 9 ! guise ( a quasi-approval4 ,x is !re=e recomm5d$ t ,calcreose be refus$ recognition = conflict ) ,rule #f4--7;,f ! ,j\rnal ,a4 ,m4 ,a41 ,june #bf1 #aiae47 ,,campho-,,ph5ique ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry & ,"s ,comm5ts ,!reon ,! foll[+ report 0 submitt$ to ! ,c\ncil on ,ph>macy & ,*emi/ry by ! subcommittee to :i* ,campho-,ph5ique _h be5 assign$3 ,to ! ,c\ncil on ,ph>macy & ,*emi/ry3--,campho-,ph5ique1 sold by ! ,campho-,ph5ique ,co41 ,/4 ,l\is1 ,mo41 is claim$ to be compos$ ( ph5ol #di p] c5t41 & camphor #ea p] c5t4 ,exam9ation ( specim5s1 pur*as$ 9 ! op5 m>ket1 made "u our direction1 demon/rates t ! /atem5ts made 9 reg>d to ! composition are n true4 ,in/ead ( conta9+ #di p] c5t4 ( ph5ol 7c>bolic acid71 ! analysis %[$ t x conta9s n m ?an #bj p] c5t4 ,in/ead ( conta9+ #ea p] c5t4 ( camphor1 ! analysis demon/rates t ! am\nt ( camphor is n m ?an #ch p] c5t4 ,besides ph5ol & camphor1 a ?ird sub/ance 0 f\nd :i* prov$ to be liquid petrolatum & to be pres5t to ! ext5t ( #ch p] c5t4 or m4 ,s9ce ! /atem5ts made 9 reg>d to ! composition ( ,campho-,ph5ique are delib]ate misrepres5tations ( ! facts1 x is recomm5d$ t ! article be n approv$4 ,besides ,campho-,ph5ique1 ! above-m5tion$ firm also sells a prep>ation label$ ,campho-,ph5ique ,p[d]4 ,:ile no /atem5t 9 reg>d to ! composition ( ?is product is made on ! label or 9 ! lit]ature1 su* expressions z 8,campho-,ph5ique 9 a p[d]$ =m0 & 8,p[d]$ ,campho-,ph5ique0 lead to ! inf]5ce t x has ess5tially ! same composition z t /at$ = ! liquid prep>ation4 ,an exam9ation ( a specim5 ( ,campho-,ph5ique ,p[d] pur*as$ 9 ! op5 m>ket %[$ t #ib p] c5t4 ( x 0 a talcum-l inorganic sub/ance4 ,! rema9+ #h p] c5t4 consi/$ *iefly ( camphor ) a small am\nt ( ph5ol4 ,9 view ( ! fact t ,campho-,ph5ique ,p[d] conta9s v little ph5ol1 b in/ead consi/s *iefly ( an inorganic talcum-l sub/ance1 its "n is mislead+ & deceptive4 ,x hav+ be5 %[n t ,campho-,ph5ique ,p[d] corresponds to a camphorat$ talcum p[d]1 ! claims t x 8has no equal z a dry dress+10 t x is 8absolutely sup]ior to iod(orm10 & t x has 8all ! excell5t prop]ties ( ari/ol & iod(orm10 are unw>rant$4 ,x is recomm5d$ t ! article be n approv$1 & t ?is report be publi%$4 ,! recomm5dations ( ! subcommittee 7 adopt$ by ! ,c\ncil1 & 9 accordance !re) ! above report is publi%$4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,campho-,ph5ique ,! above report on a mu* adv]tis$ 8e?ical0 propriet>y m$ic9e is wor?y ( ! ?\ghtful consid]ation ( ! memb]s ( ! m$ical pr(ession1 z x illu/rates admirably "s ( ! conditions connect$ ) ?is propriet>y m$ic9e bus9ess4 ,,! ,,=mula ,a ,,fake ,fir/1 x illu/rates ! fact t ! publi%$ =mulas ( ! 8e?ical0 propriet>ies are n always reliable4 ,! ,campho-,ph5ique ,company has be5 v will+ to give out a =mula1 purport+ _! product to be #ea p] c5t4 camphor & #di p] c5t4 ph5ol 7c>bolic acid74 ,n[1 ^! two drugs w make a liquid mixture1 & any druggi/ c make x1 & ! mixture w h ab\t ! same consi/5cy & appe>ance z ,campho-,ph5ique4 ,b its effect diff]s decid$ly f t ( ,campho-,ph5ique4 ,"s mon?s ago a v intellig5t physician1 9 discuss+ ! propriet>y m$ic9e bus9ess1 said t 9 "s cases physicians c\ld n get druggi/s to make prep>ations :i* 7 z satisfactory z ^? :i* c\ld be b\ght ready-made4 ,he cit$ ,campho-,ph5ique z an illu/ration4 ,he said t he _h us$ ?is prep>ation = burns1 etc41 b z he did n l to use prep>ations put up by companies ab\t :i* he knew no?+1 he ask$ 8 druggi/ to make ! mixture 9 accordance ) ! publi%$ =mula4 ,! druggi/'s prep>ation 0 n satisfactory2 x _h a decid$ly diff]5t effect f ,campho-,ph5ique1 & s he tri$ ano!r druggi/4 ,?is druggi/ also foll[$ ! publi%$ =mula1 b 8 results1 too1 diff]$ mat]ially f ! propriet>y article4 ,! v>i\s analyses t h be5 made %[ :y ! prep>ations put up by ! druggi/s did n resemble t made by ! company2 s9ce1 accord+ to ! analyses1 ,campho-,ph5ique consi/s ( #dj p] c5t4 liquid petrolatum1 :i* is an in]t b soo?+ dilu5t1 :ile in/ead ( #di p] c5t4 ( c>bolic acid1 z claim$1 x really conta9s less ?an #bj p] c5t4 ,?is is an entirely diff]5t proposition4 ,n[1 if ! physician ref]r$ to above w h 8 druggi/ make a mixture ( #bj p] c5t4 ( c>bolic acid1 #dj p] c5t4 ( camphor & #dj p] c5t4 ( liquid petrolatum1 & w !n comp>e ?is result+ comp\nd ) ,campho-,ph5ique1 he w f9d t !re is n mu* diff]5ce4 ,fur!rmore1 he w realize t !re is no?+ ei!r new or wond]ful ab\t ! prep>ation4 ,camphorat$ oil & c>boliz$ oil are bo? 9 common use4 ,campho-,ph5ique is app>5tly simply a mixture ( ! two4 ,,! ,,p[d] ,,/ill ,,worse ,s mu* = ! liquid4 ,! p[d] seems to be some?+ entirely diff]5t1 =1 accord+ to ! *emi/'s report1 ov] #ij p] c5t4 ( x is in]t1 absorb5t1 talcum-l mat]ial4 ,!re is en\gh camphor & c>bolic acid to give ! p[d] an odor & ?us mislead physicians1 especially ^? :o are 9 ! habit ( tak+ = grant$ t :atev] /atem5ts no/rum manufactur]s make are true4 ,p]haps x is a fairly good dress+ = w\nds--at lea/ x w d no h>m--b its "n is mislead+ & deceptive4 ,= all practical purposes x is ess5tially a camphorat$ talcum p[d]4 ,,company ,a 8,,pat5t-,,m$ic9e0 ,,conc]n ,! second int]e/+ phase ( ?is 8e?ical0 propriet>y is t x illu/rates ano!r po9t1 i4 e41 t _m ( ^! articles are suppli$ to our pr(ession by ^? :o are n legitimate manufactur+ ph>maci/s4 ,! ,campho-,ph5ique ,company ( ,/4 ,l\is1 accord+ to all reports1 is own$ & controll$ by a g5tleman nam$ ,ball>d4 ,?is 8company0 supplies ! m$ical pr(ession ) ! prep>ations "u consid]ation & also ) ,*loro-,ph5ique & ,scr(onol4 ,we are in=m$ t ?is same ,mr4 ,ball>d is ! pr9cipal own]1 if n ! sole own]1 ( q a numb] ( 8pat5t-m$ic9e0 companies1 su* z ,ball>d-,sn[ ,l9im5t ,co41 ,br[n's ,iron ,bitt]s ,co41 ,mayfield ,m$ic9e ,mfg4 ,co41 ,smi? ,bile ,beans ,co41 ,swa9's ,laboratory1 & sev]al o!rs4 ,we le>n f ! :olesale drug trade li/s t ^! v>i\s 8companies0 make & sell1 besides ! ,campho-,ph5ique prep>ations1 ,ball>d-,sn[ ,l9im5t1 ,ball>d's ,h]b9e1 ,br[n's ,iron ,bitt]s1 ,dr4 ,h]rick's ,pills1 ,ri*>dson's ,life-,pres]v+ ,bitt]s1 ,smi?'s ,bile ,beans1 ,swa9's ,all ,heal+ ,o9tm5t1 & sev]al o!r 8pat5t m$ic9es40 ,x is h>dly necess>y to make any fur!r comm5ts4 ,! :ole bus9ess is nauseat+ to ^? :o "k ! actual conditions ( ?is no/rum bus9ess & h[ our pr(ession is be+ delud$4 ,! ,campho-,ph5ique matt] is n an exception2 x is simply ano!r illu/ration ( ^! conditions4 ,! majority ( 8e?ical0 propriet>ies are foi/$ on our pr(ession1 ei!r )\t any =mula accompany+ !m1 or ) a 8=mula0 t is a fake4 ,! majority ( ! 8e?ical0 propriet>ies are manufactur$ & suppli$ to physicians1 ) in/ructions reg>d+ _! use1 by m5 :o be> ! same relation to legitimate ph>macy t ! v]ie/ quack t ev] sw9dl$ a cr$ul\s public be>s to sci5tific m$ic9e4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,april #bj1 #aijg47 ,,cel]9a1 ,,aletris ,,cordial ,,& ,,k5n$y',s ,,p9us ,,canad5sis1 ,,light ,,& ,,d>k ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! foll[+ reports on products ( ! ,rio ,*emical ,company h be5 submitt$ by a ref]ee4 ,! ,c\ncil recomm5ds t !y be publi%$1 z ! prep>ations discuss$ are gl>+ in/ances ( no/rums exploit$ ?r\gh physicians on unsci5tific claims & false repres5tations4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,cel]9a ,cel]9a belongs to :at ,samuel ,hopk9s ,adams calls ! 8brac]0 type ( no/rum4 ,accord+ to ! label x conta9s #db p] c5t4 alcohol 7:isky conta9s ab\t #ej p] c5t474 ,! o!r +r$i5ts ( ,cel]9a are decl>$ to be z foll[s3 8,ea* fluid\nce repres5ts ,=ty gra9s ea* ,kola1 ,viburnum1 ,=ty-eight gra9s ,cel]y1 ,tw5ty gra9s ,cyprip$ium1 ,sixte5 gra9s ,xan?oxylum & ,aromatics4 8,dose--#a or #b teaspoonfuls #c times a day40 ,kola conta9s a v small p]c5tage ea* ( caffe9 & !obrom94 ,x is impossible = ! inf9itesimal am\nts ( ^! alkaloids 9 an ord9>y dose ( ,cel]9a to produce any physiologic effect4 ,viburnum has be5 call$ a 8ut]9e s$ative10 :atev] t may be4 ,its only real activity is ! psy*ic "o due to its ta/e & odor4 ,cel]y at "o "t 0 cr$it$ ) be+ bo? an antispasmodic & a n]ve /imulant--a rem>kable comb9ation ( oppos+ qualities6 ,sci5tific inve/igation has fail$ to %[ t cel]y has any physiologic or !rapeutic activities4 ,if x _h ! slighte/ m$ic9al value1 ! rational c\rse w\ld be to prescribe x 9 its fre% & natural /ate4 ,! small dose conta9$ 9 a teaspoonful ( ,cel]9a is inappreciable & n ev5 equival5t to t conta9$ 9 a /alk ( cel]y4 ,ladyslipp]1 m impos+ "u ! ,lat9 "n ( 8cyprip$ium10 is a fl[]+ plant ) a leg5d>y reputation z an 8antispasmodic & n]ve /imulant40 ,x has be5 9 ! !rapeutic scrap-heap = ye>s4 ,x conta9s a little tannic acid1 gallic acid & a volatile oil4 ,ev5 a tannic acid action _c be expect$ f a teaspoonful ( a prep>ation conta9+ #bj gra9s ( ladyslipp] to ! ounce4 ,prickly a% 7xan?oxylum7 has nev] be5 %[n to h any activity o!r ?an t ( a local irritant1 especially to muc\s membranes4 ,! slight 8bite0 f ?is drug w\ld be entirely cov]$ up by ! alcohol 9 ,cel]9a4 ,any /imulat+ effect :i* ?is drug may h on ! /oma* is greatly inf]ior to t produc$ by a v small glass ( ord9>y g+] ale4 ,9 %ort1 !re is no +r$i5t 9 ,cel]9a1 except ! alcohol1 t has any recognizable activity2 & ! alcohol cont5t is ne>ly z great z t ( ord9>y :isky4 ,"s ( ! claims & recomm5dations = ?is no/rum are3 8,cel]9a 7,n]ve ,tonic71 = ,n]v\sness1 ,hy/]ia1 ,insomnia1 ,n]v\s ,indige/ion1 ,languid & ,debilitat$ ,conditions1 ,recov]y f ,alcoholic ,excess40 ,?9k ( prescrib+ an alcoholic no/rum f\r times a day to promote recov]y f alcoholic excess6 8,,neura/h5ia3 ,! bane ( ! g5]al practition]2 ! puzzle ( ! neurologi/2 ! juicy fruit ( ! quack & faddi/2 ! opportunity ( ! intellig5t !rapi/4444 ,= ! m$ical treatm5t ,,cel]9a is ! prep>ation ( wide utility40 ,! sang froid ) :i* ! exploit]s ( ?is no/rum ref] to o!r 8quacks & faddi/s0 z reap+ 8juicy fruit0 f neura/h5ics w\ld comm& admiration 7 x n s pitiful4 8,cel]9a has sub/antial endorsem5t 9 n]v\s disord]s *>act]iz$ by ,aphonia 7n]v\s740 ,( c\rse1 ! disappe>ance ( n]v\s aphonia might foll[ ! application ( any treatm5t :atev]1 be x ,eddyism1 ,*iropractic1 ,p]una or ,cel]9a4 ,9 8,,climact]ic 7! ,m5opause7 flatt]+ results h be5 report$ f a comb9ation ( equal p>ts ,cel]9a & ,aletris ,cordial ,rio40 8,teaspoonful doses aft] meals & ^u retir+ h prov5 efficaci\s 9 8dyspepsia0 :5 o!r rem$ies h fail$40 ,"h is a good example ( propriet>y-h\se !rapeutics3 ,su* widely diff]5t conditions z dige/ive tr\ble & ! climact]ic are to be treat$ ) a comb9ation ( alcohol1 simple bitt]s & aromatics6 ,:y n ord] a cocktail "u its own "n8 ,x w\ld be equally efficaci\s1 less my/]i\s & its dang]s might be bett] realiz$6 8,a teaspoonful or two 9 ?ree tablespoonfuls ( boil+ hot wat] = insomnia ^u retir+40 ,any o!r hot toddy at b$time 7& x ne$ n co/ a doll> a bottle7 might give relief2 b ! intellig5t physician to-day recognizes ! dang] ( prescrib+ alcohol 9 su* conditions4 8,9 ! case ( bra9 work]s :o suff] f n]v\s excitability & m5tal fatigue1 ! adm9i/ration ( ,cel]9a 9 teaspoonful doses1 ?ree times a day & at b$time1 rapidly controls ! condition & increases m5tal capacity40 ,& ! same effect foll[s its use3 8,9 cases involv+ worry1 anxiety1 ov]work1 & excesses ( v>i\s k9ds44440 ,moreov]3 8,cel]9a is ! mo/ prompt & effici5t ( rem$ies = devitaliz$ or brok5-d[n con/itutions--doses f\r times a day40 ,! /atem5t made by its manufactur]s t ?is prep>ation is free f n>cotics or habit-=m+ drugs is n true4 ,alcohol is bo? a n>cotic & a habit-=m+ drug4 ,z 9 ! case ( o!r no/rums conta9+ no pot5t drugs b alcohol1 ,cel]9a is recomm5d$ = v>i\s diseas$ conditions 9 comb9ation ) a famili> =m ( treatm5t by drugs ( m or less value4 ,! physician :o ?\ghtlessly prescribes "o ( ^! comb9ations w )\t d\bt un?9k+ly attribute any subsequ5t improvem5t to ! ,cel]9a4 ,?us1 = mal>ia1 a prescription ( qu99 & ,cel]9a is advis$2 = *orea 9 *ildr51 ars5ic ) ,cel]9a2 9 8,convalesc5ce f ,la ,grippe10 /ry*n9 sulphate1 ,f[l]'s solution1 & ,cel]9a2 = impot5ce1 nux vomica1 dilute phosphoric acid & ,cel]9a4 ,9 none ( ^! conditions w\ld ,cel]9a affect favorably any?+ except ! pockets ( ! exploit]s2 9 "s1 z 9 ! *orea ( *ildr51 ! alcohol w\ld be positively detrim5tal4 ,( c\rse1 ! value ( su* prescriptions 7s f> z !y h any ap>t f ! fictiti\s value l5t by ! alcohol7 resides altoge!r 9 ! /&>d drugs prescrib$ ) ,cel]9a4 ,!re is no possible excuse = writ+ a prescription = ,cel]9a1 ei!r 9 orig9al package or mix$ ) well-kn[n or valuable drugs4 ,! soon] x is realiz$ t ?is prep>ation has no place 9 m$ic9e1 %\ld nev] be prescrib$ by physicians & is ess5tially no?+ b alcohol & bitt]s exploit$ "u a fancy "n1 ! bett] = ! public heal? & ! sci5ce ( m$ic9e4 ,! cont9u$ sale & use ( ,cel]9a is a disgrace to ! m$ical pr(ession4 ,aletris ,cordial ,aletris ,cordial is a no/rum conta9+ !rapeutically wor?less drugs 9 alcohol 7#bh p] c5t474 ,! 8=mula0 on ! label reads3 8,ea* fluid\nce repres5ts t5 gra9s ,aletris1 ?irty gra9s ,helonias & ?irty gra9s ,scrophul>ia40 ,at "o "t ^! drugs _h "s vogue1 *iefly z dome/ic rem$ies4 ,!y h be5 disc>d$ z valueless by mod]n sci5tific m$ic9e4 ,aletris1 or unicorn root 7,aletris f>9osa71 conta9s a bitt] pr9ciple & />*4 ,! rem>kable ut]9e tonic prop]ties =m]ly ascrib$ to x h n be5 confirm$ by reliable obs]v]s4 ,x is practically wor?less4#ag #ag ,see ,unicorn ,root1 ,wild ,yam1 & ,wild ,indigo1 p4 #bjh4 ,helonias1 or false unicorn 7,*amaelirium luteum71 is ass]t$ to be a hemo/atic & ut]9e tonic4 ,no tru/wor?y evid5ce has ev] be5 (f]$ 9 support ( ! claims made = ?is drug2 reliable m$ical lit]ature conta9s no ref]5ce to x2 x has no valid claim on ! att5tion ( physicians4#ah #ah ,see ,false ,unicorn 7,helonias71 p4 #hd4 ,scrophul>ia1 or figwort 7,scrophul>ia m>il&ica71 conta9s a pr9ciple :i* has a digitalis-l action on ! he>t4 ,its activity is s slight 9 comp>ison ) t ( digitalis1 h[ev]1 t !re 0 no?+ to be ga9$ by /udy+ x4 ,! drug is consequ5tly little kn[n & is n m5tion$ 9 critical works on ph>macology4 ,if ! drug 7 !rapeutically active 9 ! quantities us$1 ano!r dang] w\ld be add$ to t ( ! alcohol cont5t ( ,aletris ,cordial4 ,s9ce ! recomm5d$ dose 7a teaspoonful7 conta9s1 if ! =mula be correct1 only ab\t #d gra9s ( figwort1 ?is drug too may be reg>d$ z practically in]t 9 ?is prep>ation4 ,n "o ( ^! drugs has be5 deem$ wor?y ( m5tion 9 ! ,ph>macopeia4 ,! ,c\ncil has previ\sly discuss$ !m & decl>$ !m valueless 7,reports ,c\ncil ,ph>m4 & ,*em41 #aiji1 p4 #adf2 #aiaj1 p4 #aj2 #aiab1 p4 #db74 ,9 ,aletris ,cordial1 !n1 !re is no +r$i5t capable ( produc+ any o!r effect ?an ! alcohol /imulation & su* psy*ic effect z may be due to ! bitt] ta/e4 ,yet physicians are ask$ to believe t 8,probably no rem$y is s uni=mly successful 9 ! prev5tion ( ?reat5$ misc>riage z ,,aletris ,,cordial ,rio40 8,,habitual ,,misc>riage c be effectually ov]come by ! sy/ematic use ( ,aletris ,cordial ,rio40 8444 regulates ! local circulation & imp>ts normal tone & /r5g? to ! ut]9e muscle40 8,! use ( ,aletris ,cordial ,rio ?r\gh\t pregnancy goes f> to assure normal1 uncomplicat$ labor40 ,su* claims z ^!1 :5 made = a mixture conta9+ no !rapeutically active con/itu5t except alcohol1 are absolutely prepo/]\s4 ,x %\ld be not$ t ! decl>$ alcohol cont5t ( ,aletris ,cordial is mu* high] ?an t ( ! /ronge/ w9es1 &1 9 ! light ( m$ical exp]i5ce1 q high en\gh to promote ! =mation ( ! alcohol habit 9 a /eady us]4 ,! foll[+ recomm5dation1 tak5 f ! company's 8,budd+ into ,womanhood0 circul>1 !re=e1 is outrage\s3 8,_m m$ical practition]s recomm5d to mo!rs ! use ( ,aletris ,cordial ,rio = _! gr[+ daught]s1 rang+ 9 age f twelve to eighte5 ye>s44440 ,x is to be hop$ t no m$ical practition] is s he$less ( consequ5ces z to prescribe = adolesc5t girls a wor?less no/rum capable ( creat+ a crav+ = alcohol4 ,! temp]ance societies might ) pr(it take /eps to in=m laym51 especially wom51 conc]n+ ! wor?lessness ( ?is no/rum1 ! risk involv$ 9 tak+ x1 & ! outrage\s "* ( ! recomm5dations made = x by ! manufactur]s4 ,k5n$y's ,p9us ,canad5sis1 ,light & ,d>k 7,abican & ,d>p97 ,k5n$y's ,p9us ,canad5sis1 ,light 7rec5tly r5am$ 8,abican07 & ,d>k 7r5am$ 8,d>p907 are also exploit$ by ! ,rio ,*emical ,company4 ,al?\gh !y h be5 on ! m>ket "s ?irty or =ty ye>s !y appe> to h a*iev$ no m>k$ degree ( comm]cial success4 ,yet !y h be5 imitat$ by mo/ ( ! ph>maceutic h\ses4 ,!y are ( int]e/ *iefly ?r\gh ! b>efac$ fraud involv$ 9 _! exploitation4 ,,composition ,,claim$ ,app>5tly ! d>k prep>ation 78,d>p907 0 fir/ put on ! m>ket2 !n ! light "o 78,abican07 0 (f]$1 to be us$ only 8z an injection & ext]nally40 ,! reason = ! exi/5ce ( ! light prep>ation evid5tly 0 ! objectionable prop]ty ( ! d>k1 :i* /a9$ l954 ,! two prep>ations are bo? said to be extracts ( ,p9us ,canad5sis or hemlock b>k4 ,a circul> issu$ "s ye>s ago conta9$ ! foll[+ /atem5t3 8,p9us ,c4 7,k547--,d>k--,a non-alcoholic extract ( ,p9us ,canad5sis1 to ea* fluid\nce ( :i* is add$ #j4dh gra9s ,?ymol4 8,p9us ,c4 7,k547--,light--,a non-alcoholic extract ( ,p9us ,canad5sis1 to ea* fluid\nce ( :i* is add$ #bd gra9s ea* ( pure ,alum ,pota% & ,sulphate ( ,z9c & #j4dh gra9s ( ,?ymol40 ,! labels on ! packages ( ! light & d>k prep>ations s5t out to-day be>1 respectively1 only ! foll[+ ref]5ces to composition1 ! fir/ on ! d>k & ! second on ! light3 8,ea* fluid\nce also conta9s #j4dh gra9s ,?ymol40 8,a non-alcoholic prep>ation ( ,p9us ,canad5sis1 to :i* is add$ tw5ty-f\r gra9s ea* pure alum pota% & sulphate ( z9c & #j4dh gra9s ?ymol to ! fluid\nce40 ,,actual ,,composition 8,d>p90 or ,k5n$y's ,p9us ,canad5sis1 ,d>k1 does conta9 tann91 b1 z ! simple/ ( *emical te/s demon/rate1 ,p9us ,canad5sis1 ,light1 does n conta9 tann94 ,x might z tru?fully be call$ maple syrup or beef tea4 ,x is almo/ a "w ( sup]]ogation to discuss ! !rapeutic claims made = prep>ations sold "u false pret5ses z to composition4 ,x is en\gh to m5tion t ,k5n$y's ,p9us ,canad5sis1 ,d>k or ,light1 is recomm5d$ 9 ,album9uria ,di>rhea-,dys5t]y ,fetid ,p]spiration ,endometritis ,fissures ,fi/ula ,gonorrhea ,hemorrhage f ! ,nose ,ut]9e ,hemorrhage ,leucorrhea ,nasal & ,ph>yngeal ,cat>rh ,piles ,sore ,?roat ,ulc]ation ( ! ,c]vix ,! intellig5t physician ( to-day kn[s t 8 =efa!rs 9 ! days ( ! /age-coa* employ$ tannic acid 9 its crude =m & treat$ inte/9al disease 9 a v unsatisfactory mann]2 he kn[s1 fur!r1 t advances 9 our k ( pa?ology h r5d]$ ! use ( tannic acid 9 ga/ro-inte/9al !rapeutics l>gely unnecess>y & t :5 x is us$ x %\ld be 9 "s =m t w pass ! /oma* un*ang$4 ,s f> z its use z local application is conc]n$1 he kn[s1 )\t ne$ ( in/ruction f ! ,rio ,*emical ,company1 :5 tann9 is indicat$1 & ! ,ph>macopeia furni%es a suitable prep>ation = ! physician s t he ne$ n resort to an unsci5tific no/rum l ,d>p94 ,! physician :o is compet5t to treat a case ( gonorrhea does n ne$ to be told t alum & z9c sulphate may be useful 9 su* conditions1 & he does n want !m palm$ (f on him = some?+ else "u ! "n ( ,p9us ,canad5sis1 ,light1 ,abican or :at n4 ,also1 he pref]s to use !m1 :5 !y are ne$$1 s+ly & 9 /r5g? suit$ to ! conditions ( ! individual case4 ,editorial ,comm5t4--,cel]9a1 ,aletris ,cordial & ,k5n$y's ,p9us ,canad5sis1 ,light & ,d>k1 appe> to be ! entire output ( ! ,rio ,*emical ,company1 :i* 0 "o ( ! e>lie/ ( ! v>i\s companies organiz$ by ,james ,j4 ,lawr5ce ( ,m$ical ,brief fame4 ,! bus9ess 0 mov$ f ,/4 ,l\is to ,new ,york ,city 9 #aija4 ,accord+ to :at we believe to be reliable in=mation1 ! ,rio ,*emical ,company is n[ compos$ ( ,james ,p4 ,dawson1 presid5t2 ,william ,w4 ,conley1 vice-presid5t & treasur]2 & ,e4 ,d4 ,p9k]ton1 secret>y4 ,^! also con/itute ! directors4 ,x appe>s t ,james ,p4 ,dawson is a memb] ( ! law firm ( ,dawson & ,g>v51 ,/4 ,l\is2 ,e4 ,d4 ,p9k]ton is said to be ,miss ,effie ,d4 ,p9k]ton1 /5ograph] = ,dawson & ,g>v54 ,we "k little conc]n+ ,william ,w4 ,conley except t he appe>s to be 9 *>ge ( ! e/abli%m5t 9 ,new ,york4 ,we f9d no evid5ce t he is ei!r a *emi/ or a ph>maci/2 8 "n does n appe> 9 ! memb]%ip li/ ( ! ,am]ican ,*emical ,society or ( ! ,am]ican ,ph>maceutical ,association1 nor c we discov] t he has publi%$ any?+ 9 ! way ( *emi/ry or ph>macy4 ,z a matt] ( fact1 ! ,rio ,*emical ,company is ano!r ( ! pseudo-*emical companies creat$ to exploit "o or m propriet>ies--9 ?is in/ance ,cel]9a1 ,aletris ,cordial & ,p9us ,canad5sis4 ,! foll[+ m$ical j\rnals c>ry adv]tisem5ts ( ! ,rio products 7or did late 9 #aiad73 ,am]ican ,j\rnal ( ,surg]y1 ,am]ican ,m$ic9e1 ,d5v] ,m$ical ,times & ,utah ,m$ical ,j\rnal1 ,eclectic ,m$ical ,j\rnal1 ,int]national ,j\rnal ( ,surg]y1 ,int]/ate ,m$ical ,j\rnal1 ,massa*usetts ,m$ical ,j\rnal1 ,m$ical ,brief1 ,m$ical ,c5tury1 ,m$ical ,c\ncil1 ,m$ical ,review ( ,reviews1 ,m$ical ,s5t9el1 ,m$ical ,/&>d1 ,texas ,m$ical ,j\rnal & ,woman's ,m$ical ,j\rnal44--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,feb4 #ac1 #aiae47 ,,c9]>ia ,,m>itima ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,occasional inquiries 9 reg>d to ! !rapeutic value ( ,c9]>ia m>itima caus$ ! ,c\ncil to consid] ! drug ) ref]5ce to its fitness = inclusion 9 ,n4 ,n4 ,r4 among non-(ficial1 non-propriet>y rem$ies4 ,! foll[+ report1 hav+ be5 submitt$ to ! ,c\ncil by a subcommittee1 0 adopt$ & its publication au?oriz$4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,to ! ,c\ncil3--,! juice ( a plant ref]r$ to z ,c9]>ia m>itima 0 at "o "t suppos$ to be ( value 9 ! treatm5t ( cat>act & c]ta9 o!r affections ( ! eye4 ,no sci5tific evid5ce is available to %[ t ! drug is !rapeutically active1 & its value is no d\bt correctly e/imat$ by ,dr4 ,casey ,wood1 :o 78,oph?almic ,!rapeutics10 p4 #ddf2 ,clevel& ,press1 ,*icago1 #aiji7 says3 8,/ill1 a few respectable names h be5 associat$ ) its ,c9]>ia m>itima employm5t 9 t capacity & x only rema9s to be said t ! in/illation into ! conjunctival sac ( a prep>ation ( ?is or any o!r memb] ( ! ,s5ecio family has ab\t z mu* effect on ! resolution or disp]sal ( opacities due to organic *anges 9 ! l5s z p\r+ ! same d[n ! back ( ! pati5t's neck60 ,! plant f :i* ,c9]>ia m>itima juice is claim$ to be prep>$ is commonly ref]r$ to 9 lit]ature z ,c9]>ia m>itima1 b is m correctly describ$ z ,s5ecio c9]>ia1 ,d4 ,c4 ,x may be consid]$ a matt] ( indiff]5ce :e!r a rem$y l ?is be adv]tis$ = ! treatm5t ( su* diseases z cat>act1 provid+ its application c\ld d no h>m1 b x mu/ be rememb]$ t x is recomm5d$ also = o!r diseases ( ! eye 9 :i* its use1 by po/pon+ effici5t treatm5t1 w\ld be ! means ( s]i\s damage or ev5 loss ( vision4 ,s9ce !re is no evid5ce to %[ t ?is drug is ( any !rapeutic value1 x is recomm5d$ t x be n admitt$ to ! li/ ( non-(ficial1 non-propriet>y rem$ies 9 ,n4 ,n4 ,r41 & t ! ,c\ncil =mally expresses its op9ion t ! drug1 z judg$ by ! evid5ce :i* is available1 is )\t value 9 ! treatm5t ( cat>act or simil> diseases ( ! eye4 ,editorial ,comm5t4--,c9]>ia m>itima w\ld long s9ce h be5 relegat$ to ! limbo ( disc>d$ & discr$it$ drugs _h x n be5 giv5 a semipropriet>y "* by a ,/4 ,l\is no/rum h\se--! ,walk] ,ph>macal ,company--:i*1 l ! ,manola ,*emical ,company1 is1 we und]/&1 practically a subsidi>y conc]n ( ! ,luyties ,homeopa?ic ,ph>macy ,company4 ,! ,walk] conc]n exploits ?is drug "u ! "n ,succus ,c9]>ia ,m>itima 7,walk]74 ,its me?od ( exploitation consi/s 9 publi%+ te/imonials1 :i* x dignifies ) ! "n 8cl9ical reports10 f m5 :om x designates z 8repres5tative physicians40 ,z indicative ( :at con/itutes repres5tative physicians1 we f9d t ( ! sev5 te/imonials giv5 9 _! pamphlet ! names ( ?ree ( ! sign]s are n to be f\nd 9 any m$ical directory4 ,! exploitation ( ,succus ,c9]>ia ,m>itima 7,walk]7 is ! (t-repeat$ /ory ( ! resurrection ( disc>d$ & wor?less drugs = ! purpose ( creat+ proprietor%ip 9 a no/rum4 ,c9]>ia m>itima is wor?less2 its !rapeutic value is nil4 ,by ! prodigal use ( pr9t]s' ink1 ! m$ical pr(ession--& ?r\gh x ! public--has be5 humbugg$ into believ+ t x possesses curative value4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #aa1 #aiaa47 ,,hagee',s ,,cordial ,,( ,,! ,,extract ,,( ,,cod ,,liv] ,,oil ,,comp\nd,i ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,i ,see also ! reports on ,wampole's ,prep>ation & ,wat]bury's ,comp\nd1 foll[+ ?is2 also ,hagee's ,cordial1 p4 #bhi2 ,! ,comp>ative ,nutri5t ,value ( ,cod ,liv] ,oil & ,cod ,liv] ,oil ,cordials1 p4 #ddb4 ,?is is "o ( ! 8oilless0 cod liv] cordials4 ,l o!r manufactur]s ( su* extracts1 ! ,ka?>mon ,*emical ,company1 ,/4 ,l\is1 :i* owns ,hagee's ,cordial1 attempts to trade on ! reputation long enjoy$ by cod liv] oil z a promot] ( gr[? & nutrition4 ,! foll[+ is ! /atem5t ( composition furni%$ by ! company3 8,ea* fluid ounce ( ,hagee's ,cordial ( ! extract ( ,cod ,liv] ,oil ,comp\nd repres5ts ! extract obta9able f #a_/h fluid ounce ( ,cod ,liv] ,oil 7! fatty portion be+ elim9at$71 #f grs4 ,calcium ,hypophosphite1 #c grs4 ,sodium ,hypophosphite1 #a_/b gr4 ,salicylic ,acid 7made f ,oil ,w9t]gre571 ) ,glyc]9 & ,aromatics40 ,& "h are "s ( ! !rapeutic claims3 8,tonic1 ,/imulant1 ,alt]ative1 ,recon/ructive1 ,nutritive & ,dige/ive40 8,useful 9 ph?isis pulmonalis1 scr(ula & all *ronic pectoral compla9ts1 c\ghs1 colds1 bra9 exhau/ion1 n]v\s debility1 palsy1 *ronic cutane\s eruptions & impair$ dige/ion40 ,( c\rse1 ^! absurd claims h>k back to ! "t ( ! preval5ce ( ! n[ disc>d$ !ory t ! valuable prop]ties ( cod liv] oil reside1 n 9 ! fat1 b 9 c]ta9 nitrog5\s1 alkaloid-l con/itu5ts pres5t 9 inf9itesimal am\nts4 ,fur!r 8play+ up0 ?is !ory3 8,! prescrib] may "k t 9 our prep>ation he is gett+1 9 easily assimilable & palatable =m1 ! v prop]ties t make cod liv] oil ! be/ ( recon/ructives4 8,:5 y prescribe cod liv] oil y are aft] ! active pr9ciples--:y n give ! active pr9ciples !mselves40 ,propriet>y manufactur]s usually ignore sci5tific inve/igations :i* e/abli% facts adv]se to propriet>y claims2 b ! same propriet>y manufactur]s are quick to seize on any !ory t c be twi/$ into support ( _! int]e/s4 ,?us1 rec5t inve/igations hav+ %[n t cod liv] oil1 l butt] & egg yolk1 possesses c]ta9 gr[?-promot+ prop]ties n f\nd 9 "s o!r fats1 ! promot]s ( ,hagee's ,cordial claim ^! prop]ties ( cod liv] oil = _! extract4 ,!y ass]t3 8,rec5t ,*emical ,inve/igations ( ,cod ,liv] ,oil %[ t ! active pr9ciples conta9 ! nutritive qualities attribut$ to ! :ole oil40 ,! ,c\ncil has previ\sly express$ ! op9ion#ai t ! prepond]ance ( evid5ce indicates t :atev] !rapeutic value cod liv] oil may h dep5ds *iefly1 if n entirely1 on its fat 7oil74 ,!re nev] 0 any evid5ce or sci5tific au?ority = ! !ory t ! !rapeutic value ( cod liv] oil 0 indep5d5t ( its fat cont5t4 ,! fact t ! fat is ! gr[?-promot+ elem5t has already be5 %[n1 & ,j4 ,p4 ,/reet1 *emi/ = ! ,connecticut ,agricultural ,exp]im5t ,/ation 7,! ,j\rnal ,a4 ,m4 ,a41 ,feb4 #bj1 #aiae1 p4 #fch71 9 a s]ies ( exp]im5ts on a numb] ( ! s-call$ extracts ( cod liv] or cod liv] oil 7includ+ ,hagee's ,cordial7 has conclusively demon/rat$ t ! gr[?-promot+ prop]ties ( ! oil are n to be f\nd 9 ! extracts4 ,/reet plac$ rats on a ration n suffici5t to ma9ta9 normal nutrition & gr[? = an ext5d$ p]iod4 ,aft] ! rats _h be5 on ?is ration = "s "t & a failure to ma9ta9 weight 0 indicat$1 an am\nt ( dealcoholiz$ ,hagee's ,cordial 0 sub/itut$ = a portion ( ! l>d conta9$ 9 ! ration4 ,lat] ,hagee's ,cordial 0 replac$ by cod liv] oil4 #ai ,! ,j\rnal ,a4 ,m4 ,a41 ,oct4 #i1 #aiji1 p4 #abja4 ,/reet says3 8,none ( ! f\r rats did well on ,hagee's ,cordial2 9 fact1 !y lo/ #a4b to #ae4d gm4 dur+ fe$+ p]iods ( f sev5 to f\rte5 days40 8,! rats fail$ s quickly :5 put on ,hagee's ,cordial t 9 two cases ! animals did n recov] ev5 :5 put on ! full cod liv] oil ration40 8444 ! f\r rats dur+ ! ,hagee p]iod1 in/ead ( ga9+ ! normal #bd gm41 actually lo/ #cf4b gm41 :ile dur+ ! cod liv] oil p]iod in/ead ( ga9+ #aad gm41 !y ga9$ #aef4d gm40 8,! inf]iority ( ,hagee's ,cordial z a recon/ructive & a nutri5t comp>$ ) ord9>y cod liv] oil is app>5t40 ,hagee's ,cordial ( ! ,extract ( ,cod ,liv] ,oil ,comp\nd has nei!r ! nutritive qualities nor ! recon/ructive efficacy ( cod liv] oil4 ,?is mixture is wor?less = ! conditions = :i* x is adv]tis$1 & is m>ket$ "u mislead+ & unw>rant$ claims4 ,x is recomm5d$ t ,hagee's ,cordial be held ineligible = ,new & ,non(ficial ,rem$ies4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,april #aj1 #aiae47 ,,wampole',s ,,p]fect$ ,,& ,,ta/eless ,,prep>ation ,,( ,,an ,,extract ,,( ,,cod ,,liv],j ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,j ,see also reports on ,hagee's ,cordial prec$+ & ,wat]bury's ,comp\nd foll[+ ?is2 also ,! ,comp>ative ,nutri5t ,value ( ,cod ,liv] ,oil & ,cod ,liv] ,oil ,cordials1 p4 #ddb4 ,wampole's ,prep>ation is ano!r ( ! oil-free 8extracts0 ( cod liv]4 ,! foll[+ =mula 7:i*1 be x obs]v$1 is non-quantitative & !re=e practically wor?less7 is publi%$ by ! own]s1 ,h5ry ,k4 ,wampole ,co41 ,inc43 8,conta9s a solution ( an extractive obta9able f fre% cod liv]s1 ! oily or fatty portion be+ aft]w>d elim9at$4 ,?is extractive is comb9$ ) ,liquid ,extract ( ,malt1 ,fluid ,extract ( ,wild ,*]ry & ,comp\nd ,syrup ( ,hypophosphites 7conta9+ ,calcium1 ,sodium1 ,potassium1 ,iron1 ,manganese1 ,qu99 & ,/ry*n9740 ,an alcohol cont5t ( #ag p] c5t4 is decl>$ on ! label4 ,! foll[+ claims are typical ( ^? made = ! prep>ation3 8,?is grease1 or oil1 is n pres5t 9 ,wampole's ,prep>ation ( ! ,extract1 :i* is palatable &1 at ! same "t1 v effici5t z a /imulant to ! c5t]s ( nutrition & assimilation4 ,x is unsurpass$ z a recon/ructive tonic 4440 8,cases ) a m>k$ t5d5cy to pulmon>y tr\bles1444 if a timely impulse be giv5 !m w easily %ake (f ! imp5d+ evil4 ,wampole's ,prep>ation gives t timely impulse 4440 ,9 ! ,c\ncil's op9ion1 z previ\sly express$1#bj su* !rapeutic value z !re may be 9 cod liv] oil is *iefly1 if n altoge!r1 due to ! fat 7oil74 ,lately1 ! inve/igations ( ,j4 ,p4 ,/reet ( ! ,connecticut ,agricultural ,exp]im5t ,/ation h def9itely disprov$ ! claims made = ! ,wampole's & simil> prep>ations4 ,9 ,/reet's exp]im5ts1 rats 7 plac$ on a ration insuffici5t = normal nutrition & gr[?4 ,aft] ! rats _h be5 on ! ration = a "t long en\gh = inability to ma9ta9 weight to become evid5t1 dealcoholiz$ ,wampole prep>ation 0 sub/itut$ = a portion ( ! l>d conta9$ 9 ! ration4 ,lat] ! ,wampole prep>ation 0 replac$ by cod liv] oil4 ,f ^! exp]im5ts x appe>s t1 al?\gh ! ,wampole prep>ation is said to conta9 malt extract & sug>1 x does n %[ ! advantage ov] ord9>y cod liv] oil z a s\rce ( nutrim5t :i* is claim$ = x by ! manufactur]s4 ,/reet emphasizes t ! ,wampole prep>ation does n possess to any m>k$ degree ! recon/ructive prop]ties ( cod liv] oil1 butt] fat & egg yolk1 on :i* foods rats ga9 weight rapidly & /eadily aft] hav+ be5 on a defici5t diet4 ,/reet calls att5tion to ! fact t ! am\nt ( alcohol consum$ daily by ! us] ( ! ,wampole prep>ation 7! equival5t ( #j4g fluid\nces ( :iskey7 expla9s to a consid]able ext5t ! ass]t$ tonic virtues ( ! prep>ation4 #bj ,! ,j\rnal ,a4 ,m4 ,a41 ,oct4 #i1 #aiji1 p4 #abja4 7,see foll[+ report1 ?is volume47 ,?\gh (f]$ z an effici5t sub/itute = cod liv] oil1 ,wampole's 8,p]fect$ & ,ta/eless ,prep>ation ( an ,extract ( ,cod ,liv]0 lacks bo? ! nutritive & ! recon/ructive prop]ties & is m>ket$ "u an indef9ite "n & unw>rant$ & untrue claims4 ,x is recomm5d$ t ,wampole's ,prep>ation be held ineligible = ,new & ,non(ficial ,rem$ies4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,april #aj1 #aiae47 ,,wat]bury',s ,,metaboliz$ ,,cod-,,liv] ,,oil ,,comp\nd,k ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry & ,laboratory ,contribution on ,:i* ,x ,is ,bas$ ,k ,see also prec$+ reports on ,hagee's ,cordial & ,wampole's ,prep>ation2 also ,wat]bury's ,comp\nd once m1 p4 #bia2 ,! ,comp>ative ,nutri5t ,value ( ,cod ,liv] ,oil & ,cod ,liv] ,oil ,cordials1 p4 #dbb4 ,! foll[+ report has be5 adopt$ by ! ,c\ncil & its publication direct$ ,w4 ,a4 ,puckn]1 ,secret>y4 ,to ! ,c\ncil3--,y\r committee on ph>macology has read ) int]e/ ! contribution f ! ,association's laboratory on ,wat]bury's ,metaboliz$ ,cod-,liv] ,oil ,comp\nd4 ,! report %[s t mislead+ & false /atem5ts are made 9 reg>d to ! composition ( ! product & also t exagg]at$ & unw>rant$ claims are made = its !rapeutic value4 ,9 view ( ! attempt ( ! ,wat]bury ,*emical ,co4 to create a false impression 9 reg>d to ! !rapeutic value ( ! composition ( its product1 x is recomm5d$ t ! foll[+ report be adopt$ & publi%$3 ,! ,c\ncil believes t !re is a prepond]ance ( evid5ce to indicate t :atev] !rapeutic value cod-liv] oil has1 t value dep5ds *iefly1 if n entirely1 on its fat 7oil74 ,9 ! op9ion ( ! ,c\ncil1 ! ^w cod-liv] oil %\ld n be us$ 9 connection ) any prep>ation unless x consi/s to a l>ge ext5t 7#be p] c5t4 or m7 ( cod-liv] oil4 ,s9ce ,wat]bury's ,metaboliz$ ,cod-,liv] ,oil ,comp\nd conta9s no appreciable quantity ( cod-liv] oil1 ! "n is incorrect & mislead+1 & z a cod-liv] oil prep>ation x is believ$ to be :olly valueless4 ,! ,c\ncil has previ\sly vot$ t ,wat]bury's ,cod-,liv] ,oil ,comp\nd be refus$ recognition because ( conflict ) ,rules #a & #f4--7;,f ,! ,j\rnal ,a4 ,m4 ,a41 ,oct4 #i1 #aiji47 ,,contribution ,,f ,,! ,,*emical ,,laboratory ,,( ,,! ,,am]ican ,,m$ical ,,association ,wat]bury's ,metaboliz$ ,cod-,liv] ,oil ,comp\nd ,w4 ,a4 ,puckn] & ,l4 ,e4 ,w>r5 ,a full page adv]tisem5t ( ,wat]bury's ,metaboliz$ ,cod-,liv] ,oil ,comp\nd appe>$ 9 ! ,i[a ,m$ical ,j\rnal1 ,m>* #ae1 #aiji1 9 ! =m ( a lett] purport+ to give ! results ( an analysis ( ! product made = ! firm by a ,*icago *emi/4 ,9 ?is lett]-adv]tisem5t ! *emi/ /ates at ! outset t ! results ( 8 exam9ation 8are some:at at v>iance ) ! /atem5ts made 9 ,! ,j\rnal40 ,^! /atem5ts he quotes z foll[s3 #a4 ,x is a cle> liquid & no globules ( oil are se5 "u ! microscope4 ,x is !re=e n an emulsion4 #b4 ,x is ( acid reaction :5 mix$ ) wat] & rema9s cle> :5 /rongly acidifi$4 ,h5ce x does n conta9 a soap1 & is n a saponification ( fat4 #c4 ,x mixes ) wat] )\t precipitation1 h5ce1 x c n conta9 m ?an traces ( a fatty acid4 ,! *emi/ admits 9 8 lett] to ! firm t 8 analyses v]ify /atem5ts #a & #c1 b reg>d+ /atem5t #b he says3 8,i f9d t y\r prep>ation is acid 9 reaction1 b :5 /rongly acidifi$ gives a di/9ct turbidity )9 #aj m9utes & a volum9\s precipitate )9 #a h\r4 ,?is precipitate is %[n to consi/ ( fatty acids ( cod-liv] oil1 :i* are ?r[n d[n by ! splitt+ ( ! soaps1 on acidify+ ei!r ) sulphuric or hydro*loric acid40 ,f ^! results he /ates t to him x seems t ! 8prep>ation does n des]ve ! /atem5t t x conta9s no soap1 z !re is no "q :atev] ( ! pres5ce ( cod-liv] oil40 ,:ile 9 ! lett] publi%$ 9 ?is adv]tisem5t ! *emi/ claims to h demon/rat$ ! pres5ce 9 ! product ( 8saponifi$ cod-liv] oil10 he omits to m5tion ! quantities ( ! soap pres5t4 ,9 ! article t orig9ally appe>$ 9 ,! ,j\rnal 7,oct4 #ac1 #aijf71 9 addition to ! ?ree p>agraphs quot$ by ! *emi/1 ! foll[+ /atem5ts 7 made3 8,by ^! simple te/s a physician is easily able to demon/rate t ! prep>ation does n conta9 cod-liv] oil4 ,x is !re=e valueless = ! purpose ( nutrition = :i* we give ! oil4 ,m c>eful analysis confirms ! results ( ^! te/s & %[s t x conta9s no fat or fatty acids 7except ! m]e/ traces744440 ,at ! "t ^! /atem5ts 7 publi%$ 9 ,! ,j\rnal1 ! ,/4 ,paul ,m$ical ,j\rnal1 ,octob]1 #aijf1 conta9$ an adv]tisem5t = ,wat]bury's ,metaboliz$ ,cod-,liv] ,oil ,comp\nd1 :i* conta9$ ?is /atem5t3 8,! only ta/eless prep>ation on ! m>ket :i* conta9s ,cod-,liv] ,oil 9 its entirety4 ,! metaboliz$ product is obta9$ by ! action ( dige/ive f]m5ts on pure ,cod-,liv] ,oil40 ,9 ! ,ohio ,m$ical ,j\rnal ( ,feb4 #ae1 #aijg1 !re appe>$ 9 ! =m ( an adv]tisem5t :at purport$ to be an analysis ( ,wat]bury's ,metaboliz$ ,cod-,liv] ,oil ,comp\nd by ,pr(4 ,c4 ,n4 ,k9ney ( ,drake ,univ]sity4 ,:ile ,pr(essor ,k9ney made a quantitative analysis ( ! prep>ation1 ! quantities 7 omitt$ f ! analysis z publi%$4 ,a footnote add$ by ! ,wat]bury ,*emical ,company call$ att5tion to ?is fact & clos$ z foll[s3 8,any physician :o is n satisfi$ ) ! analysis we w be only too glad to furni% ! complete analysis by our repres5tatives40 ,if ?is weirdly con/ruct$ s5t5ce meant any?+1 x meant t ! complete analysis w\ld be furni%$ on reque/4 ,su* reque/s to ! company1 h[ev]1 f v>i\s s\rces fail$ to elicit ! in=mation requir$ nor 0 ! 8complete analysis0 =?com+4 ,! inf]5ce to be drawn is fairly pla94 ,9 a circul> accompany+ ! product z sold at pres5t1 ?is /atem5t occurs3 ---------------------------------------- -------- ,,wat]bury',s ,,metaboliz$ ,,cod ,,liv] ,,oil ,,comp\nd ,) ,creosote & ,guaiacol or ,pla9 ,,does ,,conta9 ,,cod ,,liv] ,,oil ,,does ,,allay ,,f]m5tation ,,does ,,aid ,,dige/ion ,,does ,,assi/ ,,assimilation ,,b ,,does ,,n ,,di/urb ,,! ,,/oma* ---------------------------------------- -------- ,z previ\s exam9ation disclos$ only ! m]e/ traces ( cod-liv] oil 9 ! product ?\gh claims 7 made t x 8repres5ts cod-liv] oil 9 its entirety10 & 9 view ( ! fact1 too1 t pres5t adv]tisem5ts emphatically decl>e t cod-liv] oil is pres5t 9 ! prep>ation z n[ sold1 x 0 ?\ght be/ to exam9e "s ( ! prep>ation ) especial ref]5ce to ! quantities ( fatty acids f cod-liv] oil4 ,illu/ration3 ,,old ,,label ,,new ,,label ,x is int]e/+ 9 ?is connection to note t ?is product is no long] be+ sold "u ! "n 8,metaboliz$ ,cod ,liv] ,oil ,comp\nd40 ,see ! illu/rations ( ! old & new labels4 ,! results ( ! exam9ation are briefly z foll[s3 ,! total quantity ( acids isolat$ am\nt$ to ab\t #j4c p] c5t41 & ( ?is am\nt ab\t two-?irds 0 salicylic acid4 ,?us x appe>s f ! exam9ation ( ! specim5s b\ght on ! op5 m>ket t ! prep>ation conta9s at mo/ b #j4a p] c5t4 ( ! fatty acids f cod-liv] oil1 a totally insignificant quantity4 ,not)/&+ ! prote/ations by ! manufactur]s1 9 ! =m ( publi%$ analyses & circul>s1 x is se5 t ! /atem5ts publi%$ 9 ,! ,j\rnal1 ,oct4 #ac1 #aijf1 p4 #abjg1 are ess5tially sub/antiat$2 x is fur!r evid5t t ! product does n des]ve to be designat$ z a cod-liv] oil prep>ation4 ,to obta9 a m$ic9al dose ( cod-liv] oil ! pati5t w\ld be compell$ to swall[ ! cont5ts ( a bottle ( ?is mixture1 & z ! product conta9s #aa p] c5t4 alcohol ! pati5t :o did s w\ld probably exp]i5ce a degree ( exhil>ation n ref]able to cod-liv] oil4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,oct4 #i1 #aiji47 ,decl>$ ,misbr&$ ,?is product ( ! ,wat]bury ,*emical ,company1 ( ,des ,mo9es1 ,i[a1 0 expos$ 9 ,! ,j\rnal ( ! ,am]ican ,m$ical ,association1 ,octob] #i1 #aiji4 ,9 ,may1 #aiaj1 ! ,unit$ ,/ates ,gov]nm5t issu$ a notice ( judgm5t 9 :i* x 0 decl>$ t ,wat]bury's ,metaboliz$ ,cod ,liv] ,oil ,comp\nd 0 misbr&$4 ,! c\rt r5d]$ its decree ( condemnation & =feiture4--,notice ( ,judgm5t1 ,no4 #cjc4 ,,wat]bury',s ,,comp\nd ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,wat]bury ,*emical ,company hav+ reque/$ t ! ,c\ncil reconsid] its action ( f\r ye>s ago 7see prec$+ report7 on ! product !n kn[n z ,wat]bury's ,cod-,liv] ,oil ,comp\nd1 n[ call$ ,wat]bury's ,comp\nd1 ! matt] 0 submitt$ to a ref]ee4 ,! ref]ee report$ t ! /atem5t n[ made z to ! composition ( ?is product is z foll[s3 8,made f ,cod ,liv] ,oil1 ,dige/ive ,f]m5ts1 ,malt ,extract ,unf]m5t$1 ,hypophosphites ,comp4 ,special1 ,ext4 ,*]ry1 ,eucalyptus1 ,aromatics1 etc40 ,he held t ! ,wat]bury ,*emical ,company has n submitt$ satisfactory evid5ce to indicate t ! objections ( ! ,c\ncil's =m] unfavorable report h be5 met2 t !re is no evid5ce t ! product is a sub/itute = cod-liv] oil 9 any way2 & t "u ! pres5t me?ods ( exploitation x con/itutes :at is at lea/ an inf]5tial fraud2 & recomm5d$ t no fur!r consid]ation be giv5 to ,wat]bury's ,comp\nd4 ,! report 0 adopt$ by ! ,c\ncil4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,m>* #bj1 #aiae47 ,,col*i-,,sal ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,col*i-,sal1 said to be made by ! ,anglo-,am]ican ,ph>maceutical ,co41 ,ltd41 ,new ,york1 is adv]tis$1 sold & 8gu>ante$0 7sic7 by ,e4 ,f\g]a & ,co41 ,inc41 ,new ,york4 ,accord+ to ! label ( a rec5tly pur*as$ specim53 8,ea* ,capsule conta9s ,cannabis ,indica 7,active ,pr9ciple (7 #a-ejj? ,gra9 7#a_/h ,milligram72 ,col*ic9e 7,cry/alliz$7 #a-bej? ,gra9 7#a_/d ,milligram72 ,me?yl ,salicylate #bj ,c5tigrams40 ,! adv]tis+ circul> ar\nd ! bottle adds t ! mixture also conta9s 8appropriate aromatic adjuvants40 ,x is recomm5d$ 9 8,g\ty & ,*ronic ,rheumatic ,manife/ations10 8acute cases ( ,g\t10 8inte/9al auto-intoxication or dyspepsia10 8bili\s heada*es10 etc4 ,salicylates are g5]ally recogniz$ z valuable 9 acute manife/ations ( acute articul> rheumatism2 col*icum is useless 9 ^! conditions4 ,bo? salicylates & col*icum are practically useless 9 *ronic rheumatic & 9 *ronic g\ty affections4 ,= dyspepsia1 bili\s heada*e1 etc41 salicylates are di/9ctly contra-indicat$ & ! dra/ic purgation produc$ by col*icum w\ld n be ?\ght desirable4 ,?\gh me?yl salicylate adm9i/]$ int]nally is n g5]ally consid]$ s effici5t z sodium salicylate1 x is ass]t$ t ! =m] 8444 is f\nd f> m effective ?an salicylate ( soda or o!r salicylic d]ivatives :5 giv5 9 conjunction ) col*ic9e z ,col*i-,sal40 ,fur!r1 ! highly improbable & unsub/antiat$ claim is made t 8! active pr9ciple ( ,cannabis indica0 7:atev] t may be7 8corrects any t5d5cy ( ! col*ic9e to irritate ! ga/ro-inte/9al tract0 & t ! 8appropriate aromatic adjuvants0 8prev5t intol]ance ( ! me?yl salicylate40 ,col*i-,sal is put up 9 a way to appeal to ! public2 ! bottle has ! "n 8,col*i-,sal0 bl[n 9 ! glass2 ! label gives full in/ruction = ! use ( ,col*i-,sal1 & also ! price1 sugge/+ t ! prep>ation may be freely pur*as$4 ,wrapp$ ar\nd ! bottle is a circul> advis+ its use 9 v>i\s affections4 ,! physician :o acts on ! advice t x is well to 8insi/ on ! ph>maci/ disp5s+ orig9al bottles 4440 ( ! 8little gre5 capsules0 actually sugge/s to 8 pati5t ! use ( ?is prep>ation ( me?yl salicylate & col*icum 9 conditions 9 :i* ^! drugs may d mu* h>m & 9 :i* prop] treatm5t is imp]ative4 ,col*i-,sal is typical ( unsci5tific ready-to-take propriet>ies4 ,x 0 held ineligible = ,new & ,non(ficial ,rem$ies because ( its secret composition1 viz41 ! unkn[n nature ( ! 8active pr9ciple ( ,cannabis indica0 7,rule #a72 because ! circul> 9 ! package & ! "n bl[n 9 ! bottle con/itute adv]tisem5t to ! laity 7,rule #d72 because ! claim t cannabis indica removes ! ga/ro-inte/9al irritation1 & ! claim ( ! sup]iority ( me?yl salicylate are unw>rant$ !rapeutic claims 7,rule #f72 because ! "n does n indicate ! pres5ce ( ! habit-=m+ cannabis indica1 & because ( its unsci5tific composition 7,rule #aj74--7;,f ,! ,j\rnal ,a4 ,m4 ,a41 ,m>* #bj1 #aiae47 ,,cypridol ,,capsules ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,hav+ vot$ t ,cypridol ,capsules be refus$ recognition1 ! ,c\ncil direct$ t = ! in=mation ( physicians publication ( ! foll[+ report be au?oriz$4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,cypridol ,capsules1 sold by ,e4 ,f\g]a ,co41 ,new ,york1 are /at$ to be 8,bottl$ 9 ! ,new ,york ,laboratories ( ,vial1 late ,rigaud & ,*apoteaut1 ,p>is10 & to conta91 9 ea* capsule1 #b mg4 7#a_/cb gra97 m]curic iodid 7b9iodid ( m]cury7 dissolv$ 9 a fatty oil4 ,!y are claim$ to p]mit ! adm9i/ration ( m]cury )\t dang] ( salivation--an obvi\s misrepres5tation4#ba ,cypridol ,capsules are m>ket$ 9 a way to appeal to ! public4 ,if !y are once prescrib$1 ! directions on ! bottle & ! full in/ructions = ! treatm5t ( syphilis by means ( ,cypridol & by o!r propriet>ies sold by ,f\g]a ,co4 is likely to lead ! pati5t to attempt ! treatm5t ( ?is malady on 8 own accord1 & ?us probably to =feit 8 *ances ( cure4 ,cypridol is a vici\s example ( ! 8ready-to-take0 propriet>ies4 #ba ,physicians :o desire to use a solution ( m]curic iodid 9 oil %\ld direct _! ph>maci/ to prep>e x accord+ to ! me?od sugge/$ by ,lemaire 7,rep]t4 ph>m41 xxi1 #ig-ajb1 f ,*em4 ,ab/41 #aiji1 p4 #addd71 viz43 ,"o gm4 ( m]curic iodid is dissolv$ 9 #ej c4c4 /]iliz$ ca/or oil by w>m+ to ab\t #gj degrees1 #c gm4 guaiacol are add$ & ! solution made up to #ajj c4c4 ) /]iliz$ poppy oil4 ,or accord+ to a lat] sugge/ion 7,dunn+3 ,proc4 ,am4 ,ph>m4 ,assn41 #aiaj1 p4 #aabc73 "o gm4 ( m]curic iodid is dissolv$ 9 #ii gm4 ( a mixture ( equal p>ts ( /]iliz$ ca/or & olive oils1 by w>m+ on ! wat]-ba?4 ,cypridol ,capsules are 9 conflict ) ! rules ( ! ,c\ncil z foll[s3 ,rule #d3 ,! dosage1 price1 etc41 on ! label1 & ! "n 8,cypridol0 bl[n 9 ! bottle1 all t5d to a direct self-prescrib+ by ! public4 ,9 addition to ! objectionable /atem5ts on ! bottle itself1 ! prep>ation is put up 9 pat5t m$ic9e /yle & is accompani$ by a circul> giv+ full directions = ! use ( ?is & ( o!r propriet>ies = ! treatm5t ( syphilis 9 all ( its /ages4 ,! circul> /ates t 8a #a p] c5t4 solution ( b9-iodide ( m]cury 9 an aseptic oil0 is 8,an ,improv$ ,specific 9 ! ,treatm5t ( ,syphilis10 & aft] laud+ ! virtues ( ,cypridol1 gives full directions = ! treatm5t ( syphilis 9 its v>i\s /ages by means ( ,capsules ( ,cypridol augm5t$1 dur+ p]iodical cessation ( treatm5t1 by 8small doses ( iodide ( /rontium 7,p>af-,javal's /&>d solution1 ?irty gra9s to ! ounce740 ,fur!r1 ! circul> exp\nds ! ne$ ( 8a ton+ up ( ! g5]al sy/em0 & by means ( obsolete !ories & obvi\sly untrue ass]tions recomm5ds 8,*apoteaut's ,w9e ano!r ( _! propriet>y prep>ations1 ea* ounce ( :i* conta9s #aj gra9s ( phospho-glyc]ate ( lime4 ,?is is a delici\s1 nutritive tonic4 ,a p9t bottle co/s #a4jj40 ,rule #f3 ,:]eas x is evid5t t ,cypridol1 dep5d+ = its effects on m]curic iodid1 ! ord9>y well-kn[n hydr>gyri iodidum rubrum ( ! ,u4 ,s4 ,ph>macopeia1 mu/ naturally h ! prop]ties ( a m]curic comp\nd1 unw>rant$ claims su* z ! foll[+ are made3 8,,cypridol does n r5d] pati5ts anemic4 ,ptyalism nev] foll[s ! adm9i/ration ( ! capsules or injections4 ,on ! contr>y1 pati5ts rapidly put on fle% & keep well4 ,!re are no di>rhoeas or o!r symptoms ( intol]ance ev5 :5 ! dose is pu%$40 ,rule #h3 ,! non-in=m+ "n 8,cypridol0 = a m]curic iodid prep>ation is b\nd to lead to its use )\t consid]ation ( ! fact t a pot5t m]cury prep>ation is be+ us$1 requir+ a c>eful adju/m5t ( dosage1 a consid]ation ( ! ne$s ( ! individual case1 a correct diagnosis1 etc4 ,:ile ! adv]tis+ propag&a argues t 8physicians recognize ! advantage ( prescrib+ ?is solution ( m]curic iodide 9 an aseptic oil "u ! "n ( #8,cypridol1' because x does n betray to ! laity ! fact t m]cury is be+ us$10 n only ! physician b also ! pati5t has a "r to "k1 & ought to "k1 ! pot5t "* ( ! rem$y :i* is be+ adm9i/]$4 ,x is recomm5d$ t ,cypridol be refus$ recognition & t publication ( ?is report be au?oriz$4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,dec4 #ai1 #aiad47 ,,cy/og51 ,,cy/og5 ,,ap]i5t ,,& ,,cy/og5-,,li?ia,l ,ab/ract ( ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,l ,= ! unabridg$ report ( ! ,c\ncil's action on ,cy/og51 ,cy/og5 ,ap]i5t & ,cy/og5-,li?ia1 see ,reports ,c\ncil ,ph>m4 & ,*em41 #aiad1 p4 #ff4 ,cy/og5 is ! !rapeutically sugge/ive "n appli$ to hexame?yl5am9 by ! ,cy/og5 ,*emical ,company4 ,:ile inve/igation has %[n t hexame?yl5am9 yields =maldehyd only 9 ! pres5ce ( an acid & consequ5tly c produce an antiseptic effect only 9 ! ga/ric juice & 9 ! ur9e1 x is claim$ t ,cy/og5 is an 8inte/9al antiseptic0 & t x 8be>s its dis9fectant & antitoxic qualities into well-nigh e important bodily cavity40 ,z ! sale ( a simple drug ev5 ) ! aid ( ! mo/ extravagant claims probably did n (f] suffici5t opportunity = an ext5sive propriet>y propag&a1 ! ,cy/og5 ,company has put out two o!r prep>ations1 ,cy/og5 ,ap]i5t & ,cy/og5-,li?ia1 & f9ds x an easy matt] by means ( extravagant claims1 unw>rant$ ass]tions & pseudo-sci5tific argum5ts to recomm5d ! use ( "o or ano!r1 or (t5 all ?ree1 9 a well-nigh endless numb] ( diseases4 ,z ! cont9u$ patronage ( ! m$ical pr(ession _c be reli$ on = propriet>ies ( ?is sort1 ! ,cy/og5 ,*emical ,company takes good c>e t e ,cy/og5 prescription is likely to spread ! ,cy/og5 gospel among ! p4 ,! ,c\ncil has direct$ publication ( its report on ! ,cy/og5 products to call att5tion to ! way 9 :i* a simple drug ( e/abli%$ value may be made ! basis ( an ext5sive propriet>y propag&a4 ,a cons]vative discussion ( ! action ( hexame?yl5am9 appe>s 9 ! ,c\ncil's publication1 8,useful ,drugs40 ,! ,c\ncil !re=e refus$ recognition to ,cy/og51 ,cy/og5 ,ap]i5t & ,cy/og5-,li?ia4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,dec4 #ab1 #aiad47 ,,cy/o-,,s$ative ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,cy/o-,s$ative is sold by ,/rong1 ,cobb & ,company1 ,clevel&1 ,ohio1 ) ! claim3 8,ea* fluid ounce repres5ts3 ,?uja ,occid5talis1 #c-a_/b gra9s4 ,pi*i1 #ah grs4 ,saw ,palmetto b]ries1 #cf grs4 ,triticum ,rep5s1 #cf grs4 ,hyoscyamus #h grs4 ,all in]t extractive matt] be+ elim9at$40 ,! !rapeutically active con/itu5ts ( arbor vit1 pi*i1 saw palmetto & c\* grass h nev] be5 isolat$--inde$1 x has n be5 prov$ t all ( ^! drugs conta9 any !rapeutically active con/itu5ts4 ,yet ! absurd claims are made t all in]t matt] has be5 elim9at$ & ea* lot ( drug us$ 9 ! prep>ation ( ,cy/o-,s$ative is 8te/$ 9 ref]5ce to its m$ic9al activity40 ,equally prepo/]\s is ! claim3 8,9 =mulat+ ,cy/o-,s$ative ea* drug ent]+ into its composition 0 subject$ to c>eful /udy cl9ically to det]m9e ! exact proportion requir$ :5 comb9$ to increase _! effici5cy z a :ole4 ,cy/o-,s$ative is sci5tifically prep>$1 ! proportion ( ea* individual drug be+ s f9ely adju/$ z to increase _! !rapeutic action 9 ! conditions = :i* !y are int5d$1 =m+ a prep>ation always reliable & ( ! v highe/ m$ic9al activity40 ,"s o!r extravagant claims made = ?is complex unsci5tific mixture are3 8,x gives relief 9 almo/ e =m ( cy/itis & pro/atitis44440 8,! be/ results are obta9$ 9 ! wor/ *ronic cases ( cy/itis & pro/atitis44440 8,9 ,cy/itis1 ,ure?ritis1 ,pro/atitis1 ,inflammation ( ! ,vesicle ,neck1 complicat$ ) ,gonorrhoea1 ,enuresis1 ,pa9ful ,micturition1 ! action ( ,cy/o-,s$ative is prompt40 ,! ,c\ncil vot$ t ,cy/o-,s$ative be refus$ recognition4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,dec4 #ab1 #aiad47 ,,taka-,,dia/ase ,,& ,,liquid ,,taka-,,dia/ase ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,"s "t ago x 0 decid$ t a reexam9ation %\ld be made ( ,taka-,dia/ase & ,liquid ,taka-,dia/ase1 bo? ( :i* _h previ\sly be5 reject$1 to asc]ta9 :e!r or n ! prep>ations 7 9 accord ) ! claims made = !m by ! manufactur]s4 ,accord+ly1 ! matt] 0 ref]r$ to a committee ( ! ,c\ncil1 & an exam9ation ( specim5s ( ^! two prep>ations b\ght 9 ! m>ket 0 made4 ,! ref]ee's report1 :i* appe>s bel[1 accord+ to ! usual proc$ure1 & be=e f9al confirmation by ! ,c\ncil1 0 fir/ submitt$ to ! manufactur]s ( ,taka-,dia/ase = comm5t4 ,! report recomm5ds t ! rejection ( ,taka-,dia/ase & ,liquid ,taka-,dia/ase be all[$ to /&1 & t ! report be publi%$4 ,p>ke1 ,davis ,co41 9 _! reply1 :i* is giv5 9 full bel[1 claim t ! report is unju/ conc]n+ ,liquid ,taka-,dia/ase1 because ! p]iod ( activity ( ! prep>ation has be5 greatly prolong$ by r$uc+ ! am\nt ( alcohol f #ah p] c5t4 to #aj p] c5t4 & by add+ glyc]94 ,!y reit]ate _! claims = ! dige/ive p[] ( ,taka-,dia/ase1 b admit t x w n r$uce ! /at$ am\nt ( />* to ! colorless end-po9t 9 t5 m9utes 7! /&>d me?od = ! valuation ( dia/ase74 ,!y fur!r /ate t !y w\ld *ange ! ^w 8dige/0 on ! label to 8liquefy40 ,! conclusion ( ! report hav+ be5 que/ion$1 ! entire matt] 0 ref]r$ to a memb] ( ! ,c\ncil's /aff ( cl9ical consultants4 ,8 report1 :i*1 also1 is giv5 9 full bel[1 /ates t ! mat]ial be=e him 0 suffici5t to decide ! matt]1 & no fur!r te/s 7 necess>y4 ,he concludes t ! claims ( ! manufactur]s reg>d+ ! /r5g? & prop]ties ( ! mat]ial are errone\s & exagg]at$2 t ! lit]ature /ill s5t out by ,p>ke1 ,davis ,co4 is mislead+2 & t if sub/itution ( ! ^w 8liquefy0 = 8dige/0 7 endors$ by ! ,c\ncil confusion w\ld result :i* w\ld give an exagg]at$ & false value to ,taka-,dia/ase4 ,he !re=e recomm5ds t ! report ( ! re9ve/igation ( ,taka-,dia/ase be accept$ by ! ,c\ncil & publi%$4 ,?is report ( ! second ref]ee 0 ref]r$ to ,p>ke1 ,davis ,co4 ) ! reque/ t !y /ate m def9itely ! actual amylolytic /r5g? ( _! prep>ations4 ,to ?is !y repli$ t !y _h no desire to discuss ! subject fur!r1 or to make any additional /atem5ts4 ,9 accordance ) ! second ref]ee's recomm5dations1 ! ,c\ncil confirm$ its provisional action & vot$ t ! rejection ( ,taka-,dia/ase & ,liquid ,taka-,dia/ase be all[$ to /&1 & t ! report :i* appe>s bel[ be au?oriz$ = publication4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,,ref]ee',s ,,report ,,on ,,taka-,,dia/ase ,,& ,,liquid ,,taka-,,dia/ase ,foll[+ is ! report ( ! committee to :i* 0 ref]r$ ! reexam9ation ( ,taka-,dia/ase & ,liquid ,taka-,dia/ase3 ,"s "t ago a comp>ison 0 made ( ! v>i\s me?ods propos$ = ! valuation ( prep>ations claim$ to h amylolytic p[]4 ,?is "w 0 report$ 9 ,! ,j\rnal1#bb & ! me?od propos$ = ! te/+ ( dia/ase prep>ations n[ appe>s 9 ,new & ,non(ficial ,rem$ies4#bc ,9 view ( ! incorrect & exagg]at$ claims made = ,taka-,dia/ase1 ! ,c\ncil 9 #aijh 0 oblig$ to resc9d its acceptance & to direct its omission f ,new & ,non(ficial ,rem$ies4 ,! report conta9$ ! foll[+ ref]5ce to ,taka-,dia/ase 7,p>ke1 ,davis ,company71 a product t _h be5 accept$ = inclusion ) ,new & ,non(ficial ,rem$ies3 #bb ,! ,j\rnal ,a4 ,m4 ,a41 ,july #aa1 #aijh1 p4 #adj4 #bc ,new & ,non(ficial ,rem$ies1 #aiab1 p4 #fh2 ,! ,j\rnal ,a4 ,m4 ,a41 ,april #ae1 #aiaa1 ,"p #b1 p4 #ah4 8,! wide/ discrepancy betwe5 ! values z claim$ by ! manufactur] & ^? f\nd by actual te/s seems to be %[n 9 ! case ( ,taka-,dia/ase4 ,! liquid prep>ation has be5 te/$ a numb] ( times 9 diff]5t samples & has always be5 f\nd weak4 ,"s samples1 9 fact1 7 q in]t4 ,?is f]m5t appe>s to lose /r5g? v rapidly 9 solution1 z ! manufactur]s n[ conc$e4 ,! /ability ( ! solid product is also f> f satisfactory1 & appe>s to be less ?an t ( ! f]m5t z m>ket$ "s ye>s ago4 ,! two samples exam9$ rec5tly 7 weak40 ,m ?an ?ree ye>s h n[ elaps$ s9ce ! publication ( ! ,c\ncil's f9d+s reg>d+ ,taka-,dia/ase--suffici5t "t1 x is believ$1 = ! manufactur]s to modify ei!r _! claims or ! product itself1 & ?us aga9 make x eligible = inclusion ) ,new & ,non(ficial ,rem$ies4 ,) ?is idea 9 m9d new specim5s ( ,taka-,dia/ase & ,liquid ,taka-,dia/ase 7 pur*as$ f a ,*icago drug h\se & ! prep>ations re9ve/igat$4 ,! foll[+ is ! report ( ?is re9ve/igation4 ,,report ,,( ,,! ,,reexam9ation ,9 our report on ! dia/ase prep>ations ?ree ye>s ago1 x 0 recomm5d$ t ,taka-,dia/ase be remov$ f ,new & ,non(ficial ,rem$ies1 because ! exam9ations %[$ t x did n h ! dige/ive /r5g? claim$ = x4 ,?is 0 true bo? = ,taka-,dia/ase itself & = ,liquid ,taka-,dia/ase4 ,s f> z ! latt] 0 conc]n$1 ! />*-conv]t+ p[] 0 practically nil 9 ^? prep>ations :i* _h be5 9 ! drug /ores = "s mon?s4 ,dur+ ! la/ few weeks new te/s h be5 c>ri$ out ) sev]al samples ( ! ,taka-,dia/ase prep>ations & ! results obta9$ are ess5tially ! same z ^? obta9$ 9 ! =m] exam9ations4 ,! liquid prep>ation is /ill extremely weak 9 />*-conv]t+ p[]1 :ile we f\nd t ,taka-,dia/ase itself w\ld conv]t only #af4f p>ts ( pure anhydr\s />* to ! colorless end-po9t 9 t5 m9utes1 z expla9$ bel[4 ,9 our me?od ( exp]im5tation we det]m9e ! weight ( ! dia/ase 9 "q :i* w conv]t a giv5 weight ( />* 9 uni=m pa/e to ! s-call$ colorless end-po9t 9 t5 m9utes1 t is to ! po9t :]e x w no long] give any color reaction ) a /&>d iod9 solution4 ,! /&>d />* weight 9 #ej c4c4 always is #a gm4 or #a1jjj mg4 & to a s]ies ( flasks conta9+ ?is am\nt ( />*1 ma9ta9$ at a con/ant temp]ature ( #dj ,c41 ! dia/ase dilutions are add$4 ,^! dia/ase dilutions are made by dissolv+ small1 accurately weigh$ am\nts ( ! sample 9 "s small1 con/ant volume ( wat]1 usually #e or #aj c4c4 & !y are !n p\r$ into ! />* flasks at ! "r temp]ature1 & agitat$ regul>ly4 ,te/s are made by tak+ a few drops f ea* flask & mix+ ) ! iod9 solution4 ,! end-po9t is rea*$ :5 a dilution is f\nd :i*1 at t5 m9utes f ! mix+ "t1 gives no color ) ! iod9 reag5t4 ,! fir/ set ( te/s is tak5 z a g5]al guide1 & q accurate results may be obta9$ 9 a second set ( dilutions4 ,we fir/ us$ a sample ( ,taka-,dia/ase b\ght 9 ! op5 m>ket4 ,x 0 f\nd t #adj mg4 7 requir$ to conv]t ! gram ( />* z expla9$4 ,?is is equival5t to a conv]sion ( #g4ad p>ts ( />* by #a "p ( ! ,taka-,dia/ase4 ,a new1 & possibly fre%]1 sample 0 !n obta9$ & ! te/ repeat$4 ,) ?is new sample x 0 f\nd t #fj mg4 7 necess>y to conv]t ! gram ( />* to ! colorless end-po9t 9 t5 m9utes1 f :i* x foll[s t #a "p ( ! f]m5t w conv]t #af4f p>ts ( />* to ! colorless end-po9t 9 ! same "t4 ,) a new sample ( ,liquid ,taka-,dia/ase obta9$ simultane\sly x 0 f\nd t #c4e c4c4 7 necess>y to conv]t #a gram ( />* to ! colorless end-po9t 9 t5 m9utes4 ,z a fluid\nce ( ?is liquid is said to conta9 #bj gra9s ( ! solid x w be se5 t ! results approximately agree ) ^? ( ! fir/ sample ( ! solid1 & t !y are bo? v l[4 ,9 ! e>li] te/s #af p>ts ( />* conv]t$ by #a "p ( ! f]m5t 0 ! value f\nd4 ,^! results are 9 close agreem5t ) values report$ by ,%]man 7,j\r4 ,am4 ,*em4 ,soc41 xxxii1 #ajgc7 = a sample ( rec5t pur*ase4 ,he f\nd a conv]sion ( #ea p>ts ( />* to ! colorless end-po9t 9 ?irty m9utes = "o sample1 :ile = ano!r he f\nd #ff p>ts1 9 ! same "t4 ,x w be not$ t our "t limit is t5 m9utes4 ,x is wor?y ( note t = a p]fectly fre% & specially prep>$ sample furni%$ by ,dr4 ,takam9e1 a conv]sion ( #bgh p>ts 9 ?irty m9utes 0 f\nd by ,%]man4 ,tak+ ! "t into consid]ation1 x w be se5 t ! results are ab\t ! same = ! m>ket samples z ^? f\nd by u & mu* l[] ?an claim$1 z well z mu* l[] ?an = o!r makes ( simil> products4 ,! diff]5ce 9 ! behavior ( fre% specially prep>$ ,taka-,dia/ase & ! m>ket sample is v cle>ly %[n4 ,no "o que/ions ! fact t fre% laboratory samples ( ,taka-,dia/ase may %[ a mod]ate conv]t+ p[] on />*4 ,b we h to deal ) ! activity ( m>ket samples only1 & ,%]man's "w & our own %[ ! l[ dige/+ p[] ( ! product z physicians may secure x on ! m>ket4 ,! m>k$ diff]5ce 9 activity betwe5 p]fectly fre% & ord9>y m>ket samples ( ,taka-,dia/ase is v cle>ly %[n also 9 a rec5t pap] publi%$ by ,wohlgemu?4#bd ,9 ! dige/ion ( />* pa/e to ! 8dextr90 /age ,wohlgemu? f\nd 9 ! comm]cial sample a /r5g? approximately a hundr$ times less ?an t obs]v$ 9 a fre% sample s5t him by ,dr4 ,takam9e4 #bd ,wohlgemu?3 ,bio*em4 ,zts*r41 ,m>* #ah1 #aiab4 ,wohlgemu?'s results 7 obta9$ by a me?od n ess5tially diff]5t f ours1 ) ?is diff]5ce1 h[ev]1 t he dige/$ ?r\gh #bd h\rs 9 ! cases report$1 & c>ri$ ! reaction to ! 8dextr90 /age only1 9 place ( to a colorless end-po9t4 ,mak+ ! prop] r$uctions1 x is evid5t t ! actual values f\nd by him = ! m>ket samples b\ght 9 ,g]many are n great] ?an ^? report$ by u4 ,! ref]5ce to ! "w ( ,%]man is made because1 9 a foll[+ pap] 9 ! same j\rnal1 he recomm5ds ! use ( salt z an activator 9 f9d+ ! /r5g? ( c]ta9 dia/ase prep>ations4 ,x is well kn[n t dialyz$ dia/ase prep>ations & />* ( highe/ purity h b slight action on ea* o!r2 a little salt increases ! activity greatly1 & also increases ! activity ( comm]cial dia/ase prep>ations4 ,^! facts ,%]man utilizes 9 work+ out a me?od = valuation ( comm]cial dia/ases4 ,! facts 7 well kn[n to u at ! "t ( our =m] report1 b x 0 n ?\ght be/ to dep>t f ! g5]al me?od :i* _h be5 9 use by all analy/s foll[+ ! g5]al s*eme ( ,rob]ts4 ,q rec5tly1 ,i4 ,bang has publi%$ a pap] on ! inve/igation ( dia/ase 7,bio*em4 ,zts*r41 xxxii1 #dag7 9 :i* he /udies ! behavior ( sodium *lorid & o!r salts on ! rapidity ( />* conv]sion1 & f9ds t a mu* small] am\nt ( salt ?an ,%]man recomm5ds br+s ! maximum increase4 ,! me?od employ$ 9 our =m] te/s is a good comp>ative me?od1 & ?is is all t may be claim$ at pres5t = any me?od4 ,by add+ salt to our />* solution ! activity ( ,panase & o!r f]m5ts is likewise greatly increas$4 ,= ,panase1 a prep>ation possess+ r high />*-conv]t+ p[]1 we h rec5tly f\nd an increase ( ab\t #cj p] c5t4 9 ! conv]t+ p[]1 ) salt pres5t4 ,work+ to loss ( blue color1 m]ely1 x is possible 9 ?is way to get a high] value ?an t claim$ by ! manufactur]4 ,!re is no practical ga9 9 us+ ! salt = our purpose z ! me?ods are at be/ arbitr>y1 & ! results only comp>ative4 ,tak+ all ! facts into consid]ation1 x is recomm5d$ t ! rejection ( ,taka-,dia/ase & ,liquid ,taka-,dia/ase be all[$ to /& & t1 9 view ( _! ext5sive exploitation1 ?is report be au?oriz$ = publication s t physicians may "k ! facts4 ,?is report 0 ref]r$ to ,p>ke1 ,davis ,co41 & !y made ! foll[+ reply3 8,! report submitt$ 9 y\r lett] ( ! #bc;d is1 we cont5d1 errone\s & unju/3 fir/1 to our ,liquid ,taka-,dia/ase1 because ov] ?ree ye>s ago we *ang$ our =mula1 r$uc+ ! alcohol f #ah p] c5t4 to #aj p] c5t41 increas+ ! glyc]9 & ?us prolong+ greatly ! p]iod ( activity4 8,z = our regul> ,taka-,dia/ase1 our claim is & has be5 = ye>s simply t ,taka-,dia/ase w dige/ or hydrolyze #aej times its weight ( />* 9 t5 m9utes1 "u prop] conditions4 ,we d n claim1 we d n p]mit our repres5tatives to claim1 t ,taka-,dia/ase w completely trans=m />*1 to ! colorless end-po9t1 into sug>s4 ,taka-,dia/ase is us$ to supplem5t a defici5cy ( ptyal9 & conv]ts ! />* into soluble mat]ial ) great rapidity1 ?us giv+ ! ga/ric fluid imm$iate access to ! proteids4 8,if 9 ! enclos$ labels ! ^w #8dige/' 7 replac$ ) ! ^w #8liquefy1' ! claim c\ld n be assail$ by ! mo/ c>p+ critic4 ,to save any possible "q1 we %all !re=e make ?is *ange 9 our label1 hav+ x read3 #8,taka-,dia/ase w liquefy #aej times its weight ( />* 9 t5 m9utes1 "u prop] conditions4' ,is !re ! slighte/ "q 9 y\r m9d t ?is /atem5t z j quot$ is entirely correct & entirely support$ by cl9ical exp]i5ce8 8,x is our conviction t ,taka-,dia/ase has a v rem>kable p[] to hydrolyze />* ei!r 9 ! te/-tube or 9 ! /oma*1 & t ?is prop]ty is ( great utility 9 cl9ical "w4 ,we d n claim t its conv]sion ( ! />* into sug>s is complete1 to ! colorless end-po9t ( ! ,johnson te/2 & on ?is po9t we h be5 p]fectly frank ) ! ,c\ncil1 z well z ) e physician :o has tak5 suffici5t int]e/ to inquire40 ,9 view ( ! above prote/1 ! matt] 0 submitt$ to a second ref]ee1 :o report$ z foll[s3 8,y\r ref]ee on ! matt] ( ,taka-,dia/ase has made a c>eful inve/igation ( ! reports & correspond5ce submitt$1 & begs to make ! foll[+ report3 8,! "q at issue1 viz41 :e!r ,taka-,dia/ase %\ld be includ$ 9 ,new & ,non(ficial ,rem$ies1 ,i believe1 c be det]m9$ by ! mat]ial be=e me1 & fur!r te/s ( ! mat]ial are n necess>y4 8,! lett] ( ! mak]s ( ,taka-,dia/ase admits t ! e>ly claims reg>d+ ! /r5g? & prop]ties ( ! mat]ial 7 errone\s & exagg]at$4 ,s9ce ! product 0 once admitt$ to ,new & ,non(ficial ,rem$ies1 x may be claim$ t z ! ,c\ncil on ,ph>macy & ,*emi/ry mu/ h be5 9 error !n1 x may be n[4 ,y\r ref]ee does n consid] ?is supposition wor? discuss+4 ,! conclusion he draws is t ! ,c\ncil 0 too ha/y 9 accept+ ! prep>ation1 & t ! incid5t %[s h[ mu* bett] x w\ld be 9 all cases to accept no rem$y until suffici5t "t has be5 giv5 = conclusive te/s4 8,! lit]ature /ill s5t out by ,p>ke1 ,davis ,co4 reg>d+ ,taka-,dia/ase is mislead+ & ( a k9d m appropriate = a no/rum ?an a /&>d *emical sub/ance4 ,:at w\ld we ?9k if morph91 qu99 or ev5 h]o9 7 adv]tis$ 9 ! same way8 ,i cite ! /atem5t1 #8,taka-,dia/ase dige/s />*y food ) vigor & directness4' ,x seems to ! ref]ee t ! proposition to modify ! label to indicate ! am\nt ( />* :i* is liquefi$ r ?an ! am\nt :i* is sac*>ifi$1 9 accordance ) ! ,c\ncil's /&>d1 is b\nd to lead to confusion & to give an exagg]at$ & false value to ,taka-,dia/ase4 8,y\r ref]ee recomm5ds t ! report ( ! re9ve/igation ( ,taka-,dia/ase :i* has be5 submitt$ to me1 be made available to ! m$ical pr(ession1 & t ! rejection ( ,taka-,dia/ase & ,liquid ,taka-,dia/ase be all[$ to /&40 ,?is report ( ! second ref]ee 0 submitt$ to ,p>ke1 ,davis ,co41 ) ! reque/ t !y /ate m explicitly _! claims reg>d+ ! activity ( ,taka-,dia/ase & ,liquid ,taka-,dia/ase1 9 ord] t1 if !y decid$ to revise _! claims = ! prep>ations1 su* revision ( claims might be publi%$ along ) ! reports ( ! ,c\ncil4 ,!y repli$3 8,answ]+ y\r note ( ! #ae? in/ant3 ,we h no desire to discuss fur!r ! subject ( y\r lett] ( ,febru>y #bd1 or to make any /atem5t beyond t set =? 9 our lett] to y ( ,dec4 #bg1 #aiaa40--7;,f ,! ,j\rnal ,a4 ,m4 ,a41 ,july #f1 #aiab47 ,,digal5 ,,omitt$ ,,f ,n4 ,n4 ,r4 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,digal5 is a propriet>y said to conta9 a soluble =m 7digitox9um solubile ,cloetta7 ( digitox91 ! *ief active pr9ciple ( digitalis4 ,?is prep>ation 0 accept$#be by ! ,c\ncil 9 #aiji = inclusion 9 ,new & ,non(ficial ,rem$ies4 ,! ,c\ncil _h n at t "t det]m9$ :e!r ,digal5 conta9$ 8soluble amorph\s digitox910 z claim$1 or n4 ,! product 0 accept$ m]ely z a /&>diz$ soluble & fairly /able digitalis prep>ation4 #be ,! ,j\rnal ,a4 ,m4 ,a41 ,sept4 #aa1 #aiji1 p4 #hfi4 ,aft] ! acceptance ( ,digal51 ! !rapeutic claims made = x by ! manufactur]s increas$ 9 extravagance4 ,mean:ile1 evid5ce 0 br\ght =w>d by v>i\s indep5d5t inve/igators :i* t5d$ n only to %[ t ^! !rapeutic claims 7 unf\nd$1 b also to discr$it ! claim t ,digal5 conta9$ a pr9ciple *emically id5tical ) digitox94 ,9 view ( ! obscurity ( ! :ole subject ( ! *emi/ry ( ! digitalis pr9ciples1 ! latt] claim 7t ,digal5 0 a solution ( 8amorph\s digitox907 _h be5 an academic issue at ! "t ( ! acceptance ( ! product4 ,:51 h[ev]1 ! manufactur]s ( ,digal5 s\ght to mislead physicians by increas$ & unw>rant$ !rapeutic claims1 ! ,c\ncil felt t inve/igation ( ! :ole matt] 0 imp]atively dem&$ to decide :e!r or n ,digal5 %\ld be reta9$ 9 ,n4 ,n4 ,r4 ,! que/ions at issue 73 7#a7 ! pres5ce 9 ,digal5 ( 8amorph\s digitox902 7#b7 ! con/ancy ( composition & reliability ( action ( ,digal51 & 7#c7 ! claim t x causes less ga/ric di/urbance ?an digitox94 ,no satisfactory pro( has yet be5 (f]$ t ,digal5 conta9s 8amorph\s digitox940 ,! mass ( evid5ce t5ds to %[ t ,digal5 is n con/ant 9 composition or reliable 9 action1 & t1 :5 giv5 9 doses correspond+ 9 !rapeutic activity1 ,digal5 causes q z mu* ga/ric di/urbance z ! (ficial gal5ical prep>ations ( digitalis4 ,! outcome ( protract$ negotiations betwe5 ! ,c\ncil & ! ,h(fmann-,la ,ro*e ,*emical ,works may be summ$ up z foll[s3 #a4 ,! manufactur]s promise to hold 9 abeyance ! claim reg>d+ ! pres5ce ( 8amorph\s digitox940 #b4 ,!y refuse to conc$e ! v>iable composition ( ,digal54 #c4 ,!y reass]t ! claim t ,digal5 is sup]ior to o!r digitalis products ) respect to liability to cause ga/ric irritation & consequ5t vomit+4 ,9 view ( ! unsatisfactory "* ( ! reply on ! second & ?ird po9ts1 ! ,c\ncil vot$ t ,digal5 be omitt$ f ,n4 ,n4 ,r4 & t publication ( ! report on ,digal5 :i* appe>s bel[ be au?oriz$1 z well z ( ! two reports#bf 7,a & ,b7 ref]r$ to !re94 #bf ,^! reports 7,a1 fir/ report on ,digal5 & ,b1 exam9ation ( ,digal5 ,tablets7 w be publi%$ 9 ! #aiad ,annual ,c\ncil ,reports4 ,a repr9t ( ! entire matt] deal+ ) ! rejection ( ,digal5 w be s5t on receipt ( a two-c5t /amp4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,ref]ee's ,report on ,digal5 ,because ( p]si/5t conflict ) ,rule #f 7unw>rant$ !rapeutic claims7 & ,rule #a 7composition7 x is recomm5d$ t ,digal5 be omitt$ f ,new & ,non(ficial ,rem$ies2 also t a copy ( ! report be s5t to ! manufactur]s1 & t publication ( ?is report & ! two previ\s reports submitt$ to ! ,c\ncil be au?oriz$4 ,! nature ( ! problems involv$ necessitates a some:at ext5d$ discussion ( ! subject4 ,digale9 7liquid7 is said to conta9 #a "p ( soluble amorph\s digitox9 ,cloetta 9 #a1jjj p>ts ( glyc]9 & #a1fjj p>ts ( wat] ) #g4e p] c5t4 ( alcohol4 ,"o c4c4 is said to conta9 #j4jjjc gm4 ( ! amorph\s digitox94 ,digal5 0 accept$ by ! ,c\ncil#bg & ! foll[+ footnote 0 app5d$ to ! description 9 ,new & ,non(ficial ,rem$ies3 #bg ,! ,j\rnal ,a4 ,m4 ,a41 ,sept4 #aa1 #aiji1 p4 #hfi4 8,! ,c\ncil has n det]m9$ :e!r digal5 conta9s #8soluble amorph\s digitox9' or n1 b accepts x simply z a soluble digitalis prep>ation40 ,tablets ( ,digal5 7 accept$ by ! ,c\ncil z a dosage =m ( ,digal54 ,ea* tablet is said to repres5t #j4e c4c4 7eight m9ims7 ( ,digal5 7liquid74 ,"o ( ! pr9cipal consid]ations :i* l$ ! ,c\ncil to accept ,digal5 0 t x 0 reg>d$ z af=d+ a fairly con/ant & /able prep>ation ( digitalis suitable = intrav5\s adm9i/ration4 ,if ,digal5 is n fairly /able & ( fairly con/ant composition x has no obvi\s advantage ov] an active soluble digitalis prep>ation1 su* z digitale94 ,! evid5ce n[ at h& seems to %[3 #a4 ,digal5 is n ( con/ant composition or activity4 #b4 ,! manufactur]s1 or _! ag5ts1 cont9ue to make mislead+ /atem5ts4 #c4 ,x is m]ely a solution ( c]ta9 digitalis pr9ciples1 probably ( digital5 ma9ly1 9 impure =m4 ,,composition ,cloetta#bh prep>$ a soluble amorph\s sub/ance :i* he call$ 8,digitox9um solubile ,cloetta10 b no in=mation conc]n+ ! me?od ( prep>ation has be5 publi%$4 #bh ,cloetta3 ,mn*54 m$4 ,w*ns*r41 #aijd1 ,no4 #cc4 ,cloetta report$ ! result ( an elem5t>y analysis ( 8 product :i* he comp>$ to ! analyses ( digitox9 7cry/all9e7 made by ,s*mi$eb]g & by ,kiliani1 & /at$ t !re c\ld be no d\bt conc]n+ ! *emical id5tity ( ! two sub/ances4 ,kiliani#bi *>act]iz$ z prepo/]\s ,cloetta's claim t ! active con/itu5t ( ,digal5 is *emically id5tical ) digitox9 & /at$ t ,digal5 0 m]ely an impure digitale94 ,kiliani has rec5tly reit]at$ ! /atem5t t ! s-call$ 8amorph\s digitox90 is n id5tical ) digitox94#cj #bi ,kiliani3 ,mn*54 m$4 ,w*ns*r41 #aijg1 p4 #hhf4 #cj ,kiliani3 ,am4 ,j\r4 ,ph>m41 #aiac1 lxxxv1 #bbd4 ,cloetta's failure to publi% 8 me?od ( prep>+ ,digal5 places an additional burd5 ( pro( on him 7or ! manufactur]s ( ,digal571 conc]n+ ! id5tity ( ! product1 & 9 ! face ( ,kiliani's d5ial ( ! correctness ( ,cloetta's cont5tion we mu/ h /rong corroborative evid5ce ( ,cloetta's claim be=e we c accept x z be+ e/abli%$4 ,! difficulties ( deal+ ) ! *emi/ry ( digitalis are s well kn[n t !y h>dly require fur!r m5tion "h1 b "u ! circum/ances ,cloetta _c be consid]$ z be+ :olly unprejudic$1 &1 :ile ! same might p]haps be said ( ,kiliani1 su* evid5ce z c be d$uc$ t5ds /rongly to support ,kiliani's view1 & to disprove ! cont5tion ( ,cloetta4 ,!re is mu* confusion reg>d+ ! names :i* h be5 appli$ to ! v>i\s pr9ciples obta9$ f digitalis1 & :ile x is undesirable t an e/abli%$ "n %\ld be giv5 to a newly discov]$ pr9ciple1 "o might ov]look ?is if no ef=t 7 made to associate ! !rapeutic actions ( ! two sub/ances to an ext5t :i* ! tru? did n ju/ify4 ,:ile ! ,c\ncil at t "t did n *all5ge ! exi/5ce ( 8amorph\s digitox90 & made no attempt to det]m9e ! id5tity ) digitox9 ( ! sub/ance =m+ ! basis ( ,digal51 ! manufactur]s ( ,digal5 h s\ght to %[ t ,digal5 & digitox9 7 id5tical s f> z _! !rapeutic actions 7 conc]n$1 b t ,digal5 lack$ ! disadvantages ( digitox94 ,:at 0 a purely academic "q :5 ! acceptance ( ,digal5 0 "u discussion by ! ,c\ncil becomes a matt] ( v great practical importance :5 ! manufactur]s ( ,digal5 seek to mislead ! physician by ^! claims4 ,! evid5ce :i* l5ds support to ! view t ,digal5 & digitox9 are :olly dissimil> may be summ>iz$ z foll[s3 ,digal5 diff]s greatly 9 its physical prop]ties f digitox9 & 9 c]ta9 ( its physiologic actions1 z ! manufactur]s !mselves /ate1 ,digal5 be+ amorph\s1 & soluble 9 wat]1 :ile digitox9 is cry/all9e & insoluble 9 wat]4 ,! manufactur]s /ate t ,digal5 diff]s f digitox9 9 c]ta9 ( its physiologic actions1 b ! two sub/ances d inde$ diff] f> m ?an !y admit4 ,cloetta & ! manufactur]s ( ,digal5 lay especial /ress on ! claim t ,digal5 is cumulative to a f> less ext5t ?an digitox91 & t x has f> less t5d5cy to cause ga/ric di/urbance ?an ! latt]4 ,! fir/ ( ^! claims is true2 ! second is ! v opposite ( ! tru?1 z we %all %[4 ,we "k no?+ ( ! /ructure ( any ( ! digitalis pr9ciples1 & ev5 ?\gh "o 7 to admit 7purely = ! sake ( argum5t7 t ,digal5 & digitox9 7 *emical isom]s1 t fact c\ld n be tak5 to l5d any support to ! cont5tion t ! two sub/ances 7 id5tical1 9 ! face ( ! e/abli%$ fact t !y diff] physically & physiologically 9 ne>ly e p>ticul>1 & agree only 9 t !y bo? cause /&/ill ( ! he>t 9 ! same way--an action possess$ also by s dissimil> a sub/ance z b>ium4 ,! manufactur]s ( ,digal5 support ! claim ( ! id5tity ( _! product ) digitox9 by /at+ t 8,digal5 is a solution ( ! mo/ active glucoside ( digitalis40#ca ,( c\rse1 x is v g5]ally admitt$ t digitox9 is ! mo/ active pr9ciple ( digitalis1 ?\gh !re is "s "q conc]n+ its glucosidal nature4 #ca ,cl9ical ,sugge/ions & ,reports1 ,decemb]1 #aiab1 p4 #bd4 ,digal5 is 9 fact f> less active ?an digitox91 z has be5 %[n by a numb] ( indep5d5t obs]v]s,m 7,wor? ,hale1 #aiaj2 ,hat*] & ,brody1 #aiaj2 ,neave1 #aijg2 ,mill]1 #aijh2 ! ref]ee2 ,weis1 #aiab74 ,m ,ow+ to lack ( space a portion ( ! report is "h omitt$4 ,a detail$ discussion ( ^! results is includ$ 9 ! full report conta9$ 9 ! repr9t4 ,! ess5tial fact :i* appe>s f ! inve/igation ( ,weis is t ,digal5 did n behave l digitox9 9 any case4 ,hale also f\nd t ,digal5 gave atypical actions 9 :i* ! effects on ! c5tral n]v\s sy/em became prom95t4 ,! ref]ee c corroborate ^! obs]vations ( ,hale's on frogs1 b ! convulsive symptoms 7 prom95t ) "s specim5s ( ,digal5 on mammals1 ?\gh n ) o!rs1 ! m rec5t specim5s ( ! prep>ation %[+ ! action prom95tly4 ,! results ( all ^! biologic te/s1 z well z ( ! physical te/s made by ,weis1 c]ta9ly l5d no support to ! cont5tion ( ,cloetta t ! pot5t con/itu5t ( ,digal5 is id5tical ) digitox91 b1 on ! contr>y1 !y %[ conclusively t ! two sub/ances diff] widely 9 _m ess5tials1 & ! cont9u$ claim ( ! manufactur]s t ! 8amorph\s digitox90 said to be conta9$ 9 ,digal5 is ! same z digitox91 or t x is ! mo/ active glucosid ( digitalis1 c be consid]$ only z mislead+1 & !re=e 9 conflict ) ! rules ( ! ,c\ncil4 ,,con/ancy ,,( ,,composition ,,& ,,acidity ,! manufactur]s ( ,digal5 cont9ue to claim t x is ( con/ant & uni=m activity1#cb & !y imply ?is ev5 :5 !y d n /ate x 9 ^? words2 = example1 a sub/ance _c be consid]$ reliable if x is v>iable 9 activity4 8,digal5 is ,absolutely ,reliable4 ,x is ,/&>diz$ & consequ5tly always uni=m4 ,x does n produce ga/ric di/urbances40 #cb ,adv]tisem5t ,brit4 ,m$4 ,j\r41 ,april #bf1 #aiac4 ,t ! =ego+ is absolutely untrue c be %[n abundantly4 ,hale#cc f\nd digal5 n to be uni=mly /able2 ,weis f\nd v diff]5t degrees ( activity = ,digal5 9 ! liquid & tablet =ms1 ! tablets be+ b "o-?ird z active z ! liquid1 & ! ref]ee f\nd v great v>iations 9 ! activity ( diff]5t specim5s ( ,digal51 "o specim5 be+ almo/ in]t4 ,! results obta9$ by ,mill] %[ t ,digal5 is sometimes v slightly active1 or n at all s4 #cc ,hale3 ,hyg4 ,lab4 ,bull41 #gd4 ,! =ego+ citations %[ conclusively t ,digal5 is n ( uni=m activity4 ,:5 reliability is claim$ = ,digal5 9 contra/ to ! kn[n v>iability ( digitalis1 x mu/ be consid]$ z tantam\nt to ! claim t ,digal5 is n subject to su* v>iability & x mu/ be held t ! manufactur]s make mislead+ /atem5ts :5 !y ass]t t ,digal5 is absolutely reliable4 ,! manufactur]s claim t ,digal5 does n produce ga/ric di/urbances 7see adv]tisem5t cit$74 ,x is q true t :5 small doses ( ,digal5 are us$ !rapeutically x fails to produce ga/ric di/urbances because x is ( su* slight activity1 z previ\sly /at$1 b :5 x is us$ 9 am\nts :i* correspond 9 activity to su* doses ( ! ord9>y gal5ical prep>ations ( digitalis z commonly cause nausea & vomit+ x does cause ga/ric di/urbances q z readily z ! latt]4 ,among ! cl9icians :o h f\nd t ,digal5 causes ga/ric di/urbances may be cit$3 ,veiel1#cd ,muell]1#ce ,ei*hor/#cf & ,tei*mann4#cg #cd ,veiel3 ,mn*54 m$4 ,w*ns*r41 #aijf1 liii1 #badj4 #ce ,muell]3 ,mn*54 m$4 ,w*ns*r41 #aiji1 lvi1 #ijd4 #cf ,ei*hor/3 ,deuts*4 m$4 ,w*ns*r41 #aije1 xxxi1 #di4 #cg ,tei*mann3 ,!rap4 d4 ,geg5w41 #aijg1 xlviii1 #aii4 ,eggle/on & ,hat*]#ch comp>$ ! emetic & c>diac activity ( ,digal5 & num]\s o!r digitalis bodies & prep>ations & f\nd t ! emetic activity ( ,digal5 0 decid$ly great] 9 proportion to its c>diac 7or !rapeutic7 action ?an 0 t ( digitalis or digitox94 #ch ,eggle/on1 ,c>y1 & ,hat*]1 ,rob]t1 ,a43 ,! ,emetic ,action ( ! ,digitalis ,bodies1 ,! ,j\rnal ,a4 ,m4 ,a41 ,feb4 #ae1 #aiac1 p4 #dii4 ,9 ! abs5ce ( any evid5ce to controv]t ?is cl9ical & exp]im5tal evid5ce1 ! cont9u$ claim t ,digal5 does n di/urb ! /oma* mu/ be look$ on z delib]ate misrepres5tation4 ,,mislead+ ,,!rapeutic ,,claims ,! recomm5dation t ,digal5 be dismiss$ f ,n4 ,n4 ,r4 is made ) ! full appreciation ( ! fact t ! manufactur]s ( ,digal5 & _! ag5ts h repeat$ly /at$ t !y desir$ to comply ) ! rules ( ! ,c\ncil1 & t !y h )drawn sev]al /atem5ts to :i* ! ,c\ncil has tak5 exception1 b ! fact rema9s t despite ^! reit]ations ! adv]tisem5ts ( ,digal5 cont9ue to embody /atem5ts :i* ! ,c\ncil c only consid] mislead+4 ,! ,c\ncil believes t ! foll[+ adv]tisem5ts con/itute gross !rapeutic exagg]ations3 8,digal5 a %eet an*or 9 pneumonia2 a /rong support to ! he>t 9 ?is deadlie/ ( infecti\s diseases among adults4 ,! prompt action ( ,digal51 by intrav5\s or intramuscul> injection makes x possible to save lives :i* might be o!rwise hopelessly lo/4 ,! be/ digitalis prep>ation :i* we h at ! pres5t "t40#ci #ci ,adv]tisem5t 9 ,am4 ,m$41 ,janu>y & ,febru>y1 #aiac4 8,! digitalis = *ildr54 ,because its dosage c be controll$4 ,endors$ by p$iatri/s ev]y:]e40#dj #dj ,adv]tisem5t 9 ,m]ck's ,ar*41 ,april1 #aiac4 8,! myoc>ditis ( ,tub]culosis s frequ5tly enc\nt]$1 especially 9 ! advanc$ /age ( ! disease1 may be controll$ ) ! aid ( ,digal54 ,! /&>d digitalis prep>ation40#da #da ,s\?4 ,m$ical ,j\rnal1 ,janu>y to ,may1 #aiac1 inclusive4 8,digal5 is ,absolutely ,reliable4 ,x is /&>diz$ & consequ5tly always uni=m4 ,x does n produce ga/ric di/urbances40#db #db ,adv]tisem5t 9 ,brit4 ,m$4 ,j\r41 ,april #bf1 #aiac4 ,digal5 is n a %eet an*or 9 pneumonia1 = !re is no drug des]v+ su* a title4 ,digal5 has no action :i* o!r digitalis prep>ations lack1 & _c save lives o!rwise hopelessly lo/4 ,! dosage ( ,digal5 _c be controll$ any bett] ?an t ( o!r digitalis prep>ations1 s9ce its activity is v>iable4 ,we _c control ! myoc>ditis ( advanc$ tub]culosis by ?is or any o!r means4 ,,claim$ ,,sup]iority ,v>i\s digitalis pr9ciples1 includ+ digitox91 digital9 7true7 & digitale91 h be5 kn[n = _m ye>s4 ,!rapeutically !y h be5 f\nd want+ & !re appe>s to be no basis = ! cont9u$ claim t ,digal5 has any sup]iority ov] ^! sev]al digitalis pr9ciples4 ,on ! contr>y1 ! evid5ce is accumulat+ t ,digal5 has no advantage 9 any p>ticul> ov] a solution ( digitale91 & mislead+ claims ( ! manufactur]s & _! ag5ts c]ta9ly int]f]e ) ! =mation ( t calm & unbias$ op9ion on ! "p ( ! g5]al practition]1 :i*1 :5 appli$ to ! non-propriet>y digitalis pr9ciples has caus$ !m to fall into disuse4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,sept4 #e1 #aiad47 ,,diorad9 ,,refus$ ,,recognition ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,a prep>ation call$ ,diorad9 0 plac$ on ! m>ket z a cure = consumption ?ree ye>s ago 9 ,europe & some:at lat] 9 ?is c\ntry4 ,x 0 fir/ submitt$ to ! ,c\ncil 9 ,july1 #aiaa4 ,because ( ! manife/ly unw>rant$ claims made = its use 9 ! treatm5t ( tub]culosis1 ! ,c\ncil vot$ t ! product be refus$ recognition = conflict ) ,rule #h1 )\t at t "t tak+ "u consid]ation ! "q :e!r or n x 0 9 conflict ) o!r rules ( ! ,c\ncil4 ,9 ,june1 #aiab1 fur!r consid]ation ( ,diorad9 0 reque/$4 ,! ,am]ican ag5t hav+ promis$ a re=m 9 ! me?ods ( adv]tis+1 ! ,c\ncil consid]$ ! available evid5ce reg>d+ ! id5tity & value ( ! prep>ation4 ,exam9ation ( evid5ce reg>d+ ! composition ( ,diorad9--claim$ to consi/ ( radium *lorid1 iod(orm & m5?ol 9 an e!r-oil solution--%[$ s]i\s discrepancies z to ! am\nt ( radium z well z to ! id5tity & am\nts ( o!r con/itu5ts4 ,x 0 fur!r f\nd t ! exp]im5tal evid5ce 0 insuffici5t & bias$4 ,!n1 too1 9 view ( ! difficulty ( judg+ ! effects ( m$ic9es 9 tub]culosis1 ! cl9ical data 7 unconv9c+4 ,!re 0 no?+ to prove t ! report$ improvem5ts1 ev5 if !y actually occurr$1 7 to be ascrib$ to ! mixture z a :ole r ?an to any "o ( its con/itu5ts4 ,z a result ( ^! f9d+s1 ! ,c\ncil vot$ t ,diorad9 be refus$ recognition & t ! publication ( ^! facts be au?oriz$4 ,9 accordance ) its regul> proc$ure1 x also submitt$ ! report to ! ag5t4 ,9 reply ! ag5t submitt$ evid5ce :i* %[$ t he 0 n responsible = ! mis/atem5ts ab\t ,diorad9 b (f]$ no facts t affect$ ! ,c\ncil's f9d+s4 ,! entire matt] hav+ be5 ref]r$ to a second ref]ee1 m9or modifications ( ! fir/ draft ( ! report 7 au?oriz$4 ,s9ce !n ! ,diorad9 ,company has submitt$ two reports ( exam9ations ( ,diorad9 made = ! company 9 ,g]many %[+ a high] radium cont5t ?an t previ\sly f\nd4 ,^! reports d n alt] ! facts br\ght out 9 ! report ( ! ,c\ncil t ! composition ( ,diorad9 has be5 v>iable1 :i* pa/ v>iability ar\ses a feel+ ( unc]ta9ty or lack ( confid5ce4 ,9 view ( ?is ! am5d$ report 0 ord]$ publi%$ & appe>s bel[4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,,fir/ ,,submission ,,( ,,diorad9 ,diorad91 a prep>ation = ! treatm5t ( consumption orig9at$ by ,dr4 ,r4 de ,sz5deffy1 ,budape/1 ,hung>y1 0 submitt$ to ! ,c\ncil by ,l\is ,g]o1 ,ltd41 ,new ,york1 ) ! foll[+ /atem5t ( composition3 8,a radio-active prep>ation ( ,m5?ol1 ,iod9 & ,radium ,b>ium ,*lorid #a_/aj ( a drop2 9 e!r solution40 ,a circul> :i* accompani$ ! submission /at$3 8,prep>ation ,no4 #c ( ,diorad9 conta9s n only t]p9s b also iod9 salts4444 ,9 view ( ! fact t emanations ( ! radium z well z ! comb9ations ( ! evasive iod9 t]p9s ent] into ! organism ?r\gh ! lung44440 ,lat] ^! indef9ite /atem5ts ( composition 7 supplem5t$ by ! foll[+3 8,9 #ajj c4c4 !re are3 #a gr4 ,iod(orm4 #e ,m5?ol4 #aj drops ,radium *lorid solution 7#a milligr4 9 #ajj c4c4 ( wat]74 #e gr4 e!r4 #ij ,oil 7ol4 amygd4 frig4 press740 ,9 a circul> conta9$ 9 ! package ^! claims 7 made3 8,! prep>ations ( ! ,diorad9 are bas$ on ! miracul\s effects :i* sci5tific rese>*es h %[n 9 reg>d to ! diff]5t sicknesses treat$ ) radium4 8,x is g5]ally kn[n t radium1 ev5 if ext]nally employ$1 has prov$ itself to be a bact]icidal rem$y4 ,its effect is multipli$ if "o employs x int]nally ev5 9 inf9itesimal doses1 9 consequ5ce ( its p]man5t action ( emanation on ! organism4 8,! prep>ations ( ! ,diorad9 conta9 ! radium itself4 ,= ?is reason _! antiseptic & bact]icidal effect is mu* m int5sive ?an ) m$icam5ts :i* conta9 only its emanation1 :i* disappe>s 9 a %ort "t40 ,9 view ( ! g5]al extravagance ( ! claims made = its !rapeutic action ! prep>ation 0 reject$ )\t consid]+ o!r possible conflicts ) ! rules ( ! ,c\ncil4 ,,second ,,submission ,,( ,,diorad9 ,hav+ be5 advis$ ( ! rejection by ! ,c\ncil ( ,diorad9 ! ,am]ican ag5cy1 :i* 9 ! meantime _h become ! ,diorad9 ,co41 reque/$ fur!r consid]ation4 ,! ,c\ncil !re=e took up ! subject aga94 ,aft] c]ta9 typographical errors _h be5 correct$ ! foll[+ 0 n[ giv5 z ! composition3 8#a gram ,iod(orm4 #e grams ,m5?ol4 #aj drops ,radium ,*lorid ,solution 7conta9+ #a milligram ( radium *lorid 9 #ajj cubic c5timet]s ( wat]74 #e grams ,e!r4 #hi grams express$ oil ( almond4 ,?is liquid is put up 9 ampules conta9+ "o cubic c5timet] ( liquid40 ,9 support ( ! !rapeutic claims = ,diorad9 ! ,am]ican ag5t submitt$ lit]ature consi/+ *iefly ( articles by ,dr4 ,b]nheim ( ,p>is4 ,be=e report+ on ! reque/$ reconsid]ation ( ,diorad9 ! ref]ee direct$ ! secret>y ( ! ,c\ncil to po9t out to ! ,am]ican ag5t t 9 ! =mula giv51 ! am\nt ( non-volatile matt] %\ld be ab\t #ij p] c5t41 :]eas ! report ( ! ,l$]le ,laboratories :i* accompani$ ! reque/ = reconsid]ation /ates t b #gb4jh p] c5t4 0 f\nd 9 ! analysis4 ,9 reply ! ag5t /at$ t he _h call$ ! att5tion ( ,dr4 ,sz5deffy 7! orig9ator ( ,diorad97 to ! discrepancies conc]n+ non-volatile matt] & t he felt sure ! discrepancy 0 :olly accid5tal 7sic74 ,9 a lat] communication ! ag5t submitt$ a /atem5t ( analysis f ! ,l$]le ,laboratories ( a new specim5 ( ,diorad9 accord+ to :i* ! am\nt ( non-volatile matt] agre$ ess5tially ) ! am\nt claim$ by ! ag5t4 ,! ref]ee1 hav+ exam9$ ! evid5ce1 is ( ! op9ion t ! /atem5t ( composition is mislead+ & t ! !rapeutic claims are unw>rant$1 ?us3 ,,discrepancies ,,9 ,,radium ,,cont5t ,! *ief claims = its !rapeutic value are bas$ on ! radium cont5t1 yet ! discrepancies & contradictions1 reg>d+ ?is are s]i\s4 ,9 connection ) ! reconsid]ation ( ?is product ! ag5t pres5t$ a c]tificate ( *emical exam9ation by ! ,l$]le ,laboratories 9 :i* ! foll[+ /atem5t 0 made z to ! radio-activity3 8,exam9ation %[s ! prep>ation to possess slight radioactivity1 correspond+ 9 activity to less ?an #a-aj1jjj ( #a milligram ( radium bromid p] ampule4 ,accord+ to ! sworn /atem5t ( ,dr4 ,a4 de ,sz5deffy1 ! orig9ator ( ,diorad91 ! prep>ation conta9s #aj drops ( radium *lorid solution 7#a milligram 9 #ajj cubic c5timet]s ( wat]7 9 #ajj cubic c5timet]s ( ! prep>ation4 ,?is w\ld correspond to #e-a1jjj milligram ( radium *lorid 9 #ajj cubic c5timet]s1 or ab\t #a-bj1jjj ( #a milligram p] ampule40 ,a cursory read+ ( ?is p>agraph gives ! impression t ,diorad9 possesses fully ! am\nt ( radio-activity claim$ by its orig9ator1 ,dr4 ,a4 de ,sz5deffy4 ,?is impression is greatly /r5g!n$ by ! conclud+ p>agraph ( ! ,l$]le report1 :i* says3 8,9 conclusion1 our exam9ation %[s t ! prep>ation submitt$ to u z ,diorad9 possesses radio-activity1 & conta9s a fix$ oil 7app>5tly express$ oil ( almond71 iod(orm1 m5?ol & e!r1 ?us confirm+ ! sworn /atem5t ( ,dr4 ,a4 de ,sz5deffy 9 reg>d to ! composition ( ?is product40 ,on inquiry z to ! me?od us$ by ! ,l$]le ,laboratories1 9 det]m9+ radio-activity ! ag5t submitt$ a fur!r /atem5t ( ! ,l$]le ,laboratories :i* describes ! gamma ray te/ by :i* ! det]m9ation 0 made & a radium value equival5t to #j4jjjjda mg4 ( radium bromid p] capsule 0 obta9$4 ,! report !n says3 8,! v>iations ( ! s+le measurem5ts f ! mean 9 ! case ( ! natural leak & ! leak ) ! ,diorad9 ne> 7 s l>ge t we did n feel ju/ifi$ 9 assign+ mu* accuracy to ! figure1 #j4jjjjda1 b /at$ t ! am\nt ( radium p] capsule c\ld n be great] ?an #j4jjja mg41 ) ! possibility ( !re be+ a mu* small] am\nt pres5t40 ,x is evid5t t ! word+ ( ! reports ( ! ,l$]le ,laboratories is liable to give ! impression t _! exam9ation confirms ! claims made = ,diorad94 ,x is fur!r evid5t f ^! reports t ! am\nt ( radio-active matt] has n be5 def9itely asc]ta9$ b t x is at ! be/ v small4 ,! unreliability ( ! claims = radium cont5t ( ,diorad9 0 rec5tly %[n by ,bue*n]1#dc :o f\nd a specim5 obta9$ f an apo!c>y to conta9 b #a-a1jjj ( ! am\nt claim$4 #dc ,bue*n]3 ,ph>m4 ,weekblad1 ,m>* #b1 #aiab1 p4 #afa4 ,,volatile ,,& ,,non-,,volatile ,,matt] ,! v>y+ claims reg>d+ ! cont5t ( volatile & non-volatile matt] ?r[ d\bt on ! entire composition ( ,diorad91 = if ! /atem5t z to ^! is wrong ! re/ ( ! /atem5t reg>d+ composition _c be giv5 cr$5ce4 ,9 ! fir/ submission ( ,diorad9 ab\t #hi p] c5t4 ( non-volatile matt] 0 claim$ b 9 ! report ( ! analysis by ! ,l$]le ,laboratories1 :i* accompani$ ! resubmission1 only ab\t #gb p] c5t4 0 f\nd4 ,lat] ! ,l$]le ,laboratories report$ t an exam9ation ( a new specim5 ( ,diorad9 _h %[n ab\t #ij p] c5t4 ( non-volatile matt]4 ,! discrepancies betwe5 ! composition claim$ = ,diorad9 & t f\nd = ! product 9 ! fir/ ,l$]le report has %[n t ! ag5t 0 q ignorant ( ! composition ( ! product :i* he 0 sell+4 ,,indef9it5ess ,,( ,,! ,,iod9 ,,cont5t ,! label on ! trade package ( ,diorad9 fir/ submitt$ to ! ,c\ncil /at$ t ! product conta9$ iod(orm2 a simil> /atem5t 0 made 9 ! submission ( ! product2 ! circul> accompany+ ! fir/ submission /at$ t 8iod9 salts0 7 conta9$ 9 ! product :ile ! iod9 cont5t 0 ref]r$ to fur!r on 9 ?is circul> z 8comb9ations ( evasive iod9 t]p9s40 ,9 ,b]nheim's pap]s1 :i* h be5 us$ to adv]tise ,diorad91 & :i* are ref]r$ to 9 ! same circul>1 ! iod9 comp\nd is call$ 8iode peptonis10 :i*1 accord+ to in=mation /at$ by ! ,am]ican ag5t to h come f ,budape/1 is to be translat$ 8iodiz$ peptone40 ,:at is ! mean+ ( ?is confusion8 ,"o w\ld naturally suppose t ! prep>ation to be sold 9 ?is c\ntry conta9s iod(orm 9 an e!r-oil solution :ile ! "o us$ by ,b]nheim & ,dieup>t#dd 0 /at$ to conta9 an e!real solution ( 8iodiz$ peptone40 ,?is is ano!r my/ification1 = an e!real solution ( any k9d ( peptone w\ld be a novelty4 ,! matt] is ( "s importance1 = ,b]nheim & ,dieup>t lay great /ress on ! diff]5ce betwe5 8peptoniz$ iod90 & o!r iod9 7loc4 cit41 p4 #ccc7 & ( ! sup]iority ( e!real ov] oily solutions 7loc4 cit41 p4 #ccd74 ,! ,am]ican ag5ts1 h[ev]1 9 ! second submission1 /ate t ?is is all a mi/ake2 t ! ,diorad9 us$ by ,b]nheim is ! same ,diorad9 :i* 0 submitt$ to ! ,c\ncil2 & t ?is does n conta91 & nev] did conta91 ! e!real solution ( 8iode peptonis0 to :i* ,b]nheim atta*$ s great importance4 ,b]nheim 7report to ,m$ical ,congress ( ,lyons7 himself has come to ! same conclusion2 = five mon?s aft] 8 fir/ pap] he believes t ! 8special salt ( radium0 7sic7 is ! pr9cipal ag5t2 s t ! 8peptoniz$ iod90 mu/ be unimportant1 & 9 a cablegram ( ,july #d1 #aiab1 he n[ in=ms ! ,diorad9 ,company t ! =mula 0 incorrectly giv5 9 8 fir/ pap]s 8ow+ to my ignorance ( actual composition10 & t all ! ,diorad9 us$ by him 0 ( ! composition /at$ 9 ! submission to ! ,c\ncil4 #dd ,b]nheim & ,dieup>t3 ,revue ,int]nationale de la ,tub]culose1 ,may1 #aiaa1 p4 #ccf4 ,:ile ?is v9dicates ! good fai? ( ! ,am]ican ,diorad9 ,company1 x does n cle> up ! my/]y4 ,! "q occurs at once3 ,:at l$ ,dr4 ,b]nheim to make su* positive /atem5ts8 ,0 he draw+ purely on 8 imag9ation8 ,if s1 :y did 8 imag9ation take ?is peculi> special direction8 ,or if he did h "s reason to imag9e ! 8iode peptonis10 :o suppli$ ?is reason8 ,& if1 at t "t1 he 0 giv5 to und]/& by ,sz5deffy1 :o mu/ h suppli$ him ) ! mat]ial1 t x conta9$ ! iodiz$ peptone1 h[ c he be positive at ?is "t1 t x did n conta9 x8 ,has he actually analyz$ ! old mat]ial8 ,!re is also a fur!r "q :i* ne$s to be answ]$4 ,:y has ,dr4 ,sz5deffy wait$ until ,diorad9 0 reject$ by ! ,c\ncil be=e correct+ ,b]nheim's s]i\s misappreh5sion1 9 ! meantime p]mitt+ ! circulation ( ,b]nheim's pap]8 ,until ^! que/ions h be5 satisfactorily answ]$1 ! elem5t ( my/]y ab\t ! composition ( ,diorad9 _c be cle>$ away4 ,,exp]im5tal ,,evid5ce ,! available exp]im5tal evid5ce reg>d+ 8,diorad90 is re/rict$ to "s quotations f its inv5tor ,sz5deffy1 9 ! pap] ( ,b]nheim & ,dieup>t 7p4 #ccd74 ,^!1 if confirm$1 w\ld %[ t radium alone has practically no effect on cultures ( tub]cle or colon bacilli2 t #j4a gm4 ( 8iode-m5?ol0 7conc5tration n /at$7 *ecks ! gr[? ( ! acid-fa/ organisms2 & t ?is antiseptic effici5cy c be ne>ly d\bl$ by ! addition ( a little radium4 ,no quantitative data are giv51 s t x is difficult to judge ! accuracy ( ! obs]vation4 ,grant+ t x is correct1 x w\ld h little be>+ on ! !rapeutic actions ( ,diorad91 = !re is no?+ to %[ t ! effective te/-tube conc5tration is rea*$ 9 ! pulmon>y tissues4 ,x is also claim$ t ! injection ( ,diorad9 prev5ts tub]cle infection4 ,! ref]ee believes t ! ,c\ncil & ! m$ical pr(ession %\ld hesitate to accept ?is conclusion )\t fur!r details2 & ^! w\ld require confirmation by unprejudic$ obs]v]s4 ,,cl9ical ,,evid5ce ,! ,diorad9 ,company submits consid]able cl9ical data 9 favor ( ,diorad94 ,x mu/ be rememb]$ t mo/ favorable op9ions h be5 publi%$1 f "t to "t1 ab\t scores ( 8consumption cures10 :i* h my/]i\sly lo/ _! effici5cy :5 _! novelty wore away4 ,!re is no m reason to d\bt ! good fai? ( ^? :o are en?usia/ic ab\t ,diorad9 ?an ( ^? :o h be5 en?usia/ic ab\t o!r 8cures40 ,!re appe> to be features 9 ! c\rse ( tub]culosis :i* make ! judgm5t ( !rapeutic measures peculi>ly difficult4 ,x is possible t imp>tial cl9ical trials ( ,diorad9 by tub]culosis exp]ts appo9t$ by ! ,c\ncil might facilitate judgm5t z to ! actual effici5cy ( ,diorad94 ,! ref]ee d\bts1 h[ev]1 :e!r ?is w\ld advance ! ,c\ncil v mu* t[>d ! acceptance ( ! sub/ance4 ,su* an inve/igation w\ld be s l5g?y t x %\ld n be und]tak5 until ! ,diorad9 ,company itself has (f]$ at lea/ presumptive evid5ce 9 ?is direction1 especially 9 view ( ! adv]se report rec5tly made by ,cecil ,wall4#de ,t5 tub]cul\s pati5ts 7 treat$ by ,wall 9 /rict accordance ) ! me?od outl9$ to him by ,b]nheim1 yet ,wall concludes t none ( ! cases1 ?\gh treat$ accurately 9 accordance ) ! in/ructions1 c be quot$ to ju/ify any ( ! claims = ! !rapeutic effici5cy ( ,diorad94 ,! ,c\ncil _c und]take l5g?y inve/igations ( ?is "* until x is put 9 possession ( data :i* w\ld %[ to its satisfaction t su* inve/igations w\ld probably be fruitful4 #de ,wall1 ,c43 ,brit4 ,m$4 ,j\r41 ,july #bj1 #aiab1 p4 #aji4 ,,conclusions ,f inve/igations made1 x appe>s t ! claims 9 reg>d to ! composition ( ,diorad9 h conta9$ vague /atem5ts & contradictions :i* ar\se a feel+ ( unc]ta9ty & lack ( confid5ce4 ,until ?is unc]ta9ty is cle>$ away1 ,diorad9 _c be consid]$ z comply+ ) ,rule #a4 ,! exp]im5tal data are insuffici5t & unconv9c+4 ,"s favorable cl9ical reports h be5 submitt$1 b ! accuracy ( ! obs]vations is to be que/ion$ & !y are m ?an (fset by ! negative results obs]v$ by ,cecil ,wall4 ,z might be expect$1 o!r negative results1 if obs]v$1 h n be5 submitt$ & !re is no?+ 9 ! manufactur]'s claim to %[ :e!r ! improvem5t report$ is really due to ! peculi> mixture call$ ,diorad9 or to any "o ( its +r$i5ts4 ,x is !re=e recomm5d$ t ,diorad9 be n accept$ = ,new & ,non(ficial ,rem$ies4 ,9 view ( ! ext5sive adv]tis+ ( ?is prep>ation & because ( ! admitt$ly incorrect /atem5ts 9 ! e>li] pap]s x is recomm5d$ t publication ( ?is report be au?oriz$4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,oct4 #bf1 #aiab47 ,,e*9acea ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has vot$ to reject sev]al non-propriet>y articles & has recomm5d$ t ! reasons = _! rejection be giv5 9 ,! ,j\rnal2 among ^! is e*9acea4 ,! foll[+ pap] has be5 submitt$ by a subcommittee ) ! recomm5dation t x be publi%$4 ,?is recomm5dation 0 adopt$4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,e*9acea ,:5 ?is drug 0 fir/ introduc$1 x 0 a typical no/rum1 ) exagg]ations reg>d+ its !rapeutic value t 7 some:at m gross ?an usual4 ,x 0 lat] adopt$ by ! eclectic s*ool )\t be+ fre$ f ! /igmata ( its orig94 ,x 0 also press$ into use z ! ma9 +r$i5t ( su* propriet>y prep>ations z ,e*afolta1 ,ec?ol ,eusoma1 etc4 ,ef=ts h be5 made to get ! regul> pr(ession to use x 9 ^! v>i\s =ms4 ,accord+ to ,j4 ,u4 ,lloyd 7,ph>m4 ,review1 vol4 xxii1 p4 #i-ad71 ! introduction ( e*9acea into eclectic m$ic9e is due to ! ef=ts ( ,dr4 ,h4 ,f4 ,c4 ,mey] to increase ! sale ( ,mey]'s ,blood ,purifi]1 a secret rem$y conta9+ x4 ,! foll[+ is a lit]al copy ( ! label on ?is no/rum3 ---------------------------------------- -------------------- ,,mey]',s ,,blood ,,purifi] ,,directions ,?is is a p[]ful drug z an ,alt]ative & ,antiseptic cases3 ,rheumatism1 ,sick ,heada*e1 ,erysipelas1 ,dyspepsia1 ,old ,sores & ,biles1 ,op5 ,w\nds1 ,dizz9ess1 ,scr(ula & ,sore ,eyes4 ,9 case ( ,poison+ by ,h]bs1 ,c41 take ! d\ble dosis1 & ,bites ( ,rattlesnakes take ?ree ounces ?ree times a day1 until ! swell+ is gone4 ,?is is an absolute cure )9 #bd h\rs4 ---------------------------------------- -------------------- ,aft] ,lloyd _h id5tifi$ ! plant1 ,mey] put ! prep>ation out "u ano!r =m ) ! foll[+ label3 ---------------------------------------- ---------------------- ,,e*9acea ,,angu/efolia ,?is is a p[]ful drug z an ,alt]ative & ,antiseptic 9 all tumor\s & ,syphilitic indications2 old *ronic w\nds1 su* z fev] sores1 old ulc]s1 ,c>buncles1 ,piles1 eczema1 wet or dry1 c be cur$ quick & active2 also ,erysipelas4 ,x w n fail 9 ,gangr5e4 ,9 fev] x is a specific2 typhoid c be adv]t$ 9 two to ?ree days2 also 9 ,mal>ia1 ,malignant1 ,remitt5t & ,m\nta9 fev] x is a specific4 ,x relieves pa91 swell+ & inflammation1 by local use1 int]nal & ext]nal4 ,x has n & w n fail to cure ,diph!ria quick4 ,x cures bites f ! bee to ! rattlesnake1 x is a specific4 ,has be5 te/$ 9 m ?an fifty cases ( mad dog bites 9 human & 9 e case x prev5t$ hydrophobia4 ,x has cur$ hydrophobia4 ,x is p]fectly h>mless1 int]nal & ext]nal4 ,dose4--,"o half to "o fluid-dra*m #c or #d times a day4 ,manufactur$ by ,h4 ,c4 ,f4 ,mey]1 ,m4,d4 ,price1 ,pawnee ,city1 ,neb41 ,u4 ,s4 ,a4 ,pat5t ---------------------------------------- ---------------------- ,^! absurd claims ( an evid5tly ignorant man h pass$ into ! m rec5t propriet>y adv]tis+ matt]s & into mu* ( ! eclectic writ+s4 ,inde$1 ! seem+ly impossible _h be5 atta9$ by ev5 surpass+ ,mey]'s all-b-all-embrac+ claims4 ,n cont5t ) endors+ e*9acea z a positive & spe$y 8specific0 = rattlesnake bite1 syphilis1 typhoid fev]1 mal>ia1 diph!ria & hydrophobia1 lat] en?usia/s h cr$it$ x ) equally c]ta9 curative effects 9 tub]culosis1 tetanus & exoph?almic goit]1 & ) ! p[] ( ret>d+ ! developm5t ( canc]4 ,x is wor? notic+--al?\gh x is n surpris+--t ^! f>-rea*+ claims h be5 made on no bett] basis ?an t ( cl9ical trials by unkn[n m5 :o h n o!rwise a*iev$ any g5]al reputation z acute1 discrim9at+ & reliable obs]v]s4 ,no attempt seems to h be5 made to v]ify ^! claims by accurate sci5tific me?ods1 cl9ical or o!rwise1 al?\gh ?is c\ld v easily h be5 done4 ,n "o ( ! eulogi/ic report]s & exploit]s seems to h consid]$ x wor? :ile to det]m9e by ! simple/ control exp]im5ts :e!r ! drug possesses any bact]icidal or antiseptic p[]s :atev]4 ,x is !re=e n v /range t discrim9at+ physicians h fail$ to %[ mu* en?usiasm4 ,"o ( ! w>me/ endors]s ( e*9acea1 ,c4 ,s4 ,*amb]la9 7:o lat] became ! presid5t ( ! ,eusoma ,ph>maceutical ,company71 compla9s t he has be5 unable to int]e/ regul> physicians 9 ! rem$y4 ,he reviews ! /atem5ts ( previ\s au?ors & reports eight cases ( infection1 only two be+ acute or ext5sive1 9 :i* he us$ x ) ass]t$ success4 ,9 view ( ! lack ( any sci5tific scrut9y ( ! claims made = x1 e*9acea is deem$ unwor?y ( fur!r consid]ation until m reliable evid5ce is pres5t$ 9 its favor4 ,,ref]5ces ,mey]1 ,h4 ,f4 ,c43 ,eclectic ,m$4 ,j\r41 #ahhg2 ,goss3 ,*icago ,m$4 ,times1 #ahhh2 ,hages3 ,eclectic ,m$4 ,j\r41 #ahhh2 ,%elly3 ,m$ical ,glean]1 #ahid2 ,lloyd1 ,c4 ,g43 ,eclectic ,m$4 ,j\r41 #ahig2 ,lloyd1 ,j4 ,u43 ,eclectic ,m$4 ,j\r41 #ahig2 ,lloyd1 ,j4 ,u43 ,ph>m4 ,review1 xxii1 #i-ad2 ,s*nitz1 ,elsie ,m43 ,wis4 ,m$4 ,record]1 #ahih1 ii1 #bjb2 ,:ite1 ,j4 ,n43 ,texas ,m$4 ,news1 #ahih1 viii1 #aaj-aac2 ,/9son1 ,j4 ,c43 ,!rap4 ,gazette1 #aijj2 ,hale1 ,e43 ,lancet-,cl9ic1 ,m>*1 #aija2 ,?iel51 ,b4 ,f43 ,e*afolta1 ,its ,uses 9 ,d5tal ,surg]y1 ,d5tal ,reg41 #aijc1 vii1 #dfb-dfe2 ,gorse1 ,c4 ,a43 ,new ,albany ,m$4 ,h]ald1 #aijc-d1 xxii1 #chd2 ,*amb]la91 ,c4 ,s43 ,l\isville ,mon?ly ,j\r4 ,m$4 ,surg41 #aijd-e1 xi1 #bai-bbc2 ,lancet-,cl9ic1 #aije1 ,m4 ,s41 liv1 #bgi-bhc2 ,ell+wood1 ,f43 ,!rap4 ,gazette1 #aije1 #c1 ,s41 xxi1 #bih-cjj2 ,fr5*1 ,j4 ,m43 ,m$4 ,brief1 #aije1 xxxiii1 #ecg2 ,ma!ws1 ,a4 ,b43 ,georgia ,pract41 #aije1 i1 #acg-adj4--7;,f ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #bg1 #aiji47 ,,e*tisia1 ,,ec?ol ,,& ,,e*itone ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,e*tisia 7,wm4 ,s4 ,m]rell ,*emical ,co471 ,ec?ol 7,battle & ,co47 & ,e*itone 7,/rong1 ,cobb & ,co47 are propriet>y prep>ations ea* ( :i* is alleg$ to conta9 e*9acea z its *ief con/itu5t4 ,9 #aiji ! ,c\ncil exam9$ into ! claims made = e*9acea4 ,?is drug has be5 claim$ to be a 8specific0 = rattlesnake bite1 syphilis1 typhoid fev]1 mal>ia1 diph!ria & hydrophobia4 ,en?usia/s h cr$it$ x ) equally c]ta9 curative effects 9 tub]culosis1 tetanus1 & exoph?almic goit] & ) p[] ( ret>d+ ! developm5t ( canc]4 ,( c\rse !re is no reliable or tru/wor?y evid5ce to sub/antiate ^! claims4 ,e*9acea is n (t5 prescrib$ "u its own "n1 b is employ$ z an +r$i5t 9 propriet>y prep>ations mix$ ) o!r little-us$ or obsolete sub/ances4 ,?us ,e*tisia is said to conta9 e*9acea1 wild indigo1 arbor vitae & poke root2 ,ec?ol1 to h e*9acea & arbor vitae2 ,e*itone1 to consi/ ( e*9acea1 pansy & blue flag4 ,naturally ! manufactur]s ( su* propriet>ies make use ( all available optimi/ic reports 9 promot+ _! sale1 :ile ea* manufactur] ascribes special & peculi> virtues to ! comb9ation repres5t$ 9 8 p>ticul> prep>ation4 ,! ,m]rell ,*emical ,company claims t baptisia 7wild indigo7 is a 8de/roy]0 ( devitaliz+ elem5ts 9 ! blood 8a vitaliz] ( ! blood z well02 t ?uja 7arbor vitae7 is a 8p]fect antiseptic & a g5]ator ( vital =ce 9 disorganiz$ tissues10 & t a long li/ ( diseases1 includ+ diph!ria1 syphilitic sciatica & gonorrheal rheumatism1 8are all m or less am5able to full doses0 ( phytolacca 7poke root74 ,/rong1 ,cobb & ,co4 ma9ta9 t ,iris v]sicolor 7blue flag7 is 8"o ( ! mo/ p[]ful excitants ( ! bili>y1 saliv>y & pancreatic secretions10 & t ! 8pr9cipal sph]e ( action ( ,viola tricolor pansy is 9 ! ga/ro-inte/9al canal & ! sk940 ,!re is no satisfactory evid5ce t ! claims = any ( ^! sub/ances are any m reliable ?an ^? = e*9acea4 ,not)/&+1 ,/rong1 ,cobb & ,co4 claim = ,e*itone 8n only ! virtues ( its con/itu5t p>ts1 b a wid] field & a p>ticul> !rapeutic value ( its own02 ,battle & ,co41 ma9ta9 t ,ec?ol is ! 8#8,ideal ,corrector' ( deprav$ conditions ( ! fluids & tissues10 :ile ! ,m]rell ,company urges ! virtues ( ,e*tisia 9 a li/ ( diseases rang+ f acne to app5dicitis & f gangr5e to rattlesnake bite4 ,! ,c\ncil refus$ recognition to ^! ?ree products & direct$ publication ( reports to call att5tion to ! exagg]at$1 unw>rant$ & (t5 utt]ly absurd claims made = ^! & simil> prep>ations4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #b1 #aiae47 ,,ergoapiol,n ,ab/ract ( ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,n ,= ab/ract ( report on a simil> mixture1 see ,ap]gols1 p4 #bf2 = unabridg$ report ( ! ,c\ncil's action on ,ap]gols & ,ergoapiol see ,reports ,c\ncil ,ph>m4 & ,*em41 #aiad1 p4 #fd4 ,ergoapiol 7,m>t9 ,h4 ,smi? ,co41 ,new ,york7 is a mixture put up 9 capsules1 ea* ( :i* is said to conta9 ,apiol 7,special ,m4 ,h4 ,s47 #e gra9s ,ergot9 #a gra9 ,oil ,sav9 #a_/b gra9 ,alo9 #a_/h gra9 ,exam9ation discloses ! fact t1 contr>y to ! claim made1 ea* capsule1 in/ead ( conta9+ #e gra9s ( apiol1 really conta9s "s liquid prep>ation ( ! type ( oleores9 ( p>sley se$4 ,ergoapiol is recomm5d$ 7on ! label7 = su* diseases z 8,am5orrhea1 ,dysm5orrhea & o!r ,m5/rual ,disord]s10 :ile a circul> enclos$ 9 ! package conta9s _m sugge/ions t may be c\nt$ on to lead to its indiscrim9ate & uncritical use4 ,ergoapiol is an unsci5tific1 %ot-gun mixture ( drugs hav+ widely diff]5t !rapeutic effects4 ,:]e ! action ( p>sley is desir$1 ! effects ( ergot w\ld ord9>ily1 be contra-indicat$2 fur!rmore1 nei!r alo9 or sav9 w\ld be call$ = 9 conditions t dem&$ ! effects ( apiol4 ,x w\ld be impossible to pr$ict ! action ( a mixture ( ?is k9d 9 ! v>y+ conditions = :i* its use is advis$ by ! manufactur]s4 ,to comb9e f\r drugs ( dissimil> action 9 fix$ proportions = ! r\t9e treatm5t ( conditions :i* h little 9 common except t !y involve ! female g5]ative organs1 is unsci5tific & absurd4 ,! ,c\ncil refus$ admission to ,ergoapiol4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,dec4 #ab1 #aiad47 ,,erpiol 7,,dr4 ,,s*rad]7 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! orig9al rules ( ! ,c\ncil gov]n+ ! acceptance ( articles h rec5tly be5 modifi$1 p>ticul>ly by adoption ( ,rule #aj1 :i* reads3 8,unsci5tific & ,useless ,articles4--,no article w be admitt$ :i*1 because ( its unsci5tific composition1 is useless or inimical to ! be/ int]e/s ( ! public or ( ! m$ical pr(ession40 ,9 view ( ^! modifications1 ! ,c\ncil is reconsid]+ ! articles already accept$ ) ! view ( det]m9+ _! compliance ) ! rules z am5d$4 ,9 l9e ) ?is ! ,c\ncil reconsid]$ ,erpiol 7,dr4 ,s*rad]71 manufactur$ by ! ,william ,s4 ,m]rell ,*emical ,company1 & f ! evid5ce giv5 bel[ conclud$ t "o ( ! con/itu5ts1 gossyp91 is in]t & its use unsci5tific4 ,! ,c\ncil !re=e vot$ t ,erpiol 7,dr4 ,s*rad]7 be omitt$ f ,new & ,non(ficial ,rem$ies & au?oriz$ publication ( ! foll[+ report4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,erpiol ,9 consequ5ce ( ! m ?or\gh scrut9y n[ giv5 by ! ,c\ncil to ! !rapeutic value ( ! rem$ies admitt$ to ,new & ,non(ficial ,rem$ies1 ! ,c\ncil has reconsid]$ ,erpiol 7,dr4 ,s*rad]71 previ\sly accept$ = ,new & ,non(ficial ,rem$ies4 ,erpiol 7,dr4 ,s*rad]7 is ! "n appli$ to capsules conta9+ apiol1 ergot9 & gossyp91 :i* are sold z an emm5agogue4 ,! fir/ two +r$i5ts h a recogniz$ value 9 ! treatm5t ( diseases ( ! female g5]ative organs4 ,! ?ird1 gossyp91 is a prep>ation f cotton-root b>k1 belong+ to ! some:at indef9ite class ( ph>maceutical prep>ations kn[n z res9oids4 ,cotton-root b>k 7,gossypii radicis cortex1 ,u4 ,s4 ,p47 has be5 cr$it$ by "s ) ph>macologic & !rapeutic prop]ties1 simil> to ergot1 especially 9 its action on ! ut]us2 exp]im5ts on pregnant animals d n confirm ?is view4 ,mo/ au?orities on gynecology ei!r make no ref]5ce :atev] to ! drug or ascribe little or no value to x4 ,! prep>ations f ! dri$ b>k are in]t4 ,f reports made to him1 ,pr(essor ,j4 ,u4 ,lloyd conclud$ 7,eclectic ,m$4 ,j\r41 #ahgf1 xxxvi1 #ede7 t a prime fluidextract ( fre% cotton-root b>k is an active !rapeutic ag5t & des]v+ ! att5tion ( ! m$ical pr(ession1 :ile t ( ! dry b>k is in]t & wor?less4 ,! gossyp9 on ! m>ket is made f ! dri$ b>k4 ,pr(essor ,lloyd1 :o is consid]$ an au?ority on eclectic m$ic9e1 says3 8,7 x left to me to admit or exclude x1 by reason ( its !rapeutical position1 ,i %\ld exclude x1 because1 9 my op9ion1 x has nev] be5 demon/rat$1 9 cl9ical practice1 to be wor?y ( any !rapeutic recognition :atev]40 ,z ! available evid5ce indicates t gossyp9 is an in]t prep>ation1 ,erpiol 7,dr4 ,s*rad]7 0 consid]$ 9 conflict ) ,rule #aj & ! ,c\ncil has !re=e vot$ t x be delet$ f ,new & ,non(ficial ,rem$ies4--7,f ! ,j\rnal ,a4 ,m4 ,a41 ,june #c1 #aiaa47 ,,false ,,unicorn 7,,helonias7 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil vot$ to refuse to recognize false unicorn z a non-propriet>y article & ! foll[+ /atem5ts1 submitt$ by a subcommittee1 7 ord]$ publi%$4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,false ,unicorn-,helonias ,helonias dioica1 or m prop]ly ,*amlirium luteum1 is a plant1 prep>ations ( :i* ent] into v>i\s propriet>y mixtures = diseases ( ! female pelvic organs4 ,9 ! adv]tisem5ts ( ^! prep>ations x is usually cr$it$ ) hemo/atic p[]s & is ass]t$ to be a ut]9e tonic4 ,!re is practically no ref]5ce to ?is drug 9 reliable m$ical lit]ature1 & z !re is no evid5ce wor?y ( cr$5ce to support ! claims made = x1 ! drug 0 n consid]$ des]v+ ( a place 9 ! ,ph>macopeia4 ,h5ce1 x may be reg>d$ z a drug n wor?y ( att5tion ( physicians4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #bg1 #aiji47 ,,=murol ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,=murol1 ,citrocoll & ,aspiroph5 7 submitt$ to ! ,c\ncil by ! ,cell>ius ,company ( ,san ,francisco4 ,! manufactur]s hav+ fail$ to sub/antiate ! claims !y make = ^! products1 ! ,c\ncil has vot$ t ! prep>ations be refus$ recognition4 ,! ,c\ncil also au?oriz$ ! publication ( ! foll[+ report1 :i* deals p>ticul>ly ) "o ( ! prep>ations--,=murol4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,=murol is ! product ( ! ,*emis*e ,fabrik ,falk5b]g1 ,falk5b]g-,gru5au1 ne> ,b]l91 ,g]many4 ,! ,cell>ius ,company1 ,san ,francisco1 act+ z sell+ ag5ts = ! ,unit$ ,/ates1 submitt$ ,=murol 7along ) ,aspiroph5 & ,citrocoll1 also made by ! same firm7 to ! ,c\ncil1 ) ! /atem5t t x is 8hexame?yl5tetram9sodium-citrate10 & t x has ! foll[+ composition3 8,c#f;,h#g,o#g,na4,c#f;,h#ab,n#d40 ,z]nik1#df :o exam9$ ^! products1 report$ t ,aspiroph51 ,citrocoll & ,=murol d n h ! composition t is claim$ = !m by ! ,fabrik ,falk5b]g4 ,=murol1 he /ates1 is n a def9ite *emical comp\nd1 b a mixture ( hexame?yl5am9 & sodium citrate4 ,! ag5ts 7 advis$ ( ?is fact by ! ,c\ncil & 7 ask$ to submit evid5ce to sub/antiate _! claims4 ,no su* evid5ce 0 submitt$4 #df ,z]nik3 ,arb4 a4 d4 ,ph>mazeut4 ,in/4 d4 ,univ4 ,b]l91 #aijg1 iv1 #df4 ,s9ce a comp\nd hav+ ! composition t is claim$ = ,=murol is !oretically possible1 ! ,c\ncil reque/$ t ! product be exam9$ 9 ! ,association ,laboratory to det]m9e :e!r x /ill 0 ! simple mixture report$ by ,z]nik1 or :e!r1 p]haps1 x n[ possess$ ! =mula claim$ = x4 ,! foll[+ report 0 made by ! ,association *emi/s3 ,=murol1 z submitt$ to ! ,c\ncil1 0 9 ! =m ( tablets weigh+ ab\t #a gm4 ea* & appe>$ to be compos$ ( a f9e :ite sub/ance int]sp]s$ ) "s transp>5t p>ticles4 ,! tablets 7 readily soluble 9 wat]1 7 odorless & possess$ a slightly acid ta/e4 ,! aque\s solution respond$ to te/s = hexame?yl5am91 citrate & sodium4 ,to det]m9e :e!r hexame?yl5am9 0 pres5t 9 ! free or ! comb9$ /ate1 ! me?od ( ,z]nik 0 employ$4 ,?is consi/s 9 ! extraction ( ,=murol ) *lor(orm1 :i* dissolves out hexame?yl5am91 leav+ insoluble sodium citrate4 ,z ! use ( ! solv5t1 *lor(orm1 w\ld seem to preclude decomposition ( su* a hypo!tical comp\nd z 8hexame?yl5am9-sodium-citrate10 ! extraction ( hexame?yl5am9 f ,=murol may be tak5 to demon/rate its pres5ce 9 ! free /ate4 ,t ,=murol is n a comp\nd ( hexame?yl5am91 b a mixture ( hexame?yl5am9 & sodium citrate1 0 fur!r indicat$ by ! appe>ance ( ! cru%$ tablets describ$ above4 ,fur!r1 on ! l[-p[] microscope ! p[d] 0 f\nd to be compos$ ( transp>5t cry/als & :ite opaque p>ticles :i* appe>$ to be masses ( m9ute cry/als4 ,:5 treat$ ) *lor(orm ! transp>5t cry/als dissolv$1 leav+ ! :ite masses intact1 demon/rat+ ! pres5ce ( two di/9ct sub/ances1 "o soluble & ! o!r insoluble 9 *lor(orm4 ,x hav+ be5 demon/rat$ t ! residue obta9$ by evaporation ( *lor(orm c\ld n be weigh$ z hexame?yl5am91 due to enclos$ *lor(orm1 ! am\nt ( ?is sub/ance 9 ! residue 0 det]m9$4 ,! me?od us$ has be5 describ$ 9 ! ,report ( ! ,*emical ,laboratory ( ! ,am]ican ,m$ical ,association1 ,vol4 ,i1 p4 #ee1 & dep5ds on ! decomposition ( hexame?yl5am9 by means ( sulphuric acid to =m ammonium sulphate & =maldehyd4 ,f ?is solution ! ammonia is lib]at$1 di/ill$ & det]m9$ by titration & f ! ammonia f\nd ! am\nt ( hexame?yl5am9 is calculat$4 ,by ?is me?od ,=murol 0 f\nd to conta9 7a7 #ce4db p] c5t4 & 7b7 #ce4cb p] c5t41 or an av]age ( #ce4cg p] c5t4 hexame?yl5am94 ,! residue insoluble 9 *lor(orm 0 %[n to consi/ ess5tially ( disodium hydrog5 citrate by det]m9+ ! am\nt ( sodium 7,na7 conta9$ 9 ,=murol4 ,! p]c5tage ( sodium calculat$ f ! am\nt ( sodium sulphate f\nd 0 7a7 #aa4ch p] c5t4 & 7b7 #aa4bj p] c5t41 or an av]age ( #aa4bi p] c5t41 equival5t to #fb4ej p] c5t4 disodium hydrog5 citrate4 ,z a *eck on ?is det]m9ation1 ! am\nt ( mat]ial conta9$ 9 ,=murol :i* is insoluble 9 *lor(orm 0 det]m9$4 ,x 0 f\nd to be 7a7 #fc4bc p] c5t4 & 7b7 #fc4di p] c5t41 mak+ an av]age ( #fc4cf p] c5t41 & ?us agree+ fairly well ) ! results obta9$ :5 ! sodium cont5t 0 assum$ to be disodium hydrog5 citrate4 ,f ?is analysis x appe>s t ,=murol is n a def9ite comp\nd ( hexame?yl5am9 & sodium citrate1 b in/ead is a mixture ( ^! sub/ances consi/+ approximately ( hexame?yl5am9 #ce4cg p] c5t4 & sodium acid citrate 7disodium hydrog5 citrate7 #fc4cf p] c5t41 practically a mixture ( #a "p hexame?yl5am9 & #b p>ts sodium acid citrate4 ,^! results agree ) ^? report$ by ,z]nik#dg & %[ t ! product n[1 z !n1 is n true to claims4 #dg ,!rap4 d4 ,geg5w41 ,febru>y1 #aiji4 ,9 view ( ! f9d+s ( ! laboratory1 x is recomm5d$ t ,=murol be refus$ recognition4 ,z ! exploitation ( well-kn[n rem$ies "u false & mislead+ names is detrim5tal to ! progress ( m$ic9e1 x is recomm5d$ t publication ( ?is report be au?oriz$4 ,editorial ,note3 ,?is report illu/rates once m ! value ( ! ,c\ncil on ,ph>macy & ,*emi/ry & ! ,*emical ,laboratory to ! m$ical pr(ession4 ,be=e ! ,c\ncil 0 organiz$ !re 0 no ag5cy to protect ! physician's int]e/s 9 ! matt] ( ph>maceuticals4 ,"u ! old rgime ,=murol w\ld h be5 h]ald$ z a new 8syn!tic0 ( ! mo/ approv$ made-9-,g]many type--& ! claims w\ld h gone un*all5g$4 ,to-day its /atus is made cle> & ! pr(ession is in=m$4 ,only ^? :o h closely /udi$ ! "q c realize :at a wond]ful p[] = comm]cial probity ! ,c\ncil has prov$4 ,"u ! laissez faire sy/em ( ! pa/1 _m l>ge ph>maceutical firms gave little att5tion to ! accuracy ( ! claims made = _! products4 ,if ! adv]tis+ gave good 8pull+0 results1 t 0 all t 0 ask$ or expect$4 ,)9 ! pa/ five ye>s a wond]ful *ange has tak5 place 9 ?is reg>d1 & firms ( ! bett] class h s modifi$ _! adv]tis+ z to make x n only cons]vative 9 tone1 b to approximate sci5tific accuracy4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #ba1 #aiaa47 ,,ga/rog5 ,,tablets ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,bri/ol-,my]s ,co41 ,brooklyn1 ,n4 ,y41 sells ,ga/rog5 ,tablets :i* are describ$ z 8,a ,neutraliz+ ,dige/ive0 to be 8us$ 9 connection ) ,sal ,hepatica40 ,sal ,hepatica1 x w be rememb]$1 is ano!r product ( ! ,bri/ol-,my]s ,company & has be5 ! subject ( previ\s unfavorable comm5t4 ,! label on a rec5tly pur*as$ package ( ,ga/rog5 ,tablets conta9s ! foll[+3 8,= ga/ric di/ress1 weak /oma* & dyspepsia1 "o to two tablets aft] eat+2 repeat 9 half an h\r if ne$$4 8,also indicat$ 9 nausea1 flatul5ce1 s\r /oma* & he>tburn40 ,:ile ^! recomm5dations s\nd z if !y 7 address$ to ! public1 ,ga/rog5 ,tablets are adv]tis$ 9 m$ical publications & h5ce come )9 ! scope ( ! ,c\ncil4 ,ga/rog5 ,tablets are said to be compos$ ( peps91 calcium c>bonate1 calcium phosphate & 8aromatics40 ,z ea* tablet1 accord+ to ! label1 conta9s #g gra9s ( calcium c>bonate 7*alk71 ! recomm5d$ dosage w\ld 9 mo/ cases be suffici5t to neutralize ! ga/ric fluids 9 ! /oma* & w\ld ?us t5d to prev5t ! peps9 f ex]t+ its dige/ive effects4 ,! means adopt$ to relieve "o symptom ( dyspepsia1 9 o!r words1 defeats ! action ( ! means = reliev+ ! indige/ion4 ,! fact is t pati5ts :o ne$ an antacid d n ne$ peps91 :ile ^? :o ne$ peps9 w be h>m$ by ! adm9i/ration ( an antacid4 ,ga/rologi/s hold t1 except 9 r>e cases1 ! evid5ce t5ds to %[ t :]ev] !re is a suffici5cy ( hydro*loric acid !re is a suffici5cy ( peps94 ,:5 peps9 is lack+ x %\ld be adm9i/]$ along ) hydro*loric acid to make x effective4 ,! ,c\ncil vot$ t ,ga/rog5 ,tablets be refus$ recognition4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,dec4 #ab1 #aiad47 ,,glyco-,,h]o91 ,,smi? ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! foll[+ report 0 submitt$ to ! ,c\ncil by a ref]ee & publication au?oriz$4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,glyco-,h]o91 ,smi? 7,m>t9 ,h4 ,smi? ,co41 ,new ,york7 is m>ket$ 9 a %[y 8pat5t-m$ic9e0 type ( package1 ! label on :i* ann\nces ! pres5ce ( #a_/b gra9 ( h]o9 to ! fluid\nce & admits ! pres5ce ( #c4e p] c5t4 alcohol1 an active +r$i5t t is n discuss$ 9 any way 9 ! lit]ature s5t out by ! manufactur]4 ,! composition ( ,glyco-,h]o91 ,smi?1 is giv5 z foll[s3 8,ea* teaspoonful repres5ts3 ,h]o9 #a_/af gra91 ,:ite ,p9e ,b>k #c-a_/b gra9s1 ,ammonium ,hypophosphite #c gra9s1 ,balsam ,tolu #a_/d gra91 ,hyoscyamus #a gra91 ,glyc]9 ,q4 ,s40 ,! alcohol is n m5tion$ 9 ! =mula4 ,! adv]tis+ matt] says ( ! m]its ( ! =mula3 8,despite ! fact t h]o91 :i* is univ]sally recogniz$ z an invaluable respiratory s$ative1 is a conspicu\s elem5t ( ,glyco-,h]o91 ,smi?1 ! o!r con/itu5ts1 h5bane1 ammonia hypophosphite1 balsam tolu & :ite p9e b>k are factors ( no less importance2 inde$1 x is ?r\gh ! conc]t$ action ( its sev]al +r$i5ts t ! prep>ation proves s notably b5eficial 9 ! class ( affections 9 :i* x is indicat$4 ,! con/antly increas+ popul>ity ( ! prep>ation 9 ! treatm5t ( respiratory affections is ! be/ adducible evid5ce ( its value 9 su* disord]s40 ,! absurdity ( ?is ass]tion w be appreciat$ on comp>+ ! nature1 quantities & activities ( ! sev]al +r$i5ts4 ,?us1 :ile h]o91 a pot5t habit-=m+ drug1 is pres5t 9 unusually l>ge proportions1 tolu1 an innocu\s or comp>atively h>mless product1 is said to be repres5t$ by #a_/d gra91 a relatively small quantity1 h>dly suffici5t to imp>t ev5 a di/9ctive ta/e or flavor4 ,ammonium hypophosphite1 9 ! am\nt said to be pres5t1 may be consid]$ to be practically useless1 :ile ! dose ( hyoscyamus1 an additional n>cotic1 is fairly l>ge4 ,! :ite p9e b>k pres5t is probably z active z w\ld be a correspond+ am\nt ( :ite p9e %av+s or ( turp5t9e suffici5t to give ! prep>ation a slight odor4 ,! vehicle1 glyc]91 is claim$ to be 8notably advantage\s10 b n a ^w occurs 9 ! discussion by ! manufactur] 9 reg>d to ! pres5ce ( alcohol1 :i* is c]ta9ly q z active m$ic9ally z ! balsam ( tolu & contributes fully z mu* to ! flavor or ta/e ( ! prep>ation z does ! :ite p9e b>k4 ,9 prom95t type on ! out] label ( ! trade package we are told t ! prep>ation is int5d$ = ! treatm5t ( 8,,c\gh1 ,,a/hma1 ,,ph?isis1 ,,pneumonia1 ,,bron*itis1 ,,l>yngitis1 ,,:oop+-,,c\gh ,,& ,,k9dr$ ,,infections40 ,9 mu* small] type3 8,glyco-,h]o9 7,smi?7 is di/9ctly a product design$ expressly = ! use ( physicians40 ,! circul> includ$ ) ! trade package1 h[ev]1 be>s /atem5ts :i* w\ld t5d to enc\rage self-drugg+ by ! layman1 & 9 view ( ! mann] 9 :i* ! prep>ation is exploit$ are und\bt$ly int5d$ to d s4 ,= in/ance3 8,bron*itis4--,9 ! acute =m ( bron*itis1 ,glyco-,h]o9 7,smi?7 acts mo/ happily4 ,x t5ds to dim9i% ! conge/ion & inflammation ( ! l9+ ( ! air passages1 relieves ! pa9 & in/itutes repair4444 8,ph?isis4--,9 ! treatm5t ( ! c\gh ( ph?isis1 ,glyco-,h]o9 7,smi?7 is us$ ) ! mo/ gratify+ results4 ,x *ecks ! night sweats1 acts favorably ^u ! reflexes1 increases expectoration & induces refre%+ sleep4 8,a/hma4--,! prep>ation dim9i%es ! int5sity ( ! p>oxysms & l5g!ns ! int]vals betwe5 _! recurr5ce4 ,by ! adm9i/ration ( ! prep>ation1 a/hmatic attacks c frequ5tly be abort$4 8,pneumonia4--,9 ! initial /age ( pneumonia1 ! prep>ation ex]cises a calm+1 antipyretic & s$ative effect4 ,9 ! latt] /ages ( ! disease1 ! analgesic & expectorant prop]ties ( ! product are well display$4 8,:oop+-,c\gh4--,adm9i/]$ 9 doses ( f five to t5 drops ?is prep>ation af=ds surpris+ly satisfactory results4 ,! c\gh rapidly loses its spasmodic "* & ! frequ5cy ( ! p>oxysms is consid]ably dim9i%$40 ,h[ cruelly mislead+ ! lit]ature put out by ! manufactur] ( ?is no/rum is1 w be app>5t f a comp>ison ( ! r l>ge dose ( h]o9 9 a teaspoonful ( ! no/rum & ! directions on ! package t3 8,! adult dose ( ,glyco-,h]o9 7,smi?7 is "o teaspoonful repeat$ e two h\rs or at long] int]vals1 z ! case may require4 8,*ildr5 ( #aj or m ye>s1 f a qu>t] to a half-teaspoonful4 8,*ildr5 ( #c ye>s or m1 #e to #aj drops40 ,a ,,wick$ ,,falsehood ,includ$ 9 mu* ( ! adv]tis+ matt] t has be5 put out is ! b>e-fac$ untru? t ! prep>ation does n produce n>cotism or habituation4 ,"h is a quotation f an undat$ circul>3 8,glyco-,h]o9 7,smi?7 is decid$ly pref]able to prep>ations conta9+ code9e or morph9e1 by reason ( ! fact t x does n produce n>cotism1 con/ipation1 ga/ric di/urbance nor habituation1 ev5 ?\gh its adm9i/ration be protract$40 ,t ?is ass]tion is n 9 keep+ ) facts is evid5c$ by ! rec5t report ( a /udy on ! sale & use ( h]o9 made by ! ,u4 ,s4 ,dep>tm5t ( ,agriculture4 ,f ! in=mation ga!r$ x appe>s t ! sales ( h]o9 & h]o9-conta9+ prep>ations h increas$ greatly1 p>ticul>ly 9 ^? /ates :i* h rigid laws prev5t+ ! indiscrim9ate sale ( morph9 & coca94 ,inve/igation ( ! subject e/abli%es ! fact t _m drug victims :o =m]ly us$ morph9 & coca91 & :o "u ! new laws f9d x difficult to obta9 ^! sub/ances1 h begun us+ h]o91 ! sale ( :i* is n z yet c>efully re/rict$ "u /ate laws4 ,! drug is said to be fully z dang]\s z morph91 & by _m is held to be mu* worse1 = ! reason t x occasionally kills ! victim outright1 & its habitual use is f> h>d] to ov]come ?an t ( o!r drugs4 ,phillips1#dh 9 discuss+ ! preval5ce ( ! h]o9 habit1 reports1 among o!rs1 ! case ( a physician ag$ #fj :o began to take h]o9 because he suff]$ f a *ronic c\gh & ?\ght !re 0 no dang] ( habit f ! use ( ?is drug because he believ$ ! /atem5ts ( v>i\s manufactur+ firms :o claim$ t !re 0 no dang] ( habit4 #dh ,phillips1 ,john3 ,preval5ce ( ! ,h]o9 ,habit1 ,! ,j\rnal ,a4 ,m4 ,a41 ,dec4 #ad4 #aiab1 p4 #badf4 ,9 a pamphlet n[ be+ di/ribut$ to ! m$ical pr(ession1 entitl$1 8,glyco-,h]o9 7,smi?71 an exposition ( its compon5ts toge!r ) ref]5ces to its value 9 ! treatm5t ( ,bron*itis1 ,c\gh1 ,c\gh ( ,ph?isis1 ,l>yngitis1 ,pneumonia & alli$ disord]s ( ! ,respiratory ,tract10 ! sev]al alleg$ uses ( ! no/rum 9 ! treatm5t ( c\gh1 8,reg>dless ( ! nature ( its und]ly+ cause1 444 :e!r ( rec5t orig9 or ( long duration10 are discuss$ at l5g?1 & em95t practition]s ) degrees ext5d+ ! wid? ( ! pr9t$ page are quot$ 9 support ( ! /atem5ts made4 ,:ile x may be p]missible = a !oretically tra9$ m$ical tyro :o lays claim to ! "r ( app5d+ ! abbreviations ,m4,a41 ,m4,d41 ,d4,c4,l41 ,l4,r4,c4,p4 to 8 "n to laud a het]og5e\s habit-=m+ c\gh-syrup l ,glyco-,h]o91 ,smi?1 simil> te/imonials f a man entitl$ to app5d ,ph4,g41 ,m4,s41 ,m4,d4 to 8 "n makes "o d\bt ! value ( ! tra9+1 ei!r sci5tific1 ph>maceutical or m$ical1 t has be5 giv5 ! poor un=tunate :o1 accord+ to 8 own /atem5ts1 indiscrim9ately doses a female pati5t ( #g & a male pati5t ( #dj ) huge doses ( h]o9 e two1 f\r or six h\rs4 ,! dang] ( contribut+ to ! spread ( ! h]o9 habit by ! use ( prep>ations ( ?is type is indicat$ by an editorial 9 ,! ,j\rnal ( ! ,am]ican ,m$ical ,association1#di :i* po9ts out t al?\gh h]o9 & its hydro*lorid h be5 9 use b a few ye>s !y h already e/abli%$ !mselves among ! habit-=m+ drugs & h become suffici5tly conspicu\s 9 ?is respect to awak5 ! ?9k+ public to ! deplorable results = :i* !y may become responsible4 ,phillips1#a 9 ! article m5tion$ above1 quotes ,petty1 :o reports t 9 ! la/ #aej cases ( drug habit com+ "u 8 c>e he saw eight cases ( h]o9 addiction4 ,?ree ( ^! 7 initial cases2 9 "o ! pati5t _h be5 cur$ ( ! opium habit1 b foll[+ an op]ation h]o9 0 prescrib$1 & ! habit foll[$4 ,! rema9+ f\r pati5ts purposely sub/itut$ h]o9 = morph91 to :i* !y _h be5 addict$4 #di ,facts ab\t ,h]o91 ,curr5t ,comm5t1 ,! ,j\rnal ,a4 ,m4 ,a41 ,dec4 #ba1 #aiab1 p4 #bbfb4 ,,! ,,gr[? ,,( ,,h]o9 ,,addiction ,! imm95t dang] ( sub/itut+ h]o9 = ei!r morph9 or coca9 is %[n by ! fact1 report$ by ! ,u4 ,s4 ,dep>tm5t ( ,agriculture1 t dur+ ! e>ly mon?s ( #aiac ! coron]'s (fice 9 ,philadelphia ,c\nty1 ,pa41 held inque/s on five sudd5 dea?s f h]o9 poison+4 ,9 ea* case ! victim 0 a h]o9 fi5d & took an ov]dose4 ,drug fi5ds are app>5tly able to consume relatively l>ge quantities ( morph9 or coca91 b any sudd5 & mat]ial increase 9 ! am\nt ( h]o9 tak5 is liable to prove fatal4 ,z indicat+ ! wide sale ( ?is sub/ance1 x is kn[n t "o druggi/ 9 ,p5nsylvania ^: /ore is locat$ 9 an undesirable section ( 8 city has be5 buy+ h]o9 tablets 9 #be1jjj lots4 ,,glyco-,,h]o91 ,,smi?1 ,a 8,,pat5t ,,m$ic9e0 ,! popul>ity ( ,glyco-,h]o91 ,smi?1 z a h\sehold no/rum is sugge/$ by ! fact t "o ( ! l>g] dep>tm5t-/ore type ( drug-/ores 9 ! city ( ,philadelphia li/s ?is prep>ation 9 its 8pat5t-m$ic9e0 catalogue at #a4ge p] bottle & sells x freely to all :o c>e to buy4 ,?is is due to ! fact t ,p5nsylvania1 l _m o!r /ates1 does n include h]o9 9 ! prohibit$ li/ ( habit-=m+ drugs t c be suppli$ only on physicians' prescriptions4 ,to :at ext5t ,glyco-,h]o91 ,smi?1 is responsible = develop+ ! rapidly gr[+ h]o9 habit is ( c\rse problematic4 ,x is reasonable1 h[ev]1 to suppose t a prep>ation1 ea* teaspoonful ( :i* conta9s s l>ge a dose ( h]o9 z does ?is no/rum1 :5 tak5 z repeat$ly & z indiscrim9ately z is direct$ by ! manufactur]1 w\ld (f] possibilities = h>m suffici5t 9 numb] to induce ! ?9k+ m$ical practition] to avoid its use altoge!r & at lea/ to sugge/ to ev5 ! mo/ comm]cial dabbl] 9 ! heal+ art ! desirability ( c>efully consid]+ its pot5cy = h>m be=e endors+ its use 9 ! treatm5t ( 8c\gh & k9dr$ affections40--7,f ! ,j\rnal ,a4 ,m4 ,a41 ,june #f1 #aiad47 ,,glyco-,,?ymol9e ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil1 hav+ vot$ t ,glyco-,?ymol9e be refus$ recognition1 au?oriz$ publication ( ! foll[+ report4 ,w4 ,a4 ,puckn]1 ,secret>y ,glyco-,?ymol9e 7,kress & ,ow5 ,company1 ,new ,york7 is a typical example ( a 8pat5t m$ic9e0 adv]tis$ to ! public ?r\gh ! doctors4 ,bottles ( ! mixture ) ! "n bl[n 9 ! glass are issu$ to physicians = di/ribution to pati5ts1 & ! circul> :i* comes ar\nd ! bottle m or less directly recomm5ds x = use 9 almo/ e =m ( infecti\s disease4 ,,composition ,,& ,,v>y+ ,,=mulas ,diff]5t =mulas = ,glyco-,?ymol9e h appe>$4 ,at "o "t x 0 said to conta93 8,sodium #bd1 ,boric ,acid #d1 ,b5zo9 #d1 ,acid ,salicylic #j4cc1 ,eucalyptol #j4cc1 ,?ymol9e #j4ag1 ,betula ,l5ta #j4jh1 ,m5?ol #j4jh1 ,p9i ,pumilionis #j4ag1 ,glyc]9 & solv5ts1 q4s40 ,ano!r =mula1 :i* appe>$ ab\t ! same "t1 03 8,b5zo-,salicyl4 ,sod4 #cc4cc1 ,eucalyptol #j4cc1 ,?ymol #j4ag1 ,salicylate ( ,me?yl f ,betula ,l5ta #j4af1 ,p9i ,pumilionis #j4ag1 ,glyc]9 & solv5ts q4s40 ,a lat] =mula 0 l ! second except t x includ$ 8,m5?ol1 #j4jh40 ,analysis 9 ! *emical laboratory ( ! ,am]ican ,m$ical ,association %[$ t ,glyco-,?ymol9e conta9$ borax1 b no boric acid2 sodium salicylate1 b no salicylic acid2 sodium b5zoate1 b no b5zo92 ! comp\nd b5zo-salicyl4 sod4 c\ld n be det]m9$1 b a mixture ( sodium b5zoate & sodium salicylate 0 demon/rable4#ej ,lat] ,puckn] po9t$ out#ea t :ile su* a comb9ation z b5zo-salicylate ( sodium is kn[n1 x c\ld n possibly be pres5t 9 ,glyco-,?ymol9e because ! alkal9ity ( ?is mixture w\ld decompose ! comp\nd4 ,z ! manufactur]s evid5tly recognize t false =mulas c no long] be made plausible1 only vague /atem5ts z to ! composition are n[ (f]$4 #ej ,! ,=mula = ,glyco-,?ymol9e1 ,ph>macology ,dep>tm5t1 ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #i1 #aiji1 p4 #adg4 #ea ,puckn]1 ,w4 ,a43 ,rep4 ,*em4 ,lab41 ,a4 ,m4 ,a41 #aiaj1 iii1 #g4 ,two po9ts %\ld be not$ 9 ?is connection3 #a4 ,glyco-,?ymol9e conflicts ) ,rule #a ( ! ,c\ncil on ,ph>macy & ,*emi/ry1 :i* decl>es t no article %all be accept$ = inclusion ) ,new & ,non(ficial ,rem$ies unless its composition be furni%$4 #b4 ,no matt] :i* publi%$ =mula be accept$ z correct1 x is at be/ a weak antiseptic4 ,! antiseptic +r$i5ts pres5t _c act z g]micides 9 ! /r5g? 9 :i* !y are us$1 or 9 ! alkal9e solution on ! unique virtues ( :i* ! circul> lays s mu* /ress 78! "o antiseptic solution bas$ on ! alkal9ity & sal9e /r5g? ( normal blood074 ,z %[n by ,v]hoeff & ,ellis1#eb undilut$ ,glyco-,?ymol9e does n kill ,/aphylococcus aureus 9 f\r h\rs4 ,x evid5tly1 !y say1 8c\ld h b little if any great] !rapeutic value ?an /]ile salt solution40 #eb ,v]hoeff1 ,f4 ,h41 & ,ellis1 ,edw>d ,kei?3 ,! ,bact]icidal ,values ( ,"s ,widely ,adv]tis$ ,antiseptics1 ,! ,j\rnal ,a4 ,m4 ,a41 ,june #bi1 #aijg1 p4 #bage4 ,,dang]\s ,,recomm5dations ,9 ,diph!ria3 8,case-reports0 9 ! adv]tis+ pamphlet describe ! treatm5t ( diph!ria ) ,glyco-,?ymol9e4 ,x is surely unnecess>y to po9t out t1 :atev] ! possible m]its ( ,glyco-,?ymol9e or its +r$i5ts1 !y are utt]ly irrelevant "h4 ,b let a 8case-report0 be quot$3 844444444444441 ,m4,d41 /ates3 #8,i h _m an int]e/+ /ory ( ,glyco-,?ymol9e4 ,i j f9i%$ up a family 9 :i* ,i 0 treat+ five cases ( diph!ria--two ( :i* pres5t$ diph!ritic membrane 9 nasal cavity4 ,i decid$ n to use antitox9 9 ^! cases4 ,i us$ only ! regul> con/itutional treatm5t & ,glyco-,?ymol9e z a local antiseptic4 ,i believe ! ,glyco-,?ymol9e work$ wond]s4 ,my cases are all n[ 9 good heal?1 ) no aft] tr\bles4 ,i ?9k x an ideal antiseptic = e tr\ble 9 nose & ?roat4'0 ,words ( d5unciation fall flat be=e ! complac5t self-revelation ( ! physician :o 8decid$ n to use antitox940 ,surely if any o!r physicians h be5 misguid$ by ?is example1 !re mu/ be _m ano!r 8int]e/+ /ory ( ,glyco-,?ymol9e0 to tell--n to speak ( o!r families t h be5 8f9i%$ up40 ,9 ,oph?almia ,neonatorum3 ,we ga9 f ! same adv]tis+ pamphlet ! foll[+ in=mation on prophylaxis3 8,! treatm5t 9 ! pa/ has consi/$ ( in/illation ( silv] nitrate1 boric acid1 salts ( m]cury1 nucle9at$ salts ( silv] & m]cury1 etc4 4441 b ^! ag5ts h prov$ to be failures z an absolute specific4444 ,dur+ ! pa/ few mon?s exp]im5ts h demon/rat$ ! efficacy ( a new mode ( treatm5t t is bo? rapid & ?or\gh1 & devoid ( dang] 9 its use4 ,?is me?od consi/s ( ?or\gh irrigation ( ! eyes 9 fully develop$ cases ( ! disease ) a solution ( ,glyco-,?ymol9e40 ,at ! v be/1 ,glyco-,?ymol9e is a weak1 a v weak antiseptic--n a g]micide4 ,to ass]t1 or ev5 to imply1 t x is sup]ior to ! well-tri$ & efficaci\s ,cr$ me?od ( treatm5t = oph?almia 9 ! new-born is cruelly wick$4 ,9 ,consumption3 ,?is f ! same pamphlet3 8,! indiff]5ce ( ph?isical pati5ts t[>d ! ma9t5ance ( sanit>y conditions is prov]bial4 8,t ! environm5t ( all su* pati5ts %\ld be absolutely aseptic bo? = ! good ( ! pati5t & = ! welf>e ( ^? :o are br\ght into contact ) !m is a well-e/abli%$ fact40 ,x is1 in/ead1 an ill-e/abli%$ fiction4 ,to talk ab\t ma9ta9+ an 8absolutely aseptic0 environm5t "u any practical conditions ( daily life is to talk nons5se2 ! ?+ is impossible1 ev5 7 x desirable4 ,b1 n to be di/ract$ f ! ma9 issue by subsidi>y falsehoods3 8,9 ,glyco-,?ymol9e we h an antiseptic :i*1 :ile mild & soo?+ 444 is /ill a p[]ful ag5t = promot+ asepsis1 & a pot5t factor 9 ! ma9t5ance ( sanit>y environm5t 9 ! sick room4 8,inhal$ f a vaporiz] or a f9e spray atomiz]1 x w loos5 ! mucus 9 a m>vel\s mann] & 9 a wond]fully %ort "t1 %ort5 ! p>oxysms ( c\gh+ to a m>k$ degree1 at ! same "t r$uc+ ! dang] ( contagion to a m9imum40 ,& ?is is ! prep>ation1 x w be rememb]$--?is 8p[]ful ag5t = promot+ asepsis0--:i*1 :5 appli$ 9 undilut$ /r5g?1 0 unable to kill ,/aphylococcus aureus 9 f\r h\rs6 ,x w\ld be a wa/e ( space to cite fur!r evid5ce to %[ t ! adv]tis+ ( ,glyco-,?ymol9e is 9 conflict ) ,rule #f ( ! ,c\ncil1 :i* provides t no article %all be accept$ 8conc]n+ :i* ! manufactur] or 8 ag5ts make unw>rant$1 exagg]at$ or mislead+ /atem5ts z to ! !rapeutic value40 ,x is fur!r 9 conflict ) ,rule #d1 aga9/ indirect adv]tis+ by means ( ! label1 package or circul> accompany+ ! package4 ,,claims ,,to ,,orig9ality ,hat*] & ,wilb]t h po9t$ out t f a !rapeutic po9t ( view ! composition ( ,glyco-,?ymol9e is bas$ on ! =mula ( ! widely kn[n 8comp\nd solution ( sodium borate10 or ,dobell's solution4 ,= ! ph5ol 9 ! orig9al1 a mixture ( antiseptic acids & volatile oils has be5 sub/itut$4 ,,summ>y ,glyco-,?ymol9e is 9 conflict ) ,rules #a & #d ( ! ,c\ncil on ,ph>macy & ,*emi/ry1 because ( its indef9ite composition & ! me?od ( adv]tis+ x to ! public4 ,x is 9 conflict ) ,rules #aj1 #f & #h1 9 t x is an unsci5tific1 %ot-gun mixture sold "u unw>rant$ !rapeutic claims & "u a mislead+ "n4 ,altoge!r x mu/ be consid]$ an unsci5tific het]og5e\s mixture1 9 :i* a few valuable +r$i5ts are hidd5 by ! useless %rubb]y :i* surr\nds !m4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,oct4 #aj1 #aiad47 ,,glycozone ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry1 ) ,comm5ts ,a numb] ( specim5s ( ,glycozone pur*as$ 9 ! op5 m>ket 7 exam9$ by a subcommittee4 ,! product 0 f\nd to be a mixture ( approximately #ij p] c5t4 glyc]91 #e p] c5t4 glyc]ic acid1 a small am\nt ( wat] & traces ( undet]m9$ matt]4 ,! abs5ce ( hydrog5 p]oxid or o!r p]oxids 0 demon/rat$4 ,9 its report ! subcommittee held t3 7#a7 ,! "n ( ! product is objectionable & mislead+2 7#b7 ! /atem5ts made 9 reg>d to its composition also are mislead+2 7#c7 ! claims = its !rapeutic value are exagg]at$ & untrue4 ,s9ce ! objectionable /atem5ts h be5 giv5 wide publicity among physicians z well z among ! laity1 ! subcommittee recomm5d$ t att5tion %\ld be call$ to ! matt] 9 ,! ,j\rnal4 ,! report ( ! subcommittee 0 adopt$ by ! ,c\ncil4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,comm5t3--,:ile ! "n gives ! impression t ozone or "s simil> sub/ance is an ess5tial con/itu5t ( ,glycozone1 or else t ! prep>ation is a comp\nd or d]ivative ( ozone1 & :ile ! e>li] adv]tisem5ts /at$ t ,glycozone 0 8glyc]9e comb9$ ) ozone10 ! exam9ation made by ! ,c\ncil %[s t !re is no basis ( fact = su* inf]5ces4 ,9 ! adv]tisem5ts ! 8*emical =mula0 ,c#c;,h#f,o#d ,c#c;,h#h,o#c appe>s "u ! ^w ,glycozone4 ,f ! ,c\ncil's report x is app>5t t ,c#c;,h#f,o#d /&s = glyc]ic acid & ! ,c#c;,h#h,o#c = glyc]91 & t ^!1 !re=e1 indicate ! *ief con/itu5ts ( ,glycozone4 ,few1 d\btless1 w\ld recognize ! fir/ =mula z be+ t ( a glyc]ic acid1 a product practically unkn[n 9 m$ic9e1 nor w\ld _m associate glyc]9 ) ! second4 ,! evid5t int5t is t physicians %\ld accept ! =mula z a badge ( respectability4 ,accord+ to ! label on a trade package1 ,glycozone is 8prep>$ only by ,*>les ,m>*&1 *emi/10 & is 8an absolute cure = dyspepsia1 cat>rh ( ! /oma*1 ulc] ( ! /oma*1 he>t-burn10 etc4 ,! label fur!r reads3 8,?is rem$y is positively h>mless4 ,by de/roy+ ! microbian elem5t 9 ! /oma* x prev5ts ! f]m5tation ( food & /imulates dige/ion40 ,an exam9ation ( m$ical lit]ature fails to reveal any basis = ^! claims4 ,:ile glyc]9 possesses "s antiseptic prop]ties1 x is evid5t t ! glyc]9 :i* con/itutes #ij p] c5t4 ( ?is rem$y is n ! ag5t t gives ! glycozone su* ph5om5al virtues4 ,g5]al lit]ature conta9s no?+ t w\ld indicate t glyc]ic acid 9 any quantity1 ) or )\t glyc]91 possesses ^! miracul\s prop]ties4 ,if by 8microbian elem5t0 is meant microbic organisms1 ! /atem5t is )\t f\ndation4 ,!re is no?+ 9 ?is product :i* possesses ^! bact]icidal p[]s4 ,! circul> :i* accompani$ a trade package envelops ! prep>ation 9 an air ( my/]y4 ,d]ivation f1 or close relation to1 ozone & hydrog5 p]oxid is vaguely h9t$ at1 )\t def9ite ass]tion4 ,?us1 ! *ief !rapeutic prop]ties ( glycozone & hydrozone are comp>$ z foll[s3 8,hydrozone in/antly de/roys ! microbian elem5t1 leav+ ! tissues b5ea? 9 a heal?y condition40 8,glycozone acts m sl[ly1 b n less c]ta9 z a /imulant to heal?y granulations40 ,illu/ration3 ,mu*-r$uc$ photographic reproduction ( "o ( ! old] ,glycozone adv]tisem5ts4 ,att5tion is direct$ to ! false claim t ?is no/rum is 8glyc]9 comb9$ ) ozone40 ,!re is no simil>ity betwe5 ! action ( hydrozone1 :i* is a hydrog5 p]oxid prep>ation1 & glycozone1 :i* consi/s ( a mixture ( glyc]9 & glyc]ic acid4 ,! repres5tation is false & mislead+4 ,! foll[+ /atem5t1 also1 is an unw>rant$ exagg]ation ( ! facts3 8,z an int]nal m$ication 9 f]m5tation ( food1 cat>rhal & inflammatory conditions ( ! /oma*1 & inte/9al disord]s1 its action is prompt & effective1 giv+ imm$iate relief to ! pati5t40 ,! foll[+ is ano!r illu/ration ( ! vague /atem5ts made3 ,aft] ass]t+ t ,glycozone is hygroscopic & t x w det]iorate by absorption ( wat] unless securely cork$1 x is /at$ t 8,its heal+ prop]ties increase ) age40 ,:atev] my/]i\s +r$i5t !re may be pres5t 9 ?is mixture to ju/ify ! /atem5t t ! heal+ prop]ties increase ) age c only be conjectur$4 ,to humbug ! pati5t fur!r1 ! circul> advises him to use only a 8silv]1 glass or h>d rubb] spoon40--7,f ! ,j\rnal ,a4 ,m4 ,a41 ,june #e1 #aiji47 ,,g>dn]',s ,,syrup ,,( ,,hydriodic ,,acid ,report to ! ,c\ncil on ,ph>macy & ,*emi/ry ,! foll[+ report on ,g>dn]'s ,syrup ( ,hydriodic ,acid 0 submitt$ to ! ,c\ncil by a subcommittee3 ,?is product 0 fir/ tak5 "u consid]ation 9 ,febru>y1 #aijf4 ,ref]5ce to sev]al committees 0 necess>y1 on acc\nt ( ! peculi> claims = ! ph>maceutical1 & especially ! !rapeutic1 sup]iority ( ?is prep>ation4 ,at ?is "t1 z ! ,c\ncil did n h ! necess>y facilities = inve/igat+ !rapeutic claims1 ! product 0 approv$ by ! ,c\ncil4 ,s9ce ?is "t1 h[ev]1 ! manufactur]s h laid especial /ress 9 _! adv]tisem5ts on "s highly improbable claims1 /at+1 = in/ance1 t ?is ,syrup ( ,hydriodic ,acid possesses 8all ! advantages1 ) none ( ! objectionable symptoms caus$ by potassium iodid1 or o!r =ms ( iod9 m$ication40 ,to "o ) ev5 an elem5t>y k ( *emi/ry1 ! absurdity ( ?is /atem5t %\ld be evid5t4 ,! alkal9e reaction ( ! tissues makes x impossible t hydriodic acid %\ld p]si/ z su* 9 ! body4 ,9 fact1 ! iod9 mu/ circulate 9 precisely ! same =m1 :e!r adm9i/]$ orig9ally z potassium iodid or z hydrog5 iodid4 ,! qualitative id5tity ( ! !rapeutic actions is fur!r pro( ( ?is fact1 7 su* ne$$4 ,s9ce ! mo/ important objectionable symptoms ( iodid m$ication arise aft] ! absorption ( ! drugs1 & s9ce hydrog5 iodid is conc$$ to be readily absorb$1 x is evid5t t ^! symptoms mu/ be equally liable to occur ) hydrog5 iodid z ) potassium iodid1 provid$ t equival5t doses ( iod9 are adm9i/]$4 ,an app>5t diff]5ce 9 cl9ical results w\ld arise if "o drug 7 habitually giv5 9 small] doses ?an ! o!r4 ,s9ce1 h[ev]1 ! iod9 is pres5t 9 ! body 9 precisely ! same =m1 :e!r x is adm9i/]$ z a hydrog5 iodid or potassium iodid1 x is evid5t t a giv5 degree ( !rapeutic effect w\ld correspond to an id5tical t5d5cy to iodism1 :i*ev] drug 0 us$4 ,if1 z appe>s to be ! case1 ! use ( hydriodic acid is commonly re/rict$ to ^? cases 9 :i* only m9imal doses ( iod9 are requir$1 ! relative infrequ5cy1 or ev5 abs5ce ( symptoms ) su* doses w\ld n prove t ! drug itself is less apt to cause !m ?an is ! potassium salt4 ,^! facts are 9 reality self-evid5t2 b s9ce ! ,c\ncil n[ has prop] facilities = obta9+ ! views & exp]i5ces ( cl9icians1 x vot$ to submit ! /atem5t 9 "q to its /aff ( cl9ical consultants1 & to be guid$ by _! advice4 ,,op9ions ,,( ,,! ,,cl9ical ,,/aff ,! foll[+ is an epitome ( ! replies ( ! elev5 memb]s ( ?is /aff :o _h us$ ! article or :o express$ an op9ion to ! que/ions s5t out by ! ,c\ncil3 #a4 ,,qu]y3 8,d y ?9k x possible t su* a prep>ation c\ld be devoid ( ! usual effects ( iod9 prep>ations80 ,eight reply t !y consid] ?is1 a priori1 impossible2 ?ree /amp ! /atem5t z highly improbable1 b d n c>e to say t x w\ld be impossible4 ,"o ( ! correspond5ts rem>ks3 8,:ile di/9ctly tak+ ! position t "u _m conditions we mu/ accept cl9ical results :i* we f9d n expla9able by our !oretical k1 :]e ! conditions are s simple z 9 ?is case & :]e we "k t ! iod91 :e!r adm9i/]$ z hydrog5 iodid or potassium iodid1 mu/ behave 9 ! same way1 aft] absorption1 ,i believe t no prop]ly educat$ & correct ?9k+ physician c or w1 aft] due consid]ation1 fail to reject ! claims ( sup]iority made by ! proprietors ( ?is prep>ation40 #b4 ,,qu]y3 8,w\ld y consid] x necess>y to make cl9ical exp]im5ts to settle ?is "q80 ,sev5 ( ! correspond5ts consid] ?is sup]flu\s2 f\r ( ^! h _h "s exp]i5ce ) ! article4 ,f\r1 :o h n us$ ?is product1 consid] a cl9ical te/ advisable4 ,"u ,qu]y #c we discuss ! results ( su* te/s4 #c4 ,,qu]y3 8,:5 us+ ,g>dn]'s ,syrup ( ,hydriodic ,acid1 h y ev] notic$ f x any ( ! objectionable effects ( iod9 prep>ations80 ,six ( ! correspond5ts h n us$ x1 or are unc]ta9 :e!r or n !y us$ ! product made by ,g>dn]4 ,"o correspond5t rem>ks3 8,nev] us$ x4 ,repell$ by claims ( sup]iority :i* exagg]ate disadvantages ( potassium iodid & ov]look ! small am\nt ( iod9 us$ 9 ! prep>ation adv]tis$40 ,! five cl9icians :o h prescrib$ ! prep>ation report z foll[s3 #a4 ,objectionable iod9 effects 9 two cases1 bo? pati5ts be+ intol]ant ( all iod9 prep>ations4 #b4 ,has only prescrib$ x once or twice1 b ?9ks he has se5 iodism 9 "o case1 "s ye>s ago2 does n recall cle>ly4 #c4 ,no2 b has us$ ?is make v little1 & !n always 9 v small b cont9u$ doses4 #d4 ,no1 always us$ x 9 small doses4 #e4 ,yes1 sev]al cases 9 *ildr52 typical coryza1 etc41 ) doses ( ?ree drams ?ree times a day4 ,,conclusions3 ,x appe>s t typical iodism occurr$ 9 sev]al cases1 aft] doses correspond+ to #aj gra9s or less ( potassium iodid p] day1 & ?is is a r limit$ cl9ical mat]ial4 ,objectionable iod9 effects are1 !re=e1 n uncommon4 ,sev]al correspond5ts rem>k t ! relative infrequ5cy ( iodism is easily expla9able by ! fact t syrup is r>ely employ$ 9 conditions :i* dem& an active iod9 m$ication & t x is1 !re=e1 always tak5 9 small doses4 ,9 fact1 ! ma9 if n ! only po9t ( sup]iority ( ! syrup appe>s to be 9 its flavor4 ,^! cl9ical op9ions & exp]i5ces1 !re=e1 are 9 complete agreem5t ) ! judgm5t ( ! committee1 namely1 t ! !rapeutic claims made by ! manufactur]s = ?is article are exagg]at$ & mislead+4 ,,o!r ,,mis/atem5ts ,! above is by no means ! only mis/atem5t 9 ! pr9t$ matt] issu$ by ?is manufactur]4 ,9 ! publication1 8,! ,applications ( ,iod910 issu$ 9 #aijg1 !re occur ! foll[+ mislead+ /atem5ts :i*1 s9ce !y ref] to pla9ly *emical facts1 did n require submission to ! cl9ical /aff3 ,t ! adm9i/ration ( potassium iodid aft] meals greatly impairs its physiologic action 8by its *emical union ) ! v>i\s food products0 7page #ai74 ,s f> z ! committee kn[s1 potassium iodid does n comb9e ) ! food products 9 ! /oma*4 8,iodid ( potassium1 hav+ an alkal9e reaction1 neutralizes ! hydro*loric acid 9 ! ga/ric secretions1 caus+ indige/ion1 loss ( appetite & depression0 7page #ai74 ,! ,unit$ ,/ates ,ph>macopeia /ates1 "u ,potassii ,iodidum3 8,its aque\s solution is neutral or has a slightly alkal9e reaction on litmus pap]40 ,! slight occasional alkal9ity w\ld be physiologically insignificant1 & x is absurd to claim t ?is alkal9ity causes 8indige/ion1 loss ( appetite & depression40 8,! dose ( iodid ( iron is s small t ! am\nt ( iod9 conta9$ !re9 is ( little advantage0 7page #ai74 ,z a matt] ( fact1 ! ph>macopeial av]age dose 7#a c4c47 ( ! ,syrup ( ,iodid ( ,iron conta9s z mu* iod9 7#j4he gra9s7 z a teaspoonful ( ,g>dn]'s ,syrup ( ,hydriodic ,acid 7#j4hc gra9s74 8,9 hydriodic ,acid ! iod9 is 9 comb9ation ) hydrog51 "o ( ! elem5ts ( ! natural secretions ( ! body1 & is1 !re=e1 9 physiologic h>mony0 7page #ba74 ,no comm5t is ne$$4 ,x is impli$ else:]e 7page #bi7 t potassium iodid decomposes m readily1 ) ! lib]ation ( iod91 ?an does hydrog5 iodid4 ,?is is contr>y to ! prevail+ op9ion1 & w\ld require def9ite evid5ce be=e x c\ld be accept$4 ,x is also /at$ ! l>ge doses ( potassium iodid 9 syphilis are necess>y1 because ! ga/ric decomposition prev5ts complete absorption4 ,?is is c]ta9ly untrue1 = potassium iodid is absorb$ almo/ quantitatively4 ,^!1 & num]\s o!r mis/atem5ts1 con/itute violations ( ,rule #f2 & x is1 !re=e1 recomm5d$ t ,g>dn]'s ,syrup ( ,hydriodic ,acid be remov$ f ! li/ ( rem$ies approv$ by ! ,c\ncil2 x is fur!r recomm5d$ t ?is report be publi%$4 ,! ,c\ncil po/pon$ f9al action on ! report1 p5d+ its submission to ,r4 ,w4 ,g>dn]4 ,?is hav+ be5 done1 & ! reply ( ,mr4 ,g>dn] submitt$ to ! ,c\ncil1 ! above report 0 adopt$ & ord]$ publi%$4 ,w4 ,a4 ,puckn]1 ,secret>y4 7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #ad1 #aijh47 ,,hyp]ol ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,purdue ,fr$]ick ,company1 exploit]s ( ,gray's ,glyc]9e ,tonic1 h rec5tly be5 adv]tis+ to ! m$ical pr(ession a no/rum call$ ,hyp]ol4 ,! foll[+ report to ! ,c\ncil1 by ! ref]ee1 0 adopt$ & its publication au?oriz$4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,accord+ to ! label1 ,hyp]ol is 8,a ,ut]o-,ov>ian ,corrective & ,tonic40 ,! circul> accompany+ ! trade package /ates t x is3 8,indicat$ 9 all functional diseases ( wom5 su* z3 ,am5orrhea1 ,dysm5orrhea1 ,m5orrhagia1 ,metrorrhagia1 ,sub9volution1 & 9 all conditions requir+ a ut]o-ov>ian corrective & tonic40 ,f ano!r circul> we le>n t3 8,hyp]ol is a comb9ation ( ,hydra/9e1 ,alo91 ,iron1 ,apiol & ,ergot94 ,its compon5ts to a c]ta9 ext5t w indicate its action1 b ! !rapeutic effects ( ea* +r$i5t seem to be augm5t$ to an unusual degree by use 9 ?is p>ticul> comb9ation4 ,! proportions ( ea* h be5 det]m9$ by ext5sive cl9ical exp]im5tation1 & ! =mula seems to be exactly balanc$ to produce ! be/ !rapeutic effects 9 all d]angem5ts ( ! ut]o-ov>ian functions40 ,?is 8=mula0 is n v enlight5+ & a physician :o wrote = fur!r details 0 told t ,hyp]ol conta9$3 ,hydra/9 #a_/dj gr4 ,alo9 #a_/ab gr4 ,iron salts #c gr4 ,apiol 7,special7 #c ,ergot9 #a gr4 ,& excipi5ts4 ,if ?is is correct1 !n1 s f> z its active +r$i5ts are conc]n$1 ,hyp]ol is b a mixture ( well-kn[n drugs1 hav+ contradictory prop]ties4 ,accord+ to ! claims 9 ! circul> quot$ above1 x is useful bo? 9 am5orrhea & 9 m5orrhagia4 ,! mixture is z unsci5tific z x is unnecess>y4 ,x _c be adapt$ to any individual case2 :5 ergot is indicat$1 apiol w\ld naturally be contra-indicat$2 if aloes is appropriate1 hydra/is may defeat ! object s\ght4 ,x is unnecess>y because no intellig5t physician w\ld prescribe su* a comb9ation ( drugs 9 any giv5 case4 ,! claims are exagg]at$1 improbable & fooli%4 ,hyp]ol conflicts ) ! foll[+ rules ( ! ,c\ncil3 ,rule #d1 9 t /atem5ts on ! label & 9 ! circul> enclos$ ) ! trade package adv]tise x to ! public 9 ! treatm5t ( diseases4 ,rule #f1 9 t exagg]at$ & unw>rant$ claims are made = its !rapeutic qualities4 ,rule #h1 9 t ! "n ( ?is ph>maceutical mixture fails to disclose ! pot5t con/itu5ts4 ,rule #aj1 9 t x is unsci5tific4 ,x is recomm5d$ t publication ( ?is report be au?oriz$ to call att5tion to ! unsci5tific "* ( su* complex mixtures4 ,editor's ,note3 ,hyp]ol is adv]tis$ 9 ,am]ican ,m$ic9e & ! ,/4 ,paul ,m$ical ,j\rnal4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,april #ah1 #aiad47 ,,+luv9 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,a subcommittee ( ! ,c\ncil report$ t unw>rant$ claims & misrepres5tation 7 made = ,+luv9 by its manufactur]s1 ,william ,r4 ,w>n] ,co41 recomm5d$ t ! prep>ation be refus$ recognition & t ! report be submitt$ to ,w>n] ,co4 = action4 ,! report 0 submitt$ to ! firm1 & aft] wait+ "o mon? & no ackn[l$gem5t or reply hav+ be5 receiv$1 ! ,c\ncil direct$ its publication4 ,x is z foll[s3 ,,report ,,on ,,+luv9 ,+luv9 is manufactur$ by ,w4 ,r4 ,w>n] ,co41 *emi/s1 ,philadelphia1 ,pa4 ,! pr9t$ matt] conta9s num]\s claims & repres5tations ( :i* ! foll[+ are specim5s3 8,a positive specific = indige/ion1 dyspepsia & ! mo/ effective rem$y 9 ob/9ate cases ( vomit+ ( ge/ation4444 ,a specific = vomit+ 9 pregnancy 9 doses ( f #aj to #bj gra9s1 & a pot5t & reliable rem$y = ! cure ( m>asmus1 *ol]a infantum1 indige/ion1 dyspepsia1 & sick /oma* caus$ f debility ( t organ4 ,x is sup]ior to ! peps9 prep>ations s9ce x acts ) m c]ta9ty1 & effects cures :]e !y fail4444 ,! natural glyco*olic acid 9 ,+luv9 is ! active pr9ciple & ! mo/ effici5t ag5t 9 ! treatm5t ( all /oma*ic & ent]ic disord]s40 ,two samples 7 pur*as$ at diff]5t times 9 ! op5 m>ket & on exam9ation f\nd to consi/ ess5tially ( p[d]$ meat fib] mix$ ) :at appe>$ to be a membran\s tissue resembl+ ! l9+ ( a gizz>d4 ,bo? samples on be+ te/$ by ! me?od prescrib$ by ! ,u4 ,s4 ,ph>macopeia = e/imat+ ! /r5g? ( peps9 7 f\nd to possess little1 if any1 proteolytic activity4 ,9 ord] to det]m9e :e!r or n ! l9+ ( a f[l's gizz>d possesses proteolytic action1 a fre% gizz>d 0 secur$1 ! l9+ wa%$ slightly ) wat]1 !n remov$ & on us+ "o-half ( same 9 place ( peps9 z prescrib$ by ! ,ph>macopeial me?od1 x 0 f\nd to dige/ #aj grams ( album9 )9 ! "t limit4 ,peps91 :5 prop]ly kept1 does n lose its /r5g? to any mat]ial ext5t4 ,a c>eful exam9ation 0 made = ! pres5ce ( glyco*olic acid1 claim$ to be ! active pr9ciple ( ,+luv91 b its pres5ce c\ld n be e/abli%$4 ,fur!rmore1 ! anatomic relations ( ! f[l are su* z to preclude its pres5ce4 ,! above %[s t ,+luv9 does n possess ne>ly z mu* proteolytic activity z ord9>y sac*>at$ peps9 recogniz$ by ! #ahhj ,ph>macopeia1 :i* 0 prep>$ on ! basis ( dige/+ #cjj times its weight ( egg album94 ,inasmu* z no glyco*olic acid is pres5t 9 ,+luv91 x w\ld seem t sac*>at$ peps9 w\ld be f> m efficaci\s 9 treat+ ! abnormal conditions = :i* ,+luv9 is recomm5d$ 9 ! adv]tis+ circul>s4 ,fur!rmore1 ! claims made = ! prep>ation are grossly extravagant4 ,a communication f ,w>n] ,co4 has be5 receiv$ s9ce ! above report 0 adopt$1 9 :i* x is /at$3 8,! reason t previ\s lett] 0 n repli$ to 0 because we 7 desir\s ( secur+ all ! in=mation possible on ! subject4 ,s9ce t "t we h made consid]able rese>* & also made laboratory inve/igation1 & are enclos+ ! accumulat$ data ) diagram ( a "p ( ! alim5t>y canal %[+ ! esophagus1 crop & gizz>d40 ,mu* ( ! o!r matt] submitt$ is immat]ial4 ,! foll[+1 s f> z x means any?+1 seems to confirm ! correctness ( ! report ( ! ,c\ncil's ref]ee t ,+luv9 is practically devoid ( proteolytic activity3 8444 ! !rapeutic activity mu/ be due to ! bitt] prop]ty1 r ?an any proteolytic activity1 & x probably increases1 !reby1 ! functional activity ( ! /oma*1 by :i* ! normal dige/ive process is increas$4 ,+luv9 9 a #j4d p] c5t4 hydro*loric acid solution at #cg to #dj ,c4 or if mix$ ) an aque\s solution ( peps9 "u ! same conditions possesses an acrid1 bitt] ta/e & increases ! secretion ( ! saliva & ?is is practically ! same condition z :5 9 ! /oma*1 x no d\bt /imulates ! depress$ mucosa peptic gl&s & increases ga/ric solution40 ,w4 ,a4 ,puckn]1 ,secret>y4 ,,comm5ts ,! fallacies att5d+ ! use ( dige/ive f]m5ts 9 mo/ /oma* diseases h be5 previ\sly not$ 9 ,! ,j\rnal4#ec ,9 mo/ dige/ive disord]s a defici5cy ( ! dige/ive f]m5t has n be5 prov$4 ,9 cases 9 :i* peps9 is lack+1 its adm9i/ration is valueless unless x is comb9$ ) l>ge doses ( hydro*loric acid1 & x is d\btful :e!r ?is comb9ation is ei!r necess>y or conspicu\sly useful4 ,!re is1 h[ev]1 some?+ s allur+ ab\t m$ication by dige/ive f]m5ts :i* are assum$ to supply a physiologic ne$1 t s9ce _! discov]y !y h =m$ a f]tile field = ! activity ( ! manufactur] ( propriet>ies4 ,z by sci5tific laboratory te/s1 x is possible to det]m9e :e!r a giv5 prep>ation has dige/ive p[]1 ! manufactur]s ( ,+luv9 avoid ?is po9t by claim+ t ! rem$y acts1 n on ! food1 b on ! /oma* itself4 ,t rem$ies may exi/ :i* act z /imulants to ! dige/ive secretions c n be d5i$1 al?\gh at ! pres5t "t ?is p[] has n be5 satisfactorily demon/rat$4 ,! proprietors ( ,+luv91 f9d+ t proteolytic activity is n to be attribut$ to ?is prep>ation ( *ick5s' gizz>ds1 ann\nce a new !rapeutic fact 9 ! claim t 8! natural glyco*olic acid 9 ,+luv9 is ! active pr9ciple & ! mo/ effici5t ag5t 9 ! treatm5t ( all /oma*ic & ent]ic disord]s4 ,accord+ to ! report made to ! ,c\ncil !re is no glyco*olic acid 9 ?is prep>ation1 nor is x possible1 f ! anatomic arrangem5ts ( ! f[l's dige/ive app>atus1 = x to get !re4 ,by all ! te/s :i* c be appli$ to det]m9e its value ?is prep>ation is ( mu* less value 9 dige/ive disord]s ?an sac*>at$ peps91 :i* 0 discont9u$ 9 ! ,ph>macopeia because ( its inf]iority to ! o!r =ms ( ! f]m5t4 #ec ,feb4 #b1 #aijg1 p4 #dae1 & ,feb4 #i1 #aijg1 p4 #eba4 ,! repudiation1 by ! manufactur]s1 ( ! m absurd claims made = ,+luv91 %[s ! ne$ ( ma9ta9+ an attitude ( heal?y skepticism t[>d ! adv]tis$ !rapeutic virtues ( propriet>y prep>ations4 ,if a physician is dispos$ to use dige/ive f]m5ts1 he %\ld give pref]5ce to ! (ficial prep>ations1 & f]m5ts f o!r s\rces %\ld be requir$ to /& ! exact te/s :i* demon/rate ! wor?lessness ( s _m prep>ations on ! m>ket4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,july #aa1 #aijh47 ,,inte/9al ,,antiseptic ,w-,a ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil vot$ t ,inte/9al ,antiseptic ,w-,a be refus$ recognition1 & t ! publication ( ! foll[+ report be au?oriz$4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,! ,abbott ,alkaloidal ,company adv]tises 8,inte/9al ,antiseptic ,w-,a0 z 8444 ,a sci5tifically bl5d$ & physiologically adju/$ mixture1 ( ! pure sulphoc>bolates ( calcium1 sodium & z9c1 grs4 #e1 ) bismu? subsalicylate1 gr4 #a-d & aromatics40 ,?is =mula is 9 conflict ) ,rule #a 9 t x does n /ate 9 :at proportion ! sulphoc>bolates are pres5t4 ,! "n 8,inte/9al ,antiseptic ,w-,a0 is 9 conflict ) ,rules #d & #h1 s9ce x is !rapeutically sugge/ive4 ,! prep>ation is 9 conflict ) ,rules #f & #aj1 9 t exagg]at$ claims are made = x1 no evid5ce be+ submitt$ to prove ! sup]ior value ( ! mixture4 ,! mo/ s]i\s ( ^! conflicts consi/s 9 ! exagg]at$ & mislead+ !rapeutic claims4 ,! adv]tisem5ts say3 8,?is comb9ation has no equal z an antiseptic & inhibitive ag5t 9 typhoid fev]1 di>rhea1 dys5t]y10 etc4 8,num]\s clev]ly devis$ & sci5tifically con/ruct$ inte/9al antiseptics h be5 introduc$ to ! pr(ession1 b n "o ( !m has ev] rival$ = "o mom5t ^! salts 9 popul>ity40 8444 we are conv9c$ t no small %>e ( ! cr$it = ! r$uction ( ! dea? rate 9 infantile di>rheas is due to ! widespread application ( ?is g5]al me?od ( treatm5t1 associat$ ( c\rse ) ! calomel clean-out & ! regulation ( diet1 n[ kn[n to be ess5tial40 8,b ! use ( ! sulphoc>bolates is n re/rict$ to diseases ( ! alim5t>y canal1 al?\gh 9 ! summ] di>rheas1 ga/ric f]m5tation1 inte/9al indige/ion1 typhoid fev]1 dys5t]y--inde$ 9 all alim5t>y di/urbances--x is ! "o ess5tial rem$y4 ,x is also indicat$ 9 practically all infecti\s diseases40 8,typhoid ,fev] 79 ?is disease ! ,w-,a ,inte/9al ,antiseptic is ( great value2 us$ e>ly1 ) ! prop] syn]gi/ic clean\t1 x w (t5 cut %ort ! disease740 ,^! extreme claims exce$ ! limits ( p]missible optimism1 unless !y are support$ by /rong dep5dable evid5ce4 ,!y contra/ %>ply ) ! l[ e/eem 9 :i* ! ph5olsulphonates 7sulphoc>bolates7 are g5]ally held4 ,to accept ^! claims1 & to ju/ify enc\rag+ physicians to rely on !m1 x w\ld be necess>y to e/abli%3 ,fir/1 t feasible conc5trations h a di/9ct antiseptic action on cultures ( inte/9al bact]ia4 ,?is exp]im5t c\ld be easily made1 b ! claims d n seem to be bas$ on evid5ce ( ?is k9d4 ,second1 t ! prep>ation actually *ecks putrefaction 9 ! inte/9es4 ,!re are sev]al me?ods by :i* ?is pro( may be attempt$2 b ! claims d n appe> to be bas$ on evid5ce ( ?is k9d4 ,?ird1 t ! prep>ation actually has a favorable influ5ce on ! progress ( diseases4 ,?is sort ( evid5ce is expos$ to s _m fallacies t x w\ld h to be ga!r$ v c>efully & critically1 duly disc\nt+ ! effect ( o!r treatm5t2 = in/ance1 by comp>ison ) simil> cases :i* d n receive ?is prep>ation4 ,?is is especially important2 & yet we f9d directions to use ?is prep>ation 9 conjunction ) active ca?>tic treatm5t1 :i* 9 itself has consid]able influ5ce on ! conditions = :i* ?is prep>ation is recomm5d$4 ,no evid5ce ( ?is k9d is pres5t$4 ,! te/imonials conta9$ 9 ! adv]tisem5ts _c be consid]$ z s]i\s evid5ce4 ,none pres5t any indication ( accurate record or prop] control ( conditions1 or ( ! p]=mance ( control obs]vations4 ,!y are sup]ficial impressions1 to :i* little or no weight c be atta*$4 ,x is recomm5d$ t ,inte/9al ,antiseptic ,w-,a be consid]$ ineligible = ,new & ,non(ficial ,rem$ies4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,dec4 #ai1 #aiad47 ,,bann]man',s ,,intrav5\s ,,solution ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,bann]man's ,intrav5\s ,solution 7,wm4 ,bann]man & ,co41 ,*icago7 0 refus$ recognition because vague1 indef9ite & mislead+ /atem5ts 7 made reg>d+ its composition1 because x 0 recomm5d$ = anemia1 tub]culosis & syphilis "u grossly exagg]at$ & unw>rant$ claims & because ! intrav5\s injection ( complex & indef9ite mixtures is unsci5tific & dang]\s4 ,notice ( ! action ( ! ,c\ncil hav+ be5 s5t to ! ,bann]man ,company1 ! firm submitt$ a revis$ /atem5t ( composition & also a revis$ adv]tis+ circul>4 ,! claim is made t ,bann]man's ,intrav5\s ,solution 8is a comp\nd ( only ! pure/ & prov5 effici5t ,u4 ,s4 ,p4 drugs40 ,accord+ to ! late/ /atem5t3 ,ea* #aj c4c4 ( ,bann]man's ,solution conta9s3 ,hydr>gyri ,album9as ,m]cury ,cont5t #a #a-i ,gr4 or #j4jge ,gm4 ,f]ri ,album9as ,iron ,cont5t #d #a-d ,grs4 or #j4bhf ,gm4 ,sodii ,*loridum #f #a-e ,grs4 or #j4dab ,gm4 ,calcii ,salicylicum #d ,grs4 or #j4bf ,gm4 ,guaiacol #d ,grs4 or #j4bf ,gm4 ,creosote 7,bee*wood7 #e ,grs4 or #j4cb ,gm4 ,! solv5t is said to be di/ill$ wat]4 ,! =mula is unsatisfactory 9 sev]al p>ticul>s4 ,! /at$ am\nts ( "s ( ! +r$i5ts are 9 excess ( _! solubility 9 wat]2 ! nature & am\nt ( album9 conta9$ 9 ! 8,hydr>gyri ,album9as0 & 8,f]ri ,album9as0 are n giv52 ! claim t ! solution conta9s only ,u4 ,s4 ,p4 drugs is n true4 ,b ! ma9 objection to ! prep>ation is its unsci5tific "* & ! unw>rant$ !rapeutic claims made = x4 ,ev5 ?\gh a pati5t _h all ?ree diseases1 syphilis1 tub]culosis & anemia1 x w\ld be mo/ irrational to use a %otgun prescription1 conta9+1 9 fix$ unv>y+ proportions1 m]cury = ! syphilis1 iron = ! anemia & g]micides = ! tub]culosis4 ,9 syphilis ! m]cury-cont5t ( ,bann]man's ,solution is inadequate2 9 anemia ! intrav5\s adm9i/ration ( iron is unw>rant$1 & 9 tub]culosis !re is no evid5ce t ! injection ( bact]icides is effici5t4 ,exception mu/ be tak51 moreov]1 to ! /atem5t t 8its use is absolutely safe40 ,! dang] ( anaphylaxis f repeat$ injections ( album9ates _c be disreg>d$1 & z ,j4 ,f4 ,&]son1 director ( ! ,hygi5ic ,laboratory1 has po9t$ out#ed we "k little ( ! second>y or remote effects ( ! intrav5\s injection ( toxic sub/ances2 "s ( !m probably d p]man5t h>m4 #ed ,! ,j\rnal ,a4 ,m4 ,a41 ,july #d1 #aiad1 p4 #a4 ,su* claims z ! foll[+ require no comm5t3 8,x builds up & increases ! hemoglob9 9 ! blood4 8,x increases ! numb] ( r$ blood corpuscles4 8,x regulates ! :ite cells4 8,x /imulates cell gr[?2 !re=e1 x is recon/ructive4 8,x is a p[]ful antiseptic4 8,x is useful 9 any septic condition40 ,9 view ( ! facts giv51 ! ,c\ncil aga9 refus$ recognition to ,bann]man's ,intrav5\s ,solution4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #b1 #aiae47 ,,iodalia,o ,ab/ract ( ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,o ,= ! unabridg$ report ( ! ,c\ncil's action on ,iodalia1 see ,reports ,c\ncil ,ph>m4 & ,*em41 #aiad1 p4 #fi4 ,iodalia is sold by ,geo4 ,j4 ,wallau1 ,inc41 ) ! claim t because ( ! peculi> comb9ation 9 :i* x conta9s iod9 x is a valuable & effici5t sub/itute = iodids4 ,! prep>ation 0 exam9$ 9 ! ,*emical ,laboratory ( ! ,am]ican ,m$ical ,association1 :i* report$ to ! ,c\ncil t1 contr>y to claim1 iod9 9 ! =m pres5t 9 ,iodalia w\ld1 :5 adm9i/]$1 act l an ord9>y iodid4 ,fur!r ! proportion ( iod9 pres5t 0 s small t to adm9i/] ! equival5t ( #bj gra9s ( potassium iodid x w\ld be necess>y to give ! cont5ts ( a "o-doll> bottle ( ,iodalia4 ,9 view ( ?is report x is evid5t t ! claim t ,iodalia is 8always well tol]at$0 & t x _c produce 8symptoms ( iodism0 is true only because ( ! small p]c5tage ( iod9 x conta9s4 ,! claims made 9 ! adv]tis+ matt]1 t ,iodalia is an effici5t iod9 m$ication 9 ! treatm5t ( syphilis1 t x is a suitable sub/itute = cod-liv] oil & t x may be us$ 9 anemia1 dysm5orrhea1 dyspepsia1 mal>ia & diseases ( ! he>t1 are entirely unw>rant$4 ,iodalia is exploit$ 9 a way to sugge/ its use to ! public = a ho/ ( diseases4 ,p>ticul>ly repreh5sible are ! recomm5dations conta9$ 9 a circul> :i* accompanies ! trade package t ,iodalia3 8444 (f]s ! same protection aga9/ grippe1 bron*itis1 pneumonia1 tub]culosis1 pleurisy & o!r infecti\s diseases t vacc9e does aga9/ small pox 4440 8,x is also ! be/ prev5tive aga9/ ! slight infections & ailm5ts to :i* debilitat$ & delicate *ildr5 are subject40 ,! ,c\ncil vot$ t ,iodalia be refus$ recognition4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,dec4 #ab1 #aiad47 ,,iodex ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,iodex is manufactur$ by ,m5ley & ,james1 ,ltd41 ,new ,york4 ,x is adv]tis$ z 8444 an embodim5t ( vaporiz$ iod9 9 an organic base1 r$uc$ & /&>diz$ at #e p] c5t4 by incorporation ) a ref9$ petroleum product40 ,! adv]tis+ conveys ! impression t ! effects ( free iod9 are to be obta9$ f ! prep>ation2 x is said to conta9 8#e p] c5t4 ,!rapeutically ,free ,iod9e10 & to d 8444 ev]y?+ ! doctor expects ( ,,free iod9 employ$ by inunction1 )\t "o physical or !rapeutic drawback40 ,! /atem5ts are also made t ! prep>ation 8nei!r /a9s1 irritates1 bli/]s or cracks ! sk910 & t 8?irty m9utes aft] inunction iod9 c be f\nd 9 ! ur9e40 ,! foll[+ report ( an exam9ation made by ! ,*emical ,laboratory ( ! ,am]ican ,m$ical ,association has be5 submitt$ to ! ,c\ncil3 8,iodex is d>k gre51 practically black4 ,! gre5 color is app>5t :5 ! o9tm5t is rubb$ on ! sk91 b disappe>s on cont9u$ rubb+4 ,?is non/a9+ prop]ty is expla9$ by ! results ( a te/ = free iod91 made on five specim5s1 f\r ( :i* yield$ only m9ute traces ( free iod91 :ile ! fif? yield$ none4 ,( c\rse1 ! /atem5ts t ,iodex is an #8,effective ,free ,iod9 ,application ,)\t ,drawbacks' & also a means ( #8,really ,effici5t ,ext]nal ,iod9e ,!rapy ,)\t ,/a9 or ,irritation' contradict ea* o!r4 ,free iod9 _c be pres5t 9 a suffici5t quantity to be !rapeutically effici5t 9 any application :i* does n /a9 or irritate ! sk94 8,! total iod9 cont5t ( ! five specim5s 0 f\nd to be #b4fc p] c5t4--a little ov] "o-half ( ! cont5t claim$4 8,absorption & excretion exp]im5ts 7 p]=m$ to te/ ! claim t #8?irty m9utes aft] inunction iod9 c be f\nd 9 ! ur9e4' ,9 sev]al subjects1 f #a to #b gm4 ( ,iodex 0 rubb$ on ! sk9 ( ! =e>ms1 & ! ur9e1 = p]iods v>y+ f sev5 to sev5ty-two h\rs1 0 collect$ & te/$ = iod94 ,9 all ( ! te/s ! results 7 negative40 ,iodex is adv]tis$ z b5eficial 9 muscul> sor5ess1 spra9s1 sciatica1 neuritis1 *ronic rheumatism1 enl>g$ gl&s1 or*itis1 epididymitis1 g\t1 burns & d]matomycoses4 ,x is also said to be 8,indicat$ 9 ,gl&ul> ,enl>gem5ts1 ,inflammatory ,conditions1 ,v>i\s ,jo9t ,diseases1 ,rheumatism1 ,sk9 ,diseases1 ,*ilbla9s1 etc41 etc40 ,to sum up3 #a4 ,z %[n 9 ! =ego+ laboratory report1 ! composition is incorrectly /at$1 = ! actual iod9 cont5t is only ab\t half ( t claim$4 #b4 ,x is n true t ! action ( ,iodex is ess5tially t ( free iod91 :i* is ! impression convey$ by ! adv]tis+4 #c4 ,! ass]tion made 9 ! adv]tis+1 t iod9 may be f\nd 9 ! ur9e %ortly aft] ,iodex has be5 rubb$ on ! sk91 has be5 exp]im5tally disprov$4 ,9 view ( ^! f9d+s1 ! ,c\ncil vot$ t ,iodex be refus$ recognition = conflict ) ,rules #a1 #d & #f4--7;,f ,! ,j\rnal ,a4 ,m4 ,a41 ,june #ai1 #aiae47 ,,iodia ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! foll[+ report on ,iodia 0 adopt$ by ! ,c\ncil & its publication au?oriz$4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,iodia is put on ! m>ket by ,battle & ,company1 "u ! claim t x conta9s potassium iodid 9 comb9ation ) iron phosphate & vegetable 8pr9ciples40 ,x is extravagantly recomm5d$ = use 9 _m & v>i$ conditions4 ,= in/ance1 x is 8an unexcell$ alt]o-recon/ructive10 8almo/ a specific0 9 eczema & rheumatism & 8a highly effici5t =m ( iod910 :i* w n produce iodism6 ,! !rapeutic effects ( iodids result f a *emical trans=mation by :i* molecul> iod9 is set free 9 ! tissues1 ?us produc+ a mild degree ( iodism4 ,x foll[s1 !n1 t a prep>ation :i* _c give rise to ! symptoms ( iodism _c be expect$ to produce ! !rapeutic effects ( ! iodids4 ,! claim t ,iodia is !rapeutically effici5t )\t produc+ iodism !re=e ju/ifies suspicion1 to put x mildly4 ,9 view ( ! exagg]at$ tone ( ! adv]tis+1 toge!r ) ! fact t a report f ! ,*emical ,laboratory ( ! ,am]ican ,m$ical ,association %[$ m>k$ discrepancies betwe5 ! =mula & ! composition ( ,iodia1 x seem$ desirable to inve/igate ?is product4 ,! report ( ! laboratory1 :i* is giv5 bel[1 %[s conflict ) ,rule #a 7secrecy ( composition7 & ) ,rule #b 7false claims ( /&>dization74 ,a discussion ( ! claims made = ,iodia foll[s ! report4 ,,laboratory ,,report ,! composition ( ,iodia is giv5 ?us3 8,=mula4--,iodia is a comb9ation ( active pr9ciples obta9$ f ! gre5 roots ( ,/ill+ia1 ,helonias1 ,saxifraga1 ,m5isp]mum & aromatics4 ,ea* fluid dra*m also conta9s two & "o-half gra9s ,iod4-,potas4 & "o & "o-half gra9s ,phos4-,iron40 ,we are told t3 8,its sev]al +r$i5ts are select$ ) scrupul\s c>e1 & ! mo/ exact+ me?ods are con/antly employ$ to insure absolute uni=mity & maximum !rapeutic pot5cy40 ,?is 8=mula0 is an absurdity3 ,fir/1 ! am\nts ( ! 8active pr9ciples0 ( ! plants nam$ are n giv52 second1 ^! 8pr9ciples10 ) ! possible exception ( m5isp]mum alkaloids1 h n be5 isolat$2 &1 ?ird1 f]ric phosphate & potassium iodid are incompatible6 ,incid5tally1 !re are no me?ods :]eby x is possible to secure 8absolute uni=mity0 ( a mixture su* z ,iodia is claim$ to be4 ,qualitative te/s demon/rat$ ! abs5ce ( iron & ! abs5ce ( all b traces ( phosphorus comp\nds 7#j4jae gm4 phosphorus p] #ajj c4c474 ,m9ute traces ( alkaloids1 possibly f m5isp]mum1 7 f\nd 7t am\nt be+ ab\t #j4jjd gm4 p] hundr$ c4c4 ( ! prep>ation74 ,!rapeutically ?is quantity is entirely negligible4 ,det]m9ations ( iodid demon/rat$ ! pres5ce ( only ab\t #fj p] c5t4 ( ! am\nt ( potassium iodid claim$4 ,! 8=mula0 = ,iodia is false & mislead+4#ee #ee ,x %\ld be not$ t ! discrepancies "h report$ betwe5 ! actual & ! claim$ composition ( ,iodia 7 po9t$ out m ?an ?irty ye>s ago by ,a4 ,b4 ,lyons 7,detroit ,lancet1 ,octob]1 #ahhb1 vi1 #aeg-h71 :o f\nd t ,iodia 0 defici5t 9 iodid cont5t & practically free f iron4 ,,dang]\s ,,recomm5dations ,"o ( ! ,iodia labels reads3 8,,indications4--,syphilitic1 scr(ul\s & cutane\s diseases1 dysm5orrhea1 m5orrhagia1 leucorrhea1 am5orrhea1 impair$ vitality1 habitual abortion & g5]al ut]9e debility40 ,su* recomm5dations are likely to lead to self-drugg+ 9 conditions t are n only dang]\s to ! individual b also a m5ace to ! community4 ,! prep>ation ?us conflicts ) ,rule #d ( ! ,c\ncil4 ,aft] admitt+ ! ne$ ( effici5t iodid m$ication 9 c]ta9 /ages ( syphilis & aft] exagg]at+ ! frequ5ce & sev]ity ( symptoms ( iodism1 an adv]tis+ circul> entitl$ 8,practical ,!rapeutics0 ass]ts3 8,iodia !n is ! prep>ation ( iodid ( potassium to be pref]r$ :5ev] x requires to be adm9i/]$ 9 l>ge doses or = prolong$ p]iods ( "t444 8,n only does ! association ( ! iodid ( potassium ) ! vegetable alt]atives (f] a measure ( protection aga9/ iodism b ! latt] ex]t depurative effects on _! own acc\nt 4440 ,x is g5]ally accept$ t 9 c]ta9 /ages ( syphilis ! only hope ( success lies 9 effici5t iod9 m$ication4 ,! exploit]s ( ,iodia /ate t a dose ( ! no/rum conta9s #b-a_/b gra9s ( potassium iodid2 actually x conta9s only #a-a_/b gra9s4 ,to urge physicians & ! public to dep5d on ?is product = effici5t iodid m$ication con/itutes an unw>rant$ !rapeutic exagg]ation 7,rule #f7 :i* approa*es crim9ality4 ,! reason ,iodia does n produce iodism is t1 9 ! doses recomm5d$1 ! iod9 action is extremely feeble4 ,lik5+ ! human body to a factory & discuss+ ! 8break d[ns0 :i* are likely to occur1 a circul> entitl$ 8,always ,tru/wor?y0 says3 8,:5 adm9i/]$ 9 prop] dosage1 ,iodia /imulates organic functions1 promotes ! elim9ation ( wa/e products1 & re-e/abli%es metabolic activity4 ,x increases ! solv5t prop]ties ( ! blood1 & arre/s abnormal tissue metamorphosis4 ,9 o!r words1 x l5ds mat]ial assi/ance to weak5$ cells & curbs ^? unduly active4 ,iodia1 obvi\sly1 has a wide range ( indications4 ,x has be5 mo/ g5]ally & successfully employ$1 h[ev]1 9 ,syphilitic1 ,scr(ul\s & ,cutane\s ,diseases1 ,rheumatic & ,g\ty ,ailm5ts1 ,dysm5orrhea1 ,m5orrhagia1 ,leucorrhea1 ,am5orrhea1 ,impair$ ,vitality1 ,habitual ,abortion & ,g5]al ,ut]9e ,debility1 & :]ev] a reliable alt]o-recon/ructive is requir$40 ,^! recomm5dations %[ t 9 addition to ! objections already giv51 ?is no/rum is an unsci5tific %ot-gun mixture4 ,?is br+s x 9 conflict ) ,rule #aj 7unsci5tific articles inimical to ! m$ical pr(ession & ! public74 ,x is recomm5d$ t ,iodia be refus$ recognition4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #ba1 #aiad47 ,,burnham',s ,,soluble ,,iod9e,p ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,p ,see also ,burnham's ,soluble ,iod9e1 p4 #bcc4 ,! ,c\ncil has au?oriz$ publication ( ! foll[+ report on ,burnham's ,soluble ,iod9e4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,burnham's ,soluble ,iod9e is (f]$ to ! m$ical pr(ession by ! ,burnham ,soluble ,iod9e ,company1 ,auburndale1 ,mass41 "u ! claim t by 8444 a new process hi!rto unkn[n to *emi/ry1 444 ,iod9e is conv]t$ into a soluble article--soluble 9 wat] & soluble 9 ga/ric secretions & 9 ! tissues40 ,beyond ?is no /atem5t z to ! qualitative or quantitative *emical id5tity ( ,burnham's ,soluble ,iod9e is furni%$2 ?is secrecy1 ( c\rse1 has giv5 ! prep>ation a c]ta9 my/]i\s pre/ige among un?9k+ physicians4 ,burnham's ,soluble ,iod9e 0 exam9$ 9 ! ,*emical ,laboratory ( ! ,am]ican ,m$ical ,association "s six ye>s ago & 0 f\nd to be an alcoholic solution ( free iod9 7approximately #c gm4 p] hundr$ c4c47 & comb9$ iod9 9 ! =m ( iodid 7equival5t to ab\t #b gm4 ( potassium iodid p] hundr$ c4c474 ,?us ! total iod9 cont5t 0 some:at less ?an half ( t ( ! (ficial ,t9cture ( ,iod9 7,tr4 ,iodi71 :i* conta9s #g gm4 ( free iod9 & #e gm4 ( potassium iodid to ea* #ajj c4c4 ,! (ficial t9cture1 dilut$ "o-half1 !re=e1 w\ld be ess5tially equival5t to ! ,burnham prep>ation1 bo? be+ miscible ) wat]4 ,! ,burnham ,soluble ,iod9e ,company object$ to ! conclusions drawn1 f ?is analysis1 b admitt$ ! correctness ( ! analysis itself4 ,any "o :o ga!r$ 8 fir/ k ( ! subject f ! ,burnham adv]tis+ might readily inf] t no soluble iod9 _h be5 kn[n prior to ,burnham's ,soluble ,iod9e4 ,?is1 ( c\rse1 is n ! case2 ! me?od ( produc+ a solution ( iod9 by ! use ( an iodid has long be5 kn[n4 ,! foll[+ /atem5t is n only obvi\sly untrue b also nons5sical3 8,9 all ! hi/ory ( iod9 m$ication1 cov]+ a p]iod ( laboratory rese>* ( _m ye>s duration1 e ef=t to produce a free iod91 prior to ! evolution ( ,burnham's ,soluble ,iod9e1 0 att5d$ by failure40 ,! company lays /ress on ! assum$ sup]iority ov] ! iodids ( a prep>ation conta9+ free iod94 ,?is assumption is bas$ on a fallacy4 ,^? :o reg>d free iod9 z sup]ior to comb9$ iod9 =get t free iod9 tak5 by ! m\? is conv]t$ 9 ! inte/9es1 by ! action ( ! alkal9e inte/9al secretions1 into an iodid ) a small am\nt ( iodate1 :ile adm9i/]$ intrav5\sly 7a proc$ure t1 :ile advocat$ by ! ,burnham conc]n1 is !rapeutically indef5sible71 x ent]s into comb9ation ) ! alkal9e salts & prote9s ( ! blood4 ,! free iod9 9 ,burnham's ,soluble ,iod9e mu/ act 9 ! sy/em z an iodid1 & ! :ole iod9 cont5t1 to furni% a correct e/imate ( ! value ( ! prep>ation1 %\ld be reckon$ z an iodid4 ,be>+ ?is 9 m9d1 !n1 x is evid5t t ! doses ( ,burnham's ,soluble ,iod9e recomm5d$ by ! manufactur]s are extremely small4 ,!y range f #bj m9ims 7equival5t to #a gra9 ( potassium iodid7 to #a_/b m9im 7equival5t to #a_/dj gra9 ( potassium iodid74 ,f #e to #bj m9ims 7equival5t to ab\t #a_/d to #a gra9 ( potassium iodid7 is ! dosage recomm5d$ = syphilis2 f 8#a to #c m9ims equival5t to f #a_/bj to #c_/bj gra9 ( potassium iodid ?ree to six times daily0 = typhoid & o!r inte/9al diseases4 ,no wond] ! exploit]s c say t ?is no/rum does n irritate ! inte/9es1 t x is 8non-irritat+ to ! weake/ /oma*0 & t !re is an 8entire abs5ce ( toxic action f maximum doses06 ,its alleg$ fre$om f ! irritat+ & unt[>d effects ( ord9>y iodids is due1 n to any inh]5t sup]iority ( ! prep>ation1 b to ! insignificant am\nt ( iodid pres5t4 ,! prep>ation is adv]tis$ = use 9 an extremely wide range ( diseases1 9 "s ( :i* iodid !rapy is recogniz$ z ( value1 :ile 9 o!rs x is g5]ally reg>d$ z ei!r wor?less or h>mful4 ,giv5 orally or intrav5\sly 7! recklessness ( ! latt] me?od %\ld aga9 be emphasiz$7 ,burnham's ,soluble ,iod9e is claim$ to be (3 8444 great utility z an int]nal antiseptic 9 tub]cul> affections 4440 ,s9ce1 z previ\sly expla9$1 free iod91 :5 introduc$ into ! body1 ent]s into *emical comb9ation be=e x has a *ance to p]meate ! tissues1 & s9ce ! alkali iodids possess v slight 79 fact1 = ?is purpose1 negligible7 antiseptic p[]s1 x is evid5t t ?is claim is unf\nd$4 ,s1 = ! same reason1 is ! claim t 8z an inte/9al antiseptic10 ,burnham's ,soluble ,iod9e is3 8444 effici5t 9 ,typhoid ,fev]1 ,ent]itis & o!r inte/9al diseases40 ,x is recomm5d$ 9 exoph?almic goit]1 not)/&+ t ?is condition is g5]ally recogniz$ z contra9dicat+ ! adm9i/ration ( iodids1 :i* excite ! action ( ! ?yroid gl&1 & :i* !re=e mu/ be us$ ) great circumspection4 ,an especially indef5sible recomm5dation is t #a_/b m9im ( ,burnham's ,soluble ,iod9e 7equival5t to #a_/dj gra9 ( potassium iodid7 be adm9i/]$ e five m9utes 9 8membran\s cr\p0--diph!ria--until relief f dyspnea is obta9$4 ,b1 ( all ! extravagant claims made = ?is prep>ation1 p]haps ! foll[+ is ! mo/ repreh5sible3 8,9 ! treatm5t ( ,ph?isis1 9 its v>i\s =ms1 cl9ical evid5ce cle>ly indicates t ! use ( ,,soluble ,,iod9e af=ds ! mo/ pot5t me?od ( treatm5t available4 ,dose--#b m9ims1 increas+ to #e m9ims 9 f\r ounces wat] be=e meals40 ,remove ! my/]y & tell physicians t a dose ( #a_/aj or #a_/d ( a gra9 ( potassium iodid is 8! mo/ pot5t me?od ( treatm5t available0 9 tub]culosis & ! absurdity becomes self-evid5t4 ,nor is ?is ! wor/ feature ( ! advice "h (f]$4 ,iod91 by comb9+ ) ! fatty acids ( tub]cul\s tissues1 promotes _! autolysis & consequ5tly _! s(t5+ & break+ d[n4 ,! products ( ?is autolysis are c>ri$ by ! lymphatics to heal?y tissues & ?us may spread ! infection4 ,!re=e ! use ( iodids 9 tub]culosis1 ev5 9 small dosage1 %\ld n be und]tak5 lightly4 ,x is recomm5d$ t ,burnham's ,soluble ,iod9e1 a semi-secret prep>ation1 exploit$ by means ( extravagant & dang]\s !rapeutic claims1 be held ineligible = admission to ,new & ,non(ficial ,rem$ies1 & t ?is report be publi%$4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,may #ae1 #aiae47 ,,iodotone,q ,ab/ract ( ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,q ,= ! unabridg$ report ( ! ,c\ncil's action on ,iodotone1 see ,reports ,c\ncil ,ph>m4 & ,*em41 #aiad1 p4 #gb4 ,eim] & ,am5d1 ,new ,york1 :o m>ket ,iodotone1 /ate t x is a solution ( hydrog5 iodid 7hydriodic acid7 9 glyc]91 conta9+ #a gra9 ( iod9 to ea* fluid dram4 ,! unw>rant$ ass]tion is made t ,iodotone 8444 w produce ! con/itutional effect ( iod9e 9 a %ort] "t ?an o!r prep>ations 4440 ,?is _c be true1 = x is c]ta9 t1 because ( ! alkal9e reactions ( ! tissues1 iodids1 :e!r adm9i/]$ z hydrog5 iodid or z alkali iodids1 mu/ circulate 9 precisely ! same =m & !re=e ex]t ! same !rapeutic effects 9 precisely ! same way4 ,eim] & ,am5d fur!r ass]t t ! ord9>y iodids may to advantage be replac$ by ,iodotone4 ,! absurdity ( ?is claim is app>5t :5 x is consid]$ t x w be necess>y to adm9i/] ne>ly "o fluid\nce ( glyc]9 to obta9 an am\nt ( ,iodotone equival5t to a #aj-;gra9 dose ( potassium iodid4 ,! additional claim t ,iodotone w n di/urb ! /oma* or produce ! usual disagreeable symptoms ( iodism is evid5tly unw>rant$1 = x is g5]ally conc$$ t symptoms ( iodism c be avoid$ only at ! risk ( insuffici5t iod9 m$ication4 ,because ( ^! unw>rant$ & mislead+ claims & because ! "n ,iodotone w\ld t5d t[>d ! uncritical use ( ! prep>ation z a g5]al tonic1 ! ,c\ncil vot$ t ,iodotone be refus$ recognition4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,dec4 #ab1 #aiad47 ,,iosal9e ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,iosal9e is a rheumatism rem$y = ext]nal application4 ,9 view ( ! mislead+ & unw>rant$ claims :i* are made = x1 ! ,c\ncil vot$ t ,iosal9e be refus$ recognition & recomm5d$ publication ( ! ,committee's report :i* appe>s bel[4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,,committee',s ,,report ,! foll[+ sweep+ b r indef9ite claims are made = ,iosal9e4 8,iosal9e is a p5etrator & ov]comes ! objectionable es*>otic prop]ties ( ,iod9e2 x is readily absorb$ & may be us$ )\t discom=t or discoloration40 8,! /rong analgesic prop]ties ( ,iosal9e make x especially useful 9 controll+ pa9 9 cases ( ,neuralgia1 ,rheumatism1 ,g\t1 & ,ar?ritis ,de=mans40 ,z !re are few1 if any1 kn[n iod9 comp\nds :i* are 8readily absorb$0 ?r\gh ! sk9 & :i* w n at ! same "t produce discoloration or discom=t1 x 0 ?\ght wor? :ile to take up ! exam9ation ( ,iosal9e4 ,! results ( ?is exam9ation are report$ by ! ,*emical ,laboratory ( ! ,association z foll[s3 ,laboratory ,report3--,iosal9e is adv]tis$ by ! ,iosal9e ,company ( ,new ,york1 z a rem$y = ! treatm5t by ext]nal application1 ( rheumatism1 g\t1 neuralgia1 pneumonia & num]\s o!r diseases4 ,conc]n+ its composition ! foll[+ /atem5ts are made3 8,a transp>5t1 non-/a9+ gelat9oid ( comb9$ iod9e ) m5?ol & me?yl salicylate4 8,alcohol #jgj4 p] c5t4 8,*emical te/s demon/rate ! prep>ation to conta9 #e p] c5t4 ( iod9e40 ,! plac+ ( a ciph] be=e ! p]c5tage figure = alcohol1 ?\gh p]haps accid5tal & n meant to mislead1 might cause a ha/y or c>eless read] to und]/& #g p] c5t4 or 4#jg p] c5t41 in/ead ( #gj p] c5t41 z ! proportion ( alcohol pres5t4 ,! prep>ation exam9$ 0 a v pale yell[i%1 transluc5t solid hav+ a /rong odor ( me?yl salicylate & a fa9t] odor ( m5?ol4 ,a package sold = #b ounces conta9$ #ea4g gm4 ,qualitative te/s indicat$ ! pres5ce ( alcohol1 an iodid1 m5?ol1 me?yl salicylate1 potassium1 sodium1 comb9$ fatty acids & a trace ( glyc]94 ,?yroid extract 0 n f\nd4 ,quantitative exam9ation indicat$ ! foll[+ approximate composition = ,iosal9e3 ,alcohol 7by weight7 #dh4je p] c5t4 ,m5?ol #b4jg p] c5t4 ,me?yl salicylate #aj4be p] c5t4 ,potassium iodid 7#d4be p] c5t4 iod97 #e4ee p] c5t4 ,soap #ab4fh p] c5t4 ,glyc]9 a trace ,wat] & undet]m9$ matt] to make #ajj p] c5t4 ,iosal9e1 !re=e1 appe>s to be a solidifi$1 wat]y-alcoholic solution ( soap conta9+ potassium iodid1 m5?ol & me?yl salicylate4 ,physiologic te/s c>ri$ out by rubb+ ! prep>ation on ! sk9 & aft]w>d te/+ ! saliva & ! ur9e = an iodid indicat$ t none ( ! potassium iodid is absorb$4 ,s9ce ,iosal9e is claim$ to conta9 #gj p] c5t4 ( alcohol & #e p] c5t4 ( iod91 ! alcohol cont5t is b #fh4g p] c5t4 & ! iod9 cont5t b #he p] c5t4 ( ! am\nts claim$4 ,! phrase 8comb9$ iod90 is evid5tly meant to mislead1 & adds ! elem5t ( my/]y on :i* prep>ations ( ?is class rely s l>gely4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,m>* #ae1 #aiac47 ,,n\rry ,,w9e,r,s ,ab/ract ( ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,r ,= ! unabridg$ report ( ! ,c\ncil's action on ,n\rry ,w9e1 see ,reports ,c\ncil ,ph>m4 & ,*em41 #aiad1 p4 #gd4 ,s ,= reports & articles on o!r acetanilid mixtures1 see pp4 #i1 #bdd1 #bfh1 #cje4 ,n\rry ,w9e 7,e4 ,f\g]a & ,co41 ,new ,york7 is a propriet>y iod9 prep>ation said to conta9 #ab p] c5t4 ( alcohol & #a-a_/b gra9s ( iod9 9 comb9ation ) tann9 to ! fluid\nce4 ,exp]im5ts made 9 ! ,a4 ,m4 ,a4 ,*emical ,laboratory demon/rate t ! iod9 conta9$ 9 ,n\rry ,w9e is pres5t ei!r 9 ! =m ( iodid ions or 9 a =m v readily yield+ iodid ions & t !re=e its action w be t ( ord9>y iodid4 ,yet a circul> ass]ts3 8,! ,n\rry ,w9e is ! "o prep>ation 444 able to introduce into ! organism ! active metalloid lib]at$ little by little f ! organic comb9ation44440 ,:ile ,n\rry ,w9e conta9s b an insignificant proportion ( iod91 ! circul> claims t 8,n\rry ,w9e pres5ts a high dose ( iod940 ,fur!r1 ! label on ,n\rry ,w9e & ! circul> :i* is wrapp$ ) x sugge/s its use 9 a numb] ( diseases 9 :i* iod9 m$ication is consid]$ ( m9or importance4 ,^! recomm5dations1 bol/]$ up by te/imonials f twelve to tw5ty-five ye>s old1 are likely to lead ! public if n ! m$ical pr(ession to use ?is weak iodid w9e :]e effici5t treatm5t is call$ =4 ,! attempt is made to give a fur!r false value to ,n\rry ,w9e 9 ! m9ds ( ^? :o prize ev]y?+ t is =eign by ! sugge/ion t x comes f ,france :5 9 reality x is made 9 ,new ,york4 ,9 conclusion ! ,c\ncil held t1 ?\gh ! alcohol ( ! w9e is ! mo/ pot5t con/itu5t1 ! con/ant use 9 ! adv]tis+ matt] ( ! t]m 8,n\rry ,w9e10 unqualifi$ by ! adjective 8,iod9at$10 0 mis*iev\s z likely to lead to ! ?\ghtless use ( ! prep>ation 9 cases unsuitable = iod9 m$ication4 ,! ,c\ncil refus$ recognition to ,n\rry ,w9e4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,dec4 #ab1 #aiad47 ,,labord9e ,a ,report by ! ,c\ncil & ,"s ,p]t95t ,comm5ts ,add$ ,!reto ,! foll[+ report 0 submitt$ to ! ,c\ncil on ,ph>macy & ,*emi/ry by ! subcommittee :i* exam9$ ,labord9e3 ,to ! ,c\ncil on ,ph>macy & ,*emi/ry3--,y\r subcommittee pres5ts ! foll[+ report on ,labord9e1 sold by ! ,labord9e ,ph>macal ,co41 ,/4 ,l\is4 ,labord9e is adv]tis$ to physicians z hav+ ! foll[+ composition3 ,apium ,graveol5s 7true active pr9ciple7 8,process-,laborde0 #ce-c_/h ,gaul!ria ,fragrantissima 7true active pr9ciple7 8,process-,laborde0 #be-a_/h ,acete ,amide-,ph5yle #ae-a_/h ,qu99a #a-a_/h ,b5zoyl-,sulphyonic-,imide #bc-a_/d ,x is /at$ to be a 8vegetable antipyretic02 t 8x r$uces temp]ature )\t he>t depression10 & physicians are w>n$ to 8avoid acetanilid poison+ & dang] f o!r coal-t> antipyretics40 ,illu/ration ,:ile ! 8=mula0 & ! /atem5t j quot$ are suffici5t evid5ce ( ! fraudul5t "* ( ! product1 yet an ab/ract ( ! reports ( ! *emi/s :o analyz$ x is giv5 fur!r to demon/rate its "*4 ,tak+ ! av]age ( ! reports ( analyses1 labord9e conta9s3 ,acetanilid #cg4i ,free salicylic acid #f4i ,qu99 pres5t ,corn />* pres5t ,milk sug> #cd4g ,?is report ( analysis only makes app>5t t ,labord9e is n :at x is claim$ to be4 ,:ile x is claim$ to conta9 #bc-a_/d p] c5t4 sac*>91 ?is sub/ance 0 n pres5t1 or m]e traces only4 ,:ile1 9 a disguis$ way1 x is /at$ to conta9 #ae-a_/h p] c5t4 acetanilid1 x conta9$ ne>ly #dj p] c5t4 ,x is recomm5d$ t ,labord9e be n approv$ & t ?is report be publi%$4 ,! recomm5dation ( ! subcommittee 0 adopt$ by ! ,c\ncil1 & 9 accordance !re) ! above report is publi%$4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,,comm5ts ,a concrete illu/ration ( "s g5]al pr9ciples previ\sly laid d[n is furni%$ by a no/rum too unimportant to be ( any value1 save to 8po9t a moral & adorn a tale40 ,ab\t ?irte5 ye>s ago ,labord9e 0 adv]tis$ "u ! "n ( ,analg9e-,labord9e1 8,a purely vegetable product10 8a comb9ation ( ! active pr9ciples ( ,camellia ,!a1 ,apium ,graveol5s1 sac*>9 & c>bohydrates10 8,sup]ior to ,antipyr9e1 ,ph5acet9e1 ,antifebr9e1 ,acetanilid0--note ! use ( two names = ! same ?+--8or any ( _! imitations10 & 8unexcell$ by any coal-t> product or _! comp\nds40 ,9 #ahid ! "n 0 *ang$ to ,labord9e1 9 ord]1 z its own] /at$1 to prev5t its be+ mi/ak5 = a coal-t> product ( simil> "n4 ,:at its composition 0 at ?is "t we d n "k1 s9ce !re is no gu>antee ( ! p]man5ce nor /ability ( no/rum =mulas except 8! honor & reputation ( ! manufactur]s10 :i*1 z inve/igation has %[n1 is n always unimpea*able4 ,!re has be5 no?+ to prev5t alt]ation ( ! =mula1 if ! proprietors desir$1 ) e *ange 9 ! moon4 ,b ! "n & ! g5]al tone ( ! adv]tis+ has be5 ! same4 ,! claim ( sup]iority ov] coal-t> products has be5 con/antly made4 ,z to ! pres5t conditions1 a circul> enclos$ ) a sample ( ,labord9e1 rec5tly s5t f ! ,/4 ,l\is (fice1 conta9s ! =mula giv5 above 9 ! report ( ! ,c\ncil4 ,9 ! same circul> are also f\nd ^! illum9at+ /atem5ts3 8,! m$ical pr(ession has long appreciat$ ! dang]s involv$ 9 ! adm9i/ration ( v>i\s m9]al rem$ies n[ s commonly employ$1 & ! value ( a safe1 effective & reliable vegetable antipyretic is univ]sally recogniz$4 ,su* a rem$y is ,labord9e4 ,x is purely vegetable 9 its composition & produces none ( ! evil aft]-effects ( ! coal-t> d]ivatives4444 ,labord9e 444 is a purely vegetable c>diac /imulant4444 ,!re is no?+ my/]i\s ab\t ,labord9e or its con/itu5ts4444 ,! #8,process-,laborde' gives ! true active pr9ciples ( ! ,cel]y & ,indian ,w9t]gre51 some?+ h]et(ore difficult to obta94 ,to ?is is add$ ! fact t absolutely *emically pure ,acet-,amide-,ph5yle is us$4 ,! latt] is ! mo/ valuable &1 9 fact1 ! only vegetable antipyretic kn[n40 ,! above report ( ! ,c\ncil %[s ! foll[+ facts3 #a4 ,apium ,graveol5s 7true active pr9ciple71 8,process-,laborde0 is probably p[d]$ cel]y se$4 ,"o *emi/ says3 8,! p[d] has ! *>act]i/ic odor ( cel]y1 :ile a microscopic exam9ation %[s ! pres5ce ( a sub/ance hav+ ! *>act]i/ic /ructure ( se$s 9 g5]al40 ,if cel]y se$ has any 8active pr9ciple0 x has nev] be5 isolat$4 ,z to its !rapeutic value1 no?+ :atev] is kn[n4 ,x is1 we und]/&1 highly b5eficial 9 ! case ( s++ can>ies1 b au?orities 9 sci5tific !rapeutics h nev] discov]$ t x possess$ any rem>kable m$ic9al qualities4 #b4 ,gaul!ria ,fragrantissima 7true active pr9ciple71 8,process-,laborde10 is probably ord9>y ev]yday salicylic acid4 ,"o analysis %[$ salicylic acid to be pres5t to ! am\nt ( ab\t #g p] c5t4 ,! "q ( :e!r or n salicylic acid c\ld 9 any way be consid]$ ! 8true active pr9ciple0 ( ,gaul!ria ,fragrantissima1 0 submitt$ to ,pr(4 ,john ,uri ,lloyd ( ,c9c9nati1 ! em95t au?ority on ! *emi/ry ( ! proximate pr9ciples ( plants1 :o replies3 8,! adv]tisem5t is evid5tly s word$ t1 al?\gh ! "n ( ! ,indian plant ,gaul!ria ,fragrantissima is employ$1 its true & active pr9ciple be+ w9t]gre5 oil1 ! concoctor c my/ify 8 patrons & at ! same "t use ! well-kn[n w9t]gre5 oil1 made 9 ,am]ica1 :i* 9 my op9ion1 s f> z any *emical te/ might be conc]n$1 c\ld n be di/+ui%$ f ! me?yl salicylic acid 7w9t]gre5 oil7 d]iv$ f ! ,indian plant4 ,conc]n+ :e!r salicylic acid is a proximate con/itu5t ( ,gaul!ria ,fragrantissima1 9 my op9ion1 x w\ld be a misnom] to make su* an ann\ncem5t4 ,salicylic acid1 p] se1 does n exi/1 9 my op9ion1 9 ! plants m5tion$1 be+ made by *emi/ry40 #c4 ,! ?ird & mo/ important +r$i5t 9 ?is 8purely vegetable antipyretic0 is braz5ly ann\nc$ z 8,acet-,amide-,ph5yle10 b x is only necess>y to say t ?is impos+ designation is an attempt to 8,fr5*ify0 a sci5tific "n = acetanilid4 ,analysis %[s t ?is coal-t> product is pres5t to ! am\nt ( #cg4i p] c5t41 or #a4hi gra9s 9 a #e-;gra9 tablet4#ef ,9 o!r words1 ?is impos+ ,labord9e1 made by a my/]i\s & else:]e unhe>d ( 8,process-,laborde10 is simply "o m ( ! _m acetanilid p[d]s t h be5 foi/$ on our pr(ession & t h fill$ our j\rnals = ye>s pa/4 ,! only ?+ 9 x t is ( practical !rapeutic value is #b gra9s ( acetanilid to a #e-;gra9 tablet4 ,! /atem5t t ,labord9e is a purely vegetable prep>ation is probably int5d$ by ! proprietors z a good joke on ! m$ical pr(ession4 ,acetanilid is n usually reg>d$ z a vegetable product1 at lea/ x is n ord9>ily f\nd 9 m>ket g>d5s4 ,! only vegetable s\rce f :i* acetanilid c be obta9$ is ! beautiful fl[]+ coal-t> bu%1 f :i* s _m o!r no/rum v5dors obta9 _! 8p]fectly h>mless1 purely vegetable antipyretics10 all compos$ ( acetanilid & some?+ to hide x4 ,if ! /atem5ts made by "o ( ! company's employees & quot$ bel[ are true1 ,labord9e is n 8manufactur$ & made *emically pure 9 ! laboratories ( ! ,labord9e ,ph>macal ,company10 = ?is company has no laboratory1 & its product is manufactur$ = x4 #ef ,s9ce ?is article 0 prep>$ we f9d t ! national ,food & ,drugs ,act has =c$ ! proprietors ( ,labord9e to put on ! label ! am\nt ( acetanilid x conta9s1 viz41 #dj p] c5t41 or #b gra9s 9 a #e gra9 tablet4 #d4 ,our read]s w be int]e/$ to "k t ! important +r$i5t ent]$ "u ! impos+ "n ( ,b5zoyl-,sulphyonic-,imide is simply a highly sci5tific "n = sac*>94 ,ev5 on ?is po9t1 h[ev]1 ! =mula is mislead+1 s9ce x claims #bc-a_/d p] c5t4 ( ?is sub/ance1 :]eas ! analysis %[s t ! pres5ce ( sac*>9 c\ld n be prov$4 ,if x is pres5t at all x is 9 quantities mu* less ?an /at$1 & s small z to be difficult ( recognition4 ,in/ead x appe>s t ! product conta9s common />* & ab\t #ce p] c5t4 ( milk sug>4 ,,! ,,company ,,itself ,"o ( ! humiliat+ phases ( ! propriet>y m$ic9e bus9ess is t1 9 _m in/ances1 ^! prep>ations are foi/$ on our pr(ession by m5 :o "k no?+ ( m$ic9e1 ph>macy or *emi/ry1 yet :o n only presume to concoct our m$ic9es = u1 b also assume to in/ruct u h[ to use !m4 ,g\ld's ,comm]cial ,regi/] = #aijg gives ! (fic]s ( ! ,labord9e ,ph>macal ,company z ,h4 ,m4 ,c\drey1 presid5t2 ,m4 ,crawley1 vice-presid5t1 & ,d4 ,e4 ,gamble1 ,jr41 secret>y & treasur]4 ,! place ( bus9ess is giv5 z #dbj ,m>ket /reet1 ,/4 ,l\is4 ,we are in=m$ t ,h>ry ,m4 ,c\drey is an insurance ag5t & ! pres5t memb] ( ,congress f ! ,twelf? ,miss\ri ,di/rict2 t ,m>k ,crawley is a cl]k 9 ! insurance (fice ( ,h4 ,m4 ,c\drey2 & t ,mr4 ,gamble is ca%i] 9 ! same (fice4 ,a rec5t visit ( a repres5tative ( ,! ,j\rnal to #dbj ,m>ket /reet1 ,/4 ,l\is1 %[$ t ! (fice ( ! ,labord9e ,ph>macal ,company is 9 ,room #ab on ! ?ird floor ( an old dilapidat$ build+4 ,!re 0 no sign on ! door ( ! (fice1 b on ! wall next to an old elevator 0 a v small sign :i* read 8,labord9e ,*emical ,company1 ,room #ab40 ,! (fice at ! "t ( ! visit 0 app>5tly 9 *>ge ( a "y woman ab\t #bj ye>s old4 ,c>eful scrut9y ( ! furniture & fixtures %[$ t ! room conta9$ an old oak roll-top desk 9 "o corn] & a kit*5 table1 on :i* 7 pil$ ab\t half a doz5 packages ( ,labord9e4 ,! floor ( ! room 0 b>e & v dirty4 ,9 an adjo9+ room1 ! door ( :i* 0 op51 0 pil$ a lot ( brok5 furniture4 ,no laboratories nor *emical app>atus 7 visible4 ,! "y woman 9 *>ge /at$ t ,labord9e 0 made by ! ,mall9ckrodt ,*emical ,works1 at ,no4 #cfjj ,nor? ,second ,/reet1 ,/4 ,l\is4 ,?is is a fair sample ( no/rums & ( ! me?ods ( exploit+ !m4 ,! bitt]ly humiliat+ fact ab\t ! :ole bus9ess is t a prep>ation1 adv]tis$ "u su* palpably mislead+ claims1 c\ld actually be adv]tis$ 9 m$ical j\rnals1 ev5 9 j\rnals ( a suppos$ly high sci5tific /&>d1 & c\ld be b\ght & prescrib$ = ye>s by suppos$ly intellig5t & consci5ti\s physicians4 ,x is n suppos$ t e physician %\ld be en\gh ( a *emi/ to detect ! ridicul\s discrepancies betwe5 ! publi%$ =mula & ! !rapeutic claims made = su* a mixture4 ,b t memb]s ( a suppos$ly le>n$ pr(ession %\ld fail to h en\gh int]e/ 9 ! prep>ations !y prescribe = _! confid+ pati5ts to f9d out t acetanilid is be+ mask$ "u an obsolete & little us$ "n1 t "u an impos+ polysyllabic designation is hidd5 sac*>91 t ! s-call$ 8active pr9ciple ,process-,laborde0 7:atev] t may be71 is equival5t only to "o-?ird gra9 ( salicylic acid 9 a #e-;gra9 tablet1 & t ! adv]tis+ matt] s5t out = ye>s by ?is company conta9$ absolute falsehoods reg>d+ ! composition & !rapeutic b5efits ( its prep>ation1 is c]ta9ly j cause = %ame & humiliation4 ,if a physician1 kn[+ ! composition ( ,labord9e1 wi%es to prescribe x & prescribes x intellig5tly1 he has a p]fect "r to d s4 ,if he wi%es 8 pati5t to h #b gra9s ( acetanilid1 #a_/bj ( a gra9 ( qu991 & #a_/c ( a gra9 ( salicylic acid1 & consid]s a mixture ( gr\nd cel]y se$1 />* & milk sug> z a prop] vehicle = ?is m$ication1 no "o w "q 8 "r to adm9i/] x4 ,no physician1 h[ev]1 has any "r1 ei!r moral or pr(essional1 to prescribe a prep>ation1 conc]n+ ! +r$i5ts ( :i* he kn[s absolutely no?+4 ,is x possible t su* c>elessness may be "o ( ! causes ( wan+ public confid5ce 9 our pr(ession8 ,we leave x to our read]s to det]m9e :e!r su* a moral c be drawn f ?is typical no/rum /ory4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,m>* #cj1 #aijg47 ,,lactobacill9e ,,omitt$ ,,f ,n4 ,n4 ,r4 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,franco-,am]ican ,f]m5t ,company has advis$ ! ,c\ncil on ,ph>macy & ,*emi/ry t1 9 adv]tis+ its products1 x w no long] con=m to ! rules ( ! ,c\ncil4 ,?is is evid5t4 ,! ,franco-,am]ican ,f]m5t ,company has di/ribut$ circul>s 9 :i* ! public is in=m$ t auto-intoxication is ! cause ( innum]able ills rang+ all ! way f art]ioscl]osis1 rheumatism & g\t to *ronic heada*e1 odor\s p]spiration1 n]v\s disord]s & melan*olia2 t ! ,bulg>ian bacillus 8is a wond]ful corrective or rem$y0 = all ^! conditions1 & t ! ,lactobacill9e products are ! only prep>ations ( ,bulg>ian bacillus 8to be _h 9 ,am]ica :i* be> 8 ,pr(essor ,met*nik(f's p]sonal endorsem5t0--by inf]5ce1 ! only reliable products4 ,9 view ( ! action ( ! ,franco-,am]ican ,f]m5t ,company1 & ( ! t5d5cy ( _! adv]tis+ to cause ! public to exagg]ate slight ailm5ts into al>m+ conditions1 ! ,c\ncil has vot$ t ! sev]al ,lactobacill9e products ( ?is conc]n be delet$ f ,new & ,non(ficial ,rem$ies4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,april #ag1 #aiae47 ,,reexam9ation ,,( ,,lactopept9e,t ,report to ! ,c\ncil on ,ph>macy & ,*emi/ry ,t ,see also ,liquid ,comb9ations ,conta9+ ,peps9 & ,pancreat91 p4 #aeg4 ,a repr9t ( articles be>+ on ?is subject1 issu$ "u ! title ,dige/ive ,impossibilities1 w be s5t on receipt ( a #b-;c5t /amp4 ,9 #aijg ! ,c\ncil on ,ph>macy & ,*emi/ry publi%$ a report on ,lactopept9e4 ,at t "t x 0 %[n t ,lactopept9e did n h ! composition claim$ = x4 ,! same claims z to composition are /ill be+ made = ! product4 ,9 view ( ?is fact1 a second exam9ation ( ,lactopept9e has be5 made & ! result report$ to ! committee on *emi/ry4 ,! report confirms ! ,c\ncil's f9d+s ( six ye>s ago4 ,aft] adoption by ! committee1 x 0 adopt$ by ! ,c\ncil & its publication au?oriz$4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,,second ,,exam9ation ,,( ,,lactopept9e ,two specim5s ( ,lactopept9e 9 orig9al unbrok5 packages 7 rec5tly exam9$4 ,"o ( ^! 0 an ,am]ican prep>ation said to be produc$ by ! ,new ,york ,ph>maceutical ,association at ,yonk]s & ! o!r an ,engli% prep>ation f ,john ,morgan ,ri*>ds & ,sons1 ,london4 ,:5 ,lactopept9e 0 fir/ exam9$ by ! ,c\ncil ab\t six ye>s ago1 x 0 f\nd to be little m ?an weak sac*>at$ peps91 & did n conta9 ! o!r f]m5ts :i* 7 claim$ by ! manufactur]s to be pres5t4 ,a /atem5t conc]n+ ?is 0 publi%$ 9 ! ,c\ncil ,reports = #aije-aijh1 p4 #dc4 ,because ( claims rec5tly made by ! exploit]s t ?is prep>ation conta9s n only peps9 b also pancreat91 dia/ase1 lactic acid & hydro*loric acid1 & t ! failure to recognize ^! mu/ be due to ! lack ( ability ( ! *emi/s mak+ ! exam9ation1 x seem$ wor? :ile to und]take a new s]ies ( te/s on samples f two s\rces m5tion$1 ! products on ! ,briti% & ,am]ican m>kets4 ,! label on ! ,briti% sample gives ! foll[+ z ! composition3 ,sug> ( ,milk #dj ounces ,peps9 #h ounces ,pancreat9e #f ounces ,ptyal9 or ,dia/ase #d dra*ms ,lactic ,acid #e fl4 dra*ms ,hydro*loric ,acid #e fl4 dra*ms ,! label on ! ,am]ican sample gives no quantities b /ates t x 8repres5ts a comb9ation ( ! pr9cipal dige/ive & enzymog5ic ag5ts1 ,peps91 ,pancreat91 ,dia/ase1 ,lactic & ,hydro*loric ,acids1 9 ! prop] proportion to insure be/ results40 ,we h exam9$ bo? prep>ations = />*-dige/+ p[] accord+ to ! me?ods employ$ 9 our previ\s exam9ations ( su* f]m5ts & already report$4 ,dia/ase & ! amylops9 ( pancreat9 seem to be completely abs5t1 or1 if pres5t at all1 9 su* m9ute traces t dige/ion ( />* is n %[n aft] "o h\r :5 quantities runn+ f #fj mg4 up to #aej mg4 7 all[$ to act on #ejj mg4 ( />* made up into pa/e4 ,^! te/s 7 repeat$1 always ) ! same results1 & 7 controll$ by dige/ions ( ! same />* ) o!r dia/ase prep>ations ( kn[n value4 ,tryptic activity appe>s likewise to be abs5t1 z 9 weak alkal9e solution aft] fifte5 h\rs' dige/ion no effect on coagulat$ egg album9 or fibr9 0 obs]v$ :5 #ajj mg4 ( ea* prep>ation 0 us$ ) #a gm4 ( ! prote9 mat]ial4 ,z 0 f\nd 9 ! previ\s inve/igation ! two products h "s peptic activity1 b ?is activity is comp>atively weak1 z ab\t #bjj mg4 ( ea* prep>ation are requir$ to dige/ #aj gm4 ( coagulat$ egg album9 ) #j4b p] c5t4 hydro*loric acid 9 ?ree h\rs at #dj ,c4 7#ajd ,f471 & #ajj mg4 portions 7 unable to completely dige/ #aj gm4 portions ( egg album9 ) acid ( ! same /r5g? 9 f\r h\rs at #ej ,c4 7#abb ,f474 ,hydro*loric acid is abs5t1 z might be expect$ f ! "* ( ! prep>ation1 & ! am\nt ( comb9$ *lorid is small2 b qualitative te/s 7 obta9$ = organic acid resembl+ 9 behavior lactic acid1 :i* is probably pres5t 9 comb9$ =m4 ,x mu/ be reaffirm$ !n t 9 dige/ive activity bo? ! ,lactopept9e pur*as$ 9 ! ,unit$ ,/ates & t b\ght 9 ,engl& are ess5tially weak sac*>at$ peps9s4 ,editorial ,note4--,! report ( #aijg demon/rat$ t ,lactopept9e 0 at t "t a weak sac*>at$ peps94 ,! pres5t report %[s t ,lactopept9e1 z x is sold bo? 9 ! ,unit$ ,/ates & ,great ,brita91 is /ill ! same weak peps9 prep>ation4 ,by ! false /atem5ts :i* appe> on ! ,lactopept9e labels ! exploit]s lay !mselves liable to prosecution "u ! ,food & ,drugs ,act--j z !y h laid !mselves liable = ! pa/ six ye>s4 ,! cont9u$ exploitation ( ?is prep>ation w>rants a re/atem5t ( facts t h be5 giv5 _m times be=e3 #a4 ,a prep>ation hav+ ! composition claim$ = ,lactopept9e--a p[d] conta9+ peps91 pancreat91 dia/ase1 lactic acid & hydro*loric acid--_c be produc$ comm]cially4 #b4 ,ev5 if su* a comb9ation 7 available1 ! acidity ( ! mixture itself & ( ! ga/ric juice w\ld 9 all probability de/roy ! pancreat9 be=e x c\ld rea* ! inte/9al tract4 #c4 ,ev5 if e con/itu5t c\ld ex]t its prop] function at ! "r "t1 ! adm9i/ration ( su* a %otgun mixture w\ld be unsci5tific & uncall$ =4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,aug4 #b1 #aiac47 ,,meat ,,& ,,beef ,,juices,u ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,u ,see also foll[+ report on ,val5t9e's ,meat ,juice & article on ,meat ,extracts & ,meat ,juices1 p4 #dgj4 ,! foll[+ 0 submitt$ to ! ,c\ncil by a subcommittee3 ,to ! ,c\ncil3--,:ile meat extracts conta9 only traces ( coagulable proteids & h little food value1 meat juices are prep>$ by a process :i* ensures ! pres5ce 9 ! f9i%$ product ( consid]able quantities ( coagulable proteids & !y !re=e h consid]able value z foods4 ,_m prep>ations :i* are sold z beef juices or meat juices h no "r to ^! designations4 ,s9ce ! public & physicians are likely to be misl$ by ! names giv5 to ^! products & by ! false claims :i* are made = !m z foods & dep5d on !m 9 ! n\ri%m5t ( ! sick1 x is important t _! composition & _! value z foods %\ld be kn[n4 ,9 ! foll[+ report is pres5t$ ! results ( an exam9ation ( "s ( ! comm]cial products f\nd on ! ,am]ican m>ket4 ,! report %[s t ,wye?'s ,beef ,juice 7,john ,wye? ,bro41 ,philadelphia71 ,bov99e 7,! ,bov99e ,co41 ,new ,york71 ,c>n9e 7,c>n9e ,co41 ,f\g]a ,co41 ,new ,york71 & ,val5t9e's ,meat ,juice 7,m4 ,j4 ,val5t9e1 ,ri*mond1 ,va47 are sold "u names :i* are incorrect1 t _! composition is n correctly /at$ by ! manufactur]s & t false & mislead+ /atem5ts are made 9 reg>d to _! value z food4 ,x is recomm5d$ t ! products nam$ be refus$ recognition = conflict ) ,rules #a1 #f & #h4 ,s9ce ^! prep>ations are typical ( _m o!rs on ! m>ket1 & z _! use is a m5ace to ! public heal? x is recomm5d$ t ! report be publi%$4 ,?is report 0 adopt$ by ! ,c\ncil4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,beef or meat juices are cle>ly to be di/+ui%$ f beef or meat extracts4 ,! ^w 8juice0 applies solely to ! fluid portion rema9+ 9 fre% meat aft] prop] cool+ & /or+ & may be obta9$ by pressure or diffusion ) or )\t a l[ degree ( heat4 ,"u heavy pressure fre%ly *opp$ meat w yield f #be p] c5t4 to #dj p] c5t4 ( a ?ick r$di% juice & if ! meat is previ\sly froz5 or heat$ to #fj ,c41 z mu* z #ej p] c5t4 may be obta9$4 ,?is gives "s idea z to ! probable co/ ( prep>+ beef juice at home4 ,! *ief *>act]i/ics ( meat juice are ! pres5ce ( a consid]able proportion ( coagulable prote9 & a l[ cont5t ( meat bases4 ,t above repres5ts ! nature ( ^! commodities z usually und]/ood by ! m$ical pr(ession1 is cle>ly %[n by ?is quotation3#eg #eg ,brunton1 ,sir ,laud]3 8,disord]s ( ,assimilation1 ,dige/ion1 etc410 p4 #ahc4 8,"o or two teaspoonfuls ( ?is 7meat juice7 are add$ to a teacupful ( cold or w>m wat]1 :i*1 h[ev]1 mu/ n be boil+1 or o!rwise ! album9 w\ld be coagulat$1 b x may1 h[ev]1 be suffici5tly w>m to dr9k com=tably40 ,beef juice is consid]$ by "s physicians ( mu* dietetic s]vice & believ$ to repres5t liquid food 9 conc5trat$ =m4 ,w4 ,o4 ,atwat]1#eh relative to ?is product says3 8,beef juice obta9$ f ! be/ /eak :i* has be5 m]ely w>m$ ?r\gh ov] ! coals & !n entirely depriv$ ( soluble sub/ance by a screw press1 is und\bt$ly ! mo/ conc5trat$ ( ! liquid foods40 #eh ,bull4 ,no4 #ba1 ,u4 ,s4 ,dept4 ,agricult41 ,(fice ( ,exp]im5t ,/ations4 ,! latt] au?ority gives a numb] ( analyses ( beef juices prep>$ "u kn[n conditions4 ,,def9ition ,,( ,,meat ,,juice ,meat juice is def9$ by ! /&>ds committee ( ! ,association ( ,(ficial ,agricultural ,*emi/s z ! fluid portion ( muscle fib] obta9$ by pressure or o!rwise1 & may be conc5trat$ by evaporation at a temp]ature bel[ ! coagulat+ po9t ( ! soluble prote94 ,! solids conta9 n m ?an #ae p] c5t4 ( a%1 n m ?an #b4e p] c5t4 ( sodium *lorid 7calculat$ f ! total *lor9 pres5t71 n m ?an #d nor less ?an #b p] c5t4 ( phosphoric acid 7,p#b,o#e71 & n less ?an #ab p] c5t4 ( nitrog54 ,! nitrog5\s bodies conta9 n less ?an #ce p] c5t4 ( coagulable prote9s & n m ?an #dj p] c5t4 ( meat bases4 ,meat juices ( comm]ce are suppos$ to be made by subject+ prop]ly prep>$ meat to heavy pressure ) subsequ5t conc5tration ( ! juice 9 vacuo at a l[ temp]ature4 ,! latt] is necess>y because if ! temp]ature is rais$ to any mat]ial ext5t ! valuable coagulable1 soluble prote9s ref]r$ to above are precipitat$ & lo/4 ,9 ord] to e/abli% a basis ( comp>ison relative to ! composition ( natural raw beef juice a numb] ( samples 7 prep>$ "u kn[n conditions & submitt$ to analysis4 ,! results conta9$ 9 ! subjo9$ table cle>ly %[ t meat juices made "u kn[n conditions v>y accord+ to ! mode ( prep>ation1 b x is evid5t t practically "o-half ( ! nitrog5 is pres5t z coagulable prote94 ,,food ,,values ,9 ord] to arrive at ! food value ( any commodity x is necess>y to consid] its *emical composition1 available pot5tial en]gy1 absorbability1 etc4 ,on ref]r+ to ! analytical table x w be f\nd t ! am\nt ( inorganic mat]ial 9 meat juices ,nos4 #g & #aj is unduly high4 ,x appe>s t sodium *lorid1 p] se1 has be5 add$ to bo? ,bov99e & ,wye?'s ,beef ,juice probably z a pres]vative 9 ! latt] & = condim5tal purposes 9 ! =m]4 ,! relative & absolute proportions ( phosphatic mat]ial 9 bo? products is excessive4 ,! o!r con/itu5ts pres5t 9 ! a% are ^? usually f\nd 9 meat products4 ,! am\nt ( sug> & glyc]9 9 ,c>n9e is int]e/+4 ,^! ag5ts may be add$ = pres]v+ purposes1 b ! result+ product1 on acc\nt ( its syrupy appe>ance1 leads to ! belief & is s repres5t$1 t x is a conc5trat$ food4 ,glyc]9 is also pres5t 9 ,bov99e & ,val5t9e's meat juice4 ,bov99e 9 addition conta9s ab\t #h p] c5t4 alcohol4 ,! total nitrog5 cont5t ( ! trade products except+ ,c>n9e1 is great] ?an ! am\nt ( nitrog5 pres5t 9 meat juices prop]1 b ! relative am\nt ( nitrog5 pres5t z coagulable prote9--! valuable "p ( meat juice--is mu* great] 9 ! latt]4 ,9 fact1 ! am\nt ( coagulable prote9 pres5t 9 ,val5t9e's ,meat ,juice may be consid]$ nil1 :i* indicates t an unduly high temp]ature is us$ 9 its prep>ation4 ,9 ?is connection x %\ld also be not$ t ev5 a mod]ate elevation ( temp]ature influ5ces ! *emical composition ( meat juices4 ,= example1 ! coagulable matt] pres5t 9 ,nos4 #c1 #d & #e1 is approximately "o-half t pres5t 9 ,nos4 #a & #b1 :i* appe>s to indicate t ! be/ product c be made )\t ! use ( any heat :atev]4 ,sev]al ( ! trade products1 namely ,nos4 #g1 #h & #i1 conta9 ab\t z mu* coagulable mat]ial z meat juice made by heat+ beef to #fj ,c4 ,accord+ to ! =mula appe>+ 9 a circul> ( ! ,bov99e ,company1 a "p ( ! coagulable matt] is pres5t 9 ! =m ( egg album91 b ! company claims egg album9 is n us$ at pres5t4 ,9 ! case ( ,c>n9e1 ! coagulable matt] appe>s to be introduc$ by ! use ( blood itself4 ,! exact nature ( ! coagulable prote9 matt] 9 ,wye?'s ,beef ,juice has n be5 asc]ta9$4 ,x is well kn[n to manufactur]s & physiologic *emi/s t x is practically impossible to manufacture a g5u9e meat juice possess+ a reasonable am\nt ( coagulable prote9s1 :i* is /able )\t a pres]vative4 ,meat juices1 9 addition to ! coagulable prote9 mat]ial1 conta9 o!r prote9 bodies su* z albumoses & peptones4 ,^! bodies are l>gely =m$ f ! orig9al prote9 bodies pres5t 9 ! meat juice dur+ ! process ( manufacture4 ,!y are highly nutriti\s & l>gely & readily absorb$ f ! alim5t>y canal1 b ! am\nt ( ^! bodies pres5t 9 ! trade products is relatively small except+ 9 ,bov99e1 :i* is n a meat juice1 p>ticul>ly :5 ! high prices are consid]$4 ,a consid]able proportion ( ! nitrog5\s matt] conta9$ 9 ,val5t9e's & ,wye?'s products is pres5t 9 ! =m ( am9o bodies frequ5tly includ$ 9 ! g5]al t]m1 8extractives40 ,^! bodies may be oxidiz$ 9 ! body & ?us supply heat 9 a mann] simil> to alcohol1 b x %\ld be rememb]$ t !re /ill appe>s to be a wide diff]5ce ( op9ion among v>i\s obs]v]s on ?is po9t4 ,"s appe> to be ( ! op9ion t ! am9o bodies are devoid ( food value 9 t ^! bodies appe> 9 ! ur9e practically un*ang$4 ,x w\ld1 !re=e1 appe> t ! value ( ! am9o bodies is l>gely ( a /imulant "*4 ,! food value ( meat juices1 !re=e1 resides l>gely1 if n solely1 9 ! coagulable & o!r prote9 mat]ial pres5t4 ,comp>+ ! calorific value or pot5tial en]gy available 9 meat juices prop] on ?is basis ) t pres5t 9 ! comm]cial products1 exclud+ ,bov99e1 x w be se5 t on ! av]age ! g5u9e meat juices--t is1 ^? made by pressure1 direct f ! meat itself z want$--are mu* sup]ior to ! comm]cial products1 not)/&+ ! m>k$ conc5tration 9 "s cases4 ,! calories giv5 9 ! accompany+ table d n include sug>1 alcohol or any o!r add$ mat]ial ( ?is "*4 ,,wye?',s ,,beef ,,juice 8,wye?'s ,beef ,juice0 is n a true beef juice1 b resembles r a dilut$ meat extract4 ,x conta9s mu* add$ inorganic matt]1 is l[ 9 coagulable prote9s1 & consid]+ ! degree ( conc5tration1 relatively defici5t 9 nutritive value4 ,"s ( ! claims conta9$ 9 ! circul> accompany+ ?is prep>ation1 9 view ( its composition set =? above1 may be ( int]e/3 8,wye?'s ,beef ,juice 4441 conta9+ two fluid ounces & repres5t+ ?ree p\nds ( prime lean beef14440 8444 beef extracts made by ! ,liebig process are utt]ly devoid ( ! valuable & nutriti\s album9\s con/itu5ts ( meat14440 ,wye?'s ,beef ,juice 8%\ld n be comp>$ ) ord9>y beef extract14440 ,,composition ,,( ,,meat ,,juices ,,column ,,head+s3 #a ,"n ( ,prep>ation #b ,p] c5t4 volatile matt] #ajj ,c4 #c ,p] c5t4 inorganic matt] #d ,p] c5t4 sodium *lorid #e ,p] c5t4 phosphoric p5toxid 7,p#b,o#e7 #f ,p] c5t4 e!r extract1 glyc]ol & undet]m9$ matt] #g ,p] c5t4 total nitrog5 #h ,p] c5t4 coagulable prote9s 7,n #f4be7 #i ,p] c5t4 o!r prote9s 7,n #f4be7 #aj ,am9o bodies 7,n #c4ab7 #aa ,calories p] #ejj gm4 obta9$ f prote9 factor #d4h #ab ,calories p] #ejj gm4 obta9$ f am9o bodies factor #j4ef #a #b #c #d #e #f #g #h #i #aj #aa #ab ---------------------------------------- ----------------------------- ,,trade ,,products3 ,*uck beef1 cold press$ #hf4he #a4hf 4#bj 4#ca #a4cba4gdf4ac #b4id 4#ijbag4fh #b4eb ,r\nd beef1 cold press$ #he4gf #a4ec 4#ab 4#cg 4#geb4jhh4ef #b4cga4jcbfb4cb #b4hh ,*uck beef press$ at #fj ,c4 #ia4ij #a4bi 4#ai 4#bi 4#haa4jib4ef #b4ej 4#hdaba4dd #b4ce ,*uck beef press$ at #fj ,c4 #hi4ef #a4bg 4#af 4#cg #b4iha4jic4jj #b4fc 4#eface4ab #a4eg ,r\nd beef press$ at #fj ,c4 #ij4fe #a4cf 4#af 4#cf #b4jia4afd4be 4#caa4cdaji4dd #c4ge ,*uck beef heat$ six h\rs be=e press+ #ih4aa 4#ci 4#je 4#ab 4#be 4#bd4444 #a4jj 4#be #bd4jj 4#gj #fj-ajj ,c4 ,,made ,,9 ,,laboratory3 ,beef ,juice1 ,john ,wye? ,bro41#eh4hdaf4baf4gac4bgab4eac4aeb4hh #c4eff4jjaed4efaf4hj ,philadelphia1 ,pa4 ,v ,bov99e1 ,! ,bov99e ,co41 #ge ,w4 ,h\/on ,/41#hj4dj #a4eea4je 4#ji #c4fdb4cfc4chaj4ge 4#bhcci4ab 4#gh ,new ,york ,city ,w ,x ,c>m9e ,co41 ,lefranco1 ,p>is1 ,france2 ,import$ by ,f\g]a ,co41 ,ag5ts1 ,new ,york #bd4hj 4#hf 4#ji 4#ccfh4id 4#ifb4be #b4ef 4#eiaae4dd #a4fe ,city ,y ,z ,meat ,juice1 ,m4 ,j4 ,val5t9e1 #eg4fdaj4bfa4ggc4dabj4dac4jf 4#ai #e4ddf4jface4abaf4ig ,ri*mond1 ,va4 ,,aa ,,ab ---------------------------------------- ----------------------------- ,v ,includ+ #j4bj p] c5t4 z ,,nh#c2 ,w #h4ag p] c5t4 alcohol f\nd2 ,x #c4a p] c5t4 glyc]ol f\nd2 ,y vacuum #gj ,c42 ,z #dg4ej p] c5t4 cane sug>--#ad4b p] c5t4 glyc]ol f\nd2 ,,aa #h p] c5t4 ( glyc]ol f\nd4 ,,ab includ+ #j4bb p] c5t4 ,,nh#c2 ,! sev]al samples ( beef juice 7 prep>$ f practically fat free1 f9ely comm9ut$1 *uck & r\nd beef1 fir/ by pressure at ! ord9>y temp]ature2 second1 by heat+ ! prep>$ meat = sev]al h\rs at #fj ,c41 !n submitt+ to pressure4 ,sample ,no4 #f 0 made f *uck beef1 prep>$ z above1 by heat+ six h\rs at f #fj to #ajj ,c41 & express+ aft] cool+4 ,x is n a beef juice prop] b 0 prep>$1 analyz$ & add$ to ! li/ = in=mation4 ,its composition resembles sev]al comm]cial articles closely4 ,a numb] ( products repres5t$ & sold z meat juice 9 ! ,unit$ ,/ates 7 analyz$ & ! results record$ 9 ! accompany+ table4 ,,bov99e ,bov99e1 adv]tis$ z a 8cond5s$ beef juice prep>$ by a cold process0 is a mixture ( alcohol1 glyc]91 add$ sodium *lorid1 & app>5tly "s =m ( defibr9at$ blood4 ,accord+ to ! manufactur]'s lit]ature egg album9 0 us$ =m]ly b ?is +r$i5t is said to be no long] employ$4 ,x is n a meat juice 9 any s5se ( ! ^w4 ,num]\s misrepres5tations w be f\nd on ! label & 9 ! lit]ature ( ,bov99e1 ( :i* ! foll[+ are typical3 8,! blood ( select$ /e]s prep>$ by a cold process1 furni%+ a p]fect food1 free f insoluble elem5ts40 8,! rapidity ) :i* ,bov99e is absorb$ & assimilat$ 9 ! /oma* 4440 8,x supplies complete nutrition to ! pati5t40 8,bov99e conta9s all ! elem5ts ( ! animal1 vegetable & m9]al k+doms = ! production ( new blood ) great rapidity4 ,its pr9cipal con/itu5ts h be5 select$ ) a view to furni% ! l>ge/ am\nt ( nutrim5t 9 ! mo/ cond5s$ =m & all ! res\rces ( mod]n *emical analysis h be5 br\ght to be> on ?is important problem40 ,a s]ies ( exp]im5ts c>ri$ out ) dogs "u ane/hesia1 by inject+ ,bov99e into ! /oma*1 ! pyloric end ( :i* 0 ligat$1 %[s t ,bov99e is n readily absorb$ & assimilat$ by ! /oma* z claim$4 ,! am\nt ( prote9 mat]ial f\nd 9 ! /oma* at ! end ( "o-half h\r to "o h\r & a qu>t] 0 practically equal to ! am\nt introduc$ by ! ,bov99e4 ,x is also repres5t$ t ,bov99e is ( great s]vice 9 case ( an irritable /oma*4 ,?is is n borne out by exp]im5t4 ,bov99e f$ to dogs by ! m\?1 ei!r alone or mix$ ) food1 induc$ vomit+1 :i* 0 less m>k$ :5 ,bov99e 0 giv5 ) ! regul> diet4 ,an exam9ation ( ! ur9e ( ^! animals %[$ a m>k$ dim9ution ( ! am\nt ( indican1 :ile ! e!real sulphates 7 enorm\sly increas$1 bo? absolutely & relatively1 :5 ,bov99e 0 giv54 ,exp]im5ts on rabbits h %[n t ,bov99e inject$ into ! p]itoneal cavity 0 inv>iably foll[$ by l>ge quantities ( album9 9 ! ur9e1 :i* p]si/$ = f tw5ty-f\r to =ty-eight h\rs4 ,?irty to #ej c4c4 p] kilo giv5 by m\? daily caus$ emaciation & weakness2 9 "s cases1 irritation ( ! ga/ro-inte/9al canal1 ) dea? ( ! animal 9 f sev5 to twelve days4 ,,c>n9e ,c>n9e is a ,fr5* prep>ation import$ into ! ,unit$ ,/ates by ,f\g]a ,co41 ( ,new ,york ,city4 ,9 physical appe>ance x looks l highly conc5trat$ food1 b analysis %[s t x consi/s ( a small proportion ( defibr9at$ blood dissolv$ 9 a mixture ( syrup & glyc]ol1 ! :ole agreeably flavor$4 ,x is repres5t$ z a 8juice ( r>e meat1 prep>$ by cold process4 ,ea* tablespoonful repres5ts #ajj gm4 ( raw meat1 or #c-a_/b ounces40 ,x is cle> t ,c>n9e is n a meat juice 9 any s5se ( ! ^w4 ,,val5t9e',s ,,meat ,,juice ,val5t9e's ,meat ,juice resembles 9 physical appe>ance ta/e1 odor & by *emical analysis a dilut$ meat extract4 ,! nutritive value ( meat extracts is virtually nil1 z is well kn[n by ! m$ical pr(ession4 ,not)/&+ ! composition ( ,val5t9e's ,meat ,juice & ! fact t beef extract repres5ts little nutritive value1 ! manufactur] makes ! foll[+ mislead+ repres5tations3 8,! two-ounce oval bottle1 adopt$ = ! ,meat ,juice conta9s ! conc5trat$ juice ( f\r p\nds ( ! be/ beef1 exclusive ( fat2 or ! cond5s$ ess5ce ( "o & a half p9ts ( pure liquid juice :i* is obta9$ f ! fle% ( beef40 8,! use ( hot wat] ) ! ,meat ,juice *anges its "* & impairs its value40 ,italics 9 orig9al4--,ed4 ,! company mu/ c]ta9ly be aw>e ( ! fact t its product conta9s little1 if any1 coagulable proteids4 ,,conclusions ,9 conclusion3 ,nei!r ,bov99e nor ,c>n9e is a meat juice1 ! =m] is any?+ b palatable & ! latt] soon cloys4 8,val5t9e's ,meat ,juice0 & 8,wye?'s ,beef ,juice0 are virtually dilut$ meat extracts1 :i* are kn[n to possess little food value4 ,a physician dep5d+ on any ( ! =ego+ products to supply mat]ial n\ri%m5t1 9 case ( s]i\s illness1 is deceiv+ himself1 />v+ 8 pati5ts1 & may be less5+ _! *ances = recov]y4 ,if a pati5t recov]s :ile us+ ^! commodities1 x is c]ta9ly n due to ! food value conta9$ 9 !m--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #bj1 #aiji47 ,,val5t9e',s ,,meat ,,juice,,ac ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,,ac ,see also prec$+ report on ,meat & ,beef ,juices1 & article on ,meat ,extracts & ,meat ,juices1 p4 #dgj4 ,"s "t ago ! ,c\ncil au?oriz$ publication ( a report,,ac deal+ ) ! composition & claims made = a numb] ( ! m g5]ally adv]tis$ meat & beef juices4 ,among ^! 0 ,val5t9e's ,meat ,juice4 ,?is x 0 %[n 0 sold "u an incorrect "n1 ! claims = its composition 7 n tru?fully /at$ & its exploit]s made false & mislead+ claims 9 reg>d to its food value4 ,z ,val5t9e's ,meat ,juice is /ill widely adv]tis$ ! ref]ee 9 *>ge ( ?is class ( products deem$ a reexam9ation ( ! product advisable4 ,?is 0 made & on x 0 bas$ ! foll[+ report :i* has be5 submitt$ to ! ,c\ncil1 adopt$1 & its publication au?oriz$4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,y\r ref]ee has _h exam9$ rec5tly pur*as$ specim5s ( ,val5t9e's ,meat ,juice 7,val5t9e's ,meat ,juice ,company1 ,ri*mond1 ,va474 ,! exam9ation %[s t x has virtually ! same composition z t giv5 9 ! report ( ! ,c\ncil 8,meat & ,beef ,juices0 publi%$ 9 ,! ,j\rnal1 ,nov4 #bj1 #aiji4 ,x conta9s practically no coagulable prote9 mat]ial1 "o ( ! products *>act]i/ic ( a meat juice4 ,x is ess5tially a dilut$ meat extract4 ,! foll[+ /atem5t f\nd 9 =m] circul>s n[ seems to h be5 elim9at$3 8,! two-ounce oval bottle1 adopt$ = ! ,meat ,juice conta9s ! conc5trat$ juice ( f\r p\nds ( ! be/ beef1 exclusive ( fat2 or ! cond5s$ ess5ce ( "o & a half p9ts ( pure liquid juice :i* is obta9$ f ! fle% ( beef40 ,an endeavor is /ill made1 h[ev]1 to convey ! idea t ! product conta9s coagulable prote91 z %[n by ! foll[+3 8,boil+ wat] *anges ! "* ( ! prep>ation40 8,! use ( boil+ wat] ) ! ,meat-,juice *anges ! "* ( ! ,prep>ation40 ,! proprietors und\bt$ly "k t ! product does n conta9 any coagulable mat]ial & t ! /atem5ts j quot$ are pla9 misrepres5tations4 ,! adv]tis+ circul> conta9s a l>ge numb] ( 8,te/imonials ( ! ,m$ical ,pr(ession40 ,z all are undat$1 "o _c tell h[ old ^! te/imonials are4 ,"o physician recomm5ds x highly = hypod]mic use2 ano!r says1 8,i h kept cases on x & x alone = days1 )\t attempt+ to give any o!r food1 & ! results h be5 entirely satisfactory40 ,accord+ to ano!r1 x is 8mo/ invaluable 9 typhoid fev] & also 9 diph!ria40 ,val5t9e's ,meat ,juice conflicts ) ! foll[+ rules ( ! ,c\ncil3 ,rule #a1 9 t its composition is n correctly giv52 ,rule #f1 9 t unw>rant$ !rapeutic claims are made1 ! pr(ession be+ l$ to believe t ! product is highly nutriti\s & is valuable 9 ! treatm5t ( pneumonia1 diph!ria & typhoid fev]2 ,rule #h1 9 t ! "n is objectionable1 = :ile sold z a meat juice1 9 reality x has ! "* ( a meat extract4 ,val5t9e's ,meat ,juice is a fraud on ! public1 & 9 view ( its cont9u$ exploitation "u false claims1 ! ref]ee recomm5ds t ! ,c\ncil reit]ate its =m] condemnation & au?orize ! publication ( ?is report4 ,editor's ,note4--,! diff]5ce betwe5 meat extracts & meat juices 0 fully discuss$ 9 ! previ\s report ( ! ,c\ncil1 ,meat 8juices0 are made by ! cold expression ( meat ) subsequ5t evaporation1 9 su* a way t ! nutriti\s coagulable prote9s rema9 9 solution4 ,9 mak+ meat 8extracts10 heat is us$ :i* almo/ completely removes ! coagulable prote9s & ?us r5d]s x practically devoid ( nutri5t qualities4 ,a li/ ( "s ( ! m$ical j\rnals t c>ry adv]tisem5ts ( ,val5t9e's ,meat ,juice1 foll[s3 ,p$iatrics ,old ,dom9ion ,j\rnal ( ,m$ic9e ,surg]y ,m$ical ,_w ,virg9ia ,m$ical ,semi-,mon?ly ,m$ical ,times ,am]ican ,m$ic9e4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,may #b1 #aiad47 ,,m$ic9al ,,foods ,a report1 ( :i* ! foll[+ is an ab/ract1 0 submitt$ to ! ,c\ncil on ,ph>macy & ,*emi/ry by ! subcommittee :i* exam9$ ! m$ic9al foods3 ,9 ord] to det]m9e ! food value ( any food product x is necess>y to consid] ! foll[+ po9ts3 ,*emical composition2 available pot5tial en]gy2 absorbability & co/4 ,no attempt is made 9 ?is article to discuss ea* ( ^! features sep>ately1 b !y are utiliz$ z requir$4 ,! +r$i5ts on :i* ! food value ( any article ( food dep5ds are ! proteid sub/ances1 c>bohydrates1 fats1 c]ta9 inorganic bodies &--"u c]ta9 conditions--alcohol4 ,! am\nt ( ea* ( ^! pres5t 9 a prep>ation mu/ be e/abli%$ by *emical analysis4 ,f ! results ?us obta9$ x is possible to calculate ! pot5tial en]gy repres5t$ by a giv5 food product4 ,9 ?is report ! pot5tial or food value is express$ 9 ! l>ge or kilocalorie1 t is1 ! am\nt ( heat requir$ to raise ! temp]ature ( "o kilogram ( wat] "o degree c5tigrade4 ,! factors employ$ 9 ?is report = express+ 9 calories ! actual am\nt ( en]gy utiliz$ by ! sy/em are #d4h = proteid sub/ances1 #d4a = c>bohydrates1 & #i4b = fats4 ,! accompany+ table embodies ! results obta9$ by submitt+ all ! well-kn[n s-call$ 8pr$ige/$ foods0 to *emical exam9ation4 ,! table z publi%$ 9 ,! ,j\rnal includ$ columns on3 ,price ( bottle1 numb] ( cubic c5timet]s 9 a bottle1 co/ p] #ejj cubic c5timet]s1 reaction1 specific gravity1 p]c5tage ( non-volatile residue1 a%1 p]c5tage ( nitrog51 calories z proteids 9 #ejj grams1 c>bohydrates be=e inv]sion1 alcohol by volume1 av]age recomm5d$ adult dose p] diem 9 cubic c5timet]s1 co/ p] diem to supply #a1dcj calories4 ,^! columns 7 elim9at$ f ?is ab/ract1 z !y 7 uness5tial1 s f> z ! practical value ( ! article is conc]n$4 ,9 mo/ cases two samples ( ! same br& 7 pur*as$ at an int]val ( ab\t six mon?s4 ,all ! analyses 7 made be=e ,jan4 #a1 #aijg4 ,"s ( ! prep>ations conta9 mu* glyc]9 :i* does n1 s f> z kn[n at pres5t1 possess any recogniz$ food value1 al?\gh !re are a numb] ( exp]im5ts on record to indicate t x influ5ces metabolism4 ,! p]c5tage ( nitrog5 accr$it$ to ea* ( ^! products repres5ts ! total am\nt ( nitrog51 irrespective ( ! nature ( ! nitrog5\s sub/ances1 al?\gh "s ( ?is nitrog5 has no nutritive value4 ,by multiply+ ! p]c5tage ( nitrog5 f\nd by ! factor #f4be we obta9 ! p]c5tage ( nitrog5\s matt] 7proteids7 conta9$ 9 ! v>i\s prep>ations4 ,by multiply+ ! numb] ( grams ( nitrog5\s matt] pres5t 9 #ejj grams ( mat]ial by ! factor #d4h x is f\nd t ! pot5tial en]gy available by ! nitrog5\s matt] v>ies f #aj4c calories to #aec4a calories4 ,five hundr$ grams ( ! mat]ial is made ! basis ( calculation1 because x approximates a p9t1 ! am\nt usually believ$ to be pres5t 9 ! v>i\s trade packages1 & because x af=ds a ready basis ( calculation4 ,! c>bohydrates are repres5t$ by cane sug>1 maltose1 dextr9 & inv]t sug>4 ,lactose is probably also pres5t 9 "s1 b x is impossible to e/abli% ?is4 ,by multiply+ ! numb] ( grams ( c>bohydrates pres5t 9 #ejj grams ( ! foods by ! factor #d4a we obta9 ! pot5tial en]gy repres5t$ by ! c>bohydrate1 :i* v>ies f #aa4c to #cai4b calories4 ,! total calorific value ( bo? proteids & c>bohydrates ranges f #ed4g to #cig4e calories4 ,! total food value ( an equal quantity ( milk1 includ+ fat1 approximates #cfj calories4 ,! value ( alcohol z a food product pure & simple 9 disease is1 h[ev]1 an op5 "q4 ,!re is no d\bt :atev] b t x acts to a c]ta9 degree z a food ev5 "h1 n z a tissue build]1 b z a sav] ( fat & c>bohydrate mat]ial1 & 9 ord] to give ! prep>ations 9 "q full value z food products1 ! calories repres5t$ by ! alcohol1 are cr$it$ to ea* prep>ation1 z are ! proteids & c>bohydrates4 ,! factor usually recogniz$ = express+ ! calorific value ( alcohol is #g4 ,by multiply+ ! numb] ( grams ( alcohol pres5t 9 #ejj grams ( mat]ial by #g1 ! numb] ( calories v>ies f #dbj to #feh4 ,on look+ ov] ! lit]ature & pr9t$ matt] di/ribut$ by "s manufactur]s1 ! physician is frequ5tly left "u ! impression t ^! prep>ations conta9 all ! ess5tial con/itu5ts necess>y = ma9ta9+ normal nutrition ( ! body1 z is cle>ly %[n by ! foll[+ quotation3 8,conta9s suffici5t nutritive mat]ial to ma9ta9 normal nutrition ( ! body1 a valuable food 9 typhoid fev]1 pneumonia1 tub]culosis1 444 & all ! conditions ( ! sy/em associat$ ) enfeebl$ dige/ion & malnutrition40 ,9 ord] to %[ ! insidi\sness ( su* repres5tations x is only necess>y to give ! actual food value ( ! av]age daily dose 7! av]age am\nt to be tak5 = tw5ty-f\r h\rs7 recomm5d$ by ! v>i\s manufactur]s = _! products4 ,! av]age adult daily dose recomm5d$ v>ies f #ej to #aej c4c4 ,! total available calories p] daily dose bas$ on ! proteid & c>bohydrate bodies v>ies f #i4h to #aaj4e4 ,add+ to ^! figures ! am\nt ( en]gy repres5t$ by ! alcohol1 9 ea* case1 ! total available calories v>ies f #ee4j to #bii4e4 ,! numb] ( calories p] diem 9 sickness %\ld n fall mu* bel[ #a1ejj dur+ tw5ty-f\r h\rs4 ,,tabulat$ ,,results ,,( ,,exam9ations ,,( ,,m$ic9al ,,foods ,,column ,,head+s3 #a ,"n ( ,prep>ation & ,manufactur] #b ,glyc]9 & undet]m9$ matt] #c ,p] c5t nitrog5\s matt] 7#f4bf7 #d ,calories z proteids 9 #ejj grams #e ,c>bohydrates aft] inv]sion #f ,calories z c>bohydrates 9 #ejj grams #g ,calories z proteids & c>bohydrates 9 #ejj grams #h ,alcohol1 by weight #i ,calories z alcohol 9 #ejj grams #aj ,calories z proteids & c>bohydrates p] diem dose #aa ,total calories 9 p] diem dose,,ad #ab ,numb] c4c4 requir$ p] diem to supply #a1dcj calories #a #b #c #d #e #f #g #h #i #aj #aa #ab ---------------------------------------- --------------------------------- ,c>panutr9e --,john ,wye? #bh4ded4bhajb4g #e4cdaji4ebab4bab4edcg4e #be4e #gh4ja1ajj4g ,bro!r ,c>panutr9e --,john ,wye? #ba4bif4bdadi4h #e4ghaah4ebfh4cad4jdij4j #cb4b #ia4j #idb4i ,bro!r ,liquid ,peptones --,eli ,lilly #c4fcd4ejajh4j #f4jeabd4jbcb4jah4jfcj4j #fi4f #beh4f #hbi4d ,company4 ,liquid ,peptones1 ) ,creosote --,eli ,lilly #d4cdc4hd #ib4bac4dgbgf4acfh4cah4jfcj4jaaj4e #bii4e #gaf4b ,company ,nutri5t ,w9e ( ,beef ,peptone-- #ad4igj4fd #ae4dae4dccaf4ccca4gag4efab4e #ff4c #ahh4h #geg4d ,arm\r ,company ,nutri5t ,w9e ( ,beef ,peptone-- #ac4gjj4dc #aj4cae4egcai4bcbi4eag4jeie4j #fe4i #ahd4i #ggc4c ,arm\r ,company ,nutritive ,liquid ,peptone--,p>ke1 #a4jba4hf #dd4fab4hibfd4bcjh4hah4hfeh4j #gd4b #bcb4a #gci4e ,davis ,company ,nutritive ,liquid ,peptone--,p>ke1 #a4iea4af #bg4hac4aibgj4dbih4bag4gfai4e #ga4e #bbj4b #ggi4b ,davis ,company ,peptonic ,elixir --,wm4 ,m]rell #c4bab4ed #fa4jaa4dfbcd4ibie4iaf4eegg4e #ec4c #aeg4b #hah4f ,*emical ,company ,tonic ,beef ,s4 ,d4-- #ab4iac4dj #ha4f #b4cf #dh4dacj4jab4jdbj4j #ac4j #ee4ja1cjj4j ,%>p ,dohme ,tonic ,beef ,s4 ,d4-- #ab4fcc4bh #gh4g #b4bb #de4eabd4bac4jdee4j #ab4d #eg4ia1bcd4d ,%>p ,dohme ,liquid ,peptone --,/ev5son #j4dda4ha #dc4d #j4ee #aa4c #ed4gab4jdbj4j #i4h #he4da1ejf4h ,je/] ,company ,c['s ,milk 7#c4h p] c5t4 -- #c4ej #hd4j #d4hj #ih4dahb4d -- -- #g4ca1dbi4fb1jjj4j fat7 ---------------------------------------- --------------------------------- ,,ad ,total calories p] diem dose includes ! calories ( alcohol 9 ! liquid m$ic9al foods & ! calories ( ! fat 9 milk4 ,9 ord] to get a fair conception ( ! actual food value ( ^! v>i\s prep>ations1 x is desirable to make "s comp>ison :i* c be readily compreh5d$ by e physician4 ,! am\nt ( good milk necess>y ea* tw5ty-f\r h\rs to su/a9 ! vitality ( a pati5t dur+ a s]i\s illness is n less ?an #fd ounces1 or approximately #b1jjj c4c4 ,! food value 9 calories repres5t$ by ?is am\nt ( good milk may be plac$ at #a1dcj4 ,?is includes n only ! proteid & c>bohydrate matt]1 b ! fat z well4 ,by comp>+ ?is available pot5tial en]gy ) ! total en]gy available 9 ! pr$ige/$ foods "u consid]ation1 x c be readily se5 t if a physician dep5ds on ! repres5tations made by "s ( ! manufactur]s1 & fe$s 8 pati5t accord+ly1 he is resort+ to a />vation diet4 ,! l>ge/ numb] ( available calories1 includ+ alcohol1 pres5t 9 any ( ! recomm5d$ daily doses1 is less ?an "o-fif? ( ! numb] ( calories repres5t$ by #b1jjj c4c4 ( milk2 & ! calories repres5t$ by ! daily dose ( ! prep>ation poore/ 9 food products is only "o-tw5ty-fif? ( ! am\nt pres5t 9 #b1jjj c4c4 ( milk4 ,^! figures tell _! own /ory4 ,mak+ #b1jjj c4c4 ( milk ! basis ( calculation1 & e/imat+ ! am\nt ( ! v>i\s prep>ations requir$ to yield ?is numb] ( calories1 x is f\nd t ! quantity to be adm9i/]$ daily to supply #a1dcj calories1 includ+ alcohol1 v>ies f #gaf4b to #a1ejf4b c4c4 ,9 _m cases ! am\nt ( alcohol exhibit$ by ^! quantities w\ld keep ! pati5t 9 an alcoholic /upor cont9ually4 ,! co/ necess>y to supply ?is en]gy v>ies f #a4dh to #c4ci4 ,comp>e ^! prices ) ! co/ ( two qu>ts ( milk4 ,is fur!r comm5t necess>y8 ,x is urg$ 9 ju/ification ( ! use ( prep>ations ( ?is class t !y conta9 con/itu5ts n f\nd 9 our ord9>y foods & 9 a m p]fectly assimilable condition4 ,z po9t$ out above1 ^! s-call$ pr$ige/$ foods conta9 no fats2 ! c>bohydrates 9 !m are ! ord9>y sug>s pres5t 9 our common foods1 :ile ! prote9s belong to ! peptone or albumose class4 ,x is = ^! latt] t ! greate/ claims are made1 b ev5 "h no value c be po9t$ out n f\nd 9 :ey1 peptoniz$ full milk or peptoniz$ skimm$ milk4 ,!re is likewise ano!r po9t ( consid]able importance to consid] 9 ?is connection4 ,! t]ms peptone & albumose include bodies ( v unc]ta9 composition1 & _! suitabl5ess z food sub/ances dep5ds l>gely on h[ !y are prep>$4 ,animal exp]im5ts h %[n t nitrog5 equilibrium may be ma9ta9$1 = a "t at lea/1 by use ( enzymic hydrolytic products ( ! prote9s1 ev5 :]e ! hydrolysis has be5 c>ri$ f> beyond ! s-call$ peptone /age1 b x appe>s to be likewise true t ! mixtures secur$ by acid or high temp]ature /eam hydrolysis h no su* value4 ,"s ( ^!1 inde$1 may exhibit a toxic behavior4 ,?is is true 9 p>ticul> ( "s ( ! comm]cial v>ieties ( peptone1 & until m is kn[n ( ! s\rce ( ! bodies ( prote9 "* employ$ 9 ! makeup ( ^! 8pr$ige/$0 mixtures x is unwise to assume any?+ conc]n+ ! food value ( ! nitrog5 comp\nds f\nd 9 !m by analysis or ev5 to dignify !m by ! "n ( foods4--7,ab/ract$ f ,! ,j\rnal ,a4 ,m4 ,a41 ,may #aa1 #aijg47 ,,migra99 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil1 hav+ vot$ to resc9d ! acceptance ( ,migra99 & to omit x f ,new & ,non(ficial ,rem$ies 7,app5dix71 direct$ publication ( ! report giv5 bel[4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,,supplem5tal ,,report ,,on ,,migra99 ,to ! ,c\ncil3--,koe*l ,co41 ,am]ican ag5ts = ,migra99 7,mei/] ,lucius ,brun+7 ass]t$ t ?is prep>ation 0 a mixture ( antipyr9 #he p>ts1 caffe9 #i p>ts & citric acid #f p>ts4 ,! exp]im5ts ( ,f4 ,z]nik 7,apo?4-,ztg41 #aijf1 p4 #fhf71 h[ev]1 %[$ t ,migra99 consi/$ ( antipyr9 #ij4hh p>ts1 caffe9 #h4d p>ts & citric acid #j4de p>ts4 ,:5 ! att5tion ( ,koe*l ,co4 0 call$ to ?is !y in=m$ ! ,c\ncil1 on ,june #bj1 #aijg1 t ! =mula !y gave 0 giv5 !m direct by ! manufactur]s abroad & t !y1 ,koe*l ,co41 did n "q its accuracy4 ,!y1 h[ev]1 (f]$ to 8write abroad & h ! manufactur]s confirm ! =mula z giv540 ,on ,july #bc1 #aijg1 ,koe*l ,co4 wrote ! secret>y ( ! ,c\ncil t ! manufactur]s _h in=m$ !m t ,migra99 conta9s #ij p] c5t4 antipyr9 & #i4a p] c5t4 caffe9 citrate4 ,?is be+ an ackn[l$gm5t t ! =m] /atem5t submitt$ 0 incorrect1 ! ,c\ncil vot$ t ! approval ( ,migra99 %\ld be reconsid]$4 ,exam9ation ( ! product1 !re=e1 0 tak5 up 9 ! ,association's laboratory & an orig9al specim51 pur*as$ 9 ,*icago1 0 f\nd to conta9 moi/ure #j4g p] c5t41 antipyr9 #ij4ic p] c5t41 & in/ead ( caffe9 citrate #i4a p] c5t41 citric acid #j4ea p] c5t41 caffe9 #h4ec p] c5t4 ,?is analysis agre$ ess5tially ) ! composition ( ,migra99 z f\nd by ,z]nik4 ,:ile ! discrepancies betwe5 ! /atem5t ( ! firm & ! facts are p]haps n great1 nev]!less !y %[ t ev5 ! =mula la/ giv5 is incorrect1 & t ! /atem5ts ( ,koe*l ,co41 :ile no d\bt made 9 good fai?1 7 9 ?is in/ance unreliable4 ,9 rec5t adv]tis+ matt] issu$ by ,koe*l ,co41 8ph5ozon-caffe9 citrate0 is giv5 z a synonym = ,migra991 "o circul> /at+ t 8,migra99 is ph5ozon-caffe9 citrate10 etc4 ,9 ! same circul> ! foll[+ also appe>s3 8,9 ! treatm5t ( migra9e ) ph5acet9 or antipyr91 ! attack is delay$1 :ile ) ,migra99 x is usually p]man5tly /ay$40 ,?is w1 no d\bt1 lead physicians to inf] t ,migra99 is n a mixture ( antipyr9 & caffe9 citrate1 b t x is "s new comp\nd4 ,:ile ! firm disclaims any int5tion to mislead1 x does n (f] to )draw or modify ?is circul>4 ,x is recomm5d$1 !re=e1 t ! approval ( ,migra99 be resc9d$ & t x be omitt$ f ,new & ,non(ficial ,rem$ies4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,june #e1 #aiji47 ,,neurilla ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! foll[+ report 0 adopt$ by ! ,c\ncil4 ,its publication 0 au?oriz$ to %[ h[ a practically wor?less mixture may be exploit$ by means ( ill-consid]$ te/imonials4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,neurilla1 :i* appe>s to be ! sole product ( ! ,dad ,*emical ,company1 ,new ,york1 is adv]tis$ z 8,! ,ideal ,n]ve ,calmant40 8444 a n]ve tonic 444 indicat$ 9 cases :]e ! n]ve c5t]s are poorly n\ri%$ & ov]-s5sitive 4440 8444 a /imulant to ! n]v\s sy/em40 8,a ,valuable ,aid 9 ! ,treatm5t ( ,fev]s1 ,colds1 ,la ,grippe1 etc40 ,! foll[+ non-quantitative & indef9ite =mula is giv5 on ! label ( a rec5tly pur*as$ bottle ( ,neurilla3 8,prep>$ f ,scutell>ia ,lat]iflora1 ,passiflora ,inc>nata & ,aromatics40 8,proportion ( ,alcohol #bj4c4 8,made by ,dad ,*emical ,co41 ,new ,york1 ,u4 ,s4 ,a4 8,dose1 ,"o ,teaspoonful ,f\r ,times a ,day40 ,accord+ to ! =mula1 !n1 ?is mixture conta9s1 aside f alcohol & aromatics1 two vegetable drugs1 scutell>ia & passiflora1 on :i* ! alleg$ virtues ( ! prep>ation mu/ be presum$ to dep5d4 ,scutell>ia lat]iflora1 or skullcap1 is a bitt] drug1 "o ( ! _m 8h]bs0 to :i*1 on :olly unreliable 8cl9ical evid5ce10 !rapeutic prop]ties 7 at "o "t ascrib$4 ,mo/ ph>macologi/s d n m5tion ! drug1 & ^? :o d g5]ally /ate t x has v feeble !rapeutic prop]ties4 ,x 0 admitt$ to ! ,ph>macopeia1 b 9 #aiji its deletion 0 recomm5d$ by a committee ( ! ,section on ,practice ( ,m$ic9e ( ! ,am]ican ,m$ical ,association 7,! ,j\rnal ,a4 ,m4 ,a41 ,sept4 #d1 #aiji1 p4 #gib74 ,we und]/& t ! next edition ( ! ,ph>macopeia w omit m5tion ( skullcap4 ,passiflora inc>nata1 or passion-fl[]1 is ano!r 8h]b10 :i*1 al?\gh kn[n = ab\t sev5ty ye>s1 has nev] ga9$ ! confid5ce ( ! m$ical pr(ession & has n ev5 be5 admitt$ to ! ,ph>macopeia4 ,accord+ to a ,c\ncil ,report3 8,none ( ! evid5ce is suffici5t to %[ t passiflora has !rapeutic value2 h5ce x is deem$ inadvisable to include ! drug 9 ! li/ ( non(ficial rem$ies0 7,! ,j\rnal ,a4 ,m4 ,a41 ,m>* #ai1 #aiaj1 p4 #ihc74 ,on ^! two obsolesc5t 8h]bs10 !n1 re/ ! rem>kable claims made = ,neurilla4 ,a c]ta9 degree ( appetiz+ effect may be expect$ f ! bitt] ta/e & a v slight degree ( physical /imulus f ! alcohol4 ,except = ^! effects--& !y are l>gely delusive & tempor>y--! prep>ation is !rapeutically in]t & wor?less4 ,! evid5ce on :i* ! manufactur]s ( ,neurilla base _! !rapeutic claims appe>s to consi/ ( te/imonials f physicians4 ,z a matt] ( fact1 ?is is true ( practically all ( ! l>ge gr\p ( no/rums ( :i* ,neurilla is typical4 ,an analysis ( ^! ,neurilla te/imonials br+s out cle>ly :at su* 8evid5ce0 is wor?4 ,,ill-,,consid]$ ,,te/imonials ,! te/imonials = ,neurilla h be5 giv5 ) ref]5ce to indef9ite conditions ( n]v\sness t bord] on ! psy*ic & include hy/]ia1 neura/h5ia1 neuralgia & ! l4 ,n]v\sness & indige/ion are two diseases 9 :i* sugge/ion1 especially :5 aid$ by bitt]s & alcohol1 produces tempor>ily a feel+ ( improvem5t4 ,z an illu/ration1 take ! foll[+ te/imonial3 8,b m /rik+ 0 ! foll[+ case3 ,"o ev5+ betwe5 #e & #f o'clock ,i 0 s5t =1 family lives ne> me1 & ,i 0 in=m$ t ! "y lady _h promis$ to be bridesmaid1 a function %e _h nev] p]=m$4 ,h] "m said ! daught] w\ld c]ta9ly drop 9 h] tracks z %e walk$ up to ! alt> ) ! procession1 & !y _h ab\t conclud$ to s5d a note say+ to ! p>5ts ( ! bride t %e c\ld n come1 al?\gh t w\ld be v disagreeable 7& no less (f5sive1 said ,i74 ,!y agre$ ) me4 ,i ord]$ ,neurilla = two h\rs4 ,%e w5t to *ur*1 &1 ,i 0 in=m$ ! next morn+1 pass$ ?r\gh ! dread$ ordeal simply fatigu$1 & 0 n[ fa/ asleep on acc\nt ( ! nice effect ( ,neurilla40 ,x might provoke a smile to ?9k t a manufactur] w\ld publi% s silly a te/imonial 7 x n t ! v fact ( its publication indicates t !re are m$ical m5 ?\ghtless en\gh to read & accept su* /uff z reliable evid5ce z to ! value ( any product4 ,,te/imonials ,,giv5 ,,long ,,ago--,,! ,,rem$y ,,ab&on$ ,a numb] ( physicians :o _h giv5 te/imonials 7 ask$ 9 writ+ :e!r ! te/imonials 7 g5u9e & :e!r !y /ill ent]ta9$ ! high op9ion ( ,neurilla express$ at a =m] date4 ,sev]al repli$ t1 if !y _h ev] giv5 su* te/imonials1 !y _h =gott5 ! circum/ance4 ,f ! replies receiv$ we select ! foll[+3 ,! te/imonial :i* be>s ,dr4 ,a's "n reads3 8,i am us+ ,neurilla ) mo/ satisfactory results40 ,dr4 ,a n[ says3 8,z to its positive value z a !rapeutic ag5t ,i h n us$ x en\gh to "k4444 ,if ! language y quote 444 appe>s z giv5 9 or z a #8te/imonial' x mu/ 9 "s way be g>bl$ & appe>s :olly )\t my k or cons5t40 ,dr4 ,b is quot$ z hav+ writt53 8,i d n (t5 l5d my influ5ce to fur!r+ ! fame ( a propriet>y rem$y1 b ,i h a*iev$ su* excell5t results f ! use ( ,neurilla z a calmative 9 hy/]ia & o!r n]v\s disord]s1 t ,i feel its manufactur]s are entitl$ to an ackn[l$gm5t ( gratitude f me40 ,dr4 ,b writes3 8,i h n prescrib$ a dose ( ! no/rum 9 ye>s4 ,! use ( my "n 9 connection ) ,neurilla is unau?oriz$40 ,dr4 ,c once wrote3 8,i h us$ ,neurilla ) good results40 ,dr4 ,c n[ writes3 8,9 re #8,neurilla' ,i ?9k ,i us$ ! prep>ation once or twice & x seem$ to d good "w1 b if due to ! prep>ation or o!r influ5ces1 ,i am n able to v]ify4 ,i h n us$ x s9ce nor w1 z ,i am oppos$ to us+ ^! prep>ations except 9 c]ta9 cases :]e ! conta9s rem$ies ^: value ,i h v]ifi$ "u ! mo/ rigid te/s4 8,p4 ,s4 ,?is te/imonial mu/ h be5 giv5 _m ye>s ago40 ,dr4 ,d's te/imonial is admitt$ to be bas$ on a s+le case3 8,i am us+ ,neurilla 9 a bad case ( neuralgic tic ) v good results on an ag$ lady4 ,%e has tak5 sev]al bottles1 & is /ill tak+ x ) v good results40 ,dr4 ,d sums up 8 lat] exp]i5ce by say+3 8,i h long s9ce ab&on$ ! use ( ,neurilla 9 practice40 ,! foll[+ be>s ,dr4 ,e's "n3 8,i endorse ,neurilla )\t hesitation4 ,x meets all indications = :i* x is int5d$40 ,?is is :at ,dr4 ,e writes n[3 8,z to ! enclos$ te/imonial 9 reg>d to ,neurilla said to be writt5 by me ,i h no recollection4 ,i am n prescrib+ ,neurilla40 ,dr4 ,f's exp]i5ce is simil>4 ,! te/imonial cr$it$ to him reads3 8,i h prescrib$ ,neurilla 9 n]v\s disord]s ) good results40 ,dr4 ,f n[ writes3 8,i don't rememb] ( ev] hav+ prescrib$ #8,neurilla' or ( hav+ giv5 a te/imonial = x or any o!r pat5t m$ic9e if ,i knew x to be s40 ,,summ>y ,9 ! booklet f :i* ! =ego+ are tak51 !re are =ty te/imonials4 ,^? :i* we quote are m]ely samples4 ,to sum up ! results ( ?is analysis3 ,( ! te/imonials "s are said to be unau?oriz$2 a numb] 7 writt5 ) s little ?\ght t ! writ]s _h s9ce =gott5 _! v exi/5ce2 ! conclusions express$ 9 mo/ are n 9 fact ju/ifi$ by ! writ]s' mature judgm5t & exp]i5ce4 ,a numb] ( writ]s admit t _! exp]i5ce is insuffici5t to det]m9e :e!r ! suppos$ good results 7 due to ! m$ic9e us$ or to o!r influ5ces4 ,( c\rse su* evid5ce is unwor?y ( cr$it & happily1 v little is n[ be+ furni%$ by doctors2 ev5 our c\rts refuse to admit x4 ,9 %ort1 ! publi%$ =mula %[s t ,neurilla is no?+ m ?an a prep>ation ( discr$it$ drugs2 x is exploit$ l>gely by means ( c>elessly =m$ & ?\ghtlessly express$ op9ions ( physicians4 ,x is recomm5d$ t ?is report be publi%$ z an illu/ration ( su* me?ods & z a prote/ aga9/ !m4 ,editorial ,comm5t4--,neurilla is adv]tis$ 9 ! foll[+ publications3 ,ar*ives ( ,p$iatrics1 ,atlanta ,j\rnal ,record ( ,m$ic9e1 ,*>lotte ,m$ical ,j\rnal1 ,indianapolis ,m$ical ,j\rnal1 ,int]national ,j\rnal ( ,surg]y1 ,j\rnal ( ,n]v\s & ,m5tal ,diseases1 ,m$ical ,h]ald1 ,new ,york ,m$ical ,record1 ,m$ical ,review ( ,reviews1 ,m$ical ,s5t9el1 ,m$ical ,/&>d1 ,pacific ,m$ical ,j\rnal1 ,s\!rn ,practition]1 ,texas ,m$ical ,j\rnal1 ,woman's ,m$ical ,j\rnal1 ,eclectic ,m$ical ,j\rnal1 ,ell+wood's ,!rapeuti/1 ,j\rnal ( ! ,am]ican ,in/itute ( ,homeopa?y4 --7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,m>* #bg1 #aiad47 ,,neuros9e1 ,,dioviburnia1 ,,g]miletum ,,& ,,palpebr9e ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,neuros9e1 ,dioviburnia1 ,g]miletum & ,palpebr9e are 8%otgun0 propriet>ies typical ( ! polyph>macy ( ! pa/ ?ree or f\r decades4 ,!y are m>ket$ by ! ,dios ,*emical ,company1 ,/4 ,l\is1 ,mo4 ,on ! recomm5dation ( ! ref]ee1 ! ,c\ncil has au?oriz$ ! publication ( ?is report4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,neuros9e ,accord+ to ! manufactur]s1 ea* fluid\nce ( ,neuros9e repres5ts3 8,bromid ( potassium1 ,c4 ,p4 #dj gra9s 8,bromid ( sodium1 ,c4 ,p4 #dj gra9s 8,bromid ( ammonium1 ,c4 ,p4 #dj gra9s 8,bromid ( z9c #a gra9 8,extract ,lupul9 #cb gra9s 8,casc>a sagrada1 fl4 ex4 #dj m9ims 8,extract ,h5bane 4#jge gra9 8,extract ,belladonna 4#jge gra9 8,extract ,cannabis indica 4#fj gra9 8,oil ,bitt] ,almonds 4#jfj gra9 8,aromatic ,elixirs40 ,no physician w\ld ?9k = a mom5t ( prescrib+ all ( ! drugs conta9$ 9 ,neuros9e = any "o condition4 ,yet physicians are urg$ to use ?is no/rum 9 insomnia1 hy/]ia1 neura/h5ia1 migra9e1 neuralgia1 delirium trem5s & 9 a ho/ ( o!r conditions4 ,x is recomm5d$ 9 ! treatm5t ( epilepsy on ?is gr\nd3 8,neuros9e is pres5t$ 9 a v palatable & agreeable =m & c be adm9i/]$ = an indef9ite "t )\t unt[>d by-effects z s (t5 att5ds ! use ( ! comm]cial bromides4 ,9 ord] to secure la/+ b5efits ! treatm5t %\ld be ext5d$ ov] a long p]iod ( "t40 ,! evid5t implication "h is t ! recogniz$ drawbacks ( bromid m$ication are due to impurities pres5t 9 ! comm]cial bromids & t ! tea*+s ( mod]n m$ic9e ) reg>d to caution 9 ! use ( bromids d n apply 9 ! case ( ,neuros9e4 ,! assurance is (f]$3 8,neuros9e conta9s no *loral1 morph9 or o!r objectionable drug--a fact ( ! utmo/ importance :5 adm9i/]+ m$ic9es to neurotic wom540 8,z a n]ve-calmative & sleep-produc] no?+ c excel ,neuros9e 444 ,x %\ld be borne 9 m9d t ?is prep>ation conta9s no opium1 morph9e1 *loral or habit-=m+ drugs 444 ,neuros9e be+ a h>mless rem$y is especially indicat$ = neurotic individuals40 ,ap>t f cannabis indica1 ,neuros9e conta9s no effici5t hypnotic4 ,cannabis indica is a dang]\s drug1 ^: adm9i/ration to 8neurotic individuals0 is by no means free f dang]--especially :5 x is giv5 "u a propriet>y "n t c>ries no w>n+ ( its pres5ce4 ,"h is ano!r recomm5dation--?is "t = *orea3 8,all au?orities recomm5d ! bromides1 hyoscyamus & cannabis indica 9 ?is disease4 ,^! rem$ies are all comb9$ 9 ,neuros9e1 ! ideal calmative = bo? *ildr5 & adults40 ,on ! contr>y1 practically 8all m$ical au?orities0 w admit t x is undesirable to keep a *ild "u ! influ5ce ( bromids if ?is c be avoid$4 ,su* treatm5t is m5tion$ only = use z a la/ resort 9 extreme cases4 ,hyoscyamus & cannabis indica are m5tion$ 9 connection ) *orea by few au?orities1 & !n m]ely z probably valueless4 ,n cont5t ) recomm5d+ ! promiscu\s use ( ?is already too complex mixture1 ! ,dios ,*emical ,company advises physicians to comb9e x ) iron1 :5 *alybeate & tonic effects are to be comb9$ ) 8a n]v9e10 ) acetanilid = 8irritable c\gh10 heada*e & neuralgia1 ) antipyr9 9 a/hma & ) ,dioviburnia--ano!r ,dios no/rum--9 all female ailm5ts4 ,dioviburnia,,ae ,,ae ,= articles on o!r viburnum prep>ations1 see pp4 #bah & #dji4 ,dioviburnia1 ano!r ,dios no/rum1 accord+ to ! label1 has ! foll[+ composition3 8,e fl4 oz4 conta9s #c-d dr4 ea* ( ! fl4 extracts1 ,viburnum ,prunifolium1 ,viburnum ,opulus1 ,dioscorea ,villosa1 ,aletris ,f>9osa1 ,helonias ,dioica1 ,mit*ellae sic ,rep5s1 ,caulophyllum ,?alictroides1 ,scutell>ia ,lat]ifolia40 ,lat]iflora8--,ed4 ,fur!r1 accord+ to ! label1 ,dioviburnia conta9s #ah p] c5t4 alcohol4 ,if ?is /atem5t is correct !n ! 8=mula0 is false1 = ! fluid extracts nam$ conta9 f #be to #gc p] c5t4 ( alcohol4 ,z--accord+ to ! 8=mula0--^! fluid extracts con/itute ?ree-f\r?s ( ,dioviburnia1 ! av]age alcohol-cont5t 9 ! :ole mixture mu/ ( necessity be mu* above #ah p] c5t4#ei ,accord+ to ! mak]s1 ,dioviburnia is 8unexcell$0 =3 8,am5orrhea1 ,dysm5orrhea1 ,leucorrhea1 ,pu]p]al ,convulsions1 ,prolapsus ,ut]i1 ,m5orrhagia1 ,?reat5$ ,abortion1 ,p>turition1 ,sub9volution1 ,misc>riage1 & a g5]al relax$ condition ( ! ut]us & app5dages1 toge!r ) ! v>i\s a*es & pa9s peculi> to wom540 #ei ,five ( ^! fluidextracts h _! alcohol-cont5t det]m9$ by ! ,ph>macopeia or ,national ,=mul>y4 ,?ree are n recogniz$ & h5ce _! alcohol-cont5t is n def9$ by law4 ,! alcohol-cont5t ( ! mixture ( fluidextracts said to be 9 ,dioviburnia has be5 k9dly furni%$ by five lead+ ph>maceutical h\ses4 ,if ! l[e/ alcohol-cont5t ( ! sev]al fluidextracts is made ! basis ( calculation1 ,dioviburnia %\ld conta9 at lea/ #cj4ge p] c5t4 ( alcohol1 or m ?an half z mu* aga9 z ! am\nt decl>$ on ! label4 ,ar\nd ! sample bottle ( ,dioviburnia is wrapp$ a booklet entitl$ 8,a ,treatise on ,ut]9e ,diseases & ,ob/etrical ,h9ts10 said to be 8,= ! ,pr(ession ,only40 ,! booklet has be5 prep>$1 physicians are told1 to pres5t 8"s v valuable sugge/ions0 reg>d+ ! treatm5t ( female disord]s & ! att5tion ( ! m$ical pr(ession is 8e>ne/ly0 call$ to ! 8v rem>kable m$ic9e10 ,dioviburnia4 ,fur!r1 x is said t ,dioviburnia 0 devis$ by ! ,dios ,*emical ,company because !re 0 an 8absolute necessity0 = "s really effici5t int]nal treatm5t 9 female diseases4 ,! company backs up its /atem5ts by su* claims z3 8,! mo/ valuable prep>ation1 !rapeutically1 ev] (f]$40 8,conta9s e ess5tial = ton+ up ! female organs ( g5]ation1 & reliev+ pa940 8,a g5]al & special tonic1 antispasmodic & invigorat+ cordial40 ,:ile ! company directs ! att5tion ( physicians to ! 8well-kn[n1 !rapeutical effects ( ea* individual con/itu5t0 ( ,dioviburnia1 !re is 9 reality little positive evid5ce reg>d+ ! action ( any ( ! drugs conta9$ 9 ! no/rum4 ,mo/ writ]s on mat]ia m$ica d n ev5 m5tion ^! drugs & ! few :o d discuss !m1 ei!r "q or d5y _! m$ic9al value4 ,b if e drug claim$ to be pres5t 9 ,dioviburnia _h "s actual demon/rat$ !rapeutic prop]ties1 x /ill w\ld be impossible to pr$ict ! action ( su* a comb9ation 9 ! _m & v>i$ conditions = :i* x is exploit$4 ,c]ta9ly !re is no w>rant = su* /atem5ts z3 8,9 ,pa9ful ,dysm5orrhea sic ,dioviburnia is especially indicat$1 & its cont9u$ use w inv>iably give relief40 8,9 cases ( ,leucorrhea ( long /&+1 ,dioviburnia1 toge!r ) local treatm5t1 inv>iably gives relief40 8,dioviburnia is effici5t 9 cases ( sub9volution2 x cures by its tonic effects44440 ,! effects ( ! drugs alleg$ to be pres5t 9 ,dioviburnia are n su* z to ju/ify ! hope ( ei!r 8cure0 or 8inv>iable relief40 ,9 a way ! ,dios ,*emical ,company seems to recognize ! ineffici5cy ( ,dioviburnia s9ce x frequ5tly sugge/s t x be us$ 9 comb9ation ) drugs ( kn[n value2 b x ascribes all favorable results to its own product3 8,9 *ronic con/ipation fluid extract ( casc>a sagrada aromatic may be comb9$ ) ,dioviburnia40 8,9 cases ( habitual abortion1 dep5d+ on syphilitic ta9t1 a prescription conta9+ ! foll[+ %\ld be us$ dur+ ! entire pregnancy3 8,hydr>g4 ,*lor4 ,corros gr4 #a 8,potass4 ,iodid dram #a 8,dioviburnia ounces #af0 8,an ,anemic or ,*lorotic pati5t1 suff]+ ) abs5ce ( ! m5/rual fl[1 %\ld take ,,dioviburnia comb9$ ) ,iron40 8,9 leucorrhea dep5d+ on endoc]vicitis1 hot a/r+5t d\*es once daily %\ld be giv54 ,local applications ( iod9 are useful 9 *ronic conditions4 ,int]nally1 ,d i o v i b u r n i a promotes heal+40 8,re/ 9 b$1 hot d\*es ( a "o-half p] c5t4 solution ( comp\nd cresol solution & ,d i o v i b u r n i a int]nally1 a teaspoonful e #c h\rs w r>ely fail to cure endometritis 9 a few days40 8,9 specific vag9itis1 a solution ( potassium p]manganate 7#a to #ajjj7 %\ld be us$ z a d\*e twice daily4 ,int]nally give ! foll[+3 8,sodii b5zoate #a_/b ounce 8,dioviburnia #af ounces 8,m4 sig41 ,teaspoonful e ?ree h\rs40 8,prolapsus ,ut]i is b5efit$1 & (t5 cur$1 by ,,dioviburnia comb9$ ) local treatm5t 9 ! %ape ( tampons1 pess>ies1 electricity1 etc40 ,if ,dioviburnia w cure specific vag9itis1 anemia1 etc41 s w a cobble/one make excell5t s\p4 ,all t is necess>y 9 ! =m] case is to add c]ta9 pot5t drugs t might be indicat$ 9 ! pa?ologic conditions m5tion$ &1 9 ! latt] case1 to comb9e suitable am\nts ( beef1 *ick51 gre5 turtle or vegetables1 ) h]bs & o!r season+4 ,g]miletum ,g]miletum is a memb] ( ! l>ge class ( alkal9e antiseptic solutions ) excessively complex =mulas4 ,9 ?is case n only is ! =mula complex b also ! ,dios ,*emical ,company f9ds x impossible ev5 to assign a con/ant composition to x--at lea/ ! 8=mulas0 :i* appe> on ! diff]5t /yles ( ,g]miletum labels & adv]tis+ circul>s v>y greatly4 ,! company says3 8,we appeal only to ! ,doctor's judgm5t ( 8 e/imation ( ! =mula40 8,doctor y w readily det]m9e f ! =mula ! class ( cases 9 :i* y h a "r to expect satisfactory results40 ,yet ! 8=mulas0 giv5 pres5t s great a v>iety & su* confusion t x is n cle> ev5 to a *emi/ j :at ! ,dios ,company wants ! m$ical pr(ession to reg>d z ! composition ( ,g]miletum4 ,! foll[+ /atem5ts ( 8composition0 h appe>$ at v>i\s times3 #a4 ,9 an adv]tis+ circul> s5t out "s "t ago3 8,,hbf#d ,,boh 7,,oc#f;,h#d;,,cooh7#b ,,boh 7,,oc#f;,h#c;,,cooh7#b ,c#c;,h#e;,,bo#c ,,*#b,o ,c#aj;,h#ad,o ,c#aj;,h#bj,o ,c#bd;,h#bh,n#c;,cl40 #b4 ,9 adv]tis+ circul>s :i* h be5 receiv$ ( late1 be+ wrapp$ ) a sample package & ) ! 8l>ge size0 trade package3 8,c#g;,h#f,o#b ,h#c;,,bo#c ,c#c;,h#e;,,bo#c 7,,*#b,o7#c ,c#aj;,h#bj,o ,c#aj;,h#ad,o ,c#b;,h#f,o0 #c4 ,9 ano!r adv]tis+ circul>3 8,g]miletum is a slightly alkal9e *emical solution ( ,borohydr(luoric ,acid1 ,borosalylb5zoic ,acid1 ,boroglyc]9e1 ,=maldehyde ) ,m5?ol1 ,?ymol & ,antiseptic ,aromatics40 #d4 ,on ! label ( a sample package s5t ?r\gh ! mails dur+ #aiad1 & on ! label ( a 8small size0 trade package pur*as$ 9 #aiad3 8,,=mula4--,borohydr(luoric ,acid1 ,borosalylb5zoic ,acid1 ,boroglyc]9e1 ,=maldehyde ) ,m5?ol1 ,?ymol1 ,amyl ,acetate & o!r ,antiseptic ,aromatics40 #e4 ,9 ! circul> :i* 0 wrapp$ ar\nd ! sample package ref]r$ to above1 & ar\nd ! 8l>ge size0 trade package pur*as$ at ! same "t t ! 8small size0 package 0 b\ght3 8,g]miletum is a slightly alkal9e *emical solution ( ,borob5zoic ,acid1 ,boroglyc]9e ,=maldehyde1 ) ,m5?ol1 ,?ymol & o!r ,antiseptec sic ,aromatics40 #f4 ,on ! sample package1 on ! 8small size0 trade package & on ! wrapp]s ( ! 8l>ge size0 trade package3 8,alcohol #ah p] c5t42 ,=mal9 #c_/d ,m4 p] oz42 ,amyl ,acetate #a_/c ,m4 p] oz40 7also writt5 8,acetate ,amyl407 ,! label on ! l>ge trade package /ates t ,g]miletum conta9s 8,=mal9 #a_/b ,m4 p] oz40 ,"o & all ( ^! v>i\s =mulas spell my/]y4 ,! exi/5ce ( "s ( ! con/itu5ts is problematic2 ev5 if ! !oretical possibility ( su* comb9ations be conc$$1 "s ( !m c\ld n exi/ 9 ,g]miletum1 = !y w\ld be brok5 up by ! alkal9e fluid4 ,z illu/rat+ ! contradictions :i* ! =mulas pres5t3 ,:ile ! wrapp] ( ! 8l>ge size0 trade package claims t ,g]miletum conta9s #c_/d m9ims ,=mal9 7,=mal9 is a propriet>y "n = a #dj p] c5t4 =maldehyd solution7 ! label on ! bottle claims only #a_/b m9im4 ,aga91 :ile ! composition express$ 9 *emical symbols ass]ts t 8,h#c;,,bo#c0 7boric acid7 is a con/itu5t ( ,g]miletum1 ! 8=mula0 :i* foll[s x /ates t ,g]miletum has an alkal9e reaction2 h5ce x _c conta9 mu* boric acid4 ,f9ally1 ! 8small size0 bottle ( ,g]miletum pur*as$ at ! same "t z ! 8l>ge size0 bottle & also ! label ( a sample package s5t ?r\gh ! mails to a physician 9 #aiad1 give z a con/itu5t 8,borohydr(luoric ,acid10 :i* is m5tion$ nei!r on ! label ( ! 8l>ge size0 trade package nor 9 ! pamphlet wrapp$ ar\nd x4 ,! only in=mation :i* ^! contradictory 8=mulas0 c convey to a physician is t ,g]miletum is an unsci5tific1 v>y+ mixture ( _m drugs4 ,a trade package1 hav+ ! "n 8,g]miletum0 bl[n 9 ! glass1 be>s on ! label recomm5dations = its use 9 ! treatm5t ( 8cat>rh10 8,ga/ritis1 ,/omatitis1 ,ga/ric & ,inte/9al ,cat>rh10 8,leucorrhea & ,ut]9e ,diseases10 8,hemorrhoids10 8,:oop+ ,c\gh10 8,tonsilitis & o!r =ms ( sore ?roat0 & 8,eczema40 ,! foll[+ /atem5t on ! label is design$ to induce physicians to place false confid5ce 9 ,g]miletum to ! dang] ( _! pati5ts3 8,! ly+-9-room %\ld be ?or\ghly spray$ ) ,g]miletum4 ,c be reli$ ^u to de/roy ! liv+ p>ticles :i* s g5]ally con/itute contagion40 ,?is claim1 z well z ! ass]tion :i* appe>s on ! label ( a sample package & ( ! 8small size0 trade package t x is 8,,p>-,,excell5t ,,9 ,,ob/etrical ,,practice0 is almo/ crim9al1 z ,fussell#fj has said1 s9ce to dep5d on any prep>ation ( ?is sort is to c\rt disa/]4 #fj ,fussell1 ,m4 ,h43 ,dang]s ( ,c]ta9 ,e?ical ,propriet>y ,prep>ations to ,bo? ,physicians & ,public1 ,! ,j\rnal ,a4 ,m4 ,a41 ,oct4 #g1 #aiaa1 p4 #aaif4 ,! booklet ar\nd ! trade package makes ! claim t ,g]miletum 8is ! be/ antiseptic0--evid5tly l>gely because x is claim$ to be 8! bl&e/ ( all0--& t x is 8?or\ghly g]micidal0 & ev5 t x is 8! be/ dis9fectant obta9able40 ,x also conta9s su* unw>rant$ & mislead+ claims & sugge/ions z3 8444 prep>atory to all op]ative "w--,g]miletum %\ld be us$ freely 9 spray+ ! atmosph]e 4440 8,op]ative w\nds1 :e!r l>ge or small1 c be r5d]$ ?or\ghly antiseptic by freely spray+ !m ) ,g]miletum44440 8444 x may be giv5 int]nally 9 _m dyspepsias & 9 all zymotic diseases4444 ,9 su* conditions ,g]miletum is ! ideal int]nal antiseptic & dis9fectant40 ,9 ! pres5t adv]tis+1 no evid5ce :atev] is (f]$ = ! value ( ,g]miletum1 ! ,dios ,company cont5t+ itself ) unsupport$ claims & cant phrases su* z 8444 ! tru? is only rea*$ ?r\gh a f9al appeal to intellig5t practical exp]i5ce40 ,9 ! old circul>s only crude1 uncritical & mean+less te/s to e/abli% ! antiseptic value ( ,g]miletum are report$ & none :atev] z to its g]micidal action4 ,9 ! adv]tis+ matt] s5t out "s "t ago1 = in/ance1 7 giv5 8,microscopical1 ,bact]iological & ,*emical ,te/s1 ,comp>+ ,g]miletum ) ,c>bolic ,acid40 ,^! te/s h no value :atev]1 unless x be to %[ ! wor?lessness ( ! prep>ation4 ,?is is p>ticul>ly true z reg>ds a s]ies ( exp]im5ts on 8,g]miletum z a ,prev5tive ( ,lactic ,f]m5tation10 9 :i* "o "p ( ,g]miletum 9 ?irty p>ts ( milk did n prev5t f]m5tation4 ,su* effect z indicat$ is probably due to ! =maldehyd pres5t4 ,! te/s %[ ! absurdity ( us+ ! prep>ation = int]nal & ext]nal purposes4 ,! ref]ee *all5ges ! !rapeutic claims on ! basis t !y are extravagant & unsub/antiat$4 7,! ,*emical ,laboratory ( ! ,am]ican ,m$ical ,association reports t ! alkal9ity ( ,g]miletum corresponds approximately to a #a p] c5t4 borax solution47 ,palpebr9e ,accord+ to ! ,dios ,*emical ,company1 ,palpebr9e is 8,a ,reliable ,ext]nal ,ocul> ,antiseptic0 hav+1 x is said1 ! foll[+ composition3 8444 ea* fluid ounce conta9s #a_/aaf gra9 ,sulphate ( ,morphia1 #a_/g gra9 ,sulphate ( ,z9c1 #a_/aa gra9 ,bi-,*loride ( ,m]cury1 #e-c_/h gra9s ,boric ,acid1 #c_/d gra9 ,salicylic ,acid40 ,! ess5tial virtues ascrib$ to ,palpebr9e1 accord+ to its mak]s1 are its h>mlessness & its !rapeutic effici5cy due1 presumably1 to its complex composition3 8,att5tion is call$ to ! con/itu5ts ( ?is =mula1 ea* "o ( :i* is us$ by oph?almologi/s4 ,_! comb9ation 9 ,palpebr9e is su* z to bl5d _! action 9 a v happy mann]4 ,palpebr9e acts z an antiseptic1 an irritant1 an a/r+5t1 & a n]ve tonic to ! muc\s membrane ( ! eye40 8,palpebr9e is sup]ior 9 its action to ! rem$ies n[ 9 use4 ,x conta9s all ! con/itu5ts ( ,aqua ,conradi 444 ,b to ^! are add$ a numb] ( o!r ag5ts :i* w prove x to be ( mu* great] value & give x a broad] field = action40 ,9 all ext]nal afflictions ( ! eye ! free use ( ,palpebr9e is sugge/$ 9 su* /atem5ts z3 8,!y g5]al practition]s w !re=e gladly receive f our h&s an efficaci\s prep>ation :i* may be us$ ) p]fect safety40 8,! "n ( our prep>ation--,palpebr9e1 is d]iv$ f ! ,lat9 palpebra1 ! eyelid1 & is well fitt$1 z x designates at a glance ! sph]e ( action ( ,palpebr9e40 8,) ! assi/ance ( ,palpebr9e ! g5]al practition] c successfully treat all cases ( ext]nal eye disease ord9>ily enc\nt]$ 9 8 practice40 ,"o ( ! memb]s ( ! ,c\ncil /aff ( cl9ical consultants calls att5tion to ! fact t mu* vitally valuable "t might be lo/ 9 a case ( iritis1 = example1 :i* be+ unrecogniz$1 %\ld be treat$ ) ,palpebr9e on ! /r5g? ( ! ,dios ,*emical ,company's adv]tisem5ts4 ,ev5 m dang]\s is ! recomm5dation ( ,palpebr9e = ! prev5tion ( oph?almia 9 ! newborn1 especially z ?is recomm5dation is c\pl$ ) an attempt to discr$it ! e/abli%$ treatm5t ) silv] nitrate solution3 8,! use ( sev]e rem$ies = ?is purpose has be5 disc>d$ by mo/ physicians44440 ,:ile x is d\btless true t oph?almia neonatorum may be av]t$ by o!r drugs ?an silv] salts1 x is utt]ly unju/ifiable to sugge/ t ! e/abli%$ me?od ( treatm5t by means ( silv] salt irrigations has be5 g5]ally disc>d$4 ,editorial ,note4--,! f\r no/rums m5tion$ above h be5 gr\p$ toge!r = publication to call att5tion to "o phase ( ! propriet>y bus9ess4 ,a fact n m5tion$ 9 ! ,c\ncil's report is t ^! no/rums are manufactur$ & promot$ by a conc]n t belongs to a type we h (t5 designat$ 8pseudo-*emical0 companies4 ,by ?is is meant companies t are n 9 ! legitimate bus9ess ( ph>macy or *emi/ry1 b organiz$ to exploit "o1 two or 9 "s in/ances half a doz5 propriet>ies4 8,pat5t m$ic9es0 are exploit$ by ?is class ( 8companies40 ,! ,dios ,*emical ,company is n a *emical company1 except 9 "n4 ,j4 ,h4 ,*amb]s1 ! f\nd] s f> z we c le>n1 nev] claim$ any special k ( *emi/ry1 ph>macy or m$ic9e4 ,! (fic]s at ! pres5t "t are3 ,j4 ,h4 ,*amb]s1 presid5t2 ,m4 ,e4 ,*amb]s1 vice-presid5t2 ,leslie ,t4 ,*amb]s1 treasur]1 & ,ar?ur ,*amb]s1 secret>y4 ,m4 ,e4 is ! wife ( ,j4 ,h41 & ,leslie ,t4 & ,ar?ur are sons4 ,?is is simply "o illu/ration ( ! fact not$ above4 ,"s physicians h be5 & are prescrib+ no/rums orig9at$1 manufactur$ & adv]tis$ by laym5 :o are n 9 ! legitimate ph>macy bus9ess4 ,9 addition1 su* physicians h be5 accept+ ! /atem5ts ( laym51 n only z to ! composition ( ! no/rums1 b z to _! use4 ,9 e /ate ! practice ( ph>macy is regulat$ by law3 be=e assum+ ! responsibility ( comp\nd+ m$ic9es a druggi/ mu/ h /udi$ & pass$ an exam9ation 9 ph>macy4 ,public safety dem&s & ! law requires x4 ,!re are "s doctors1 h[ev]1 :o w all[ laym5 :o are n *emi/s1 ph>maci/s or physicians to =mulate & comp\nd a prescription & tell !m :at x is good = & h[ to use x4 ,! ,dios ,*emical ,company is n an isolat$ in/ance3 we h already ref]r$ to "s2 we %all take occasion to ref] to o!rs 9 ! future4 ,t su* conc]ns fl\ri% is a reflection n s mu* on ! %rewd laym5 :o exploit ! m$ical pr(ession--& ?r\gh x ! public--z x is on ! physicians :o ca/ _! sci5tific tra9+ to ! w9ds & p]mit !mselves to be ?us exploit$4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #i1 #aiae47 ,,oxy*lor9e ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! foll[+ report on ,oxy*lor9e has be5 submitt$ to ! ,c\ncil by ! subcommittee to :i* x 0 assign$3 ,to ! ,c\ncil on ,ph>macy & ,*emi/ry3--,y\r subcommittee submits ! foll[+ report3 ,! ,oxy*lor9e ,*emical ,company1 #acbf ,waba% ,av5ue1 ,*icago1 /ates 9 its adv]tis+ lit]ature t3 8,*emically1 ,oxy*lor9e is ! tetraborate ( sodium & potassium comb9$ ) oxy*lorid ( boron1 ?us3 #f 7,na,k,b#d,o#g7 ,b,o,cl#c40 ,analysis ( ,oxy*lor9e %[$3 ,potassium #ab4bf p] c5t4 ,sodium #h4bj p] c5t4 ,*loric acid--,,clo#c #be4cb p] c5t4 ,nitric acid--,,no#c #ba4gj p] c5t4 ,boric acid anhydrid--,b#b,o#c #ah4fc p] c5t4 ,wat]1 calculat$ #ac4bi p] c5t4 ,?us1 ,oxy*lor9e is n a def9ite *emical sub/ance ( ! composition claim$1 b in/ead is a mixture ( alkali *lorate & nitrate ) boric acid4 ,assum+ t ! *lorate is pres5t z potassium *lorate & ! nitrate z sodium nitrate1 ! analysis above quot$ corresponds to a mixture approximately z foll[s3 ,potassium *lorat #cg4ai ,sodium nitrate #bi4gf ,sodium & potassium tetraborate #b4ah ,boric acid #cj4eb ,undet]m9$ #j4ce ------ #ajj4jj ,y\r committee recomm5ds t ,oxy*lor9e be n approv$ & t ?is report be publi%$4 ,! report ( ! subcommittee 0 adopt$ by ! ,c\ncil1 & 9 accordance ) ! recomm5dation is publi%$ h]e)4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,9 comm5t+ on ! above report x is h>dly necess>y to call att5tion to ! palpable untru?fulness ( ! furni%$ =mula or its lack ( correspond5ce to ! real composition ( ! prep>ation1 to ! impos+ claims made by its pseudo-sci5tific exploit]s or ! absurdities1 f a *emical /&po9t1 ( ! /atem5ts made 9 _! lit]ature4 ,^! features are m or less common to all no/rums4 ,! physician :o prescribes or uses ,oxy*lor9e "u ! impression t he is gett+ a def9ite & unique *emical comp\nd describ$ z tetraborate ( sodium & potassium comb9$ ) oxy*lorid ( boron is1 accord+ to our *emi/s1 gett+ simply a mixture ( potassium *lorate1 sodium nitrate 7or1 p]haps1 sodium *lorate & potassium nitrate71 & boric acid 9 ab\t equal am\nts4 ,m ?an "o-?ird ( ?is mixture is potassium 7or sodium7 *lorate1 drugs by no means h>mless4 ,9 ord] t !re may be no suspicion ( unfairness to ! promot]s ( ! prep>ation1 we quote f "o ( ! adv]tis+ circul>s s5t out by ! ,oxy*lor9e ,company3 8,oxy*lor9e owes its recognition z a !rapeutic ag5t to its six pr9cipal qualities3 8#a4 ,x w oxyg5ate ! blood at ! seat ( application1 ma9ta9 nutrition & heal an un9fect$ solution ( cont9uity ( fir/ int5tion )\t sc> =mation4 8#b4 ,x w disorganize all pus & f]m5t-produc+ micro-organisms1 _! tox9s1 f]m5ts & ptoma9s4 8#c4 ,x w re/ore an inflam$ muc\s membrane to its normal condition1 except :]e ! membrane is scl]os$ or atrophi$4 8#d4 ,x w de/roy pa?og5ic micro-organisms & _! tox9s 9 ! blood curr5t4 8#e4 ,x w /imulate ! blood to absorb m oxyg5 9 ! lungs ?an x at ! "t c>ries4 ,we d n "k :at ?is means2 p]haps ! ,oxy*lor9e ,company does4 8#f4 ,x is absolutely h>mless to ! tissues & w n de/roy a liv+ cell40 ,surely ^! p mu/ h access to physiologic & *emical au?orities n f\nd 9 mod]n m$ical libr>ies1 or else _! esot]ic rese>*es into ! my/]ies ( life mu/ h c>ri$ !m f> beyond ! k5 ( our mo/ advanc$ work]s along ^! l9es4 ,! sci5tific _w w\ld receive ) great int]e/ in=mation z to h[ a mixture ( potassium *lorate1 sodium nitrate & boric acid oxyg5ates blood1 ma9ta9s nutrition & causes heal+ )\t sc> =mation4 ,a mixture :i* w de/roy micro-organisms & yet w n de/roy a liv+ cell c]ta9ly %[s a f9e s5se ( selection & discrim9ation n h]et(ore expect$ ( a comb9ation ( *emicals or ( a *emical comp\nd4 ,h[ l ! wond]ful elixir ( m$ieval times1 :i* 0 to ! ,*ri/ian a tonic & to ! hea!n a poison6 ,"h is ano!r claim made = ?is no/rum3 8,two or ?ree rectal injections ( a "o or two p] c5t4 solution ( ,oxy*lor9e & t5 gra9 doses giv5 six to eight times p] day is ! be/ & mo/ reliable treatm5t = typhoid fev]40 ,if #hj gra9s ( ,oxy*lor9e conta9 #cj gra9s ( potassium *lorate1 ?ree rectal injections ea* consi/+ ( #a p9t ( #b p] c5t4 solution1 w\ld conta9 approximately #afj gra9s ( potassium *lorate4 ,su* an injection might prove decid$ly dang]\s1 especially :5 us$ by "o ignorant ( its true composition4 ,h[ev]1 ! physician1 n ! promot]s1 be>s ! responsibility4 ,oxy*lor9e sells at #c4ej a p\nd2 ! +r$i5ts c be obta9$ = ab\t #dd c5ts a p\nd4 ,p]haps ! m>g9 ( pr(it is int5d$ z a rew>d due ! promot]s = ! pr(\nd physiologic discov]ies ann\nc$ 9 _! read+ matt]4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,july #f1 #aiji47 ,,pam-,,ala1 ,,ano!r ,,wor?less ,,qu99 ,,sub/itute ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! foll[+ report ( a ref]ee on ,pam-ala1 an ass]t$ mal>ia specific1 0 adopt$ by ! ,c\ncil & its publication au?oriz$4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,soon aft] publication ( ! ,c\ncil's report on ,s9k9a1 an alleg$ mal>ia specific prov$ wor?less1 ! ref]ee's att5tion 0 call$ to ,pam-ala1 :i* is sold "u v simil> claims4 ,accord+ to ! adv]tisem5ts :i* h be5 appe>+ 9 ,s\!rn m$ical j\rnals1 ,pam-ala is 8,a new & effective rem$y = ,,mal>ia40 ,! label describes ,pam-ala z 8,an ,effective ,vegetable ,rem$y ,= ,,mal>ia4 ,gu>ante$ free ( any ,qu99e1 or o!r h>mful sic drugs40 ,x is said to be indicat$ 9 8,mal>ial ,int]mitt5t & ,remitt5t ,fev]s1 especially curative 9 ,*ronic ,mal>ia & ,mal>ial ,ca*exia & all conditions ev5 :]e ,qu99e fails40 ,"o tablespoonful ?ree times a day is said to be ! 8,curative ,dose10 :ile "o tablespoonful ?ree times a week is /at$ to be a 8,prophylactic ,dose40 ,! label fur!r claims t ,pam-ala 8,surpasses ,qu99e 9 its action & has none ( its ,disadvantages40 ,ass]tions t ,pam-ala is sup]ior to qu99 are foll[$ by ! usual 8gu>antee0 claim3 8,gu>ante$ by ! ,pam-,ala ,co4 "u ! ,drugs ,act1 ,june1 #aijf1 ,s]4 ,no4 #biji ,a40 ,f9ally1 ! label says t x is 8,endors$ by ,m$ical ,au?orities ,?r\gh\t ! _w40 ,z reg>ds ! composition1 a circul> says t 8,,pam-,,ala is a purely vegetable rem$y = ! cure1 )\t ,qu99e1 ( all =ms ( ,mal>ia40 8#8,,pam-,,ala' is d]iv$ f a plant ( ! g5us ,umbellif]ae1 a native ( ! m\nta9\s regions ( ,mexico & nor!rn p>ts ( ,s\? ,am]ica4 ,its m$ic9al prop]ties h n be5 kn[n to anyone b ! native ,indians1 :o = ye>s pa/ h us$ x z a specific 9 all =ms ( fev] & mal>ial diseases s preval5t 9 tropical c\ntries4 ,! se$s are m active z a !rapeutic ag5t ?an ! dri$-up plant2 h5ce _! collection = m$ic9al purposes requires special skill 9 ! selection ( ! same s z to be able to extract all ! possible m$ic9al prop]ties f !m1 viz41 its active pr9ciple4 ,an oil may be ab/ract$ f ! se$s :i* is ( a yell[ color ) an int5se *>act]i/ic odor40 ,at ! close ( ! circul> ! foll[+ un5light5+ =mula appe>s3 ,ea* fluid ounce conta9s3 ,ext4 ,fid4 ,pam-ala #aj p] c5t4 ,alcohol #ae p] c5t4 ,ol4 ,aurant ,syr4 ,sac*>i aqua ad4 q4 s4 #ajj p] c5t4 ,9 addition to be+ a cure = mal>ia1 ,pam-ala is claim$ to h a 8favorable influ5ce ^u ! bron*o-pneumonia ( measles 44410 8w av]t an attack ( acute cat>rh10 & 8abort acute tonsilitis40 ,! te/imonials are ( ! usual "*4 ,mo/ ( !m seem to h be5 giv5 "s f\r ye>s ago by physicians 9 ,italy1 ,cuba1 ,porto ,rico1 ,guatemala1 etc41 & !re=e _c readily be look$ into4 ,two are ( m rec5t date & come f physicians 9 ?is c\ntry4 ,!y furni% good illu/rations ( ! mann] 9 :i* propriet>y conc]ns make use ( op9ions ha/ily =m$ & ?\ghtlessly put 9 writ+4 ,"o te/imonial 0 giv5 9 ,july1 #aiab3 8,i take pleasure 9 te/ify+ to ! seem+ly m>vel\s & gratify+ effect ( ,pam-ala 9 #b cases ( mal>ia44440 ,on ,jan4 #b1 #aiad1 its writ]1 9 reply to an inquiry :e!r 9 ! light ( cont9u$ exp]i5ce1 8 fir/ e/imate ( ,pam-ala _h be5 confirm$1 wrote3 8444 ,s9ce !n ,i tri$ ,pam-ala on a numb] ( cases )\t any results :atev]2 9 fact my pati5ts seem$ to get worse until ,i resort$ to ! usual treatm5t ( mal>ia1 m]curial laxative foll[$ ) qu994 ,i 0 too ha/y 9 /at+ t ,pam-ala cur$ mal>ia4 ,i n[ "k & h kn[n s9ce ,augu/1 #aiab1 t ,pam-ala w n cure mal>ia44440 ,! writ] ( ! second te/imonial is report$ to h writt5 t he tri$ ,pam-ala 8on a mo/ pron\nc$ case ( mal>ial sple5 ) ! mo/ excell5t results0 & t he 8also tri$ ,pam-ala on a case ( ,mal>ial ,cy/itis & ,hematuria1 ) entire satisfaction40 ,9 reply to inquiry ?is physician admits t he 0 8v favorably impress$ ) ! prep>ation at ! "t40 ,he /ates t at t "t he 0 also try+ out ,s9k9a & t aft] six mon?s he 8discont9u$ ! use ( bo? z ! results did n w>rant fur!r inve/igation40 ,he concludes3 8,) due all[ance = ! fact t c]ta9 cases w = a "t improve on any k9d ( treatm5t1 new or old1 ,i see no reason = supplant+ or ev5 augm5t+1 ! recogniz$ treatm5t = mal>ial conditions1 ) ei!r ,pam-ala or ,s9k9a40 ,incid5tally x %\ld be m5tion$ t ?is physician also not$ ! g5]al simil>ity ( ,s9k9a & ,pam-ala4 ,he obs]ves3 8,! physical appe>ance & prop]ties ( ! two prep>ations seem to be id5tical1 ! adv]tis+ matt] & lit]ature are surpris+ly alike & ! only m>k$ diff]5ce seems to be t "o rem$y is purport$ to be prep>$ f a #8new' ,s\? ,am]ican plant & ! o!r f an equally fre% discov]$ addition to ,asiatic flora40 ,,:at ,,is ,,pam-,,ala8 ,f a comp>ison ( ! /atem5ts reg>d+ ! composition :i* are made = ,s9k9a & = ,pam-ala1 z well z f ! physical *>act]i/ics ( ! prep>ation1 p>ticul>ly ! odor & ta/e1 x seems evid5t t ! ess5tial con/itu5t is oil ( cum94 ,al?\gh def9ite pro( t oil ( cum9 =ms ! ess5tial con/itu5t ( ,pam-ala w\ld h %[n ! wor?lessness ( ?is no/rum = ! reason t ! cl9ical inve/igation ( ,s9k9a prov$ ! wor?lessness ( oil ( cum91 x did n seem wor? :ile to ! ref]ee t ?is be demon/rat$ by *emical analysis4 ,x seem$ to him t 9 su* cases z ^!1 ! secrecy ) :i* ! id5tity ( ! prep>ation is surr\nd$1 z well z ! extravagant & highly improbable claims1 %\ld be suffici5t to condemn x4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,feb4 #bh1 #aiad47 ,,papayans ,,bell,,af ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,,af ,see also ,bell-,ans 7,papayans ,bell71 p4 #bhb4 ,! foll[+ report ( a subcommittee 0 submitt$ to1 & adopt$ by1 ! ,c\ncil & its publication direct$4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,papayans 7,bell7 made by ,bell ,co41 ,orangeburg1 ,n4 ,y41 is said to consi/ ( ! 8dige/ive pr9ciple obta9$ by our own exclusive process f ! fruit ( ,c>ica papaya1 comb9$ ) will[ *>coal1 *emically pure sodium bic>bonate & aromatics40 ,! foll[+ /atem5t appe>s on ! package3 8,= ! treatm5t ( dyspepsia1 flatul5ce1 nausea1 v]tigo1 hyp]acidity1 palpitation & o!r symptoms ( indige/ion & ! vomit+ ( pregnancy4 ,p]itonitis1 *ol]a morbus1 alcoholism & seasickness40 8,dige/s e v>iety ( food1 removes e symptom ( indige/ion1 re/ores ! entire dige/ive tract to a normal condition40 ,! dosage is recomm5d$ z foll[s3 8,f "o to ?ree tablets be=e meals1 or two h\rs aft] eat+4 ,9 sev]e cases1 ?ree tablets dissolv$ 9 hot wat] & repeat$ z necess>y40 ,a circul> :i* accompanies ! package details ! !rapeutic virtues ( ! prep>ation & conta9s :at purports to be extracts f m$ical j\rnals1 9 :i* ,papayans is recomm5d$4 ,exam9ation ( specim5s pur*as$ 9 ! op5 m>ket %[$ !m to conta9 ! foll[+ +r$i5ts3 ,*>coal1 sodium bic>bonate1 g+]1 sac*>9 & oil ( gaul!ria4 ,z ! product is said to conta9 papa91 ! pres5ce ( enzymes 0 te/$ =1 ) ! result t x 0 f\nd to possess nei!r proteolytic nor amylolytic prop]ties4 ,! results ( our exam9ation are 9 accord ) ! results obta9$ by a memb] ( ! ,c\ncil1 :o exam9$ ! product indep5d5tly1 & :o writes3 8,we h made "s ext5d$ te/s ) ,papayans ,bell1 & f9d t ! tablets consi/ ess5tially ( sodium bic>bonate & *>coal1 ) a little flavor+ matt]4 ,we f9d no dige/+ p[] = />* or egg album94 ,at any rate1 no appreciable *ange foll[s 9 ! album9 9 ?ree h\rs1 & no conv]sion to sug> 9 ! same "t1 or *ange ( />* to a po9t :]e ! iod9 reaction is weak5$4 ,! product seems to be practically in]t40 ,x is recomm5d$ t ,papayans ,bell be refus$ recognition1 & t publication ( ?is report be au?oriz$4 ,comm5t3 ,x w be rememb]$ t two o!r products ( ,messrs4 ,bell ,company h be5 discuss$ 9 ?is dep>tm5t3 ,salacet9 7,bell7#fa & ,sal-,codeia 7,bell74#fb ,salacet9 0 exam9$ ) sev]al 8syn!tics0 :i* all turn$ out to be m]e acetanilid mixtures4 ,salacet91 adv]tis$ z 8a comb9ation1 ) heat1 ( ,salicylic & ,glacial ,acetic ,acids & ,ph5ylam9e0 :5 exam9$ 80 f\nd to be a mixture & to conta9 ! foll[+ +r$i5ts approximately 9 ! proportion giv53 ,acetanilid #dc2 sodium bic>bonate1 #ba2 & ammonium c>bonate1 #bj40 ,sal-,codeia 7,salacet9-,code97 !re=e1 w\ld be ! same ) code9 add$4 #fa ,see p4 #cef4 #fb ,see p4 #ceg4 ,papayans 7,bell7 seems to be consi/5tly fulfill+ ! life-hi/ory ( ! av]age no/rum4 ,made ( well-kn[n drugs & inve/$ by its manufactur]s--or exploit]s--) virtues absurdly disproportionate to ! kn[n prop]ties ( ! alleg$ con/itu5ts ( ! no/rum1 ! prep>ation 0 introduc$ to ! _w via ! m$ical pr(ession4 ,) ! help ( ?\ghtless physicians1 aid$ by a skilful & aggressive adv]tis+ campaign & augm5t$ by ! 8free sample0 device1 ! bus9ess grew & prosp]$4 ,! bottles ) ! "n & address ( ! company bl[n 9 ! glass & ) ! v>i$ !rapeutic indications = ! no/rum pr9t$ bo? on ! label & on ! circul> 9 :i* ! bottle is wrapp$1 h c>ri$ ! manufactur]'s message to ! drug-tak+ public4 ,apropos ( ?is po9t1 ! rec5t 8lit]ature0 conta9s :at purports to be endorsem5ts ( ! no/rum by m$ical j\rnals4 ,?us !re is quot$ f ! ,new ,york ,m$ical ,j\rnal1 ,jan4 #b1 #aiji1 9 "p1 ! foll[+ recomm5dation3 8444 we v5ture to sugge/ to our read]s :o h n tri$ ?is rem$y t !y prescribe "o orig9al seal$ package ( ,papayans 7,bell7 & t !y c>efully note ! results f its use40 ,italics ours4--,ed4 ,hav+ se5 an 8orig9al seal$ package0 we believe t we c pr$ict ! 8results f its use40 ,on any pati5t n m5tally unbalanc$1 ! result w\ld be t ! next dose ( ,papayans 7,bell7 he ?\ght t he ne$$ w\ld be pur*as$ f ! druggi/ direct4 ,t su* results are n hypo!tical is evid5c$ by ! /atem5ts ( ! exploit]s ( ,papayans 7,bell7 t 8! annual sale n[ exce$s f\r hundr$ million tablets40 ,assum+ t /atem5t to be true1 x w\ld be necess>y = e physician 9 ! ,unit$ ,/ates to prescribe ov] ?ree ?\s& ( ^! tablets e ye>--if !y rea*$ pati5ts only ?r\gh ! physician6 ,! company's own figures indicate t ! "t is ab\t ripe to take c>e ( ?is va/ army ( self-drugg+ laym5 & rec5t circul> lett]s seem to recognize x4 ,! physician is notifi$ t druggi/s are n[ furni%$ ) ,papayans 7,bell7 89 seal$ packages ( ?irty & "o hundr$ tablets40 ,! m$ical man is told t ! firm has 8n =gott5 ! days :5 physicians' ord]s made our success possible0 & x says x is 8s9c]ely grateful to ! doctors :o gave u ord]s 9 ! days :5 we 7 /ruggl+ = recognition40 ,?is tacit admission ( ! value ( ! physician z an unpaid ag5t = no/rum h\ses %\ld be giv5 ?\ght by ^? physicians :o prescribe su* prep>ations4 ,:ile1 s f> z we "k1 ,bell ,co4 h n yet adv]tis$ 9 ! daily press1 !y are n av]se to furni%+ ! laity ) samples :5 reque/$4 ,an ,ohio physician s5t u ! foll[+ lett] receiv$ by a "y woman :o _h writt5 ask+ = samples3 ---------------------------------------- ------------------ ,miss ,x---- ,y----1 ,z----4 ,de> ,madam3 ,z reque/$1 we are mail+ y sample ( our ,papayans 7,bell7 = ,indige/ion4 ,if a suff]] f ,indige/ion1 we want y to give x a ?or\gh trial z direct$ & note rem>kable results t we believe y w get f its use4 ,k9dly write u if y are unable to obta9 x f y\r local druggi/1 z x is /ock$ by ne>ly e good drug/ore 9 ! ,unit$ ,/ates4 ,y\rs truly1 ,bell ,co4 ---------------------------------------- ------------------ ,evid5tly ,bell ,co41 :ile admitt+ t _! f9ancial success is l>gely due to ! k9dly1 ?\gh misguid$1 ef=ts ( physicians1 are n go+ to let a little ?+ l loyalty to ! m$ical pr(ession int]f]e ) a possible sale ( _! tablets4 ,,! ,l4 ,d4 ,,johns ,,company ,a discussion ( ! me?ods ( ,bell ,company w\ld n be complete )\t ref]5ce to a conc]n :i* seems to be closely connect$ ) x3 ! ,l4 ,d4 ,johns ,company1 ^: 8only product0 is a sug>-coat$ laxative tablet4 ,reg>d+ ! 8sug> coat$0 tablet1 a visitor at ! place ( bus9ess ( ,bell ,company & ! ,l4 ,d4 ,johns ,company wrote3 8,^! companies app>5tly are n 9 possession ( any tablet coat+ ma*9es & 9 que/ion+ on ?is po9t /at$ t "s ( _! tablets 7 s5t out to be coat$40 ,!re is a sam5ess reg>d+ ! claims = ! laxative tablets ( ! two companies t might lead "o to suspect t ! same individual prep>$ bo? circul>s4 ,= in/ance3 ,,casc>ans 7,,bell7 8,tak5 z direct$1 x p]man5tly removes ! great majority ( cases ( habitual con/ipation40 8444 a h>mless vegetable prep>ation40 8444 = ! removal ( pimples1 yell[ness & greas9ess ( ! sk9 4440 8444 "o tablet at night1 "o night & morn+1 or1 9 sev]e cases1 "o ?ree "t a day1 gradually decreas+ ! frequ5cy ( ! dose z improvem5t p]mits40 ,,dr4 ,,johns' ,,tablets 8,tak5 z direct$ 444 p]man5tly remove ! great majority ( cases ( habitual con/ipation1 torpid liv] & sick heada*e40 8,a h>mless vegetable rem$y40 8444 removes pimples1 blot*es1 sall[ness & greas9ess ( ! sk9 4440 8,"o at night1 "o night & morn+1 or1 9 sev]e cases1 "o ?ree times a day4 ,gradually decrease ! frequ5cy ( ! dose z improvem5t p]mits40 ,accord+ to a leaflet s5t out ) samples by ! ,l4 ,d4 ,johns ,company1 ! company is capitaliz$ = #ejj1jjj1 divid$ into #ej1jjj %>es at #aj ea*2 ^! %>es are sold to ^? physicians :o w agree 8to prescribe ! tablets at e suitable opportunity1 to introduce !m to o!r physicians0 & 8to promote _! sale 9 e e?ical way60 ,if ! li/ ( physicians' names & addresses :i* ! company s5ds out z compris+ ! ea/]n /ockhold]s is to be reli$ on1 x w\ld seem t _m m$ical m5 are promot+ _! sale4 ,9 prescrib+ x is1 ( c\rse1 8necess>y to specify #8,dr4 ,johns' ,tablets ,no ,,xxx 7,orig9al bottle74'0 ,z ! "n is on ! bottle1 x is n unbelievable t1 z ! company says 9 its prospectus1 because ( 8our me?od ( adv]tis+1 a l>ge & v pr(itable bus9ess is be+ creat$40 ,t ! ,l4 ,d4 ,johns ,company expects to pr(it by ! self-drugg+ :i* ?is me?od ( prescrib+ fo/]s is evid5t3 8,physicians n /ockhold]s 9 ?is company suff] f ! cont9ual refill+ ( _! prescriptions & f ! recomm5dation ( ! prep>ation prescrib$ by pati5ts to o!rs4 ,italics ours4--,ed4 ,our /ockhold]s b5efit by ! refill+ ( _! prescriptions & by ^! recomm5dations40 ,put baldly ! case am\nts to ?is3 ,physicians :o prescribe 8,dr4 ,johns' ,tablets0 n only are likely to fo/] self-drugg+1 b !y w reap divid5ds !refrom4 ,truly a nice bus9ess to be 96 ,:ile ,bell ,company & ! ,l4 ,d4 ,johns ,company are said to be entirely di/9ct1 !y are to be f\nd at ! same address at ,orangeburg1 ,new ,york1 & z w be se51 ! (fic]s ( ! two companies are m or less relat$4 ,,bell ,,co4 ,l4 ,d4 ,,johns ,,co4 ,presid5t ,john ,l4 ,dodge ,presid5t ,secret>y ,geo4 ,c4 ,t5nant ,vice-,presid5t ,vice-,presid5t ,*as4 ,b4 ,smi? ,secret>y & ,treasur] ,,exploit+ ,,! ,,pr(ession ,no/rum promot]s h two simple ways ( 8work+0 ! m$ical pr(ession4 ,! fir/--& ! m pr(itable--is1 by lavi% di/ribution ( free samples1 to get physicians to prescribe ! bl[n-9-!-glass 8orig9al package0 ) ! inevitable result ( l>ge sales direct to ! laity4 ,by ! second me?od1 :i* is m]ely a modification ( ! fir/1 ! physician furni%es ! capital = float+ ! no/rum & !n takes 8 %>e ( ! result+ pr(its4 ,!re may n be q z mu* money 9 ! second me?od = ! promot]1 b !n ! risks are correspond+ly less4 ,if ! firm fails1 ! /ockhold]s are ! los]s2 ! promot] is n necess>ily 8out0 any?+4 ,f a comm]cial /&po9t1 a comb9ation ( ! two me?ods is1 ( c\rse1 ideal--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,aug4 #ad1 #aiji47 ,,passiflora ,,& ,,daniel',s ,,conc5trat$ ,,t9cture ,,( ,,passiflora,,ag ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,,ag ,see also ,pasadyne1 p4 #ccb4 ,! ,c\ncil has vot$ t ! drug passiflora 7passion fl[]7 be n accept$ = ,new & ,non(ficial ,rem$ies1 & has recomm5d$ t ! foll[+ article be publi%$ 9 ,! ,j\rnal4 ,x is consid]$ important to call att5tion1 n only to ! lack ( reliable evid5ce ( ! !rapeutic value ( passiflora1 b also to ! absurdity ( ! claims :i* are made = ,daniel's ,conc5trat$ ,t9cture ( ,passiflora1 a prep>ation :i* has be5 already refus$ recognition4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,passiflora ,al?\gh passiflora 0 introduc$ into m$ic9e ne>ly sev5ty ye>s ago1 ! lit]ature conc]n+ x is n v ext5sive2 x is n m5tion$ 9 ! /&>d works on ph>macology & its *emi/ry seems nev] to h be5 work$ out4 ,!re appe>s1 also1 to be no record ( exp]im5tal inve/igations ( ! drug ) ref]5ce to its ph>macologic action1 except an article by ,i4 ,ott1#fc :o us$ 8,daniel's ,conc5trat$ ,t9cture40 ,ott claim$ t x less5$ ! reflex irritability ( ! cord & p>alyz$ motion by act+ on ! motor c5t]s 9 ! cord1 & t x increas$ ! rate ( respiration4 ,he also /at$ t because ( its action on ! vasomotor c5t]s x r$uc$ ! frequ5cy ( ! he>t-beat & l[]$ art]ial t5sion1 b t ^! effects 7 only tempor>y4 #fc ,m$4 ,bull41 #ahih1 xx1 #deg-dfd4 ,on ! cl9ical side ! reports are n num]\s & su* z h be5 made d n appe> to be bas$ on v ext5sive trials nor on conditions ( obs]vation t w\ld entitle !m to m ?an slight consid]ation4 ,s4 ,d4 ,bull+ton#fd reports good results1 b no cure1 9 "o case ( epilepsy1 & improvem5t 9 a case ( insomnia4 ,w4 ,j4 ,/apleton#fe recomm5ds x 9 ! =m ( a conc5trat$ t9cture 7n ! "o adv]tis$ s ext5sively71 & /ates t he has us$ x ) great success 9 insomnia1 hy/]ia1 neura/h5ia1 neuralgia1 n]v\s & physical pro/ration1 & 9 alcoholism4 ,9 8 op9ion its action is mo/ app>5t 9 cases ( n]v\sness due to causes o!r ?an pa94 ,s4 ,h>nsb]g]#ff reports two cases 9 :i* p>tial bl9dness foll[$ ! tak+ ( potassium bromid & passion fl[]4 #fd ,na%ville ,j\r4 ,m$4 & ,surg41 #ahig1 lxxxi1 #ajg-aji4 #fe ,detroit ,m$4 ,j\r41 #aijd-e1 lv1 #ag4 #ff ,virg9ia ,m$4 ,semimon?ly1 #ahih-i1 iii1 #cib4 ,extravagant & inconsi/5t claims are made = ,daniel's conc5trat$ t9cture ( passiflora 9 ! adv]tis+ lit]ature1 :]e x is recomm5d$ = su* a wide range ( diseases z a/hma1 typhoid fev]1 convulsions & p>alysis4 ,none ( ! evid5ce is suffici5t to %[ t passiflora has !rapeutic value2 h5ce x is deem$ inadvisable to include ?is drug 9 ! li/ ( non(ficial rem$ies4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,m>* #ai1 #aiaj47 ,,liquid ,,comb9ations ,,conta9+ ,,peps9 ,,& ,,pancreat9,,ah ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ( ! ,am]ican ,m$ical ,association ,,ah ,see also ,reexam9ation ( ,lactopept9e1 p4 #aba4 ,a repr9t ( articles be>+ on ?is subject is issu$ "u ! title ,dige/ive impossibilities4 ,! foll[+ report 0 submitt$ to ! ,c\ncil by a subcommittee3 ,to ! ,c\ncil on ,ph>macy & ,*emi/ry3--,! ,u4 ,s4 ,ph>macopeia1 #h? revision1 pages #ccd-e1 /ates3 8,peps9 & pancreat9 9 solution are incompatible ) "o ano!r4 ,if ! solution be neutral or alkal9e ! pancreat9 gradually de/roys ! peps91 & if acid ! peps9 de/roys ! pancreat940 ,! correctness ( ?is /atem5t has be5 amply demon/rat$ by ! reports :i* h be5 submitt$ to ! ,c\ncil f "t to "t on liquid prep>ations claim$ to conta9 ^! two f]m5ts4 ,?us an elixir 0 inve/igat$ :i* 0 by ! manufactur]s claim$ to conta9 8! five active ag5ts ( dige/ion1 peps91 veg4 ptyal91 pancreat91 lactic & hydro*loric acids10 & to be 8sup]ior to all o!r rem$ies 9 dyspepsia & diseases aris+ f imp]fect dige/ion10 & ! committee :i* inve/igat$ ! article 9 "q report$ t 8x 0 impossible to e/abli% ! pres5ce ( ei!r ! proteolytic or ! amylolytic f]m5t40 ,simil>ly1 on ano!r liquid prep>ation1 :i* 0 said to conta9 8pancreat91 peps91 lactic & muriatic acids1 etc40 444 8! comb9$ pr9ciples ( dige/ion to aid 9 dige/+ animal & vegetable cook$ food1 fatty & amylace\s sub/ances10 ! committee report$ 8?is product possess$ only v slight proteolytic action & fail$ to dige/ #b p] c5t4 ( its own weight ( />*40 ,aga91 ! report on /ill ano!r prep>ation /at$3 8,b :ile x 0 said to conta9 pancreat91 ! ,u4 ,s4 ,p4 te/ = ! valuation ( pancreat9 fail$ to indicate ?is f]m5t40 ,! report on yet ano!r elixir1 claim$ to be 8! only true dige/ant1 because x conta9s ! enzymes ( all ! gl&s :i* are necess>y = dige/ion10 %[$ t ?is article did n conta9 8any appreciable enzyme activity1 ei!r amylolytic or proteolytic40 ,! correctness ( ^! f9d+s ( ! committee ( ! ,c\ncil 0 g5]ally ackn[l$g$ by ! manufactur]s :5 _! att5tion 0 call$ to ! matt]4 ,?us1 "o manufactur] ( dige/ive f]m5ts writes3 8,we w ask y to hold ?is matt] up until y he> f u fur!r on ! subject4 ,! reason = ?is reque/ is t we h be5 go+ ov] our liquid prep>ations v c>efully 9 ord] to be sure t aft] ag+ !y w\ld conta9 ! f]m5ts t we put into !m4 ,! pancreatic f]m5ts 9 alcoholic liquids seem to lose _! /r5g?40 ,! *emi/ = a l>ge manufactur+ h\se writes3 8,!re are n[ on ! m>ket a numb] ( prep>ations 9 :i* peps9 & pancreat9 are comb9$ 9 liquid =m1 & ! result is t we h _h numb]less requisitions f our repres5tatives t we also m>ket su* a prep>ation4 ,z ! result ( ?is we h c>ri$ out a s]ies ( exp]im5ts no less ?an f\r or five times 9 ord] to det]m9e :e!r peps91 dia/ase1 & pancreat9 w\ld reta9 _! activity 9 ! =m ( a syrup1 w9e or elixir4 ,we h prov$ incontrov]tibly t ?is _c be done4 ,:ile any two ( ^! sub/ances1 or ev5 all ?ree ( !m1 c be disp5s$ 9 ! =m ( a liquid by ! retail druggi/ & w reta9 _! normal activity = z long a p]iod z ?ree to six weeks1 yet if all[$ to /& suffici5tly long1 !y mutually de/roy ea* o!r2 s t 9 a comb9ation ( pancreat9 & peps9 ! pancreatic enzyme is lo/ & ! peps9 greatly injur$1 & :]e dia/ase is pres5t1 bo? dia/ase & peps9 7or dia/ase & pancreat97 mutually de/roy ea* o!r40 ,s9ce x has be5 demon/rat$ t peps9 & pancreat9 _c exi/ 9 "o & ! same solution = any reasonable l5g? ( "t1 x becomes app>5t t liquid prep>ations said to conta9 ^! two f]m5ts are sold "u impossible claims4 ,x is !re=e recomm5d$3 #a4 ,,t ,,! ,,c\ncil ,,on ,,ph>macy ,,& ,,*emi/ry ,,refuse ,,to ,,approve ,,liquid ,,prep>ations ,,t ,,are ,,claim$ ,,to ,,conta9 ,,bo? ,,peps9 ,,& ,,pancreat94 #b4 ,,t ,,! ,,m$ical ,,pr(ession ,,?r\gh ,,! ,,j\rnal ,,( ,,! ,,am]ican ,,m$ical ,,association ,,be ,,advis$ ,,( ,,! ,,fallacy ,,( ,,employ+ ,,su* ,,comb9ations4 #c4 ,,t ,,! ,,att5tion ,,( ,,manufactur]s ,,be ,,call$ ,,to ,,! ,,wor?lessness ,,( ,,su* ,,incompatible ,,liquid ,,prep>ations ,,( ,,peps9 ,,& ,,pancreat91 ,,& ,,t ,,!y ,,be ,,urg$ ,,to ,,cease ,,(f]+ ,,su* ,,products ,,to ,,! ,,pr(ession4 #d4 ,,t1 ,,s9ce ,,! ,,national ,,=mul>y ,,has ,,recogniz$ ,a ,,prep>ation ,,( ,,?is ,,k9d ,,"u ,,! ,,title 8,,elixir ,,dige/ivum ,,compositum10 ,,! ,,am]ican ,,ph>maceutical ,,association ,,be ,,reque/$ ,,to ,,in/ruct ,,its ,,committee ,,on ,,! ,,national ,,=mul>y ,,to ,,omit ,,?is ,,prep>ation ,,f ,,! ,,next ,,edition4 ,! recomm5dations ( ! subcommittee 7 adopt$ by ! ,c\ncil & publication ( ! report direct$4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,feb4 #b1 #aijg47 ,w4 ,a4 ,puckn]1 ,secret>y4 ,,pepto-,,mangan 7,,gude7 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! foll[+ report 0 adopt$ by ! ,c\ncil & its publication au?oriz$4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,ab\t t5 ye>s ago ! ,m4 ,j4 ,breit5ba* ,company circulat$ :at pret5d$ to be an ab/ract ( ! report ( a gov]nm5t commission = ! inve/igation ( ! anemia !n preval5t 9 ,porto ,rico4 ,! company ass]t$ t 8?is report alone w\ld suffice to e/abli% ,pepto-,mangan at once z ! =emo/ hemat9ic kn[n40 ,exam9ation ( ! (ficial report ( ! commission#fg reveal$ ! fact t ! adm9i/ration ( iron 9 hookworm anemia 0 consid]$ ( second>y importance1 & t ( ! v>i\s prep>ations ( iron1 ,blaud's pill 0 f\nd to be m effici5t ?an ,pepto-,mangan 7,gude74 ,a prote/#fh 0 made at ?is "t by ! commission aga9/ ! unw>rant$ use ( its report by ! ,breit5ba* ,company4 #fg ,! ,j\rnal1 ,sept4 #bc1 #aije1 p4 #icd4 #fh ,! ,j\rnal1 ,oct4 #g1 #aije1 p4 #ajii4 ,lat] ! ,breit5ba* ,company s5t out a report pret5d+ to prove t at ! ,infants ,hospital1 ,r&all's ,isl&1 ,new ,york ,city1 ,pepto-,mangan 7,gude7 _h be5 f\nd a mo/ sup]ior prep>ation 9 ! treatm5t ( infantile anemia4 ,inspection ( ! hospital records & daily *>ts ( ! cases disclos$#fi a rem>kable disp>ity betwe5 ! claims ( ! ,pepto-,mangan pamphlet & ! real results ( treatm5t4 ,& s "h1 also1 z well z 9 ! ,porto ,rico commission's report ! trials1 select$ by ! ,breit5ba* ,company prove ! limitations & non-sup]iority ( ,pepto-,mangan4 #fi ,! ,j\rnal1 ,april #f1 #aijg1 p4 #aaig4 ,! prec$+ false reports1 ?\gh no long] circulat$1 h nev] be5 def9itely )drawn & :ile x is n[ g5]ally conc$$ t ! good results 9 anemia are obta9$ by ! adm9i/ration ( ! v>i\s simple inorganic iron prep>ations ! ,breit5ba* ,company /ill attempts to convey ! impression t ,pepto-,mangan 7,gude7 is ( mo/ sup]ior efficacy4 ,?us ! pres5t ,pepto-,mangan circul> attempts to discr$it by obsolete & absurd or untrue /atem5ts ! v>i\s prep>ations ( iron :i* are 9 g5]al use & to c>ry ! impression t only iron & manganese1 9 ! p>ticul> =m & proportion 9 :i* !y are conta9$ 9 ,pepto-,mangan--namely1 #c p>ts ,fe to #a "p ,mn--are useful = ! treatm5t ( anemia1 *lorosis1 etc4 ,?us contr>y to g5]al conceptions1 ! impression is giv5 t ! n[ g5]ally accept$ c\rse ( *lorosis is due to ! ?ree v>ieties ( insuffici5cy ( c]ta9 blood elem5ts3 7#a7 insuffici5cy ( manganese1 7#b7 insuffici5cy ( iron1 7#c7 insuffici5cy ( iron & manganese2 & t ! adm9i/ration ( iron (t5 fails because manganese is n suppli$ to ! sy/em at ! same "t & 9 suffici5t am\nts4 ,! foll[+ /atem5t is made3 8,doctor3 8,if y h a case ( ,,anaemia1 ,,*lorosis1 or ,,am5orrhoea1 t %[s no visible sign ( improvem5t1 & y h exhau/$ ! entire li/ ( ,nauseat+ ,iron prep>ations ) little or no effect1 x is because ! blood is defici5t 9 t ess5tial oxidiz+ con/itu5t1 ,,manganese1 9 a soluble1 readily assimilable =m1 ! be/ be+ 9 comb9ation ) iron40 ,ano!r extravagant claim3 8,usually aft] tak+ x = a week its re/orative influ5ce on ! functions ( ! /oma* is felt2 appetite reappe>s1 & ! g5]al heal? is improv$ by ! increase 9 bodily w>m?1 an effect directly due to manganese40 ,! foll[+ /atem5t implies t ,pepto-,mangan is absorb$ un*ang$1 = :i* !re is no ju/ification3 8,z ! f]rug9\s & manganic +r$i5ts ( ,pepto-,mangan 7,gude7 exi/ 9 ! =m ( organic peptonates1 !y h already und]gone ! *anges necess>y to insure prompt absorption & appropriation by ! circulat+ fluid40 ,! foll[+ decl>ation implies t x repairs ! individual defective blood-cells :i* is1 ( c\rse1 also ridicul\s3 8,t ,pepto-,mangan 7,gude7 quickly & effici5tly builds up defective r$ blood cells1 & g5]ates1 or at lea/ pot5tly enc\rages ! =mation ( new ones1 & mat]ially increases _! ri*ness 9 hemoglob91 has be5 abundantly demon/rat$44440 ,! ,m4 ,j4 ,breit5ba* ,company is /ill try+ to mislead physicians2 x also aims to make use ( !m 9 its direct appeal to ! physicians' pati5ts4 ,= in/ance1 ! "n 8,pepto-,mangan 7,gude70 bl[n 9 ! bottle1 ! adv]tis+ circul> sugge/+ ,pepto-,mangan z ! treatm5t = anemia1 etc41 & ! recomm5dation to physicians t x be prescrib$ 9 8orig9al bottles0 all t5d to enc\rage ! use ( ,pepto-,mangan by ! public ) ! likelihood t x w be dep5d$ on :]e good food & fre% air are ( prime importance4 ,! attempt to exploit x directly to ! public is fur!r atte/$ by ! adv]tisem5ts ( dep>tm5t-/ore drug dep>tm5ts4 ,x is evid5t f ! =ego+ t ,pepto-,mangan 7,gude7 is 9 conflict ) ,rules #d & #f & !re=e n eligible = admission to ,new & ,non(ficial ,rem$ies4--7,f ,reports ,c\ncil ,ph>m4 & ,*em41 #aiad1 p4 #aba47 ,,liquid ,,petrolatum ,,or 8,,russian ,,m9]al ,,oil0,,ai ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,,ai ,see also foll[+ reports on ,cl9ical ,exp]i5ce ) ,liquid ,p>aff9 7,liquid ,petrolatum7 & ,angi]'s ,emulsion4 ,! foll[+ report 0 submitt$ to ! ,c\ncil by a ref]ee & its publication au?oriz$ by ! ,c\ncil4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,petroleum has be5 9 use z a m$ic9e f "t immemorial4 ,x 0 kn[n to ,h]odotus #djj ye>s be=e ,*ri/ & is m5tion$ by ,plut>*1 ,dioscorides1 ,pl9y & o!r e>ly writ]s4 ,x 0 ext5sively us$ by ! ,arabians & evid5tly play$ an important "p 9 ! practice ( m$ic9e 9 ,india1 be+ kn[n to ! ,b5galese z ,mu! ,katel4 ,! raw product 0 ! sub/ance us$ 9 e>li] times & diff]$ mu* 9 "* & composition1 z obta9$ f diff]5t s\rces4 ,z an int]nal rem$y x 0 e>ly employ$ 9 *ronic pulmon>y affections1 9 ob/9ate sk9 diseases1 9 rheumatism1 & = ! expell+ ( tapeworms4 ,x 0 ext5sively us$ = ^! sev]al purposes 9 ,france "u ! "n ( 8,oleum ,gabianum0 & 9 ,nor? ,am]ica z 8,s5eka oil40 ,! int]nal use ( ! ref9$ product may be trac$ to a pat5t grant$ to ,rob]t ,a4 ,*esebr\gh ( ,new ,york1 9 ,june1 #ahgb1 = ! manufacture ( a 8new & useful product f petroleum1 nam$ vasel9e40 ,?is "n 0 orig9ally appli$ only to a semisolid prep>ation1 b lat] a liquid product kn[n z liquid vasel9e 0 m>ket$ & = a "t exploit$ z a cure = c\ghs1 colds1 consumption & a numb] ( o!r diseases & conditions4 ,! liquid petrolatum has s9ce become kn[n "u a v>iety ( names1 propriet>y & o!rwise1 9 addition to be+ us$ z a sub/itute or an adult]ant = o!r1 m co/ly1 fats & oils4 ,"s ( ! names appli$ to ! product are3 ,adeps9e oil ,neutralol ,amilee ,olo ,atole9e ,p>aff9 ,oil ,atol9 ,p>ol9e ,bl&9e ,petralol ,crysmal9 ,petro ,deel9e ,petrolax ,glyco ,petrolia ,glycol9e ,petronol ,glymol ,petrosio ,heavy petroleum oil ,rock ,oil ,liquid ,albol5e ,russian liquid petrolatum ,liquid ,cosmol9e ,russian m9]al oil ,liquid ,fossil9e ,russian p>aff9 oil ,liquid ,geol9e ,russol ,liquid ,p>aff9 ,saxol ,liquid ,petrolatum ,t]ral9e ,liquid ,saxol9e ,t]ralbolia ,liquid ,vasel9e ,usol9e ,m9]al ,glyc]9 ,wat]-:ite m9]al oil ,m9]al ,oil ,:ite p>aff9 oil4 ,a prep>ation simil> to t (ficial 9 ! ,ph>macopeia ( ! ,unit$ ,/ates z liquid petrolatum has be5 includ$ 9 _m1 if n all1 ( ! =eign ph>macopeias1 ! (ficial titles "u :i* ?is prep>ation is recogniz$ be+ z foll[s3 ,petrolatum ,liquidum1 ,u4 ,s4 ,ph>macopeia2 ,p>aff9um ,liquidum1 ph>macopeias ( ,great ,brita91 ,g]many1 ! ,ne!rl&s1 ,japan1 ,belgium1 ,au/ria1 ,d5m>k1 ,switz]l&1 ,sw$51 ,s]via1 ,italy1 ,hung>y & ,russia2 ,oleum ,p>aff9ae1 ,spani% ,ph>macopeia2 ,vasel9um ,liquidum1 ,fr5* ,ph>macopeia1 & ,oleum ,vasel9i 7z a synonym7 ph>macopeias ( ,d5m>k & ,russia4 ,! requirem5ts ( ! sev]al ph>macopeias diff] some:at & ! specific gravity z giv5 is z foll[s3 ,u4 ,s4 ,p4 ,,viii1 #aije #j4hgj to #j4idj at #be ,ph4 ,brit4 ,,iv1 #ahie #j4hhe to #j4hij at #ae4e ,b4 ,p4 ,c4 ,,ii1 #aiaa1 usually #j4hge or l[] at #ae ,ph4 ,g]m4 ,v1 #aiaj1 at lea/ #j4hhe at #ae ,ph4 ,ross4 ,,vi1 #aiaj #j4hhj to #j4hhe at #ae ,ph4 ,hung4 ,,iii1 #aiji #j4hh to #j4hi at #ae ,ph4 ,ital4 ,,iii1 #aiji #j4hge to #j4hij at #ae ,ph4 ,fr4 ,v1 #aijh1 ab\t #j4hge at #ae ,ph4 ,s]b4 ,,ii1 #aijh1 ab\t #j4hhj at #ae ,ph4 ,svec4 ,,ix1 #aijh #j4hh to #j4ij at #ae ,ph4 ,helv4 ,,iv1 #aijg #j4hhj to #j4hhe at #ae ,ph4 ,dan4 ,,vii1 #aijg1 at lea/ #j4hhj at #ae ,ph4 ,au/r4 ,,viii1 #aijf1 at lea/ #j4hhj at #ae ,ph4 ,belg4 ,,iii1 #aijf1 n bel[ #j4hhj at #ae ,ph4 ,japon4 ,,iii1 #aijf #j4hge to #j4ide at #ae ,ph4 ,ndl4 ,,iv1 #aije1 n bel[ #j4hfj at #ae ,ph4 ,hisp4 ,,vii1 #aije #j4hdj at #ae ,= ph>maceutical purposes1 liquid petrolatum may be divid$ into two grades1 ! light] or m limpid oil1 us$ ext5sively z a vehicle = oil sprays1 & ! heavi]1 m viscid oil g5]ally recogniz$ 9 ,european ph>macopeias & us$ z an +r$i5t ( o9tm5ts & m rec5tly z a rem$y 9 ! treatm5t ( inte/9al /asis4 ,"u petrolatum liquidum ! ,u4 ,s4 ,p4 recognizes a mixture ( hydroc>bons1 *iefly ( ! me?ane s]ies1 :i* occurs z a colorless or v slightly yell[i%1 oily1 transp>5t liquid )\t odor or ta/e & hav+ a specific gravity ( ab\t #j4hgj to #j4idj at #be ,c4 ,= ! ,u4 ,s4 ,p4 ,,ix1 x is propos$ to *ange ?is requirem5t some:at s z to h x apply to a transp>5t liquid free f fluoresc5ce1 )\t odor or ta/e & hav+ a specific gravity ( f #j4hde to #j4idj at #be ,c4 ,su* a requirem5t w\ld include all ( ! available p>aff9 oils irrespective ( orig94 ,! n[ commonly available comm]cial liquid petrolatum1 us$ = ph>maceutical purposes1 is practically colorless & all ( ! bett] grades are free f odor or ta/e4 ,! specific gravity v>ies f #j4hee to #j4hie4 ,! light] oils1 hav+ a specific gravity ( f #j4hfj to #j4hgj1 are usually pref]r$ 9 ! mak+ ( oil sprays or solutions ( sub/ances to be us$ z local applications4 ,! product hav+ a specific gravity above #j4hge evid5tly conta9s a consid]able am\nt ( dissolv$ solid p>aff9 :i* sep>ates out at temp]atures at or bel[ #j ,c41 b readily dissolves aga9 at temp]atures above #aj ,c4 ,!re is consid]able diff]5ce 9 ! *emical composition ( ! p>aff9 oils obta9$ f v>i\s s\rces4 ,! ,am]ican oil consi/s l>gely ( hydroc>bons ( ! me?ane s]ies1 :ile ! ,russian oil conta9s naph!nes or hydroc>bons ( ! b5z5e s]ies1 hav+ ! empirical composition ( e?yl5e1 7,cn,h#bn7 :i* may be consid]$ z hydrog5at$ aromatic hydroc>bons1 ?\gh !y behave ) reag5ts v mu* 9 ! same way z d ! hydroc>bons ( ! me?ane s]ies4 ,m9]al oils ) a naph!ne base are be/ suit$ = mak+ :ite petrolatum1 & at ! pres5t "t ! production ( ! colorless wat]-:ite liquid petrolatum appe>s to be conf9$ l>gely or almo/ exclusively to ! crude product ( ! ,baku di/rict ( ,russia1 ?\gh x is ass]t$ t x is n[ also made f ! ,hanov] 7,g]many7 crude oil & t "s is be+ produc$ by 8crack+0 ! :ite solid p>aff94 ,x is also said t ! ,am]ican oil c be made wat] :ite b t x is n be+ s produc$ at pres5t = economic reasons2 ! yell[i% oil1 free f fluoresc5ce1 hav+ a v wide sale1 bo? z a lubricant & z a sub/itute = l>d oil & o!r ( ! m co/ly lubricat+ oils4 ,f a ph>maceutical po9t ( view x w\ld appe> important to note ! physical *>act]i/ics ( ! oil & to insi/ on abs5ce ( color1 abs5ce ( odor & ta/e1 abs5ce ( acid & ( alkali & a specific gravity 9 h>mony ) ! purposes = :i* ! oil is to be us$4 ,dur+ ! pa/ ye> or two liquid petrolatum has attract$ consid]able att5tion z a rem$y 9 ! treatm5t ( inte/9al /asis or *ronic con/ipation1 ! practice ( us+ x hav+ be5 develop$ l>gely ?r\gh its recomm5dation by ,sir ,w4 ,arbu?not ,lane & 8 associates4 ,?is use ( liquid petrolatum & ( petrolatum products g5]ally is by no means novel4 ,n4 ,a4 ,r&olph#gj ( ,philadelphia 0 among ! fir/ to sugge/ its use = ?is purpose 9 an article publi%$ 9 #ahhe4 ,r&olph also appe>s to h be5 ! fir/ to exp]im5t ) petrolatum & to det]m9e its non-absorbability f ! inte/9al tract4 ,9 an article#ga 9 #ahhd he concludes t 8pure petrolatum :ile entirely unirritat+ to ! dige/ive tract is valueless z a food/uff40 #gj ,r&olph1 ,n4 ,a43 ,!rap4 ,gaz41 ix1 #gcb4 #ga ,r&olph1 ,n4 ,a43 ,proc4 ,acad4 ,nat4 ,sc41 ,philadelphia1 #ahhd1 p4 #bha4 ,! exp]im5ts record$ by ,r&olph 7 evid5tly prompt$ by ! fact t vasel9e & a numb] ( imitation products !n on ! m>ket 7 be+ sold z sub/itutes = l>d & butt]1 & op9ions reg>d+ ! food value ( petroleum products appe> to h diff]$ v mat]ially4 ,foll[+ ! exp]im5ts ( ,r&olph1 ,rob]t ,hut*ison 9 #ahii made a s]ies ( exp]im5ts to demon/rate t petroleum1 petrolatum1 p>aff9 & relat$ products 7 absolutely unassailable by any ( ! dige/ive fluids1 despite ! 8l>ge vogue t _h ( late ye>s be5 giv5 to v>i\s petroleum emulsions1 *iefly by +5i\s & unt]rifi$ adv]tis+40 ,he came to practically ! same conclusions arriv$ at by ,r&olph fifte5 ye>s e>li] & po9t$ out t 8liquid p>aff9 9 "o s5se may be reg>d$ z an artificial inte/9al mucus & might 9 t way h "s value on c]ta9 =ms ( con/ipation40 ,william ,duffield ,rob9son#gb reports on ! use ( a p]fectly ref9$ colorless & odorless petrolatum1 suppos$ly ( ,am]ican orig94 ,he 0 able to %[ t all ( ! product pass$ un*ang$ ?r\gh ! inte/9al tract & c\ld be rega9$ f ! feces4 ,9 8 conclusions he express$ ! belief t ! effect ( ! adm9i/ration ( ^! petroleum products is f> m ?an z a simple inte/9al lubricant4 ,9 ov] fifty select$ cases 9 :i* nutrition1 dige/ion & body-weight 7 impair$1 & ! pure/ oil adm9i/]$ 9 #a- or #b-;dram doses ea* day = a p]iod ( f f\r to six mon?s1 !re 0 9 e in/ance an improvem5t ( weight1 heal? & feel+ ( well-be+4 ,! adm9i/ration ( ref9$ p>aff9 oil gave no discom=t 9 any in/ance1 ev5 9 cases 9 :i* ne>ly a p9t 0 giv5 9 a few h\rs4 #gb ,rob9son3 ,william ,duffield3 ,m$4 ,news1 #aijj1 lxxvii1 #ef4 ,william ,ew>t#gc sugge/s liquid p>aff9 z a safe ag5t = ! local treatm5t ( ! lesions 9 typhoid fev]4 ,he says 9 "p3 8,m9]al oil1 su* z petrolatum or p>aff91 is nei!r absorb$ nor dissolv$2 !re=e1 aft] all absorbable +e/ions are tak5 up by ! lacteals1 x w /ill rema9 9 ! b[el4 ,9 ?is way pure liquid p>aff9 is valuable1 precisely because x is in]t2 moreov]1 x might "s day1 p]haps1 be made ! vehicle = effective topical rem$ies40 #gc ,ew>t1 ,william3 ,brit4 ,m$4 ,j\r41 #aijb1 ii1 #aeje4 ,a4 ,d4 ,s*midt#gd quotes ,/ub5ra? z hav+ giv5 liquid p>aff9 9 ! treatm5t ( *ronic con/ipation1 & he himself gave z mu* z #bj gm4 ( liquid p>aff9 to adults )\t obs]v+ any injuri\s effect :atev]4 ,he says1 8,z a result ( ! adm9i/ration ( liquid p>aff91 ! feces are s(t5$ consid]ably & are f\nd "u ! microscope to conta9 num]\s m9ute globules ( p>aff940 ,he 01 h[ev]1 unable to recov] f ! feces ! entire quantity ( p>aff9 adm9i/]$ & believes t a c]ta9 portion ( x1 probably ! fractions ) a l[ boil+-po9t1 are absorb$ or possibly oxidiz$ 9 ! organism4 #gd ,s*midt1 ,a4 ,d43 ,mn*54 m$4 ,w*ns*r41 #aije1 lii1 #aigj4 ,maurice ,vejux ,tyrode#ge also ref]s to ! use ( liquid petroleum 9 ! treatm5t ( con/ipation4 #ge ,tyrode1 ,maurice ,vejux3 ,bo/on ,m$4 & ,surg4 ,j\r41 #aiaj1 clxii1 #fgc4 ,sir ,w4 ,arbu?not ,lane 9 8 recomm5dations ( liquid petrolatum calls x an ideal rem$y = /asis1 b cautions aga9/ ! use ( ! light] oil z ext5sively prescrib$ 9 ?is c\ntry z a vehicle = sprays 9 nose & ?roat "w4 ,p>aff9 oil is n absorb$ f ! alim5t>y tract & s f> z kn[n ex]ts no delet]i\s influ5ce4 ,x is usually giv5 9 quantities ( f #aj to #bj c4c4 half an h\r or an h\r be=e meals or 9 l>g] doses1 f #cj to #ej c4c41 at "o "t on retir+4 ,f available evid5ce x appe>s t comp>atively huge doses may be adm9i/]$ )\t ! production ( any unt[>d results4 ,accord+ to _m obs]v]s1 liquid p>aff9 %\ld n be giv5 ) or aft] meals because ( ! inhibit+ influ5ce t x may h on ! dige/ion ( food4 ,x is n soluble 9 wat] or ! ord9>y solv5ts & !re=e _c be dilut$4 ,! d5s] oils are pref]ably slightly w>m$ or drunk ) w>m wat] s z to obviate ! disagreeable slimy s5sation t p]si/s :5 tak5 cold4 ,volatile oils may be us$ 9 mod]ate am\nts to give a di/9ctive ta/e to ! o!rwise r insipidly ta/eless p>aff9 oil4 ,among ! m desirable oils to be us$ = ?is purpose w\ld be oil ( pepp]m9t1 oil ( c9namon1 oil ( betula or me?yl salicylate & oil ( cloves4 ,f #b to #aj drops ( any ( ^! oils c be add$ to a p9t ( ! oil4 ,:5 l>g] doses ( ! oil are to be giv5 at "o "t1 x w\ld1 ( c\rse1 be advisable to use a comp>atively small] quantity ( ! volatile oil z a flavor4#gf #gf ,9 addition to ! articles ref]r$ to 9 ! prec$+ footnotes1 ! foll[+ are ( int]e/ 9 connection ) ?is subject3 ,editorial1 ,!rap4 ,gaz41 #ahhe1 ix1 #cec4 ,junk]1 ,f4 ,a43 ,m$4 ,record1 ,london1 #ahhe1 xiii1 #ejf4 ,editorial1 ,m$4 ,news1 #ahhf1 xlviii1 #aje4 ,dunb>3 ,deuts*4 m$4 ,w*ns*r41 #ahif1 xxii1 #cc4 ,/ub5ra?1 ,franz ,casimir3 ,mn*54 m$4 ,w*ns*r41 #ahig1 xliv1 #fci4 ,london ,lett]1 ,m$4 ,news1 #ahii1 lxxiv1 #ejd4 ,hut*ison1 ,rob]t3 ,brit4 ,m$4 ,j\r41 #ahii1 i1 #gbd4 ,s*les+]1 ,e4 ,g43 ,bo/on ,m$4 & ,surg4 ,j\r41 #aiac1 clxix1 #ad4 ,lane1 ,w4 ,arbu?not3 ,brit4 ,m$4 ,j\r41 #aiac1 ii1 #aabf2 ,proc4 ,roy4 ,soc4 ,m$41 #aiac1 vi1 #di2 ,surg4 ,gynec4 & ,ob/41 #aiac1 xvi1 ,no4 #f4 ,jordan1 ,alfr$ ,c43 ,practition]1 ,london1 ,febru>y1 #aiac4 ,*rysospa!s1 ,j4 ,g43 ,z5tralbl4 f4 ,*ir41 #aiac1 ,no4 #de2 ab/r41 ,! ,j\rnal ,a4 ,m4 ,a41 ,dec4 #ac1 #aiac1 p4 #bbja4 ,f ! =ego+ x w\ld appe> t ap>t f ! ,ph>macopeia ( ! ,unit$ ,/ates1 practically all o!r kn[n ph>macopeias describe a wat]-:ite m9]al oil "u ! title 8,p>aff9um ,liquidum0 or 8,liquid ,p>aff90 z a colorless1 odorless1 ta/eless1 non-fluoresc5t1 oily liquid1 free f acids1 alkalies & organic impurities4 ,z expla9$ be=e1 ! specific gravity ( ! prep>ation z recogniz$ 9 o!r c\ntries & z (f]$ on ! ,am]ican m>ket at ! pres5t "t v>ies consid]ably1 & !re appe>s to be "s diff]5ce ( op9ion z to ! exact nature ( ! product t is pref]able = use = diff]5t purposes4 ,?is matt] requires fur!r inve/igation4 ,s9ce ! def9ition ( liquid petrolatum 9 ! ,u4 ,s4 ,ph>macopeia p]mits ! use ( fluoresc5t products ( widely v>y+ specific gravities1 x is recomm5d$ t physicians :o desire ! wat]-:ite non-fluoresc5t 7,russian7 m9]al oil %\ld use ! t]m 8,petrolatum ,liquidum1 ,grave10 or 8,p>aff9um ,liquidum1 ,b4 ,p410 if ! heavy product recomm5d$ by ,lane is desir$1 & 8,petrolatum ,liquidum1 ,leve0 if ! light v>ieties are requir$4 ,x is fur!r recomm5d$ t "u ! =ego+ names1 manufactur]s & ph>maci/s be reque/$ to disp5se ! products1 9 accordance ) ! foll[+ descriptions3 ,petrolatum ,liquidum1 ,grave4--,heavy 7,russian7 ,liquid ,petrolatum4--,p>aff9um ,liquidum1 ,b4 ,p41 liquid p>aff94--,a transp>5t1 colorless1 ta/eless1 non-fluoresc5t1 oily liquid1 odorless :5 cold b giv+ (f a fa9t petroleum odor on heat+4 ,?is prep>ation %\ld correspond to ! requirem5ts ( ! ,briti% ,ph>macopeia = liquid p>aff9 & h a specific gravity ( ab\t #j4hhe to #j4hij at #ae ,c4 ,x is insoluble 9 wat] or alcohol b soluble 9 boil+ absolute alcohol & readily soluble 9 e!r1 *lor(orm1 c>bon disulphid1 petroleum b5z91 b5z5e & fix$ & volatile oils4 ,x s]ves z a solv5t = volatile oils & relat$ sub/ances l camphor1 m5?ol & ?ymol4 ,?is is ! type ( prep>ation us$ by ,sir ,w4 ,arbu?not ,lane1 & 8 associates = int]nal adm9i/ration4 ,x is also us$ z a basis = o9tm5ts & salves & z a local application to w\nds1 ulc]s & 9 c]ta9 =ms ( sk9 diseases 9 :i* a simple protective is desir$4 ,petrolatum ,liquidum1 ,leve4--,light 7,russian7 ,liquid ,petrolatum4--,a transp>5t1 colorless1 ta/eless1 non-fluoresc5t1 oily liquid1 odorless :5 cold1 b giv+ (f a fa9t petroleum odor on heat+4 ,9 o!r respects ?is prep>ation %\ld correspond to ! ph>macopeial te/s = liquid petrolatum & h a specific gravity ( ab\t #j4hfj to #j4hge at #ae ,c4 ,l ! heavy v>iety ( liquid petrolatum1 x is insoluble 9 wat] & alcohol1 b soluble 9 boil+ absolute alcohol & rapidly soluble 9 e!r1 *lor(orm1 c>bon disulphid1 petroleum b5z91 b5z5e & fix$ & volatile oils4 ,x s]ves z a solv5t = volatile oils & relat$ sub/ances l camphor1 m5?ol & ?ymol4 ,?is is a type ( prep>ation ext5sively us$ z a vehicle = ! oily sprays 9 nose & ?roat "w4 ,x is also be+ us$ z "o ( ! con/itu5ts 9 ! n[ popul> p>aff9 oil cold cream & has be5 us$ to "s ext5t = int]nal adm9i/ration 9 ! treatm5t ( *ronic /asis4 ,be+ m limpid ?an ! prep>ation pref]r$ by ,lane1 x is m readily tak51 ?\gh great] c>e mu/ be ex]cis$ 9 secur+ a sample devoid ( ! light] fractions ( petroleum di/illates4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,may #cj1 #aiad47 ,,cl9ical ,,exp]i5ce ,,) ,,liquid ,,p>aff9 7,,liquid ,,petrolatum7,,aj ,a ,comp>ative ,inve/igation ,made ,"u ! ,auspices ( ! ,c\ncil on ,ph>macy & ,*emi/ry,,ak ,w4 ,a4 ,ba/$o1 ,m4,d41 ,new ,york ,,aj ,see also prec$+ report on ,liquid ,petrolatum or 8,russian ,m9]al ,oil0 & foll[+ report on ,angi]'s ,emulsion4 ,,ak ,?is inve/igation 0 made "u ! auspices ( ! ,committee on ,!rapeutic ,rese>* ( ! ,c\ncil on ,ph>macy & ,*emi/ry ( ! ,am]ican ,m$ical ,association4 ,at ! reque/ ( ! committee1 ,dr4 ,w4 ,a4 ,ba/$o has prep>$ ?is critical review ( ! reports made by ^? :o collaborat$ 9 ?is inve/igation4 ,dur+ ! pa/ ?ree or f\r ye>s1 8m9]al oil0 has come into ext5sive use 9 ! treatm5t ( con/ipation4 ,prep>ations ( ! ,russian & ! ,am]ican oil1 bo? heavy & light1 h appe>$ on ! m>ket1 b !re h be5 no satisfactory data on :i* to base a selection ( oil = use4 ,!re=e1 9 ord] to obta9 reliable cl9ical in=mation conc]n+ ! relative effici5cy ( ! diff]5t oils1 ! ,!rapeutic ,rese>* ,committee ( ! ,c\ncil on ,ph>macy & ,*emi/ry ( ! ,am]ican ,m$ical ,association submitt$ samples ( ! oils to v>i\s cl9icians = te/+4 ,! foll[+ is a synopsis ( ! inve/igation1 :i* ,i h prep>$ at ! reque/ ( ! committee4 ,! collaborators 7 advis$ t specim5s ( ! be/ obta9able light ,russian liquid petrolatum1 heavy ,russian liquid petrolatum & an ,am]ican br& ( liquid petrolatum w\ld be s5t out1 b t1 to avoid bias1 ^! specim5s w\ld be di/+ui%$ only by numb]s or lett]s4 ,! oils s5t out 7 7#a7 a light 8,russian0 liquid petrolatum hav+ a specific gravity ( #j4hfj at #bj ,c41 7#b7 a heavy 8,russian0 liquid petrolatum hav+ a specific gravity ( #j4hhe at #bj ,c41 & 7#c7 an 8,am]ican0 liquid petrolatum hav+ a specific gravity ( #j4heg at #bj ,c4 & be+ m>k$ly fluoresc5t4 ,! collaborators 7 advis$ t ! reports %\ld furni% in=mation z to size & frequ5cy ( dose1 ! agreeabl5ess to ! ta/e1 ! effect on ! /oma*1 ! numb] & "* ( ! /ools1 ! degree ( admixture ( ! oil ) ! o!r +r$i5ts ( ! /ool1 ! degree ( leakage ( oil ab\t ! anus1 & ! ne$ ( o!r ca?>tic measures4 ,reports h be5 receiv$ f ,drs4 ,l4 ,f4 ,b>k]1 ,w4 ,a4 ,ba/$o1 ,j4 ,b4 ,*ampion1 ,h5ry ,a4 ,*ri/ian ) ,c4 ,k4 ,dr9k] & ,f4 ,a4 ,hat*1 ,alfr$ ,/5gel & ,r4 ,l4 ,wilbur4 ,,conclusions ,! conclusions to be drawn f ! cl9ical reports are3 ,dosage4--,half an ounce to #c ounces a day4 ,9 ! same pati5t1 ! same am\nt ( ea* ( ! oils 0 requir$4 ,frequ5cy ( ,dose4--,! same am\nt daily seem$ z effici5t :5 giv5 9 "o dose z :5 giv5 9 divid$ doses two or ?ree times a day4 ,agreeabl5ess to ! ,ta/e4--,!re is a diff]5ce ( op9ion 9 ?is reg>d4 ,two reports favor$ ! heavy ,russian oil4 ,"o report favor$ ! light ,russian petrolatum4 ,b ! ta/e ( any ( ! samples 0 s slight z to be a negligible quantity aft] ! pati5t _h tak5 ! rem$y = two or ?ree days4 ,/oma* ,effects4--,9 ab\t #bj p] c5t4 ( ! pati5ts1 ! oil produc$ a slight degree ( nausea or t5d$ to repeat4 ,?is is mo/ likely 9 pati5ts :o h ga/ric /agnation ) ret>d$ empty+ ( ! /oma*4 ,all ! oils act$ ! same 9 ?is reg>d4 ,vomit+ 0 report$ 9 two cases4 ,numb] ( ,/ools4--,to produce "o or two copi\s /ools a day ! dose requir$ v>i$ consid]ably1 b !re 0 no diff]5ce not$ on acc\nt ( diff]5ce 9 ! specific gravity or "* ( ! oils4 ,"* ( ,/ools4--,! /ools 7 s(t1 usually =m$1 sometimes mu%y1 obvi\sly greasy4 ,!y _h a peculi> odor describ$ z s\r4 ,_! consi/5cy v>i$ ) ! dose1 b 0 ! same = ! diff]5t k9ds ( oil4 ,admixture ( ,oil ) ,o!r ,+r$i5ts ( ,/ool4--,g5]ally well mix$1 b f "t to "t a pati5t w\ld h a /ool ( free oil4 ,?is occurr$ ) all v>ieties ( oil4 7,x necessitat$ r$uction ( ! dose1 & if !n ! b[els 7 n active en\gh1 ! adm9i/ration 9 addition ( casc>a1 alo91 etc47 ,leakage ,ab\t ! ,anus4--,a disagreeable feature compla9$ ( by _m is t :5 !y take en\gh ( ! oil to move ! b[els1 !re is suffici5t leakage f ! anus to keep ! neighbor+ sk9 cont9ually 9 a greasy condition1 & sometimes to /a9 ! clo!s4 ,t !re is any diff]5ce 9 ?is reg>d betwe5 ! oils has n be5 det]m9$4 ,9 ! reports1 "o cl9ician not$ no diff]5ces t 7 n negligible4 ,ano!r 0 slightly 9 favor ( ,no4 #b 7heavy ,russian7 z reg>ds ta/e4 ,a ?ird report] did n make comp>ative te/s4 ,a f\r? is slightly 9 favor ( 8,b0 7heavy ,russian7 z reg>ds ta/e & g5]al suitability4 ,all ( ! f9d+s ( ?is inve/igation are bas$ on hospital cases4 ,a fif? report] favor$ ,no4 #a 7light ,russian petrolatum74 ,he consid]$ x ! mo/ prompt 9 its effect1 ! mo/ uni=m 9 results1 & ! mo/ prone to give a satisfactory admixture ( ! oil ) ! o!r mat]ials4 ,! diff]5ce1 h[ev]1 f ! o!r oils 0 n m>k$4 ,ano!r report] not$ no special diff]5ces4 ,,summ>y ,! results ( ?is cl9ical inve/igation appe> to w>rant ! conclusion t s f> z !rapeutic results are conc]n$ ! diff]5ces 9 ! action ( ! ?ree v>ieties ( liquid petrolatum1 namely1 light ,russian liquid petrolatum1 heavy ,russian liquid petrolatum & ,am]ican liquid petrolatum1 are too slight to be ( importance4 ,h5ce ! *oice betwe5 ! light] & ! heavi] oils1 & betwe5 ! ,russian & ! ,am]ican is an op5 "o1 to be det]m9$ n by !rapeutic diff]5ces1 b by palatability1 dep5d5t on ! degree to :i* ! ref9em5t ( ! oil is c>ri$ out4 ,! ,u4 ,s4 ,ph>macopeia1 ! revision ( :i* is n[ ne>+ completion1 no d\bt w furni% /&>ds :i* w insure a suitable product4 ,f ! f9d+s ( ! =ego+ report x w\ld appe> t a satisfactory /&>d might p]mit ! use ( ei!r ,russian or ,am]ican oil1 if suitably ref9$ s z to be z ne>ly z possible devoid ( odor & ta/e4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,m>* #f1 #aiae47 ,,angi]',s ,,emulsion,,al ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,,al ,see also prec$+ reports on ,liquid ,petrolatum or 8,russian ,m9]al ,oil0 & ,cl9ical ,exp]i5ce ) ,liquid ,p>aff9 7,liquid ,petrolatum74 ,angi]'s ,emulsion is ess5tially a petroleum product4 ,:5 x 0 fir/ put on ! m>ket comm]cial int]e/s _h be5 fo/]+ ! idea t petroleum products _h food-value1 & ! manufactur]s ( ,angi]'s ,emulsion1 mak+ use ( ! idea1 adv]tis$ x z a 8food-m$ic9e0 & an 8ideal sub/itute = cod-liv] oil40 ,! impression ?us creat$ has be5 kept alive ?r\gh p]si/5t adv]tis+ 9 spite ( sci5tific pro( to ! contr>y4 ,to-day _m :o "k t petroleum products h no food-value are /ill likely unconsci\sly to class ,angi]'s ,emulsion among nutri5ts4 ,al?\gh ! manufactur]s n[ adv]tise ?is product z 8purely me*anical 9 its action10 !y yet %[ a disposition to pr(it by ! old misappreh5sion1 s9ce1 s f> f expressly disav[+ ! old claims z errone\s1 !y m+le ) ! new ones vague claims ( 8tonic & recon/ructive m]its0 app>5tly design$ to su/a91 9 ^? :o d n take "t to consid] ! evid5ce c>efully1 ! old fai? 9 ! claim$ nutritive qualities ( ! prep>ation4 ,:ile ! ,c\ncil judges a prep>ation by ! claims made = x at pres5t1 & n by any pa/ mis/atem5ts :5 ^! h be5 ?or\ghly correct$1 ! pa/ adv]tis+ ( ,angi]'s ,emulsion s in/ructively illum9ates ! sci5tific wor?lessness ( propriet>y !rapeutic claims 9 g5]al1 & ! :ole c\rse ( its hi/ory is s typical t ! ref]ee has ?\ght x well to review ! subject briefly4 ,! ,c\ncil has au?oriz$ ! publication ( ! foll[+ report4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,angi]'s ,petroleum ,emulsion 0 br\ght out 9 #ahha--t is to say1 be=e ! food-value ( petroleum products _h be5 exp]im5tally disprov$4 ,its adv]tis+ hi/ory well illu/rates ! we$-l vitality ( a f9ancially pr(itable !rapeutic fallacy4 ,! %ift+ claims made = ?is prep>ation are su* good examples ( ! g5]ally unreliable !rapeutic pret5sions ( propriet>y m$ic9es--:e!r ( ! 8pat5t m$ic9e0 or ( ! 8e?ical propriet>y0 type--t x has be5 deem$ advisable to pres5t a brief review ( ! conflict+ claims made = x at v>i\s times4 ,a ,,petroleum ,,product ,angi]'s ,emulsion is describ$ by ! manufactur]s z conta9+1 9 addition to 8our specially purifi$ ,petroleum10 8! comb9$ hypophosphites ( lime & soda1 *emically pure glyc]9e1 & ! necess>y emulsify+ ag5ts40 ,s f> z ! hypophosphites are conc]n$1 x is probably unnecess>y to rem>k t ! late/ rese>*es br+ to light no evid5ce t !y influ5ce metabolism 9 ! slighte/ degree4 ,! ,angi] ,*emical ,company app>5tly accepts ?is view1 = 9 its adv]tis+ /ress is laid exclusively on ! m]its ( ! emulsion z a petroleum product4 ,x is !re=e prop] to consid] x f ?is po9t ( view4 ,! hi/ory ( ! int]nal use ( liquid petrolatum 0 sket*$ 9 a rec5t ,c\ncil report4#gg ,z m5tion$ at t "t1 a numb] ( petroleum products 7 put on ! m>ket "s ?irty ye>s ago z sub/itutes = l>d & butt]4 ,contempor>y op9ions reg>d+ ! food value ( su* products diff]$ widely4 #gg ,liquid ,petrolatum or 8,russian ,m9]al ,oil10 p4 #afa4 ,!re nev] 0 any sci5tific evid5ce to support ! view t petroleum & its d]ivatives are assimilable by ! animal organism4 ,9 fact1 s f> z we c le>n1 !re 0 no sci5tific inve/igation ( ! problem until ,r&olph's exp]im5ts 9 #ahhd4 ,^! 7 probably ! fir/ to demon/rate ! non-absorbability ( petroleum & its valuelessness z a food/uff4 ,9 #ahii ,rob]t ,hut*ison conclusively demon/rat$ by exp]im5t t petrolatum1 p>aff9 & relat$ products 7 absolutely unassailable by any ( ! dige/ive fluids1 & !re=e c\ld n possibly h any food value4 ,v>i\s inve/igators lat] confirm$ ^! f9d+s4 ,,fir/ ,,adv]tis$ ,,z ,a 8,,food-,,m$ic9e0 ,let u n[ take up ! adv]tis+ hi/ory ( ?is no/rum4 ,9 #ahie x 0 sold "u ^! claims3 8444 a #8,food-,m$ic9e' t is f> m ?an a sub/itute = cod-liv] oil02 8444 a ,food-,m$ic9e t is readily assimilat$ & helps to dige/ o!r foods40 ,9 #ahig x 0 an3 8,ideal ,sub/itute = ,cod ,liv] ,oil40 ,9 #ahii x3 8444 cons]ves heat & en]gy by furni%+ m mat]ial = oxidation40 ,9 #aijb x3 8444 supplants tissue wa/e by tissue recon/ruction40 ,! promot]s ( ,angi]'s ,emulsion ?us = "s "t ignor$ ! /atus def9itely assign$ to petroleum products by ! exp]im5ts ( ,r&olph1 ,hut*ison & o!rs4 ,?is 0 only natural4 ,if petrolatum 0 absolutely in]t 9 ! alim5t>y canal 7& ?is 0 n[ prov$ beyond controv]sy7 !n an emulsion prep>$ f x mo/ c]ta9ly 0 n a 8food-m$ic9e10 c\ld n 8supplant tissue wa/e10 or 8cons]ve heat & en]gy40 ,all ! cr$it :i* previ\s 8unt]rifi$ & +5i\s adv]tis+0 7to quote ,hut*ison7 _h accumulat$ = ,angi]'s ,emulsion 0 b\nd up ) ! view t petroleum products 7 food/uffs4 ,,lat] ,,adv]tis$ ,,z ,,non-,,absorbable ,! non-absorbability ( liquid petrolatum1 h[ev]1 sugge/$ to ,rob9son1 ,s*midt1 ,lane & o!rs1 a new !rapeutic use = x 9 ! treatm5t ( *ronic con/ipation4 ,?is me?od has rapidly ga9$ popul>ity & x is n surpris+1 !re=e1 t ! promot]s ( ,angi]'s ,emulsion *ang$ _! claims accord+ly1 & n[ began to base _! adv]tis+ *iefly on ! prov$ prop]ties ( petrolatum4 ,9 #aiaj ! emulsion 0 adv]tis$ = ! treatm5t ( *ronic di>rhea on ^! gr\nds3 8444 giv5 by ! m\?1 x passes to ! l[]mo/ portions ( ! inte/9es )\t *ang+ its id5tity2 h5ce x ex]ts antiseptic1 soo?+ & demulc5t prop]ties ^u e in* ( ! inte/9al tract1 f ! duod5um to ! rectum40 ,! old claims1 h[ev]1 7 n disc>d$ altoge!r1 = 9 #aiaa ! prep>ation 0 recomm5d$ = *ildr5's diseases z3 8444 an aid to appetite & dige/ion & a spl5did tonic & build]40 ,be=e long ! attempt 0 made to weave toge!r ! claims bas$ on oppos$ & mutually incompatible prop]ties4 ,9 #aiab we f9d ,angi]'s ,emulsion recomm5d$ because x3 8444 corrects dige/ive di/urbance & promotes normal action ( ! b[els4 ,at ! same "t x has a mo/ invigorat+ tonic influ5ce ^u ! g5]al heal?40 ,9 #aiad m$ical m5 are advis$ ?r\gh ! adv]tis+ pages ( ! ,briti% ,m$ical ,j\rnal ( !3 8444 tonic & recon/ructive m]its ( ,angi]'s ,emulsion40 ,a pamphlet on 8,con/ipation10 :i* is 8,pres5t$ to ,physicians ) ,complim5ts ( ! ,angi] ,*emical ,company0 7copyright1 #aiac2 /ill di/ribut$ 9 #aiad7 in=ms physicians t ,angi]'s ,emulsion is3 8444 purely me*anical 9 its action40 ,not)/&+ ?is1 we are told lat] on 9 ! same pamphlet t x3 8444 facilitates1 ha/5s & assi/s ! processes ( dige/ion & assimilation40 444 8is a mo/ efficaci\s rem$y 9 ,pulmon>y ,tub]culosis because x n only ma9ta9s normal nutrition1 b also ex]ts a well-def9$ specific palliative influ5ce ^u ! c\gh & o!r symptoms ( ! disease40 ,evid5tly ! adv]tisem5t is writt5 9 ! hope t 9 "o p>agraph a claim bas$ on ! prov$ prop]ties ( petroleum products may be sub/antiat$1 :ile 9 ano!r a totally diff]5t & inconsi/5t claim may be glibly ins9uat$ 9 vague phrases design$ to lull ?\ght & ?us p]=m ! rem>kable feat ( secur+ cr$5ce = two contradictory /atem5ts4 ,,unw>rant$ ,,& ,,mislead+ ,,claims ,fur!r evid5ce t ,angi]'s ,emulsion is at pres5t exploit$ bo? to ! m$ical pr(ession & to ! public "u claims t are unw>rant$ & mislead+1 if n z palpably untrue z ! claims made 9 ! pa/1 is f\nd on ! wrapp] ( a trade package pur*as$ 9 #aiad & 9 ! circul> accompany+ x4 ,note ! foll[+3 8,indicat$ 9 ,diseases ( ! ,?roat & ,lungs & ( ! ,dige/ive ,app>atus4 ,useful 9 ,g5]al ,debility & ,wa/+ ,diseases1 ,especially :5 due to ,faulty ,nutrition4 ,! antiseptic prop]ties ( ! ,emulsion p>ticul>ly adapt x to ! treatm5t ( diseases ( septic or bact]ial orig940 8,angi]'s ,petroleum ,emulsion is indicat$ 9 affections ( ! ?roat1 lungs & inte/9al tract--bo? subacute & *ronic4 ,9 diseases ( ! dige/ive app>atus due to cat>rhal1 ulc]ative or tub]cul\s conditions1 its peculi> soo?+1 heal+ & aseptic prop]ties make its use especially b5eficial4 ,wa/+ diseases1 p>ticul>ly :5 due to faulty nutrition1 are greatly b5efit$ by its use1 "o ( ! mo/ noticeable effects be+ a prompt & decid$ increase 9 weight40 ,x is1 ( c\rse1 unnecess>y to po9t out t1 s9ce petroleum is non-absorbable1 ,angi]'s ,emulsion conta9s no +r$i5t capable ( affect+ ! respiratory muc\s membrane except by local application1 = :i*1 inde$1 ?is prep>ation is evid5tly n int5d$4 ,,composition ,,& ,,=mulas ,accord+ to a circul> :i* 0 conta9$ 9 a trade package rec5tly pur*as$ 8,ea* fluid\nce ( ,angi]'s ,petroleum ,emulsion ) hypophosphites conta9s3 #cc-a_/c p] c5t4 ( our specially purifi$ ,petroleum2 #i gra9s ( ! comb9$ hypophosphites ( lime & soda1 *emically pure glyc]9 & ! necess>y emulsify+ ag5ts40 ,z reg>ds ! nature ( ! product ref]r$ to "u ! indef9ite t]m 8petroleum0 ! circul> /ates t ,angi]'s ,emulsion is3 8444 prep>$ ) ref9$ petroleum specially purifi$ = ! purpose4 ,by a process peculi>ly our own ! crude petroleum1 obta9$ f special wells is s purifi$ t all ta/e & odor & all objectionable & irritat+ prop]ties are remov$1 :ile ! full m$ic9al value ( ! oil is reta9$44440 ,! composition assign$ to ,angi]'s ,emulsion 9 an adv]tis+ pamphlet 8,! ,petroleum ,idea10 issu$ 9 #aijg diff]s 9 t x is said to conta9 8specially purifi$ crude petroleum0 & t ea* fluid\nce is said to conta9 #b4hd gra9s ( b5zoate ( sodium4 ,:ile ^! quotations convey ! impression t c]ta9 m$ic9al con/itu5ts ( ! 8specially purifi$0 product obta9$ f 8special wells0 are 8reta9$10 a pamphlet recomm5d+ ! use ( ,angi]'s ,emulsion = ! treatm5t ( con/ipation assures u t x produces ! 8me*anical effects ( ! pure/ petroleum0 & t x is 8purely me*anical 9 its action40#gh #gh ,z is ! cu/om 9 ! exploitation ( propriet>y m$ic9es1 ! prep>ation :i* is ! firm's ma9 output--! lead]--is made to d duty z an adv]tis+ m$ium = auxili>y prep>ations4 ,?us ! ,angi] ,emulsion booklet advises ! use ( ,angi]'s ,?roat ,tablets4 ,^! tablets are alleg$ to be compos$ ess5tially ( elm b>k & petroleum1 are claim$ to 8promote appetite & aid dige/ion10 & x is /at$ t 8_! heal+ action on all muc\s surfaces makes !m decid$ly b5eficial1 n only to ! pulmon>y tract b on ! dige/ive areas z well40 ,angi]'s ,?roat ,tablets 7 exam9$ 9 ! ,association's ,laboratory to det]m9e ! am\nt & k9d ( petroleum pres5t 9 ! tablets4 ,extraction ( ! tablets ) e!r yield$ a petroleum product :i* resembl$ 9 e way ! product obta9$ f ! emulsion4 ,slightly less ?an #ab p] c5t4 ( ! tablet 0 compos$ ( ! petroleum oil4 ,! "p insoluble 9 e!r appe>$ to consi/ ess5tially ( elm b>k1 ) gum & sug>4 ,,laboratory ,,report ,! /atem5ts reg>d+ ! id5tity ( ! 8petroleum0 are s unsatisfactory & contradictory 79 "o place 8ref9$ petroleum specially purifi$ = ! purpose10 9 ano!r 8specially purifi$ crude petroleum0--9 "o place 8m$ic9al0 & 9 ano!r 8purely me*anical 9 its action07 t ! help ( ! ,*emical ,laboratory ( ! ,association 0 invok$ to e/abli% ! "* ( ! petroleum product & to det]m9e ! pres5ce or abs5ce ( sodium b5zoate1 at "o "t decl>$ by ! manufactur]s to be pres5t b lat] omitt$ f ! =mula4 ,! ,association's *emi/s report$3 8,f a specim5 ( ,angi]'s ,emulsion rec5tly pur*as$ !re 0 sep>at$ by ! cu/om>y me?ods ( analysis1 a yell[ fluoresc5t1 unsaponifiable1 semi-solid residue :i* has all ! prop]ties ( ord9>y yell[ petrolatum ( a consi/5ce some:at s(t] ?an ! product describ$ 9 ! ,ph>macopeia4 ,x 0 mu* m d5se ?an ! colorless1 non-fluoresc5t liquid petrolatum n[ 9 vogue z a laxative4 ,! prep>ation conta9$ b5zoate1 bo? 9 ! =m ( free b5zoic acid & also 9 ! =m ( a wat]-soluble salt probably sodium b5zoate40 ,! petroleum product conta9$ 9 ! emulsion 0 ?us %[n to be int]m$iate betwe5 ! ord9>y 7solid7 & ! liquid petrolatum4 ,x also appe>s t a b5zoate is /ill pres5t1 ?\gh no long] m5tion$ 9 ! =mula4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,sept4 #ab1 #aiad47 ,,phecolates1 ,,phecolax1 ,,phecozymes ,,& ,,phecotones ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,phecolates1 ,phecolax1 ,phecozymes & ,phecotones 7 submitt$ by ,f4 ,waldo ,:itney1 ,new ,york1 ) 8lit]ature0 indicat+ t !y are design$ to =m p>ts ( a sy/em ( treatm5t f\nd$ on ! !ory ( autotoxemia1 :i* !y are suppos$ to prev5t by _! action on ! functions ( ! inte/9al canal4 ,! diff]5t prep>ations consi/ 9 ! ma9 ( mixtures ( well-kn[n rem$ies4 ,! basic prep>ation is ,phecolates1 :i* conta9s bile salts 9 comb9ation ) ph5yl salicylates & b5zo-naph?ol 9 ab\t "o-eigh? ! regul> doses & h5ce n likely to be ( any real s]vice4 ,s9ce ! proportions ( ^! +r$i5ts ought to be regulat$ by ! physician accord+ to ! ne$s ( ! individual pati5t1 !y %\ld n be comb9$ 9 fix$ proportions4 ,! "n is n s fram$ z to indicate ! pr9cipal +r$i5ts4 ,phecolax conta9s1 9 addition to ! +r$i5ts ( ,phecolates1 ph5olph?ale9 & casc>91 ( ea* "o-half gra94 ,phecozyme is made m complex ?an ,phecolax by ! introduction ( additional ph5yl salicylate & ( pancreat94 ,phecotone conta9s t5 +r$i5ts4 ,extravagant claims su* z ! foll[+ are made3 8,our ,heal? is gov]n$ by our b[els2 ,our b[els are gov]n$ by our n]ves2 ,our n]ves are gov]n$ by our dige/ion2 our dige/ion is gov]n$ by ,phecolates40 ,! ,c\ncil vot$ to refuse recognition to ,phecolates1 ,phecolax1 ,phecozymes & ,phecotones z unsci5tific articles ) objectionable names4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #ba1 #aiad47 ,,ph5ol ,,sodique ,report ( ,exam9ation by ,c\ncil on ,ph>macy & ,*emi/ry & ,comm5ts ,an exam9ation ( ?is article by a subcommittee ( ! ,c\ncil on ,ph>macy & ,*emi/ry reveal$ unscrupul\s claims :i* are a positive m5ace to public heal?4 ,9 view ( ?is ! ,c\ncil has direct$ ! publication ( ! foll[+ comm5ts4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,,comm5ts ,ph5ol ,sodique 0 n submitt$ to ! ,c\ncil by ! manufactur]s1 b 0 tak5 up because x is adv]tis$ to bo? physicians & ! public4 ,"s adv]tisem5ts /ate3 8,ph5ol ,sodique 0 ! /&>d antiseptic ?irty ye>s ago4 ,x's ! same today40 ,if ?is 7 true1 x w\ld be high "t to call a halt2 = ! unscrupul\s claims made = ?is no/rum1 & ! effront]y ) :i* !y are pu%$1 are only rival$ by ^? ( ! mo/ %ameless 8pat5t m$ic9es40 ,! firm ( ,hance ,bros4 ,:ite poses z a reputable ph>maceutical manufactur+ h\se1 b h[ x c reconcile ?is position ) _! me?od ( exploit+ ?is product passes all und]/&+4 ,9 ! orig9al package ( ,ph5ol ,sodique 7! late/ 0 pur*as$ on ,june #bj1 #aijg71 !re are little booklets & a fold] describ+ ! m>vel\s prop]ties ( ! no/rum4 ,! booklets d n ref] to ,ph5ol ,sodique1 b !y are v in/ructive4 ,!y are entitl$3 8,dyspepsia10 8,worm ,news10 & 8,cat>rh10 adv]tis+ 8,dyspepsia ,/op0--"s =m ( dyspepsia tablets1 a rem$y = r\nd worms1 & 8,cat>rh ,/op10 app>5tly "s mild antiseptic tablets4 ,^! booklets are address$ frankly to ! laity1 al?\gh rec\rse to a physician is1 g5]\sly1 advis$ if ! pati5t does n respond to treatm5t6 ,! folly ( prescrib+ 8orig9al packages0 :i* conta9 popul> lit]ature has be5 s (t5 emphasiz$ t fur!r comm5t seems sup]flu\s4 ,! foll[+ f 8,cat>rh10 h[ev]1 ?r[s an int]e/+ sidelight on ! sci5tific /atus ( ,hance ,bros4 ,:ite3 ---------------------------------------- ---------------- 8,cat>rh is due to a m9ute insect 9 ! inn] l9+ membrane ( ! nose4 ,?is insect multiplies rapidly1 &1 unless *eck$1 & de/roy$1 w produce ! wor/ results40 ---------------------------------------- ---------------- ,to return1 h[ev]1 to ,ph5ol ,sodique3 ,! fold] is also evid5tly int5d$ = ! lay public r ?an = physicians2 at lea/1 if we are to cr$it ,hance ,bros4 ,:ite ) any intellig5ce :atsoev]4 ,x is head$3 8,montyon ,prize ( ,enc\ragem5t1 ,aw>d$ by ! ,in/itute ( ,france1 #ahfa40 ,?is is r anci5t1 b :at foll[s indicates t a little re/ra9t w\ld h be5 bett] ?an enc\ragem5t4 ,! circul> is a compact treatise on self-m$ication--app>5tly all t is necess>y to reta9 or rega9 heal? is ! use ( ,ph5ol ,sodique1 ext]nally & int]nally4 ,! foll[+ conditions are among ^? specifically nam$ z am5able to ?is rem$y4 ,smallpox1 measles1 sc>lat9a1 erysipelas1 pu]p]al fev]1 typhoid fev]1 *ol]a1 di>rhea1 cramps1 burns & scalds1 bites1 cuts & w\nds1 excoriations1 *ilbla9s1 *aps1 sore ?roat1 scrat*es1 cat>rh1 tett]1 sunburn1 swoll5 ve9s1 ulc]s1 hemorrhages1 bruises1 piles1 gangr5e1 c>buncle1 it*+1 insect /+s1 ivy poison1 cold 9 ! head1 bunions1 inflam$ eyes1 eczema1 r+worm1 rheumatism1 pa9s1 too?a*e1 seat worms1 etc4--besides num]\s diseases ( animals4 ,no antiseptic1 :atev] its composition1 c\ld by any possibility accompli% any?+ l :at is claim$ = ,ph5ol ,sodique1 s t ! composition ( ! article is really ( little importance4 ,?is is evid5tly appreciat$ by ! manufactur]s1 = !y h kept ! composition a pr(\nd secret1 except 9 s f> z x is impli$ 9 ! "n4 ,an inquiry address$ to ,hance ,bros4 ,:ite1 "u date ( ,april #bg1 #aijg1 six mon?s ago1 has rema9$ unansw]$4 ,! ,c\ncil1 !re=e1 direct$ an analysis ( ,ph5ol ,sodique4 ,?is 0 c>ri$ out at ! *emical laboratory ( ! ,am]ican ,m$ical ,association1 & a *eck analysis 0 made by an indep5d5t firm ( *emi/s4 ,?is %[s t ,ph5ol-,sodique conta9s some?+ l #j4e or #j4ff p] c5t4 ( ph5ols1 dissolv$ 9 ab\t #j4ge p] c5t4 ( sodium hydroxid4 ,9 o!r words1 x appe>s to be ess5tially a v dilute alkal9e solution ( "s impure coal-t> product1 presumably a crude c>bolic acid4 ,! analysis c\ld n pr(itably be c>ri$ fur!r1 because ! am\nt ( ! antiseptic ag5t is s v small4 ,! consid]ation ( ?is analysis1 9 connection ) ! claims made = ,ph5ol-,sodique1 leaves little d\bt z to "o reason = ! secrecy conc]n+ its composition2 al?\gh no educat$ physician c\ld be deceiv$ into believ+ = a mom5t t ,ph5ol-,sodique c\ld fulfil ! promises ( its promot]s1 ev5 if x 7 8! be/ antiseptic1 hemo/atic & dis9fectant on ! m>ket10 z ! manufactur]s say 9 _! adv]tisem5ts4 ,f its composition1 x c only h ! v mod]ate & ord9>y antiseptic qualities ( a dilute ph5ol or cresol solution1 modifi$ only to a v slight ext5t by ! free alkali4 ,accord+ to ! manufactur]s1 h[ev]1 8,ph5ol-,sodique is a wond]ful prep>ation40 ,j h[ wond]ful appe>s f ^! extracts f ! diss]tations 9 ! pamphlet :i* is enclos$ 9 ! package4 8,cat>rh1 ,old ,colds1 etc4--,dr9k e morn+ & ev5+ a glass ( wat] conta9+ t5 to ?irty drops ( ,ph5ol-,sodique 4440 8,small-,pox4--,to prev5t attack take int]nally ?ree or f\r times a day1 fifte5 or tw5ty drops ( ,ph5ol-,sodique 9 "o tablespoonful ( sug> & wat]4444 8,measles1 ,sc>lat9a & ,erysipelas4--,same treatm5t z = ,small-pox40 8,typhoid ,fev]4--,to prev5t attack take int]nally ?ree or f\r times a day1 fifte5 or tw5ty drops ( ,ph5ol-,sodique40 8,*ol]a4--,to prev5t1 spread sawdu/ or s&1 wet ) ,ph5ol-,sodique1 9 ap>tm5ts4 8,! v be/ precaution is to dr9k1 morn+ & ev5+1 a glass ( wat] conta9+ f fifte5 to ?irty drops ( ,ph5ol-,sodique4444 8444 ,premonitory ,di>rhea4--444 ,dr9k a teaspoonful ( ,ph5ol-,sodique dilut$ 9 an ounce ( wat]44440 ,?is is ! k9d ( !rapeutics & prophylaxis taught to ! m$ical pr(ession by _! self-appo9t$ in/ructors1 ! proprietors6 ,b ?is matt] has a s]i\s z well z a ludicr\s side3 ,:at is ! prop] epi!t to apply to ^? :o1 kn[+ly & int5tionally1 impress on ! ignorant lay public t "o c ) impunity expose himself to smallpox1 *ol]a1 typhoid or sc>let fev]1 or measles1 by tak+ a few drops ( v dilute c>bolic acid1 or by spr9kl+ a little on sawdu/8 ,:at mu/ be ! consequ5ces to ^? :o tru/ 9 ^! assurances8 ,& :at %\ld be ! lawful p5alty = ^? ^: blunt$ moral in/9cts p]mit !m wilfully to endang] ! lives ( o!rs = a little f9ancial ga98 ,x w\ld be int]e/+ to "k ! real op9ion ( ! responsible memb]s ( ! firm ( ,hance ,bros4 ,:ite on ^! que/ions4 ,! ,montyon ,prize 0 aw>d$ by ! ,fr5* ,in/itute 9 #ahfa--;=ty-six ye>s ago--h[ _m victims a ye>8--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #i1 #aijg47 ,,phyt9 ,,& ,,=tossan ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,phyt91 manufactur$ by ! ,society ( ,*emical ,indu/ry1 ,basel1 ,switz]l&1 & sold by ,a4 ,klip/e9 & ,co41 is an organic phosphorus comp\nd said to be ! 8,acid ,calcium-,magnesium ,salt ( ,phyt9ic ,acid 7,inosit ,phosphoric ,acid or ,anhydro-,oxyme?yl5e-,diphosphoric ,acid70 obta9$ f c]eals & legumes4 ,! trade package ( ,phyt9 con/itutes an indirect adv]tisem5t to ! public4 ,! ,c\ncil reject$ ,phyt9 because unw>rant$ & exagg]at$ !rapeutic claims are made = ?is product bas$ on ! entirely undemon/rat$ assumptions3 7#a7 t phosphorus is assimilat$ only f organic comb9ations 7x is ev5 impli$ t ?is mu/ be 9 ! =m ( ,phyt91 & t milk is incapable ( supply+ ! phosphorus ne$s ( infants72 7#b7 t a long li/ ( diseases1 rang+ f rickets to hy/]ia1 are due to d]ang$ phosphorus metabolism2 7#c7 t all ^! diseases are cur$ or m>k$ly b5efit$ by ,phyt94 ,9 brief1 ! claims rehe>se e po9t ( ! m or less discr$it$ phosphorus propag&a1 9 exactly ! same way z x 0 rehe>s$ successively by ! exploit]s ( hypophosphites1 leci?91 glyc]ophosphates1 & amorph\s phosphorus4 ,x is conc$$ by ! writ]s ( ! adv]tis+ pamphlets = ,phyt9 t ! prec$+ claims 7 errone\s2 b no evid5ce is giv5 to w>rant ! belief t ! ,phyt9 claims are less errone\s4 ,! mislead+ /atem5ts are mo/ extreme4 ,by ! use ( bold type p>ticul> /ress is laid on ! prepo/]\s & vici\s claim t ,phyt9 8radically & p]man5tly removes sexual debility40 ,=tossan is a prep>ation ( ,phyt9 & sug> ( milk1 also manufactur$ by ! ,society ( ,*emical ,indu/ry1 ,basel1 ,switz]l&1 & sold by ,a4 ,klip/e9 & ,co4 ,s9ce ,=tossan is a simple prep>ation ( ,phyt9 ! ,c\ncil vot$ t ! rejection ( ,phyt9 %\ld also apply to ,=tossan4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #cj1 #aiae47 ,,prunoids ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,prunoids are tablets put out by ! ,sultan ,drug ,company1 ,/4 ,l\is4 ,!y are said to be3 8,made ( ,ph5olph?ale9 7"o & "o-half gra9s 9 ea*71 ,casc>a ,sagrada1 ,de-emet9iz$ ,ipecac & ,prunes40 ,! foll[+ report on ! composition ( ,prunoids is submitt$ by ! ,association's ,laboratory3 8,f an exam9ation ( ,prunoids x is conclud$ t ! am\nt ( casc>a or extract ( casc>a 9 ! prep>ation is v small4 ,also ! quantity ( 8de-emet9iz$ ipecac0 is insignificant4 ,! claim is made3 8,! levulose ( prunes1 a con/itu5t ( ,prunoids1 is hygroscopic & ?us :5 br\ght into contact ) ! saliva ( ! m\? or cont5ts ( ! /oma*1 dis9tegrates & prompt m$ication is insur$40 8,actually ! am\nt ( prunes :i* may be pres5t 9 ,prunoids is negligible4 ,= all practical purposes1 !re=e1 ,prunoids are ph5olph?ale940 ,accord+ to ! in=mation includ$ on & 9 ! box ,prunoids are 8,an ,ideal ,laxative1 ,purgative1 & ,inte/9al ,tonic0 444 8p>ticul>ly adapt$ to ! treatm5t ( con/ipation 4440 ,!y are said to act z an 8inte/9al tonic0--a claim :i* 9 ! light ( ! exam9ation is obvi\sly unw>rant$--& because ( ?is1 x is said t !y3 8,w p]man5tly remove con/ipation )\t caus+ aft] con/ipation40 ,! trade package assures ! pur*as] t ,prunoids are3 8,recomm5d$ by ,physicians ,g5]ally40 ,a circul> s5t to physicians makes ! unw>rant$ claim t ,prunoids are 8especially s]viceable0 9 8444 ,neura/h5ia1 ,jaundice1 ,*lorosis1 ,rheumatism1 ,g\t 4440 & t 8444 _! success 9 g\ty dia!sis & vague rheumatic symptoms t5ds to confirm ! op9ion express$ by "s physicians t !y h a solv5t action on uric acid40 ,9 ! foll[+ ! haphaz>d & ill-consid]$ use ( purgatives is sugge/$3 8,= ! expectant "m1 or 9 ! treatm5t ( female diseases1 = b[el elim9ation1 no happi] or saf] selection c be made40 ,! ,c\ncil refus$ recognition to ,prunoids because ! /atem5t ( composition is incomplete & !re=e mean+less2 because unw>rant$ !rapeutic claims are made = !m2 because ! "n 8,prunoids0 gives ! false impression t !y dep5d on prunes = _! effect2 & because x is irrational & a detrim5t to m$ic9e to disguise a well-kn[n drug by means ( a mislead+ "n & to attempt to create ! impression ( special virtues by comb9+ x ) sup]flu\s drugs4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #b1 #aiae47 ,,sal ,,hepatica ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,sal ,hepatica1 m>ket$ by ! ,bri/ol-,my]s ,co4 ( ,new ,york1 has be5 refus$ recognition by ! ,c\ncil1 because its composition is secret2 because x is adv]tis$ indirectly to ! public = ! treatm5t ( diseases2 because exagg]at$ & unw>rant$ claims are made = its !rapeutic qualities2 & because ! "n fails to indicate its *ief con/itu5ts b does sugge/ its use 9 liv] disord]s4 ,! ,c\ncil has au?oriz$ ! publication ( ! report ( its ref]ee1 because x is an important illu/ration ( ! ways 9 :i* physicians are be+ made p>ties to ! introduction to ! public ( a pat5t m$ic9e1 ^: indiscrim9ate use mu/ (t5 h result$ 9 h>m1 direct or indirect4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,! report ( ! ref]ee foll[s3 ,sal ,hepatica is a sal9e laxative sold by ! ,bri/ol-,my]s ,company ( ,new ,york4 ,no in=mation seems to be giv5 reg>d+ its composition except su* z is conta9$ 9 ! foll[+ vague & un9=m+ phrases3 8,eff]vesc5t sal9e comb9ation1 hepatic /imulant1 laxative & an elim9ant ( irritat+ tox9s40 8,sal ,hepatica is a sal9e comb9ation conta9+ ! alt]ative & laxative prop]ties simil> to ! natural #8,bitt] ,wat]s' ( ,europe ) ! addition ( sodium phosphate40 8444 m palatable & effici5t ?an sodium phosphate alone or o!r sal9es40 ,a circul> ar\nd ! bottle conta9s ! foll[+3 8,we invite ! physicians' c>eful consid]ation ( ! m]its ( ,sal ,hepatica 9 ! treatm5t ( ,rheumatism & ,g\t1 9 ,con/ipation & ,auto-intoxication1 & to its highly important prop]ty ( cleans+ ! entire alim5t>y tract1 !reby elim9at+ & prev5t+ ! absorption ( irritat+ tox9s & reliev+ ! conditions aris+ f indiscretion 9 eat+ & dr9k+40 ,9 ! same circul>1 its promiscu\s use is invit$ 9 ^! t]ms3 8,ow+ to its palatability1 ,sal ,hepatica is p>ticul>ly well adapt$ to ! requirem5ts ( *ildhood or ! feeble & delicate40 ,fur!r sugge/+ its use 9 ! treatm5t ( t popul>1 if some:at vague ailm5t1 8bili\sness10 we read3 8,x is especially valuable :]e !re is inte/9al sluggi%ness aris+ f functional d]angem5ts ( ! liv] or portal circulation44440 ,z fur!r sugge/ive ( its all-ar\nd 8goodness10 are ! claims3 8,x increases ! appetite & promotes dige/ion by /imulat+ ! fl[ ( ga/ric juice40 8,9 rheumatism & g\t ,sal ,hepatica furni%es ! physician ) an ideal elim9ant1 usually af=d+ prompt relief40 ,! label on ! ,sal ,hepatica bottle sugge/s--bo? to physicians & to ! public--its use 9 ! foll[+ diseases & conditions3 8,d]angem5ts ( ! /oma* & liv]40 8,affections ( ! kidneys40 8,bili\s attacks40 8#8,summ] compla9ts1' colic & alcoholic excesses40 8,heada*e1 dizz9ess1 he>tburn & seasickness40 8,acute indige/ion40 8,ga/ric1 hepatic & r5al disord]s40 8,especially b5eficial 9 rheumatism & g\t40 ,f ^! quotations x is evid5t t ,sal ,hepatica is 9 conflict )3 ,rule #a1 9 t its composition is n disclos$1 al?\gh /atem5ts are made :i* are likely to give a false impression z to :at x is2 ,rule #d1 9 t ! /atem5ts on ! label & 9 ! circul> ar\nd ! bottle adv]tise x to ! public & ?us make ! physician :o recomm5ds x an advance ag5t = ! no/rum2 ,rule #f1 9 t exagg]at$ & unw>rant$ claims are made = its !rapeutic qualities1 &1 ,rule #h1 9 t its "n fails to indicate its *ief con/itu5ts1 b does sugge/ its use 9 liv] disord]s4 ,! absurd claims made = ?is prep>ation are su* z to put x 9 ! 8pat5t m$ic9e0 class4 ,ev5 ! mo/ cr$ul\s memb]s ( ! m$ical pr(ession c]ta9ly c take no /ock 9 ! claim t a prep>ation c be an 8elim9ant0 ( uric acid1 a hepatic /imulant1 a rem$y = g\t1 rheumatism1 liv] disease1 indige/ion1 etc4 ,:y !n %\ld su* a prep>ation be tol]at$8 ,9 its conflict ) ,rule #d ,sal ,hepatica belongs to t class ( no/rums :i* h be5 s successfully exploit$ by manufactur]s ?r\gh ! unwitt+ ef=ts ( ?\ghtless & c>eless physicians4 ,! ,bri/ol-,my]s ,company has be5 mo/ lib]al 9 di/ribut+ free samples1 evid5tly ) ! assurance t physicians w\ld d ! re/4 ,?us1 at ! pres5t "t1 ! pr(ession is be+ suppli$ ) a package conta9+ "o regul> #be-;c5t bottle & five s+le-dose vials be>+ ! "n ,sal ,hepatica4 ,if only a small p]c5tage ( ! physicians :o receive ^! samples di/ribute !m1 ! increase 9 ,sal ,hepatica consum]s may be imag9$4 ,h[ successful ?is s*eme ( ! ,bri/ol-,my]s ,company has be5 is only too evid5t4 ,sal ,hepatica is "o ( ! be/-sell+ laxatives 9 dep>tm5t /ores & drug /ores to-day4 ,:ile ! evils ( indiscrim9ate purgation are n[ g5]ally recogniz$1 ! ref]ee wi%es to quote & to indorse ! p]t95t comm5ts on ?is subject by ,! ,j\rnal3#gi #gi ,! ,j\rnal ,a4 ,m4 ,a41 ,m>* #bf1 #aiaj1 p4 #ajga4 8,! abuse ( sal9e ca?>tics by ! public is an evil des]v+ ( s]i\s att5tion4 ,rightly or wrongly1 ! laity fe> con/ipation & naturally take :at !y are taught to believe is ! *eape/ & simple/ c\rse = its relief1 self-drugg+ by means ( sal9e ca?>tics or ! ext5sively adv]tis$ purgative m9]al wat]s4 ,?is habit is responsible = mu* ( ! di/ress+ spa/ic con/ipation t exi/s1 & its accompany+ neura/h5ia4 ,! adv]tisem5t & sale to ! laity ( su* a no/rum z 8,sal ,hepatica0 c only increase ^! evil results & ! physician :o aids & abets ! evil by us+ ! prep>ation %\ld reflect :e!r he is !reby n only enc\rag+ a fraud on ! public b also1 :at is ev5 worse1 help+ to impair ! public heal?40 ,x is recomm5d$ t ?is report be au?oriz$ = publication 9 ord] t physicians may "k ! ext5t to :i* !y h be5 made to act z advance ag5ts = 8pat5t m$ic9es40 ,x is hop$ its publication may sugge/ to ^? :o 9 ?\ghtlessness h recomm5d$ ,sal ,hepatica1 t !y g to _! mat]ia m$ica & r5ew acqua9tance ) ! ho/ ( simple & effici5t laxative salts :i* are available--magnesium sulphate1 sodium sulphate1 sodium phosphate & ! palatable eff]vesc+ prep>ations ( ^! :i* ! ,ph>macopeia provides--eff]vesc5t magnesium sulphate 7,magnesii ,sulphas ,eff]vesc5s1 ,u4 ,s4 ,p471 eff]vesc5t sodium phosphate 7,sodii ,phosphas ,eff]vesc5s1 ,u4 ,s4 ,p474--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,feb4 #g1 #aiad47 ,,sanmetto ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! foll[+ report on ,sanmetto 7,od ,*emical ,company1 ,new ,york7 has be5 adopt$ by ! ,c\ncil on ,ph>macy & ,*emi/ry1 :i* au?oriz$ its publication4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,sanmetto is "o ( ! olde/ propriet>ies on ! m>ket4 ,its adv]tisem5ts h be5 famili> to ! read]s ( m$ical j\rnals = sev]al decades pa/4 ,x is a typical no/rum4 ,x is secret al?\gh ! promot]s h publi%$ v>i\s 8ne>-=mulas40 ,! foll[+ are "s ( ! /atem5ts reg>d+ composition3 8,a ,sci5tific ,bl5d+ ( ,true ,santal & ,saw ,palmetto ) ,soo?+ ,demulc5ts 9 a ,pleasant ,aromatic ,vehicle40 ,z ?is did n disclose ! id5tity ( ! demulc5ts or ! quantity ( ! alleg$ active con/itu5ts1 ! 8=mula0 01 ( c\rse1 mean+less4 ,aga9 x is3 8,a ,sci5tific bl5d+ ( true ,santal & ,saw ,palmetto 9 a pleasant aromatic vehicle40 ,"h ! ref]5ce to 8soo?+ demulc5ts0 is omitt$4 ,! in=mation furni%$ physicians at ! pres5t "t is3 8,x is a bl5d ( h>moniz+ drugs40 ,a lett] f a physician reque/+ in=mation z to ! exact composition ( ,sanmetto rec5tly elicit$ ! foll[+ reply3 8444 ,sanmetto is a bl5d+ ( true santal & saw palmetto ) soo?+ demulc5ts 9 a pleasant aromatic vehicle4 ,! demulc5ts are introduc$ n only = ! purpose ( modify+ ! irritant prop]ties ( ! santal1 b to add di/9ctively to ! soo?+ prop]ties ( ! f9i%$ product ^u ! muc\s membrane ( ! ur9>y tract1 & are n m5tion$ 9 our publi%$ =mula = ! simple fact t if we gave !m1 !n we w\ld d ! adv]tis+ & ! sub/itute manufactur] w\ld engage 9 ! #8unfair competition' ( putt+ on ! m>ket 8 concoction1 claim+ to be made exactly aft] our =mula1 )\t sp5d+ a c5t = adv]tis+1 rely+ ^u our propag&a "w to sell 8 sub/itute1 al?\gh n ! same article z nor equival5t to ,sanmetto1 f ! fact t he w\ld be work+ 9 ! d>k z to ! processes 9 ! manufacture ( our product4 ,!re is no m9]al sub/ance 9 ,sanmetto1 nor any o!r +r$i5t t is detrim5tal 9 any way :atsoev]4444 8,,od ,,*em4 ,,co41 8,m4 ,haman1 ,pres't40 ,,! ,,value ,,( ,,santal ,,& ,,saw ,,palmetto ,! =ego+ w>rants ! assumption t ! active +r$i5ts ( ! mixture are s&alwood oil & saw palmetto4 ,!re 0 a p]iod :5 ! int]nal treatm5t ( gonorrhea _h a m>k$ vogue4 ,balsamic rem$ies receiv$ ! approbation ( ! m$ical pr(ession z ! mo/ specific ( int]nal rem$ies = ?is disease4 ,z a repres5tative ( ?is class1 s&alwood oil 0 v highly e/eem$ & _h great popul>ity4 ,z 9 o!r simil> in/ances1 ?is popul>ity 0 comm]cializ$ & ! drug became ! basis ( _m secret or semisecret mixtures1 includ+ 8specialties0 ( ph>maceutical h\ses4 ,sabal or saw palmetto is an (ficial drug :i* at "o "t 0 us$ 9 g5ito-ur9>y affections1 b n[ is seldom us$1 presumably because x has be5 f\nd practically wor?less4 ,x is n m5tion$ by mo/ ph>macologi/s1 & ^? :o d m5tion x reg>d x z ( d\btful value4 ,x is includ$ among ! prep>ations recomm5d$ = deletion z giv5 9 ! report ( ! ,committee on ! ,ph>macopeia ( ! ,am]ican ,m$ical ,association 7,! ,j\rnal1 ,sept4 #d1 #aiji1 p4 #gib74 ,ev5 grant+ t s&alwood oil & saw palmetto d h !rapeutic value1 no "o w\ld ?9k ( reg>d+ ei!r or bo? ( ^! prep>ations z ( use except 9 inflammatory conditions ( ! g5ito-ur9>y tract1 especially gonorrhea4 ,if "o is to believe ! adv]tisem5ts1 h[ev]1 ! comb9ation ( ^! drugs 9 ,sanmetto is a wond]ful m$ic9e4 ,"o might ev5 conclude t !re are few conditions 9 :i* x _c be giv5 ) pr(it4 ,= in/ance3 8,9 ,n]v\s ,diseases1 especially ,neura/h5ic cases ) orig9 9 "s sexual or g5ito-ur9>y disord]1 = its action z a vitaliz+ tonic & recon/ructive1 re/or+ nutrition to g]m plasm1 reliev+ pa?ological conditions & = soo?+ & su/a9+ ! n]ves controll+ ! p>ts40 ,be> 9 m9d 9 read+ ! =ego+ /atem5t & ! foll[+ t we are conc]n$ ) two drugs ^: effects are ex]t$ on muc\s membranes especially ( ! g5ito-ur9>y tract4 8,9 ,ge/ation ,cases1 %[+ t5d5cy to album9 & convulsions1 = ton+ ! pelvic organs1 cle>+ up ! ur9e & cleans+ ! ur9>y bladd] & outlet4 ,9 ! ,ly+-9-,room = reliev+ ! affections ( ure?ra & bladd]1 pa9ful /rangury ( ! ure?ra & pa9ful micturition due to ! pressure ( ftal head ^u ! neck ( ! bladd] & ^u ! ure?ra dur+ labor1 & infection1 ei!r septic or gonorrheal40 8,9 ,weakness ( ! ,kidneys1 caus+ loss 9 tone & g5]al heal? & ,impairm5t ( ,eyesight--= /r5g!n+ ! kidneys & bladd] & ton+ ! n]v\s sy/em2 & also = aid+ 9 ! con/itutional treatm5t ( ,gonorrheal ,infection ( ! ,eyes4 8,9 ! treatm5t ( ! ,pro/ate1 ,te/es1 ,mamm1 ,ov>ies1 & ,ure?ra1 ,kidneys & ,bladd]1 = its soo?+1 slightly antiseptic1 aphrodisiac1 ton+ & re/or+ action to ! muc\s membrane & gl&s4 ,by its use ! p>ts affect$ 9 _m cases return+ to _! normal condition40 ,:ile ! ref]5ce to its aphrodisiac action & to ! re/oration ( p>ts to ! normal may h little int]e/ to physicians1 x may be c\nt$ on to appeal to ! sexual neura/h5ic4 ,9 premature s5ility3 8,sanmetto 444 is unexcell$ z a vitaliz+ tonic to ! )]$ gl&s ( ! reproductive sy/em1 promot+ _! normal secretory activity40 ,^! claims are n only absurd b also h>mful2 !y t5d to p]petuate a hypo*ondriacal /ate ( m9d 9 ! class ( pati5ts appeal$ to--! sexual neura/h5ic4 ,!re is1 h[ev]1 a m s]i\s side2 ! t5d5cy ( c]ta9 o!r claims made = ! prep>ation are vici\s & dang]\s z well z mislead+4 ,! adv]tis+ claims are likely to induce "s physicians--^? :o accept adv]tis+ 8lit]ature0 z dep5dable--to belittle ! importance ( s]i\s diseases ( ! sexual organs & to be cont5t ) ,sanmetto1 :i*1 ev5 if x gave z good results z o!r balsamic rem$ies1 w\ld be1 at be/1 only a halfway measure4 ,?is 9 an adv]tis+ pamphlet physicians are giv5 ?is advice z to ! treatm5t ( gonorrhea4 8,to provide ! ne$$ re/ ! pati5t %\ld be in/ruct$ to simply keep ! p>ts clean ) w>m wat] = ! fir/ week & let ! dis*>ge cont9ue until y c control x by int]nal m$ication4 ,i wi% to emphasize ! fact t !re is no way t any acutely inflam$ portion ( ! g5ito-ur9>y tract c get ! re/ requir$ s completely z by adm9i/ration ( ,sanmetto4444 ,aft] ! acute gonorrhea has begun to subside ! ,sanmetto %\ld be aid$ by mild a/r+5t injections40 ,if !re is any well-e/abli%$ fact 9 m$ic9e1 x is t gonorrhea is a s]i\s disease--s]i\s alike to ! suff]] & to ! community--& "o :i* ne$s c>eful att5tion f ! v fir/4 ,to claim1 ei!r directly or by implication1 t x c be cur$ by su* a mixture design$ to act on ! kidneys1 bladd] & n]v\s sy/em is false & dang]\s doctr9e4 ,! physician :o prescribes ,sanmetto prescribes a secret m$ic9e = conditions :i* he is presumably compet5t to treat ) simple rem$ies ( :i* he kn[s ! orig9 & action & :i* he c v>y to suit ! ne$s ( ! individual4 ,sanmetto is a secret no/rum ! exploitation ( :i* is an invitation to haphaz>d1 uncritical !rapy & a m5ace to public heal?4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,m>* #ac1 #aiae47 ,,secretog5 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has au?oriz$ publication ( ! foll[+ report deal+ ) two int]nal secretion specialties--,secretog5 ,elixir & ,secretog5 ,tablets--to call att5tion to ! unf\nd$ & extravagant claims made = ?is class ( products4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,te/ tube exp]im5ts %[ t peps9 hydrolyzes prote9s 9 acid solutions2 t pancreat9 dige/s prote9 9 alkal9e liquids1 & t dia/ase conv]ts />* into sug>4 ,bas$ on ^! facts1 x 0 assum$ t ^! f]m5ts w\ld aid dige/ion4 ,?is assumption 0 correct if limit$ to c]ta9 cases ( dyspepsia 9 :i* x c be %[n t c]ta9 f]m5ts are abs5t or defici5t4 ,b ?is limitation 0 n realiz$ or rememb]$2 on ! contr>y1 ! indiscrim9ate use ( dige/+ f]m5ts 9 all k9ds ( cases ( indige/ion became widespread & /ill cont9ues1 al?\gh to a less ext5t4 ,h]e9 lies ! great disappo9tm5t t has foll[$ ! use ( ^! f]m5ts4 ,m rec5tly hormones 7 discov]$1 & :ile _! importance has n be5 fully work$ out1 x has be5 assum$ t !y are responsible = ! secretion ( dige/ive f]m5ts1 & t 9 _! abs5ce ?is secretion fails4 ,)\t wait+ = pro( ( ?is assumption1 t is1 t dige/ive failure is due to lack ( hormones1 propriet>y m$ic9e promot]s are already plac+ on ! m>ket v>i\s secretion specialties4 ,z an example ( ?is new class ( specialties & ( ! unf\nd$ claims made = !m1 y\r ref]ee pres5ts ! foll[+ report on ,secretog5 ,elixir & ,secretog5 ,tablets (f]$ to physicians by ! ,g4 ,w4 ,c>nrick ,company4 ,secretog5 ,elixir is said to conta9 pancreatic secret9 obta9$ f ! duod5um ) #a_/aj ( #a p] c5t4 ( hydro*loric acid4 ,secretog5 ,tablets are said to be prep>$ f pure secret9 & succus ent]icus obta9$ f ! epi!lial cells ( ! duod5um4 ,! claims = ,secretog5 are bas$ on ! physiologic action ( secret9 z describ$ by v>i\s obs]v]s4 ,to det]m9e :e!r ^! claims are ju/ifi$ x becomes necess>y to review ! evid5ce advanc$ to prove t secret9 /imulates ! dige/ive gl&s4 ,secret9 is a hormone1 a *emical sub/ance produc$ by ! action ( hydro*loric acid on a previ\sly =m$ sub/ance1 8prosecret910 conta9$ 9 ! cells ( ! inte/9al muc\s membrane1 especially ( ! duod5um4 ,secret9 is absorb$ by ! blood & c>ri$ to ! pancreas1 liv] & inte/9al mucosa1 :i* are !reby /imulat$ to produce _! *>act]i/ic secretions1 namely1 bile1 pancreatic juice & succus ent]icus4 ,:5 secret9 is inject$ into ! blood1 x causes an increase 9 ! fl[ ( ^! secretions4 ,"s obs]v]s h claim$ t secret9 is abs5t 9 cases ( diabetes 9 :i* ! pancreas is /ill f\nd normal4 ,w5twor?#hj report$ sev]al cases ( m>asmus 9 :i* he f\nd no evid5ce ( prosecret94 ,?is defici5cy1 he believes1 is ! cause ( ?is disease4 #hj ,w5twor?1 ,a4 ,h43 ,! ,cause ( ,infantile ,atrophy1 ,d$uc$ f a ,/udy ( ,secret9 9 ,normal & ,atrophic ,infants1 ,! ,j\rnal ,a4 ,m4 ,a41 ,july #bj1 #aijg1 p4 #bjd4 ,! ,c>nrick ,company1 adopt+ ! =ego+ views1 namely1 t secret9 is necess>y to secure ! normal action ( pancreas1 liv] & inte/9e1 z prov$1 plac$ on ! m>ket _! specialty 8,secretog510 to take ! place ( ! miss+ secret94 ,! =ego+ conclusion _c1 h[ev]1 be su/a9$4 ,!re are num]\s cases 9 :i* no hydro*loric acid is produc$ 9 ! /oma* & h5ce--z x is produc$ by ! action ( hydro*loric acid--no secret9 c be produc$ 9 ! inte/9e4 ,yet 9 ^! cases ! pancreatic juice & bile are secret$ 9 normal am\nts & dige/ion goes on normally aft] ! food leaves ! /oma*4 ,9 su* cases ! pancreas & liv] mu/ be /imulat$ to secretion by "s o!r me*anism ?an secret94 ,! pro( t ! abs5ce ( secret9 is *>act]i/ic ( diabetes or ( m>asmus is n yet available4 ,sweet & ,pemb]ton#ha f\nd t _m circum/ances int]f]$ ) ! extraction ( secret91 s t ! m]e failure to obta9 x 9 a giv5 case is n pro( ( its abs5ce1 unless ! v>i\s inhibit+ influ5ces are giv5 due consid]ation4 ,! conclusions rea*$ by ^! au?ors are t 8! evid5ce s f> adduc$ t secret9 is abs5t 9 "s v>ieties 7( diabetes7 does n seem conclusive10 & t 8! specific abs5ce or defici5cy ( secret9 9 m>asmus seems to rema9 z yet unprov540 #ha ,sweet1 ,j4 ,e41 & ,pemb]ton1 ,r43 ,exp]im5tal ,obs]vations on ,secret91 ,ar*4 ,int4 ,m$41 ,febru>y1 #aijh1 p4 #bca4 ,! favorable reports ( ,moore#hb 9 reg>d to ! use ( secret9 9 diabetes are n confirm$ by ! exp]i5ce ( ,fo/]#hc 9 five cases1 or by ! case report$ by ,dak9 & ,ransom4#hd #hb ,moore1 ,edie & ,abram3 ,bio*em4 ,j\r41 #aijf1 i1 #bh2 ibid41 i1 #ddf4 #hc ,fo/]1 ,n4 ,b43 ,cases ( ,diabetes ,treat$ ) ,secret91 ,j\r4 ,biol4 ,*em41 ,janu>y1 #aijg4 #hd ,dak91 ,h4 ,d41 & ,ransom1 ,c4 ,c43 ,treatm5t ( ,case ( ,diabetes ) ,secret91 ,j\r4 ,biol4 ,*em41 ,janu>y1 #aijg4 ,9 reg>d to ! use ( secret9 9 inte/9al disord]s1 ! ,g4 ,w4 ,c>nrick ,company ref]s to an article by ,j4 ,w4 ,bev]idge4#he ,an exam9ation ( ?is article %[s x to be unsci5tific & uncritical4 ,! au?or pres5ts f\r cases to 8demon/rate ! peculi> pot5cy ex]cis$ by secret940 ,( ! fir/ he says3 #he ,bev]idge1 ,j4 ,wallace3 ,secret91 ,am4 ,j\r4 ,ga/ro-,ent]ology1 ,april1 #aiad1 p4 #agj4 8,/oma* 0 dilat$1 food delay1 sev5ty-two h\rs2 hyp]acidity1 vomit+ daily1 five to twelve times1 ur9e high specific gravity1 ov] #c p] c5t4 urea1 trace album540 ,! pati5t improv$ some:at aft] ga/ro-ent]o/omy ) removal ( ! gallbladd]2 ! vomit+ ceas$1 b ! /ools cont9u$ clay-color$ & ! high urea output /ill kept up4 ,secret9 0 giv51 & aft] ?is ! report cont9ues3 8,! /ools became normal 9 color at ! end ( ! second mon?1 weight gradually increas$ until #abb-c_/d p\nds 0 rea*$1 & ! urea is n[ normal1 av]ag+ ab\t #a p] c5t40 ,?is case is (f]$ to prove ! abs5ce ( secret9 & its effect :5 giv5 by ! m\?4 ,z evid5ce ( hepatic insuffici5cy ! au?or app>5tly relies on ! color ( ! /ools1 & = pancreatic insuffici5cy he cites ! high urea output4 ,he claims t :5 ! pancreas does n furni% an effici5t secretion1 ! prote9s ( ! food fail to be conv]t$ into am9o-acids1 & in/ead1 raise ! p]c5tage ( urea4 ,consequ5tly1 he concludes t a high p]c5tage ( urea indicates ! abs5ce ( secret94 ,x is usually held t a high p]c5tage ( urea dep5ds on two factors1 +e/ion ( a l>ge am\nt ( prote9 & conc5tration ( ! ur9e4 ,! au?or gives no data z to ! am\nt ( album9\s food1 ! am\nt ( ur9e1 or :e!r ! p]c5tage ( urea 0 le>n$ by exam9+ a s+le specim5 or ! total quantity = tw5ty-f\r h\rs4 ,! milde/ judgm5t t c be pass$ on su* cl9ical data is t !y are totally inadequate4 ,)\t d\bt ! p]c5tage ( urea c\ld h be5 r$uc$ to 8normal0 by caus+ ! pati5t to dr9k wat] freely4 ,! rema9+ cases %[ simil> ha/y conclusions f insuffici5t data1 r5d]+ !m wor?less z evid5ce4 ,! ,g4 ,w4 ,c>nrick ,company introduces a numb] ( te/imonials z to ! value ( ,secretog54 ,^! te/imonials are simil> to all te/imonials4 ,!y include no evid5ce ( c>eful diagnosis1 & pres5t an uncritical e/imate ( ! results4 ,!y %[ t ! writ]s h giv5 ,secretog5 ,elixir or ,tablets indiscrim9ately 9 almo/ ! :ole range ( dige/ive disord]s1 9 nephritis1 neuralgia1 liv] disease & gall/ones1 exoph?almic goit]1 neura/h5ia1 epilepsy1 etc4 ,z dep5dable evid5ce1 ^! te/imonials are n wor?y ( consid]ation4 ,a rational basis = ! !rapeutic value ( ,secretog5 is lack+ = ! foll[+ reasons3 #a4 ,no evid5ce has be5 pres5t$ t ! abs5ce ( secret9 is a cause ( ga/ro-inte/9al diseases4 ,x is usually pres5t1 & if n pres5t1 z 9 a*ylia ga/rica1 !re is evid5tly "s comp5sat+ arrangem5t by :i* ! pancreas is /imulat$ to p]=m its regul> functions4 #b4 ,!re is no evid5ce t secret9 9 any =m is physiologically active :5 adm9i/]$ by ! m\?4 ,,ref]5ces ,fleig1 ,m4 ,c43 ,action de la scrt9e1 ,ar*4 gn4 de md41 lxxx1 #bd4 ,*>les1 ,j4 ,r43 ,treatm5t ( ,diabetes ) ,secret91 ,bri/ol ,m$4-,*ir4 ,j\r41 ,septemb]1 #aijf2 ,m$4 ,press & ,circul>1 ,nov4 #ba1 #aijf4 ,meltz]1 ,s4 ,j43 ,animal ,exp]im5tation 9 ,relation to our ,k ( ,secretions1 ,especially 9 ,int]nal ,secretions1 ,! ,j\rnal ,a4 ,m4 ,a41 ,may #g1 #aiaj1 p4 #aejf4 ,w5twor?1 ,a4 ,h43 ,! ,cause ( ,infantile ,atrophy1 ,d$uc$ f ,a ,/udy ( ,secret9 9 ,normal & ,atrophic ,infants1 ,! ,j\rnal ,a4 ,m4 ,a41 ,july #bj1 #aijg1 p4 #bjd4 ,bambridge & ,b$d>d3 ,guy's ,hospital ,reports1 #aijg1 lxi1 #afa4 ,enriquez & ,hallion3 ,nuevas nociones sobre la dige/ion4 ,secret91 ,importancia fisiologica y patologica1 ,transactions ( #ad? ,int4 ,m$4 ,congress1 ,madrid1 #aijd4 ,enriquez3 ,la ,scrt9e ,mdication acide duodnale ,/imulation de function scrt9iques *ez l'homm41 ,rev4 de4 ?rap4 md4-*ir41 ,p>is1 #aijd1 lxxi1 #ahg4 --7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,may #a1 #aiae47 ,,s9k9a ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,s9k9a is a mal>ia 8cure0 put on ! m>ket by ! ,metropolitan ,ph>macal ,company1 ,new ,york4 ,! product 0 pres5t$ to ! ,c\ncil on ,ph>macy & ,*emi/ry = admission to ,new & ,non(ficial ,rem$ies & 0 reject$ because insuffici5t evid5ce 0 submitt$ to sub/antiate ! improbable claims made = x4 ,! manufactur]s 7 s5t a copy ( ! report /at+ t _! product 0 refus$ recognition4 ,9 view ( ! adv]tis+ t 0 p]si/$ 9 aft] its rejection1 ! ,c\ncil's ref]ee = ,s9k9a submitt$ ! prep>ation to cl9ical te/s4 ,bo? ! orig9al report & ! results ( ! cl9ical te/s are giv5 9 ! foll[+ report1 :i* 0 submitt$ to ! ,c\ncil & recomm5d$ = publication4 ,! complete report hav+ be5 s5t to ! manufactur]s & _! reply consid]$1 ! ,c\ncil au?orizes its publication4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,,! ,,c\ncil',s ,,fir/ ,,report ,! ,c\ncil1 aft] inve/igat+ ! claims made = ,s9k9a1 decl>$ ! product unwor?y ( recognition & adopt$ ! foll[+ report1 :i* 0 s5t to ! manufactur]s3 ,no exp]im5tal evid5ce reg>d+ ! !rapeutic value has be5 submitt$4 ,! cl9ical evid5ce is scant & n ( su* "* z to des]ve mu* consid]ation1 no suffici5t precautions hav+ be5 adopt$ to avoid wrong conclusions4 ,judg+ f ! evid5ce at h& ! prep>ation is simply a dilute sug>-alcohol-wat] solution conta9+ a little oil ( cum9--,roman c>away4 ,x is highly improbable t su* a liquid w\ld h ! !rapeutic effects claim$ = x by ! ,metropolitan ,ph>macal ,company4 ,9 view ( ! improbable claims made = ,s9k9a1 & ! failure to sub/antiate !m by suitable evid5ce1 x is recomm5d$ t ! prep>ation be refus$ recognition )\t at ?is "t consid]+ ! claims made 9 reg>d to ! id5tity & am\nt ( ! drug claim$ to be ! ess5tial con/itu5t4 ,9 spite ( its rejection ,s9k9a 0 p]si/5tly adv]tis$4 ,x 0 ?\ght advisable1 !re=e1 to submit ! prep>ation to cl9ical te/s4 ,?is 0 done & ! results are giv5 9 ! foll[+ report3 ,,! ,,cl9ical ,,report ,! foll[+ quotations indicate ! claims made = ?is prep>ation3 8,9 mal>ial conditions !re is no?+ t acts s promptly & efficaci\sly z ,s9k9a4 ,s9k9a de/roys radically e trace ( ! p>asite 9 ! blood f ! "t ( its fir/ appe>ance1 builds up ! damag$ corpuscles1 revitalizes ! sy/em1 & completely elim9ates e trace ( ! disease4 ,s9k9a is des]v$ly t]m$ ! ,specific = ,mal>ia40 ,^! claims 7 support$ by te/imonials :i* usually gave no indication ( a demon/ration ( ! pres5ce or abs5ce ( mal>ial plasmodia 9 ! blood4 ,! foll[+ is an example %[+ ! "* ( mo/ ( ! evid5ce pres5t$ by ! manufactur]s3 8,?ree weeks ago ,i prescrib$ ,s9k9a = a negro man #dj ye>s ( age suff]+ f a d\ble t]tian mal>ial infection hav+ a *ill e aft]noon = f\r consecutive days4 ,he came to my (fice ab\t #h a4 m4 & 0 due to h a *ill ab\t #f p4 m4 ,i gave him ! sample ( ,s9k9a & direct$ him to take a tablespoonful at once1 also at noon & aga9 at #d p4 m41 & to cont9ue tak+ x 9 same size dose ?ree times a day till he _h tak5 x all4 ,he report$ to me 9 a week f t date & told me he 0 feel+ f9e & t he hadn't _h any m *ills4 ,! pati5t up to ?is "t is app>5tly cur$40 ,z ! claims 7 support$ by a few te/imonials purport+ to be bas$ on exact inve/igations1 ! ,c\ncil submitt$ ! prep>ation to c>eful laboratory & cl9ical te/s4 ,= ?is inve/igation ! ,c\ncil 0 =tunate 9 secur+ ! help ( physicians actively engag$ 9 ! /udy ( mal>ia4 ,exp]im5ts 7 made 9 vitro ) ! prep>ation2 #a ounce ( ,s9k9a 0 us$1 & its action 0 comp>$ ) t ( #aj gra9s ( qu99 sulphate4 ,:5 ^! 7 add$ to cultures ( mal>ial plasmodia 9 proportion correspond+ to #a ounce ( ,s9k9a or #aj gra9s ( qu99 sulphate = a #aej-p\nd man1 ! qu99 0 f\nd to be unfail+ly antagoni/ic to ! mal>ial organism1 ! drug prev5t$ ! segm5tation ( ! organism1 & f9ally kill$ x 9 ab\t ?irty-six h\rs4 ,! ,s9k9a did n kill ! p>asite aft] sev5ty-two h\rs ( cont9u$ action1 & ! p>asites segm5t$ 9 ! pres5ce ( x j z actively z !y did 9 ! control4 ,! inve/igator 0 furni%$ ) two sets ( prep>ations 9 pla9 prescription bottles s z to avoid all influ5ce ( ! p]sonal equation4 ,"o set consi/$ ( ,s9k9a1 ! o!r ( a mixture ( alcohol1 sug> & wat] ) "s oil ( cum94 ,! inve/igator report$ t1 s f> z ! te/s on ! cultures ( mal>ial plasmodia 7 conc]n$1 he c\ld n det]m9e any diff]5ce 9 ! results obta9$ ) ! oil ( cum9 prep>ation1 made 9 ! laboratory ( ! ,association1 & ^? obta9$ ) ! ,s9k9a ( ! ,metropolitan ,ph>macal ,company4 ,cl9ical trials 7 made by ?ree indep5d5t inve/igators4 ,two ( !m receiv$ ! two sets ( prep>ations describ$4 ,,fir/ ,,inve/igation ,! fir/ inve/igator treat$ two cases ) ,s9k9a3 "o 0 ( ! ord9>y e/ivo-autumnal type & ! o!r an ord9>y t]tian4 ,,cases #a ,,& #b4--;,a good _m s*izonts 7 pres5t 9 ! blood ( ea* pati5t =ty-eight h\rs aft] ! adm9i/ration ( ,s9k9a4 ,9 ! in/ance ( ! case ( t]tian ! pati5t _h 8 *ill =ty-eight h\rs aft] ! m$ic9e _h be5 />t$4 ,z ! ,s9k9a fail$ to produce any effect ! pati5ts 7 !n put on qu99 to /op ! disease4 ,,case #c4--,! pati5t _h tak5 #aj gra9s ( qu99 on ! day on :i* ! exp]im5t 0 begun4 ,he _h ! t]tian =m ( ! disease1 & plasmodia 7 q num]\s at ! beg9n+4 ,! qu99 0 discont9u$ & ,s9k9a 0 giv5 9 doses ( #a ounce ?ree times a day4 ,! day foll[+ ! adm9i/ration ( #aj gra9s ( qu99 & #a ounce ( ,s9k9a1 no p>asites c\ld be f\nd 9 ! blood4 ,! ,s9k9a 0 cont9u$ 9 ! doses m5tion$4 ,on ! sev5? day ! pati5t _h ano!r *ill1 & a great _m p>asites 7 f\nd 9 8 blood4 ,! ,s9k9a 0 discont9u$ & ! pati5t 0 at once reliev$ by qu994 ,?is inve/igator gives x z 8 op9ion1 bas$ on ^! obs]vations1 t ! prep>ation 7,s9k9a7 is absolutely wor?less 9 ! treatm5t ( mal>ia1 & he does n ?9k x necess>y to make any fur!r exp]im5ts ) x4 ,,second ,,inve/igation ,! second inve/igator treat$ two cases ( t]tian mal>ial fev] ) ^! prep>ations until x 0 satisfactorily prov$ t ! drug 0 hav+ no effect on ! pres5ce ( ! p>asites 9 ! blood1 :5 he began ! adm9i/ration ( qu994 ,,case #d4--;,aft] ! use ( ! rem$ies = "o week ! inve/igator /ill f\nd "y r+s half-gr[n & gametes pres5t 9 ! blood4 ,app>5tly !re 0 a relative increase 9 ! numb] ( p>asites4 ,he !n began ! adm9i/ration ( qu994 ,blood-sme>s tak5 ! next day aft] #dj gra9s ( qu99 _h be5 tak5 %[$ "o p>asite aft] eighte5 m9utes' se>* ( "o slide1 & two aft] ?irty m9utes' se>* ( a second slide4 ,at ! end ( a week's treatm5t ! pati5t 0 dis*>g$ recov]$4 ,! blood exam9ation ( two slides 0 negative4 ,,case #e4--,?is 0 a case ( t]tian mal>ia4 ,aft] treatm5t = five days ) ,s9k9a ! blood /ill %[$ t]tian p>asites ) increase 9 ! size ( ! sple51 & ! prep>ation 0 )\t effect on ! cl9ical c\rse ( ! disease4 ,qu99 0 !n begun1 & ! blood exam9ation became negative at ! end ( ?ree days4 ,! inve/igator concludes t ! prep>ations furni%$ him 7 absolutely wor?less 9 ! treatm5t ( two cases ( ! t]tian =m ( mal>ial fev]1 & t ^! solutions _h no effect on ! pres5ce ( ! p>asites 9 ! p]iph]al circulation4 ,9 a case ( qu>tan mal>ia1 bo? ( ! prep>ations 7cum9 oil mixture & ,s9k9a71 s5t by ! ,association ,laboratory1 7 )\t effect on ! plasmodia 9 ! blood4 ,?is inve/igator employ$ ! solution made by ! ,association ,laboratory 7cum9 oil mixture7 z well z ,s9k9a1 & 0 unable to note any diff]5ces betwe5 !m4 ,,?ird ,,inve/igation ,! ?ird inve/igator began ! trial ( ,s9k9a at ! in/ance ( ! manufactur]s1 & us$ x 9 ?ree cases1 two ( !m be+ b5ign t]tian mal>ia & "o case ( mix$ infection 7b5ign t]tian & e/ivo-autumnal74 ,,case #f4--,?is 0 "o ( ! cases ( b5ign t]tian mal>ia4 ,! pati5t gave a cl9ical hi/ory ( mal>ia ) *ills occurr+ on alt]nate days = a little ov] a week4 ,!re 0 an imm$iate cessation ( all cl9ical symptoms1 & ?ree days aft] ! pati5t _h be5 on #a_/b ounce ( ,s9k9a ?ree times daily !re 0 no evid5ce ( any plasmodia 9 8 blood2 8 additional treatm5t consi/$ ( #e gra9s ( calomel ! ev5+ ( ! fir/ day ) a sal9e ! next morn+4 ,be=e ! pati5t 0 put on treatm5t1 num]\s p>asites ( bo? ! asexual & sexual =ms 7 obs]v$4 ,! pati5t rema9$ 9 b$ = a few days1 & !n return$ to "w4 ,a week lat] he 0 aga9 tak5 ill ) a return ( all ( 8 previ\s cl9ical symptoms4 ,,case #g4--,?is case 0 "o ( mix$ infection 7b5ign t]tian & e/ivo-autumnal74 ,! pati5t _h a cl9ical hi/ory ( mal>ia dat+ back two weeks1 ) a maximum temp]ature ( #ajd on admission4 ,t]tian r+s1 e/ivo-autumnal r+s & cresc5ts 7 f\nd 9 ! blood4 ,! pati5t 0 plac$ 9 b$1 giv5 ?or\gh elim9at+ treatm5t1 & #a_/b ounce ( ,s9k9a 0 adm9i/]$ f\r times daily4 ,8 cl9ical symptoms ran on = two days ) no *ange1 & !re 0 no difficulty 9 f9d+ ! plasmodia 9 blood-sme>s1 :i* 7 tak5 twice daily4 ,! dose 0 !n d\bl$ & at ! end ( f\r days m !re 0 no *ange 9 ei!r 8 cl9ical symptoms or ! blood-f9d+s4 ,! pati5t 0 !n plac$ on #aj gra9s ( qu99 sulphate ) #ae drops ( dilut$ hydro*loric acid ?ree times daily1 to :i* he respond$ 9 less ?an =ty-eight h\rs & made an unev5tful recov]y4 ,,case #h4--,?is 0 ! o!r case ( b5ign t]tian mal>ia4 ,! pati5t _h *ills e o!r day :ile on ! treatm5t1 & laboratory diagnosis confirm$ ! cl9ical f9d+s4 ,exp]im5tal treatm5t 0 c>ri$ on = f\r days1 ) a negative result4 ,! inve/igator calls att5tion to ! fact t ! fir/ case 9 :i* improvem5t result$ does n %[ any necess>y connection ) ! ,s9k9a adm9i/]$1 = _m cases ( b5ign t]tian mal>ia w cle> up 9 j z %ort a "t "u any l9e ( treatm5t1 :ile practically all w ev5tually d s4 ,?is inve/igator lat] report$ ano!r case & transmitt$ a cl9ical *>t4 ,,case #i4--,?is pati5t 0 admitt$ to ! hospital1 ,dec4 #cj1 #aiab1 ) a hi/ory ( hav+ _h mal>ia = "s weeks4 ,! diagnosis 0 confirm$ by a blood exam9ation4 ,he 0 !n c>ri$ = f\r days )\t treatm5t o!r ?an re/ 9 b$ & a liquid diet4 ,8 symptoms subsid$ by ! ?ird day4 ,on ! f\r? day a c\nt ( ! p>asites 0 made :i* %[$ t !re 7 #a1afj asexual p>asites & #bfj sexual =ms to e ?\s& leukocytes4 ,! foll[+ day he 0 plac$ on ,s9k9a1 #a ounce ?ree times daily4 ,!re 0 exac]bation ( symptoms on ! foll[+ day1 :i* gradually increas$ until ! f\r? day1 rema9+ ab\t /ation>y = a day or s4 ,! fif? day aft] ! pati5t _h be5 plac$ on ,s9k9a1 ano!r c\nt ( ! p>asites %[$ #e1fjj asexual p>asites & #cjj sexual =ms to ! ?\s& leukocytes1 ?is be+ an increase ( #d1ddj asexual =ms & =ty sexual =ms to e ?\s& leukocytes4 ,) ! second c\nt ( p>asites ! dose ( ,s9k9a 0 increas$ to #b ounces e f\r h\rs1 ! pati5t be+ kept on ?is until ,janu>y #ad1 )\t result4 ,he 0 !n plac$ on qu991 ) a complete r$uction ( ! temp]ature to normal & ! disappe>ance ( ! p>asites f ! blood4 ,! inve/igator also report$ a case ( b5ign t]tian mal>ia4 ,,case #aj4--,?is 0 9 a *ild ( #h ye>s :i* 0 treat$ by ! inve/igator's confrre & gave simil> negative results4 ,blood exam9ation %[$ num]\s p>asites4 ,! *ild 0 plac$ on #a ounce ( ,s9k9a ?ree times a day & kept on x = two weeks4 ,! cl9ical picture rema9$ unalt]$1 & p>asites c\ld be detect$ 9 numb]s :5ev] exam9ations 7 conduct$4 ,a gradually increas+ enl>gem5t ( ! sple5 0 also not$4 ,at ! end ( two weeks qu99 0 sub/itut$1 & ! *ild w5t on to a rapid & unev5tful recov]y4 ,?is inve/igator also concludes t ! claim put =? by ! ,metropolitan ,ph>macal ,company t ,s9k9a is a specific 9 ! treatm5t ( ! mal>ial fev]s is entirely )\t f\ndation1 & t ! firm w be unable to demon/rate to ! contr>y4 ,^! inve/igations demon/rate t ,s9k9a is n a specific aga9/ mal>ia1 & t x has no m effect ?an a mixture ( oil ( cum91 sug>1 alcohol & wat]4 ,!y fur!r %[ ! fallacy1 fir/1 ( conclud+ f a tempor>y cessation ( ! symptoms 9 mal>ia t ! disease has be5 cur$ &1 second1 ( ascrib+ su* tempor>y improvem5t to ! influ5ce ( a rem$y :i* has no kn[n effect on ! mal>ial organism4--7,f ! ,j\rnal ,a4 ,m4 ,a41 ,sept4 #bg1 #aiac47 ,,somnos ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,to ! ,c\ncil on ,ph>macy & ,*emi/ry ( ! ,am]ican ,m$ical ,association3--,y\r subcommittee1 to :om 0 assign$ ,somnos1 ,h4 ,k4 ,mul=d ,company1 submits ! foll[+ report ( exp]im5ts1 und]tak5 to comp>e ! effects ( ,somnos ) ^? ( *loral hydrate4 ,^! exp]im5ts demon/rate t ! /atem5ts made 9 reg>d to ! action ( ,somnos are 9 conflict ) ,rule #f ( ! ,c\ncil1 :i* requires3 8,no article w be admitt$ or reta9$ conc]n+ :i* ! manufactur] or 8 ag5ts make unw>rant$1 exagg]at$ or mislead+ /atem5ts z to ! !rapeutic value40 ,x is1 !re=e1 recomm5d$ t ,somnos be n approv$ = inclusion 9 ! book until ! claims made = x are correct$4 ,x is also recomm5d$ t ! report be publi%$3 ,! ,ph>macology ( ,somnos ,:5 ^! exp]im5ts 7 begun1 ,april1 #aijf1 !re 0 no?+ 9 ! adv]tis+ lit]ature on ,somnos to indicate :e!r ?is article is a solution or a pure sub/ance4 ,on ! label on ! bottle1 9 ! circul> accompany+ ! bottle1 & 9 ! booklet 8,somnos10 ! ^w ,somnos seem$ to be us$ z a synonym ( 8,*ore?anal alcoholate10 ,c#i;,h#aa,o#e;,cl#i1 & physicians 7 prescrib+ & ph>maci/s disp5s+ x 9 ! belief t x 0 a pure sub/ance4 8,! pure sub/ance2 "s k9d ( an alcohol2 no?+ to d ) *oral10 0 ! way ! druggi/ f :om ! samples 7 pur*as$ put x4 ,?us in=mation absolutely indisp5sable = any rational comp>ison ( ,somnos ) o!r hypnotics 0 )held f ! physician4#hf #hf ,two weeks ago 7,j\rnal ,a4 ,m4 ,a41 ,sept4 #a1 #aijf1 p4 #fie7 x 0 po9t$ out t ! manufactur]s n[ give ?is in=mation1 b 9 a :olly unnecess>ily obscure =m4 ,h5ce1 be=e beg9n+ ! physiologic exp]im5ts x 0 necess>y to det]m9e ! /r5g? ( ! prep>ation2 = ?is purpose ?ree *lor9 det]m9ations 7by ! ,c>ius me?od7 7 made4 ,on ! assumption t all ! *lor9 pres5t 0 9 comb9ation z *loral glyc]ate1 ,c#c;,h#e;,c,cl#c4;,c7,,oh7#bc ,c#i;,h#aa,o#f;,cl#i1 & calculat+ ! p]c5tage ( ?is 9 ,somnos1 ! foll[+ results 7 obta9$3 7#a7 #e4aa p] c5t42 7#b7 #e4ae p] c5t42 7#c7 #e4aj p] c5t4 ,somnos1 !re=e1 0 f\nd to conta9 approximately #e p] c5t4 ( *loral glyc]ate & its physiologic action 0 comp>$ ) t ( a #e p] c5t4 solution ( hydrat$ *loral4 ,9 "s exp]im5ts ! hydrat$ *loral 0 dissolv$ 9 wat]2 9 o!rs1 9 #aj p] c5t4 alcohol 7,somnos 0 f\nd to conta9 at ?is "t ab\t ?is p]c5tage ( alcohol72 9 o!r exp]im5ts glyc]9 0 add$1 z ,somnos 0 f\nd to conta9 ?is sub/ance4 ,no v m>k$ diff]5ces 7 f\nd 9 ! physiologic action ( ! ?ree solutions4 ,,fatal ,,dose ,,( ,,somnos ,,= ,,! ,,l[] ,,animals ,! booklet on ,somnos /ates t 8,somnos has no toxicology02 t :ile *loral hydrate causes 8acute poison+10 8deep coma10 etc41 ,somnos is 8h>mless 9 tw5ty times ! dose prescrib$10 8coma unkn[n1 etc40 ,! physician w\ld sc>cely suspect f su* /atem5ts t ,somnos is z poison\s a sub/ance z solutions conta9+ hydrat$ *loral 9 correspond+ am\nt2 t su* is ! case is %[n by ! foll[+ exp]im5ts4 ,^! exp]im5ts 7 necess>ily made on ! l[] animals4 ,:ile su* results d n enable u to draw v def9ite conclusions z to ! absolute toxicity ( poison = man1 ! results on animals are conclusive z reg>ds ! relative toxicity = man ( su* closely relat$ drugs z hydrat$ *loral & ,somnos4#hg #hg ,t portion ( ! report describ+ ! exp]im5ts on animals is "h omitt$4 ,x 0 pr9t$ 9 full 9 ,! ,j\rnal & 9 ! ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry1 #aije-aijh4 99 99 99 99 99 ,,conclusions ,to sum up our results on ! physiologic action ( ,somnos3 ,we h be5 completely unable to v]ify ! claims ( ! manufactur]s t ,somnos is less toxic ?an hydrat$ *loral1 or t x has a less depress+ effect on temp]ature1 respiration or circulation4 ,on ! contr>y1 ! physiologic effects are indi/+ui%able f ^? ( hydrat$ *loral1 d\btless because ! action ( ,somnos is simply ! action ( hydrat$ *loral4 ,we c see no?+ 9 ! animal exp]im5ts or 9 ! *emical composition :i* w\ld sugge/ t ,somnos w\ld possess !rapeutic advantages ov] an elixir ( hydrat$ *loral ( correspond+ /r5g?4#hh ,x is to be hop$ t physicians :o h be5 bl9dly us+ ,somnos )\t ev5 kn[+ ! /r5g? ( ! prep>ation1 mu* less :at x is1 w comp>e its effects ) ^? ( a #e p] c5t4 elixir ( hydrat$ *loral4#hh--7;,abbreviat$ f ,! ,j\rnal ,a4 ,m4 ,a41 ,sept4 #ae1 #aijf47 #hh ,! booklet on ,somnos1 8,somnos1 a ,ph>macological ,report10 :i* is ref]r$ to "h1 conta9s a 8,!rapeutic ,index to ! ,usefulness ( ,somnos40 ,we give bel[ a li/ ( diseases m5tion$ 9 ?is index to %[ ! wide range ( usefulness 787 t is claim$ = ?is *loral comp\nd4 ,abortions4 ,abscess--( bra91 kidney1 liv]1 tonsils1 p>otid gl&1 m$ia/9um2 9 app5dicitis1 gl&]s1 p]9ephritic1 retroph>yngeal1 pyemic1 pelvic1 ov>ian4 ,somnos less5s pa9 & quiets n]v\s /ate4 ,tablespoonful1 repeat$ once or twice4 ,use lib]ally4 ,alcoholism--full doses repeat$ (t54 ,gives calm sleep4 ,no blood *anges l ^? produc$ by *loral4 ,anemias--progressive & second>y4 ,somnos has no delet]i\s action on blood z is common ) o!r hypnotics4 ,aneurism4 ,ang9a4 ,apoplexy4 ,app5dicitis4 ,ar?ritis4 ,ars5ical poison+4 ,art]ioscl]osis4 ,a/hma4 ,bili>y colic1 ,bright's disease4 ,c>buncle4 ,c>c9oma4 ,cat>rh4 ,cellulitis4 ,c]ebrosp9al fev]4 ,*lorosis4 ,*olecy/itis4 ,*ordee4 ,*orea4 ,cirrhosis4 ,coccydynia4 ,colic4 ,colitis4 ,concussion4 ,confusional ,insanity4 ,contusions4 ,convulsions4 ,coryza4 ,c\gh4 ,cramps4 ,cy/itis4 ,delirium4 ,diabetes4 ,di>rhea4 ,diph!ria4 ,dropsy4 ,dysm5orrhea4 ,dyspnea4 ,e>4 ,emphysema4 ,empyema4 ,endoc>ditis4 ,endometritis4 ,epididymitis4 ,epilepsy4 ,erysipelas4 ,fev]s4 ,fi/ula4 ,gall/ones4 ,ga/ralgia or ,ga/rodynia4 ,ga/ritis4 ,gonorrhea4 ,goit]4 ,g\t4 ,halluc9ations4 ,hay fev]4 ,heada*e4 ,he>t ,disease4 ,hemicrania4 ,hicc\gh4 ,hydronephrosis4 ,hydrophobia1 ,hydro?orax4 ,hyp]e/hesia4 ,hy/]ia4 ,indige/ion4 ,inflammation4 ,insomnia4 ,kidney disease4 ,l>yngitis4 ,liv] abscess4 ,cirrhosis4 ,lob> pneumonia4 ,lockjaw4 ,locomotor ataxia4 ,lumbago4 ,mal de m]e4 ,mal>ial fev]4 ,m5+itis4 ,migra9e4 ,melan*olia4 ,metritis4 ,morph9ism4 ,muscul> rheumatism4 ,myelitis4 ,myoc>ditis4 ,myositis4 ,nephritis4 ,n]v\s dyspepsia4 ,neuralgia1 occipito-c]vical1 etc4 ,neura/h5ia4 ,neuritis4 ,night sweats4 ,or*itis4 ,otitis m$ia4 ,p>e!sia4 ,p>alysis4 ,p>otitis4 ,peliosis rheumatica4 ,p]ic>ditis4 ,p]imetritis4 ,p]ihepatitis4 ,p]i*ondritis4 ,p]itonitis4 ,p]tussis4 ,petit mal4 ,ph>yngitis4 ,ph?isis4 ,pleurisy4 ,pneumonia4 ,po/-epilepsy4 ,prolaps$ ut]us4 ,pseudo ang9a pectoris4 ,purpura4 ,rabies4 ,rheumatic fev]4 ,salp+itis4 ,s>coma4 ,sc>let fev]4 ,smallpox4 ,spasms4 ,/oma*4 ,/omatitis4 ,sun/roke4 ,t5esmus4 ,tetanus4 ,tonsillitis4 ,trauma4 ,trismus4 ,typhoid fev]4 ,typhus fev]4 ,ulc]s4 ,urtic>ia4 ,v>icella4 ,vomit+4 ,vulvitis4 ,yell[ fev]4 ,,succus ,,alt]ans ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! foll[+ report 0 adopt$ by ! ,c\ncil3 ,x is1 believ$ t unw>rant$ & exagg]at$ !rapeutic claims are made = ,succus ,alt]ans by its manufactur]s1 ,eli ,lilly ,co41 ,indianapolis4 ,9 view ( ! disa/r\s results :i* may foll[1 if1 f ! /atem5ts made1 physicians %\ld be l$ to rely on ! product z a treatm5t = syphilis1 x is recomm5d$ t ,succus ,alt]ans be refus$ recognition & t ?is fact be publi%$ ) comm5ts4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,comm5t3 ,succus ,alt]ans is a prep>ation :i* has be5 put on ! m>ket = "s ye>s by ,eli ,lilly ,co41 z a rem$y = syphilis4 ,! s]i\s "* ( ?is disease & especially ! deplorable results t ensue f its improp] or insuffici5t treatm5t1 %\ld make a firm hesitate to advise any treatm5t = x :i* exp]i5ce has n demon/rat$ to be at lea/ z efficaci\s z t :i* is g5]ally accept$ & well prov$4 ,succus ,alt]ans is ! result ( a comb9ation ( circum/ances2 no "o p]son is responsible = x4 ,x 0 probably ! natural desire = a rem$y free f ! occasional injuri\s results ( m]cury t l$ ,dr4 ,j4 ,m>ion ,sims to advocate ! use ( a collection ( indig5\s ,am]ican plant drugs1 s>sap>illa1 /ill+ia1 xan?oxylum1 etc41 :i* _h a local reputation = ! cure ( syphilis4 ,^! drugs are suppos$ to be in]t :5 ! dri$ plants 7 us$1 & ?is gave an opportunity = ! developm5t ( a no/rum4 ,! +r$i5ts are well kn[n1 b z _! virtues are suppos$ to be lo/ 9 dry+1 ! physician c n h 8 druggi/ comp\nd !m1 b mu/1 p]=ce1 prescribe ! propriet>y comb9ation4 ,^? :o cons5t$ to exp]im5t ) ! new rem$y soon f\nd t ! claims to curative prop]ties 7 unf\nd$1 b ! /rong comm]cial int]e/s back+ x h prolong$ its life to ! pres5t "t4 ,au?orities on syphilis ei!r say no?+ ab\t ! prep>ation or m5tion x m]ely to condemn2 b ! proprietors ( ! no/rum cont9ue to ass]t t x is n only practically a specific 9 syphilis1 b n[ recomm5d x = v>i\s d]angem5ts ( ! blood & all sorts ( sk9 diseases4 ,?is be+ ! case1 :at %all ! wise physician d8 ,%all he bl9dly foll[ an au?ority ( a pa/ g5]ation or %all he recognize t ! claims ( an int]e/$ manufactur] ought n to weigh aga9/ ! cons5sus ( 8 pres5t-day confrres :o h giv5 ! treatm5t ( syphilis _! special att5tion8 ,! exploitation ( su* a prep>ation is des]v+ ( /rong c5sure4 ,by su* me?ods ! firm places itself on ! same plane z ^? no/rum v5d]s1 :o adv]tise c]ta9 antiseptic sprays & g>gles z cures = epidemic m5+itis & diph!ria & !reby deprive cr$ul\s victims ( ! curative antitox9 treatm5t4 ,succus ,alt]ans is n a new rem$y on trial = its possibilities ( improvem5t 9 !rapeutics2 x is an old mixture :i* has be5 tri$ & f\nd want+4--7,f ! ,j\rnal ,a4 ,m4 ,a41 ,june #bf1 #aiji47 ,,sulpho-,,ly?9 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,sulpho-,ly?9 is sold by ! ,la9e ,*emical ,company1 ,new ,york4 ,9 ! lit]ature s5t to physicians x is said3 8,?is product1 ! sulpho-phosphite ( sodium & li?ium 7non-eff]vesc5t71 is entirely new & is unique 9 its action40 ,*emical analysis ( a specim5 ( ,sulpho-,ly?9 pur*as$ 9 ! op5 m>ket indicat$ its composition to be3 ,sodium sulphate1 anhydr\s #aj4ea ,disodium hydrog5 phosphate1 anhydr\s #ef4fg ,sodium ?iosulphate1 anhydr\s #bj4gh ,sodium *lorid #e4ih ,li?ium1 z citrate #c4ab ,sulphur1 free #j4af ,moi/ure #a4ec ,loss #a4be ,! exam9ation1 !re=e1 %[s t ,sulpho-,ly?9 is a mixture consi/+ ma9ly ( sodium sulphate & sodium phosphate & sodium ?iosulphate4 ,! /atem5t t x is a 8sulpho-phosphite ( sodium & li?ium10 !re=e1 is n correct1 & a /atem5t t 8x is entirely new & unique 9 its action0 appe>s unw>rant$ & mislead+4 ,x is1 !re=e1 recomm5d$ t ! prep>ation be refus$ recognition4 ,x is also recomm5d$ t an article be prep>$ = publication call+ att5tion to ! exagg]at$ claims made = ,sulpho-,ly?94 ,! recomm5dations ( ! subcommittee 7 adopt$ by ! ,c\ncil & 9 accordance !re) ! report is publi%$ ) comm5ts1 sub/antially z foll[s3 ,! =mula means t x is a solution ( well-kn[n salts1 "s ( !m "u p>tially disguis$ names4 ,e "o kn[s :at ,glaub]'s salts are good =4 ,disodium hydrog5 phosphate is ord9>y common sodium phosphate4 ,sodium ?iosulphate is famili> z sodium hyposulphite1 ! 8hypo0 ( ! photograph]s4 ,e "o kn[s1 ( c\rse1 t sodium *lorid is common salt4 ,exam9ation & analysis ( v>i\s specim5s ( ?is product demon/rat$ t its composition is n always ! same4 ,z an indication ( ! ignorance ( ! promot]s ( ?is no/rum x is int]e/+ to note t ! label on "o ( ! bottles pur*as$ /ates t x is a 8sulphophosphate0 in/ead ( a sulphophosphite4 ,extravagant claims are made = ?is simple mixture ( laxative salts1 & ^! ) ! me?ods ( us+ x are pr9t$ on ! labels1 & :ile x is claim$ to be only adv]tis$ to ! pr(ession1 ! physician is repeat$ly advis$ 9 ! adv]tisem5ts to 8ord] always an orig9al 7six ounce7 bottle to prev5t sub/itution40 ,! natural result ( ?is w\ld be1 ( c\rse1 to put ! pati5t 9 ! way ( prescrib+ x = himself & to spread ! adv]tisem5t ( ! drug among ! public4 ,difficulty has be5 exp]i5c$ 9 f9d+ out :o ! promot]s ( ?is no/rum are & ! correspond5ce 9 reg>d to x is publi%$4 ,!y seem to pref] to be kn[n by _! corporate title ( ,la9e ,*emical ,company only4 ,x is a sample ( _m o!r s-call$ e?ical propriet>y drugs1 mo/ ( :i* are simple mixtures ( well-kn[n drugs :i* physicians are us+ e day & :i* require no skill 9 _! comp\nd+4 ,_! proprietors n only presume to sell & adv]tise m$ic9es b also to tell ! physicians h[ to treat _! pati5ts4--7,ab/ract$ f ,! ,j\rnal ,a4 ,m4 ,a41 ,dec4 #h1 #aijf47 ,,taurocol ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,paul ,plessn] ,company1 ,detroit1 places on ! m>ket ,taurocol ,tablets & ,taurocol ,comp\nd ,tablets4 ,! company makes a pret5se ( giv+ ! =mula--m9us any quantities--?us3 8,taurocol is a comb9ation ( bile salts1 extracts ( casc>a sagrada1 ph5olph?ale9 & aromatics40 ,! 8=mula0 giv5 = ,taurocol ,comp\nd ,tablets is3 8,taurocol 7,bile ,salts7 ,gramme 4#abif ,peps9 #a-cjjj 4#jcbd ,pancreatic ,ext 4#jcbd ,extract ,nux ,vomica 7#a_/h gr47 4#jjha ,aromatics ,q4 ,s40 ,a comp>ison ( ^! two 8=mulas0 ) ^? furni%$ = ,v]acolate & ,v]acolate ) ,pancreat9 & ,peps9 %[s t !y are ne>ly ! same4 ,! claims made = ! ,taurocol prep>ations are ess5tially ^? made = ,v]acolate prep>ations1 z in/ance ! foll[+1 :i* appe>s on a physician's sample ( ,taurocol3 8,= ,hepatic ,insuffici5cy1 ,inte/9al ,putrefaction1 ,habitual ,con/ipation40 ,likewise ! foll[+1 f\nd on a ,taurocol circul>1 duplicates claims made = ,v]acolate3 8444 ,directly /imulates ! liv] cells1 produc+ an abundant fl[ ( bile ri* 9 *olates1 solv5t ( *ole/]9 & a bili>y antiseptic40 ,taurocol is objectionable = ! reasons t apply to ,v]acolate1 & ,taurocol ,comp\nd ,tablets are subject to ! objections t apply to ,v]acolate ) ,peps9 & ,pancreat94 7,see p4 #baf47 ,! ,c\ncil !re=e refus$ recognition to ,taurocol & its prep>ations4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,april #bd1 #aiae47 ,,tri-,,iodides1 ,,?ree ,,*lorides ,,& ,,maizo-,,li?ium ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,z an illu/ration ( unreliability ( claims & ! unsci5tific "* ( propriet>y mixtures1 ! ,c\ncil has au?oriz$ publication ( ! foll[+ reports on ,tri-,iodides1 ,?ree ,*lorides & ,maizo-,li?ium1 products ( ! ,h5ry ,ph>macal ,co4 7,j4 ,f4 ,ball>d1 proprietor74 ,w4 ,a4 ,puckn]1 ,secret>y4 ,tri-,iodides 7,h5ry7 ,tri-,iodides 7,h5ry ,ph>macal ,co41 ,/4 ,l\is7 is a no/rum ^: +r$i5ts app>5tly 7 select$ at r&om4 ,s9ce ! effects ( su* a mixture _c be pr$ict$1 no ?\ghtful physician w\ld ?9k ( prescrib+ 9 any "o condition all ! drugs nam$ 9 ! =mula ( ,tri-,iodides--if he _h to write out ! prescription4 ,yet because ! mislead+ "n ( ! prep>ation gives x ! semblance ( a !rapeutic entity--& because x is adv]tis$ 9 m$ical j\rnals--a c]ta9 numb] ( physicians ?\ghtlessly prescribe ?is %otgun mixture4 ,,laboratory ,,report ,reg>d+ ! composition ( 8,tri-,iodides0 ! ,association's ,*emical ,laboratory makes ! foll[+ report3 ,a trade package ( ,h5ry's ,tri-,iodides pur*as$ 9 #aiaj bore ! foll[+ =mula on ! label3 8,col*ic91 #a-bj gra91 8,phytolacc91 #a-aj gra91 8,solan91 #a-c gra91 8,sodium ,salicylate1 ,c4 ,p41 #aj gra9s1 8,iodic ,acid 7equal to #g_/cb gr4 ( ,iod9e7 9 two fluid dra*ms ( ,aromatic ,cordial40 ,9 ! circul> :i* 0 wrapp$ ) ! bottle ! word+ ( ! =mula diff]s some:at f ! =ego+1 8iodic acid0 ( ! label be+ replac$ by 8hydro-iodic acid40 ,:ile ! label on ! bottle nam$ 8phytolacc90 z "o ( ! con/itu5ts ! label on ! c>ton :i* conta9$ ! bottle gave 8dec&r940 ,! foll[+ =mula appe>s on a trade package pur*as$ ,june1 #aiad3 8,col*ic9e1 #a-bjj ,gra91 8,phytolacca1 #a #a-e ,gra91 8,mydriatic ,alkaloids1 #a-ejj ,gra94 8,sodium ,salicylate1 #c #a-b ,gra94 8,iodic ,acid 7equal to #g-abe ,gra9 ( ,iod9e7 9 two fluid dra*ms40 ,! diff]5ces betwe5 ! =mulas are /rik+4 ,col*ic9 has be5 r$uc$ f #a_/bj gra9 to #a_/bjj gra92 sodium salicylate f #aj gra9s to #c-a_/b gra9s2 iod9 7claim$ to be pres5t z iodic acid7 f #g_/cb gra9 to #g_/abe gra94 8,phytolacc90 78,dec&r907 has be5 replac$ by 8,phytolacca0 & 8,solan90 by 8,mydriatic ,alkaloids40 ,:ile ! =mula = ! prep>ation has be5 *ang$1 ! circul> accompany+ ! package /ill ref]s to 8solan90 79 "s p>ts ( ! circul> wrongly spell$ 8salon907 & 8phytolacc940 ,z no pr9ciple hav+ ! *>act]i/ic effects ( poke-root is kn[n to h be5 isolat$ ! t]ms 8dec&r90 & 8phytolacc90 are mean+less4 ,! circul> /ates t solan9 is an alkaloid obta9$ f ! spr\ts ( ,solanum tub]osum1 b wrongly calls ?is plant 8bitt]sweet0 in/ead ( potato4 ,at ! m>ket price ! am\nt ( solan9 claim$1 accord+ to ! old =mula1 to be pres5t 9 a bottle ( ,tri-,iodides1 w\ld co/ #a4fj1 al?\gh a bottle ( ! prep>ation sold at :olesale = #fg c5ts4 ,tri-,iodides is a d>k br[n1 mobile liquid hav+ a fa9t clove-l odor & a mawki%1 sweet ta/e4 ,salicylate 0 f\nd 9 consid]able am\nts4 ,traces ( alkaloids 7 f\nd1 a portion ( :i* appe>$ to be col*ic94 ,iodic acid & its salts 7 abs5t1 al?\gh claim$ by ! =mula to be pres5t4 ,potassium iodid 0 pres5t4 ,det]m9ations ( ! iod9 by di/illation ) f]ric ammonium sulphate solution & sulphuric acid indicat$ ! pres5ce ( ab\t #a4fh gm4 ( iod9 7equival5t to #b4ah gm4 ( potassium iodid7 9 ea* #ajj c4c4 ( ! prep>ation4 ,?is is equival5t to ab\t #g4fe gra9s ( iod9 p] fluid\nce1 or m ?an ?irty-f\r times ! am\nt claim$ by ! =mula on ! bottle4 ,an approximate det]m9ation ( ! salicylic acid by extraction ( ! acidifi$ prep>ation ) e!r & evaporation ( ! solv5t indicat$ ab\t #b4fg gm4 9 #ajj c4c41 equival5t to #c4ji gm4 ( sodium salicylate1 or ab\t #ad4aa gra9s p] fluid\nce4 ,s9ce ! am\nt ( sodium salicylate claim$ is #c4e gra9s 9 #b fluidrams or #ad gra9s 9 ea* fluid\nce1 ! am\nt f\nd agrees ess5tially ) ! claims4 ,,absurd ,,claims ,x %\ld be unnecess>y1 aft] po9t+ out ! conflict betwe5 ! "n & ! publi%$ =mula1 betwe5 ! =mula & ! actual composition1 & betwe5 ! composition & all e/abli%$ !rapy1 to discuss ?is het]og5e\s & unsci5tific mixture fur!r4 ,a few specim5 absurdities1 h[ev]1 may be quot$ f ! adv]tis+ 8lit]ature03 8444 ,free ( ! ,disagreeable ,effects ( ! ,alkal9e ,iodides40 ,tri-,iodides1 accord+ to ! laboratory report1 dep5ds = its iod9 action on potassium iodid4 8444 we h an assimilable =m ( vegetable hydriodates4 8,! hydriodates ( ^! valuable vegetable alkaloids af=d ! specific alt]ative action ( iod9e )\t su* disagreeable results z ! iodism produc$ by ! ord9>y iodides40 8,! hydriodates0 is an obsolete t]m =m]ly appli$ to iodids ( vegetable alkaloids4 ,iodids ( vegetable alkaloids1 if pres5t at all 9 ,tri-,iodides1 are pres5t 9 negligible am\nts4 8,conta9+ ,iod9e 9 an available =m1 x is obvi\s t ! =mula mu/ be b5eficial 9 ! majority ( syphilitic sk9 lesions40 ,! falsity ( ! fir/ two ( ^! claims & ! mis*iev\sness ( ! la/ are self-evid5t4 ,x w\ld be possible1 b is unnecess>y1 to produce an almo/ unlimit$ am\nt ( evid5ce to %[ ! transp>5t "* ( ! deception by :i* ?is prep>ation is exploit$4 ,! ref]ee feels t ! no/rum w h be5 suffici5tly *>act]iz$ :5 he has m5tion$ fur!r t ! "n 8,h5ry's ,tri-,iodides0 is bl[n 9 ! glass ( ! bottle1 t ! label conta9s ! recomm5dation 8,= ,g\t1 ,rheumatism & o!r ,dia!tic ,diseases10 & t ! circul> accompany+ ! bottle recomm5ds ! use n only ( ,tri-,iodides1 b also ( ,?ree ,*lorides1 ,maizo-,li?ium1 ,campho-,ph5ique & ,satyria 9 ! treatm5t ( _m diseases4 ,?ree ,*lorides 7,h5ry7 ,?ree ,*lorides 7,h5ry7 is adv]tis$ z3 8,an oxyg5-c>ry+ f]rug9\s prep>ation1 suitable = prolong$ treatm5t ( *ildr51 adults & ! ag$4 ,indicat$ 9 anemia & convalesc5ce f acute diseases & surgical op]ations40 ,! foll[+ report on ! composition ( ,?ree ,*lorides is submitt$ by ! ,association's ,*emical ,laboratory3 ,,laboratory ,,report ,x is claim$ t ea* fluidram ( ,h5ry's ,?ree ,*lorides conta9s3 8,m]curic ,bi*lorid #a-gb ,gr4 8,ars5ic ,*loride #a-dj ,gr4 8,proto-,*loride ,iron #b-be ,gr4 8 444 9 a cordial ( ,calisaya ,alkaloids40 ,! prep>ation is a pale yell[1 cle> solution hav+ an odor ( alcohol4 ,! addition ( potassium f]ricyanid solution does n produce any blue coloration1 ?us demon/rat+ ! abs5ce ( f]r\s *lorid 7iron proto*lorid74 ,in/ead potassium f]rocyanid solution produces at once an int5se blue precipitate & potassium sulphocyanate solution an int5se r$ coloration1 ?us prov+ ! pres5ce ( iron 9 ! f]ric condition4 ,x is obvi\s t ! claim$ sup]iority ( ,?ree ,*lorides ov] prep>ations conta9+ f]ric iron is absurd4 ,s9ce x conta9s iron 9 ! f]ric condition1 ,?ree ,*lorides decomposes soluble iodids ) ! lib]ation ( free iod94 ,! ass]tion t x is a suitable 8vehicle0 = ! adm9i/ration ( iodids is likely to lead ! physician unwitt+ly to adm9i/] free iod94 ,z ! laboratory report %[s1 ! 8=mula0 ( ,?ree ,*lorides 7,h5ry7 is incorrect1 = proto*lorid ( iron 7f]r\s *lorid7 0 abs5t f ! prep>ation4 ,!re is1 h[ev]1 a m s]i\s objection to ! =mula ?an ! mis/atem5t ( fact4 ,:5 ! physician is deal+ ) conditions t call = m]cury1 ars5ic or iron1 x is irrational & unsci5tific to prescribe a prep>ation conta9+ ^! ?ree drugs 9 fix$ proportions4 ,,objectionable ,,adv]tis+ ,?ree ,*lorides is m>ket$ 9 bottles hav+ ! "n 8,?ree ,*lorides0 bl[n 9 ! glass1 9 a c>ton conta9+ a circul> extoll+ ! curative p[]s ( ?is & o!r propriet>ies ( ! same conc]n4 ,?us a physician :o prescribes ,?ree ,*lorides is likely to place 9 ! h&s ( 8 pati5t ! advice t 8,?ree ,*lorides 444 is suitable = ! prolong$ treatm5t ( *ildr5 4440 8,9 t]ti>y syphilis1 ) or )\t potassium iodide1 x holds fir/ rank among rem$ies direct$ aga9/ ! specific ta9t 4440 ,fur!r1 t 8,maizo-,li?ium0 is3 8,a ,g5ito-,ur9>y ,s$ative0 & a 8rem>kable uric-acid solv5t40 ,also t 8,satyria0 is3 8,an ,ideal ,g5ito ,tonic & ,n]ve ,recon/itu5t40 8,indicat$ 9 ,pro/atic tr\ble1 ,cy/itis1 ,ure?ritis1 ,gonorrhea1 ,gleet1 ,leucorrhea1 ,sexual ,debility & ,impot5ce40 ,we are told t 8,z a hemat9ic1 ! proto*loride ( iron ju/ifies ! confid5ce ( ! m$ical pr(ession40 8,! proto*loride1 m ?an any o!r salt ( iron1 /imulates ! paptic sic & hydro*loric gl&ul> sy/em ( ! /oma*1 increas+ ! fl[ ( acid ga/ric juice40 ,x is unnecess>y to discuss ! tru? or falsity ( ^! ass]tions1 s9ce ,?ree ,*lorides does n conta9 ! proto*lorid ( iron4 ,= ! same reason1 x is obvi\s t ! small am\nt ( iron :i* x conta9s is ! only possible ju/ification = ! claim t ! prep>ation is 8444 ,non-,productive ( 444 ,con/ipation or ,tee? ,discoloration40 ,x is h>dly necess>y to po9t out t x is a !rapeutic exagg]ation to claim t ,?ree ,*lorides is ( p>ticul> value 9 ! treatm5t ( t]ti>y syphilis1 t 9 eczema x is 8! mo/ effective rem$y10 t 9 any =m ( con/ipation x is 8! rem$y p> excell5ce10 or t 8,aft] arre/+ mal>ial attacks ) qu99e1 ! comb9ation ( iron1 ars5ic & m]cury ) calisaya is an ess5tial requisite40 8,:5ev] ga/ric tr\bles & dige/ive di/urbances furni% a contra-indication to iron1 ?is contra-indication disappe>s :5 ! iron is comb9$ ) ars5ic40 8,! simultane\s exhibition ( small doses ( ars5ic & bi*loride ( m]cury1 besides augm5t+ ! effect ( iron ^u ! r$ blood-cells1 completely obviates ! t5d5cy to vascul> conge/ion & hemorrhage40 ,f9ally1 ! sugge/ion t by ! use ( ,?ree ,*lorides iodids may be prev5t$ f caus+ iodism is absurd4 ,9 %ort1 :atev] may be ! advisability ( prescrib+ iron1 ars5ic or m]cury 9 any giv5 case1 x is irrational to prescribe !m 9 fix$ proportions4 ,a physician :o is induc$ by ! exagg]at$ adv]tis+ claims to prescribe ^! drugs 9 a propriet>y mixture1 "u a non-in=mative "n1 does grave inju/ice to 8 pati5ts4 ,maizo-,li?ium ,maizo-,li?ium 7,h5ry ,ph>macal ,co41 ,/4 ,l\is7 is "o ( ! _m propriet>y li?ium prep>ations bas$ on ! disprov$ !ory t li?ium dissolves uric acid deposits 9 ! body4 ,! label on a trade package /ates t3 8,maizo-,li?ium promptly facilitates ! elim9ation ( ! uric & phosphatic deposits f ! sy/em40 ,z might be expect$1 ! promot] ( ,maizo-,li?ium ascribes a long li/ ( ills to 8uric & phosphatic deposits10 & argues t1 !re=e1 ,maizo-,li?ium is ! prop] treatm5t3 8,9 li!mia1 hematuria1 incipi5t diabetes1 cy/itis1 ure?ritis1 pyelitis & ,,all inflam$ conditions requir+ a non-irritat+ diuretic40 8,inflam$ conditions10 naturally1 include almo/ all ( ! real or imag9>y ills ( kidney1 bladd]1 etc4 ,maizo-,li?ium is di/+ui%$ f its cong5]s *iefly by ! claim t x conta9s a my?ical or problematical comp\nd1 maiz5ate ( li?ium4 ,,laboratory ,,report ,! foll[+ report on ! composition ( ,maizo-,li?ium has be5 submitt$ by ! ,*emical ,laboratory ( ! ,am]ican ,m$ical ,association3 ,! promot] ( ,maizo-,li?ium makes ! foll[+ /atem5t on ! label conc]n+ ! composition ( ! prep>ation3 8,ea* fluid dra*m conta9s two gra9s maiz5ate ( li?ium40 ,! foll[+ is also f\nd 9 a circul> :i* is enclos$ ) ! trade package ( ,maizo-,li?ium3 8,maizo-,li?ium1 ! rem>kable uric acid solv5t1 is a nasc5t *emic union ( maiz5ic acid1 obta9$ f gre5 corn silk1 ) ! alkal9e base li?ium =m+ maiz5ate li?ium1 ( :i* ! "m liquid c>ries two gra9s to ea* dra*m40 ,/&>d works on organic *emi/ry & ph>macology1 su* z ,beil/e9's ,organis*e ,*emie & ,cu%ny's ,ph>macology & ,!rapeutics1 d n m5tion maiz5ic acid4 ,nei!r is x m5tion$ 9 compreh5sive bibliographies ( phyto-*emical inve/igations1 su* z ,huseman-,hilg]'s ,die ,pflanz5/(fe or ,wehm]'s ,die ,pflanz5/(fe4 ,! fir/ to use ! t]m appe>s to h be5 a ,dr4 ,vauti] 7,ar*4 md4 belg471 b 8 publication is n available to ! laboratory4 ,radema*] & ,fis*] 7,am]4 ,j\r4 ,ph>m41 #ahhf1 lviii1 #cfi7 claim to h isolat$ ! sub/ance f gre5 corn-silk1 b ! record ( _! "w is unsatisfactory & indef9ite & !re=e _! results c\ld n be v]ifi$2 x seems unlikely1 h[ev]1 t !y isolat$ a pure proximate pr9ciple4 ,exam9ation ( ,maizo-,li?ium demon/rat$ ! abs5ce ( bromids1 *lorids1 phosphates1 sulphates1 acetates1 b5zoates1 salicylates & t>trates--comb9ations 9 :i* li?ium might be expect$ to be pres5t4 ,! pres5ce ( a citrate1 h[ev]1 0 %[n by ! usual te/s4 ,li?ium & sodium 7 pres5t4 ,free acid 0 abs5t4 ,det]m9ation ( li?ium citrate & ( sodium citrate indicat$ ! pres5ce ( a total ( ab\t #c4g gm4 ( ^! two salts 9 ea* #ajj c4c4 ( ! prep>ation1 or ab\t #b4a gra9s 9 ea* fluidram4 ,ab\t #be p] c5t4 ( ! total salts appe>$ to be li?ium citrate4 ,! exam9ation1 !re=e1 does n demon/rate ! pres5ce ( 8maiz5ate ( li?ium10 b does %[ t ,maizo-,li?ium conta9s a mixture ( li?ium citrate & sodium citrate4 ,te/s = citric acid & citrates 7 made on a comm]cial specim5 ( fluidextract ( corn-silk4 ,! results 7 negative1 al?\gh ! prep>ation _h an acid reaction to litmus4 ,! pres5ce ( maiz5ate ( li?ium 9 ,maizo-,li?ium--9 fact1 its actual exi/5ce--?us fail$ ( demon/ration4 ,9 view ( ?is fact1 x 0 felt t ! burd5 ( pro( re/$ on ! promot] ( ,maizo-,li?ium to supply "s satisfactory evid5ce ) reg>d to ?is sub/ance4 ,! foll[+ lett] 0 !re=e1 s5t to ,james ,f4 ,ball>d3 8,accord+ to ! label on a rec5tly pur*as$ bottle ( ,maizo-,li?ium1 ea* fluidram ( ?is prep>ation conta9s #b gra9s ( #8maiz5ate ( li?ium4' ,f an exam9ation made 9 ?is laboratory we are incl9$ to conclude t ?is /atem5t is n 9 accordance ) ! facts4 ,a se>* ( *emical & ph>maceutical publications does n reveal t su* a comp\nd z #8maiz5ate ( li?ium' has ev] be5 isolat$ & describ$1 & we are v mu* incl9$ to "q its exi/5ce4 ,we %\ld be pleas$ to receive f y any evid5ce :i* y may c>e to s5d 9 sub/antiation ( y\r claim 9 reg>d to ! cont5t ( #8maiz5ate ( li?ium' 9 ,maizo-,li?ium--p>ticul>ly a specim5 ( #8maiz5ate ( li?ium' or ! me?od by :i* x is produc$40 ,:ile ?is lett] 0 s5t ,oct4 #ac1 #aiad1 no evid5ce has be5 submitt$ up to date 7,janu>y1 #aiae7 to sub/antiate ! ass]t$ pres5ce ( maiz5ate ( li?ium 9 ,maizo-,li?ium4 ,! report j giv5 %[s t ! manufactur] has f\nd x exp$i5t to surr\nd 8 wor?less no/rum ) a cloak ( my/]y4 ,a discussion ( ! jumble ( uncritical claims1 baseless ass]tions & evid5t falsehoods pres5t$ 9 favor ( ,maizo-,li?ium w\ld seem a wa/e ( "t :5 ! secrecy ( ?is no/rum is all-suffici5t = its condemnation4 ,editorial ,note4--,:5 ! ,c\ncil on ,ph>macy & ,*emi/ry 0 />t$ we ann\nc$ t we did n see any cle> l9e ( dem>cation betwe5 8pat5t m$ic9es0 & _m s-call$ 8e?ical propriet>ies40 ,"t has n caus$ u to *ange our op9ion4 ,z we h already %[n1 & z we %all h occasion to %[ 9 ! future1 n a few ( ! 8e?ical propriet>ies0 (f]$ to physicians are be+ adv]tis$ by ^? :o are pu%+ ! ranke/ ( 8pat5t m$ic9es40 ,! ?ree prep>ations m5tion$ above are sold--& presumably manufactur$--by ,mr4 ,ball>d1 ( ,/4 ,l\is4 ,mr4 ,ball>d is ! promot] ( ,ball>d's ,sn[ ,l9im5t1 ,br[n's ,iron ,bitt]s1 ,h]b9e1 ,dr4 ,h]rick's ,vegetable ,liv] ,pills1 ,swaim's ,panacea1 ,r5ne's ,pa9 ,kill+ ,oil1 etc4 ,he is also ! promot] ( ,campho-,ph5ique1 expos$ 9 ,! ,j\rnal "s eight ye>s ago4#hi ,! spectacle is n an edify+ "o4 ,a manufactur] ) "o h& (f]s ! public a pr(usion ( cure-alls1 :ile ) ! o!r he endeavors to foi/ on ! m$ical pr(ession prep>ations :i* are j z fraudul5t4 ,"s day our pr(ession w awake to ! disgrace ( x all4 ,x w also awake to ! fact1 :i* %\ld h be5 evid5t ere ?is1 t ! no/rum bus9ess w\ld cease if physicians w\ld refuse to accept into _! (fices1 ev5 z a gift1 ! no/rum-promot+ m$ical j\rnals t live (f ?is trade4 ,fraudul5t 8pat5t m$ic9es0 w cont9ue to ?rive j s long z newspap]s w publi% 8pat5t m$ic9e0 adv]tisem5ts2 fraudul5t 8e?ical propriet>ies0 w cont9ue to exi/ j s long z m$ical j\rnals w adv]tise su* propriet>ies4 ,z ! bett] class ( newspap]s are reject+ 8pat5t m$ic9e0 adv]tis+ on _! own volition1 s are ! bett] class ( m$ical j\rnals reject+ adv]tisem5ts ( fraudul5t propriet>ies4 ,"s newspap]s w cont9ue to c>ry no/rum adv]tis+ until _! subscrib]s raise a prote/ t w cause ! bus9ess dep>tm5t to take notice2 s1 too1 "s m$ical j\rnals w cont9ue to %>e ! pr(its ) ! no/rum exploit]s until an outrag$ m$ical pr(ession repudiates su* publications4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,feb4 #f1 #aiae47 #hi ,! ,j\rnal ,a4 ,m4 ,a41 ,april #bj1 #aijg1 repr9t$ 9 8,propag&a = ,re=m10 #h? ,edition4 ,,?ialion ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! foll[+ report 0 submitt$ to ! ,c\ncil by a subcommittee :i* exam9$ ,?ialion 7,vass ,*emical ,company73 ,to ! ,c\ncil on ,ph>macy & ,*emi/ry3--,we beg leave to report on ,?ialion z foll[s3 ,?ialion is sold by ! ,vass ,*emical ,co41 ,danbury1 ,conn4 ,9 ! lit]ature suppli$ to physicians & 9 ! adv]tisem5ts 9 m$ical j\rnals1 ,?ialion is /at$ to be 8a laxative salt ( li?ia0 ) ! *emical =mula 8#c,li#b,o4,na,o4,,s#c4g;,,ho40 8,sodio-trili?ic anhydrosulphate0 is giv5 z a synonym4 ,an elaborate graphic or /ructural =mula is also giv54 ,accord+ to analyses1 ?is prep>ation is a mixture consi/+ *iefly ( sodium sulphate & sodium citrate ) v small am\nts ( li?ium1 ! av]age ( sev]al e/imations indicat+ ! foll[+ composition3 ,sodium citrate #eh4f ,sodium sulphate1 anhydr\s #bf4f ,sodium *lorid #c4c ,li?ium citrate1 anhydr\s #a4h ,wat] #i4g ,?us1 ! adv]tis+ lit]ature is a delib]ate misrepres5tation ( ! facts4 ,x is1 !re=e1 recomm5d$ t ! prep>ation be refus$ recognition1 & t ?is report be publi%$4 ,! recomm5dations ( ! subcommittee 7 adopt$ by ! ,c\ncil & 9 accordance !re) ! above report is publi%$4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,9 publi%+ ! above report1 ! ,c\ncil is pres5t+ to ! m$ical pr(ession ano!r object lesson1 & "o t illu/rates h[ easily our pr(ession is be+ humbugg$4 ,!re are sev]al ?+s t we may le>n f ! report on ?is no/rum1 b at ?is "t we w take up only "o phase ( ! lesson4 ,_m ( ! sci5tific *emical comp\nds & d]ivatives giv5 u by ! ,g]man *emi/s h be5 di/9ct advancem5ts & h prov$ to be valuable additions to our !rapeutic ag5ts2 fur!r1 !y 7 receiv$ ) s mu* favor by physicians t !y h be5 pr(itable = ^? :o made !m4 ,x is n /range1 !re=e1 t imitators %\ld appe>4 ,"o ( ! fir/ 0 our old fri5d1 ,antikamnia 7:i* 0 introduc$ z a 8new syn!tical0 comp\nd74 ,?is 0 foll[$ by ,ammonol1 ,ph5alg91 ,salacet91 & a ho/ ( o!rs hav+ acetanilid z _! pr9cipal +r$i5t4 ,illu/ration3 ,?is picturesque 8graphic =mula0 = ,?ialion appe>s ) _m ( ! adv]tisem5ts4 ,to mo/ ( u x looks =midable1 wond]fully & deeply sci5tific & non-und]/&able2 to a *emi/ x looks absurd4 ,b !re are hundr$s ( o!r s-call$ 8new *emical0 comp\nds among ! 8e?ical0 propriet>ies on ! m>ket aside f ! acetanilid mixtures4 ,^! wond]ful comp\nds1 by ! my/]i\s union ( _! +r$i5ts1 possess !rapeutic prop]ties diff]5t f1 or m p[]ful = good ?an ! drugs f :i* !y are made4 ,at lea/1 ?is is :at we are told1 & ?is is :at _m believe or !y w\ld n sell s well4 ,!re is ano!r factor wor? notic+ connect$ ) ?is subject3 ,:5 to ! claim t ! mixture is a 8*emical comp\nd0 is add$ a complex *emical =mula1 x prev5ts ! imp]t95t "q1 8,:at is x80 ,= isn't ! 8=mula0 !re1 & is n ! in=mation giv5 )\t ! ask+8 ,mo/ ( u h be5 s ov]come by ! display ( ! *emical k ( ! no/rum mak] t we h be5 afraid to expose our ignorance by ask+ = in=mation or explanation4 ,& ?us ! promot] avoids p]plex+ que/ions1 :i*1 if answ]$ tru?fully1 w\ld spell bankruptcy4 ,to a *emi/ ! =mula ( ,?ialion furni%$ by ! ,vass ,*emical ,company signifies no?+4 ,to a physician :o possesses b little k ( *emi/ry1 x w seem impressive1 & he may absorb ! idea t x /&s = a prep>ation t is ! result ( exhau/ive sci5tific rese>*4 ,to ! *emi/1 ?is =mula w appe> z a jumble ( symbols & numb]s t mean no?+4 ,x is n wor? :ile to call att5tion to ! simplicity ( ?is simple mixture ( ord9>y salts1 = x is too self-evid5t4 ,z to ! rem>kable !rapeutic qualities ( ,?ialion1 ! read] is ref]r$ to t ably edit$ 8sci5tific0 p]iodical1 ! ,uric ,acid ,mon?ly1 & to ! mass ( 8lit]ature0 relat+ to ?is wond]ful rem$y4 ,:ile !re is a ridicul\s side to ?is bus9ess1 !re is also a s]i\s "o4 ,^? :o h be5 mak+ money out ( u und\bt$ly laugh 9 _! sleeves at our gullibility1 b to u z memb]s ( a presumably le>n$ & intellig5t pr(ession1 x is n a laugh+ matt]4 ,! :ole no/rum bus9ess is a %ame & a disgrace4--7,modifi$ f ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #c1 #aijf47 ,,ungu5tum ,,sel5io ,,vanadic 7,v4 ,,roem]7 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,ungu5tum ,sel5io ,vanadic 7v4 ,roem]7 is an o9tm5t manufactur$ by ,a4 von ,roem]1 ,brooklyn1 ,n4 ,y41 & put on ! m>ket by ,s*]+ & ,glatz1 ,new ,york4 ,x is claim$ to conta9 #a p] c5t4 ( sel5ium oxycyanid & #a p] c5t4 ( vanadium *lorid 8s prep>$ & incorporat$ into a modifi$ lanol9 base z to insure complete absorption40 ,! prep>ation is recomm5d$ 9 ! lat] /ages ( inop]able c>c9oma1 s>coma1 epi!lioma & o!r malignant tumors1 z a sub/itute = morph9 & o!r n>cotics to control pa91 z a modify+ 7ante-op]ative7 treatm5t 9 ! middle /age ( malignant cases pres5t+ ! *>act]i/ics ( be+ inop]able1 & z a prophylactic treatm5t ( recurr5ces & meta/ases foll[+ excision ( malignant tumors4 ,x is also recomm5d$ = use 9 sl[-heal+ surgical w\nds1 abscesses1 tub]cul\s & mix$ septic & gangr5\s processes1 etc41 9 lupus1 acne1 eczema1 psoriasis1 scabies1 ery!mata1 ad5omata1 angiomata1 papillomata1 etc4 ,! use ( ! o9tm5t is fur!r recomm5d$ by sy/emic inunction 9 septicemia1 pneumonia1 erysipelas1 c]ebrosp9al m5+itis1 septic rheumatism1 septic neuritis1 etc4 ,! ,c\ncil vot$ t ! prep>ation be n accept$ = inclusion ) ,new & ,non(ficial ,rem$ies because no evid5ce has be5 submitt$ t ! vanadium & sel5ium are absorb$ or t !y produce any ( ! effects claim$4 ,:5 ! prec$+ report 0 s5t to ,s*]+ & ,glatz1 ! firm express$ surprise t evid5ce ( ! absorption ( sel5ium & vanadium %\ld be reque/$4 ,on ,june #h ! firm wrote t )9 a few days "o or m te/s w\ld be s5t by :i* ! pres5ce ( sel5ium & vanadium 9 ! ur9e c\ld be demon/rat$4 ,^! te/s 7 n receiv$4 ,s f> 7,novemb]1 #aiad7 no evid5ce ( ! value ( ! prep>ation ei!r 9 c>c9oma or 9 any ( ! v long li/ ( o!r diseases 9 :i* x is recomm5d$ has be5 submitt$1 &1 ! ph>macologic evid5ce t su* a prep>ation w\ld be ( value 9 su* conditions be+ practically nil1 ! ,c\ncil au?oriz$ publication ( ?is report4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #ba1 #aiad47 ,,unicorn ,,root1 ,,wild ,,yam ,,& ,,wild ,,indigo ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! ,c\ncil has vot$ t recognition be refus$ to ! foll[+3 ,unicorn ,root 7,aletris f>9osa71 ,wild ,yam 7,dioscorea villosa71 & ,wild ,indigo 7,baptisia t9ctoria7 & has au?oriz$ ! publication ( ! foll[+ /atem5ts4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,unicorn ,root--,aletris ,f>9osa ,unicorn ,root 7,aletris f>9osa7 conta9s a bitt] pr9ciple & />*4 ,rem>kable p[]s z a ut]9e tonic h be5 ascrib$ to x b h n be5 realiz$ by reliable obs]v]s1 ! drug be+ practically valueless 9 ^! conditions4 ,x ent]s into ! composition ( a numb] ( no/rums4 ,z a bitt] x is sup]flu\s & x %\ld n be includ$ among non-(ficial drugs4 ,wild ,yam--,dioscorea ,villosa ,wild ,yam 7,dioscorea villosa7 has be5 little us$ 9 m$ic9e4 ,x conta9s a sapon9 & an acrid res91 & is said to possess expectorant1 diaphoretic &--9 l>ge doses--emetic prop]ties4 ,x has be5 recomm5d$ z a rem$y 9 bili>y colic & 9 muscul> rheumatism4 ,its value 9 su* conditions has n be5 v]ifi$ to an ext5t entitl+ x to consid]ation z a useful rem$y4 ,wild ,indigo--,baptisia ,t9ctoria ,wild ,indigo 7,baptisia t9ctoria7 has be5 9 use--*iefly by ! eclectics--= ab\t ?ree-qu>t]s ( a c5tury1 b !re is no satisfactory evid5ce t x has any !rapeutic value4 ,! foll[+ text-books on ph>macology d n ev5 m5tion wild indigo3 ,cu%ny1 ,brunton1 ,dixon1 ,b9z1 ,sollmann4 ,x is n (ficial 9 ! ,unit$ ,/ates or o!r lead+ ph>macopeias4 ,a prep>ation ( wild indigo is adv]tis$ ) extravagant claims = its !rapeutic action1 b ^! claims are n support$ by any sub/antial evid5ce4 ,o!r virtues ascrib$ to wild indigo are its prop]ties z a c>diac & hepatic /imulant & its value 9 sepsis1 p>ticul>ly 9 typhoid fev]4 ,x actually has emetic & ca?>tic prop]ties1 b ev5 ^! are inf]ior to ^? possess$ by _m o!r drugs4 ,x is v evid5t t a drug possess+ ! extraord9>y m]its t h be5 claim$ = wild indigo w\ld n h rema9$ unnotic$ by ! lead+ au?orities on ph>macology & !rapeutics1 especially aft] its prolong$ use 9 m$ic9e4 ,ow+1 !re=e1 to ! lack ( sub/antial evid5ce ( its usefulness1 baptisia is n consid]$ z ( suffici5t importance to w>rant its inclusion 9 ! li/ ( non-(ficial drugs4 ,x is probably entirely sup]flu\s4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #bb1 #aiaj47 ,,propriet>y ,,vanadium ,,prep>ations ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry on ,products ( ,vanadium ,*emical ,co43 ,vanadiol1 ,vanadioseptol1 ,phospho-,vanadiol1 ,vanad(orme1 etc4 ,vanadiol & prep>ations !re(1 ! products ( ! ,vanadium ,*emical ,company1 7 submitt$ to ! ,c\ncil4 ,aft] ?or\gh inve/igation x 0 conclud$ t ! company has n1 & nev] has _h1 any reliable evid5ce = ! !rapeutic claims x has pres5t$ to ! m$ical pr(ession reg>d+ ^! products4 ,accord+ly ! ,c\ncil vot$ t ! sev]al products "u consid]ation be n accept$ = inclusion ) ,new & ,non(ficial ,rem$ies4 ,! f9d+s ( ! ,c\ncil hav+ be5 submitt$ to ! ,vanadium ,*emical ,company & its reply consid]$1 ! ,c\ncil au?oriz$ publication ( ! report :i* appe>s bel[4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,! ,vanadium ,*emical ,company1 ,pittsburgh1 ,pa41 submitt$ to ! ,c\ncil on ,ph>macy & ,*emi/ry = inclusion 9 ,new & ,non(ficial ,rem$ies ! foll[+ products3 ,vanadiol1 ,vanadioseptol1 ,phospho-,vanadiol1 ,vanadium ,solution = ,intrav5\s & ,hypod]mic ,use & ,vanad(orme4 ,at ! same "t1 ! company submitt$ /atem5ts & 8lit]ature0 reg>d+ ! composition & !rapeutic value ( ^! products4 ,! committee to :i* ! matt] 0 ref]r$1 aft] c>efully consid]+ bo? ! matt] pres5t$ & c]ta9 modifications 9 ! adv]tis+ matt] to :i* ! company cons5t$1 report$ t ! evid5ce1 especially t relat+ to ! !rapeutic value ( ! prep>ations1 0 insuffici5t to w>rant ! acceptance ( ! articles4 ,s9ce ! validity ( !rapeutic claims c be det]m9$ to a c]ta9 ext5t by exp]im5tal inve/igation1 ! ,c\ncil decid$ to po/pone f9al action until suffici5t dep5dable evid5ce z to ! !rapeutic value _h be5 submitt$4 ,accord+ly1 a s]ies ( que/ions 0 s5t to ! ,vanadium ,*emical ,company = ! purpose ( le>n+ on :at ph>macologic evid5ce ! !rapeutic claims 7 bas$4 ,aft] wait+ sev]al mon?s1 ! in=mation reque/$ n be+ furni%$1 ! ,c\ncil took f9al action on ! products4 ,?is action 0 bas$ bo? on ! evid5ce orig9ally submitt$ & on ! adv]tis+ matt] be+ s5t out by ! company at ! "t4 ,briefly1 ,vanadiol is said to conta9 a comp\nd ( vanadium ) oxyg5 & *lor91 :i* gives up its oxyg5 to readily oxidizable sub/ances1 su* z ! blood4 ,9 addition to ?is comp\nd x conta9s an oxidiz+ ag5t 7sodium *lorate7 :i* is said to s]ve z a s\rce ( oxyg51 s t1 accord+ to ! !ory ( ! promot]s1 ,vanadiol acts 9 ! animal sy/em z an oxyg5-c>ri]4 ,! foll[+ is quot$ f an adv]tis+ circul>3 8,mo/ ?or\gh & conclusive physiological te/s 7 made on gu9ea-pigs & o!r animals1 :i* e/abli%$ und\bt$ evid5ce z to ! tru? ( ?is !ory4 8,,influ5ce 8,"u ! influ5ce ( ,vanadiol & ! o!r d]ivatives1 ! appetite is increas$1 !re is great] ability to peptonize +e/$ proteid mat]ial1 &1 ?r\gh ! improvem5t 9 ! assimilative p[]s & ! *eck+ ( abnormal f]m5tations1 leads to an increase 9 weight4 ,a great] excretion ( urea foll[s _! use4 ,phagocytic action is promot$ by an increase 9 ! leucocytes4 ,all phases ( ! elim9ation ( wa/e mat]ials are favor$ by ! positive increase 9 ! numb] ( r$ blood corpuscles & ! p]c5tage ( hemoglob91 hematog5esis be+ !reby r5d]$ m p]fect4 ,! b5efic5t effect ( nasc5t 7active7 oxyg51 ^u ! r$ corpuscles & ^u tissue cells ( l[ vitality are matt]s ( common k4 ,! results obta9$ f ! vanadium d]ivatives are n drug effects1 b are due to improv$ metabolism1 :i* 9 turn is due to ! removal ( microbian tox9s1 & ! g5]al /imulation ( cell activity4 8,9 a tub]cul> organism1 ! action ( ,vanadiol is two-fold4 ,fir/1 x acts z an antiseptic & antitox91 combat+ ! ,ko* bacilli & neutraliz+ _! poison4 ,second1 z a recon/itu5t ( ! economy1 to :i* x furni%es nasc5t oxyg51 =tify+ ! def5seless cells by ! v elem5t t is necess>y to make !m heal?y & resi/ant40 8,9 ,anemia & ,*lorosis1 ! blood cells lack oxyg51 & 9 ,neura/h5ia ! n]ve cells are defici5t4 ,vanadiol br+s bo? blood & n]ve cells f a condition ( weakness & decay into vital en]gy1 by furni%+ !m ) active oxyg5 9 a mann] t _h n be5 possible by any o!r m$ic9e40 8,vanadiol accel]ates ! "w ( dige/ion by produc+ ,h,cl 9 small doses2 x does n h9d] ! peptonization ( album9oids z d beta-naph?ol1 salicylic acid1 boric acid1 etc41 :5 us$ z a /oma*al antiseptic1 b on ! contr>y x favors1 by hydro*loric acid1 ! trans=mation ( album9oids into peptone )\t ! assi/ance ( peps94 ,?us1 ,vanadiol1 :5 giv5 to consumptives1 favors ! dige/ion ( l>ge am\nts ( proteid mat]ials & causes oxidation ( tox9s ( ! /oma*4 ,! /oma*ic action is reflect$ 9 o!r p>ts ( ! organism by ! /imulation ( ! *ief functions2 ! pulse becomes /rong] & muscul> /r5g? increases2 &1 la/1 b ( greate/ importance1 is ! trem5d\s increase :i* w be not$ 9 ! hemoglob9 & ! r$ cell c\nt40 8,phospho-,vanadiol1 a comb9ation ( ,vanadiol ) an easily assimilable organic phosphorus1 is an active accel]ator ( g5]al nutrition ) a special action on ! n]v\s sy/em40 ,su* rem>kable /atem5ts z ^! are pa/ cr$5ce1 c]ta9ly1 unless !y are support$ by sci5tific evid5ce4 ,& evid5ce1 ei!r 9 support or 9 contradiction ( ! claims made1 c\ld be obta9$2 = _m ( ^! actions1 at lea/1 are capable ( pro( by animal exp]im5tation4 ,! ,vanadium ,*emical ,company 0 ask$ to furni% su* pro( b fail$ to d s4 ,! inf]5ce is pla96 ,! committee has conclud$ t ! company has n1 & nev] has _h1 any reliable evid5ce on :i* to base ! !rapeutic claims x has pres5t$ to ! m$ical pr(ession4 ,"h ano!r fact %\ld be not$4 ,x is ! connection %[n 9 ,! ,j\rnal1 ,june #bb1 #aiab1 ( ! g5]al manag] ( ! ,vanadium ,*emical ,company1 ,f4 ,m4 ,turn]1 ) a fraudul5t obesity cure conc]n1 ! ,dr4 ,turn] ,company ( ,syracuse1 ,n4 ,y4 ,x seems1 moreov]1 by all ! evid5ce available1 t ,f4 ,m4 ,turn] is n au?oriz$ to use ! title ,m4,d42 yet1 "u ?is title 8 "n appe>$ on c>ds repres5t+ ! ,vanadium ,*emical ,company & "u ?is title1 also1 he publi%$ an article 9 a m$ical j\rnal recomm5d+ to ! m$ical pr(ession ! use ( ,vanadiol4 ,lat] ?is article 0 di/ribut$ z an adv]tis+ circul> by ! ,vanadium ,*emical ,company4 ,turn]'s connection ) ! ,dr4 ,turn] ,company is kn[n & ackn[l$g$ by ! ,vanadium ,*emical ,company1 yet x /ill reta9s him z g5]al manag]6 ,:ile !re is n necess>ily any direct relation betwe5 ! p]sonnel ( a propriet>y manufactur+ company & ! value ( t company's product1 x is natural t ! m$ical pr(ession %\ld view ) di/ru/ any conc]n manag$ by "o :o has previ\sly be5 connect$ ) su* a fraud z ! ,turn] obesity cure4 ,! committee !re=e recomm5ds t ! prep>ations ( ! ,vanadium ,*emical ,company be refus$ recognition1 & t ?is report be au?oriz$ = publication4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #ah1 #aiac47 ,,v5>s5 ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,! report :i* appe>s bel[ 0 s5t to ! ,intrav5\s ,products ,company = consid]ation4 ,hav+ consid]$ ! firm's reply1 ! ,c\ncil has au?oriz$ publication ( its report along ) ! explanation s5t by ! ,intrav5\s ,products ,company 9 ref]5ce to ! v>iable composition report$ = ,v5>s51 namely1 t 8only ! fir/ few exp]im5tal ampules1 s5t to ! doctors = cl9ical te/s1 7 made )\t ! ,m]curic ,iodide40 ,w4 ,a4 ,puckn]1 ,secret>y4 ,?is product is prep>$ by ! ,intrav5\s ,products ,company1 ,d5v]4 ,! adv]tis+ circul>s conta9 inconsi/5t /atem5ts z to its composition4 ,accord+ to "o circul> ,v5>s5 is 8444 a comp>atively non-toxic organic ars5ic comp\nd1 #j4f ,gm4 repres5t+ #bdg ,mg4 7#c-c_/d gra9s7 ( metallic ars5ic 9 *emical comb9ation44440 ,accord+ to ano!r circul> ,v5>s5 is 8444 a comp>atively non-toxic organic ars5ic comp\nd1 #j4f ,gm41 repres5t+ #bdg ,mg4 7#c-c_/d gra9s7 ( metallic ars5ic & 4#gh ,mg4 7#c_/bej gra97 metallic m]cury 9 *emical comb9ation40 ,nei!r "o ( ^! /atem5ts gives any in=mation z to ! actual composition ( ! product4 ,inquiry address$ to ! manufactur]s elicit$ ! reply t3 8,v5>s5 conta9s 9 ea* #e c4c4 #j4f ,gm4 ,sodium ,dime?yl ,ars5ate1 4#jjaf grams ( ,m]curic ,iodide1 4#jjdh grams ( ,sodium ,iodide 9 solution 9 a suitable vehicle = intrav5\s adm9i/ration40 ,! foll[+ report ( ! exam9ation ( ,v5>s5 is submitt$ by ! ,association's ,*emical ,laboratory3 ,,laboratory ,,report ,?ree ampules ( ,v5>s5 7 exam9$4 ,! fir/ ampule 0 label$ 8,a comp>atively non-toxic organic ars5ic comp\nd1 repres5t+ #bdg ,mg4 7#c-c_/d grs47 ( metallic ars5ic 9 *emical comb9ation4 #e c4c4--#j4f ,gm40 ,practically ! same /atem5t appe>$ 9 an adv]tis+ circul> wrapp$ ar\nd ! ampule4 ,! second & ?ird ampules bore labels id5tical ) ! fir/4 ,! circul>s diff]$ f t accompany+ ! fir/ ampule 9 t ! pres5ce ( m]cury is also ann\nc$1 ?us3 8,v5>s5 is a comp>atively non-toxic organic ars5ic comp\nd1 #j4f ,gm41 repres5t+ #bdg ,mg4 7#c-c_/d gra9s7 ( metallic ars5ic & 4#gh ,mg4 7#c_/bej gra97 metallic m]cury 9 *emical comb9ation & is s prep>$ & enhanc$ z to pres5t ! +r$i5ts to ! blood 9 _! mo/ acceptable =m40 ,?us1 al?\gh ! pot5t elem5ts said to be conta9$ 9 ,v5>s5 are nam$1 its *emical "* 7! comb9ation 9 :i* ! elem5ts occur7 is n disclos$4 ,! ampules conta9$ a transp>5t1 odorless solution1 possess+ ! yell[ color ( salv>san solution 7an aque\s solution ( sodium cacodylate1 m]curic iodid & sodium iodid 9 ! am\nts said to be pres5t 9 ,v5>s5 is colorless74 ,qualitative te/s demon/rat$ ! pres5ce 9 ea* ( ! ?ree ampules ( sodium cacodylate 7sodium dime?yl ars5ate71 & ! abs5ce ( ars5ites1 ars5ates1 phosphates1 arsanilates 7atoxyl1 soam97 & ars5ph5olam9s 7salv>san1 neosalv>san74 ,titrat$ ) normal hydro*loric acid1 us+ me?yl orange z indicator 7z outl9$ 9 ,new & ,non(ficial ,rem$ies1 #aiae1 p4 #dj71 ! ?ree ampules 7 f\nd to conta9 ! equival5t ( respectively1 #j4bai1 #j4bec & #j4baf ,gm41 or an av]age ( #j4bdd ,gm4 ars5ic4 7,accord+ to /atem5ts ( ! firm ea* #e c4c4 ( ,v5>s5 conta9s #j4f ,gm4 sodium dime?yl ars5ate sodium cacodylate1 equival5t to #j4bdg ,gm4 ars5ic or #da4ff p] c5t4 ,sodium dime?yl ars5ate1 z describ$ 9 ,new & ,non(ficial ,rem$ies1 conta9s #c molecules ( wat] & #ce p] c5t4 ars5ic4 ,?is indicates t ! sodium dime?yl ars5ate us$ 9 ,v5>s5 conta9s less wat] ( cry/allization ?an ! ,n4 ,n4 ,r4 product74 ,nei!r m]cury nor iodid c\ld be f\nd 9 ! fir/ ampule4 7,! company has s9ce expla9$ t m]cury 0 abs5t only f ! fir/ exp]im5tal samples47 ,! second & ?ird ampules conta9$ iodid & m]cury 9 small am\nt4 ,! exact quantity 0 n det]m9$ because1 on ! basis ( ! m]cury cont5t decl>$1 a s+le accurate m]cury e/imation w\ld h requir$ ! pur*ase ( some?+ l #be to #ajj ampules4 ,z ea* ampule sells = two doll>s1 ! co/ ( ! mat]ial 0 consid]$ prohibitive4 ,f ! =ego+ we conclude t ! fir/ ampule exam9$ consi/$ ess5tially ( a solution conta9+ #j4fbe ,gm4 ( sodium cacodylate1 ,n4 ,n4 ,r41 :ile ! second & ?ird ampules conta9$ #j4gbb ,gm4 & #j4fag ,gm4 sodium cacodylate1 respectively1 & 9 addition1 a m]cury comp\nd1 probably m]curic iodid1 dissolv$ by sodium iodid4 ,9 o!r t]ms1 ,v5>s5 z n[ m>ket$ is a simple solution conta9+ approximately #i gra9s ( sodium cacodylate1 #a_/dj gra9 ( m]cury 8b9iodide0 & #c_/d gra9 ( sodium iodid to ea* full dose4 ,9 ! pa/ ! prep>ation has be5 9 conflict--especially s]i\s because ( ! pot5t "* ( ! drug--) ,rule #a 7secrecy ( composition74 ,! manufactur]s h remov$ ?is conflict by furni%+ a /atem5t ( composition2 & x is to be expect$ t !y w likewise take /eps to remove ! manife/ly errone\s impression n[ likely to be ga!r$ f ! circul>s1 namely1 t ! prep>ation is r analog\s to salv>san4 ,^! conflicts1 h[ev]1 call = comm5t1 s9ce physicians h d\btless us$ ! mat]ial "u misappreh5sions4 ,z to !rapeutic claims1 ! prep>ation is said to be effective & safe 9 syphilis2 8l[] toxicity & great] spiro*aetacidal p[] ?an o!r kn[n ars5ic comp\nds0 are among ! claims4 ,no real evid5ce = ei!r ( ^! claims is pres5t$4 ,sodium cacodylate has be5 tri$ z an antisyphilitic1 b ) indiff]5t success2 c]ta9ly ! results h n be5 comp>able to ^? ( salv>san4 ,! m]cury c\ld conceivably enhance its effect1 b ! dosage appe>s too small & ! c\rse too %ort = ?is influ5ce to be pron\nc$4 ,moreov]1 a c>eful physician w\ld n give ars5ic & m]cury 9 fix$ proportions4 ,! claim ( comp>ative non-toxicity is probable en\gh f :at is kn[n ab\t ! cacodylate4 ,no physician %\ld feel 8safe10 h[ev]1 :5 inject+ intrav5\sly #j4f gm4 ( sodium cacodylate e f\r to six days4 ,aside f ! grave dang]s ( intrav5\s injection 9 g5]al1 ! possibility ( idiosyncrasies to ars5icals %\ld always be borne 9 m9d4 ,f9ally1 ,v5>s5 is claim$ to be 8indicat$0 9 pellagra1 tub]culosis1 anemia1 etc4 ,no evid5ce is pres5t$ on :i* to base an op9ion z to its effici5cy 9 pellagra4 ,^? :o h /udi$ t disease w\ld n be likely to resort to ?is treatm5t4 ,9 tub]culosis & anemia1 !re is no suffici5t advantage 9 giv+ ! cacodylate intrav5\sly4 ,to summ>ize1 ,v5>s5 treatm5t consi/s ess5tially 9 ! intrav5\s injection ( l>ge doses ( sodium cacodylate4 ,! o!r +r$i5ts1 z well z ! "n1 m]ely con/itute s mu* my/ification4 ,:ile ! cacodylate probably has "s effect on ! conditions = :i* x is advis$1 !re is no evid5ce t its value ev5 approa*es t ( salv>san 9 syphilis1 or t ! intrav5\s use is pref]able to ! ord9>y me?ods4 ,! dang]s are manife/1 al?\gh !y may n be s great z ) salv>san4 ,no ju/ification has be5 e/abli%$ = its use 9 tub]culosis & pellagra4 ,physicians :o wi% to try intrav5\s cacodylate adm9i/ration %\ld h a full realization ( ! dang]s ( su* treatm5t1 & 9 ord] to avoid fur!r risks1 w d well to refra9 f comb9+ o!r drugs ) ! cacodylate 9 fix$ proportions4 ,x is recomm5d$ t ,v5>s5 be held 9 conflict ) ,rule #f 7unw>rant$ !rapeutic claims71 ,rule #g 7poison\s +r$i5ts n /at$ on label71 ,rule #h 7"n does n express ! *emical composition7 & ,rule #aj 7unsci5tific comb9ation7 & t ?is report be publi%$4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,may #bb1 #aiae47 ,,v5od9e ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,v5od9e 7,! ,intrav5\s ,products ,co41 ,d5v]71 accord+ to in=mation s5t to ! ,c\ncil1 is 8an ,intrav5\s ,iod9e ,comp\nd0 put up 9 ampules ea* ( :i* conta9s 8#bh gra9s ( ,sodium ,iodide1 #a_/h gra9 ea* ( ,bee*wood ,creosote & ,guaiacol 9 a suitable vehicle1 & excipi5ts to enhance its compatibility ) ! circulat+ blood40 ,! 8,!rapeutic ,indications0 include 8infecti\s diseases1 su* z syphilis1 tub]culosis1 bron*itis1 bact]aemias associat$ ) *ronic & acute nephritis 7,bright's disease71 & o!r infections40 ,! ,c\ncil held z unw>rant$ & grossly exagg]at$ ! foll[+ !rapeutic claims3 7#a7 t ! full !rapeutic value ( iod9 m$ication _c be readily obta9$ except by intrav5\s injection2 7#b7 t ,v5od9e is 8( exceptional value 9 tub]culosis02 7#c7 t 9 pneumonia ,v5od9e 8comb9es ! anae/hetic prop]ties ( creosote & guaiacol ) ! g]micidal value ( iod9e02 7#d7 t 8,v5od9e 7or its iod9e compon5t7 has long enjoy$ an exceptional reputation0 z ( great value 9 _m infecti\s diseases includ+ bact]emias4 ,! facts on ^! po9ts are ! foll[+3 #a4 ,s9ce iodids are easily absorb$ f ! muc\s membrane ( ! ga/ro-inte/9al tract & are usually well tol]at$ by ! /oma*1 !re is no reason = resort+ to intrav5\s injection 9 _! adm9i/ration4 #b4 ,! indiscrim9ate adm9i/ration ( iodids = pulmon>y tub]culosis is /rongly to be condemn$4 ,! cases 9 :i* !y c be giv5 to tub]cul\s pati5ts )\t do+ h>m mu/ be v c>efully select$4 #c4 ,!re is no evid5ce ei!r t creosote is excret$ by ! lungs 9 suffici5t quantity to ex]t an ane/hetic influ5ce or t iod9 is pres5t 9 ! circulation ( ! lungs or 9 ! bron*ial secretions 9 a =m :i* is capable ( ex]t+ any g]micidal action :atev]4 #d4 ,x is g5]ally held t ! sy/emic adm9i/ration ( iod9 comp\nds 9 bact]emias is useless4 ,! ,c\ncil also held ! "n 8,v5od9e0 objectionable 9 t x fails to indicate ! *ief +r$i5t 7sodium iodid7 ( ?is simple ph>maceutical mixture4 ,! /atem5t 9 a circul> t 8,v5od9e is a /]ile solution repres5t+ #a4ed ,gm4 7#bd gra9s7 ( iod9e 9 *emical comb9ation toge!r ) creosote & guaiacol0 is likely to lead physicians to use ! prep>ation )\t consid]+ t its *ief con/itu5t is ! well-kn[n sub/ance sodium iodid1 p>ticul>ly s s9ce no ref]5ce to sodium iodid is made 9 ! circul>4 ,fur!rmore1 ! ,c\ncil held t ! comb9ation ( two su* simil> sub/ances z creosote & guaiacol 7! second a con/itu5t ( ! fir/7 z giv5 9 ! publi%$ =mula1 /amps ,v5od9e z unsci5tific2 x adds my/]y to ! prep>ation1 b does n increase its effici5cy1 & is !re=e aga9/ ! be/ int]e/s ( ! public4 ,! ,c\ncil vot$ t ,v5od9e be held ineligible = conflict ) ,rules #f1 #h & #aj4 ,?is report hav+ be5 submitt$ to ! manufactur]s1 9 accordance ) ! ,c\ncil's cu/om1 & ! reply af=d+ no reason = modify+ ! f9d+s1 its publication has n[ be5 au?oriz$4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,june #bf1 #aiae47 ,,v]acolate,,am ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,,am ,= report on a simil> comp\nd1 see ,taurocol1 p4 #aih4 8,v]acolate 7pla9710 8,v]acolate ) ,pancreat9 & ,peps90 & 8,v]acolate ) ,iron1 ,qu99e & ,/ry*n9e0 are propriet>y tablets m>ket$ by ! ,m>cy ,company1 ,bo/on4 8,v]acolate 7pla9740--,= ?is ! foll[+ non-quantitative =mula is giv53 8,a comp\nd conta9+ ! bile acids1 sodium glyco*olate1 sodium tauro*olate ) casc>a sagrada & ph5olph?ale940 ,! dose is ?ree tablets4 ,exam9ation 9 ! ,*emical ,laboratory ( ! ,am]ican ,m$ical ,association ( a specim5 ( 8,v]acolate 7pla970 indicat$ t !re 0 ab\t #bj mg4 7#a_/c gra97 ( ph5olph?ale9 to ea* tablet4 ,"o dose1 !re=e 7?ree tablets71 w\ld conta9 #a gra9 ( ph5olph?ale9--an av]age dose4 8,v]acolate ) ,peps9 & ,pancreat940--,! foll[+ 8=mula0 is giv5 = ?is mixture3 8,v]acolate #a-a_/d gra9 8,pure ,pancreat9 #a gra9 8,peps9 aseptic 7#a3c1jjj7 #a_/b gra9 8,oil pepp]m9t #a_/aj m940 7,note ! pres5ce ( two mutually incompatible dige/ive f]m5ts47 8,v]acolate ) ,iron1 ,qu99e & ,/ry*n9e40--,?is is /at$ to h ! foll[+ 8=mula03 8,v]acolate #a-a_/h gra9 8,r$uc$ ,iron #a gra9 8,qu99e ,sulphate #c_/h gra9 8,/ry*n9e ,sulphate #a_/ajj gra90 ,x w be notic$ t ^! mixtures increase 9 complexity until a comb9ation ( sev5 div]se +r$i5ts1 a v]itable %otgun mixture1 is evolv$4 ,9 none ( ! 8=mulas0 are ! proportions ( ! purgative drugs 9 ,v]acolate /at$4 ,9 ! second 8=mula10 ! dige/ants might z well be omitt$1 = ! pancreat9 is de/roy$ by peptic dige/ion & h5ce _c pass ! /oma* :ile ! peps9 is useless )\t hydro*loric acid1 &1 at any rate1 ( no value 9 ! inte/9e4 ,if "o is indicat$1 ! o!r is n4 ,yet ?is unsci5tific & complex comb9ation ( purgatives1 mutually incompatible dige/ive f]m5ts1 & oil ( pepp]m9t is call$3 8,a sci5tific ,bl5d+ ( ,dige/ive ,f]m5ts1 ,*olagogues & ,c>m9atives40 8444 = all =ms ( indige/ion & dyspepsia40 ,& ! ?ird1 an equally irrational & complex comb9ation1 is t]m$ 8,! ,ideal ,*olagogic ,tonic06 ,extravagant & ,mislead+ ,claims4--,true to type1 ! claims are magnifi$ 9 accordance ) ! numb] ( +r$i5ts4 ,= in/ance1 ( 8,v]acolate 7pla9710 we are told3 8,v]acolate is a true *olagogue & bili>y dis9fectant z x directly /imulates ! liv] cells produc+ an increas$ fl[ ( limpid bile4 ,al?\gh n a purgative1 x moves ! b[els & is def9ite & dep5dable 9 its action40 8,! action ( ,v]acolate is to br+ ab\t a pr(use fl[ ( heal?y bile :i* prev5ts bile /asis4 ,z ! fl[ ( bile is /imulat$ s antiseptic action ensues1 calculi s(t5$ & ! concretion & muc\s elim9at$4 ,mucosal swell+ is dim9i%$ & ! infection :i* is usually pres5t is antagoniz$4 ,relief is 9 pla9 evid5ce4 ,z a result ( ! treatm5t ! sk91 eyes & ur9e become normal 9 appe>ance 9 a %ort "t1 ! appetite & dige/ion improve & sor5ess 9 ! region ( ! gall-bladd] is entirely reliev$40 ,simil>ly1 x is said ( 8,v]acolate ) ,pancreat9 & ,peps90 t3 8,x causes a natural fl[ ( bile :i* *ecks f]m5tation1 prev5ts ! absorption ( tox9es & causes ! food elem5ts to be emulsifi$ & ?us r5d]$ easy ( assimilation4 ,all ?is conduces to a natural movem5t ( ! b[els4 ,dige/ion is at once improv$ & ! epiga/ric pa91 n]v\s symptoms & heada*e disappe>40 8,v]acolate ) ,iron1 ,qu99e & ,/ry*n9e0 is said to be indicat$ 93 8,hepatic ,torpor accompani$ by ,anemia1 ,*lorosis1 ,debility1 ,neura/h5ia & ,neuroses40 ,& ! physician is ask$ to believe t x w3 8444 give gratify+ results 9 all n]v\s1 anemic1 & #8run d[n' conditions 9 :i* ! liv] function is usually subnormal40 ,! objections to 8,v]acolate 7pla970 are t x is semi-secret 9 composition1 unsci5tific 9 comb9ation & exploit$ "u unw>rant$ claims4 ,! same criticisms hold ) ref]5ce to 8,v]acolate ) ,pancreat9 & ,peps90 & 8,v]acolate ) ,iron1 ,qu99e & ,/ry*n9e40 ,^! products are discr$itable to ! m$ical & ph>maceutical pr(ession alike & _! use is aga9/ ! public good4 ,! ,c\ncil !re=e refus$ recognition to ,v]acolate & its prep>ations4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,april #bd1 #aiae47 ,,hayd5',s ,,viburnum ,,comp\nd,,an ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,,an ,see also report on ,dioviburnia1 p4 #ada1 & article on ,viburnum ,comp\nd & ,o!r ,no/rums1 p4 #dji4 ,! foll[+ report on ,hayd5's ,viburnum ,comp\nd 0 prep>$ by a memb] ( ! ,c\ncil's ,committee on ,!rapeutics4 ,! ,c\ncil held ! prep>ation 9 conflict ) its rules & au?oriz$ publication ( ! ref]ee's report4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,hayd5's ,viburnum ,comp\nd1 accord+ to ! adv]tis+ circul>s1 0 fir/ comp\nd$ 9 #ahfj by ,w4 ,r4 ,hayd54 ,! m$ical pr(ession is told t ,w4 ,r4 ,hayd5 8444 f\nd by 8 exp]im5ts t a comb9ation ( ! active pr9ciples ( ,viburnum ,opulus1 ,dioscorea ,villosa1 comb9$ ) aromatics1 prov$ a valuable rem$y = ,spasmodic ,dysm5orrhea40 ,z 9 #ahfj ,w4 ,r4 ,hayd5 0 n a physician 7he receiv$ a diploma f ! ,eclectic ,m$ical ,college1 ,new ,york1 9 #ahfg71 &1 s f> z we c le>n1 he 0 n a ph>maci/ or *emi/1 "o wond]s :at k9d ( 8exp]im5ts0 he made4 ,hayd5's ,viburnum ,comp\nd is put on ! m>ket by ! ,new ,york ,ph>maceutical ,company ( ,b$=d ,spr+s1 ,mass4 ,! "n ( ?is conc]n may s\nd impos+1 until x is realiz$ t x is m]ely a trade "n adopt$ by ,hayd5 9 exploit+ 8 no/rum4 ,! adv]tis+ matt] =m]ly claim$ t ,scutell>ia 7skull-cap7 0 "o ( ! +r$i5ts ( ,hayd5's ,viburnum ,comp\nd4 ,z ?is is no long] m5tion$1 x is fair to assume t ev5 ! manufactur] does n consid] ! composition to be ( vital importance4 ,/ress is laid on ! sup]ior efficacy ( viburnum opulus 9 ! conditions = :i* ! prep>ation is recomm5d$2 x is emphasiz$ t x is viburnum opulus1 & n viburnum prunifolium1 t is ! important +r$i5t ( ,hayd5's ,viburnum ,comp\nd4 ,! label1 9 accordance ) ! requirem5ts ( ! ,food & ,drugs ,act1 decl>es t ! prep>ation conta9s #ej p] c5t4 alcohol4 ,! claim is made3 8,x is free f all n>cotics & leaves no unpleasant aft]-effects40 ,! m$ical pr(ession is told t ,hayd5's ,viburnum ,comp\nd is a rem$y 93 8,hy/]ia1 ,bili\s ,colic1 ,cramps ( ,*ol]a ,morbus1 ,muscul> ,cramps1444 ,n]v\s ,diseases ( ,pregnancy1 ,?reat5$ ,abortion1 ,po/-,p>tum ,pa9s1 ,pu]p]al ,convulsions1 ,rigid ,os1 ,dysm5orrhea1 ,m5orrhagia40 ,,discussion ,,( ,,alleg$ ,,+r$i5ts ,viburnum ,opulus 7,cramp ,b>k74--,botani/s & ph>maceutical *emi/s decl>e t ?is drug has n be5 on ! ,am]ican m>ket = _m ye>s1 if ev]1 & t ! drug us$ & ev5 describ$ z viburnum opulus is really ! b>k ( ano!r plant4 ,viburnum opulus & its prep>ations are !re=e to be dropp$ f ! next ,unit$ ,/ates ,ph>macopeia4 ,! pr9cipal con/itu5ts ( viburnum opulus are /at$ to be a glucosid1 viburn91 a bitt] res91 & a little tann91 ) small am\nts ( e>?y c>bonates & phosphates & organic acids 7,culbre?1 ,ed4 #d1 #aijf1 p4 #eia74 ,! glucosid & res9 be+ bitt]1 ! drug might h a slight /oma*ic action 7if1 inde$1 any su* effect is actually produc$ by 8bitt]s072 ! small am\nt ( tann9 might make x slightly a/r+5t2 its fruit acids 7citric & malic7 might make x slightly diuretic4 ,ev5 if viburnum opulus 7 pres5t 9 ,hayd5's ,viburnum ,comp\nd !re is no cl9ical or laboratory pro( t x1 if giv5 alone--)\t alcohol or o!r drug--has any antispasmodic or n]v\s s$ative action4 ,dioscorea ,villosa 7,wild ,yam74--,?is drug conta9s a sapon9 & an acrid1 irritant res94 ,x has nev] be5 prov$ cl9ically or exp]im5tally t ?is drug has any action :atev] except t its irritant res9 might1 if tak5 9 suffici5t quantity1 cause irritation ( ! /oma* & vomit+4 ,aromatics4--,! irritation produc$ by conc5trat$ aromatics causes increas$ p]i/alsis & consequ5tly may1 if !re is no ob/ruction1 relieve inte/9al /asis & inte/9al colics4 ,!re=e1 a prep>ation conta9+ l>ge am\nts ( aromatics1 especially if giv5 9 hot wat]1 w\ld h practically ! same effects 9 ! 8cramps ( a *ol]a morbus0 or o!r =ms ( acute di>rhea z a home-brew$ cup ( spic$ tea--& no m4 ,alcohol4--,?is drug is a muscle relaxant1 & suffici5t doses might1 by reliev+ spasm1 relax a muscul>ly contract$ os ut]i & relieve po/-p>tum pa9s4 ,alcohol dilates ! blood-vessels bo? 9 ! abdom5 & on ! surface ( ! body4 ,x may ?us ei!r relieve ut]9e ble$+ by l[]+ ! blood-pressure & caus+ m blood to g to o!r p>ts1 or increase ut]9e ble$+ by reliev+ art]ial & muscle spasm4 ,alcohol is also a habit-=m+ n>cotic 7,hayd5's ,viburnum ,comp\nd is adv]tis$ z 8free f all n>cotics067 & :5 habitually us$ by ei!r males or females t5ds to impair ! capacity to produce normal (fspr+4 ,ev5 if ! manufactur]'s 8=mula0 be accept$1 ,hayd5's ,viburnum ,comp\nd conta9s no !rapeutically active +r$i5t except alcohol & aromatics4 ,! recomm5d$ dose ( ?is prep>ation is 8444 two teaspoonfuls 9 six ( boil+ hot wat] or milk & "o teaspoonful ( sug>1 e fifte5 or tw5ty m9utes until relief is obta9$40 8,frequ5tly aft] tak+ ! ,viburnum ,comp\nd ! pati5t w sleep s\ndly = sev]al h\rs f ! sudd5 cessation ( pa92 9 su* cases %e %\ld nev] be awak5$ ?r\gh any fe> ( ov]sleep+1 z ,hayd5's ,viburnum ,comp\nd does n conta9 any n>cotic :atev]1 nor does x leave any disagreeable aft]-effects1 & x may be giv5 to a *ild :5 necess>y )\t any special caution40 ,read ! =ego+ & !n rememb] t x means t "o teaspoonful ( alcohol 7! equival5t ( two teaspoonfuls ( :isky7 is to be giv5 9 hot wat]1 e fifte5 or tw5ty m9utes until relief is obta9$ & ! pati5t is asleep4 ,:y n use pla9 language & say 8until %e is drunk08 ,! ?\ghtful physician w\ld consid] x decid$ly unwise to give alcohol to a "y girl1 to a prospective "m1 or to a "y "m1 except "u extraord9>y circum/ances4 ,he w\ld "k t ! m5/rual pa9s = :i* ?is prep>ation is recomm5d$ are likely to be recurr5t1 & t ! repeat$ tak+ ( alcohol = recurr5t pa9 is fraught ) dang]--! dang] ( initiat+ ! alcohol habit4 ,if1 h[ev]1 a physician does elect to give alcohol z a drug1 he mu/ let ! conditions t gov]n ea* individual case det]m9e :e!r x is n bett] to give x z :isky1 or to disguise x 9 a prescription ( 8 own4 ,above all ! physician %\ld be consci\s t he is giv+ ! drug1 alcohol2 & ?is is n ! case :5 he prescribes a ready-made no/rum4 ,if he writes a prescription conta9+ :isky or o!r alcoholic he w take measures to av]t ! dang]s insep>able f ! use ( ?is drug4 ,,conclusions #a4 ,ev5 if ! manufactur]'s =mula = ,hayd5's ,viburnum ,comp\nd be accept$1 x is app>5t t any !rapeutic activity ! prep>ation may h is due ess5tially to ! alcohol & aromatics4 #b4 ,alcohol is a n>cotic drug1 & a habit-=m+ drug4 ,physicians ord]+ ?is prep>ation may1 by s do+1 be initiat+ ! alcohol habit4 #c4 ,:atev] result is obta9$ by ! use ( ,hayd5's ,viburnum ,comp\nd 9 ! treatm5t ( ut]9e or pelvic di/urbances1 is due to ! alcohol x conta9s4 ,! fact t m5/rual pa9s are likely to recur might1 :5 ?is prep>ation is reli$ on1 become a factor 9 ! =mation ( ! alcohol habit4 #d4 ,:atev] result is obta9$ by ! adm9i/ration ( ,hayd5's ,viburnum ,comp\nd 9 ! treatm5t ( ga/ro-inte/9al di/urbances is due to ! alcohol & ! aromatics x conta9s4 #e4 ,:isky has ! same alcoholic cont5t 7#ej p] c5t47 z ,hayd5's ,viburnum ,comp\nd2 ! dang]s 9 ! use ( :isky are well kn[n & its value z a !rapeutic ag5t is be+ que/ion$ m & m e ye>4 ,hold+ ! exploitation ( ?is propriet>y a dang] to ! public & a detrim5t to sci5tific m$ic9e1 ! ref]ee recomm5ds publication ( ?is report z a prote/ aga9/ su* irrational !rapeutics4 ,! pr(ession %\ld recognize t mo/1 if n all1 ( ! prep>ations recomm5d$ = pa9ful m5/ruation & = all k9ds ( pelvic pa9 conta9 l>ge p]c5tages ( alcohol1 & t :atev] physiologic effect is produc$ is1 = all practical purposes1 due to ! alcohol4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #bc1 #aiae47 ,,v9 ,,m>iani ,report by ,c\ncil on ,ph>macy & ,*emi/ry--,) ,comm5ts ,!reon ,?is prep>ation 0 assign$ to a subcommittee ( ! ,c\ncil & ! foll[+ is an ab/ract ( ! report ( ! committee3 ,samples ( ,v9 ,m>iani & ( ! lit]ature di/ribut$ by ! manufactur]s 7 exam9$4 ,x appe>s t ! bev]age or m$ic9e kn[n z 8,v9 ,m>iani0 is a prep>ation ( r$ w9e1 app>5tly import$ f ,bordeaux1 & =tifi$1 9 ?is c\ntry1 by an alcoholic prep>ation ( coca leaves or o!r p>ts ( ! coca plant4 ,! committee consid]$ fir/1 ! "* ( ! r$ w9e z import$4 ,a sample receiv$ f ! port ( ,new ,york1 ,m>* #aj1 #aije1 f ,h5ry ,clausel ,co41 ,bordeaux1 & consign$ to ,m>iani ,co41 on analysis 0 f\nd to h ! foll[+ composition3 ,specific gravity #j4iiei ,alcohol by volume p] c5t4 #aj4ii ,extract p] c5t4 #b4bgi ,volatile acids p] c5t4 #j4jiad ,a% p] c5t4 #j4bhja ,r$uc+ sug> trace4 ,pol4 direct degrees --#j4h ,pol4 inv]t degrees --#j4g ,k4,s ,m4 p] lit] #j4jib ,a sample ( ,v9 ,m>iani1 z b\ght 9 ! op5 m>ket 9 an orig9al package1 has also be5 analyz$ & f\nd to h ! foll[+ composition3 ,specific gravity #a4jabe ,alcohol by volume p] c5t4 #af4ae ,extract p] c5t4 #h4fjb ,a% p] c5t4 #j4bgg ,glyc]9 p] c5t4 #j4ddd ,volatile acid p] c5t4 #j4jgdg ,t>t>ic acid p] c5t4 #j4bdjj ,alkaloids 7coca bases7 p] c5t4 #j4jbej ,cane sug> p] c5t4 #b4ce ,r$uc+ sug> p] c5t4 #c4ch ,! increas$ alcoholic /r5g? ( ,v9 ,m>iani ov] ! ,bordeaux w9e f :i* x is made1 z %[n by ?is analysis1 d\btless comes f ! alcohol extract conta9+ ! coca bases1 z already /at$4 ,approximately #f p] c5t4 ( sug> is also add$ to ! w9e4 ,judg+ f ! analysis1 !re=e1 ,v9 ,m>iani corresponds to a mixture ( an alcoholic prep>ation ( coca leaves & ord9>y ,bordeaux r$ w9e1 ) ! addition ( ab\t #f p] c5t4 ( sug>4 ,v9 ,m>iani conflicts ) ,rule #e1 :i* requires t 8,no article w be admitt$ or reta9$1 conc]n+ :i* ! manufactur] or 8 ag5ts make mislead+ /atem5ts z to geographical s\rce1 raw mat]ial f :i* made1 or me?od ( collection1 or prep>ation10 by /at+ 9 ! adv]tis+ lit]ature t3 8,! ,unit$ ,/ates gov]nm5t1 "u ! ,pure ,food ,law ( ,m>* #c1 #aijc1 fur!r emphasizes all previ\s analyses ( ,v9 ,m>iani by admitt+ ,m>iani's w9e z absolutely pure & unadult]at$40 ,:atev] may h be5 ! int5t ( ! above /atem5t1 its effect is to deceive4 ,! conjunction ( ! t]ms 8,v9 ,m>iani0 & 8,m>iani's w9e0 c only be con/ru$ z mean+ ! same ?+4 ,inasmu* z x does n appe> t ,v9 ,m>iani is import$ into ?is c\ntry1 x w\ld n h be5 possible = ! ,unit$ ,/ates gov]nm5t to inspect x1 & z to ! w9e obta9$ f ,h5ry ,clausel ,co41 f ,bordeaux1 x is n 9 any s5se ,m>iani's w9e except t ( own]%ip4 ,x is ! op9ion ( ! committee t ?is phrase c only result 9 deception & ! con/ruction ( ! language /rongly favors ! supposition t x is int5tionally meant to deceive4 ,?is false claim is practically repeat$ 9 ! o!r pamphlets publi%$ by ! ,v9 ,m>iani ,company1 al?\gh n always 9 ! same words4 ,?is prep>ation also conflicts ) ,rule #f1 :i* /ates t 8,no article w be admitt$ or reta9$ ( :i* ! manufactur] or 8 ag5ts make unw>rant$1 exagg]at$ or mislead+ /atem5ts z to !rapeutic value10 9 t ! firm's lett]-heads h pr9t$ on !m ! foll[+3 8,v9 ,m>iani purifies ! blood /ream1 /r5g!ns ! circulation1 /imulates muscul> fib] & n]ve tissue1 is a respiratory /imulant1 /r5g!ns ! he>t muscles1 & is an em]g5cy food 9 ! abs5ce ( all o!r nutrim5t4 ,successfully employ$ z an adjuvant 9 anemia1 debility1 diseases ( ! *e/1 n]v\s tr\bles1 muscul> or m5tal ov]/ra91 neura/h5ia1 & alli$ conditions1 & 9 c]ta9 cases ( protract$ convalesc5ce40 ,! committee believes t ,v9 ,m>iani is int5d$ z a bev]age r ?an z a m$ic9e4 ,! report concludes3 8,! committee recomm5ds1 !re=e1 t ,v9 ,m>iani be refus$ recognition & t ?is report be publi%$ 9 full or 9 "p40 ,9 accordance ) ?is recomm5dation ! above extract ( ! report is h]e) publi%$4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,,v9 ,,m>iani ,,made ,,9 ,,?is ,,c\ntry ,accord+ to ! above report1 ,v9 ,m>iani z import$ is simply an ord9>y *eap ,fr5* w9e1 ! prep>ation sold 9 ?is c\ntry z ,v9 ,m>iani be+ comp\nd$ 9 ?is c\ntry4 ,yet ! adv]tis+ lit]ature1 ! label on ! bottle1 etc41 /ate directly or indirectly t x is a ,fr5* prep>ation4 ,until rec5tly--presumably until ! v5dors realiz$ t ! tru? reg>d+ ?is po9t w\ld come out--! adv]tisem5ts 9 m$ical j\rnals conta9$ an analysis made by a *emi/ 9 ,p>is4 ,! %ape ( ! bottle1 ! "* ( ! pr9t$ matt] accompany+ ! bottle1 etc41 are evid5tly int5d$ to convey ! impression t x is import$4 ,s f>1 !n1 z ?is po9t is conc]n$1 ,v9 ,m>iani is sold "u gross misrepres5tations & is a fraud4 ,illu/ration3 ,adv]tisem5ts ( ,v9 ,m>iani be=e & aft] national ,food & ,drugs ,act w5t into effect4 ,,adv]tis$ ,,to ,,! ,,public ,v9 ,m>iani 0 at "o "t adv]tis$ to ! public 9 ?is c\ntry1 b1 s f> z we "k1 x is n at ! pres5t "t2 at lea/1 n directly4 ,yet x is mo/ effectively adv]tis$ to ! public indirectly1 & ?is ) little exp5se to ! promot]s1 ! co/ ( ! circul> ar\nd ! bottle be+ ! only exp5se--doctors :o prescribe x d ! re/4 ,if ^? :o are 9 ! habit ( prescrib+ ,v9 ,m>iani w exam9e ! adv]tis+ t goes into ! h&s ( _! pati5ts !y w realize h[ true x is t our pr(ession is responsible = mu* ( ! 8pat5t-m$ic9e0 tak+4 ,few laym5 c\ld )/& ! temptation to buy ! /uff = any ailm5t t comes along :5 !y read 9 ! circul> t ?is 8m$ic9e10 :i* _! doctor evid5tly ?9ks is a good ?+1 is s highly recomm5d$1 = all ! ills t befall u mortals1 by ! ,pope ( ,rome1 ! ,cz> & ! ,cz>9a ( ,russia1 ! ,que5 ( ,engl&1 ! ,%ah ( ,p]sia1 ! ,k+ ( ,norway & ,sw$51 ! ,que5 ( ,portugal1 ! ,que5 ( ,saxony1 ! ,cr[n ,pr9ce ( ,cambodia1 ,f]d9& ( ,bulg>ia1 & by a :ole li/ ( ambassadors1 g5]als1 politicians1 musicians1 actresses1 etc4 ,! te/imonials ( ^! great m5 & wom5 are en\gh to conv9ce ! mo/ skeptical t ?is rem>kable m$ic9e w d ev]y?+ b raise ! dead--& "u favorable circum/ances accompli% ev5 ?is4 ,& /ill m--x w w9 battles6 ,witness ?is f ! gov]nor-g5]al ( ,madagasc>3 8,we 7 refre%$ by ,v9 ,m>iani1 & be=e morn+ c>ri$ ! /ronghold40 ,alex&] ,dumas & ,emile ,zola are cr$it$ ) call+ x 8! elixir ( life40 ,"o v /range ?+ ab\t ! te/imonials 9 ! circul> us$ 9 ?is c\ntry is t all are writt5 by =eign]s4 ,b ,am]icans 7,presid5t ,mc,kinley--?9k ( x--among o!rs7 are honor$ by hav+ _! te/imonials quot$ 9 ! circul>s us$ on ! o!r side ( ! ,atlantic4 ,:y8 ,is x possible t ! te/imonials are fakes8 ,,an ,,e?ical ,,cure-,,all ,"h are a few ( ! conditions t ! circul> says ,v9 ,m>iani is good =3 8,anemia1 w9t] c\gh1 debility1 vocal weakness1 la grippe1 cont9u$ fev]s1 bron*itis1 n]v\s tr\bles1 muscul> weakness1 diseases ( ! ag$1 mal>ia1 melan*olia1 ov]work1 neura/h5ia1 impot5ce1 malnutrition1 depression1 he>t tr\bles1 wa/+ diseases1 m5tal ov]/ra91 & 9 c]ta9 cases ( protract$ convalesc5ce40 ,! foll[+ quotations are tak5 f blott]s--circulat$ 9 ?is c\ntry--:i* are evid5tly int5d$ = ! laity1 z well z = physicians3 8,v9 ,m>iani creates & su/a9s vigor & en]gy4 ,gu>ds aga9/ wa/+ diseases4 ,:5 ev]y?+ else has fail$ try x to prove m]its40 8,lung1 ,?roat & ,/oma* ,tr\bles b5efit$ by ,v9 ,m>iani2 ?is ,ideal ,fr5* ,tonic /r5g!ns entire sy/em ( ,body1 ,bra9 & ,n]ves40 8,mo/ ,efficaci\s1 ,mo/ ,agreeable1 ,unequal$ by any?+ 9 ,=tify+1 ,/r5g!n+1 ,refre%+40 ,,:y ,,blame ,,! ,,layman ,,= ,,us+ ,,no/rums8 ,c we blame ! layman = us+ ,p]una1 ,w9e ( ,c>dui1 etc41 simply because !y are adv]tis$1 :5 !re are physicians :o1 = ! same reason1 prescribe concoctions t are j z quacki% & j z useless8 ,& c editors ( m$ical j\rnals consi/5tly f9d fault ) newspap]s = c>ry+ adv]tisem5ts ( fraudul5t 8pat5t m$ic9es0 :5 !y !mselves admit to _! pages adv]tisem5ts ( no/rums t are no less fraudul5t & ( no m value8 ,,memb] ,,( ,,propriet>y ,,association ,"o ^w m3 ,!re is an organization kn[n z ! ,propriet>y ,association ( ,am]ica1 b x is usually ref]r$ to 9 common p>lance z ! 8pat5t-m$ic9e0 m5's association4 ,x w be rememb]$ t la/ ye> we pr9t$ a li/ ( ! memb]s ( ?is body1 among :i* 0 ! ,v9 ,m>iani ,company4 ,x w be rememb]$ also t 9 ! li/ 7 ! names ( c]ta9 firms :o 7 supply+ m$ic9es to physicians1 b practically all ^! resign$ f memb]%ip & _! resignations 7 publi%$ by u4 ,we h n _h ! pleasure ( publi%+ ! resignation ( ! ,v9 ,m>iani ,company4 ,on ! contr>y1 we note t at ! la/ annual meet+ ( ! 8pat5t-m$ic9e0 m5's association ?is firm 0 /ill an active memb]1 ,mr4 ,a4 ,l4 ,j>os1 :o /&s = ! ,m>iani ,company 9 ?is c\ntry1 be+ "o ( ^? regi/]$ at ! meet+4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #bf1 #aijf47 ,,virol ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry ,virol1 sold 9 ! ,unit$ ,/ates by ! ,etna ,*emical ,company1 is put out by ,virol1 ,ltd41 ,london1 ,engl&4 ,x is said to be 8,a prep>ation ( bone m>r[1 r$ bone m>r[ ( m$ull>y /ructure ( ox rib & calf bones1 eggs1 malt extract1 & lemon syrup made f fre% fruit40 8,m>r[ fat is emulsifi$ ) extract ( malt1 lemon syrup & eggs1 x is fur!r enri*$ ) soluble phosphates ( lime1 iron & soda1 & glyc]9e solution ( r$ bone m>r[40 ,_m ( ! !rapeutic claims made = ,virol ! ,c\ncil consid]$ grossly exagg]at$2 among !m are ! foll[+3 8444 a complete food = *ildr540 8444 a complete nutri5t40 8,! value ( ! ,lime-,salts 7repres5t+ ! ,egg ,%ells7 conta9$ 9 ,virol is fully illu/rat$ 9 its influ5ce ^u ,rickets2 :il/ ,/ruma1 ,*ronic ,bron*itis1 ,anaemia & ,influ5za are all combat$ by its use 9 a degree1 :i*1 we v5ture to say1 has nev] be5 approa*$40 8,! fat1 z repres5t$ by ! ,m>r[-bone & ,egg ,yolk1 is s m9utely divid$ t x admits ( ev5 f> m rapid absorption by ! villi ( ! inte/9e ?an milk40 8,x is an ideal =m ( food1 readily dige/$ & assimilat$ 9 ! weake/ ( conditions40 8,virol has a m>k$ effect on ! metabolism ( ! body1 increas+ ! production ( opson9s & /imulat+ phagocytosis4 ,z an adjuvant to ! natural def5sive processes ( ! pati5t 9 all diseases ( bact]ial orig9 its value c sc>cely be ov]-e/imat$40 ,! objections ( ! ,c\ncil 7 transmitt$ to ,virol1 ,ltd4 ,! firm's reply 0 report$ to ! ,c\ncil by ! ref]ee ( ! ,committee on ,!rapeutics :o held t no adequate or satisfactory answ] _h be5 made to ! objections rais$ aga9/ ! adv]tis+ claims = ,virol4 ,! claims made = ,virol be+ unsub/antiat$ & unw>rant$1 ! ,c\ncil vot$ t ! prep>ation be refus$ recognition4 ,9 accordance ) ! practice ( ! ,c\ncil1 ! exploit]s ( ,virol 7 af=d$ an opportunity to comm5t on ! =ego+ /atem5t be=e its publication4 ,on _! object+ to ! f9d+s1 ! entire matt] 0 turn$ ov] to a second ref]ee4 ,?is ref]ee1 9 mak+ 8 report1 review$ ! claims made = ,virol & comm5t$ on ! lack ( evid5ce to sub/antiate ^! claims4 ,he /at$ t a *emical analysis ( ! prep>ation _h yield$ ! foll[+ result3 8,sug>1 z maltose #fj4j p] c5t4 8,fat #ac4b p] c5t4 8,prote9s #c4b p] c5t4 8,a% #a4f p] c5t4 8,wat] & volatile matt] #ba4f p] c5t4 8,!re is no appreciable dia/atic action4 ,a little glyc]ol is pres5t 9 ! volatile matt]4 ,! prep>ation is !re=e an extract ( malt ) fat & a small am\nt ( prote940 ,he !n cont9ues3 8,t ,virol has food value _c be d5i$1 b t x has suffici5t value to w>rant ! claims ( ! manufactur]s is n evid5t4 ,virol _c be consid]$ a complete food1 z ! adv]tis+ lit]ature reit]ates1 or an ideal food = infants4 ,! am\nt ( prote9 is f> too l[ 9 comp>ison ) ! c>bohydrates to w>rant ?is view4 ,! dosage recomm5d$ is n l>ge4 ,?irty gm4 a day w\ld furni% only ab\t #a gm4 ( prote9 & #d gm4 ( fat4 ,! #c teaspoonfuls a day recomm5d$ = *ildr5 w\ld furni% prote9 & fat ev5 bel[ ?is4 8,if employ$ alone x _c be a complete or suffici5t food1 & if employ$ along ) o!r articles ( diet--milk & bread1 = example--x is n easy to see :]e9 lies ! efficacy ( ! small weights ( fat & prote9 add$ 9 ! =m ( ,virol4 ,"h ! dem& made on our cr$ulity is too great1 z ! prote9 9 ! prep>ation is ! famili> prote9 ( eggs1 meat & malt1 & ! fat l>gely t f ! egg-yolk & m>r[1 accord+ to ! claims4 ,x is n kn[n t any specific virtues reside 9 ^! bodies1 or 9 ! egg-%ells1 also claim$ z pres5t4 8,9 ! op9ion ( ! pres5t ref]ee !re is no?+ 9 ! composition ( ,virol to ju/ify ! claims made = x4 ,! judgm5t & recomm5dations ( ! fir/ ref]ee foll[ f ! facts & mu/ be accept$ by ! ,c\ncil40 ,! ,c\ncil direct$ t ! previ\sly prep>$ report be all[$ to /& & t x be publi%$ along ) a suitable ref]5ce to ! report ( ! second ref]ee4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,feb4 #bj1 #aiae47 ,,"p ,,ii ,,contributions ,,f ,,! ,,*emical ,,laboratory ,,anusol ,,hemorrhoidal ,,suppositories,,ao ,w4 ,a4 ,puckn] & ,l4 ,e4 ,w>r5 ,,ao ,see also ,anusol ,suppositories1 p4 #bhj4 ,an ab/ract ( an article conc]n+ 8anusol suppositories0 0 publi%$ 9 ,! ,j\rnal1 ,jan4 #bc1 #aiji4 ,?is gave ! results ( an analysis by a =eign *emi/1 ,j4 ,f4 ,suyv]1 :i* 7 to ! effect t 8anusol suppositories0 conta9$ no 8anusol40 ,s*]+ ,glatz1 ! ,am]ican ag5ts = 8anusol0 suppositories1 took exceptions to ! ab/ract1 ask$ t ,! ,j\rnal retract1 & submitt$ ! f9d+s ( a *emi/ 9 support ( _! claim t ! suppositories d conta9 8anusol40 ,to det]m9e ! composition ( 8anusol hemorrhoidal suppositories0 z !y are f\nd on ! ,am]ican m>ket1 trade packages 7 pur*as$ 7,april #f1 #aiji7 & submitt$ to exam9ation#ij 9 ! ,association's laboratory4 #ij ,details ( ! quantitative analysis ( 8,anusol ,hemorrhoidal ,suppositories0 appe> 9 ! annual report = #aiji ( ! ,*emical ,laboratory ( ! ,am]ican ,m$ical ,association4 ,accord+ to ! claims ( ! manufactur]s1 #ab suppositories conta93 8,anusoli #g4e grams4 8,z9c oxid #f4j grams 8,balsam ,p]uv #a4e grams 8,ol4 !obrom #ai4j grams 8,ungt4 c]at #b4e grams0 ,calculat$ to p]c5tages ! =mula reads3 ,anusoli #bj4ed p] c5t4 ,z9c oxid #af4dd p] c5t4 ,balsam ,p]uv #d4aa p] c5t4 ,ol4 !obrom #eb4jf p] c5t4 ,ungt4 c]at #f4he p] c5t4 ,:5 ?is product 0 submitt$ to ! ,c\ncil "s "t ago1 ,s*]+ ,glatz /at$ t1 accord+ to ! manufactur]1 8anusol0 is ! 8iodo resorc9 sulphonate ( bismu?1 hav+ ! foll[+ rational =mula3 ,c#f;,h#b;,,iso#b4,o7,,oh7#bc;,bi4 ,9 ! meta-dioxyb5zol ,c#f;,h#d7,,oh7#b1 ! resorc91 "o ,h has be5 replac$ by "o ,i1 & = ano!r ,h ! sulfonic-acid gr\p ,,s#b-,,oh has be5 sub/itut$1 s t meta-dioxyb5zol is trans=m$ into ,c#f;,h#b;,,iso#b-,,oh7,,oh7#b4 ,9 ! sulfonic acid ! ,h ( ,,oh is replac$ by ,bi &1 z ,bi is trival5t ! above rational =mula results40 ,accord+ to ?is =mula 8anusol0 %\ld conta93 ,iod9 #cb4ii p] c5t4 ,sulphur #h4cd p] c5t4 ,bismu? #ah4jg p] c5t4 ,& ! 8anusol0 suppositories %\ld conta93 ,iod9 #f4gg p] c5t4 ,sulphur #a4ga p] c5t4 ,bismu? #c4ga p] c5t4 ,exam9ation %[$ t ! suppositories conta9 ab\t #j4jh p] c5t4 iod91 or #a4b p] c5t4 ( ! am\nt claim$2 #j4bh p] c5t4 sulphur1 or #af4c p] c5t4 ( :at is claim$2 #j4ga p] c5t4 bismu?1 or #ai p] c5t4 ( :at is claim$2 & z9c equival5t to #af4e p] c5t4 z9c oxid1 or ab\t #ajj p] c5t4 ( claim4 ,f ! /&po9t ( ! iod9 cont5t alone1 assum+ t all ( ! iod9 f\nd is pres5t 9 ! =m ( 8anusol10 ! results ( ! exam9ation ( ! product 7z f\nd on ! ,am]ican m>ket7 v]ifies1 = all practical purposes1 ,suyv]'s /atem5t t 8anusol suppositories conta9 no anusol10 = ! quantity ( iod9 pres5t is s m9ute 7ab\t #a_/hb ( t requir$ by ! =mula7 z to be unwor?y ( s]i\s consid]ation4 ,! pres5ce ( sulphid 9 appreciable am\nts 0 demon/rat$ %[+ t ! sulphur is pres5t1 at lea/ 9 "p1 9 ! =m ( sulphid & n z sulphonate z is claim$4 ,9 a measure1 too1 ?is is 9 accord ) ! f9d+s ( ,suyv]1 :o conclud$ t1 9 ! product :i* he exam9$1 ! bismu? 0 pres5t 9 ! =m ( sulphid4 ,! proportions ( sulphur & ( bismu? 7respectively ab\t #a_/f & #a_/e ( ! requir$ am\nts7 indicate /ill fur!r t ! product is n all t x is claim$ to be4 ,a specim5 submitt$ by ,s*]+ ,glatz to ! ,c\ncil two ye>s ago conta9$ #j4ii p] c5t4 iod91 or #a4c p] c5t4 ( ! am\nt claim$2 #j4bc p] c5t4 sulphur1 or #ac4d p] c5t4 ( ! claim$ am\nt2 & #j4eb p] c5t4 bismu?1 or #ad p] c5t4 ( :at is claim$ by ! =mula4 ,s9ce ! above det]m9ations 7 made ano!r specim5 ( ,anusol ,hemorrhoidal ,suppositories 0 receiv$ f ,s*]+ ,glatz1 ,july #af1 #aiji4 ,?is sample 0 f\nd to conta9 ab\t3 #j4jge p] c5t4 iod91 or #a4a p] c5t4 ( ! am\nt requir$ by ! =mula2 #j4bfe p] c5t4 ( sulphur1 or #ae4e p] c5t4 ( ! requirem5t & #j4hh p] c5t4 bismu?1 or #bc4g p] c5t4 ( ! requir$ am\nt4 ,x w ?us be se5 t ! composition ( ! olde/ specim5 & also t ( ! specim5 rec5tly s5t1 corresponds 9 a g5]al way to t ( ! "o fir/ exam9$4 ,:e!r judgm5t be bas$ on ! det]m9ation ( ! bismu?1 ! sulphur or ! iod91 ! results j giv5 cle>ly %[ t ! claims made conc]n+ ! composition ( 8,anusol ,hemorrhoidal ,suppositories0 are n sub/antiat$ by ! facts4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,oct4 #b1 #aiji47 ,,aromatic ,,dige/ive ,,tablets ,w4 ,a4 ,puckn] & ,l4 ,e4 ,w>r5 ,x has be5 amply demon/rat$#ia t peps9 & pancreat91 :5 9 solution1 mutually de/roy ea* o!r2 if ! solution be acid1 ! peps9 de/roys ! pancreat92 if alkal9e1 ! pancreat9 de/roys ! peps94 ,by us+ ! *>act]i/ic effect ( peps9 on proteids 9 acid m$ium & t ( pancreat9 on proteids & />*es 9 an alkal9e solution x c readily be demon/rat$ t comm]cial liquid prep>ations label$ z conta9+ bo? ( ^! f]m5ts actually conta9 only "o f]m5t4 ,!y are misbr&$4 #ia ,u4,s4 ,ph>macopeia1 #h? revision1 p4 #ccd4 ,besides ! liquid a goodly numb] ( solid prep>ations1 *iefly tablets1 conta9+ peps9 & pancreat9 are (f]$ to ! pr(ession4 ,among ^! are tablets consi/+ simply ( peps9 & pancreat94 ,s9ce peps9 & pancreat9 int]act only :5 9 solution1 x is q possible to prep>e tablets :i* conta9 ^! f]m5ts4 ,! use ( su* tablets is1 h[ev]1 unsci5tific1 s9ce "o or ! o!r ( ! f]m5ts is de/roy$ :5 x comes 9 contact ) ! fluids ( ! dige/ive tract4 ,9 addition to simple tablets conta9+ peps9 & pancreat9 only !re is at pres5t a ho/ ( 8dige/ive tablets0 on ! m>ket4 ,among ^! are "s :i* mu/ be class$ ) ! 8dige/ive impossibilities0 7,reports ( ! ,c\ncil on ,ph>macy & ,*emi/ry1 #aiaj1 ,vol4 #a1 p4 #da74 ,! prep>ations ref]r$ to are tablets claim$ to conta9 peps91 pancreat91 dia/ase1 hydro*loric acid & lactic acid4 ,:5 x is consid]$ t ! ,unit$ ,/ates ,ph>macopeia def9es hydro*loric acid z 8a liquid compos$ ( #ca4i p] c5t4 by weight ( absolute hydro*loric acid 7,h,cl #cf4af7 & #fh4a p] c5t4 ( wat]10 i4 e41 a solution ( hydrog5 *lorid1 a gas1 9 wat]1 x w\ld at fir/ appe> t ! incorporation ( any appreciable quantity ( hydro*loric acid 9 tablets w\ld be impracticable4 ,hydro*loric acid1 h[ev]1 possesses to a limit$ ext5t ! prop]ty ( comb9+ loosely ) prote9 sub/ances s t x becomes possible to br+ ab\t its comb9ation ) peps9 & simil> sub/ances to =m comp\nds :i* are relatively /able at ord9>y temp]atures4 ,because ( ! volatility ( ! free acid & its limit$ comb9+ p[] ) prote9 sub/ances 7#ajj gm4 boil$ beef comb9e ) #b gm4 absolute hydro*loric acid#ib71 ! quantity ( acid 9 any tablet c nev] be l>ge1 mu* less ?an suffici5t to be ( any !rapeutic value4 #ib ,hemmet]1 ,diseases ( ! ,/oma*1 ,edition #c1 p4 #bej4 ,a numb] ( firms (f] 8dige/ive tablets0 = sale hav+ =mulas ( :i* ! foll[+ may be consid]$ typical3 ,sac*4 ,peps9 #d gra9s ,pure ,pancreat9 #a gra9 ,dia/ase #a_/d gra9 ,aromatic ,p[d] #a_/d gra9 ,lactic ,acid #a_/h gra9 ,hydro*loric acid #a_/h gra9 ,"s manufactur]s use ,unit$ ,/ates ,ph>macopeia peps9 9 place ( ! sac*>at$ article2 o!rs d n give ! exact quantities ( hydro*loric acid :i* _! product is suppos$ to conta91 b make use ( ! indef9ite expression 8q4 s420 /ill o!rs /ate m]ely t hydro*loric acid is pres5t1 b make no claim :atev] conc]n+ ! quantity4 ,f purely !oretical consid]ations x is possible t ! tablets ref]r$ to might conta9 appreciable am\nts ( hydro*loric acid4 ,s9ce ! =mulas = "s ( ! tablets furni% no in=mation conc]n+ ! cont5t ( hydro*loric acid1 x seem$ wor? :ile to det]m9e ! quantity1 if any1 actually pres5t 9 "s ( ! tablets on ! m>ket4 ,accord+ly a trade package ( 8dige/ive aromatic tablets10 z put up "u ! label ( ea* ( six ,am]ican manufactur]s1 0 pur*as$ & submitt$ to exam9ation 9 ! ,association laboratory4 ,qualitative te/s made on specim5s f ea* br& ( tablets demon/rat$ ! abs5ce ( uncomb9$ hydro*loric acid 9 ea*4 ,fur!r te/s#ic %[$ t hydro*loric acid 9 prote9 comb9ation 0 pres5t ess5tially 9 ! am\nts claim$ 9 ?ree ( ! specim5s4 ,9 two ( ! o!rs hydro*loric acid 0 entirely abs5t2 9 ! rema9+ "o only ! m]e/ traces ( hydro*loric acid c\ld be f\nd4 #ic ,details ( ?is analysis appe> 9 ! annual report = #aiaj ( ! ,*emical ,laboratory ( ! ,am]ican ,m$ical ,association4 ---------------------------------------- - ,h4 ,k4 ,,mul=d ,,company 8,,dige/ive ,,aromatic0 8,peps91 ,sac*4 #d gra9s 8,pancreat9 #a_/b gra9 8,dia/ase #a_/af gra9 8,acid ,lactic #a_/h gra9 8,acid ,hydro*loric #a_/h gra9 8,aromatic ,p[d] #a_/d gra9 8,dose3 #a or #b tablets40 ---------------------------------------- - ,9 ! above =mula ea* tablet is said to conta9 #a_/h gra9 hydro*loric acid4 ,?is am\nt is equival5t to #j4jjbehd gm4 7#a_/be gra97 absolute hydro*loric acid4 ,analysis demon/rat$ t ea* tablet conta9s ab\t #j4jjbfg gm4 hydro*loric acid 7absolute ,h,cl7 or ess5tially ! am\nt claim$4 ,! av]age dose ( dilut$ hydro*loric acid ,unit$ ,/ates ,ph>macopeia is #a c4c41 equival5t to #j4ajdi gm4 absolute hydro*loric acid4 ,to obta9 ?is quantity f ! above prep>ation ! pati5t w\ld be requir$ to swall[ m ?an ?ree doz5 ( ! tablets4 ---------------------------------------- - ,,wm4 ,s4 ,,m]rell ,,*emical ,,company 8,,dige/ive ,,aromatic1 #e ,,gra9s0 8,peps9 #hj p>ts 8,pancreat9 #aj p>ts 8,dia/ase #a "p 8,acid ,lactic #a "p 8,acid ,hydro*loric #c p>ts 8,aromatic ,p[d] #e p>ts0 ---------------------------------------- - ,calculation %[s t ea* tablet %\ld conta9 ab\t #j4jjca gm4 ( absolute hydro*loric acid4 ,! analysis indicat$ t ea* tablet conta9s ab\t #j4jjcj gm4 hydro*loric acid 7absolute ,h,cl7 9 prote9 comb9ation1 or practically ! am\nt claim$4 ,"o ph>macopeial dose ( hydro*loric acid is conta9$ 9 #ce ( ! tablets4 ---------------------------------------- - ,,p>ke1 ,,davis ,,company 8,,dige/ive ,,aromatic0 8,sac*>at$ ,peps9 #d gra9s 8,pure ,pancreat9 #a gra9 8,dia/ase #a_/d gra9 8,aromatic ,p[d] #a_/d gra9 8,lactic ,acid4 8,hydro*loric ,acid4 8,dose3 #a to #c tablets40 ---------------------------------------- - ,*lorid is pres5t 9 small am\nts1 b quantitative exam9ation indicat$ t hydro*loric acid1 ei!r free or 9 prote9 comb9ation is abs5t4 ,an ammonium salt is pres5t 9 small quantities4 ---------------------------------------- - ,,%>p ,,dohme 8,,dige/ive ,,aromatic0 8,peps91 ,sac*41 ,u4 ,s4 ,p4 #d gra9s 8,pancreat91 pure #a gra9 8,dia/ase #a_/d gra9 8,aromatic ,p[d] #a_/d gra9 8,lactic ,acid q4 s4 8,hydro*loric ,acid q4 s40 ---------------------------------------- - ,small quantities ( *lorid are pres5t4 ,quantitative exam9ation indicat$ t hydro*loric acid 9 prote9 comb9ation is pres5t only 9 v small am\nts1 ea* tablet conta9+ b ab\t #j4jjjcd gm4 ( absolute acid1 or ab\t #j4cd p] c5t4 ( ! ph>macopeial dose4 ,ammonia is abs5t4 ,inasmu* z m ?an #cjj ( ^! tablets w\ld be requir$ to furni% a ph>macopeial dose ( hydro*loric acid1 ?is firm's int]pretation ( ! expression 8q4 s40 w\ld prove int]e/+4 ---------------------------------------- - ,,truax1 ,,gre5e ,,company 8,,syn]gia0 ---------------------------------------- - 8,syn]gia0 is claim$ to be compos$ ( 8peps91 pancreat91 veg4 dia/ase1 lactic acid1 hydro*loric acid & aromatics2 dose1 #a to #c tablets40 ,! specim5 conta9$ no hydro*loric acid1 ei!r free or 9 prote9 comb9ation4 ,a trace ( ammonia & small quantities ( *lorid 7 f\nd4 ---------------------------------------- - ,,! ,,fraske ,,tablet ,,company 8,peps9 ,sac*4 #hj p>ts 8,pancreat91 ,pure #aj p>ts 8,dia/ase #a "p 8,lactic ,acid #a "p 8,hydro*loric ,acid #c p>ts 8,aromatic ,p[d] #f p>ts 8,dose3 #a to #b tablets4 8,ea* tablet repres5ts 7#e7 gra9s ( ! above mixture40 ---------------------------------------- - ,accord+ to ! =mula hydro*loric acid 7#ca4i p] c5t4 absolute ,h,cl7 repres5ts #c p>ts 9 #aja ( ! prep>ation f :i* ! tablets are made4 ,ea* tablet 7conta9+ #e gra9s ( ! mixture7 %\ld h #j4jjcjg gm4 absolute hydro*loric acid4 ,analysis %[$ t ea* tablet conta9s hydro*loric acid 9 prote9 comb9ation equival5t to an av]age ( #j4jjcjff gm4 absolute hydro*loric acid1 or ess5tially ! am\nt claim$4 ,x w\ld be necess>y to give #cd tablets to adm9i/] a ph>macopeial dose ( hydro*loric acid4 ,editorial ,note3 ,! above indicates t ! use ( su* tablets is irrational1 unsci5tific & t x %\ld be condemn$4 ,! only con/itu5t ( ^! tablets1 o!r ?an ! aromatics1 :i* might possibly be ( b5efit 9 /oma* tr\bles1 is ! peps94 ,b ev5 if x be assum$ t ! dia/ase & pancreat9 c\ld ex]t _! *>act]i/ic effects1 _! aid to dige/ion 7metabolism7 w\ld be b slight1 because _! am\nts 9 ! tablets are too small to be ( any value4 ,x is claim$ t ! tablets conta9 dia/ase 9 am\nts v>y+ f #a_/bj to #a_/d gra94 ,assum+ ! dia/ase us$ to be ( fir/-class quality1 i4 e41 capable ( conv]t+ #bjj times its own weight ( />* into soluble products1 ! quantity ( "o tablet w\ld be capable at ! mo/ ( dige/+ b f #aj to #ej gra9s ( />*1 an am\nt equal at ! mo/ to b a small spoonful ( oatmeal or a v da9ty bite ( bread4 ,9 ! same way ! quantity ( pancreat9 is insuffici5t to be ( any mat]ial aid 9 dige/ion %\ld x 9 "s way escape de/ruction 9 ! /oma* & /ill reta9 its full activity :5 x rea*es ! alkal9e juices ( ! inte/9es4 ,"o gra9 ( pancreat9 ( full ,unit$ ,/ates ,ph>macopeia /r5g? w dige/ only #be gra9s ( />* or ! proteids 9 ab\t #ajj c4c4 ( milk4 ,sac*>at$ peps91 :i* 0 =m]ly (ficial1 0 requir$ to dige/ #cjj times its own weight ( moi/ egg album91 :ile ! peps9 t is n[ (ficial is requir$ to dige/ t5 times t am\nt1 or #c1jjj times its own weight4 ,x is evid5t1 !re=e1 t ! tablets %\ld conta9 suffici5t peps9 to dige/ appreciable am\nts ( prote94 ,no intellig5t physician w\ld prescribe ^! tablets simply = ! peps9 !y conta9 or are suppos$ to conta92 if he want$ to give peps9 he w\ld prescribe ! drug 9 ! simple =m4 ,cl9ical exp]i5ce has %[n t 9 ! majority ( cases ( s-call$ dyspepsia ! /oma* cont5ts conta9 too mu* r ?an too little hydro*loric acid1 & :]ev] !re is a suffici5cy ( acid !re is usually no decrease 9 ! secretion ( peps94 ,9 _m ( su* cases1 too1 dige/ion is normal1 or ev5 m active ?an normal1 b ev5 :5 x is imp]fect !re is seldom any lack ( peps94 ,insuffici5t dige/ive p[] is mo/ (t5 due to a defici5cy ( hydro*loric acid & n to lack ( peps9 9 ! /oma* cont5ts4 ,9 ! tablets "u consid]ation1 h[ev]1 hydro*loric acid is pres5t--if at all--9 ! mo/ ridicul\sly m9ute quantities2 quantities t are s small z to preclude any !rapeutic effect except t due to ! psy*ic elem5t4 ,^! tablets1 ) _! six or m +r$i5ts1 are typical 8%otgun prescriptions40 ,su* prescriptions cat* ! un?9k+ doctor z well z ! self-drugg+ public1 =1 :ile cl9ical exp]i5ce & physiologic exp]im5ts h demon/rat$ t ! old ideas reg>d+ ! value ( ^! dige/ives & f]m5ts 7 errone\s1 ! public & _m memb]s ( ! m$ical pr(ession /ill seem to be influ5c$ by ! old !ories4 ,9 conclusion we mu/ n lay all ! blame on ! manufactur+ firms = supply+ ^! absurd comb9ations2 ! physician :o prescribes !m %\ld assume a l>ge %>e ( x4 ,if ! doctors did n use !m ! manufactur+ conc]ns w\ld soon /op putt+ !m on ! m>ket4 ,we hope1 h[ev]1 t ^? manufactur+ conc]ns t l to be class$ z reputable w cease to disgrace _! catalogues ) :at !y "k to be !rapeutic absurdities4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,aug4 #bj1 #aiaj47 ,,burnham',s ,,soluble ,,iod9,,ap ,w4 ,a4 ,puckn] & ,a4 ,h4 ,cl>k ,,ap ,see also report on ,burnham's ,soluble ,iod9e1 p4 #aaj ,burnham's ,soluble ,iod91 accord+ to ! manufactur]s1 is "o ( ! mo/ notewor?y 8discov]ies0 ( ! age4 ,! adv]tisem5ts aim to create an impression t :ile ! product conta9s iod91 pure & simple1 yet by "s secret process ?is elem5t has be5 s *ang$ z no long] to possess its usual prop]ties4 ,! ,burnham ,soluble ,iod9 ,company makes su* extravagant claims = its product & gives su* wide publicity to ^! claims t x seem$ advisable1 9 ! int]e/s ( ! pr(ession1 to det]m9e ! nature ( ! prep>ation4 ,its exam9ation 0 accord+ly tak5 up 9 ! laboratory ( ! ,am]ican ,m$ical ,association4 ,f ! analysis1 we conclude t ,burnham's ,soluble ,iod9 is a solution ( iod9 9 alcohol made miscible ) wat] by ! pres5ce ( "s iodid4 ,wilb]t#id & o!r inve/igators h arriv$ at practically ! same conclusion4 #id ,proc4 ,am4 ,ph>m4 ,assn41 #aijc1 li1 #dji4 ,:atev] ! secret process1 h9t$ at 9 ! adv]tisem5ts1 by :i* ?is prep>ation is evolv$1 ! fact rema9s t :5 "o prescribes ,burnham's ,soluble ,iod91 "o is prescrib+ iod91 toge!r ) an iodid1 ! nature ( :i* is h>d to det]m9e4 ,! iodid is n pres5t z potassium iodid1 nor1 entirely1 at lea/1 z hydrog5 iodid 7hydriodic acid71 b ?is is ( slight importance comp>$ ) ! fact t x is a solution 9 alcohol ( free iod9 & an iodid1 & !re=e is ess5tially ! same z ,lugol's solution4 ,! am\nt ( iod9 f\nd corresponds approximately to #c gm4 ( free iod9 & #b gm4 ( comb9$ iod9 9 #ajj c4c4 ( ! solution4 ,lugol's solution conta9s #e gm4 free iod91 & #aj gm4 potassium iodid 9 #ajj c4c4 ,,burnham',s ,,soluble ,,iod9 ,,tablets ,burnham's ,soluble ,iod9 ,tablets are light br[n compress$ tablets1 /amp$ ) ! lett]s ,b4 ,s4 ,i4 9 monogram4 ,ea* tablet is said to conta9 #c m9ims ,burnham's ,soluble ,iod94 ,! av]age weight ( ea* tablet 0 f\nd to be #j4cebf gm42 s9ce ,burnham's ,soluble ,iod9 0 f\nd to h a specific gravity ( 4#hebg & to conta9 #d4e p] c5t4 total iod91 ! tablets %\ld conta9 approximately #b4c p] c5t4 total iod91 ab\t "o-half to two-?irds ( :i*1 dep5d+ on ! condition ( ! 8,soluble ,iod90 f :i* !y are made1 %\ld be free iod94 ,in/ead ( ?is1 only #j4cag p] c5t4 free iod9 & #a4eg p] c5t4 total iod9 0 f\nd4 ,analysis %[s t ,burnham's ,soluble ,iod9 tablets conta9 approximately "o-f\r? ! am\nt ( free iod9 & approximately two-?irds ! am\nt ( total iod9 :i* %\ld be conta9$ !re9 if1 9 accordance ) ! label1 ea* tablet conta9s #c m9ims ( ,burnham's ,soluble ,iod94 ,,comm5t ,! lit]ature put out by ! ,burnham ,soluble ,iod9 ,company is 9 itself en\gh to condemn ! products x adv]tises4 ,! mu* emphasiz$ /atem5t ( ! company t 8,some?+ _h to be done2 & ,burnham's ,soluble ,iod9 is t :i* has be5 done0 fulfils1 9 its blatant ass]tiv5ess1 all ! requirem5ts ( no/rum adv]tis+4 ,! results ( ! analyses are n1 !re=e1 a surprise4 ,secrecy is j z ess5tial today to ! successful exploitation ( ?is class ( propriet>ies z x 0 be=e ! dem& = =mulas became s univ]sal4 ,! requirem5t ( publicity is evad$1 !re=e1 9 "o ( two ways3 ,ei!r a =mula is giv5 :i* is false1 or at lea/ mean+less1 or else ! claim is made t ! me?od ( prep>+ ! product is a unique & rem>kable secret t is possess$ only by ! manufactur]s4 ,! ,burnham ,soluble ,iod9 ,company uses ! latt] device4 ,mean:ile1 physicians w be p]fectly ju/ifi$ 9 view+ ) suspicion all claims bas$ on su* conspicu\sly unsci5tific premises1 m especially s :5 ^! claims fail to f9d sub/antiation on c>eful & pa9/ak+ analyses4 ,9 brief1 :5ev] ! physician wi%es to adm9i/] free iod91 ,lugol's solution 7,liquor ,iodi ,compositus1 ,u4 ,s4 ,p41 ,physician's ,manual1 page #hd7 is an inexp5sive & p]fectly available prep>ation4--7,f ! ,j\rnal ,a4 ,m4 ,a41 ,m>* #bh1 #aijh47 8,,hydrocyanate ,,( ,,iron--,,tild50 ,w4 ,a4 ,puckn] & ,w4 ,s4 ,hilp]t ,among ! _m inquiries receiv$ reg>d+ ! composition ( secret rem$ies 0 "o 9 ref]5ce to 8,hydrocyanate ( ,iron0 manufactur$ by ! ,tild5 ,company1 ,new ,lebanon1 ,n4 ,y4 ,?is prep>ation is adv]tis$ z be+ 8unexcell$ z a rem$y = epilepsy1 hy/]ia1 *orea1 neura/h5ia1 locomotor ataxia1 neuralgia1 migra9e1 anemic heada*es1 & all convulsive or reflex neuroses dep5d5t on impairm5t ( ! bra9 or sp9al cord40 ,x is also said to be 8valuable 9 ut]9e reflex neuroses due to conge/ion2 9 am5orrhea due to anemia & *lorosis & suppress$ m5/ruation40 ,! t]m 8hydrocyanate ( iron0 is an unfamili> "o & is n f\nd 9 any available ref]5ce "w on *emi/ry4 ,?9k+ t ! t]m might h be5 loosely appli$ to f]rocyanid ( iron1 or ,prussian blue 7a comp\nd once sugge/$ = epilepsy1 b long ago consid]$ useless71 ! correspond5t wrote to ! manufactur]s ask+ if su* 7 ! case4 ,! ,tild5 ,company answ]$3 8444 our prep>ation ,hydrocyanate ( ,iron is n ,prussian blue 9 any s5se ( ! ^w4 ,prussian blue has no curative prop]ties z appli$ to all =ms ( epilepsy4 ,prussian blue is ,f]rocyanid ( ,iron :ile our prep>ation is ,hydrocyanate ( ,iron40 ,! only /atem5ts 9 ! ,tild5 ,company's adv]tis+ matt] reg>d+ ! composition ( hydrocyanate ( iron are ! foll[+3 8,hydrocyanate ( ,iron 7,tild5's7 is a correct & sci5tific comb9ation ( well kn[n pr9ciples40 8,hydrocyanate ( ,iron 7,tild5's7 comb9es well kn[n prop]ties ( f]rug9\s salts ) ! s$ative action ( ,hydrocyanic acid40 ,! la/ /atem5t w\ld lead "o to expect ! pres5ce ( available iron & cyanog5 ions4 ,9 fact1 ! inf]5ce to be drawn f all ! company's 8lit]ature0 is t 8hydrocyanate ( iron0 is a def9ite *emical comp\nd 9 ! same s5se z is f]rocyanid ( iron1 & t inf]5ce is /ill fur!r borne out 9 ! lett] to our correspond5t4 ,?is be+ ! case1 ! ,tild5 ,company 0 aga9 writt5 to & ask$ = ! *emical =mula ( 8hydrocyanate ( iron10 ) ! foll[+ result3 8,reply+ to y\r inquiry reg>d+ ! =mula ( ,hydrocyanate ( ,iron we beg to /ate ! composition ( ?is prep>ation is a trade secret & we !re=e d n c>e to furni% ! desir$ in=mation40 ,?is reply v]ifi$ ! op9ion already =m$ t 8hydrocyanate ( iron0 is a secret prep>ation4 ,its analysis 0 !n tak5 up 9 ! ,association's laboratory4 ,,exam9ation ,,( ,,! ,,tablets ,! product appe>s on ! m>ket 9 c>tons said to conta9 "o ounce ( "o-gra9 tablets4 ,on ! c>tons1 9 addition to ! "n ( ! prep>ation & ! "n & address ( ! manufactur]s1 are ! names ( diseases = :i* x is recomm5d$4 ,! tablets1 9 ! specim5s analyz$1 7 d>k blue1 r h>d & slightly bitt] 9 ta/e & _h an av]age weight ( #j4achb gm41 or ab\t #b gra9s4 ,!y 7 f\nd to be practically insoluble 9 wat] & dilute m9]al acids2 aque\s oxalic acid solution p>tially dissolv$ !m1 yield+ a blue solution4 ,boil+ ) alkali hydroxid solution decompos$ ! tablets1 yield+ iron 9 an insoluble =m & a solution ( alkali f]rocyanid1 z demon/rat$ by ! appe>ance ( a deep blue precipitate on ! addition ( f]ric *lorid solution4 ,! portion insoluble 9 alkali :5 boil$ ) hydro*loric acid yield$ a solution conta9+ iron1 approximately equival5t to #ej p] c5t4 ,prussian blue4 ,^! prop]ties are all *>act]i/ic ( ,prussian blue1 &1 tak5 toge!r1 id5tify ,prussian blue z a con/itu5t ( 8hydrocyanate ( iron 7,tild5740 ,! insoluble residue f ! iron det]m9ation possess$ ! prop]ties & con/itu5ts ( talc & con/itut$ practically "o-half ( ! tablets4 ,extraction ( ! tablets ) *lor(orm or e!r 9 ! pres5ce ( ammonium hydroxid yield$ a small am\nt ( organic mat]ial :i* conta9$ bodies hav+ ! prop]ties (1 & respond+ to te/s =1 qu99 or c9*ona alkaloids & caffe94 ,! pres5ce ( a salicylate 0 also indicat$4#ie #ie ,details ( ! quantitative analysis ( 8,hydrocyanate ( ,iron--,tild50 appe> 9 ! annual report = #aiji ( ! ,*emical ,laboratory ( ! ,am]ican ,m$ical ,association4 ,f ! analysis x is conclud$ t 8hydrocyanate ( iron 7,tild570 is ess5tially a mixture ( approximately equal p>ts ( talc & ,prussian blue1 conta9+ traces ( organic matt] hav+ ! g5]al prop]ties ( alkaloids4 ,comm5t3 ,:5 a firm exploits an ab&on$ rem$y = s hopeless a disease z epilepsy "u a "n n kn[n to *emi/ry & ) a false repres5tation ( its ph>macologic qualities1 su* action may rightly be assum$ to %[ ignorance or worse4 8,hydrocyanate ( iron10 if x means any?+1 means ! cyanid ( iron1 b ! prep>ation put out "u t "n is1 accord+ to our *emi/s1 n cyanid ( iron1 b ! f]rocyanid ( iron commonly kn[n z ,prussian blue4 ,?is sub/ance has be5 tri$ = epilepsy & ab&on$4 ,yet ! firm recomm5ds x z a 8pe]less rem$y0 = ?is disease3 8,! ,tild5 ,company holds ! key to ! situation 9 ! treatm5t ( epilepsy4 ,we h ! rem$y t does ! "w40 ,n t epilepsy is ! only disease = :i* ?is hypo!tical *emical comp\nd may be prescrib$4 ,torticollis has be5 8successfully treat$ ) hydrocyanate ( iron40 ,9 *orea1 we are told 8a ri*] & bett] blood supply0 %\ld be furni%$ ! n]v\s & vascul> sy/em & 8! irritation ( ! motor c5t]s0 mu/ be allay$4 8,hydrocyanate ( iron s]ves admirably to accompli% bo? ( ^! purposes4 ,x c>ries ! hemoglob9 to ! blood 9 its mo/ easily assimilable =m & its hydrocyanic acid possesses rem>kable s$ative p[]s44440 ,x is n possible = x to h any value 9 anemia because ( its insolubility1 yet we are told3 8,9 conditions m>k$ by pov]ty ( ! blood produc+ anemia or *lorosis1 react+ on ! n]v\s sy/em & call+ = a *alybeate1 hydrocyanate ( iron 7,tild5's7 takes a front rank among ! rem$ies ( ?is class1 comb9+ z x does ! blood enri*+ qualities ( f]rum ) ! s$ative action ( hydrocyanic acid40 ,z ,prussian blue yields no appreciable quantity ( hydrocyanic acid "u ! conditions exi/+ 9 ! animal organism1 8! s$ative action ( hydrocyanic acid0 mu/ be z hypo!tical z ! *alybeate prop]ties attribut$ to x4 ,x is /range t a manufactur]1 9 introduc+ a new *emical comp\nd1 %\ld h to assure 8 cu/om]s t x 8conta9s no opium or alkaloid ( t drug1 coca91 *loral hydrate1 conium or any ( ! bromids40 ,imag9e a firm putt+1 let u say1 potassium iodid--a def9ite *emical comp\nd--on ! m>ket & solemnly gu>antee+ t x conta9$ no coca9 or *loral hydrate6 ,w\ld ! ,tild5 ,company ( tw5ty-five ye>s ago h s]v$ su* m5tal pabulum 9 its adv]tis+ matt]8 ,"o w\ld ?9k t ! dictates ( common humanity w\ld protect ! un=tunate epileptic f ! ma*9ations ( ! no/rum mak]1 especially f ! exploitation ( a rem$y t has be5 tri$ & f\nd want+4 ,a no/rum1 h[ev]1 m]ely has to measure up to "o /&>d3 ,w x pay8 ,meet+ ?is requirem5t no?+ else matt]s4--7,f ! ,j\rnal ,a4 ,m4 ,a41 ,june #ai1 #aiji47 ,,hymosa ,w4 ,a4 ,puckn] & ,w4 ,s4 ,hilp]t ,frequ5t reque/s = in=mation reg>d+ ! composition ( hymosa1 manufactur$ by ! ,walk] ,ph>macal ,co41 ,/4 ,l\is1 & a p]usal ( ! ext5sive & no/rum-l adv]tis+ ! product is receiv+1 made a *emical exam9ation ( ?is prep>ation seem desirable4 ,if ! label is to be believ$1 hymosa has be5 ( use 9 8acute & *ronic muscul> & articul> rheumatism1 g\t1 sciatica1 lumbago1 pleurodynia & neuralgia1 :e!r due to uric acid dia!sis or n 4440 ,! composition ( hymosa z giv5 by ! proprietors is set =? 9 ! foll[+ /atem5t3 8444 ,hymosa1 9 :i* ! rem$ies ,frangula1 ,actea ,spicata1 ,/ell>ia ,m$ia1 ,franciscea ,uniflora1 ,rhus ,toxicod5dron1 ,passiflora ,inc>nata1 ,phytolacca ,dec&ra & ,e*9acea ,angu/ifolia are comb9$ 9 ! proportions :i* exp]i5ce has %[n w obta9 ! quicke/ & be/ results )\t any ( ! /oma* & he>t complications s (t5 foll[+ ! adm9i/ration ( salicylic acid40 8,conta9s no ,salicylic ,acid40 ,?us ! explicit /atem5t is made t hymosa conta9s c]ta9 vegetable drugs 7mo/ ( !m obsolete & valueless7 & t x does n conta9 salicylic acid4 ,by inf]5ce ! claim repeat$ly is made t ! no/rum does n conta9 any salicylates4 8444 ,hymosa has a*iev$ mo/ rem>kable results 9 ov]com+ rheumatism 9 cases :]e salicylates h be5 tri$ 9 va9 4440 8,salicylic acid 0 n successful 9 ?is case ( rheumatism ( ! /oma*40 8,negative results f salicylates--,hymosa cures40 8444 ! salicylates didn't help8 ,!n we mu/ try ,hymosa40 ,/ill h>p+ on ! undesirability ( salicylates & ! value ( hymosa ! adv]tis+ pamphlets /ate3 8,salicylic ,acid ,replac$4 ,! ,use ( ,?is ,dang]\s ,ag5t 9 ,rheumatism ,obviat$40 8,x seems t ! use ( ! dang]\s & ineffective salicylic acid w soon be giv5 up & hymosa take its place40 8,=m] me?ods ( treat+ rheumatism 444 h be5 v unsatisfactory 444 because ( ! he>t & /oma* difficulties br\ght on by salicylates ( :i* mo/ rheumatism rem$ies are compos$40 8,c\ld n tol]ate ! salicylates40 ,f9ally 9 a lett] issu$ to physicians we are told3 8444 y w f9d hymosa to possess prompt & positive curative action ) ! additional advantage ( avoid+ ! he>t & /oma* complications1 :i* ! salicylates too (t5 cause40 ,x is evid5t f ! above quotations1 9 :i* ! salicylates are d5\nc$ specifically or by implication1 & f ! label :i* /ates t no salicylic acid is pres5t1 t ! exploit]s ( ! no/rum delib]ately int5d$ to give ! impression t hymosa is free f salicylates or salicylic acid & conta9s only ! vegetable or plant drugs enum]at$4 ,! v fact t ! proprietors make su* repeat$ ef=ts to give ! impression t hymosa is free f salicylates is 9 itself suffici5t to ar\se suspicion & h5ce 9 ! exam9ation p>ticul> att5tion 0 giv5 to ! detection ( salicylic acid or salicylates ) ! foll[+ results3 ,illu/ration3 ,reproduction 7r$uc$7 ( an adv]tisem5t ( ,hymosa4 ,?is indicates ! attempt made to convey1 by implication1 ! idea t ! salicylates are abs5t f ,hymosa4 ,exam9ation4--,hymosa z pur*as$ on ! m>ket is a d>k br[n liquid ) an odor ( sassafras & a r sweeti% ta/e1 react+ acid to litmus4 ,qualitative te/s hav+ indicat$ ! pres5ce ( salicylate1 iodid1 sodium1 potassium1 alcohol & "s organic matt]1 presumably sug>s & "s plant extractives1 ^! 7 det]m9$ quantitatively4#if ,x 0 f\nd t a "p ( ! salicylate 0 pres5t z free salicylic acid & "p 9 a comb9$ =m4 ,! sodium det]m9ations indicat$ t all ! salicylate1 except+ t 9 ! =m ( free salicylate acid1 0 pres5t z sodium salicylate4 ,f ! results ( ! potassium e/imations1 x 0 evid5t t ! iod9 0 pres5t 9 ! =m ( potassium iodid4 #if ,details ( ?is analysis appe> 9 ! annual report = #aiaj ( ! ,*emical ,laboratory ( ! ,am]ican ,m$ical ,association4 ,f ! results ( ! analysis x is believ$ t ! prep>ation has approximately ! foll[+ composition3 ,salicylic ,acid #j4cb gm4 ,sodium ,salicylate #a4ae gm4 ,potassium ,iodid #j4cb gm4 ,sug>s & extractives #d4fj gm4 ,alcohol1 ,u4 ,s4 ,p4 #af4hf c4c4 ,wat] to make #ajj4jj c4c4 ,^! results indicate t hymosa is ess5tially a solution conta9+ salicylic acid1 sodium salicylate1 potassium iodid1 alcohol1 sug>s & plant extractives 9 ! proportions giv5 above1 & %[ t ! v>i\s /atem5ts ref]r$ to1 reg>d+ ! abs5ce ( salicylic acid & salicylates are mislead+ & untrue4 ,x fur!r illu/rates ! repeat$ly demon/rat$ fact t no/rums exploit$ z wond]ful & new discov]ies are new 9 "n only--& :atev] !rapeutic value !y possess dep5ds on old & tri$ m$ic9al ag5ts4 ,editorial ,note3 ,9 describ+ ! me?ods employ$ by ! manufactur]s ( ,manola 9 exploit+ _! product1 att5tion 0 call$ to ! fact t ! ,manola ,company 0 report$ z be+ a subsidi>y affair ( ! ,luyties ,homeopa?ic ,ph>macy ,company ( ,/4 ,l\is4 ,x is report$ t ?is same company also op]ates ! ,walk] ,ph>macal ,company1 :i* exploits ,hymosa & ,psa-av5a4--7,f ! ,j\rnal ,a4 ,m4 ,a41 ,june #aa1 #aiaj47 ,,micajah',s ,,m$icat$ ,,ut]9e ,,waf]s ,w4 ,a4 ,puckn] & ,w4 ,s4 ,hilp]t ,evid5tly t\*$ by ! g5]osity ( ! manufactur] 9 s5d+ him a sample & lit]ature1 b n too favorably impress$ by ! claims made = ! prep>ation ref]r$ to1 a correspond5t writes3 ,i enclose a valuable sample & lit]ature j receiv$4 ,su* a palpable humbug z ,micajah's ,ut]9e ,waf]s w\ld h>dly seem to ne$ notice 7 x n probably true t _m practition]s habituat$ to ! use ( samples are /ill influ5c$ by ! gl[+ acc\nts ( cures wr\ght2 especially :5 atte/$ by su* a "n & title z 8,elmore ,palm]1 ,m4,d41 ,ex-,presid5t ,we/]n ,new ,york ,m$ical ,society40 ,?is secret gynecologic m$icam5t is recomm5d$ = any?+ f 8,pruritis ,vulv10 8,enl>gem5t ( ! ,womb10 8,displacem5ts10 8,cy/ocele & ,rectocele10 to ! 8,m5opause40 ,foll[+ ! def9ition t by h] 8/oma*0 a woman means any?+ f h] *9 to h] knees1 ! ex-presid5t ) truly noble imp>tiality has ) ! wond]ful ,micajah waf]s wr\ght lightn+ cures all ! way f 8/one-bruise0 ( ! heel to nasal polyp & influ5za1 & "s ( !m are male pati5ts too4 ,) ! =ego+ z an impetus to inve/igate ! nature ( ?is mu* adv]tis$ no/rum1 ! waf]s 7 submitt$ to analysis by ! ,association laboratory4 ,! report foll[s3 ,,laboratory ,,f9d+s ,trade packages ( ! waf]s pur*as$ on ! op5 m>ket be> ! "n ( ! prep>ation & t ( ! manufactur]s1 ,micajah ,co41 ,w>r51 ,pa4 ,! label /ates t ! no/rum is a3 8,dis9fectant1 a/r+5t & local alt]ative ( ! greate/ virtue4 ,a rem$y = ! local treatm5t ( ! diseases ( wom54 ,inflammation1 engorgem5t & prolapse ( ! womb1 vag9itis1 leucorrhea1 m5/rual d]angem5ts & ! di/urbances incid5tal to ! m5opause4 ,also highly recomm5d$ = affections ( ! muc\s membranes 9 g5]al1 p>ticul>ly ^? ( ! nose1 ! ?roat1 ! rectum1 & = gonorrhea1 cy/itis1 etc40 8,?is box conta9s waf]s = ?ree mon?s' treatm5t40 8,price p] box #a4jj40 ,! box conta9$ #be tablets1 & a circul> entitl$1 8,h9ts on ! treatm5t ( diseases ( wom510 9 :i* directions = ! treatm5t ( _m diseases are giv54 ,x ends ) a p>agraph :i* conta9s ! foll[+ /atem5t3 8,!re is no d\bt t ! field ( usefulness ( ,micajah's ,waf]s c be indef9itely enl>g$ by ! +5uity & !rapeutic skill ( ! physician40 ,mu* ( ! adv]tis+ 8lit]ature0 is 9 ! =m ( leaflets1 bro*ures & small pamphlets full ( te/imonials by physicians4 ,micajah's ut]9e waf]s z f\nd on ! m>ket are :ite1 hexagonal tablets1 odorless & possess+ an a/r+5t ta/e4 ,! waf]s are soluble 9 wat] ) extreme difficulty4 ,hot hydro*loric acid & alkali hydroxids dissolve ! p[d]$ tablets readily1 leav+ a slight residue :i* "u ! microscope & by physical te/s 0 id5tifi$ z lycopodium4 ,! acid solution ( ! waf]s respond$ to qualitative te/s :i* indicat$ ! pres5ce ( potassium1 sodium1 alum9um sulphate1 borate & a m]e trace ( a fatty mat]ial4 ,quantitative e/imation ( boric acid1 alum9um sulphate1 sodium & potassium 7 made1 :i* indicat$ t ,micajah's ,ut]9e ,waf]s consi/ ( alum m or less anhydr\s or 8burnt10 boric acid & borax 9 approximately ! foll[+ proportions3#ig #ig ,details ( ?is analysis appe> 9 ! annual report = #aiaj ( ! ,*emical ,laboratory ( ! ,am]ican ,m$ical ,association4 ,alum1 dri$ #ei4hf p] c5t4 ,borax1 dri$ #ae4fb p] c5t4 ,boric acid #e4fg p] c5t4 ,wat] ( hydration #ah4he p] c5t4 ,! av]age weight ( ! tablets is #j4ggia gm 7#aa4h gra9s7 & all[+ = ! fact t ! quantity ( wat] pres5t 9 comm]cial exsiccat$ alum v>ies1 ea* tablet w\ld conta9 approximately #j4dihf gm4 7#g4h gra9s7 burnt alum2 #j4bccg gm4 7#c4f gra9s7 cry/alliz$ borax1 & #j4jdfg gm4 7#j4g gra97 boric acid4 ,,comm5t ,judg+ f ! 8lit]ature0 t goes ) ! packages ( ?is no/rum1 "o might imag9e t x 0 put up absolutely = ! layman1 b ?is is n ! case4 ,x is adv]tis$ only 9 m$ical j\rnals & n directly to ! public4 ,b direct adv]tis+ to ! public is n necess>y2 = e physician :o prescribes ^! waf]s at ! same "t places 9 ! h&s ( 8 pati5t adv]tis+ matt] int5d$ to influ5ce t pati5t--& x usually does4 ,z a result ?is prep>ation is be+ b\ght by ! public direct4 ,to :at ext5t we d n "k1 b physicians are responsible = x4 ,probably if physicians realiz$ t ! same int]e/s t control ,piso's ,consumption ,cure also control ,micajah's ,m$icat$ ,ut]9e ,waf]s !y w\ld n be s ready to act z ! unpaid ag5ts = ! conc]n4 ,t su* simple a/r+5ts & feeble antiseptics z alum1 borax & boric acid c\ld h su* rem>kable curative effects on ut]9e diseases is absurd4 ,! s]i\s aspect ( ! matt] is1 t1 by ! enc\ragem5t giv5 !m 9 ! adv]tis+ lit]ature to treat !mselves1 wom5 may neglect prop] surgical or m$ical att5tion 9 ! e>ly /ages ( s]i\s diseases su* z canc] or dang]\s pelvic infections1 until !y get beyond ! hope ( prop] managem5t4 ,b :5 no/rum promot]s urge ! use ( su* ineffici5t rem$ies 9 ! treatm5t ( gonorrhea1 x is "t to look at ! matt] s]i\sly4 ,consid]+ ! vital social significance ( ! v5]eal diseases1 ! employm5t ( useless rem$ies c only favor ! spread ( ^! infections1 :i* cause su* a l>ge proportion ( ! diseases :i* afflict wom5 p>ticul>ly4 ,! m$ical pr(ession = ! mo/ "p has become m5tally call\s$ to ! exagg]at$ claims ( ! no/rum mak]s & does n make suffici5t ef=t to condemn !m4 ,!re may be "s physicians1 h[ev]1 :o use su* prep>ations z ^! waf]s 9 _! practice1 z is indicat$ by ! circul>s :]e9 ! manufactur]s sugge/ t _! 8usefulness c be indef9itely enl>g$ by ! +5uity & !rapeutic skill ( ! physician40 ,x is only occasionally t a physician voices 8 indignation z to ^! humbugs1 z 9 ! case ( ! physician ^: lett] is quot$ above4--7,f ! ,j\rnal ,a4 ,m4 ,a41 ,m>* #bf1 #aiaj47 ,! ,firm ,replies ,to ! ,editor3--,we h read ) int]e/ ! report ( y\r committee on ph>macology rec5tly publi%$ 9 ,! ,j\rnal1 on ! subject ( ,micajah's ,m$icat$ ,ut]9e ,waf]s1 & y\r comm5ts !reon4 ,we are ( ! op9ion t1 9 y\r laudable ef=ts to re=m ! practice ( ph>macology1 x is n y\r desire or int5tion to act o!r ?an ju/ly & fairly1 & !re=e1 ) ?is belief1 we submit ! foll[+ /atem5ts = y\r consid]ation1 ) ! hope t y w see fit to publi% !m4 #a4 ,we d n seek by ^w or de$ ! patronage ( ! laity1 & :at few sales are made to ! public are n ( our contriv+1 nor %\ld we be held responsible = !m1 any m ?an is ! manufactur] ( qu99 to be blam$ = ! univ]sal use ( t drug4 #b4 ,our lit]ature %\ld n be consid]$ extravagant1 = x is = ! mo/ "p made up ( cl9ical reports receiv$ f physicians & bas$ on ! unsolicit$ te/imonials 9 our possession f hundr$s ( practition]s1 _m ( :om h us$ ,micajah's ,waf]s 9 practice f five to tw5ty ye>s & !y are !re=e z well gr\nd$ z are ! cl9ical reports conc]n+ any prep>ation4 #c4 ,9 ! pa/ ye> we h endeavor$ to place our prep>ation on a high] e?ical basis by /at+ 9 our adv]tisem5ts :at our waf]s conta91 & by elim9at+ :atev] seems to u op5 to criticism4 #d4 ,t ! +r$i5ts ( ! prep>ation are 8simple0 is no reason = consid]+ !m valueless4 ,h4 ,a4 ,kelly1 9 8 "w on m$ical gynecology1 page #bff1 recomm5ds ^! +r$i5ts 9 a v>iety ( conditions4 ,b&l] also made important recomm5dations be>+ on ?is subject 9 8 8,m$ical ,gynecology10 #aiji edition1 page #dgb4 ,we feel we h ! "r to recomm5d ?is prep>ation = ^! & simil> conditions1 especially :5 our /atem5ts are back$ up by ! cl9ical exp]i5ce ( num]\s g5]al practition]s4 #e4 ,t ! own] ( ,micajah's ,waf]s holds /ock 9 a corporate firm :i* manufactures propriet>y m$ic9es & toilet articles1 adv]tis$ to ! laity1 %\ld n militate = or aga9/ our "r to m>ket a m]itori\s prep>ation on /rictly e?ical l9es to ! m$ical pr(ession1 inasmu* z _m ( ! l>ge/ drug h\ses cat] to bo? ! doctor & ! propriet>y int]e/s1 & sev]al are actively engag$ 9 exploit+ s-call$ no/rums4 #f4 ,we enclose a rec5t adv]tisem5t :i* has be5 accept$ aft] inve/igation ( our me?ods by c>eful m$ical j\rnals1 & we n[ believe we are conduct+ our bus9ess 9 entire con=mity ) ! be/ int]e/s ( ! m$ical pr(ession & we feel c]ta9 ( ! true m]its ( our article4 ,micajah ,company1 ,w>r51 ,pa4 ,comm5t3 ,?is lett] br+s out /ill m /rongly ! po9ts rais$ 9 ! article :i* appe>$ 9 ,! ,j\rnal1 ,m>* #bf1 #aiaj4 ,be+ unable to analyze motives we mu/ p]=ce1 accept ,micajah ,co4's /atem5t t !y 8d n seek by ^w or de$ ! patronage ( ! laity40 ,9 ! comm5ts on ! laboratory's report x 0 v explicitly /at$ t ?is no/rum 0 adv]tis$ only 9 m$ical j\rnals & n directly to ! public4 ,inasmu*1 h[ev]1 z ! conta9] 9 :i* ?is product comes has pr9t$ on x ! v>i\s diseases 9 :i* ! 8waf]s0 are indicat$1 z1 moreov]1 )9 ! conta9] !re is a leaflet :i* describes 9 detail ! use ( ! prep>ation 9 a li/ ( pa?ologic /ates v>y+ f 8enl>gem5t ( ! womb0 to 8gonorrhea 9 ! male10 &1 f9ally1 z ! "n 8ut]9e waf]s0 w\ld seem 9 itself to be a pla9 bid to ! public1 we /ill ma9ta9 t 8"o might imag9e t is 0 put up absolutely = ! layman40 ,! proposition t adv]tis+ matt] %\ld n be consid]$ extravagant because x is l>gely 8made up ( cl9ical reports receiv$ f physicians0 is an argum5t t is z old z ! no/rum bus9ess itself--& z fallaci\s z x is old4 ,un=tunately1 z our files %[1 ! mo/ extravagant /atem5ts made = propriet>y products frequ5tly emanate f m5 :o legally are entitl$ to write ,m4,d4 aft] _! "n4 ,! fact t x is n ! manufactur] b a ,buffalo physician :o tells ( ! m>vel\s results he obta9$ f ! use ( ,micajah's ,m$icat$ ,ut]9e ,waf]s 9 =ty-?ree cases compris+ no few] ?an ?irty-six pa?ologic conditions f 8otitis m$ia0 to 8injur$ toe10 & f 8bunion0 to 8oph?almia neonatorum0 does n exempt ! firm t pr9ts su* /uff f ! *>ge t its 8lit]ature0 is n m]ely extravagant1 b ridicul\sly s4 ,z ,micajah ,co4 say1 because ! +r$i5ts ( _! prep>ation are simple is no reason = consid]+ !m valueless4 ,on ! contr>y1 if ! 8waf]s0 7 tru?fully exploit$ = :at !y are & :at !y w d1 _! v simplicity w\ld be a virtue4 ,b su* has n be5 done4 ,& !re9 lies ! vici\sness ( no/rums4 ,simple mixtures ( well-kn[n drugs are foi/$ on ! m$ical pr(ession ) no h9t z to _! composition & ) claims made t are n only false1 b w\ld imm$iately be recogniz$ z absurd1 if _! actual composition 7 kn[n4 ,t a mixture ( borax & alum may be ( value 9 "s ( ! simple ailm5ts ( ! female g5ital tract c easily be grant$4 ,t relief might foll[ ! use ( suppositories made ( ^! +r$i5ts--especially :5 supplem5t$ by an increas$ att5tion to simple cleanl9ess--c also be admitt$4 ,to say1 h[ev]1 t su* m$icam5ts w quickly & p]man5tly cure gonorrhea1 ure?ritis1 endometritis1 etc41 is fooli%1 false & vici\s4--7,f ! ,j\rnal ,a4 ,m4 ,a41 ,april #af1 #aiaj47 ,,noitol ,,& ,,anadol ,w4 ,a4 ,puckn] & ,l4 ,e4 ,w>r5 ,noitol ,! ,j\rnal receiv$ an inquiry conc]n+ ! composition ( ,noitol1 a prep>ation :i* is be+ adv]tis$ to ! m$ical pr(ession z a 8specific0 = ! cure ( eczema & c]ta9 o!r cutane\s diseases4 ,! prep>ation is manufactur$ by ! ,:eel] ,*emical ,works1 ,*icago4 ,trade packages ( ,noitol 7 pur*as$ & exam9$ 9 ! ,association laboratory4 ,on ! label ( ! package1 ,noitol--an inv]sion ( ! ^w 8lotion0--is describ$ z foll[s3 ---------------------------------------- ---------------------- ,,noitol 7,dr4 ,bradbury's ,eczema ,lotion47 ,= ,ext]nal ,application ,only6 ,our ,mo/ ,popul> ,specialty4 ,a specific = ! cure ( ,eczema1 ,scr(ul\s & ,syphilitic ,eruptions1 ,lupus1 ,salt ,rheum1 ,tett]1 ,it*4 ,?is rem$y is compos$ ( valuable ,oils1 comb9$ ) ,vegetable & ,m9]al ,acids 9 su* proportions z cause a rapid & p]man5t cure ( ! above compla9ts4 ---------------------------------------- ---------------------- ,noitol is a cle>1 ne>ly colorless1 acid solution1 ! great] portion ( :i* is wat]4 ,its specific gravity is #a4jjig at #be ,c4 ,qualitative te/s demon/rat$ ! pres5ce ( a *lorid1 a nitrate1 a m]curic salt1 free acid & glyc]94 ,no 8oils0 or 8vegetable acids0 c\ld be f\nd4 ,analysis#ih ( ! prep>ation indicat$ t its composition is ess5tially z foll[s3 #ih ,details ( ?is analysis are publi%$ 9 ! annual report = #aiaj ( ! ,*emical ,laboratory ( ! ,am]ican ,m$ical ,association4 ,m]curic ,*lorid #j4jdfc gm4 9 #ajj c4c4 ,m]curic ,nitrate #j4jdej gm4 9 #ajj c4c4 ,glyc]9 #a4cjba gm4 9 #ajj c4c4 ,nitric ,acid #a4jbfe gm4 9 #ajj c4c4 ,wat] 7by diff]5ce7 #ih4eede gm4 9 #ajj c4c4 ,f ! above x appe>s t ,noitol is simply a weak1 acid solution ( m]cury salts--! total be+ approximately equival5t to a #a to #a1jjj bi*lorid ( m]cury solution--exploit$ "u a mean+less "n4 ,x is b "o m example ( ! old1 old /ory ( a well-kn[n rem$y be+ sold at a high price "u a "n :i* is 9 no way indicative ( its composition1 & "u claims :i* are absurdly false4 ,! price ( ! mixture is #b4jj a p9t2 ! e/imat$ co/1 exclusive ( ! conta9]1 is ab\t #f c5ts a gallon1 or1 put ano!r way3 ! price ( a p9t bottle1 x is e/imat$1 w\ld make a b>rel 7#ca gallons7 ( ! no/rum4 ,! incorrect /atem5t conc]n+ its compon5ts1 ! unw>rant$ !rapeutic claims made = x1 & ! exorbitant price easily place ,noitol 9 ! front rank among ! 8pat5t m$ic9e0 frauds4 ,yet x is adv]tis$ to physicians z an e?ical propriet>y & is evid5tly be+ prescrib$ by !m4 ,anadol ,9 ! circul> matt] accompany+ ! trade package ( ! prep>ation1 8,noitol10 describ$ above1 a prep>ation call$ 8,anadol0 is describ$4 ,anadol is claim$ to be an analgesic & antipyretic4 ,9 ! descriptive circul> !re is no in=mation conc]n+ ! composition ( ! prep>ation1 b f ! g5]al !rapeutic description ! physician might easily be l$ to believe t 8,anadol0 is a di/9ct *emical sub/ance4 ,to r$uce temp]ature ! physician is advis$ to pu% ! adm9i/ration ( ,anadol 9 #aj gra9 doses until ! febrile condition is "u control or until a maximum ( #gj gra9s ( ! prep>ation has be5 +e/$4 ,! circul> fur!r /ates3 8444 9 ?is lies ! special value ( ,,anadol2 !re are no annoy+ by-effects2 ! /oma* be>s ! rem$y well & nei!r circulation1 respiration1 nor ! n]ve c5t]s %[ ! lea/ di/urbance40 ,z no evid5ce c\ld be obta9$ conc]n+ ! composition ( ,anadol &1 z ! prep>ation is be+ br\ght to ! att5tion ( physicians by means ( circul>s 9 connection ) ! di/ribution ( ,noitol1 x seem$ wor? :ile to take up its exam9ation 9 ! ,association laboratory4 ,accord+ly a trade package ( ! mat]ial :i* _h pass$ into int]/ate comm]ce 0 pur*as$4 ,qualitative te/s demon/rat$ ! pres5ce ( sodium1 a c>bonate1 caffe9 & acetanilid1 ! latt] 9 consid]able quantities4 ,analysis#ii indicat$ t ! composition ( ! specim5 exam9$ is ess5tially z foll[s3 ,acetanilid #gi p] c5t4 ,caffe9 #a p] c5t4 ,sodium bic>bonate #bj p] c5t4 #ii ,details ( ?is analysis are publi%$ 9 ! annual report = #aiaj ( ! ,*emical ,laboratory ( ! ,am]ican ,m$ical ,association4 ,s9ce1 accord+ to ! circul>1 x is p]missible to prescribe #gj gra9s ( ?is prep>ation )9 #b-a_/b h\rs1 a pati5t ?us treat$ w\ld receive no less ?an #ee gra9s ( acetanilid6 ,9 view ( ! num]\s cases ( poison+ due to ! misuse ( acetanilid 78,! ,h>mful ,effects ( ,acetanilid1 ,antipyr9 & ,ph5acet910 ,u4 ,s4 ,dept4 ,agric41 ,bur4 ,*em41 ,bull4 ,no4 #abf7 ! physician %\ld be appris$ ( ! composition ( ,anadol4 ,editorial ,note3 ,! *emical inve/igations report$ above emphasize once m ! ne$ ( su* an in/itution z ! ,association's laboratory & aga9 demon/rates ! value ( its "w4 ,at fir/ sight x seems di%e>t5+ to f9d t physicians are s easily humbugg$4 ,yet :5 x is rememb]$ t x is impracticable = physicians ei!r to analyze su* products !mselves or to g to ! exp5se ( hav+ *emi/s d x = !m1 x is evid5t t ! fault lies n s mu* ) ! physicians z ) ! conditions t make ! exploitation ( su* frauds possible4 ,x is on ! public t ! burd5 ultimately falls1 = x is ! layman :o has to pay two doll>s = a few c5ts' wor? ( m$ic9e4 ,b--& ?is is f> m s]i\s--t ! physician %\ld be urg$ to dose 8 pati5t ) an insidi\sly dang]\s drug to a po9t f> beyond ! limits ( safety1 is little less ?an crim9al4 ,yet s long z unkn[n m$ic9al products are prescrib$ j s long w ?is dang] be a v real "o4--7,f ! ,j\rnal ,a4 ,m4 ,a41 ,may #ba1 #aiaj47 ,anadol ,decl>$ ,misbr&$ ,anadol 0 analyz$ at ! ,bureau ( ,*emi/ry & ! *emi/s report$ t x conta9$ ov] #hb p] c5t4 ( ,acetanilid4 ,z ! labels did n be> any /atem5t z to ! quantity ( acetanilid conta9$ 9 ! no/rum1 ! /uff 0 decl>$ misbr&$ & ! def5dant1 on plead+ guilty1 0 f9$4--,notice ( ,judgm5t ,no4 #gie4 ,,pix ,,cresol ,w4 ,a4 ,puckn] & ,w4 ,s4 ,hilp]t ,9 a pap] on 8,! ,abuse ( ,*emical ,=mulas0#ajj sev]al examples 7 giv5 ( ! v>i\s me?ods employ$ by 8pat5t-m$ic9e0 conc]ns to give /&+ to _! products by assign+ to !m a *emical =mula4 ,9 "s cases ! =mulas giv5 are impossible1 9 o!r cases !y may repres5t ! *emical composition ( only "o con/itu5t or x may be an attempt at bo?4 ,to a *emi/ su* =mulas are absurd & on see+ a =mula :i* he kn[s to be wrong he naturally ?9ks 8,fake10 8,ignorance10 or bo?4 ,j su* a =mula 7,c#e;,h#f,n4,,s7 appli$ to a product call$ ,pix ,cresol1 manufactur$ by ! ,pix ,cresol ,*emical ,co41 ,kansas ,city1 ,mo41 attract$ our att5tion4 ,no m5tion ( su* a =mula c be f\nd 9 su* works z ,ri*t]'s mo/ complete ,index ( ,c>bon ,comp\nds1 nor ! ?ree supplem5tal volumes publi%$1 #aija-aije1 by ! ,g]man ,*emical ,society & ,beil/e9's ,organic ,*emi/ry 7#c;d ,ed474 ,?is fact1 supplem5t$ by inquiries f correspond5ts z to ! composition ( ! sub/ance made x seem wor? :ile to make a *emical exam9ation ( x4 #ajj ,puckn]1 ,w4 ,a43 ,report ( ! ,*emical ,laboratory ( ! ,am]ican ,m$ical ,association1 iii1 #g4 ,! exam9ation 0 made & %[$ t ! ess5tial con/itu5t 0 oxyqu9ol9 sulphate4 ,z potassium sulphate 0 also f\nd x 0 conclud$ t ,pix ,cresol 0 a prep>ation conta9+ a mixture ( oxyqu9ol9 sulphate & potassium sulphate1 :i* has also be5 kn[n 9 ! pa/ "u ! propriet>y "n1 8,*9osol40 ,at ?is "t a lett] 0 ref]r$ to ! laboratory conta9+ ! report ( an analysis ( ,pix ,cresol1 :i* %[$ ! pres5ce ( oxyqu9ol9 sulphate b no potassium sulphate4 ,z ?is indicat$ t ,pix ,cresol conta9$ z its ess5tial con/itu5t ! sub/ance n[ sold z ,*9osol1 ! laboratory pur*as$ a new specim5 ( ,pix ,cresol f ! ,*icago repres5tative ( ! ,pix ,cresol ,co4 ,! exam9ation#aja ( ?is specim5 %[$ t x consi/$ ( approximately #ba p] c5t4 oxyqu9ol9 sulphate1 ab\t #h4c p] c5t4 potassium sulphate & ! rema9d] almo/ entirely milk sug>4 #aja ,! analytical details w be publi%$ 9 ! annual report ( ! laboratory4 ,x is evid5t1 !n1 t bo? ! specim5 ( ,pix ,cresol obta9$ directly f ! manufactur]s & also ! "o pur*as$ m rec5tly f ! ,*icago ag5t1 conta9 z an ess5tial con/itu5t ,*9osol ( ! composition sold =m]ly4 ,! sub/ance n[ sold "u ! "n ,*9osol & describ$ 9 ,new & ,non(ficial ,rem$ies is pure oxyqu9ol9 sulphate1 & z ! exploit]s ( ,pix ,cresol probably obta9 _! supply ( oxyqu9ol9 sulphate f ! ,*9osol ,company1 ! sole ,am]ican ag5ts = ,*9osol1 x is to be expect$ t ,pix ,cresol %\ld *ange 9 composition4 ,x is probable t ! analysis ref]r$ to ! laboratory deals ) a m rec5t specim5 ?an ! two exam9$ 9 ! ,association laboratory4 ,editorial ,note3 ,9 view ( ! ,c\ncil on ,ph>macy & ,*emi/ry's f9d+s1 viz41 t *9osol is a p[]ful antiseptic b a feeble g]micide & consid]+ t ,pix ,cresol conta9s b #ba p] c5t4 oxyqu9ol9 sulphate1 ! absurdity ( ! foll[+ claims made = ,pix ,cresol require no fur!r comm5t3 8,pix ,cresol is an ,absolutely ,sure & ,yet ,p]fectly ,safe1 ,nev] ,fail+ ,de/roy] ( ,pus 7,/aph4 ,pyog5es ,aureus470 8,x is g]micidal1 bact]icidal1 bacillicidal4 ,x is c]ta9 z a micro-organism de/roy]4 ,x de/roys absolutely40 8,ridd+ ! blood ( g]ms1 x aids 9 r5d]+ x replete ) oxyg5----40 8,x kills ! g]ms40 8,no organism t is causative ( morbid processes c )/& x40 8,x de/roys micro-organisms ( all k9ds4 ,x de/roys !m absolutely40 8,! g]m's t5acity ( life does n avail aga9/ its action z g]micide40 8,x de/roys ! spores & tox9s utt]ly40 ,a fur!r e/imate ( ! pseudo-*emical company1 be>+ ! "n ( ?is 8/ronge/1 safe/1 lea/ exp5sive m$ical antiseptic1 dis9fectant & deodoriz] kn[n0 may be ga9$ by a cursory glance at "s ( its 8specialties03 8,maiz99 comp\nd1 ,positive ,*ill & ,mal>ia ,specific0 ! firm says1 8prep>es ! p>asites = execution by ! leukocytes40 ,x is said to conta9 ars5ic1 :ile ! "n implies ! pres5ce ( "s plant drug4 8,psora1 ! ,syphilis ,specific10 is a %ot-gun mixture said to be 8! sci5tific comb9ation ( ! soluble ,triple ,iodids ) ! active pr9ciples ( ,e*9acea1 ,casc>a amagra1 ,b]b]is aquif41 & ,phytolacca rad410 & is claim$ to make 8! syphilitic lesions disappe> & fail to return40 8,rectoids--,cones = ! treatm5t ( all rectal tr\ble10 are said to be 8a comb9ation ( ,rect9 7,pix7 comp\nd$ f ,buckeye1 ,coll9sonia1 ,hamamelis1 ,belladonna1 ,pix ,cresol40 8,tablets = ! ,female--,pix ,cresol ,ut]ettes10 x is said1 8= sanit>y purposes may be cont9u$ =ev] 4440 ,:5 "o realizes t ?is sort ( pseudo-sci5tific twaddle is accept$ by _m physicians at its face value1 ! outlook = !rapeutics seems d>k1 inde$4 ,s long z ! exi/5ce ( su* conc]ns is tol]at$ by ! m$ical pr(ession1 s long w !re be a cry+ ne$ = a 8,propag&a = ,re=m 9 ,propriet>y ,m$ic9es40--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,june #aj1 #aiaa47 ,,saliod9 ,w4 ,a4 ,puckn] & ,a4 ,h4 ,cl>k ,! ,c\ncil on ,ph>macy & ,*emi/ry refus$ recognition to ,saliod9 because x conflicts ) ,rules #a & #f1 & direct$ publication ( ! foll[+4 ,w4 ,a4 ,puckn]1 ,secret>y4 ,saliod9 is sold by ! ,saliod9 ,*emical ,co41 ,scranton1 ,pa4 ,9 ! lit]ature & on ! trade package ! foll[+ 8=mula0 is giv53 ---------------------------------------- ------------------ ,,=mula ,ea* ,grs4 ,,xx ( ,saliod9 conta9s approximately3 ,salicylic ,acid1 7,aceto-,salicylate7 ,grs4 ,,xv ,iod9e1 7,iodate7 ,equival5t to ,iodide ,potass ,grs4 ,,xv ,acetic ,acid1 7,acetate7 ,equiv4 to ,acetate ,potass ,grs4 ,v ,aconite ,equiv4 to 88 ,tr4 ,aconite ,r4 ,gtts4 ,,iv ,bryonia 88 ,tr4 ,bryonia1 ,gtts4 ,v ,col*icum ,v9 ,col*icum ,r4 ,gtts4 ,,xv ,capsicum ,tr4 ,capsicum ,gtts4 ,,ii ,oil ,gaul!ria ,,iii ---------------------------------------- ------------------ ,?is =mula be+ indef9ite & vague1 ! exam9ation ( saliod9 0 tak5 up 9 ! ,association laboratory4 ,f ! analysis we calculate ! composition ( saliod9 to be approximately equival5t to a mixture (3 ,sodium salicylate #eg4ed ,potassium iodid #a4ah ,potassium acetate #cj4jj ,matt] volatile at #acj 7oil ( anise1 oil ( gaul!ria1 moi/ure1 etc47 #h4aj ,undet]m9$ 7extractive87 #c4ah ------ #ajj4jj ,! analysis %[s t ! =mula is n only indef9ite & vague1 b incorrect & false4 ,to emphasize ! incorrectness ( ! publi%$ =mula ! foll[+ comm5t on its fir/ two items is (f]$3 ,9 ! 8=mula0 x is /at$ t #bj gra9s ( saliod9 conta9 approximately 8salicylic acid 7aceto-salicylate7 ,grs4 ,,xv40 ,! /atem5t is n cle>1 b conveys ! impression t #bj gra9s ( saliod9 conta9 an am\nt ( aceto-salicylate1 a salt ( acetyl-salicylic acid 7aspir971 equival5t to #ae gra9s ( salicylic acid4 ,b ! *emical exam9ation %[s t x conta9s nei!r acetyl-salicylic acid1 nor salt ( acetyl-salicylic acid1 nor ev5 salicylic acid itself4 ,9 ! place ( ^!1 ! analysis %[s t ov] half ( saliod9 is ! common1 e-day sodium salicylate4 ,illu/ration3 ---------------------------------------- ----------------------- ,x is an 8,iodat$1 ,aceto-,salicylate ) ,adjuvants10 & ! ,,specific treatm5t = e =m ( ,,uric ,,acid ,,dia!sis4 8,saliod90 is a ,,solv5t & ,,elim9ant ( ,,uric ,,acid & is a happy comb9ation ( ,salicylic ,acid1 ,iod9e1 ,acetic ,acid1 ,aconite1 ,bryonia1 ,col*icum1 ,capsicum & ,gaul!ria & *emically appe>s 9 ! =m ( a ,,p9k1 ,,greyi% ,,p[d] soluable 9 wat] #a to #c--;dose grs4 ,x to grs4 ,,xxx2 = ! ,,exclusive ,,use ,,( ,,physicians--put up 9 "o ounce bottles2 price ,,p] ,,ounce #a4ej4 ,is manufactur$ ,,only by ! ,saliod9 ,*emical ,co4 8,,saliod9 is ,,specifically indicat$ 9 ,,rheumatism1 ,,g\t ,,neuralgia1 ,,mal>ia & ,,la ,,grippe2 is ,,analgesic1 ,,antipyretic2 an ,,inte/9al ,,antiseptic1 ,,diaphoretic1 ,,diuretic1 ,,expectorant1 ,,deob/ru5t1 ,,sialagogue1 ,,*olagogue1 ,,emm5agogue1 ,,anti-,,syphilitic1 ,,gonocococidal1 ,,p>asiticidal1 ,,aseptic1 ,,bact]icidal & ,,alt]ative4 ,doctor1 y may prescribe ,saliod9 ) confid5ce :]ev] ,,iod9e or a ,,salicylate is indicat$4 ,us$ bo? int]nally & ext]nally4 ---------------------------------------- ----------------------- ,reproduction 7mu* r$uc$7 ( a p>agraph 9 ! adv]tis+ pamphlet on ,saliod94 ,note ! tw5ty-"o indications = ,saliod94 ,le/ "s condition might be ov]look$1 we are advis$ to use x 8int]nally & ext]nally40 ,isn't ?is sci5tific !rapy8 ,accord+ to ! 8=mula10 ea* #bj gra9s ( saliod9 conta9s 8iod9 7iodate71 equival5t to iodid potass4 ,grs4 ,,xv40 ,?is /atem5t1 too1 is vague1 b conveys ! impression t #bj gra9s ( saliod9 conta9 an am\nt ( iod91 9 comb9ation z an iodate1 :i* corresponds 9 iod9 cont5t to #ae gra9s ( potassium iodid4 ,b ! analysis %[s t ! product does n conta9 any iodate :atev]1 & t ! am\nt ( iod9 conta9$ 9 x is suffici5t to acc\nt = only #a_/d gra9 ( potassium iodid 9 ea* #bj gra9s ( saliod94 ,,comm5ts ,! above report is publi%$ simply z ano!r example ( ! 8e?ical propriet>ies0 t physicians are ask$ to prescribe4 ,x is n unique4 ,x is nei!r bett] nor worse ?an hundr$s ( o!rs4 ,to %[ :at absurdities appe> 9 ! 8lit]ature0 787 t is s5t to physicians1 we reproduce a p>agraph f an adv]tis+ pamphlet4 ,! promot]s' /atem5t z to ! composition ( ! product is absurd1 b n m s ?an are ! claims made = x z a !rapeutic ag5t4 ,!re is n a 8pat5t m$ic9e0 on ! m>ket = :i* any m blatant1 extravagant & ridicul\s claims are made4 ,! mann] ( exploit+ saliod9 is ano!r illu/ration ( ! t5d5cy on ! "p ( no/rum-mak]s to adv]tise _! w>es ?r\gh pseudo-sci5tific articles publi%$ 9 a c]ta9 class ( m$ical j\rnals4 ,9 ! pamphlet s5t out by ! ,saliod9 ,company appe>s a repr9t ( an article f ! ,philadelphia ,m$ical ,summ>y ( ,febru>y1 #aije4 ,x is entitl$ 8,a ,simil>ity 9 ! ,etiologic ,factors ( ,rheumatism & ,mal>ia10 & 0 writt5 by ,j4 ,c4 ,d5/on1 ,m4,d4 ,9 x occurs ?is /atem5t3 8,! manufactur]s 7( saliod97 publi% _! =mula &1 ,i ?9k1 di/ribute samples & lit]ature on reque/40 ,! *>m+ +5u\sness ( ?is /atem5t is fully realiz$ :5 x is und]/ood t ,j4 ,c4 ,d5/on is ! presid5t ( ! ,saliod9 company4 ,?is is also ano!r illu/ration ( :at is n[ a common occurr5ce1 viz43 m5 :o are engag$ 9 manufactur+ propriet>y products & :o h an ,m4,d4 degree use t degree z a comm]cial asset1 & by ?is means ! av]age read] is l$ to ?9k t articles writt5 by !m 9 praise ( _! own products are spontane\s tributes f practic+ physicians4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,oct4 #bf1 #aijg47 ,,!obrom9 ,,sodium ,,salicylate ,,v]sus 8,,diuret903 ,,! ,,economical ,,aspect ,w4 ,a4 ,puckn] & ,paul ,n4 ,lee* ,! foll[+ inquiry is f ,dr4 ,reid ,hunt1 rec5tly appo9t$ pr(essor ( ph>macology at ,h>v>d ,m$ical ,s*ool3 8,h y ev] made an exam9ation ( ! !obrom9 sodium salicylates on ! m>ket to det]m9e if !y are id5tical ) #8,diuret98' ,! description ( !obrom9 sodium salicylate 9 ,new & ,non(ficial ,rem$ies agrees ) ! /atem5ts z to ! composition ( ,diuret91 b ,i wond]$ if1 at times at lea/1 ! !obrom9 sodium salicylate on ! m>ket might be a simple mixture ( !obrom9 & sodium salicylate j z ! ,caffe9ae ,sodio-,salicylas1 ,n4 ,f41 seems to be a simple mixture4 ,diuret9 is quot$ 9 curr5t price-li/s at #a4ge an ounce1 :]eas ! price ( !obrom9 sodium salicylate is only #ce c5ts an ounce4 ,_m hospitals use diuret91 & bo? physicians & /ud5ts (t5 h only hazy ideas z to :at x is4 ,if ! prep>ations ( !obrom9 sodium salicylate n[ on ! m>ket are id5tical ) ,diuret9 !y %\ld c]ta9ly be us$1 n only because !y are less exp5sive1 b because ! descriptive "n w cont9ually rem9d ! physicians ( :at !y are us+40 ,!obrom9 = "s "t has be5 reg>d$ z a valuable !rapeutic ag5t4 ,! ob/acle to its use has be5 its insolubility & ! consequ5t unc]ta9ty ( ! degree ( its absorption4 ,= ?is reason a soluble salt ( !obrom91 !obrom9 sodium salicylate1 fir/ introduc$ & adv]tis$ "u ! propriet>y "n 8,diuret910 has come to be us$ to a consid]able ext5t4 ,!obrom9 sodium salicylate--also call$ !obrom9 & sodium salicylate--is prep>$ by int]action1 9 molecul> proportions1 ( !obrom91 sodium hydroxid & sodium salicylate1 ! !obrom9 fir/ be+ treat$ ) sodium hydroxid 9 ! pres5ce ( a suitable solv5t1 !n ! sodium salicylate add$ & ! :ole br\ght to dryness4 ,! soluble comp\nd :i* is =m$ is g5]ally consid]$ to be a d\ble salt ( !obrom9 sodium & sodium salicylate4 ,!obrom9 sodium salicylate is describ$ 9 ,new & ,non(ficial ,rem$ies & 9 sev]al =eign ph>macopeias4 ,x is also to be describ$ 9 ! =?com+ ,unit$ ,/ates ,ph>macopeia4 ,al?\gh ! product is n controll$ by pat5ts ( any k9d1 & al?\gh x is (f]$ = sale "u its *emical "n by ! lead+ *emical manufactur]s at f #ce to #de c5ts p] ounce1 ! propriet>y product1 ,diuret91 sells = #a4ge an ounce4 ,?is is probably because ! manufactur]s ?9k t ^? :o h be5 us+ x "u its *emically non-descriptive b !rapeutically sugge/ive title1 ,diuret91 w rema9 ignorant ( ! fact t ! same product is on ! m>ket "u its *emical "n4 ,9 view ( ^! conditions1 emphasiz$ by ,dr4 ,hunt's lett]1 x 0 deem$ important to exam9e ! m>ket-supply ( !obrom9 sodium salicylate & to comp>e ! sev]al specim5s ) ! propriet>y br& ,diuret94 ,! foll[+ specim5s1 pur*as$ 9 #a-ounce orig9al packages1 7 exam9$3 ,diuret91 8,knoll10 ,knoll ,co4 ,!obrom9e & ,sodium ,salicylate1 ,mall9ckrodt ,*emical ,works4 ,!obrom9e & ,sodium ,salicylate1 ,m]ck ,co4 ,!obrom9e & ,sodium ,salicylate ,p[d]1 ,p[]s-,weightman-,ros5g>t5 ,co4 ,!obrom9e & ,sodium ,salicylate1 8,ro*e10 ,h(fmann-,la ,ro*e ,*emical ,works4 ,!obrom9e & ,sodium ,salicylate1 ,squibb1 ,e4 ,r4 ,squibb ,sons4 ,! !obrom9 cont5t prescrib$ = !obrom9 sodium salicylate by ! v>i\s /&>ds ranges f #de to #ej p] c5t41 t ( ,new & ,non(ficial ,rem$ies be+ ! highe/4 ,a requirem5t ( n less ?an #df4e p] c5t4 !obrom9 9 ! dri$ p[d] has be5 propos$ = ! new ,u4 ,s4 ,ph>macopeia4 ,! me?ods ( quantitative e/imation laid d[n by ! v>i\s au?orities are all v simil> & consi/1 9 ! ma91 ( a det]m9ation ( wat]1 ( ! sodium hydroxid1 free & 9 comb9ation ) !obrom91 & ( ! !obrom9 itself4 ,= ! !obrom9 e/imation ! foll[+ me?od 0 employ$3 ,a weigh$ sample 7ab\t #b gm7 :i* _h previ\sly be5 dri$1 "u slightly r$uc$ pressure1 ov] sulphuric acid1 to con/ant weight1 0 dissolv$ 9 five times its weight ( w>m wat]4 ,two drops ( ph5olph?ale9 7 add$1 & ! solution titrat$ ) normal hydro*loric acid4 ,to ! neutral solution1 #a drop ( #aj p] c5t4 ammonium hydroxid solution 0 add$1 & ! mixture all[$ to /&1 ) occasional /irr+1 = ?ree & "o-half h\rs at ! temp]ature ( #ae ,c4 ,! precipitate 0 filt]$ on a weigh$ ,goo* crucible1 wa%$ ) j t5 times ! weight 7( ! orig9al sample tak57 ( wat] 7temp]ature #ae ,c47 & ! precipitate dri$ at f #ajj to #ajd4 ,to ! weight obta9$1 a correction factor 7prov$ satisfactory by quantitative extraction exp]im5ts on ! filtrate7 ( #j4ac gm4 0 add$1 = e #b grams ( ! orig9al sample tak54 ,! full details ( ! exam9ation w be publi%$ 9 ! #aiad ,reports ( ! ,a4 ,m4 ,a4 ,*emical ,laboratory4 ,! results ( ! exam9ation h be5 ab/ract$ & are compil$ 9 ! accompany+ table3 ,,summ>y ,,( ,,analysis ,gm4 9 ,price,mois-,alkal94,!o- ,!o- ,physical #a-,ouncep] ture1z ,na,o,h brom94 brom94 ,appe>ance,bottle ,ounce,p] on ,dry 9 ,dry 9 ,orig4 ,,aq ,c5t4,p[d] ,p[d] ,specim5 ,,ar ,p],,ar ,p],,ar ,p] ,c5t4 ,c5t4 ,c5t4 ---------------------------------------- ----------------------- ,diuret9 #c #bh4e #a4ge #j4ja #aj4dd #dh4fa #dh4fa ,pure ,:ite ,!o4 #c ,sod4 ,sal4 ,pure ,:ite #bg4e #j4ce #a4hi #i4ie #df4aa #de4bd ,m4 ,c4 ,w ,!o4 #a ,sod4 ,sal4 ,pure ,:ite #bi4j #j4ce #j4dh #aj4ch #dg4hg #dg4eh ,m]ck ,!o4 #c ,sod4 ,sal4 ,pure ,:ite #bi4a #j4ce #b4df #aj4cj #dg4eg #df4ci ,p4 ,w4 ,r4 ,co4 ,!o4 #c ,sod4 ,sal4 ,p9k #bh4f #j4ce #b4bg #i4ib #di4je #dg4ib ,ro*e ,!o4 #a ,sod4 ,sal4 ,pure ,:ite #bf4h #j4de #j4ci #i4ig #df4hb #df4fc ,squibb ---------------------------------------- ----------------------- ,,aq ,9 ?is column1 #a1 #b & #c d5ote ! foll[+3 #a4 ,q cry/all9e1 "u microscope4 #b4 ,fairly cry/all9e1 "u microscope4 #c4 ,n cry/all9e1 "u microscope4 ,,ar ,av]age ( det]m9ations4 ,:ile ! results %[ "s v>iation 9 ! moi/ure cont5t & also 9 ! actual !obrom9 cont5t ( ! dri$ specim5s1 ! v>iation is unimportant4 ,! products 9 _! orig9al /ate 7undri$71 z comp>$ 9 relation to ! !obrom9 cont5t 7! highe/ p]c5tage ( !obrom9 be+ #dh4fa1 ! l[e/ #de4bd71 reveal a v>iation ( only ab\t #c p] c5t4--a v>iation :i* is negligible 9 ! case ( drugs su* z !obrom94 ,f ! prec$+ inve/igation1 x is conclud$ t 7#a7 practically !re is no diff]5ce betwe5 ! non-propriet>y br&s ( 8!obrom9 sodium salicylate0 & 8,diuret920 7#b7 ! sev]al specim5s exam9$ 7 n simple mixtures ( 8!obrom90 & 8sodium salicylate02 7#c7 ess5tially all ! br&s compli$ ) ! /&>ds laid d[n & c be rat$ z satisfactory2 7#d7 8,diuret910 ?\gh sold at an exorbitant price1 is n sup]ior to ! product suppli$ "u ! descriptive t]m 8!obrom9 sodium salicylate10 & 7#e7 8,diuret90 sells :olesale = #a4ge an ounce1 aga9/ #ce c5ts = ! 8!obrom9 sodium salicylate10 & !re=e its employm5t _c be int]pret$ o!rwise ?an z a useless & unnecess>y exp5se4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,april #d1 #aiad47 ,,ungu5t9e ,w4 ,a4 ,puckn] & ,a4 ,h4 ,cl>k ,att5tion has be5 call$ at v>i\s times to ! fact t ! value ( a publi%$ 8=mula0 to a propriet>y rem$y is 9 direct ratio to ! reliability ( ! manufactur] publi%+ x4 ,:5 m$ical j\rnals fir/ insi/$ on _! adv]tis]s lett+ physicians "k ! cont5ts ( ! rem$ies !y wi%$ to sell !m1 m$ical lit]ature reek$ ) =mulas--"s ( !m ( weird & wond]ful design4 ,s9ce ! adv5t ( ! ,food & ,drugs ,act1 :i* requires t labels %all approximate tru?fulness1 & p>ticul>ly s9ce ! ,c\ncil on ,ph>macy & ,*emi/ry has inve/igat$ a numb] ( propriet>y rem$ies1 ! publication ( 8=mulas0 is n s common4 ,ungu5t9e1 manufactur$ by ! ,norwi* ,ph>macal ,co41 is "o ( ^? rem$ies ^: adv]tisem5t = ye>s always includ$ 8a =mula02 m rec5tly1 h[ev]1 ?is is n 9 evid5ce4 ,9 an adv]tisem5t :i* appe>$ ab\t t5 ye>s ago1 ! 8=mula0 giv5 is3 8,c>bolic acid #b p] c5t4 8,i*?yol #e p] c5t4 8,alum #ae to #af p] c5t40 ,x 0 claim$ t1 by a special process ( _! own1 ! manufactur]s _h elim9at$ mo/ ( ! a/r+5t prop]ties ( ! alum1 r5d]+ x non-irritant4 ,x 0 also /at$ t 8! base ( ,ungu5t9e is pure petrolatum40 ,lat] ! manufactur]s seem to h *ang$ ! composition ( _! product1 or at lea/ ! 8=mula0 giv5 9 ! adv]tisem5ts 0 *ang$4 ,?us x appe>$3 8,alum #ae p] c5t4 8,z9c oxid #e p] c5t4 8,c>bolic acid #b p] c5t4 8,i*?yol #e p] c5t4 8,aromatics & antiseptic oils ) specially prep>$ petrolatum & animal fat base40 ,! introduction ( z9c oxid1 aromatic & antiseptic oils & animal fat 0 a new feature4 ,some:at lat]1 & p>ticul>ly s9ce ! passage ( ! national ,food & ,drugs ,act1 no =mula or o!r /atem5t reg>d+ ! composition seems to h appe>$ 9 ! adv]tisem5ts 9 ! m$ical press4 ,9 ! #aijf price-li/ 7p4 #agj7 ! foll[+ =mula appe>s3 8,ungu5t9e repres5ts3 8,alum 7non-irritat+7 #ae p] c5t4 8,ph5ol #b p] c5t4 8,i*?yol #e p] c5t4 8,z9c oxid #e p] c5t4 8,aromatic & antiseptic oils1 ) especially prep>$ petrolatum & purifi$ animal fat40 ,9 ! price-li/ issu$ = #aijh--;aft] ! ,food & ,drugs ,act w5t into effect--! foll[+ appe>s3 8,ungu5t9e repres5ts3 8,alum comp\nd 7non-irritat+7 8,ph5ol1 8,i*?yol1 8,z9c oxid1 8,aromatic & antiseptic oils1 ) especially prep>$ petrolatum & purifi$ animal fat40 ,?us ! proportions are omitt$1 & alum becomes 8alum comp\nd10 :atev] t may mean4 ,9 view ( ! conflict+ /atem5ts made by ! ,norwi* ,ph>macal ,company1 9 reg>d to _! lead+ specialty1 ,ungu5t9e1 & especially because mu* /ress 0 laid on ! fil+ ( _! 8gu>antee0 "u ! ,food & ,drugs ,act1 x 0 decid$ to asc]ta9 ( :at ,ungu5t9e really consi/s4 ,f our analysis we conclude t ,ungu5t9e conta9s n alum b alum9um acetate 7small am\nts ( alum may be pres5t z impurities 9 ! alum9um acetate71 z9c oxid1 or m probably impure z9c c>bonate1 & t ! entire quantity ( bo? does n exce$ #e p] c5t4 ,x conta9s no i*?yol1 or if any b ! m]e/ traces1 & less ?an #a p] c5t4 ( ph5ol4 ,! aromatic oils am\nt to n m ?an approximately #a p] c5t4 9 all4 ,! o9tm5t-base is1 9 ! ma91 petrolatum4 ,9 ,ungu5t9e we h1 !re=e1 ano!r propriet>y 8specialty10 reg>d+ ! composition ( :i* indef9ite1 false or mislead+ /atem5ts h be5 made--?is irrespective ( prote/ation ( hone/y by ! firm4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,m>* #bg1 #aiji47 ,,uric$9 ,w4 ,a4 ,puckn] & ,a4 ,h4 ,cl>k ,9 view ( ! results ( inve/igations by ,z]nik ( ,uric$9 z sold 9 ,g]many1 & because x is be+ adv]tis$ to physicians 9 ?is c\ntry1 an exam9ation ( ?is product 0 made 9 ! laboratory ( ! ,am]ican ,m$ical ,association4 ,z]nik's report %[s h[ ?is rem$y has v>i$ 9 its composition z put on ! m>ket 9 ,g]many4 ,f _! analysis ! au?ors f9d t ,uric$9 is n a def9ite *emical comp\nd z is claim$1 b is a simple mixture ^: composition is approximately3 ,sodium sulphate 7anhydr\s7 #fa4eb p] c5t4 ,sodium citrate 7anhydr\s7 #bi4fb p] c5t4 ,sodium *lorid #b4ac p] c5t4 ,citric acid 7anhydr\s7 #c4be p] c5t4 ,moi/ure #b4ec p] c5t4 ,undet]m9$ #j4ie p] c5t4 ------ #ajj4jj ,uric$91 !re=e1 is n a def9ite *emical comp\nd z claim$1 b a simple mixture :i* consi/s ess5tially ( sodium sulphate 7dri$ ,glaub] salt7 #b_/c1 & sodium citrate #a_/c4 ,x is1 !re=e1 a typical no/rum1 &1 z x appe>s1 "o ! composition ( :i* is *ang$ f "t to "t to suit ! :im ( ! manufactur]4 ,! !rapeutic claims made = x are ( ! usual extravagant "*4 ,accord+ to a rec5t adv]tisem5t x is 8us$ successfully = ,g\ty ,dia!sis1 ur9>y ,calculi1 ,rheumatoid ,ar?ritis10 8useful 9 ,migra9e1 ,occipital ,heada*e1 ,epilepsy1 ,hay ,fev]1 ,a/hma10 etc4 ,if su* a simple mixture w d all t ?is "o is claim$ to d1 let u use x1 b prescribe its +r$i5ts "u _! prop] names4 ,su* a mixture w\ld co/ only a few c5ts a p\nd1 b ?is no/rum is li/$ at #a4be a bottle ( five ounces1 or probably #a4ge at retail1 & ?is = ! b5efit ( its =eign manufactur]s & _! ag5ts4--7,ab/ract$ f ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #bc1 #aijg47 ,,urisept9 ,w4 ,a4 ,puckn] & ,w4 ,s4 ,hilp]t 8,urisept910 manufactur$ by ! ,g>dn]-,b>ada ,*emical ,co4 ( ,*icago & claim$ to be a 8ur9>y antiseptic1 uric acid solv5t & diuretic10 0 exam9$ 9 ! laboratory ( ! ,am]ican ,m$ical ,association to det]m9e to :at ext5t ! claims made = x are ju/ifi$4 ,! prep>ation z pur*as$ 9 ! op5 m>ket be>s a label :i* pres5ts ! claims ( ! manufactur]s1 emphasiz$ by ! *emical analysis duly sign$ by an analy/ & atte/$ by a not>y4 ,accompany+ is a reproduction ( "p ( ! label4 ,illu/ration3 ---------------------------------------- ---------- ,,analysis ,sample ( 8,urisept90 manufactur$ by ! ,g>dn]-,b>ada ,*emical ,co41 ,*icago4 ,ill41 0 f\nd to conta93 ,specific ,gravity at #ae4e ,c #a4jgaf ,total ,solids #bj4db p4c4 ,alcohol 7,e?yl7 #g4ff p4c4 ,wat] 7by ,diff]5ce7 #ga4ib p4c4 ,total ,a% #a4df p4c4 ,li?ium ,oxide #j4ej p4c4 ,=maldehyde #e4fb p4c4 ,acidity #ajj cc equals #f4d cc ,normal ,alkali4 ,sug>s ,pres5t ,c\* ,grass ,extract ,pres5t ,corn ,silk ,extract ,pres5t ,! ,total ,solids consi/ ma9ly ( ! sug>s & extract ( corn silk & c\* grass4 ,! c\* grass & corn silk extracts 7 det]m9$ by ta/e & smell 9 comp>ison ) au!ntic samples ( same products4 ,! ,li?ium ,oxide & ! ,=maldehyde are 9 comb9ation 9 ! ,urisept9 & toge!r repres5t #bf4gg gra9s p] liquid oz4 ,i rema91 ,y\rs v truly1 7,sign$7 ,dr4 ,edwd4 ,gudeman4 ,/ate ( ,ill9ois ss4 ,c\nty ( ,cook ,subscrib$ & sworn to be=e me ?is #ac? day ( ,may1 #aije4 7,sign$7 ,paul ,e4 ,bu$efeldt1 ,not>y ,public4 ---------------------------------------- ---------- ---------------------------------------- ----------- ,,urisept9 ---------------------------------------- ----------- ,,=mula 7,see analysis74 ,ea* fluid ounce ( ,urisept9 conta9s ,=maldehyde comb9$ ) ,li?ium dissolv$ 9 conc5trat$ liquid extract ( ,corn ,silk & ,c\* ,grass1 & w lib]ate a suffici5t quantity ( ,=maldehyde 7#bd gra9s7 to impregnate ! daily secretion ( ur9e 7#de-ej fluid ounces7 to a #a-ajjj solution4 ,,prop]ties ,ur9>y ,antiseptic4 ,uric ,acid ,solv5t4 ,diuretic4 ,,indications ,diseases ( ! ur9>y tract & _! complications--,nephritis1 ,pyelitis1 ,ure?ritis1 ,gonorrhea1 ,gleet1 ,cy/itis1 ,bact]iuria1 ,uremia1 ,phosphaturia1 ,pro/atitis4 ,diseases dep5d5t on uric acid dia!sis--,g\t1 ,rheumatism1 ,calculus1 ,a/hma & g5]ally z an antiseptic & uric acid solv5t4 ,,dose ,tablespoonful night & morn+1 or "o to two teaspoonfuls f\r times a day1 pref]ably 9 hot wat]4 ---------------------------------------- ----------- ,r$uc$ photographic reproduction ( "p ( ! ,urisept9 label4 ,be=e ! exam9ation _h ext5d$ v f> x 0 f\nd t discrepancies exi/$ betwe5 facts & claims1 & by ! "t ! analysis 0 complete ,urisept9 0 f\nd to be 9 ! same class z _m o!r propriet>y rem$ies t h be5 discuss$ 9 ^! columns4 ,our exam9ation %[s t ! mo/ mislead+ /atem5t is t conc]n+ ! 8li?ium-=maldehyd0 comp\nd ! pres5ce ( :i* is claim$1 m or less directly1 by bo? ! manufactur]s & ! analy/ employ$ by ! manufactur]s4 ,al?\gh ! *emical prop]ties ( li?ium & =maldehyd indicate 9 !mselves t ! exi/5ce ( su* a comp\nd w\ld be mo/ improbable1 yet consid]able "t 0 sp5t 9 se>*+ ! *emical lit]ature = su* a comp\nd4 ,?or\gh se>*1 h[ev]1 demon/rat$ t no su* comp\nd1 nor any t ev5 approximat$ x1 has be5 describ$4 ,! "q !n arose z to ! =m 9 :i* ! li?ium & ! =maldehyd are pres5t4 ,! /atem5ts reg>d+ its prop]ties z a ur9>y antiseptic & ! fact t ! prep>ation is said to lib]ate =maldehyd sl[ly 9 ! bladd] po9t /rongly to ! pres5ce ( hexame?yl5am94 ,te/s#ajb 7 appli$ to demon/rate :e!r ! =maldehyd 0 pres5t z a li?ium comp\nd1 & if n1 :e!r x exi/$ 9 ! =m ( hexame?yl5am94 ,by ^! ! pres5ce ( hexame?yl5am9 0 prov$ & ! abs5ce ( =maldehyd 9 o!r comb9ations demon/rat$4 ,?is fact alone %[s t ! prep>ation is delib]ately m>ket$ "u a false claim1 & x %[s fur!r t ! analysis on ! label is wor?less4 ,! quantitative me?od ( analysis demon/rat$ ! pres5ce ( #e4ea gm4 hexame?yl5am9 p] #ajj c4c4 7#be4ae gra9s p] fluid\nce74 #ajb ,^! appe> 9 ! annual report = #aijh ( ! ,*emical ,laboratory ( ! ,am]ican ,m$ical ,association2 !y 7 also publi%$ 9 full 9 ,j\r4 ,am4 ,*em4 ,soc41 ,septemb]1 #aijh2 an outl9e ( ! analysis appe>$ 9 ,! ,j\rnal ,a4 ,m4 ,a41 ,aug4 #bi1 #aijh4 ,besides ! hexame?yl5am91 ,urisept9 conta9s li?ium & a b5zoate4 ,conc]n+ ! latt] no?+ is said 9 ! analysis1 ^: wor?lessness is aga9 demon/rat$4 ,by quantitative me?ods ,urisept9 0 f\nd to conta9 li?ium & a b5zoate 9 su* proportions z w\ld indicate t ! li?ium & ! b5zoate radicle exi/ z li?ium b5zoate4 ,?is fact is fur!r indicat$ by ! claims made = ! prep>ation reg>d+ its prop]ties z a uric acid solv5t1 = :i* purpose li?ium b5zoate is (t5 us$4 ,aga91 ! demon/ration t ! =maldehyd pres5t is 9 comb9ation z hexame?yl5am9 preclud$ any possible *emical comb9ation betwe5 li?ium & =maldehyd & adds ano!r /rong po9t 9 support ( ! conclusion t ! li?ium & b5zoic acid are 9 comb9ation z li?ium b5zoate4 ,,conclusion ,by *emical analysis ! active +r$i5ts ( ,urisept9 are %[n to be hexame?yl5am91 approximately #e4e gm4 p] #ajj c4c4 7ab\t #be gr4 to ea* fluid\nce71 & li?ium b5zoate1 approximately #j4gj gm4 p] #ajj c4c4 7ab\t #aa gra9s to ea* fluid\nce71 nei!r ( :i* comp\nds is m5tion$ 9 ! adv]tis+ matt] on ! label or 9 ! s-call$ 8analysis0 on ! label4 ,! /atem5ts conc]n+ ! composition ( ,urisept9 are false & appe> to be a delib]ate attempt to mislead physicians4 ,comm5t4--,inve/igation ( ! v>i\s 8pat5t0 & s-call$ 8e?ical propriet>ies0 adv]tis$ to ! public & to ! m$ical pr(ession %[s t ^? t h any value z !rapeutic ag5ts dep5d = t value on "s well kn[n drug or drugs4 ,h5ce1 :ile _m propriet>ies h "s virtue1 ! +r$i5ts :i* are ( any value are s conceal$ by ! co9$ & 8ne>-sci5tific0 names appli$ to !m t ^! drugs are usually unrecognizable4 ,! _m & v>i\s acetanilid mixtures furni% examples ( ?is class ( propriet>ies4 ,& n[ we f9d ano!r example 9 t mu* adv]tis$ no/rum1 ,urisept94 ,accord+ to our *emi/s1 ! *ief +r$i5ts ( ,urisept9 are hexame?yl5am9 & li?ium b5zoate4 ,hexame?yl5am9 is a valuable s-call$ ur9>y antiseptic--probably "o ( ! be/ we h4 ,x is a pity t m physicians d n "k ! value ( ?is drug 9 & ( itself2 x is a common +r$i5t ( _m propriet>ies1 & yet too seldom prescrib$ "u its true "n4 ,!re is no reason = its be+ giv5 9 ! =m ( a no/rum2 x requires no skill 9 comp\nd+1 = x is be/ giv5 9 its p[d]$ =m1 ei!r 9 capsules or o!rwise4 ,s t1 l acetanilid1 ! old argum5t ( ! no/rum m5 t ! prep>ation ne$s skill 9 comp\nd+ w n hold4 ,if a physician wants to prescribe hexame?yl5am9 let him prescribe x 9 its simple/ & be/ =m1 & ?us "k exactly :at he is giv+4 ,li?ium b5zoate also has its rightful place 9 ! mat]ia m$ica1 b n hidd5 9 a propriet>y mixture to be prescrib$ unkn[+ly4 ,x is h>d to conceive ( any "o ?+ t op]ates m disa/r\sly aga9/ sci5tific !rapeutics ?an ! vici\s practice ( m>ket+ "u propriet>y names /&>d & valuable drugs1 ) _! id5tity purposely conceal$4 ,yet h[ frequ5tly x is done4 ,well-kn[n drugs ( unque/ion$ wor? are comb9$ ) ^? t are little kn[n & ( d\btful value1 or m likely absolutely wor?less1 ! mixture is put on ! m>ket "u a high-s\nd+ "n & x is exploit$ ?r\gh physicians z a panacea = all k9ds ( diseases4 ,9 ?is1 z 9 s _m o!r in/ances1 an 8analysis0 made to ord] is giv5 to l5d an air ( app>5t respectability & sci5tific /&+ to ! prep>ation or to its exploit]s1 ) ! object1 ( c\rse1 ( mislead+ physicians into ?9k+ !y are read+ unbias$ te/imony4 ,9 addition1 ! 8lit]ature0 accompany+ ! prep>ation is usually a j>gon ( pseudo-sci5tific v]biage put 9 to s]ve ! same purpose z ! analysis--t ( cat*+ ! c>eless physician4 ,?is /ate ( affairs w cont9ue j s long z ! m$ical pr(ession w tol]ate x--& no long]4 ,s long z memb]s ( our pr(ession w prescribe propriet>ies on ! /atem5ts ( _! own]s--z to bo? _! composition & _! !rapeutic value--j s long w pseudo-*emical & pseudoph>maceutical companies fatt5 at ! exp5se ( ! m$ical pr(ession & to ! detrim5t ( ! public heal?4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,aug4 #bi1 #aijh47 ,,zemacol ,w4 ,a4 ,puckn] & ,w4 ,s4 ,hilp]t ,att5tion has be5 call$ to ! vague & my/]i\s /atem5ts reg>d+ a prep>ation call$ ,zemacol1 manufactur$ by ! ,norwi* ,ph>macal ,co41 ,norwi*1 ,n4 ,y4 ,because ( ! unsatisfactory /atem5ts reg>d+ ! composition ( ! prep>ation1 x 0 consid]$ ( suffici5t int]e/ to make an analysis & det]m9e its *emical con/itu5ts4 ,accord+ly specim5s ( ! prep>ation 7 obta9$ & exam9$4 ,! prep>ation ,zemacol 7,norwi* ,ph>macal ,co471 z f\nd on ! m>ket1 is a ?ick1 p9k1 mucilag9\s liquid1 highly p]fum$ & hav+ besides a sugge/ion ( a ph5olic odor4 ,! bottle be>s a label on :i* appe> ! foll[+ /atem5ts3 8,a colloidal emolli5t conta9+ extract ( ! rete mucosum ( ! heal?y ye>l+ lamb1 comb9$ ) glyc]91 salicylic acid & o!r antiseptic & aromatic oils4 ,useful 9 eczema & diseases ( ! integum5t :]e cell de/ruction is a prom95t factor40 ,9 ! adv]tis+ matt] ! foll[+ claims are made3 8,an advance 9 animal !rapy44440 8444 increases ! nutritive activity ( ! cell tissue ( ! sk9 ?r\gh ! absorbable extract ( ! rete mucosum40 8444 cl9ical te/s %[ its efficacy 9 bo? ! s-call$ moi/ & dry eczemat\s conditions ( all p>ts ( ! cutane\s surfaces40 8444 ri* 9 animal cells40 ,s9ce no?+ c\ld be f\nd 9 ! lit]ature reg>d+ ! !rapeutic action ( an extract ( ! rete mucosum ( ! %eep1 x 0 ?\ght possible t ! /atem5ts on ! label 7 giv5 simply z a vague & my/]i\s means ( indicat+ ! pres5ce ( wool-fat 7lanol971 & te/s 7 made to det]m9e ! pres5ce or abs5ce ( ! latt] sub/ance4 ,a sub/ance 0 isolat$ f ,zemacol :i* _h ! physical prop]ties (1 & respond$ to "s ( ! *emical te/s =1 wool-fat2 b x 0 f\nd 9 su* small quantities z to indicate t x 0 n pres5t z an active con/itu5t4 ,s9ce !re are no def9ite te/s = ! detection ( s]ums or animal extracts ! pres5ce or abs5ce ( ^! c\ld n be demon/rat$4 ,fur!r exam9ation indicat$ ! pres5ce ( salicylic acid1 a gummy mat]ial1 hav+ ! prop]ties ( tragacan? & glyc]94 ,x is practically free f inorganic matt]4 ,by di/illation a small quantity ( oil 0 isolat$1 :i* possesses ! *>act]i/ic odor ( ! prep>ation4 ,quantitative e/imations#ajc indicat$ ! pres5ce ( ! above-m5tion$ con/itu5ts 9 approximately ! foll[+ quantities3 #ajc ,details ( ?is analysis appe> 9 ! annual report = #aiaj ( ! ,*emical ,laboratory ( ! ,am]ican ,m$ical ,association4 ,p] ,c5t4 ,gummy matt] hav+ ! prop]ties ( tragacan? #b4jb ,salicylic acid #j4fg ,matt] hav+ ! g5]al prop]ties ( wool-fat 7lanol97 #j4bj ,glyc]9 #e4ej ,volatile matt] 7wat] & alcohol7 #ia4jj ,aromatic oils & ph5ol-l bodies ,trace ,! results ( ! above analysis1 toge!r ) adv]tis+ matt] reg>d+ ,zemacol1 7 submitt$ to ,dr4 ,william ,all5 ,pusey1 pr(essor ( d]matology & cl9ical d]matology1 ,college ( ,physicians & ,surgeons1 ,*icago1 & pa/ *airman ( ! ,section on ,d]matology ( ! ,am]ican ,m$ical ,association1 ) ! inquiry :e!r or n !re 0 any record ( inve/igations reg>d+ ! !rapeutic value ( an extract ( ! rete mucosum ( ! %eep & :e!r 9 8 op9ion ! claims made = ,zematol w\ld be w>rant$4 ,! foll[+ reply 0 receiv$3 8,s f> z ,i "k1 nobody ev] ?\ght ( or propos$ ! use ( an extract ( rete mucosum z a !rapeutic ag5t & if a s]i\s sugge/ion ( t sort _h ev] be5 made ,i believe ,i w\ld "k x4 ,i c conceive ( no s]vice :i* su* an extract c\ld r5d] & ,i ?9k ! sugge/ion ( x is a highly fanta/ic idea4 ,f ! analysis :i* y furni% ,i %\ld say t ! mixture describ$ is sub/antially ! ord9>y #b p] c5t4 solution ( tragacan? 9 glyc]9 & wat] ) a little antiseptic add$ to keep x f decompos+4 ,t is a commonly kn[n lotion1 modifications ( :i* are us$ 9 practically e hospital z a h& lotion1 & has no magical virtues :atev]4 ,incid5tally1 ,i %\ld ?9k x co/1 aside f ! labor1 ab\t tw5ty c5ts a gallon to make x40--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,may #ad1 #aiaj47 ,,zyme-,,oid ,w4 ,a4 ,puckn] & ,w4 ,s4 ,hilp]t ,zyme-oid1 manufactur$ by ! ,oxy*lor9e ,*emical ,company ( ,*icago1 is adv]tis$ z 8a p[]ful ga/ro-inte/9al antif]m5t0 :i* w 8arre/ & prev5t bact]ial f]m5tation 9 any portion ( ! inte/9al tract1 :e!r ! m$ia be acid or alkal9e40 ,^! extravagant /atem5ts1 l _m o!rs made reg>d+ ! prop]ties ( zyme-oid1 are v simil> 9 "* to ^? made 9 ! circul>s accompany+ ! prep>ation oxy*lor9e1 manufactur$ by ! same firm & expos$ 9 ,! ,j\rnal1 ,july #f1 #aijg1 page #ed4 7,see page #adg ( ?is book47 ,z examples1 sev]al p>allel /atem5ts help to %[ ?is simil>ity4 ,! =mula 787 ( oxy*lor9e1 z exp\nd$ on ! label1 is giv5 9 full1 :ile 9 ! case ( zyme-oid only a h9t is giv5 z to its composition1 b /ill suffici5t to po9t to a simil>ity betwe5 ! two3 ,,oxy*lor9e ,,zyme-,,oid 8,oxy*lor9e is a tetraborate 8,zyme-,oid is a d\ble borate ( sodium & potassium com- salt40 b9$ ) oxy*lorid ( boron1 ?us3 7#f,na,k,b#d,o#g7 ,b,o,cl#c40 ,9 ! matt] ( claims = *emical /ability ! two seem to be v closely alli$3 ,oxy*lor9e is 8a /able salt ,zyme-oid is 8a product :i* is "u all conditions until /able en\gh = keep+ pur- br\ght 9 contact ) sub- poses1 b :i* readily yields oxyg5at$ organic matt]40 nasc5t oxyg5 9 ! pres5ce ( bact]ial products40 ,! !rapeutic prop]ties attribut$ to ^! si/] products are ev5 m simil>1 = we f9d t3 8,oxy*lor9e is adapt$ to all 8,zyme-oid is a p[]ful ga/ro- morbid & abnormal f]m5tative inte/9al antif]m5t40 alim5t>y /ates40 ,_m m /atem5ts & claims c\ld be quot$ to %[ a simil>ity betwe51 am\nt+ almo/ to an id5tity (1 oxy*lor9e & zyme-oid4 ,) ^! facts 9 m9d1 ! analysis ( zyme-oid 0 und]tak5 9 ord] to comp>e x ) ! previ\sly exam9$ oxy*lor9e & to det]m9e to :at ext5t ! claims made = zyme-oid are upheld by its composition4 ,! analysis indicat$1 z 0 expect$1 t zyme-oid is ess5tially ! same z oxy*lor9e z is %[n 9 ! foll[+1 quot$ f ! report ( ! analysis ( ea*3 ,,analysis ,,( ,,oxy*lor9e ,,analysis ,,( ,,zyme-,,oid ,potassium 7,k7 #ab4bf ,potassium 7,k7 #ac4ej ,sodium 7,na7 #h4bj ,sodium 7,na7 #i4hd ,*lorate 7,cl,o#c7 #be4cb ,*lorate 7,cl,o#c7 #bg4ej ,nitrate 7,,no#c7 #ba4gj ,nitrate 7,,no#c7 #bd4bb ,boric acid anhydrid ,boric acid anhydrid 7,b#b,o#c7 #ah4fc 7,b#b,o#c7 #ac4db ,wat]1 calculat$ #ac4bi ,wat]1 calculat$ #aj4db ,assum+ t ! *lorate 9 zyme-oid is pres5t z potassium *lorate & ! nitrate is pres5t z sodium nitrate1 ! figures obta9$ by analysis correspond to a mixture approximately z foll[s3 ,potassium *lorate 7,k,cl,o#c7 #dj4dc ,sodium ,nitrate 7,na,n,o#c7 #cc4bb ,potassium tetraborate 7,k#b;,b#d,o#g7 #a4fj ,sodium tetraborate 7,na#b;,b#d,o#g7 #c4ca ,boric acid #ba4ad ,f ! results ( ! analysis & f ! physical prop]ties ( zyme-oid we conclude1 j z 0 done 9 ! case ( oxy*lor9e1 t ! prep>ation is n a def9ite *emical comp\nd1 b is ess5tially a mixture ( alkali *lorate & nitrate ) boric acid1 probably produc$ by fus+ toge!r ! con/itu5ts4 ,,comm5t ,an exam9ation ( ! claims made = ! firm's two products1 :ile1 z already prov$1 disclos+ _m po9ts ( simil>ity1 w also %[ "o rem>kable diff]5ce4 ,we ref] to ! skilful indef9it5ess t p]vades ! claims made = zyme-oid & :i* defies sci5tific refutation4 ,?is v]bal obscurity is becom+ daily m common 9 ! 8lit]ature0 ( firms m>ket+ no/rums4 ,s9ce ! ,c\ncil has analyz$ _m ( ! mu*-adv]tis$ articles & prov$ ! unreliability ( ! pseudo-sci5tific claims made = !m1 ! m cauti\s ( ! no/rum-mong]s h modifi$ ! matt] descriptive ( _! products4 ,!y h call$ to _! aid ! pr9ciple t words 7 giv5 to man to conceal ?\ght r ?an to express x1 & !y h r$uc$ equivocation to a f9e art4 ,:]ev] x 0 possible to put =w>d claims by implication r ?an by expression ?is has be5 done4 ,to sub/antiate fur!r ! claims made by ! manufactur]s ( zyme-oid = _! product1 a laboratory report is br\ght 9 evid5ce4 ,?is report1 :i* is writt5 m 9 ! /yle ( a p]una te/imonial ?an t ( a cons]vative sci5tific /atem5t1 fails to v]ify ! claim t zyme-oid is a 8d\ble borate salt10 b conf9es itself to a /atem5t ( its h>mlessness & its anti-f]m5tative prop]ties4 ,9 pass+1 x seems regrettable t sci5tific laboratories %\ld1 = a pecuni>y consid]ation1 be will+ to jeop>dize _! reputations by l5d+ _! names to ! fur!rance ( no/rum exploitation4 ,! results ( ! exam9ation ( zyme-oid demon/rate t ! product is no m wor?y ( ! physician's consid]ation ?an its close1 & equally wor?less1 relative1 oxy*lor9e4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,may #bc1 #aijh47 ,,"p ,,iii ,,contributions ,,f ,,! ,,j\rnal3 ,,no/rums ,,alleotone ,! =mula ( ?is prep>ation1 giv5 9 ! lit]ature1 reads z foll[s3 ,alcoholici 7,monatomic7 gr4 #a_/ajjj ,qu99 ,sulphatis gr4 #a_/chd ,ac4 ,sulph4 ,dil4 7#aj p] c5t47 gtt4 #b-a_/b ,ac4 ,nitrici ,dil4 7#aj p] c5t47 gtt4 #a_/gg ,ac4 ,butanol-,dioic gr4 #a_/c ,tr4 ,f]ri ,*loridi gtt4 #a_/bf ,aqu gtt4 xx ,! =mula is wor?less4 ,x c only mislead & my/ify & ! great] "p ( ! lit]ature is a m]e jumble ( inaccurate & my/ify+ /atem5ts4 ,! v>i\s con/itu5ts ( ! prep>ation are tak5 up z foll[s4 ,! adv]tis+ lit]ature /ates3 8,monatomic ,alcohol is "o ( ! con/itu5ts ( all n]ve tissue3 ,x is a product ( ! replacem5t ( "o atom ( hydrog5 ( ! hydroc>bons by _! hydroxyl gr\p ,h4,o40 ,?is in=mation does n in=m1 s9ce !re is a va/ numb] ( monatomic alcohols & ( e description4 ,! ass]tion t ! prep>ation 8conta9s a salt0 w\ld be p]fectly analog\s & j z enlight5+4 ,( 8,f]ri ,*lo0 ! lit]ature says3 8,f]ri ,*lo is f\nd ) all proteids & nucle9s & h]e9 acts z magnetic iron1 aid+ ! play ( ! electrical travel40 ,! fir/ ass]tion is untrue1 = iron does n exi/ z *lorid 9 ! cells ( ! body1 b z "s organic iron comp\nd2 nei!r is x f\nd 9 all proteids1 b pr9cipally 9 nucleo-album9s2 & n all proteids conta9 nucleo-album9s4 ,! ass]tion t ! iron *lorid 8acts z magnetic iron aid+ ! play ( ! electric travel0 is nons5sical & on a p> ) ! electric belt me?od ( exploitation1 & sugge/s =cibly ! class to :i* ,alleotone belongs4 ,! lit]ature fur!r /ates3 8,sulphuric & nitric acids act 9 remov+ hydrog5 atoms & sub/itute atoms ( ! radical ,,no#b2 t is1 z hydrog5 tranquilizes ! spe$ ( burn+ or oxidation1 its action is sub/itut$ by ! atom nitrog5 :i* is en]gy itself1 nitrog5 be+ ! base ( all explosives40 ,sulphuric acid is c]ta9ly an oxidiz+ ag5t & 9 virtue !re( removes hydrog52 b n 9 a solution ^: conc5tration ) respect to sulphuric acid is approximately only #j4hb p] c5t4 ,! /atem5t t nitrog5 is ! 8base ( all explosives0 is ano!r example ( ! me?ods ( ! promot]s4 ,z x is a well-kn[n fact1 h[ev]1 t nitrog5 itself is "o ( ! lea/ reactive ( gase\s elem5ts1 little confid5ce c be plac$ 9 su* rem>ks z 8,nitrog5 :i* is en]gy itself40 ,ano!r my/ify+ t]m us$ 9 ! =mula is 8,ac4 ,butanol-,dioic10 :i* is a true *emical "n1 c]ta9ly1 b x is "o by :i* few physicians w recognize simple malic acid1 an ord9>y vegetable acid widely di/ribut$ 9 ripe fruits1 su* z apples & pe>s1 & possess+ ! prop]ties simply ( a relatively weak organic acid4 ,to describe x z ex]cis+ any pot5t influ5ce 89 ! oxidation ( ! phosphorus z leci?9 9 ! cell0--especially 9 ! extremely l[ conc5tration 9 :i* x is /at$ to exi/ 9 ,alleotone--is simply an absurd juggl+ ) words4 ,x is n mu* to be wond]$ at t ! public %\ld be tak5 9 by pseudosci5tific 8lit]ature02 b x is n only /range1 x is discr$itable to our pr(ession1 t among its memb]s %\ld be f\nd any to accept su* rubbi% z ! above quot$ 8lit]ature0 z in=mation wor? act+ on--yet su* !re are1 judg+ f ! te/imonials4--7,ab/ract$ f ,! ,j\rnal ,a4 ,m4 ,a41 ,feb4 #a1 #aijh47 ,! ,comm]cial ,value ( ,adv]se ,criticism ,= skilful attempts to conv]t a 8knock0 into a 8boo/10 comm5d u to ! discr$it$ no/rum exploit]4 ,! f$]al ,food & ,drugs ,act did mu* to br+ out ?is amiable quality--possibly develop$ x4 ,:ile some:at anci5t hi/ory1 x is well to call to m9d :at happ5$ :5 ! excise au?orities insi/$ ei!r t ! 8pat5t m$ic9e0 booze1 ,p]una1 h "s m$ic9e put 9 x1 or else t its manufactur]s %\ld g into ! saloon bus9ess4 ,h>tman at once got out a new label /at+ t 8= a numb] ( ye>s a multitude ( grateful fri5ds0 _h urg$ 8t ,p]una be giv5 a slight laxative quality40 ,!nce=? ! innoc5ts & ne>-innoc5ts c\ld get _! p]unaese jag only at ! risk ( a 8bad qu>t] ( an h\r40 ,"o ( ! late/ attempts to wriggle out ( an uncom=table position1 & at ! same "t make capital out ( ! wriggl+1 is se5 9 ! adv]tis+ ( ,alleotone1 a no/rum ( ! pseudosci5tific type1 :i* 0 %[n up 9 ,! ,j\rnal ( ,feb4 #a1 #aijh4 ,! 8=mula0 furni%$ is = ! mo/ "p a j>gon ( mislead+ & my/ify+ nons5se & fulfils ! same purpose z ! voluble 8patt]0 ( ! g5tleman :o is manipulat+ ?ree %ells & a pea at ! c\nty fair4 ,e con/itu5t ( ! 8=mula0 0 discuss$ 9 ,! ,j\rnal & ! absurdities & impossibilities ( ea* dwelt on4 ,did ! manufactur]s ( ,alleotone feel d[nca/ ov] ! exposure ( _! humbug8 ,n to judge by _! adv]tis+1 = !y write to physicians t 8s9ce ! ,a4 ,m4 ,a4 analyz$ ,alleotone x has made great /rides0--direction n specifi$4 ,b ! *oice/ piece ( impud5ce1 & "o t b = its di%one/y w\ld be laughable1 is f\nd 9 ?is portion ( _! adv]tis+ pamphlet3 ,illu/ration ,9 ! orig9al1 ! words 8,) am5dm5ts sugge/$ 9 ! ,j\rnal ( ! ,am]ican ,m$ical ,association1 ,feb4 #a1 #aijh10 & also 87,*ole/]9470 & 87,malic ,acid4710 :i* we h und]scor$ 9 ! illu/ration1 are pr9t$ 9 r$ & h be5 add$ to ! orig9al 8=mula40 ,su* are ! uses ( adv]sity4 ,:at claim1 if any1 ! exploit] ( ?is no/rum--,b4 ,f4 ,copel&--has to m$ical or ph>maceutical k1 we d n "k4 ,9 fact1 to be consi/5t ) ! 8e?ics0 ( ! no/rum bus9ess he ne$ h none4 ,su* k1 inde$1 t5ds to hamp] t free play ( ! imag9ation s necess>y 9 ?is "w4 ,we und]/& t he has at diff]5t times be5 9 *>ge ( a /ave factory & connect$ ) a brok]age firm1 :i* may ex]t "s subtle influ5ce 9 develop+ ! ability to relieve suff]+ humanity1 ?\gh ! connection is n q cle>4 ,"o w\ld imag9e1 h[ev]1 t ! ke5 bus9ess in/9ct1 untrammel$ by any consid]ations ( consci5ce1 :i* is exhibit$ 9 ! exploitation ( ,alleotone1 w\ld 9 purely comm]cial pursuits h long s9ce assur$ a compet5ce4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,oct4 #ag1 #aijh47 ,,baume ,,analgesique ,,b5gue ,a physician writes ask+ = ! =mula ( ,baume ,analgsique ,b5gu4 ,?is product is ano!r ( ! 8pat5t-m$ic9e0-8e?ical-propriet>y0 type ( no/rums4 ,9 ,great ,brita91 x is adv]tis$ to ! public z 8,a ,wond]ful ,rem$y = ,rheumatism1 ,g\t1 ,neuralgia40 ,9 ?is c\ntry1 ! exploit]s f9d t space 9 *eap m$ical j\rnals1 re9=c$ by ! aid ( undiscrim9at+ physicians1 is a *eap] me?od ( gett+ ! /uff to ! public4 ,accord+ to ! /atem5ts ( ! manufactur]s1 ,b5gu's ,analgesic ,balm conta9s 8m5?ol1 salicylate ( me?yl & lanol940 ,:5 analyz$ by ! *emi/s ( ! ,briti% ,m$ical ,association1 x 0 report$ to h ! foll[+ composition3 ,m5?ol #ah p] c5t4 ,me?yl salicylate #bj p] c5t4 ,lanol91 anhydr\s #ed p] c5t4 ,a fat1 app>5tly l>d #h p] c5t4 ,! e/imat$ co/ ( ! +r$i5ts ( a #ej-;c5t tube ( ,b5gu's ,analgesic ,balm1 accord+ to ! ,briti% *emi/s1 is #b-a_/b c5ts4 ,evid5tly ?is impos+ly nam$ product is practically a lanol9 o9tm5t conta9+ oil ( w9t]gre5 & m5?ol4 ,simil> products are catalogu$ by v>i\s ph>maceutical h\ses "u v>i\s names & ) v>y+ degrees ( frankness conc]n+ _! composition4 ,two firms give ! m$ical pr(ession full details reg>d+ ! composition ( _! products3 ,! ,h4 ,k4 ,mul=d ,company1 :o sell x "u ! "n 8,me?yl ,salicylate ,o9tm5t10 & ! ,pitman-,my]s ,co41 :o "n _! product 8,anodyne ,balm1 ,p-,m ,co40 ,"s o!r firms are n s frank4 ,p>ke1 ,davis ,co41 = in/ance1 sell 8a comb9ation ( me?yl salicylate & m5?ol ) a lanol9 base0 "u ! "n 8,analgesic ,balm10 b d n give ! quantities ( ! +r$i5ts2 ,fr$]ick ,/e>ns ,co4 sell 8,analgesic ,cream1 ,/e>ns0 )\t giv+ ! quantities2 ,nelson ,bak] ,co4 sell 8,anti-,neuralgic ,o9tm5t10 & no quantities are giv54--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,dec4 #ad1 #aiab47 ,,antidiabeticum--,,bau] ,9 ,g]many ! mak]s ( no/rums1 _! me?ods & _! products are sy/ematically expos$ by ! ,society = ! ,suppression ( ,quack]y 7,deuts*e ,gesells*aft zur ,bekmpfung des ,kurpfus*]tums7 ?r\gh its publication1 ! ,geseundheitslehr]1 "u ! aggressive editor%ip ( ,dr4 ,kantor4 ,ludwig ,bau]1#ajd ! manufactur] ( 8,antidiabeticum10 ins]t$ adv]tisem5ts 9 daily pap]s ass]t+ t = 8 8humanit>ian ef=ts0 ! society 8,op]a ,educativa pacifica0 9 ,rome _h grant$ him a diploma & plac$ 8 publications 9 ! celebrat$ 8,biblio!ca ,m>ciazzi40 ,dr4 ,kantor1 editor ( ! ,gesundheitslehr]1 decl>$ t1 accord+ to in=mation receiv$ f ! ,g]man ,consulate 9 ,rome1 no su* society exi/$ !re1 & ! libr>y ref]r$ to probably 0 ! ,biblio!ca ,m>ciana 9 ,flor5ce1 :i*1 l o!r public libr>ies1 accepts all donations )\t critical exam9ation4 ,to (fset ^! exposures1 ! promot] ( ,antidiabeticum publi%$ adv]tisem5ts libel+ ,dr4 ,kantor & attack+ ! ,society = ,suppression ( ,quack]y4 ,?is result$ 9 suits & c\nt]-suits = libel betwe5 ,dr4 ,kantor & ! directors ( ! antiquack]y society on ! "o side & ! promot] ( ,antidiabeticum on ! o!r4 ,z a result ( ! rec5t comb9$ trial1 ! c\rt decl>$ t ,dr4 ,kantor's *>ges _h be5 sub/antiat$ & ! manufactur] ( ,antidiabeticum 0 f9$ #fjj m>ks or =ty days' imprisonm5t1 :ile app>5tly on purely te*nical gr\nds ,dr4 ,kantor 0 f9$ #ej m>ks or five days' imprisonm5t4 ,! co/s 7 divid$ betwe5 ,bau] & ,dr4 ,kantor 9 ! proportion ( #aa to #a4 ,z ,bau] 9 ! c\rse ( ! trial made fur!r libel\s *>ges1 ,dr4 ,kantor has lately />t$ new proce$+s aga9/ ,bau]4 ,! incessant p]secution ( ,dr4 ,kantor 0 describ$ 9 an editorial 9 ,! ,j\rnal1 ,may #bj1 #aiaa1 p4 #adhf4 #ajd ,accord+ to a report 9 ! ,allgeme9e m$iz9is*e ,c5tral-,zeitung ,jan4 #f1 #aiab1 p4 #ad4 ,! p]secution ( ,dr4 ,kantor previ\sly describ$ %[s no signs ( abatem5t nor has ,dr4 ,kantor giv5 evid5ce ( loss ( c\rage4 ,"s ( ! ,g]man m$ical societies h subscrib$ = ! ,gesundheitslehr] = ea* ( _! memb]s4 ,x is writt5 9 popul> /yle = ! masses & is a %>p & effective weapon = ! campaign aga9/ quack]y4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,april #bg1 #aiab47 ,,antikamnia ,! ,no/rum & ,its ,me?od ( ,exploitation ,our read]s w be int]e/$ to le>n "s ( ! rem>kable prop]ties :i*1 accord+ to ! /atem5ts ( ! manufactur]s1 ?is ,antikamnia possesses4 ,we quote f ! adv]tis+ lit]ature3 ,! well-kn[n n]ve speciali/ 7871 ,dr4 ,h>ley1 9 an int]view publi%$ 9 ! ,london ,daily ,express1 says3 8,i h treat$ m ?an "o ,am]ican = n]v\sness & #8bra9 fag' directly due to _! incessant en]gy4 ,i _h a "y man 9 "h ?is morn+ :o compla9$ ( heada*e #89 ! back ( ! neck4' ,he 0 ?reat5$ ) conge/ion ( ! bra91 & seem$ some:at aggriev$ :5 ,i told him he _h be5 try+ to d too mu*4 ,i also treat$ a "y ,am]ican woman :o1 s9ce h] arrival 9 ,london1 _h app>5tly be5 liv+ on ,antikamnia tablets by ! advice ( h] physician4 ,x 0 ! only ?+1 %e said1 :i* kept h] #8brac$ up' = ! /ra9 ( sight-see+40 7,:y did ! "y woman consult ?is ,dr4 ,h>ley--= ! drug habit87 ,note ! foll[+3 ,= ! sev]e pa9s ( rheumatism1 dysm5orrhea1 neuralgia1 g\t1 sciatica & lumbago1 z well z = ! lightn+ pa9s ( locomotor ataxia1 !re c be no quick] & m la/+ relief obta9$ ?an by ! adm9i/ration ( ,antikamnia & code9e tablets4 ,imag9e an intellig5t physician try+ to treat ! diseases m5tion$ bel[ ) ! v>i\s impot5t means ( ! ph>macopeia & physiological !rapy :5 he might dep5d on ,antikamnia6 ,we quote aga93 ,z a ,pa9 ,reliev]4--,9 heada*e1 cephalalgia1 hemicrania1 migra9e "s o!r words might h be5 ?r[n 9 s z /ill m to emphasize ! heada*e bus9ess1 myalgia1 coryza1 la grippe & its sequelae1 ! lightn+ pa9s ( locomotor ataxia & all pa9s due to irregul> m5/ruation4 ,z an ,anodyne or ,s$ative4--,9 alcoholic delirium1 indige/ion1 c>dialgia1 ga/ralgia1 dyspepsia1 hy/]ia1 insomnia1 inebriety1 c>-sickness1 sea-sickness1 worry & sight-se]'s fatigue4 ,z an ,antipyretic4--,9 typhoid1 int]mitt5t1 pu]p]al & mal>ial fev]s1 bron*itis1 pneumonia1 pleurisy1 & tub]culosis4 ,z an ,anti-,neuralgic4--,9 acute or *ronic neuralgia1 facial neuralgia1 e>a*e1 pa9 ab\t ! tee?1 ang9a pectoris1 neura/h5ia1 palpitation1 pa9s ( locomotor ataxia & sciatica4 ,z an ,anti-,rheumatic4--,9 acute or *ronic rheumatism & g\t1 fev] & pleurodynia4 ,!re is no rem$y s useful & att5d$ ) su* satisfactory results z ,antikamnia tablets 9 ! treatm5t ( melan*olia ) vasomotor di/urbances1 anemic heada*es1 emotional di/ress1 & active delusions ( appreh5sion & di/ru/4 ,!y increase art]ial t5sion & promote dige/ion1 z well z be+ p>ticul>ly s]viceable 9 reliev+ ! p]si/5t heada*e :i* accompanies n]v\sness4 ,9 neura/h5ia1 9 mild hy/]oid affections1 & 9 ! v>i\s neuralgias1 p>ticul>ly ov>ian1 & 9 ! n]v\s tremor s (t5 se5 9 confirm$ drunk>ds1 !y are ( peculi> s]vice4 ,9 ang9a pectoris ?is drug has a b5eficial action2 x relieves ! pa9 & di/ress 9 _m cases1 ev5 :5 amyl nitrite & nitroglyc]9 h fail$ entirely4 ,9 pseudo-ang9a1 frequ5tly obs]v$ 9 hy/]ical wom51 its action is all t c be desir$4 ,pati5ts :o suff] f irritable1 weak1 or palpitat+ he>t1 ne$+ at times a pa9 reliev]1 c take ,antikamnia tablets1 )\t unt[>d aft]-effects1 kn[+ t ! he>t is be+ =tifi$4 ,9 delirium trem5s1 !y relieve :5 !re are great re/lessness1 insomnia1 ! g5]al l[]+ ( ! n]ve p[]4 ,only ! vivid picture ( a crisis 9 locomotor ataxia or ! agony ( a true migra9e1 c impress ! obs]v] ) ! full value ( ?is pa9 reliev]4 ,! foll[+ te/imonials are f physicians3 ,dr4 ,caleb ,lyon1 an old ,bellevue practition]1 9 ref]r+ to antikamnia & code9 tablets1 says3 ,9 my practice !y accompany ! maid f h] virg9 c\* to h] ly+-9 *amb]1 assuag+ ! p]plexities ( maid5hood & eas+ ! trials ( mat]nity ) mo/ gratify+ results4 ,i e>ne/ly hope t ! proprietors ( ?is valuable rem$ial ag5t w keep x up to its pres5t /&>d ( purity & excell5ce4 ,dr4 ,walt] ,m4 ,flem+1 ,a4,m41 ,m4,d41 ,new ,york ,city1 writes3 444 ,) all ! exp]i5ce ( m ?an a qu>t] ( a c5tury1 9 ! treatm5t ( w9t] c\gh1 & all its complications ( l>yngeal1 bron*ial & pulmon>y irritability1 dyspnea1 a/hmatic spasms1 & f9ally :oop+ c\gh--usually ! mo/ p]si/5t & t5aci\s ( all ^! membran\s maladies--,i f9d no "o rem$y m /rongly indicat$1 or :i* yields m prompt & satisfactory results ?an ,antikamnia & h]o9 tablets1 compos$ ( ,antikamnia #e gra9s & h]o9 hydro*loride #a_/ab gra94444 ,result3 a prompt & effici5t expectorant1 at once relax+ ! h>% & rasp+ c\gh1 releas+ ! t5aci\s1 /icky & gelat9\s mucus :i* is soon readily expectorat$1 :ile ! soo?+ influ5ce ( ! ,antikamnia is at once manife/$1 greatly to ! com=t & cont5tm5t ( ! pati5t4 444 ,indep5d5t ( ! fact ( ! direct applicability ( ?is rem$y to ! v>i\s membran\s maladies ( ! lungs1 bron*i1 fauces & nose1 x proves also1 an inv>iable rem$y 9 all febrile cases :]e anodyne is requir$4 ,?is1 toge!r ) its analgesic & antipyretic m]its1 em95tly qualify ?is comb9ation = a responsive ag5t 9 ! treatm5t ( ne>ly all ! num]\s febrile attacks *>act]iz$ by pa91 n]v\sness1 insomnia & _! accompany+ symptoms4 8,antikamnia & ,qu990 ,if !re is any virtue 9 ! p>ticul> comb9ation kn[n z 8,antikamnia10 a physician prescrib+ ! tablets suppos$ to conta9 comb9ations ( 8,antikamnia0 & "s o!r drugs %\ld h "s gu>antee t !y conta9 ^? rem$ies4 ,take1 = example1 ! tablets adv]tis$ & sold z 8,antikamnia & qu9940 ,x might reasonably be suppos$ t ! tablets conta9$ ! comb9ation kn[n z 8,antikamnia02 ?is1 h[ev]1 seems n to be ! case4 ,previ\s analyses1 z publi%$#aje by u1 h %[n t antikamnia conta9s approximately #bj p] c5t4 ( sodium bic>bonate1 yet two *emi/s1 work+ sep>ately1 h be5 unable to f9d ?is +r$i5t 9 ! tablets adv]tis$ & sold z 8,antikamnia & qu9940 ,are we to und]/&1 !re=e1 t ! manufactur]s d n consid] ! bic>bonate ( sodium ( importance 9 _! prep>ation1 ,antikamnia2 or are !y guilty ( misrepres5tation & ( mislead+ physicians 9 omitt+ ?is con/itu5t f _! product ,antikamnia :5 t is comb9$ ) ! bisulphate ( qu998 ,! above /atem5t reg>d+ ! omission ( bic>bonate ( sodium f ! qu99 comb9ation may be v]ifi$ by any physician :o desires to make a few simple *emical te/s--c>bonic acid is n giv5 (f :5 ! tablets are treat$ ) dilute acids1 z w\ld be ! case if sodium bic>bonate 7 pres5t4 ,fur!r1 :ile ! ord9>y ,antikamnia conta9s no con/itu5t n soluble ei!r 9 wat] or 9 *lor(orm1 & :ile qu99 bisulphate is readily soluble 9 wat]1 ! tablets said to conta9 ,antikamnia & qu99 bisulphate1 :5 treat$ successively ) wat] & ) *lor(orm1 leave a residue ( m ?an #ah p] c5t4 #aje ,! ,j\rnal ,a4 ,m4 ,a41 ,june #c1 #aije2 reproduc$ on page #i ( ?is book4 ,"o ( ! *emi/s :o analyz$ ! prep>ation = u1 9 comm5t+ on ?is 9 a lett]1 says3 8,! matt] :i* is insoluble 9 wat]1 alcohol or 9 *lor(orm1 i4 e41 ! sub/ance :i* is nei!r #8,antikamnia' nor qu99 bisulphate1 am\nts to m ?an #ah p] c5t4 9 #8,antikamnia & qu99 bisulphate tablets4' ,! tablets weigh close to five gra9s & are said to conta9 #b4e gra9s ea* ( ,antikamnia & qu99 bisulphate4 ,h[ is ?is possible :5 ea* tablet conta9s almo/ "o gra9 ( =eign sub/ance 7*iefly />*780 ,fur!r comm5t is sup]flu\s4 ,we h pres5t$ facts to our read]s & leave1 !m to draw _! own conclusions4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,july #a1 #aije47 ,add+ ,insult to ,injury ,:5 ! ,c\ncil on ,ph>macy & ,*emi/ry began its "w ( indep5d5t & sci5tific inve/igation ( propriet>y prep>ations1 "s ( ! que/ions ask$ 73 8,:at gu>antee has ! m$ical pr(ession t ! =mulas ( ^! propriet>y m$ic9es are n *ang$ at ! w ( ! manufactur]s8 ,h[ c ! physician :o confid+ly prescribes !m = 8 pati5ts "k t ! prep>ation :i* he ord]s to-day is ! same z t :i* 0 furni%$ him la/ ye>1 or :i* may be giv5 him next ye>1 "u ! same "n80 ,at once a wail1 z ( injur$ innoc5ce1 w5t up f c\ntless v5d]s ( propriet>y m$ic9es1 :o repli$ ) "o voice3 8,! honor & reputation ( ! proprietors & manufactur]s is suffici5t gu>antee ( ! /ability & p]man5ce ( ^! prep>ations40 ,s vehem5t 7 _! prote/ations & s well simulat$ 7 _! decl>ations ( ,pecksniffian virtue t _m physicians 7 deceiv$ !reby4 ,_m m$ical j\rnals 7^: views 71 p]haps1 slightly bias$ by ! consid]ation ( fat adv]tis+ contracts7 also 7 app>5tly conv9c$4 ,b ! fact 0 ov]look$ t gu>antees bas$ on honor are ( value only 9 proportion to ! am\nt & quality ( honor possess$ by ! gu>antors4 ,! enactm5t ( ! national ,food & ,drugs ,act is br++ _m ?+s to light4 ,"s ( !m are int]e/+1 "s w\ld be amus+ 7 !y n s utt]ly despicable4 ,among o!r ?+s1 x has furni%$ a demon/ration ( ! value ( ! 8honorable assurances0 ( no/rum v5d]s4 ,! no/rum ,antikamnia has po9t$ out _m a moral 9 ! campaign 9 ! la/ two ye>s4 ,x 0 h>dly to be hop$ t x w\ld delib]ately furni% a demon/ration ( ! utt] lack ( hone/y on ! "p ( a c]ta9 class ( propriet>y manufactur]s4 ,yet1 rely+ app>5tly on ! ignorance ( ! public & ! long-cont9u$ le?>gy ( ! m$ical pr(ession1 its promot]s h1 9 ! la/ few weeks1 unwitt+ly convict$ & /ultifi$ !mselves4 ,:5 ! pure food law w5t into effect1 ! proprietors ( ?is mixture f\nd !mselves 9 a sad dilemma2 if !y label$ _! mixture 9 accordance ) ! provisions ( ! law !y w\ld h to admit t x conta9$ acetanilid & t ! *>ges aga9/ !m 7 true4 ,fail+ to comply ) ! law1 !y mu/ g out ( bus9ess4 ,! latt] alt]native 0 n to be ?\ght (4 ,! pr(its ga9$ by sell+1 ) ! aid ( c>eless or ignorant physicians1 a five- or t5-c5t mixture = #a 7 too great to be surr5d]$ )\t a /ruggle4 ,! same brilliant intellect1 p]haps1 t fir/ saw ! comm]cial possibilities 9 ! bus9ess said3 8,*ange ! =mula4 ,ph5acet9 is ab\t z *eap z acetanilid2 ! pat5t has j expir$ & consequ5tly we c get x at a l[ price4 ,let u sub/itute ph5acet9 = acetanilid40 ,z a result ! pr(ession is treat$ to an edify+ exhibition ( virtue triumphant1 a wolf s completely cov]$ by ! h>mless coat ( a %eep t he flatt]s himself t 8 wolfi% nature is completely conceal$4 ,no long] are skulls & skeletons s5t out 9 cal5d> =m z gr9n+ advance ag5ts to be display$ 9 e doctor's (fice1 b in/ead a beautiful dome/ic sc5e1 %[+ a convalesc5t *ild ne/l+ 9 ! arms ( its "m4 ,! famili> 8,,ak10 h[ev]1 z usual1 is 9 ! l[] "r-h& corn]4 ,& :at a *ange 9 labels6 ,no long] is ,antikamnia a *emical entity1 b ! label n[ op5ly b +5u\sly decl>es t 8,antikamnia tablets 9 ?is orig9al package conta9 #cej gra9s ( acetph5etid91 ,u4 ,s4 ,p41 p] ounce4 ,gu>ante$ "u ! ,food & ,drugs ,act1 ,june #cj1 #aijf4 ,s]ial ,no4 #aj40 ,:ile1 bel[1 z an entirely unnecess>y display ( con=mity to ! ,pure ,food ,act1 appe>s ?is /atem5t3 ,! ,antikamnia tablets 9 ?is orig9al ounce package conta9 no acetanilid1 antifebr91 antipyr91 alcohol1 morph91 opium1 code91 h]o91 coca91 alpha- or beta-euca91 ars5ic1 /ry*n91 *lor(orm1 cannabis indica or *loral hydrate4 ,truly1 ,satan is appe>+ z an angel ( light4 ,:at a gratification x is to ! long exploit$ pr(ession to "k t ,antikamnia conta9s no alcohol1 no *lor(orm1 no cannabis indica1 no *loral hydrate4 ,h[ un=tunate t ?is spontane\s display ( confid5ce is n c>ri$ f> en\gh to in=m ! pr(ession ( ! +r$i5ts1 aside f ph5acet91 conta9$ 9 ! mixture6 ,! label is an admission t ! no/rum does n conta9 :at x 0 nev] suppos$ to conta91 ) ! exception ( acetanilid1 & is directly an attempt to conceal ! real cont5ts4 ,! proprietors "k t ! de> public1 ^: 8pa9s1 heada*es1 neuralgias1 wom5's a*es & ills1 grippal neuroses1 n]v\sness1 insomnia1 rheumatism1 lightn+ pa9s ( locomotor ataxia1 sciatica1 etc410 !y are long+ to assuage1 w n "k t acetph5etid9 is ! (ficial designation = :at is popul>ly kn[n z ph5acet91 & t ?is dang]\s product is f\nd 9 ! new mixture 9 ! proportion ( approximately #d gra9s to a #e-;gra9 tablet4 ,evid5tly !y also presume consid]ably on ! ignorance ( our pr(ession1 or :y %\ld !y make ! braz5 /atem5t t f\r gra9s ( ph5acet9 is ! 8mo/ reliable rem$y0 = ! long li/ ( diseases enum]at$ on _! adv]tis+ cal5d>8 ,illu/ration3 ,a r$uc$ reproduction ( a full-page ,antikamnia adv]tisem5t appe>+ 9 ! ,new ,york ,_w ,almanac1 #aiaa4 ,:5 ! =mula = :i* su* wond]ful virtues 7 claim$ 0 sudd5ly ?r[n ov]bo>d1 0 ! m$ical pr(ession1 :i* by its %ort-sight$ patronage _h built up ?is bus9ess1 notifi$ 9 any way ( ! *ange8 ,se>* ! new adv]tis+ matt] ( ?is no/rum f beg9n+ to end & y w n f9d "o ^w to %[ t 8,! ,antikamnia tablets 9 ?is orig9al ounce package0 diff] 9 ! slighte/ p>ticul> f ^? sold to ! pr(ession & ! public = ye>s pa/4 ,?is be+ true 7& ! /atem5ts ( ! promot]s !mselves are our au?ority = x71 :at rema9s ( ! prat+s ( 8honor0 & ! 8gu>antee ( ! manufactur]s08 ,has a physician no "r to "k :5 a *ange is made 9 ! =mula ( a prep>ation :i* he has be5 prescrib+ = ye>s8 ,:at assurance has ! pr(ession t1 at any mom5t1 a *eap] or m dang]\s drug may n be sub/itut$ = 8acetph5etid90 if !reby ! law c be evad$ or ! pr(its ( ! delectable bus9ess enhanc$8 ,h[ c any consci5ti\s physician prescribe1 = ^? :o confide _! lives to 8 c>e1 a prep>ation ! /ability ( ! =mula ( :i* mu/ dep5d absolutely on its own]'s :im8 ,h[ c a physician ) ! slighte/ s5se ( responsibility to 8 pati5ts all[ 8 (fice to be us$ z a free adv]tis+ bureau = a prep>ation manife/ly f\nd$ & develop$ on deceit & misrepres5tation8 ,h[ c any m$ical j\rnal1 except ^? av[$ly & unblu%+ly seek+ to aid ! no/rum mak] to exploit ! pr(ession1 ^: int]e/s !y claim to s]ve1 cont9ue to c>ry ! deceptive & mislead+ adv]tisem5t ( a twice expos$ fraud8 ,h[ c any physician ) a p>ticle ( self-respect or manhood cont9ue to support1 by subscription or contribution1 any m$ical j\rnal :i*1 by accept+ su* adv]tis+1 allies itself ) ! army ( deceit & *ican]y8--7,ab/ract$ f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #bf1 #aijg47 ,/ill ,fur!r ,duplicity ,:5 ! ,food & ,drugs ,act w5t into effect ! manufactur]s ( ?is prep>ation1 in/ead ( cont9u+ to put out ! same mixture z !y _h be5 do+ radically *ang$ ! composition by sub/itut+ acetph5etid9 7ph5acet97 = acetanilid4 ,by do+ ?is ! company avoid$ ! disagreeable necessity = ackn[l$g+ on ! label t ! no/rum conta9$ acetanilid1 z 0 %[n by ! analysis publi%$ 9 ,! ,j\rnal1 ,june #c1 #aije4 ,9 addition to /at+ t ! package ( ,antikamnia conta9$ acetph5etid91 ! company also /at$ t x conta9$ no 8acetanilid1 antifebr91 antipyr91 alcohol1 morph91 opium1 code91 h]o91 coca91 /ry*n91 *lor(orm1 cannabis indica1 or *loral hydrate40 ,kn[+ t ! no/rum 0 be+ adv]tis$ 9 ,great ,brita9 & ,canada z well z 9 ! ,unit$ ,/ates1 ,! ,j\rnal obta9$ "s ,antikamnia f ,london1 & x 0 analyz$ 9 ! ,association's laboratory4 ,z 0 suspect$1 ! analysis %[$ t ,antikamnia z sold abroad has ! same composition n[ z x _h 9 ! ,unit$ ,/ates be=e ! ,food & ,drugs ,act w5t into =ce1 viz43 ,acetanilid1 #fg4ge p] c5t42 caffe91 #d4hh p] c5t41 & citric acid & sodium bic>bonate1 by diff]5ce1 #be4cf p] c5t4 ,?is corresponds ) ! analysis previ\sly made & publi%$ 9 ,! ,j\rnal1 ,june #c1 #aije4 ,! ,antikamnia on ! m>ket 9 ?is c\ntry 0 also analyz$ & x 0 f\nd to conta93 acetph5etid9 7ph5acet971 #gb4je p] c5t42 caffe91 #ac4ie p] c5t42 citric acid & sodium bic>bonate1 #ad p] c5t4 ,! prep>ation sold z 8,antikamnia & ,qu990 0 also analyz$1 & x 0 f\nd t />* _h be5 sub/itut$ = ! bic>bonate ( sodium :i* is f\nd 9 ! ,antikamnia itself4 ,! details ( ! analyses are giv5 ) ! foll[+ comm5ts3 8,! above are brief /atem5ts ( bald facts4 ,two ( ^! %\ld be emphasiz$3 7#a7 ,:5 ! ,food & ,drugs ,act w5t into =ce1 ,janu>y1 #aijg1 ! manufactur]s ( ,antikamnia1 r ?an ackn[l$ge ! tru? ( ! pa/--we c imag9e no o!r reason--mat]ially & radically *ang$ ! composition ( _! prep>ation1 & did ?is )\t notify+ ! m$ical pr(ession or intimat+ 9 any way1 s f> z we c le>n1 t su* a *ange _h be5 made4 ,we h no d\bt !y believ$ !y _h a "r to d z !y pleas$ ) _! own2 t x 0 nobody's bus9ess b !irs :at !y did ) _! own prep>ation1 or h[ !y *ang$ x4 ,z !y nev] _h told physicians :at x conta9$1 !re 0 no reason :y !y %\ld d s n[4 ,?is is logical & we _c blame ! manufactur]s s long z ! m$ical pr(ession is will+ to be humbugg$4 7#b7 ,= ! same reason1 we presume1 !y claim t !y h a "r to cont9ue to use acetanilid 9 ! product = ! =eign m>ket4 ,! ,food & ,drugs ,act applies only to ! ,unit$ ,/ates1 ( c\rse1 & acetanilid be+ *eap]1 :y n use x8 ,:at is ! diff]5ce if "o is m dang]\s ?an ! o!r8 ,! fact t ! ,antikamnia sold abroad diff]s f t sold 9 ?is c\ntry "s may say is ( no special int]e/ to u4 ,/ill ?is fact is wor? not+3 ,! dose ( acetph5etid9--ph5acet9--7#g-a_/b gra9s7 is ne>ly d\ble t ( acetanilid 7#d gra9s73 "o becom+ accu/om$ to a c]ta9 dosage ( ! no/rum z sold 9 ?is c\ntry might1 :ile abroad1 unwitt+ly be l$ to take a d\ble dose ( acetanilid4--7,ab/ract$ f ,! ,j\rnal ,a4 ,m4 ,a41 ,feb4 #h1 #aijh47 ,samples1 ,=m ,lett]s & 8,prescriptions0 ,s5t to ! ,laity ,to ! ,editor3--,! enclos$ 8lit]ature0 is be+ s5t broadca/ to ! laity by ! ,antikamnia p & /ill a great _m ( ! physicians ?r\gh\t ! c\ntry are prescrib+ ! prep>ation ?us adv]tis$4 ,w ! "t ev] come :5 ! m$ical frat]nity w awak5 to ! fact t x has be5 humbugg$ by a great _m manufactur+ conc]ns8 ,i c]ta9ly hope s4 ,j4 ,w4 ,du,val1 ,m4,d41 ,wi*ita ,falls1 ,texas4 ,comm5t3--,! 8lit]ature0 ref]r$ to by our correspond5t consi/s ( a =m lett] & a small pamphlet4 ,! lett] 0 simil> to ! "o reproduc$ h]e)4 ,illu/ration ,! pamphlet accompany+ ! lett] is entitl$ 8,practical ,prescriptions10 & conta9s a li/ ( diseases & morbid /ates arrang$ alphabetically f 8,alcoholism10 8,a/hma0 & 8,backa*e10 to 8,w9d10 8,wom5's ,pa9s0 & 8,worry40 ,= ! "o hundr$ & tw5ty-two conditions li/$1 8,antikamnia10 8,antikamnia & ,code90 or 8,laxative ,antikamnia & ,qu990 are prescrib$1 demon/rat+ t ! 8prescriptions0 are m 8practical0 ?an sci5tific4 ,9 _m respects ! me?ods ( ! proprietors ( 8heada*e p[d]s0 & 8anti-pa9 pills0 are less (f5sive to "o's s5se ( pr(essional dec5cy ?an ! c\rse pursu$ by ! ,antikamnia p4 ,! =m] h at lea/ nev] recomm5d$ _! products z 8e?ical propriet>ies02 !y h n us$ m$ical m5 z _! unpaid ag5ts2 ! claims made = _! products h be5 no m exagg]at$2 & !y h n f\nd x necess>y1 f ! requirem5ts ( ! ,food & ,drugs ,act1 to sub/itute acetph5etid9 = acetanilid to avoid giv+ ! lie to _! =m] claims4 ,z to ! qu]y prop\nd$ by our correspond5t3 ,we are optimi/ic en\gh to believe t ! "t he longs = is already "h4 ,! fact t ! proprietors ( no/rums ( ! ,antikamnia type are f9d+ x necess>y to adv]tise to ! laity is1 9 itself1 evid5ce ( ! dim9i%+ dem& = su* products on ! "p ( ! m$ical pr(ession4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,april #ah1 #aijh47 ,antikamnia 9 ,am]ica & ,great ,brita9 ,! foll[+ lett] f ! ,antikamnia ,*emical ,company to ,! ,j\rnal 0 receiv$ ab\t ,augu/ #a1 #aiab3 8,y h at v>i\s times repres5t$ 9 y\r ,j\rnal t ! ,antikamnia sold 9 =eign c\ntries1 p>ticul>ly 9 ,great ,brita91 has a diff]5t =mula f ! ,antikamnia sold 9 ! ,unit$ ,/ates1 & y h also publi%$ alleg$ =mulas ( ea* to %[ :]e9 !y are suppos$ to diff]4 8,we h]eby respectfully notify y t ! ,antikamnia =mula is ! same = all c\ntries1 & ! publication ( any /atem5ts to ! effect t ! =mula ( ,antikamnia is diff]5t 9 ,great ,brita91 or any o!r =eign c\ntry1 f t sold 9 ! ,unit$ ,/ates is a libel1 & w be prosecut$ z su*40 ,on ! receipt ( ?is a lett] 0 writt5 to a correspond5t 9 ,london reque/+ him to pur*ase 9 ! op5 m>ket a package ( ,antikamnia4 ,?is 0 done & ! orig9al seal$ package rea*$ ! ,association's laboratory a few days ago4 ,c>eful analysis ( ?is specim5 %[s x to conta9 acetanilid b no acetph5etid91 :ile ! ,antikamnia sold 9 ! ,unit$ ,/ates conta9s acetph5etid9 b no acetanilid4 ,! company's prote/ to ! contr>y not)/&+1 ! =mula ( "s ,antikamnia1 at lea/1 is /ill diff]5t 9 ,great ,brita9 f t sold 9 ! ,unit$ ,/ates4 ,x is possible1 ( c\rse1 t "s "t 9 ! future ! composition ( e package ( ?is no/rum on sale 9 ! ,unit$ ,k+dom w be simil> to t ( e package sold 9 ! ,unit$ ,/ates4 ,x is ev5 possible t 8,antikamnia ,qu990 tablets w--or d--actually consi/ ( qu99 & ! mixture call$ ,antikamnia--al?\gh1 z ,! ,j\rnal has %[n1 ?is has n be5 ! case 9 ! pa/4 ,s9ce ! pat5t expir$ on acetph5etid91 ?is drug has become s *eap--x c be b\ght at :olesale = less ?an #f c5ts an ounce--t1 comm]cially x mu/ make v little diff]5ce :e!r acetanilid or acetph5etid9 is us$ 9 ! manufacture ( ,antikamnia4 ,b ! "q arises3 ,h our ,briti% confrres be5 notifi$ ( ! *ange 9 =mula8 ,a c>eful /udy ( ! ,antikamnia adv]tisem5ts 9 ,engli% m$ical j\rnals %[s t ! ,briti% m$ical pr(ession has be5 giv5 no m consid]ation by ?is conc]n ?an 0 ! ,am]ican m$ical pr(ession :5 ! *ange 9 composition 0 made on ?is side4 ,b !n :y %\ld x be8 ,physicians1 ,briti% or ,am]ican1 :o are addict$ to ! prescrib+ ( secret propriet>ies su* z ,antikamnia h little ne$ ( =mulas--8,!irs n to reason :y60 ,! m$ical pr(ession on bo? sides ( ! ,atlantic has nev] kn[n ! exact composition ( ,antikamnia & does n "k x n[4 ,physicians :o call = prep>ations ( ! ,antikamnia type are prescrib+ names1 n drugs4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,oct4 #bf1 #aiab47 ,aga91 ,antikamnia ,illu/ration3 ,reproductions ( portions ( pages 9 ! booklets s5t out by ! ,antikamnia ,*emical ,company to physicians 7on ! "r71 & laym5 7on ! left71 respectively4 ,^? :o d n realize ! "* ( ! ,antikamnia conc]n naturally imag9e ! quotation "h giv5 f ,! ,j\rnal is a comp>atively rec5t "o4 ,notice t no dates are giv54 ,z a matt] ( fact1 x is tw5ty-two ye>s old4 ,dr4 ,mc,intyre1 :o wrote x1 has be5 dead elev5 ye>s4 ,9 season & out ( season ,! ,j\rnal has expos$ ! ,antikamnia fraud until x w\ld seem t its read]s w\ld become we>y ( ! v "n4 ,!re is no?+ new to say ab\t ?is dang]\s /uff1 & yet ! numb] ( inquiries indicates t ?\s&s ( ,! ,j\rnal's read]s d n "k ( ! previ\s exposures4 ,m ?an fifte5 ye>s ago ,! ,j\rnal ceas$ c>ry+ ! ,antikamnia adv]tisem5t2 m ?an t5 ye>s ago x notifi$ its read]s t ! no/rum 0 be+ adv]tis$ to ! public by means ( circul> lett]s2 m ?an six ye>s ago x prov$ t1 :5 ! ,food & ,drugs ,act w5t into effect1 acetph5etid9 _h be5 sub/itut$ = acetanilid 9 ,antikamnia evid5tly 9 ord] t ! pres5ce ( ! old] drug1 ( ^: dang]s ! public _h be5 made aw>e might n h to be admitt$2 m ?an five ye>s ago ,! ,j\rnal %[$ t ! ,antikamnia sold 9 ! ,briti% ,isles /ill conta9$ acetanilid1 & z late z la/ ,octob] x v]ifi$ ?is /atem5t al?\gh ?reat5$ ) prosecution = libel by ! ,antikamnia ,*emical ,company4 ,yet1 9 spite ( all ^! exposures1 n a week passes t we d n receive "o or m lett]s call+ att5tion to ! ,antikamnia fraud4 ,mo/ ( ^! lett]s deal ) "o1 or m1 ( ?ree po9ts3 fir/1 ! fact t ! /uff is be+ adv]tis$ to ! public by means ( circul> lett]s & t sample 8ve/-pocket boxes0 ( ?is dang]\s drug are be+ s5t ?r\gh ! mail to laym52 second1 t ,antikamnia is be+ adv]tis$ 9 newspap]s1 &1 ?ird1 t 9 ! booklets s5t out by ! ,antikamnia ,*emical ,company bo? to ! m$ical pr(ession & to ! public1 a p>agraph is quot$ f an article by ,dr4 ,john ,h4 ,mc,intyre t appe>$ 9 ,! ,j\rnal4 ,illu/ration3 ,photographic reproductions ( two typical ,antikamnia adv]tisem5ts n[ appe>+ 9 newspap]s all ov] ! c\ntry4 ,^! tablets are adv]tis$ 9 v>i\s newspap]s z be+ 8safe0 & nei!r 8depressant0 nor 8habit-=m+0--?ree sep>ate & di/9ct falsehoods4 ,! fir/ two po9ts h already be5 discuss$ s frequ5tly t x seems h>dly wor? :ile to take !m up aga9 9 detail1 ?\gh x might be said t ! m$ical pr(ession has at la/ become s famili> ) ?is widespread humbug t ! ,antikamnia ,*emical ,company has f9ally gone ov] body & s\l to ! newspap]s4 ,s f> z we c le>n only ?ree publications pr(ess+ to be m$ical j\rnals /ill c>ry ! ,antikamnia adv]tisem5t4 ,^! ?ree are3 ,s\!rn ,practition] ,!rapeutic ,record ,pacific ,m$ical ,j\rnal ,z is usual 9 su* cases1 ! ,briti% m$ical j\rnals are n s p>ticul>1 & we /ill f9d ,antikamnia adv]tis$ 93 ,m$ical ,press & ,circul> ,glasg[ ,m$ical ,j\rnal ,j\rnal ,tropical ,m$ic9e & ,hygi5e ,dubl9 ,j\rnal ,m$ical ,sci5ce ,lancet ,canada ,lancet ,practition] ,! reproduction ( ! ,mc,intyre quotation is evid5tly adopt$ by ! ,antikamnia conc]n z a means ( 8play+ ev50 ) ,! ,j\rnal = ! unpleasant ?+s x has said ab\t x4 ,9 quot+ ,dr4 ,mc,intyre1 ! ,antikamnia ,*emical ,company c>efully avoids giv+ ! date on :i* ! article appe>$4 ,z a matt] ( fact1 ! article 0 pr9t$ 9 ,! ,j\rnal ov] tw5ty ye>s ago 7,july #d1 #ahia71 & ,dr4 ,mc,intyre himself has be5 dead = elev5 ye>s4 ,presumably1 h[ev]1 ! ,antikamnia ,*emical ,company w cont9ue to mislead1 ei!r directly or by inf]5ce1 until ! end ( ! *apt]4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,april #ab1 #aiac47 ,,anusol ,,suppositories 8,9 ,hemorrhoids & all ,inflammatory ,rectal ,diseases1 let y\r fir/ ?\ght ,cont9ue to be ,anusol ,hemorrhoidal ,suppositories2 !y h ,e>n$ y\r la/+ ,confid5ce40 ,?us speaks an attractive fold] rec5tly s5t to physicians4 ,) a prodigal use ( sup]latives1 ! m$ical pr(ession is told t ^! suppositories h = ye>s 8ma9ta9$ _! ,_w-,wide ,reputation0 z ! 8,mo/ ,effective1 ! ,safe/ 444 ! ,mo/ ,economical & 444 ! ,mo/ ,cr$it-,br++ ( all ,topical ,rectal ,rem$ies40 ,! %ort memory ( ! public is notori\s2 f ! po9t ( view ( ! propriet>y exploit]1 ! %ort memory ( ! m$ical pr(ession mu/ be equally well kn[n4 ,h[1 o!rwise1 w\ld a firm try to make physicians believe t a product _h 8e>n$0 _! 8la/+ confid5ce0 :5 ! result ( an exam9ation by ! ,association's *emi/s1 publi%$ 9 ,! ,j\rnal1#ajf _h %[n t ,anusol ,hemorrhoidal ,suppositories conta9$ practically no 8anusol40 ,moreov]1 z ! ,association's f9d+s 7 a practical v]ification ( ! f9d+s ( a =eign *emi/ :o also _h fail$ to f9d any 8anusol0 9 ,anusol ,suppositories1 x is n q cle> :at is meant by ! t]m 8_w-wide reputation40 ,incid5tally1 ! obs]vant physician w notice t ! li/ ( ! +r$i5ts giv5 on ! ,anusol ,suppositories labels ( #aiac diff] f ^? ( ! v9tage ( f\r ye>s ago4 ,! label ( ! old boxes gave ! +r$i5ts ?us3 ,bismu?4 iodo-resorc9sulfon 7,anusol71 ,z9c oxydat4 pur41 ,balsam ,p]uv41 ,ol4 cacao1 ,ungu5t c]eum4 #ajf ,oct4 #b1 #aiji2 see p4 #bbg ( ?is volume4 ,on ! late/ label1 h[ev]1 we f9d ^! +r$i5ts giv53 8,bismu? oxyiodid & resorc9sulphonate ) ,z9c oxid & ,balsam ,p]u1 incorporat$ 9 suitable base40 ,:at w ! =mula be f\r ye>s h5ce8--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,oct4 #aa1 #aiac47 ,,anusol ,,suppositories ,to ! ,editor3--,9 ! 8,propag&a = ,re=m0 dep>tm5t ( ! ,octob] #aa issue ( ,! ,j\rnal1 y publi%$ a %ort notice on ,anusol ,suppositories4 ,we desire to correct ! impression :i* y\r read]s may h receiv$1 viz43 t !re is any actual diff]5ce betwe5 ,anusol ,suppositories ( ! pres5t & ,anusol ,suppositories ( ! pa/4 ,we wi%1 !re=e1 to /ate t ! composition ( ,anusol ,suppositories has n be5 *ang$2 ! only modification t we h made is a revision ( ! label to ! effect t ! active m$ic9al +r$i5t ( ! prep>ation is a mixture ( bismu? oxyiodid & bismu? resorc9sulphonate 9 place ( bismu? iodoresorc9-sulphonate4 ,! latt] 0 orig9ally claim$ by ! manufactur]s1 discov]$ to be d\btful by an inve/igation 9 ! laboratory ( ! ,am]ican ,m$ical ,association1 z well z by "o on ! "p ( a =eign *emi/1 & f9ally disprov$ to our satisfaction by an indep5d5t inve/igation on our "p4 ,we feel t ! rem>k 8,:at w ! =mula be f\r ye>s h5ce80 w c>ry ! impression to y\r read]s t ! composition has frequ5tly be5 *ang$ & is likely to be *ang$ aga91 & x is = ?is reason t we reque/ ! above correction & an assurance to ! contr>y4 ,! /atem5t 9 ! note t 8,anusol ,suppositories h be5 prov$ to conta9 no ,anusol0 is also likely to create an entirely errone\s impression4 ,we dropp$ ! use ( ! ^w 8anusol10 z designat+ a def9ite *emical sub/ance m ?an two ye>s ago1 & *ang$ all our propag&a matt] accord+ly4 ,s*]+ ,glatz4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #ca1 #aiad47 ,,aspiro-,,li?9e ,aspiro-li?9e is ano!r comp>atively new example ( ! cu/om ( propriet>y manufactur]s 9 putt+ =w>d old drugs "u a new "n & ) !m bidd+ = ! favor ( physicians4 ,an inquiry has be5 receiv$ conc]n+ ?is mixture4 ,x is prep>$ by ,mc,kesson ,robb9s & is said to conta9 9 ea* tablet #e gra9s ( acetysalicylic acid 7aspir97 & #b-a_/b gra9s ( acid citro-t>trate ( li?ium4 ,x is recomm5d$ = all ! purposes = :i* acetysalicylic acid is commonly us$1 & on acc\nt ( ! li?ium add$ is claim$ to h mu* great] virtues ?an ei!r ( ^! drugs alone or ( bo? comb9$4 ,we _h hop$ t ! "t _h pass$ = reputable h\ses to employ su* "t-worn me?ods1 b probably !y w n /op s long z physicians enc\rage !m by cont9u+ to use su* prep>ations4 ,acetysalicylic acid is a good drug1 ^: value is pretty well kn[n4 ,x is fur!r kn[n t li?ium salts d n possess any great m$ic9al virtue4 ,j :at acid citro-t>trate ( li?ium may be is h>d to tell1 = *emi/ries d n recognize su* a sub/ance4 ,! "n presumably is int5d$ to hide ! real nature ( ! prep>ation4 ,b if !re be any advantage 9 comb9+ li?ium salts ) acetysalicylic acid 9 a prescription1 x is a simple proposition & requires no great skill1 ei!r on ! "p ( ! physician :o writes ! prescription or on ! "p ( ! druggi/ :o puts x up1 & su* mixtures z aspiro-li?9e1 ) ! exagg]at$ claims made = !m1 %\ld be avoid$ 9 ! physician's prescrib+4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,may #bh1 #aiaj47 ,,bell-,,ans 7,,pa-,,pay-,,ans1 ,,bell7,,z ,ano!r 8,pat5t ,m$ic9e0 ,foi/$ on ! ,public ,?r\gh ! ,m$ical ,pr(ession ,,z ,see also report on ,papayans ,bell1 p4 #aea4 ,) su* no/rums z ,antikamnia & ,res9ol fre% 9 m9d z flagrant examples ( 8pat5t m$ic9es0 introduc$ to ! public ?r\gh ! m$ical pr(ession1 :at foll[s reg>d+ ,bell-ans1 or1 z x is bett] rememb]$ by physicians1 ,pa-pay-ans 7,bell7 w take on an add$ int]e/4 ,briefly1 ,bell-ans is ! new "n ( a tablet t1 accord+ to *emi/s' reports1 is ess5tially *>coal1 bak+ soda & g+]1 flavor$ ) oil ( w9t]gre54 ,its sell+ po9t1 9 ! pa/ at lea/1 has be5 ! alleg$ pres5ce ( papa94 ,?is drug1 ,bell ,co4 allege1 is pres5t 9 _! tablets & !y claim is 8! dige/ive pr9ciple obta9$ by our own exclusive process f ! fruit ( ,c>ica papaya40 ,z long ago z #aiji1 ! ,c\ncil on ,ph>macy & ,*emi/ry attempt$ to f9d papa9 pres5t 9 :at 0 !n call$ ,pa-pay-ans 7,bell7 & to det]m9e ! dige/ive p[] ( ! tablets b ) negative results4 ,! ef=ts ( o!r *emi/s 7 equally unavail+4 ,9 ,janu>y1 #aiad1 ,bell & ,company *ang$ ! "n ( ! product 8,pa-pay-ans 7,bell70 to 8,bell-ans40 ,z ,! ,j\rnal rem>k$ soon aft]1 x seem$ probable t1 z ! "n ( a no/rum ( ?is k9d is ! manufactur]'s mo/ valuable asset1 ! "n 0 h>dly *ang$1 z 0 alleg$1 = purely euphoni\s reasons4 ,x seem$ m likely t z analyses _h indicat$ !re 0 n1 & probably nev] _h be51 any appreciable am\nt ( papa9 9 ! product1 ! *ange ( "n might be due to ! fe> t "s day ! mislead+ "n might br+ ! prep>ation 9 conflict ) ! f$]al ,food & ,drugs ,act4 ,= ye>s physicians h realiz$ t ! me?ods ( exploitation ( ,pa-pay-ans 7,bell7 h be5 su* z to make ! m$ical pr(ession a va/ free adv]tis+ ag5cy = ! no/rum4 ,s f> z we "k ,pa-pay-ans 7,bell7 has nev] be5 adv]tis$ 9 lay j\rnals--newspap]s1 etc4 ,c]ta9 m$ical j\rnals1 h[ev]1 h1 = a long "t1 c>ri$ ! adv]tisem5ts ( ,pa-pay-ans 7,bell7--& lat] ( ,bell-ans--:ile ,bell ,co4 has be5 lavi% 9 its di/ribution ( free samples1 blott]s & o!r adv]tis+ p>aph]nalia direct to ! m$ical pr(ession4 ,illu/ration3 ,m9iature facsimile ( a lett] receiv$ by a layman4 ,x 0 accompani$ by a small box ( ,bell-ans4 ,two po9ts are wor? not+3 8444 "o hundr$ ?\s& physicians are n[ prescrib+ x02 8any druggi/ w tell y0 t x is p]fectly h>mless6 ,n[ x seems ,bell & ,company are go+ direct to ! public by means ( ve/-pocket samples & lett]s4 ,! lett]1 a m9iature facsimile ( :i* we reproduce1 is "o address$ to laym5 & accompanies a ve/-pocket box ( ! no/rum4 ,"h are "s ( ! ?+s t ,bell & ,company claim ,bell-ans w d3 8,x removes flatul5ce1 v]tigo1 weakness & o!r symptoms ( indige/ion quickly & pleasantly40 8,x relieves vomit+ 9 pregnancy1 alcoholism1 seasickness & *ol]a morbus44440 8,to promote appetite1 dige/ion & ! elim9ation ( toxic & wa/e mat]ial prescribe ! ,bell-ans44440 8444 prev5t eruptions1 nausea1 v]tigo1 pa91 etc44440 8444 remove di/5tion1 pa91 weakness1 depression1 etc44440 8,!re is no d]angem5t ( ! dige/ive organs ^u :i* ! prop] dose ( ,bell-ans 7,pa-pay-ans1 ,bell7 w n act quickly1 pleasantly & favorably44440 ,!re is no physician liv+ :o really believes su* claims z ^!6 ,yet on ! m$ical pr(ession re/s ! responsibility = ! exploitation ( ?is no/rum4 ,^? m$ical j\rnals :i* accept adv]tisem5ts = ?+s ( ?is k9d are n s mu* to blame z ^? physicians :o unprote/+ly tol]ate ! j\rnals t d s4 ,privately own$ m$ical j\rnals are publi%$1 usually1 z a comm]cial proposition2 !y reflect1 to a great] or less ext5t1 ! attitude ( _! read]s1 subscrib]s & contributors4 ,!re are at lea/ ?ree m$ical j\rnals :i* c>ry ! adv]tisem5ts ( ,bell-ans4 ,!y are ! ,new ,york ,m$ical ,j\rnal1 ! ,int]national ,j\rnal ( ,surg]y & ! ,massa*usetts ,m$ical ,j\rnal4 ,bell-ans 7,pa-pay-ans1 ,bell7 possesses ! virtues--& !y are few--& ! limitations--& ^! are _m--inh]5t to a mixture ( bic>bonate ( soda1 g+] & *>coal4 ,any druggi/ c\ld put up j z good a rem$y1 & any physician c\ld write a prescription = a bett] "o 9 ^? cases 9 :i* he might ?9k x indicat$4 ,! :ole secret ( ! comm]cial success ( ,bell-ans lies 9 ! my/]y ( its composition & ! fraudul5ce ( ! claims t h be5 made = x4 ,! same tablets put out "u a non-propriet>y "n1 z an op5 =mula & ) claims t 7 reasonable & true1 w\ld h _h practically no sale4 ,! comm]cial success ( ,bell-ans is a monum5t ^: f\ndation re/s equally on ! unscrupul\sness ( ! manufactur] & on ! gullibility ( a le>n$ pr(ession4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #af1 #aiae47 ,,biosol ,dr4 ,a4 ,n4 ,lak91 ,/ate ,l9e1 ,ind41 writes3 8,k9dly advise me conc]n+ ,biosol4 ,i am s5d+ y h]e) a pamphlet describ+ ?is product4 ,on ! la/ page note cl9ical report f ,dr4 ,bu*man ( ! ,indiana ,m$ical ,association & presid5t ( ! ,dep>tm5t ( ,public ,heal?1 ,=t ,wayne1 ,ind40 ,h4 ,hille1 once ( ,heidelb]g1 n[ ( ,oak ,p>k1 ,ill41 hav+ rea*$ ! conclusion t m9]al />vation is ! cause ( all diseases1 devot$ 8 tal5ts to f9d+ a rem$y4 ,he claims to h f\nd x & calls x 8,biosol40 ,he publi%$ 8 discov]y 9 a pamphlet entitl$ 8,facts ( ,mod]n ,sci5ce10 & rec5tly publi%$ an article 9 ! ,m$ical ,record giv+ 8 ideas on ?is m9]al po9t ( view4 ,biosol is an indescribable mixture ( alcohol1 c>bohydrates1 & _m & v>i\s m9]al bodies--rang+ all ! way f sodium1 potassium1 calcium & magnesium to silicon1 copp]1 uranium & ?orium--! am\nt ( ea* be+ 9 mo/ cases extremely m9ute4 ,x is said to be a valuable food z well z m$ic9e4 ,a dose ( ?is food might keep a rabbit alive = sev]al h\rs1 & a man :o c\ld /& ! exp5se & escape dea? f delirium trem5s might live on ?ree qu>ts ( ! mixture p] day4 ,human be+s h little occasion to fe> m9]al />vation1 & may obviate :atev] dang] !re may be ) a dr9k ( milk4 ,l o!r liv+ creatures1 we may be ?ankful t we are furni%$ 9 our own bodies ) a liv+ bioplasm :i* c use ! m9]als ( ! wat]s & ! rocks & :i* has its own laboratory 9 :i* to prep>e organic comp\nds to suit its ne$s4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,m>* #h1 #aiac47 ,,brom9-,,iod9 ,,comp\nd ,! ,life-,hi/ory ( a ,no/rum ,a correspond5t writes = in=mation conc]n+ a rem$y kn[n z ,brom9-,iod9 ,comp41 :i* he says is manufactur$ by ! ,brom9-,iod9 ,*emical ,company1 =m]ly ( ,b+hamton1 ,n4 ,y41 b n[ locat$ 9 ,san ,diego1 ,calif4 ,9 ,! ,j\rnal = ,feb4 #e1 #ahih1 appe>$ an article by ,dr4 ,c4 ,w4 ,+raham1 ,b+hamton1 ,n4 ,y41 entitl$ 8,five ,ye>s' ,successful ,exp]i5ce ) a ,special ,mode ( ,treat+ ,pulmon>y ,tub]culosis40 ,?is 8special mode0 ( treatm5t consi/$ 9 us+ :at ,dr4 ,+raham call$ 8brom9-iod9 comp\nd10 :i* he said _h ! foll[+ =mula3 ,iod9 gr4 #a_/b ,brom9 gr4 #a_/ad ,phosphorus gr4 #a_/ajj ,?ymol gr4 #b_/c ,/]iliz$ oil fl4 dr4 #a ,?is 8hypod]mic treatm5t ( ph?isis0 0 widely adv]tis$ 9 ! late n9eties by ! ,brom9-,iod9 ,*emical ,co1 ,b+hamton1 ,n4 ,y41 & 0 b "o ( ! innum]able 8treatm5ts0 = pulmon>y tub]culosis t h ris51 _h _! day &1 m or less gracefully1 retir$4 ,x 0 fir/ sold 8to physicians only0 = hypod]mic adm9i/ration4 ,9 #aijf1 h[ev]1 physicians 7 told by ! company t 8if we f9d x impossible to secure y\r coop]ation 444 we w be compell$ to d bus9ess ) ! druggi/s 9 y\r locality 4440 ,app>5tly !y f\nd su* coop]ation impossible1 because a leaflet 0 issu$ to ! laity & ! /atem5t 0 made t !y int5d$ to adv]tise 8all ov] ,nor? ,am]ica 9 publications ( national & int]national circulation1 z well z 9 local newspap]s 4440 ,naturally ! laity c\ldn't be expect$ to adm9i/] ?is treatm5t by ! hypod]mic me?od & x is n surpris+ to read t 8exp]im5t has prov$ t ! same solution c be tak5 int]nally40 ,9 addition to ! adv]tis+ leaflet1 ! public also 0 provid$ ) a 8pocket cal5d> good = #bjj ye>s0 :i* conta9$ num]\s te/imonials f physicians laudatory ( ! 8brom9-iod90 treatm5t4 ,! layman :o receiv$ "o ( ! leaflets 0 told t if he 0 suff]+ f 8a/hma1 bron*itis1 colds1 consumption1 c\ghs1 eczema1 goit]1 hay fev]1 neuralgia1 rheumatism 444 also con/ipation & kidney tr\bles10 & 8 recov]y 0 8n z rapid z x %\ld be10 %\ld1 moreov]1 8 physician refuse to use ! brom9-iod9 comp\nd 8x might n be a bad idea to dis*>ge him0 & get a physician :o w\ld6 ,at ! "t ?is 8treatm5t0 0 fir/ tri$ by its 8inv5tor10 ! results giv5 9 fifty cases 73 ,fir/ /age1 #ij p] c5t4 cures2 second /age1 #ej p] c5t4 cures2 ?ird /age1 no cures1 b improvem5t 9 sev]al cases2 ?is 0 9 #ahie4 ,x n[ appe>s t ?is 8treatm5t0 has aft] a p]iod ( 8pat5t-m$ic9e0 exploitation come back into ! 8e?ical propriet>y0 field4 ,presumably a mixture su* z t repres5t$ by ! 8=mula0 did n l5d itself to adm9i/ration by m\?2 !re 0 no?+ to d1 !re=e1 b enli/ ! aid ( 8easy0 physicians 9 fur!r+ its sale4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,june #d1 #aiaj47 ,,calm9e ,new ,names = ,old ,drugs 8,calm9e1 ! new ,hypnotic10 is ano!r example ( ! +5uity ( ! exploit]s ( propriet>y prep>ations 9 co9+ new names = old drugs & ! recklessness ) :i* exploit]s h]ald =? r5am$ rem$ies to ! pr(ession & ! public z new & wond]ful discov]ies4 ,?is is :at ! promot]s1 su/a9$ by a calm confid5ce 9 ! cr$ulity ( ! pr(ession1 h to say3 ,9 ! m$ical circles ?r\gh\t ! c\ntry a good deal ( int]e/ & ev5 en?usiasm ov] ?is new hypnotic is noticeable4 ,v few drug products h attract$ s mu* att5tion z ?is "o4 ,a really satisfactory hypnotic & sleep-induc]1 :i* ,calm9e c]ta9ly seems to be1 has be5 await$ expectantly = _m ye>s4 ,( c\rse1 we h always _h ag5ts ( ?is sort--a new "o has come out at frequ5t int]vals--b none ( !m h 8fill$ ! bill02 !y h be5 prescrib$ only because !re 0 no?+ bett] to be _h4 ,n[ ?is new & wond]ful discov]y is no?+ b ,v]onal-sodium 7sodium die?yl-b>biturate7 "u ano!r "n4 ,x is ! sodium salt ( ! m or less favorably kn[n hypnotic1 ,v]onal 7die?yl-b>bituric acid74 ,x is also sold z ,m$9al1 & diff]s f ,v]onal only 9 t ! comb9ation ) sodium has made x m readibly soluble1 & ?us1 x is claim$1 its absorption is m prompt4 ,v]onal is protect$ abroad by a trade-m>k & 9 ?is c\ntry by a pat5t1 & ?is1 und\bt$ly1 is responsible = ! introduction ( ?is sodium salt "u ^! fanciful names1 because ,v]onal c\ld n be sold )\t infr++ on ! pat5t4 ,?is 9 turn induc$ ! manufactur]s ( ,v]onal1 9 self-protection1 also to put ! sodium salt on ! m>ket1 & n[ we h x "u ! "n ( ,calm9e4 ,?is probably is only ! beg9n+2 soon we may look = x "u a ho/ ( o!r names & ! usual result w foll[3 ?\ghtless physicians :o h _h poor results ) x "u "o "n w try x "u o!rs4 ,or worse /ill1 physicians w ?\ghtlessly comb9e ,v]onal ) ,calm9e or ) ,m$9al 9 ! same prescription1 ?us giv+ a dang]\s dose4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #ad1 #aiaa47 ,,camph5ol ,camph5ol is made by ,johnson ,johnson1 ,new ,brunswick1 ,n4 ,j4 ,"u ! "n ( ! article on ! c>ton appe>s ! foll[+ =mula3 ,c#aj;,h#af,o,c#f;,h#d7;,,*#c7,,oh,c#f;, h#e,,oh4 ,?is =mula consi/s ( ! *emical =mulas = camphor1 cresol & ph5ol1 writt5 "o aft] ano!r1 & f ?is "o w\ld conclude t ,camph5ol is a comp\nd ( camphor1 ph5ol & cresol 9 molecul> proportions4 ,exam9ation %[s1 h[ev]1 t ,camph5ol is b a modification ( ! well-kn[n camphorat$ ph5ol 7! liquid produc$ :5 solid camphor & ph5ol are triturat$ toge!r74 ,9 ,camph5ol a "p ( ! ph5ol1 9 ! camphorat$ ph5ol1 has be5 replac$ by cresol1 & ?is liquid has be5 dilut$ & emulsifi$ ) gelat9 or "s simil> sub/ance & p]fum$4 ,9 o!r words1 ?is prep>ation is an emulsion conta9+ relatively small quantities ( cresol1 ph5ol & camphor & is ano!r illu/ration ( ! attempts ( w\ld-be ph>maceutical h\ses to produce new syn!tics 9 ! simple/ mann] possible--t ( writ+ ! *emical =mulas ( ! con/itu5ts ( a rem$y 9 a way to indicate a *emical comb9ation4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #e1 #aiaj47 ,,*olog5 ,! propriet>y ,*olog5 is int]e/+ "s ( our read]s & sev]al h s5t u samples & lit]ature4 ,dr4 ,philip ,m>vel1 ,atlantic ,city1 ,n4 ,j41 = example1 writes3 8,by ! way1 ,i am to-day s5d+ y by mail a package :i* ! ,c\ncil on ,ph>macy & ,*emi/ry may c>e to tackle1 or x may n4 ,i %all n be insult$ any way1 b s9ce ^! *olog5 prep>ations are be+ us$ a good deal by v>i\s globe trott]s1 :o sometimes hook up = a %ort /ay "h1 ,i feel x might be ( "s int]e/ to "k #8:at fools ^! mortals be' & h[ mu* ! pr(ession is be+ fool$ ) !m40 ,*olog5 z a m$ical treatm5t = gall-/ones has be5 be=e ! ,g]man public = a numb] ( ye>s1 & x is some:at s+ul> t s simple a me?od1 :i* c\ld be easily prescrib$ by ! physician if x _h m]it1 %\ld exhibit su* rem>kable vitality 9 propriet>y =m 9 spite ( evid5ce go+ to %[ t x re/s on errone\s pr9ciples4 ,! ,c\ncil reject$ x z an unsci5tific mixture4 ,! treatm5t is some:at lib]al1 consi/+ ( ! use1 9 v>y+ successions1 ( ?ree k9ds ( tablets3 ,no4 #a1 calomel & podophyll92 ,no4 #b1 calomel1 & ,no4 #c1 calomel1 podophyll91 camphor & m5?ol4 ,! proprietors tell u t ! treatm5t %\ld be proce$$ ) 9 spite ( di/urbances1 su* z di>rhea & pa9 9 ! abdom51 & t x %\ld be repeat$ regul>ly 9 int]vals = "s ye>s1 s long z any tr\ble exi/s or recurr5ce is ?reat5$4 8,a c\rse0 ( ,*olog5 tablets %\ld be tak5 two or ?ree times a ye>1 ,no4 #a be+ giv5 = t5 days1 !n ,nos4 #a & #b = =ty days & ,no4 #c = t5 days4 ,x is wor?y ( note t exp]im5tal "w seems to h be5 p]=m$ 9 ! attempt to %[ t bile produc$ by ?is rem$y w cause ! dis9tegration & solution ( gall-/ones4 ,normal bile has a c]ta9 solv5t action on gall-/ones1 b calomel & podophyll9 h no demon/rable effect 9 increas+ ! am\nt ( bile4 ,we _h imag9$ t ^! facts 7 g5]ally kn[n4 ,x is some:at disc\rag+ to reflect t "s physicians ent]ta9 s l[ an e/imate ( _! ability to prescribe su* well-kn[n rem$ies z calomel & podophyll9 t !y mu/ use !m 9 ! fix$ comb9ations provid$ by ,dr4 ,glas]4 ,if ! self-respect+ physician does n consid] himself insult$ by a propriet>y manufactur] :o presumes to tell him h[ to use su* well-kn[n rem$ies1 ?is is a good sign t he ne$s to take a po/graduate c\rse 9 mat]ia m$ica & elem5t>y prescription-writ+4 ,we feel t m$ical writ]s mu/ be %ort ( subjects :5 !y devote pap]s to ! exploitation ( propriet>ies consi/+ ( ^! simple +r$i5ts4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,feb4 #a1 #aiac47 ,,hagee',s ,,cordial ,,( ,,cod-,,liv] ,,oil,,at ,fraud & ,deception ,connect$ ) ,s-,call$ ,cod-,liv] ,oil ,prep>ations ,,at ,see also report on ,hagee's ,cordial1 p4 #ea4 ,! introduction ( cod-liv] oil z a suppos$ly easily assimilable nutri5t & recon/ructive 0 foll[$ by its ext5sive use 9 wa/+ diseases1 especially 9 ph?isis1 9 ! treatm5t ( :i* x came to be consid]$ almo/ ess5tial1 z x 0 suppos$ to possess "s my/]i\s p[] diff]5t f t ( o!r oils4 ,its unpalatable "* l$ to v>i\s devices to r5d] x ta/eless & make x m acceptable to ! /oma*4 ,emulsions conta9+ ! oil 9 mixture ) o!r sub/ances 7 put on ! m>ket & s]v$ a useful purpose4 ,b ! oily nature1 imp]fectly conceal$1 0 disagreeable to _m1 & gradually o!r prep>ations appe>$ :i* attempt$ to reta9 ! suppos$ !rapeutic virtues ( cod-liv] oil :ile disp5s+ ) its disagreeable "*4 ,?is attempt has be5 c>ri$ to ! extreme t 9 _m ( ! cod-liv] oil prep>ations n[ on ! m>ket ! oil has be5 entirely elim9at$ & all t is left ( ! oil is ! "n4 ,?is is a species ( fraud :i* has be5 tol]at$ too long1 b :i* w be kept up s long z physicians are will+ to be dup$4 ,"s ( ^! articles are said to 8repres5t0 ! oil & to possess all its virtues4 ,o!rs are said to conta9 oil1 :ile /ill o!rs are /at$ to conta9 8all ! valuable con/itu5ts40 ,:at is ! /&>d by :i* we may det]m9e ! true value ( ^! prep>ations & by :i* we may det]m9e :e!r or n we1 & ?r\gh u our pati5ts1 are be+ humbugg$8 ,a ,,food ,,or ,,m$ic9e--,,:i*8 ,is cod-liv] oil to be consid]$ a food or a m$ic9e8 ,a food1 c]ta9ly4 ,z a food its value w consi/ 9 ! fats x conta9s4 ,^! fats are m easily oxidizable & are consid]$ m dige/ible ?an o!r fats because ( ! pres5ce ( comp\nds d]iv$ f ! liv] :i* favor its emulsification & enable x to p5etrate ! muc\s membrane m easily ?an o!r fats4 ,aside f _! nutri5t prop]ties we h no evid5ce t ! fats ( cod-liv] oil possess any !rapeutic value2 if ! oil possesses !rapeutic qualities !y mu/ reside 9 its non-fatty con/itu5ts1 & ! activity ( ^! non-fatty con/itu5ts is n ackn[l$g$ by ^? :o h inve/igat$ !m sci5tifically4 ,mo/ ph>macologi/s believe t :atev] virtue !re is 9 cod-liv] oil dep5ds on its qualities z an easily assimilable fat4 ,on ! :ole1 we mu/ conclude ) ,cu%ny t 8cod-liv] oil has n be5 %[n to h any action ap>t f t ( an easily dige/$ food1 & its sup]iority to "s o!r fats & oils has n be5 satisfactorily e/abli%$40 ,if1 !n1 ! value ( cod-liv] oil dep5ds on ! pres5ce ( fat z its nutritive con/itu5t1 ! am\nt ( fat a prep>ation conta9s w det]m9e ! wor? or wor?lessness ( su* a prep>ation2 at all ev5ts1 a prep>ation claim+ to repres5t cod-liv] oil :i* does n conta9 fat 9 "s =m is fraudul5t4 ,,h[ ,,to ,,prove ,,or ,,disprove ,,! ,,pres5ce ,,( ,,cod-,,liv] ,,oil ,fats may be *ang$ to fatty acids or to soaps1 z occurs "u ! influ5ce ( pancreatic juice 9 dige/ion1 & /ill reta9 _! nutritive value1 b x is n possible to manipulate !m 9 any way s t !y are /ill valuable z food1 & yet d n respond to easily appli$ *emical te/s :i* demon/rate _! fatty nature4 ,any prep>ation ( cod-liv] oil 9 :i* fat or fatty acid is n recognizable by prop] te/s is valueless z food1 s9ce its food value dep5ds on ! am\nt ( fat or fatty acid pres5t4 ,an elem5t>y k ( *emi/ry & ! application ( a few simple te/s w enable any physician to le>n = himself :e!r or n a prep>ation conta9s fat or fatty acids4 ,! prep>ations claim+ to 8repres5t0 cod-liv] oil are 9 liquid =m1 & if !y conta9 oil x mu/ be "o ( ! foll[+ =ms3 #a4 ,an emulsion ( ! oil :i* may be miscible ) wat]1 b f :i* ! fat t5ds to sep>ate & rise to ! top4 ,9 ?is =m ! fat c be se5 z globules "u ! microscope4 #b4 ,a solution1 result+ f ! saponification ( ! oil1 conta9+ a soap :i* usually w be alkal9e 9 reaction1 especially :5 mix$ ) wat]1 & f :i* fatty acids are sep>at$ z a precipitate :5 ! solution is acidifi$4 #c4 ,a solution ( fatty acids4 ,?is w be acid 9 reaction & w be precipitat$ by ! addition ( wat]1 9 :i* ! fatty acids are n soluble4 ,hagee's ,cordial ( ,cod-,liv] ,oil ,hagee's ,cordial ( ,cod-,liv] ,oil ,comp\nd is said to 8repres5t #cc p] c5t4 ( pure ,norwegian cod-liv] oil10 ) o!r +r$i5ts1 9 p]fect solution4 ,x is also claim$1 accord+ to ! adv]tis+ pamphlet1 t 89 ?is prep>ation we h e b5eficial con/itu5t ( ! be/ & pure/ ,norwegian cod-liv] oil40 ,put to ! above ?ree te/s1 h[ev]1 ,hagee's cordial ( cod-liv] oil is n1 #a1 an emulsion ( cod-liv] oil2 #b1 is n a saponification ( cod-liv] oil2 &1 #c1 does n conta9 fatty acids4 ,x !re=e conta9s no cod-liv] oil4 ,! only nutri5ts 9 ! mixture1 reveal$ by analysis1 are sug>1 alcohol & glyc]91 none ( :i* is conta9$ 9 cod-liv] oil4 ,9 ?is case ! manufactur] misleads by ! use ( ! ^w 8repres5ts02 he is c>eful n to say 8conta9s10 al?\gh ! av]age read] w\ld n be apt to notice ! nice di/9ction4 ,! manufactur] unwitt+ly admits t x conta9s no oil :5 he says t x 8conta9s ev]y?+ ( value except ! grease40 ,:at else !re is ( value 9 cod-liv] oil besides ! 8grease0 we d n "k4 ,c]ta9ly1 if we e/imate ! value ( ! rem$y by its nutri5t prop]ties1 x mu/ be set d[n z practically wor?less1 if n fraudul5t1 = al?\gh a mixture ( sug>1 alcohol & glyc]9 does possess c]ta9 nutri5t value1 ! mat]ials c be pur*as$ = x f> m *eaply 9 ! op5 m>ket4 ,x is evid5t t claims are made = ?is prep>ation :i* _c be sub/antiat$4 ,aga91 "s ( ! s-call$ cod-liv] oil prep>ations are t]m$ extracts ( cod-liv] oil1 b are n 9 fact made f ! oil1 b f ! cod-liv]s in/ead4 ,!y are prep>ations :i*1 if hone/ly made1 might be wor?y ( trial1 b !y are improp]ly call$ 8extracts0 ( cod-liv] oil1 s9ce !y d n conta9 ! fat1 :i* is ! active con/itu5t ( ! oil1 b ! extractives f ! liv] :i* may or may n possess !rapeutic virtues4 ,s f> z we "k1 h[ev]1 no satisfactory evid5ce is =?com+ to indicate t su* extractives h any !rapeutic value4 ,! attempt to modify cod-liv] oil = !rapeutic purposes may be pron\nc$ a failure & ! l>ge v>iety & ext5sive sale ( ^! prep>ations appe> to be ow+ to ! fact t physicians d n recall ! ord9>y facts ( *emi/ry & fail to apply simple te/s ) little te*nical skill1 b too readily accept z facts ! /atem5ts ( ! manufactur]s4--7,modifi$ f ,! ,j\rnal ,a4 ,m4 ,a41 ,oct4 #ac1 #aijf47 ,,wat]bury',s ,,comp\nd ,,once ,,m,,au ,,au ,see pp4 #ed1 #eg & #ddb4 ,mo/ ( our read]s w rememb] :at ,! ,j\rnal has publi%$ ab\t a product t us$ to be sold z 8,wat]bury's ,metaboliz$ ,cod-,liv] ,oil ,comp\nd40 ,briefly1 x 0 %[n by a report ( ! ,c\ncil on ,ph>macy & ,*emi/ry & a contribution f ! ,association's laboratory1 t ?is 8,cod-,liv] ,oil ,comp\nd0 conta9$ practically no cod-liv] oil6 ,lat] ! f$]al gov]nm5t decl>$ ! /uff misbr&$4 ,! product is n[ sold "u ! "n 8,wat]bury's ,comp\nd40 ,x 0 rec5tly /at$ 9 ?is dep>tm5t t 8,wat]bury's ,comp\nd0 0 "o ( ! propriet>y prep>ations adv]tis$ bo? 9 8display0 =m & also 9 ! =m ( an 8orig9al article10 9 ! ,army & ,navy ,m$ical ,record--a fraudul5t publication t (f]$ its editorial pages = sale4 ,physicians are n[ receiv+ f ! ,wat]bury ,*emical ,company a repr9t ( :at purports to be an editorial f ! ,army & ,navy ,m$ical ,record entitl$1 8,"o ( ,am]ica's ,mo/ ,valuable ,prep>ations40 ,! prep>ation1 ( c\rse1 is 8,wat]bury's ,comp\nd40 ,! company 9 s5d+ out ?is repr9t also reproduces on ! rev]se side ! title-head+ ( ! ,army & ,navy ,m$ical ,record4 ,all ( :i* goes to %[ t "s conc]ns n only d n m9d be+ f\nd 9 bad company1 b seem pr\d ( x4 ,by ! way1 we wond] :e!r ^? physicians :o are /ill prescrib+ ?is no/rum ?9k !y are prescrib+ a prep>ation conta9+ cod-liv] oil6--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #ae1 #aiac47 ,,collyrium-,,wye? 8,i %\ld be glad ( any in=mation ab\t ,wye?'s ,collyrium & w\ld also l to "k if ! position tak5 by ?is conc]n measures up to ! requirem5ts ( ! ,c\ncil on ,ph>macy & ,*emi/ry40 ,?is inquiry 0 receiv$ f a ,bo/on physician1 :o enclos$ ) 8 note ! lett] quot$ bel[ t he _h receiv$ f ,john ,wye? ,bro!r1 ,philadelphia1 ! mak]s ( ! prep>ation 9 "q3 8,we h y\r lett] ( ! #bb;d in/41 9 :i* y reque/ u to s5d to y =mula = #8,collyrium1' & 9 reply !reto1 beg to advise1 be+ a corporation y w1 we ?9k appreciate :y we are n at lib]ty to disclose ! v>i\s =mulas "u :i* our prep>ations are made4 ,su* is ! competition 9 ! trade t secrecy 9 ?is respect is a valuable asset4 8,y w n = a mom5t ?9k t we take ?is position ?r\gh any di/ru/ ( y\r discretion or good fai?1 b because we feel t our duty to ! /ockhold]s ( ! company prohibits u f disclos+ our =mulas4 8,let u assure y h[ev]1 t ! eyewa% conta9s only ! simple/ & mo/ h>mless rem$ies well kn[n to ! m$ical pr(ession40 ,john ,wye? ,bro!r seek ! patronage ( ! m$ical pr(ession & desire physicians to use _! prep>ations1 b 8be+ a corporation0 !y 8are n at lib]ty to disclose ! v>i\s =mulas0 ( ^! prep>ations4 ,9 o!r words1 !y expect physicians ( ! c\ntry to prescribe 8pat5t m$ic9es0 ( ^: composition !y mu/ be ignorant & to rely :olly on ! ^w ( ,john ,wye? ,bro!r z to ! innocu\sness ( ^! products4 ,! lett] is an insult to ! physician to :om x 0 writt54 ,if physicians 7 n s apa!tic 9 cases ( ?is k9d1 ! corporation ( ,john ,wye? ,bro!r w\ld long s9ce h be5 =c$ 8(f ! f5ce0--x w\ld h become ei!r a 8pat5t m$ic9e0 conc]n or w\ld h conf9$ its activities to ! manufacture ( ph>maceutical products & e?ically exploit$ propriet>ies4 ,n[ :at ab\t ?is ,collyrium-,wye?8 ,x 0 analyz$ 9 ! ,*emical ,laboratory ( ! ,am]ican ,m$ical ,association & ! *emi/s report3 8,! specim5 ( ,collyrium-,wye? exam9$ 0 a cle>1 colorless liquid hav+ a fa9t odor l b5zaldehyd4 ,qualitative te/s demon/rat$ ! pres5ce ( antipyr91 free boric acid & sodium borate4 ,acetanilid1 ammonium salts1 glyc]91 nitrates1 phosphoric acid & pyramidon 7 abs5t4 ,su* pot5t alkaloids z atrop91 coca91 homatrop9 & piloc>p91 :i* are (t5 us$ 9 ocul> surg]y1 7 n f\nd4 ,prep>ations ( gold5seal 7 n pres5t4 ,quantitive exam9ation indicat$ t ! composition ( ! prep>ation exam9$ is ess5tially z foll[s3 8,antipyr9 #j4da gm4 8,sodium borate #j4ee gm4 8,boric acid #b4ad gm4 8,wat] 7by diff]5ce7 to make #ajj4jj c4c40 ,! secret ( su* a =mula mu/ inde$ be a 8valuable asset60 ,we v5ture ! ass]tion t if ! m$ical pr(ession did its duty1 ! corporation ( ,john ,wye? ,bro!r w\ld f9d t its 8duty to ! /ockhold]s ( ! company0 con/ra9$ x to ab&on secret 8pat5t m$ic9es0 & to conf9e its activities to a legitimate l9e ( ph>maceutical products4 ,an exam9ation ( ! firm's priceli/ reveals b a v few secret-=mula prep>ations ( ! type repres5t$ by ,collyrium1 h5ce x w\ld probably n s]i\sly damage ! bus9ess ( ! firm ei!r to elim9ate all su* =mulas f its priceli/ or to enable ! physician to use !m intellig5tly1 if !y des]ve x4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,may #ag1 #aiac47 ,,diatuss9 ,dr4 ,i4 ,fleiss1 ,new ,york1 writes3 8,please /ate ! value ( ,diatuss91 ( ,bis*(f ,co1 9 p]tussis4 ,s9ce p]tussis is su* an intractable disease1 any?+ :i* promises improvem5t is apt to attract ! physician's att5tion40 ,accord+ to an adv]tis+ circul>1 issu$ by ,e4 ,bis*(f ,co1 purport+ to be a 8repr9t f ! ,muni* ,m$ical ,weekly10 ,diatuss9 is 8444 a dialysate ( ,h]b ,?ymi & ,p+uiculae40 ,! latt] is said to be kn[n 9 ! ,alps z 8blue fatwe$40 ,! only fur!r in=mation z to ! composition ( ?is prep>ation is ! /atem5t t 8! dialysate ( ?is blue fatwe$ is said by ! manufactur] to conta9 a proteolytic f]m5t40 ,! writ] ( ! article rec\nts h[1 aft] try+ a ho/ ( rem$ies1 he f9ally _h su* success 9 ! treatm5t ( :oop+-c\gh t 8444 a :ole procession ( mo!rs ) *ildr5 affect$ by :oop+-c\gh came to me f a neighbor+ village1 only because sev]al *ildr5 f ?is place _h be5 quickly cur$ by ! dialysate40 ,nev]!less1 :ile ! 8procession ( mo!rs0 appe>s to h be5 impress$ by ! virtues ( ,diatuss91 ! writ] ( ! article1 r mode/ly = contributors ( ?is sort1 admits t 8,i am1 ( c\rse1 well aw>e1 t ! small numb] ( cases "u my obs]vation all[s ( no decisive conclusion2 x is only ! object ( ^! l9es to int]e/ a wid] circle 9 te/s40--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,may #ag1 #aiac47 ,,ent]onol ,! 8,greate/ ,g]micide ,kn[n to ,sci5ce60 ,?is prep>ation is put on ! m>ket by ! ,ent]onol ,company1 ,oswego1 ,n4 ,y41 :i* decl>es t ,ent]onol is 8! greate/ antiseptic & g]micide kn[n to sci5ce10 & t x 8de/roys ! g]ms ( typhoid fev]1 acute & *ronic di>rhea1 dys5t]y1 *ol]a infantum1 *ol]a morbus1 summ] compla9t1 ,asiatic *ol]a1 etc41 )9 two h\rs40 ,! =mula furni%$ by ! company reads z foll[s3 8,ipecac1 sub4 nit4 bismu?1 latalia rad41 camphor1 lupul91 caffe9 & rheum40 ,! att5tion ( ! ,c\ncil on ,ph>macy & ,*emi/ry ( ! ,am]ican ,m$ical ,association 0 direct$ to ?is prep>ation by a correspond5t :o _h receiv$ a circul> f ! ,ent]onol ,company4 ,he s5t a doll> to ! company ask+ = a sample ( 8latalia rad40 t he might /udy ! drug botanically1 z he 0 unfamili> ) x4 ,he expect$ to receive by return mail a sample ( root or b>k1 b in/ead1 he receiv$ ?ree boxes ( ,ent]onol & ! in=mation t z 8latalia rad40 co/s f #be to #de a p\nd ! company c\ld n af=d to s5d samples4 ,9 a circul> lett] s5t out by ?is company 8latalia rad40 is said to gr[ on ! sides ( ! ,himalaya ,m\nta9s 9 ,india1 & t ! company is unable to obta9 en\gh = its own use4 ,?is /atem5t is probably correct1 & no "o else c\ld secure ! drug ei!r4 ,a sample ( ,ent]onol 0 submitt$ to ,pr(essor ,day1 ( ! ,univ]sity ( ,ill9ois1 & to ,pr(essor ,kraem] ( ! ,philadelphia ,college ( ,ph>macy4 ,pr(essor ,day reports t he 0 8unable to f9d any m5tion ( ! drug ( #8latalia rad4' :i* is /at$ z "o ( ! +r$i5ts ( ?is prep>ation4 ,i h se>*$ ! usual works ( ref]5ce on ph>macognosy )\t be+ able to f9d any ref]5ce to a drug ( ?is "n4 ,a microscopic exam9ation ( ! tablets %[s ! pres5ce ( rhub>b & ( g+]1 b no lupul91 at lea/ n 9 sub/ance2 nor c\ld ,i locate def9itely any ipecac1 also /at$ to be "o ( ! +r$i5ts4 ,s9ce g+] is n /at$ to be "o ( ! +r$i5ts ( ! comp\nd1 x1 p]haps1 may be ! my/]i\s /rang] #8latalia rad4' ,i 0 unable to locate any ( ! ord9>y a/r+5t drugs1 su* z k9o1 kram]ia1 or nutgall40 ,! results ( ,pr(essor ,kraem]'s exam9ation 7 practically id5tical ) ^? obta9$ by ,pr(essor ,day4 ,a report f ! *emical laboratory ( ! ,am]ican ,m$ical ,association /ates t z ,pr(essors ,kraem] & ,day sugge/$ ! pres5ce ( alum1 te/s 7 made = ?is sub/ance4 ,! analysis1 details ( :i* are giv51 leads to ! conclusion t alum is ! *ief con/itu5t ( ,ent]onol4 ,! report adds /rongly to ! impression t 8latalia rad40 is simply a ruse to cat* ! unw>y & tru/+ physician :o lacks ! "t to look into ! botany ( e new plant discov]$1 & :o is will+ to tru/ ! hone/y ( e manufactur]4 ,att5tion is also direct$ to ! fact t :ile bismu? & caffe9 are m5tion$ z +r$i5ts te/s made 9 ! laboratory fail$ to discov] ei!r ( ^! sub/ances4 ,s9ce !re is no lupul91 no ipecac1 no caffe91 no bismu?1 & possibly no 8latalia rad40 "o is =c$ to ! conclusion t ! 8=mula0 is mean+less & wor?less1 & t x is simply us$ to satisfy ! dem& = =mulas = propriet>y rem$ies4 ,?is is "o m beautiful illu/ration ( ! absurdity ( accept+ a prep>ation because ! 8=mula is on e package40--7,ab/ract$ f ,! ,j\rnal ,a4 ,m4 ,a41 ,m>* #ba1 #aijh47 ,an ,invitation to ,! ,j\rnal to ,humbug ! ,pr(ession ,! ,j\rnal has receiv$ a circul> lett] f ! ,ent]onol ,company1 9 :i* ! foll[+ lib]al (f] is made3 8,we are will+ to take "o-f\r? or "o-half page #8ad' 9 y\r ,j\rnal = a ye> at ! regul> rate1 on condition t y accept paym5t !re= 9 our ,,gu>ante$ #g p] c5t41 pref]r$ /ock at p>2 or if y desire1 9 ,,ent]onol at ! net :olesale price to physicians40 ,n t ?is (f] is made exclusively to ,! ,j\rnal3 8,a l>ge numb] ( m$ical j\rnals h accept$ ! =ego+ proposition2 _m c>ry+ ?is adv]tis+ = sev]al ye>s already40 8,our company is coop]ative2 we pay+ no ca% = adv]tis+4 ,! company is own$ pr9cipally by physicians1 m$ical j\rnals1 & druggi/s40 ,! j\rnals ( :i* we h record t c>ry ! ent]onol adv]tisem5t are3 ,kansas ,city ,m$ical ,record1 ,milwaukee ,m$ical ,j\rnal1 ,tol$o ,m$ical & ,surgical ,report]1 ,proctologi/1 ,p$iatrics1 & ! ,atlanta ,j\rnal-,record ( ,m$ic9e4 ,if ! /atem5ts made by ! ,ent]onol ,co4 are true1 we might inf] t ^! j\rnals are be+ paid = adv]tis+ space ei!r ) 8pref]r$ /ock0 or ) ! no/rum itself4 ,z we h previ\sly %[n1 h[ev]1 ! v]acity ( ! ent]onol adv]tis+ matt] is by no means unimpea*able4 ,ent]onol1 x w be rememb]$1 0 expos$ 9 ,! ,j\rnal1 ,m>* #ba1 #aijh4 ,x is adv]tis$ z ! 8greate/ antiseptic & g]micide kn[n to sci5ce10 & possesses 787 su* rem>kable p[] t x 8de/roys ! g]ms ( typhoid fev]1 acute & *ronic di>rhea1 dys5t]y1 *ol]a infantum1 *ol]a morbus1 summ] compla9t1 ,asiatic *ol]a1 etc41 )9 two h\rs40 8,! orig9al product is f\nd only high up on ! sides ( ! l(tie/ m\nta9s 9 ! _w--! ,himalayas ( ,india40 ,,! 8,,lit]ature0 ,,=mula ,( c\rse1 x has a 8=mula03 ,ipecac ,lupul9 ,sub4 nit bismu? ,latalia rad4 ,caffe9 ,camphor ,rheum ,?is seems v op5 & above bo>d1 except z to quantities1 until "o tries to f9d out :at 8latalia rad40 is2 !n x is discov]$ t x is ! 8my/]i\s /rang]0 ( ph>macognosy4 ,exp]ts to :om ?is 8rem$y0 0 submitt$ 7 unable ev5 to f9d m5tion ( su* a drug or plant z 8latalia rad40 ,nor 0 ?is ! only fake f\nd conc]n+ ! /uff2 c>efully conduct$ exp]im5ts repeat$ly c>ri$ out 9 ! ,association's laboratory fail$ to disclose ev5 a trace ( bismu? subnitrate or caffe94 ,^! exp]im5ts did %[1 h[ev]1 t ! tablets conta9$ an am\nt ( alum9um correspond+ to ov] #be p] c5t4 ( cry/alliz$ alum4 ,?is l$ to ! conclusion t alum1 ^: pres5ce is n ev5 h9t$ at 9 ! 8=mula10 is ! *ief con/itu5t ( ent]onol & z a coroll>y t ! =mula is mean+less & wor?less4 ,,! ,,label ,,=mula ,!re is a curi\s lack ( coord9ation betwe5 ! 8=mula0 z pr9t$ on ! label & t giv5 9 ! 8lit]ature40 ,! ,food & ,drugs ,act1 x w be rememb]$1 makes ly+ on ! label illegal1 & !re=e dang]\s2 /atem5ts 9 adv]tis+ matt] t does n accompany ! product1 h[ev]1 are n controll$ by t law4 ,! 8=mula0 9 ! 8lit]ature0 we h already giv52 ! 8=mula0 on ! label gives ! foll[+ +r$i5ts3 ,ipecac ,lupul9 ,sub4 nit4 bismu? ,opium1 #a_/d gr4 ,caffe9 ,camphor ,rheum ,two ?+s ab\t ?is are wor? not+3 ,"o is t ! "n ( ! +r$i5t on :i* ! manufactur] lays s mu* /ress--latalia rad41 ! my/]i\s ,himalayan plant--is abs5t f ! label4 ,?is w\ld seem to indicate t :at has already be5 intimat$ by ,! ,j\rnal--namely1 t latalia rad4 is a figm5t ( ! imag9ation--is a fact4 ,! second noticeable ?+ ab\t ! label 8=mula10 z di/9ct f ! 8=mula0 9 ! adv]tis+ matt]1 is t on ! label we f9d !re is opium 9 ! prep>ation4 ,:y is no m5tion made ( ! pres5ce ( ?is pot5t drug 9 ! adv]tis+ matt]8 ,to det]m9e h[ ne>ly ! pres5t /atem5ts made by ! ,ent]onol ,company approximate tru?fulness1 our *emi/s 7 ask$ to exam9e ! no/rum z x is n[ sold4 ,_! report foll[s3 ,,laboratory ,,f9d+s ,an orig9al package ( ent]onol tablets 0 pur*as$ on ! op5 m>ket & submitt$ to ! ,association laboratory = exam9ation4 ,9 g5]al appe>ance1 odor & ta/e ! new tablets are simil> to ^? previ\sly exam9$4 ,! =mula = ! old tablets 0 giv5 z 8,ipecac1 ,sub4 nit4 bismu?1 ,latalia rad41 ,camphor1 ,lupul91 ,caffe91 ,rheum10 & is /ill us$ 9 ! circul>4 ,b ! label on ! trade package no long] m5tions 8latalia rad40 ,s9ce ! pres5ce ( 8latalia rad410 9 ! old tablets1 0 que/ion$1 & z new labels h ceas$ to display ! "n1 x 0 ?\ght possible t caffe9 & bismu? might n[ be con/itu5ts ( ent]onol1 z ! drugs are /ill m5tion$ 9 ! new =mula on ! label4 ,accord+ly1 ent]onol 0 exam9$ *emically to v]ify ! /atem5ts on ! label reg>d+ ! pres5ce ( caffe9 & bismu? 9 ! tablets4 ,! specim5 submitt$ to ! laboratory "s "t ago 0 f\nd to conta9 nei!r bismu? nor caffe94 ,by employ+ ! same me?ods z 7 us$ be=e 7! usual te/s = detect+ caffe9 & bismu?71 nei!r caffe9 nor bismu? c\ld be demon/rat$4 ,x is ?us evid5t t ?is new specim5 ( ent]onol1 ! /atem5t on ! label to ! contr>y not)/&+1 conta9s nei!r bismu? nor caffe9--at lea/1 9 appreciable quantities4 ,"o w\ld ?9k t ! discrepancy betwe5 8=mulas0 & facts w\ld prove ( int]e/ to ! /ockhold]s ( ! ,ent]onol ,company1 especially z we are told t ! policy ( ! company is to h 8practical m5 z /ockhold]s40 ,we are in=m$3 8,!re=e1 we h physicians1 adv]tis+ exp]ts1 pr9t]s1 publi%]s1 engrav]s1 boxmak]s1 li?ograph]s1 druggi/s1 lawy]s1 travel+ salesm51 (fic]s & m5 hold+ executive positions 9 v>i\s manufactur+ & comm]cial corporations1 editors ( m$ical publications1 bi%ops1 cl]gym5 & mission>ies--m5 f all ! fields p>ticul>ly valuable comm]cially = our great ent]prise40 ,yet if ! physician-/ockhold]s d n c>e to conc]n !mselves ab\t ! composition ( ! no/rum f ! sale ( :i* !y d]ive divid5ds1 x c h>dly be expect$ t ! boxmak]s or travel+ salesm5 w be int]e/$4 ,,/ock ,,= ,,sale ,m$ical j\rnals are n alone 9 be+ invit$ to p>ticipate 9 ! exploitation ( ?is no/rum1 vide a circul> lett] f ! ,ent]onol ,company address$ 8,to ,inve/ors03 8,we (f] at p> ( #aj ea*1 #a1jjj %>es ( our ,gu>ante$ #g p] c5t4 ,pref]r$ ,/ock1 cumulative divid5ds1 payable qu>t]ly 444 ,pr(its on bus9ess done la/ ye> 7 #ed c5ts = e doll> exp5d$ 444 ,we gu>antee absolute security = y\r inve/m5t4 ,saf] ?an a bank40 ,italics ours4--,ed4 ,we are told t at pres5t ! ,ent]onol ,company manufactures two products3 a ca/or-oil prep>ation1 kn[n z fig-ol1 & ent]onol4 ,v %ortly1 h[ev]1 ! company expects to 8add sev5 equally effici5t products40 8,! av]age co/ to manufacture1 ready to %ip1 a doll>'s wor? ( ^! goods is less ?an t5 c5ts40 8,9 ent]onol alone1 ! company has =tunes & ! only ?+ ne$$ to br+ trem5d\s results & divid5ds ( #ajj p] c5t4 is ! prop] am\nt ( judici\s adv]tis+40 ,"h are "s samples ( ! judici\s 787 adv]tis+3 8,"o ,*ri/ian mission>y1 ! ,rev4 ,paul ,s+h ( ,jubbulpore1 ,india1 te/ifies t he cur$ ?irte5 sev]e cases ( ,asiatic ,*ol]a ) a box conta9+ less ?an ?irty tablets0 ( ent]onol4 8,wm4 ,f4 ,oldham1 bi%op ( ,s\!rn ,asia1 writes u t ent]onol cur$ n9e cases out ( t5 ( ,asiatic ,*ol]a4 ,n[ j ?9k ( ,india & ,*9a ) _! #hjj1jjj1jjj p :o are dy+ by ! ?\s&s ( a disease :i* we h ! p[] to cure s easily40 ,h[ l a disc\rse by t delightful "* ( ,m>k ,twa9's--! vision>y ,colonel ,sell]s--?is reads4 ,z he said ab\t 8 8,infallible1 ,imp]ial1 ,ori5tal ,optic ,l9im5t03 8,:y 9 ! ,ori5tal c\ntries 444 e squ>e mile ( gr\nd upholds its ?\s&s on ?\s&s ( /ruggl+ human creatures--& e sep>ate & individual devil ( !m's got ! oph?almia40 ,! prospective /ockhold] is told t an ord9>y bus9ess conc]n rea*es ! limit ( f9ancial possibilities 9 a few ye>s1 b3 8,n s ) ! ,ent]onol ,company--x is a mail-ord] bus9ess & ! _w is its t]ritory40 ,ev5 s ) ,colonel ,sell]s' 8,optic ,l9im5t03 8444 x's a pat5t m$ic9e ^: field ( op]ations is ! solid e>?40 ,& we are told else:]e t 8ab\t f\r-fif?s ( ! out/&+ /ock is held by ! m$ical pr(ession alone06 ,& ?is /uff is adv]tis$ 9 m$ical j\rnals66 ,we are sometimes 9 dang] ( be+ too optimi/ic reg>d+ ! results ( ! propag&a = re=m 9 propriet>y m$ic9e4 ,cases l ?is act z a corrective4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #bj1 #aiji47 ,,expurgo 7,,sanol7 ,,anti-,,diabetes ,"o ,m ,fraudul5t ,no/rum = ,diabetes ,expurgo ,anti-,diabetes is sold & adv]tis$ 9 ! ,unit$ ,/ates by ! ,expurgo ,manufactur+ ,company1 ,*icago4 ,! conc]n is ! ,unit$ ,/ates bran* ( a ,canadian company1 ! ,sanol ,manufactur+ ,company1 ,ltd41 ,w9nipeg1 :i* sells its product 9 ,canada "u ! "n ( 8,sanol ,anti-,diabetes40 ,! p>5t company is said to h be5 incorporat$ "u ! ,manitoba laws 9 #aiab & to h = its (fic]s & directors ! foll[+ m53 ,*>les ,bey]1 ,presid5t4 ,frank ,bey]1 ,vice-,presid5t4 ,*>les ,bau]1 ,secret>y-,treasur] & ,manag]4 ,! manag] ( ! ,unit$ ,/ates bran* 9 ,*icago is said to be "o ,e4 ,m4 von ,am]ong54 ,! /uff is su* an evid5t fraud t "o w\ld imag9e t ev5 intellig5t laym5 c\ld n be deceiv$ by x4 ,nev]!less m$ical j\rnals bo? 9 ! ,unit$ ,/ates & ,canada h accept$ adv]tisem5ts = ?is prep>ation & physicians--( a c]ta9 type--h be5 f\nd to give te/imonials = x4 ,! m$ical pr(ession is circul>iz$ widely by ! conc]n & 8write-ups0 h appe>$ 9 pseudom$ical j\rnals4 ,"s ( ! claims made = ,expurgo ,anti-,diabetes are3 8,! only positive cure = ,diabetes40 8,x nev] fails to effect a ,cure 9 e case ( ?is disease1 9 :atev] =m x may pres5t itself provid$ ! pati5t has n rea*$ ! la/ /ages ( ! malady40 8,expurgo ,anti-,diabetes is ! ,new ,cure = ?is deadly affliction40 8,diabetes is c]ta9ly curable by our new discov]y--,expurgo ,anti-,diabetes1 provid$ t ! c\rse ( ! disease has n progress$ to ! ext5t t ! vital organs are irrep>ably damag$40 8444 ?anks to ! discov]y ( ,expurgo ,anti-,diabetes1 ! cure ( ?is dread disease is no long] a matt] ( d\bt40 8,) ! exception ( v advanc$ cases ( ,diabetes 444 all diabetes c be cur$ by ,expurgo ,anti-,diabetes40 ,su* claims "o w\ld imag9e w\ld be m ?an suffici5t to make pla91 ev5 to ! mo/ uncritical ( physicians1 ! evid5t fraudul5ce ( ,expurgo ,anti-,diabetes4 ,nev]!less1 ! adv]tisem5ts ( ?is fraud h appe>$ dur+ #aiac 9 ! foll[+ m$ical j\rnals3 ,m$ical ,times ,m$ical ,brief ,m$ical ,summ>y ,buffalo ,m$ical ,j\rnal ,l\isville ,mon?ly ,j\rnal ,i[a ,m$ical ,j\rnal ,canada ,lancet ,detroit ,m$ical ,j\rnal ,m$ical ,h]ald ,m$ical ,review ( ,reviews ,m$ical ,/&>d ,m$ical ,review ,!rapeutic ,record ,m$ical ,=tnightly ,indianapolis ,m$ical ,j\rnal ,s\?we/ ,j\rnal ( ,m$ic9e & ,surg]y ,we/]n ,canada ,m$ical ,j\rnal ,dom9ion ,m$ical ,mon?ly ,canadian ,m$ical ,association ,j\rnal ,canadian ,practition] & ,review ,massa*usetts ,m$ical ,j\rnal ,physicians w recognize t1 ) b few exceptions1 mo/ ( ^! j\rnals are utt]ly unrepres5tative ( sci5tific m$ic9e4 ,! ,army & ,navy ,m$ical ,record1 %[n 9 ,! ,j\rnal rec5tly z a j\rnali/ic fraud1 conta9$ an editorial puff ( ,expurgo ,anti-,diabetes4 ,! fact t ! ,expurgo ,company repr9ts ! 8editorial0 f ! ,army & ,navy ,m$ical ,record z a 8volunt>y & unsolicit$ ref]5ce0 & di/ributes x among physicians1 indicates h[ rott5 are ! props on :i* ! sup]/ructure ( ?is fraud re/4 ,ano!r alleg$ 8volunt>y & unsolicit$ ref]5ce0 us$ by ! ,expurgo ,company is tak5 f ! ,!rapeutic ,record ( ,l\isville1 ,k5tucky4 ,! adv]tis+ pages ( ! ,!rapeutic ,record reek ) frauds & x has m ?an once giv5 editorial endorsem5t to "s ( ! frauds t x adv]tises4 ,! foll[+ enlight5+ lett] is alleg$ to h be5 writt5 by ! editor ( ! ,!rapeutic ,record to ! ,expurgo ,company 9 ,febru>y1 #aiac3 ,g5tlem53--,y\r favor ( ,febru>y #ad? came duly to h&4 ,let me advise y to pay no e>?ly att5tion to ! proce$+s ( ! ,m$ical ,society :]e y\r product 0 criticiz$4 ,^! p ex]t no influ5ce ) ! practical up-to-date elem5t ( ! pr(ession & are do+ y z !y d o!rs4 ,nev] fe>--y w succe$--y\r rem$y is all "r4 ,no man c talk d[n a m]itori\s product4 ,i /& ready to help y 9 any way at any "t4 ,) s9c]e reg>ds1 ,i am1 ,rob]t ,c4 ,k5n]1 ,m4,d41 ,editor1 ! ,!rapeutic ,record4 ,?is1 x w be notic$1 0 writt5 9 ,febru>y4 ,soon !reaft] ! ,!rapeutic ,record 0 c>ry+ ! ,expurgo adv]tisem5t1 & ! ,june1 #aiac1 issue conta9$ a puff on ,expurgo1 entitl$ 8,a ,contribution to ! ,m$ical ,treatm5t ( ,diabetes40 ,! quid pro quo is fairly evid5t4 ,,! ,,alleg$ ,,=mula ,! =mula = ?is no/rum is nev] publi%$1 al?\gh 9 "s ( ! adv]tis+ matt] x is claim$ t x is 8at ! disposal ( physicians40 ,a physician wrote to ! ,expurgo ,manufactur+ ,company1 ask+ = ! =mula4 ,he 0 told t ! prep>ation 0 8exclusively d]iv$ f ! vegetable k+dom10 f :i* "o may recognize a family lik5ess to ! 8dope0 put out by ! immortal ,lydia ,p9kham4 ,fur!r1 to copy ! lett] exactly3 8,! +r$i5ts ( :i* ,antidiabetes is compos$ are *iefly3 8fructus syzigii jambulani 8cortex syzigii jambulani 8flores ,rosm>9i 8fructus ,anisi /ellati 8,extr4 fl4 ,col 8,extr4 fl4 ,condurango 8,extr4 fl4 ,*9 spir4 spiss4 8,extr4 fl4 ,calami 8,extr4 fl4 ,g5tian40 ,! recipi5t ( ?is noncommittal & un9=m+ 8=mula0 aga9 wrote ! ,expurgo ,manufactur+ ,company1 ask+ = quantities4 ,evid5tly ?is no/rum conc]n consid]$ su* a reque/ a piece ( imp]t95t inquisitiv5ess1 = x repli$ to ! physician 9 ^! t]ms1 giv5 v]batim et lit]atim3 8,de> ,sir3--,y\rs ( ! #af? duly to h&4 ,we note t y /ate #8444 ,i d n l to be work+ 9 ! d>k1 & y c readily see t ?is is ! case unless ,i "k h[ mu* ( ea* +r$i5t ,i am giv+4444' 8,9 y\r lett] ( ! #f? y ask$ = ! composition1 :i* y promptly receiv$4 ,we w\ld l to /ate t we are deal+ ) ab\t #fjj ,doctors4 ,"s ( !m ask$ = ! =mula1 :i* !y receiv$4 ,!y are all v consci5ti\s g5tlem5 & none ( !m ev] pret5d$ #8to "w 9 ! d>k4' ,y "k fur!rmore t none ( ^! +r$i5ts is h>mful 9 any way & yet #8"w 9 ! d>k4' ,y "k t if !re 7 any h>mful +r$i5ts 9 our prep>ations1 we w\ld expose ourselves to imprisonm5t4 ,if y are s anxi\s to "k all ab\t x1 :y d y n analyse our m$ic9e8 ,?is w\ld enlight5 y 9 y\r #8p]fect d>kness4' ,if y want to deprive y\r pati5ts & y\rselves ( ! indisputable good ( our prep>ations1 simply d n prescribe !m4 ,:y f9ally d y n write to ! ,doctors ^: names we gave1 :o "k en\gh to be able to enlight5 ^? :o ne$ x4 ,truly y\rs ,! ,expurgo ,mfg4 ,co41 ,c4 ,m4 v4 ,am]ong51 ,manag]4 ,m ?an a ye> ago1 a ,wiscons9 physician1 himself a suff]] f diabetes1 wrote ,! ,j\rnal t = ?ree mon?s he _h be5 us+ ,expurgo ,anti-,diabetes :i* ! ,expurgo p _h s5t him4 ,he decl>$ t ! no/rum _h greatly r$uc$ ! p]c5tage ( sug> 9 8 ur9e4 ,9 its reply1 ,! ,j\rnal ask$ him :e!r1 9 te/+ 8 ur9e he _h us$ portions ( tw5ty-f\r h\r specim5s or m]ely individual specim5s4 ,8 att5tion 0 call$ to ! fact t mo/ ( ! no/rums = diabetes are diuretics :i*1 by increas+ ! am\nt ( ur9e pass$1 give an app>5t decrease 9 ! am\nt ( sug> excret$4 ,a few days lat]1 ! physician wrote aga91 /at+ t he _h committ$ ! v error ,! ,j\rnal _h suspect$1 & report+ t an exam9ation ( a tw5ty-f\r-h\r specim5 %[$ t ! glucose-excretion1 in/ead ( be+ dim9i%$1 actually increas$4 ,?is matt] 0 ref]r$ to editorially 9 ,! ,j\rnal1 ,nov4 #i1 #aiab1 "u ! title1 8,a ,possible ,fallacy 9 ,te/+ ,diabetic ,ur9e40 ,specim5s ( ,expurgo ,anti-,diabetes 7 exam9$ 9 ! ,association's laboratory & ! *emi/'s report foll[s3 ,,laboratory ,,report ,illu/ration3 ,! lett] head ( ! ,expurgo ,manufactur+ ,co4 ,note ! claim t ,expurgo ,anti-,diabetes is 8! only positive cure = diabetes40 ,& ?is /uff is foi/$ on ! pr(ession ?r\gh ! m$ical press6 8,! specim5 ( ,expurgo ,anti-,diabetes 7,sanol ,anti-,diabetes7 exam9$1 0 a light-br[n1 opaque liquid1 hav+ a fa9tly aromatic odor & bitt] ta/e4 ,! specim5 conta9$ consid]able am\nts ( br[n1 insoluble residue resembl+ ! deposits (t5 f\nd 9 fluid extracts4 ,! abs5ce ( ammonium salts1 iodids1 glyc]91 hexame?yl5am91 ( antipyr91 pyramidon & simil> sub/ances & ( su* purgatives z aloes1 frangula1 rhub>b1 etc41 0 indicat$4 ,pot5t alkaloids su* z aconit91 coca91 morph9 & /ry*n9 7 n f\nd4 ,qualitative te/s indicat$ ! pres5ce ( traces ( phosphates1 sulphates1 r$uc+ sug>s1 caffe9 & c9*ona alkaloids4 ,alcohol 0 pres5t only 9 traces4 ,small quantities ( *lorids1 sodium & a salicylate 7 f\nd4 ,! residue on dry+ am\nt$ to #b4i gm4 9 ea* #ajj c4c4 ,a det]m9ation ( ! salicylic acid indicat$ approximately #j4ag gm4 9 ea* #ajj c4c41 :i* is equival5t to less ?an #j4b gm4 ( sodium salicylate p] #ajj c4c4 7ab\t #a gra9 to ! ounce74 ,evid5tly ! prep>ation conta9s plant extractives 9 aque\s solution & small am\nts ( sodium salicylate & sodium *lorid40 ,summ$ up1 ! *emi/'s report %[s t ,expurgo ,anti-,diabetes is ess5tially a wat]y solution ( plant extractives ) small quantities ( sodium salicylate & salt4 ,! exploit]s claim _! /uff conta9s ! fruit & b>k ( jambul1 rosem>y1 /> anise & fluid extract ( calamus1 c9*ona1 cola1 condurango1 & g5tian4 ,s9ce fluidextracts 9 g5]al are /rongly alcoholic & s9ce ! laboratory's analysis %[s t ! prep>ation conta9s only traces ( alcohol1 ! fluidextracts ( ! v>i\s drugs1 if pres5t at all1 mu/ be 9 an inf9itesimal am\nt4 ,jambul 0 9 vogue z a rem$y = diabetes ab\t tw5ty ye>s ago4 ,x 0 tri$ & f\nd want+1 & has long s9ce be5 relegat$ to ! !rapeutic scrap heap4 ,sanol1 !re=e1 is b "o m propriet>y humbug1 foi/$ on ! pr(ession "u fraudul5t claims1 & hav+ = its ess5tial con/itu5t a drug t has long be5 disc>d$ by sci5tific m5 & resurrect$ = ! purposes ( quack]y4 ,expurgo w probably be us$ by uncritical & un?9k+ physicians & its exi/5ce w be artificially prolong$ ?r\gh ! v5ality ( pseudo-m$ical j\rnals4 ,t ! m$ical pr(ession %\ld tol]ate su* an evid5t fraud is n to its cr$it4 ,!re is no excuse1 ei!r moral or o!rwise1 = a physician giv+ 8 pati5ts no/rums ( ^: composition he is ignorant1 & t is :at is done :5ev] ,expurgo ,anti-,diabetes is prescrib$4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #bd1 #aiad47 ,,=mam9t ,! ,pr(ession to ,be ,work$ ,aga9 ,=mam9t ,tablets are widely adv]tis$ & extravagantly exploit$ to ! laity 9 ,great ,brita94 ,l>ge & exp5sive adv]tisem5ts appe> 9 ! ,engli% magaz9es & newspap]s & ! tablets are pu%$ "u ! mo/ prepo/]\s claims4 ,! prep>ation is put out1 we und]/&1 by ! same conc]n t exploits ,sanatog54 ,! m$ical pr(ession ( ?is c\ntry is n[ be+ circul>iz$ & adv]tisem5ts are appe>+ 9 m$ical j\rnals4 ,!y already appe> 9 ! ,m$ical ,record1 ,new ,york ,m$ical ,j\rnal & ,am]ican ,j\rnal ( ,cl9ical ,m$ic9e4 ,x seems !n t ?is is ano!r product :i*1 = ! "t be+ at lea/1 is to be a 8pat5t m$ic9e0 on ! o!r side ( ! ,atlantic & an 8e?ical propriet>y0 on ?is4 ,d\btless ! di/9ction w be a tempor>y "o & z soon z ,am]ican physicians h furni%$ ! requisite numb] ( te/imonials & h recomm5d$ x to a suffici5t numb] ( _! pati5ts ! adv]tisem5ts w be quietly dropp$ f ! ,am]ican m$ical j\rnals & ! adv]tis+ pages ( newspap]s & magaz9es w be call$ into s]vice4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #bg1 #aiab47 ,! ,s-,call$ ,g]m-,kill+ ,?roat ,tablet ,=mam9t tablets h rec5tly be5 put on ! ,am]ican m>ket by ! same conc]n t exploits ,sanatog51 ! 8food tonic0 or 8tonic food0--accord+ to :e!r "o reads ,european or ,am]ican newspap]s4 ,=mam9t tablets are be+ introduc$ to ! ,am]ican public by t *eape/ ( all me?ods ( adv]tis+ 8pat5t m$ic9es10 ?r\gh ! m$ical pr(ession4 ,x is n adv]tis$ 9 ,am]ican newspap]s or lay magaz9es--at pres5t4 ,= "s ye>s ?is product has be5 adv]tis$ 9 newspap]s & o!r p]iodicals 9 ,europe "u su* claims z ! foll[+3 8,=mam9t %ields humanity aga9/ infecti\s disease40 8,cures & prev5ts sore ?roat40 8,! dang]s ( infection f diseases l diph!ria1 sc>let fev]1 measles1 tonsillitis1 sore ?roat1 mumps1 etc41 h n[ be5 r$uc$ to an absolute m9imum4 ,?is is due to ! discov]y ( ,wulf+'s ,=mam9t--! #8g]m-kill+ ?roat tablet4'0 8,cleanses ! m\? & ?roat f disease g]ms z easily & rapidly z dirt is remov$ f ! sk940 8,=mam9t w c]ta9ly prev5t diph!ria40 8,quickly r5d] ! :ole m\? & ?roat ?or\ghly antiseptic40 8,=mam9t de/roys ^! diph!ria g]ms s rapidly t :5 a physician mix$ a little ,=mam9t ) wat] & add$ x to ! g]ms tak5 f ! ?roat ( a pati5t dang]\sly ill ) diph!ria !y 7 all kill$ )9 t5 m9utes40 ,su* are "s ( ! claims by :i* ,=mam9t goes to ! ,european public4 ,d\btless x w be only a matt] ( "t :5 ! requir$ numb] ( te/imonials f ,am]ican physicians are =?com+ :5 we may expect to f9d ! newspap]s ( ?is c\ntry h]ald+ ?r\gh _! adv]tis+ pages ! fact t ,=mam9t is 8recomm5d$ by ?\s&s ( ,am]ican physicians40 ,! m$ical j\rnals t are l5d+ _! pages to ?is prelim9>y adv]tis+ campaign are ! foll[+3 ,new ,york ,m$ical ,j\rnal ,m$ical ,record ,am]ican ,m$ic9e ,am]ican ,j\rnal ( ,cl9ical ,m$ic9e ,m$ical ,review ( ,reviews ,h[ mu* long] w ! m$ical pr(ession p]mit itself to be us$ z an unwitt+ ag5cy = ! exploitation ( 8pat5t m$ic9es08 ,! game has be5 work$ s (t5 t x has become transp>5tly ?94 ,x is evid5tly n worn out1 h[ev]1 or %rewd no/rum promot]s w\ld n wa/e _! "t or money on x4 ,t x %\ld /ill be consid]$ workable is complim5t>y nei!r to ! /&>d ( adv]tis+ e?ics ( m$ical j\rnals t accept ! ,=mam9t adv]tisem5ts nor to ! intellig5ce ( ! memb]s ( ! m$ical pr(ession :o w 8fall = x40--7,! ,j\rnal ,a4 ,m4 ,a41 ,feb4 #bd1 #aiab47 ,,gom5ol ,a correspond5t s5ds "s adv]tis+ matt] on ,gom5ol & calls att5tion to ! numb] ( diseases = :i* ! prep>ation is recomm5d$3 ,gom5ol is app>5tly a volatile oil4 ,x is a propriet>y said to come f ,france1 & to be prep>$ f a species ( cajuput 7,melaleuca viridiflora1 ,ga]tn474 ,?is plant is closely relat$ to ! cajuput tree or swamp tea-tree 7,melaleuca leucod5dron1 ,l9n7 f :i* ! (ficial oil ( cajuput is obta9$4 ,! oils f ^! two plants are v simil> 9 composition & presumably 9 !rapeutic prop]ties4 ,! oil ( ! fir/-nam$ plant appe>s n to be m>ket$ except 9 ! =m ( ! propriet>y1 ,gom5ol4 ,x probably has no advantage ov] ! (ficial oil ( cajuput1 :ile 9 ! =m ( ,gom5ol x co/s ab\t f\r times z mu*4 ,! foll[+ are "s ( ! claims made = ,gom5ol 9 ! adv]tis+ circul>s4 ,!y ne$ no comm5t4 8,a real specific = suppurations & cat>rh4444 ,x immunizes tissues1 excites _! vitality & favors ! =mation ( new cells4444 8,! lea/ trace ( ,gom5ol prev5ts ! gr[? 9 vitro ( ! /reptococcus1 ! tub]cul\s bacillus & ! gonococcus40--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,april #d1 #aiad47 ,,heada*e ,,cures,,av ,h>mful ,effects ( ,acetanilid1 ,antipyr9 & ,acetph5etid9 ,,av ,see also report on ,acetanilid ,mixtures1 p4 #i4 ,! ,unit$ ,/ates ,dep>tm5t ( ,agriculture ,bullet9#ajg ,no4 #abf1 issu$ ,july #c1 #aiji1 sets =? ! results ( an inve/igation conduct$ by ! ,bureau ( ,*emi/ry ) reg>d to ! h>mful effects ( acetanilid1 antipyr9 & acetph5etid94 ,dur+ rec5t ye>s ! use ( ^! rem$ies & prep>ations conta9+ !m by ! p at l>ge1 )\t ! sup]vision ( ! physician1 has increas$ rapidly & inve/igation has %[n t co9cid5tly !re has be5 a m>k$ increase 9 ! numb] ( cases ( poison+ report$1 9 ! numb] ( fatalities1 & 9 ! numb] ( in/ances ( habitual use4 #ajg ,! ,h>mful ,effects ( ,acetanilid1 ,antipyr9 & ,ph5acet91 by ,l4 ,f4 ,kebl]1 ,ph4,g41 ,m4,d41 *ief ,division ( ,drugs1 ,bureau ( ,*emi/ry1 ) ! collaboration ( ,drs4 ,f4 ,p4 ,morgan & ,philip ,rupp1 assi/ant *emi/s4 ,s9ce ! passage ( ! ,food & ,drugs ,act1 ,june #cj1 #aijf1 ! att5tion ( ! ,dep>tm5t ( ,agriculture has be5 direct$ to ?is subject1 p>ticul>ly 9 connection ) ! br&+ ( drug products conta9+ "o or m ( ^! ag5ts1 & an attempt has be5 made to obta9 full & reliable data ) reg>d to _! poison\s qualities ) ! object ( furni%+ in=mation to ! public :i* w\ld enable !m to und]/& t ^! rem$ies %\ld be employ$ ) caution 9 ! abs5ce ( reliable m$ical advice4 ,! in=mation obta9$ ) reg>d to ! numb] ( an inquiry address$ to m$ical practition]s 9 ! ,unit$ ,/ates ) reg>d to _! p]sonal exp]i5ce ) ^! drugs2 &1 second1 ! /udy ( ! cases ( poison+ record$ 9 m$ical lit]ature4 ,ne>ly a ?\s& lett]s1 ea* conta9+ eighte5 que/ions1 7 address$ by ! dep>tm5t to physicians ?r\gh\t ! c\ntry1 ! object be+ to secure in=mation :i* w\ld repres5t z closely z possible ! conditions exi/+ among ! p at l>ge s f> z ! h>mful effects ( ! drugs 9 "q are conc]n$4 ,f\r hundr$ replies 7 receiv$4 ,! in=mation obta9$ ) reg>d to ! numb] ( in/ances quot$ 9 m$ical lit]ature 9 :i* poison+1 dea?1 or habitual use has be5 kn[n to result f ! adm9i/ration ( acetanilid1 antipyr91 & acetph5etid9 is set =? 9 ,section ,a ( ! accompany+ table4 ,! in=mation summ>iz$ 9 ,section ,b is bas$ on ! data submitt$ by physicians4 ,grant+ t ! #ebe physicians :o did n reply _h no cases to report1 ! "q may pr(itably be ask$1 if #ibe physicians h obs]v$ #had cases ( poison+ by ^! drugs1 #bh dea?s :i* are attribut$ to _! use1 & #acf in/ances ( habitual use1 h[ _m su* cases h 9 all probability be5 obs]v$ by ! #abe1jjj physicians scatt]$ ?r\gh\t ! ,unit$ ,/ates8 ,! summ>y1 ,c1 includes bo? ! numb] ( cases record$ 9 m$ical lit]ature & ^? report$ by physicians4 ,,poison+ ,,by ,,acetanilid1 ,,antipyr9 ,,& ,,ph5acet9 ,a4--,cases ,record$ 9 ,m$ical ,lit]ature ,,habitual ,,poison+4 ,,dea?4 ,,use4 ,acetanilid #big #ac #cb ,antipyr9 #dhh #aj 44 ,acetph5etid9 #gj #c #a --- -- -- ,total #hee #bf #cc ,b4--,data ,submitt$ by ,physicians ,,habitual ,,poison+4 ,,dea?4 ,,use4 ,acetanilid #fad #af #aab ,antipyr9 #aje #e #g ,acetph5etid9 #ie #g #ag --- -- -- ,total #had #bh #acf ,c4--,total ,numb] ( ,cases ,,habitual ,,poison+4 ,,dea?4 ,,use4 ,acetanilid #iaa #bi #add ,antipyr9 #eic #ae #g ,acetph5etid9 #afe #aj #ah ---- -- --- ,total #a1ffi #ed #afi ,! bullet9 conta9s in=mation ) reg>d to dosage1 ! ext5t to :i* ^! drugs are employ$ by physicians1 poison+ & habitual use1 ! nature ( ! ill effects produc$1 etc4 ,x also conta9s ref]5ces to ! record$ cases ( poison+1 toge!r ) a brief ab/ract ( ea* case4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,july #ca1 #aiji47 ,sanatoriums & ! ,acetanilid ,habit ,to ! ,editor3--,i enclose h]e) a 8=m0 lett] & "q blank :i* ,i receiv$ rec5tly f ,/4 ,l\is4 ,i may be entirely too w>y b ,i am suspici\s t ?is is a collection ( 8/ati/ics0 to combat ! "w ( ! m$ical pr(ession 9 educat+ ! physician & ! laity 9 ! h>mfulness ( acetanilid & simil> prep>ations4 ,g4 ,h4 ,b5ton1 ,m4,d41 ,*e/]1 ,w4 ,va4 ,/]l+-,wor? ,sanit>ium4 ,comm5t3 ,! lett] :i* ,dr4 ,b5ton encloses is 9 facsimile =m & purports to come f ,uriel ,s4 ,boone1 ,m4,d41 ( ,/4 ,l\is1 :o /ates t he is 8prep>+ an exhau/ive article = publication 9 a lead+ m$ical j\rnal0 on ! "q1 8,is acetanilid a habit-=m+ drug80 ,to obta9 ! necess>y data ,dr4 ,boone is 8writ+ to e hospital & sanit>ium 9 ! ,unit$ ,/ates40 ,exam9ation ( ! "q blank :i* accompanies ! =m lett] discloses ! fact t in=mation is want$ reg>d+ n acetanilid alone1 b also antipyr9 & acetph5etid9 7ph5acet974 ,! la/ "q ask$ runs z foll[s3 8,if y\r records ( cases ( habitual use ( ^! drugs are incomplete1 w\ld y all[ a reputable physician to inve/igate ! above-m5tion$ cases s t he c\ld write ) positiv5ess ab\t !m1 &1 if necess>y1 make oa? to ! tru? ( 8 report80 ,italics ours4--,ed4 ,dr4 ,boone op9es t ! recipi5ts ( 8 qu]ies 8may hesitate to answ]0 ! "q j quot$1 b he tru/s t its importance w be evid5t :5 he expla9s t 8x is curr5tly report$ t ! manufactur]s ( acetanilid1 ph5acet91 etc41 h decid$ to prosecute all libel]s ( ^! drugs0 ,italics aga9 ours4--,ed4 & he wi%es to make no /atem5t t he 8c n sub/antiate "u oa?40 ,surely ! life ( ! collector ( m$ical /ati/ics is unusually haz>d\s4 ,= ! purpose ( aid+ ,dr4 ,boone 9 8 ardu\s se>* = tru? on ! 8mu* moot$ "q1 #8,is acetanilid a habit-=m+ drug8'0 we direct 8 att5tion to a "w t %\ld prove ( invaluable assi/ance4 ,we ref] to ,bullet9 #abf ( ! ,bureau ( ,*emi/ry1 entitl$ 8,! ,h>mful ,effects ( ,acetanilid1 ,antipyr9 & ,ph5acet940 ,?is int]e/+ /udy to :i* we h previ\sly call$ att5tion records #aab cases ( ! acetanilid habit4 ,( ?is numb] at lea/ #ej1 or #dd4f p] c5t4 ( ! cases 7 ^? ( pati5ts :o took propriet>y prep>ations ( ! drug4 ,f ?is we w\ld n wi% to give any bias to ,dr4 ,boone's /ati/ics4 ,we h>dly expect1 h[ev]1 t su* w be ! case4 ,dr4 ,boone's "n appe>s z ! au?or ( an article entitl$ 8,a ,!rapeutic ,/udy ( ,antikamnia & ,h]o9 ,tablets0--an article t has be5 v ext5sively 8quot$0 & has be5 s5t out 9 its entirety by ! ,antikamnia ,*emical ,company4 ,"u ^! circum/ances we may be =giv5 if we v5ture ! op9ion t ,dr4 ,boone is n likely to be unduly prejudic$ aga9/ 8heada*e tablets0 9 g5]al & fake 8syn!tic0 coal-t> mixtures 9 p>ticul>4 ,we await ) brea?less int]e/ ! appe>ance ( ,dr4 ,boone's 8exhau/ive article0 & we mu/ confess to "s degree ( curiosity reg>d+ ! "n ( ! 8lead+ m$ical j\rnal0 9 :i* ^! valuable data w appe>4--7,modifi$ f ,! ,j\rnal ,a4 ,m4 ,a41 ,aug4 #ad1 #aiji47 ,,hect9e ,hect9e is a ,fr5* propriet>y & is /at$ to be1 *emically1 sodium b5zosulphoam9o-ph5yl-ars5ate4 ,if ! ass]t$ composition is correct1 ,hect9e is simil> to atoxyl1 :i* is describ$ 9 ,new & ,non(ficial ,rem$ies1 #aiad1 page #ch4 ,hect9e has n be5 exam9$ by ! ,c\ncil on ,ph>macy & ,*emi/ry4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,aug4 #h1 #aiad47 ,,hydronaph?ol ,a correspond5t hav+ reque/$ in=mation reg>d+ ! composition ( 8,hydronaph?ol10 ! product 0 inve/igat$ 9 ! ,association laboratory1 :i* reports z foll[s3 ,hydronaph?ol is sold by ,seabury ,johnson4 ,! label on a trade package ( ,hydronaph?ol gives no clew z to ! nature ( ! product4 ,! /atem5ts on ! labels d1 h[ev]1 make ! claim t ,hydronaph?ol is an antiseptic ( great p[]1 also t x is non-toxic & !re=e may be us$ ) impunity2 ?us ! foll[+ /atem5ts are made3 8,a h>mless1 practically odorless1 non-poison\s1 non-corrosive antiseptic44440 8444 x is non-poison\s & c be employ$ ) p]fect immunity z a pres]vative44440 ,! sub/ance has ! *>act]i/ic appe>ance1 odor & ta/e ( naph?ol4 ,x respond$ to all ! te/s ( ! ,unit$ ,/ates ,ph>macopeia = betanaph?ol1 ) ! exception ( ! melt+ po9t1 :i* 0 f\nd to be #aai ,c4 in/ead ( #abb ,c41 an indication ( impurity4 ,x is evid5t1 !re=e1 t ,hydronaph?ol is m]ely a trade-"n = betanaph?ol4 ,:ile resublim$ betanaph?ol is li/$ at #aj c5ts an ounce1 ,hydronaph?ol is li/$ at #ge c5ts an ounce4 ,hydronaph?ol ?us furni%es "o m illu/ration ( ! fact t mo/ propriet>y m$ic9es = :i* ! mo/ extravagant claims are made are b old & well-kn[n rem$ies sold "u a fancy "n at a price f> 9 advance ( t *>g$ = ! con/itu5t or con/itu5ts4 ,! exploit]s are extremely positive 9 _! /atem5ts reg>d+ ! non-toxic "* ( ! prep>ation4 ,yet1 z a matt] ( fact1 betanaph?ol is by no means h>mless2 x has be5 absorb$ by ! diseas$ sk9 ) injury to ! kidney & ) fatal results4 ,9 "s cases injury to ! eye has also occurr$4 ,^! toxic actions %\ld be kn[n to ! practition]4 ,f #c to #d gm4 7#a dram7 appli$ to ! sk9 has produc$ dea? 7,/]n3 ,!rap4 ,monat%efte1 #aijj1 p4 #afe74 ,:5 a manufactur] adv]tises a prep>ation :i* possesses pot5tialities = h>m1 & especially :5 he puts x out "u a "n :i* conceals its id5tity1 x is incumb5t on him to w>n ! cu/om] ( possible injuri\s or inconv5i5t actions in/ead ( proclaim+ t ! prep>ation is h>mless4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,sept4 #c1 #aiaj47 ,,hydrozone ,! moral pr9ciple gov]n+ ! action ( secret propriet>y & pat5t m$ic9e m5 is an unkn[n quantity2 sometimes x w\ld seem to be a negative "o4 ,j h[ mu* l[] 9 ! scale ( humanity a man c g ?an to prey on ! fe>s ( a p 9 ! "t ( a t]rible epidemic = ! sake ( a few doll>s we d n "k4 ,!re may be some?+ m despicable1 b :at is x8 ,two weeks ago we ref]r$ to ! cold-blood$ me?ods ( ! ,p]una p2 ?is week we reproduce an adv]tisem5t f ! ,new ,orleans ,/ates t tells ano!r /ory ( man's inhumanity to man4 ,illu/ration ,?is br+s up ! problem t we are try+ to solve1 viz43 8,:at is ! diff]5ce betwe5 a #8secret propriet>y m$ic9e' adv]tis$ 9 m$ical j\rnals to physicians & a #8pat5t m$ic9e' adv]tis$ 9 newspap]s to ! public80 ,hydrozone is be+ adv]tis$ 9 ne>ly all m$ical j\rnals1 & at ! same "t 9 newspap]s4 ,:]e %all we place x8 ,& if hydrozone1 ) ! me?ods rec5tly adopt$ to exploit x1 is tol]at$ 9 ! m$ical press1 :y n p]una8 ,,hypoqu9idol ,an exam9ation ( ! adv]tis+ matt] fails to %[ t ,r4 ,w4 ,g>dn] makes any def9ite /atem5t 9 reg>d to ! nature or ! composition ( 8 ,hypo-,qu9idol4 ,c]ta9 /atem5ts made 9 ! lit]ature s\nd mu* z if ! article might be "s sort ( a qu99 hypophosphite prep>ation4 ,b if ?is is true1 its action w\ld be ! same z o!r salts ( qu99 & ! extravagant claims made c\ld n be sub/antiat$4 ,x is said to be a 8non-toxic qu9940 ,x is safe to say t a qu99 :i* w n produce ! toxic symptoms--c9*onism--ei!r is n absorb$ 9 suffici5t quantity or has be5 s *ang$ t x no long] has ! !rapeutic prop]ties ( qu994 ,altoge!r ,hypo-,qu9idol mu/ be put d[n z a prep>ation ! composition ( :i* is kept secret & reg>d+ :i* extravagant & highly improbable /atem5ts are made4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #aj1 #aiad47 ,,iodonucleoid ,an ,iod9 ,product ,"u a ,mislead+ ,"n ,in=mation has be5 frequ5tly ask$ conc]n+ ,iodonucleoid1 a product n includ$ 9 ,new & ,non(ficial ,rem$ies4 ,! ,association ,laboratory aft] inve/igat+ ?is prep>ation report$ z foll[s3 ,?is prep>ation 0 at "o "t consid]$ = inclusion ) ,new & ,non(ficial ,rem$ies1 & at t "t 0 exam9$ 9 ?is laboratory4 ,! exam9ation %[$ t iodonucleoid conta9s3 ,phosphorus #j4gi p] c5t4 ,calcium #j4dc p] c5t4 7,equal to #j4f p] c5t4 ,ca,o74 ,iod9 #bd4b p] c5t4 ,:5 #b gm4 0 dissolv$ 9 t5?-normal potassium hydroxid volumetric solution & acetic acid add$ until fa9tly acid1 an abundant1 :ite1 floccul5t precipitate =m$4 ,?is precipitate 0 collect$1 wa%$ ) wat]1 transf]r$ to a beak]1 ph5olph?ale9 add$ & t5?-normal potassium hydroxid volumetric solution run 9 until a p9k color 0 produc$4 ,?is requir$ #ae c4c4 ( t5?-normal alkali4 ,subtract+ f ! #b gm4 ( iodonucleoid ! #bd p] c5t4 iod91 leaves #a4eb gm42 ?is divid$ by ! c4c4 ( alkali us$ indicates an equival5t weight ( #ajac4 ,au?orities diff] widely reg>d+ ! am\nt ( phosphorus conta9$ 9 nucle9 f diff]5t s\rces1 ! figures rang+ f #b4i p] c5t4 to z high z #aj p] c5t4 ,if ! nucle9 f :i* iodonucleoid purports to be made conta9$ b #b4i p] c5t4 phosphorus1 ! prep>ation1 aft] all[+ = #bd p] c5t4 iod91 %\ld /ill conta9 #b4b p] c5t4 phosphorus in/ead ( ! #j4gi p] c5t4 f\nd by analysis4 ,a true nucle9 %\ld conta9 no calcium4 ,if iodonucleoid is a case9 comp\nd ( iod9 we might expect to f9d1 if ! case9 _h be5 fre$ f milk by acidulation )\t fur!r purification1 bo? calcium & phosphorus4 ,! equival5t weight ( case9 is giv5 by ,long 7,j\r4 ,am4 ,*em4 ,soc41 #aijf1 xxviii1 #cgb7 z #aabd4 ,?is figure 0 obta9$ on a case9 ( high purity1 & ! figure ( #ajac giv5 above agrees fairly well ) ,long's figure = case94 ,! evid5ce1 !re=e1 indicates t iodonucleoid is a comp\nd ( iod9 & case91 & n a nucle9 comp\nd4 ,! f9d+s ( ! laboratory 7 at t "t submitt$ to ,pr(4 ,john ,h4 ,long ( ,nor?we/]n ,univ]sity1 :o said3 8,we h also made a numb] ( exam9ations ( iodonucleoid4 ,we det]m9$ 9 x ! iod9 & f\nd ! am\nt #bd4b p] c5t4 by weight1 :i* is a little m ?an t claim$ by ! manufactur]4 ,we h also te/$ ! solubility ( ?is sub/ance & f9d x to behave ab\t z y\r laboratory did4 ,z y "k1 we h be5 mak+ a numb] ( prep>ations f case91 & rec5tly we h det]m9$ ! comb9+ p[] ( case9 ) v>i\s acids1 includ+ hydriodic acid4 ,?is acid :5 evaporat$ 9 mod]ately /rong solution ) case9 yields f9ally a h>d1 dry mass1 :i* may be gr\nd up to a p[d] resembl+ v closely ! prep>ation "u discussion4 ,v>i\s am\nts ( iod9 may be comb9$ "h1 dep5d+ on ! /r5g? ( ! iod9 solution us$1 & we h secur$ "s conta9+ ov] #ce p] c5t4 ( iod94 ,sev]al ( ^! prep>ations resemble closely iodonucleoid1 s f> z solubility1 appe>ance & reaction ) alkalies on titration are conc]n$4 ,i am unable1 !re=e1 to di/+ui% ?is prep>ation f ! case9 comp\nds :i* we are mak+40 ,f ?is x w\ld appe> t iodonucleoid is n a comp\nd ( nucle91 z indicat$ by ! "n1 b in/ead is a case9 comp\nd ( iod94 ,iodonucleoid1 !n1 seems to be ano!r "o ( ! _m iod9 8sub/itutes0 :i* h be5 put on ! m>ket4 ,o!r iod9 sub/itutes are ,iodalb91 manufactur$ by ,p>ke1 ,davis ,co42 ,iodip9 manufactur$ by ,e4 ,m]ck ,co41 & ,sajod91 manufactur$ by ! ,f>b5fabrik5 ( ,elb]feld ,co4 ,z ^! products h be5 exam9$ by ! ,c\ncil & f\nd eligible = inclusion ) ,new & ,non(ficial ,rem$ies1 physicians :o wi% to use sub/itutes = potassium iodid w\ld d well to use !m in/ead ( a product pres5t$ "u a mislead+ "n4 ,physicians %\ld und]/&1 h[ev]1 t ^! organic iod9 comp\nds are non-irritat+ because ! iod9 is held 9 su* comb9ation t x is mu* less active4 ,x seems probable t !y are !rapeutically active only to ! ext5t t ! iod9 cont5t is dissociat$ f ! organic comp\nd & conc]t$ into ionic iod94 ,a discussion ( a numb] ( iod9 sub/itutes is f\nd 9 an article by von ,not?afft 7,monat%4 f4 prakt4 ,d]mat41 ,oct4 #ae1 #aiaj1 p4 #cdc71 :i* 0 ab/ract$ & comm5t$ on 9 ,! ,j\rnal1 ,m>* #d1 #aiaa1 p4 #fhe4 ,von ,not?afft believes t ! l[] degree ( toxicity :i* ^! rem$ies exhibit has its basis 9 a feebl] activity2 ei!r ! sub/itutes evolve too little iod9 or !y split x (f ) great] difficulty4 ,physicians %\ld1 !re=e1 view ) "s di/ru/ ! claims ( manufactur]s t _! products are n only non-irritat+ b at ! same "t possess unusual !rapeutic effici5cy4 ,?is w apply ) especial =ce if !re is any t5d5cy to conceal ! nature or orig9 ( ! comb9ation4--7,! ,j\rnal ,a4 ,m4 ,a41 ,july #bb1 #aiaa47 ,,iridium ,dr4 ,c4 ,a4 ,dext]1 ,columbus1 ,ga41 asks = in=mation conc]n+ ! use ( iridium 9 ! treatm5t ( acute & *ronic rheumatism4 ,iridium is a well-kn[n elem5t al?\gh we h n f\nd t x has be5 us$ z a m$ic9e2 h[ev]1 we presume our correspond5t ref]s to 8,iridium 7,m$ic9al710 sold by ! ,plat9um ,company ( ,am]ica4 ,we are n able to locate ?is company1 b 9 _! adv]tis+ circul> 8,iridium 7,m$ic9al70 is said to be 8an ag5t = ! blood1 a laxative1 an alt]ative1 indicat$ 9 all disord]s ( ! /oma*1 9 ,jacksonian epilepsy10 & 8a specific 9 rheumatism40 ,z to its orig91 x is said 9 ! circul>1 8! plat9um s&s are associat$ ) & compos$ ( iridium0 & "s o!r elem5ts1 s t z f> z ! circul> gives in=mation ! no/rum is alleg$ to conta9 ! elem5t iridium4 ,a few /atem5ts quot$ f ! circul> w %[ t ! p]son :o wrote x kn[s no?+ ab\t m$ic9e & _c correctly use ! ,engli% language3 8,! qualifications ( ,m$ic9al ,iridium are its simplicity1 purity1 h>mless "u prolong$ use1 easily borne by ! /oma*40 8,x has be5 obs]v$ t :5 ,m$ic9al ,iridium acts z a laxative1 x w regulate ! same40 8,call$ ! family gr\p1 ,iridium & ,osmium are de/9$ to become ! _w's b5efactors 9 m$ic9al prop]ties1 !reby creat+ a new *apt] 9 m$ical sci5ce40 ,! circul> quotes "s suppos$ 8exc]pts f hundr$s ( lett]s on file1 writt5 by physicians1 9 ! hope t !y may attract y\r att5tion10 :i* be> m>ks ( hav+ be5 writt5 by ! same p]son :o wrote ! circul>4 ,note ! quality ( ! foll[+ /atem5ts3 8,iridium has a p[]1 purity & simplicity t pleases me2 n[ ,i c make progress40 8,i say to y frankly1 ,iridium is my /&>d4 ,i c get results & make progress4 ,i am confid5t x aids ! fibr9 9 ! blood40 8,dr4 ,x is pu%+ ,iridium on five or six cases40 ,x is n expla9$ :o ,dr4 ,x is1 b x has ?is to say ab\t him3 8,dr4 ,x is an em95t practition]4 ,he has made a rem>kable record ) ,iridium & has s f> nev] fail$ on cases ( ,jacksonian epilepsy2 exp]im5tal te/s h %[n t ,iridium increases blood-corpuscles40 ,! man :o signs himself presid5t ( ! ,plat9um ,company ( ,am]ica is said to be a lawy]1 b is n work+ at x1 & 0 =m]ly a promot]1 fiscal ag5t1 etc4 ,x %\ld n be difficult = ! physician to fix ! /atus ( iridium "u ?is sort ( exploitation4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,april #bc1 #aiaj47 ,,iron ,,tropon ,! composition ( ,iron ,tropon seems to h v>i$ f "t to "t4 ,! manufactur]s =m]ly /at$ t x conta9$ fat1 sug>1 peps9 & iron 9 organic comb9ation ) album91 & its use 0 advocat$ bo? z a food & z a m$ic9e4 ,x 0 n claim$ to conta9 ov] #a p] c5t4 ( peps91 b te/s fail$ to %[ t x conta9$ any peps91 or if any1 su* a small am\nt t !re 0 n suffici5t to dige/ ! album9 9 ,iron ,tropon itself4 ,x 0 also claim$ t ! iron1 be+ 9 organic comb9ation ) ! album91 possess$ advantages ov] ! widely us$ aromatic fluid prep>ations ( iron4 ,te/s1 h[ev]1 %[$ t ! iron 0 n 9 organic comb9ation1 ?\gh ev5 _h x be51 late inve/igations fail to demon/rate ! sup]iority ( ! organic ov] inorganic iron comp\nds4 ,! manufactur]s /ate 9 _! lat] 8lit]ature0 t ,iron ,tropon is a tonic & a food2 t x is a comp\nd ( ! food album9 tropon1 #b4e p] c5t4 ( iron 9 its mo/ assimilable =m1 & en\gh *ocolate to flavor x agreeably4 ,x w be not$ t !y n[ make no claim = peps91 nor d !y /ate t x conta9s iron 9 organic =m4 ,9 ! dose recomm5d$1 a teaspoonful ?ree times a day = an adult1 ! pati5t gets some?+ ov] a gra9 ( iron1 & he might z well take an equival5t quantity ( ,blaud's mass1 ! value ( :i* has be5 prov$4 ,z a food1 ,iron ,tropon1 weight = weight1 is ab\t equal to beans & a little bett] ?an fl\r1 al?\gh x conta9s a l>g] p]c5tage ( prote9 ?an ei!r4 ,9 ! dose /at$1 an invalid w\ld get ab\t #ej calories1 or ab\t #a_/dj ! necess>y n\ri%m5t = a day4 ,te/s h also %[n t ! album9 is difficult ( dige/ion4 ,9 spite ( ?is fact1 ! adv]tisem5t ( ,iron ,tropon /ates3 8,a pati5t :o takes ,iron ,tropon receives n only ! b5efit ( iron m$ication1 b at ! same "t 8 economy is suppli$ ) p]fectly assimilable album9 9 suffici5t quantity40 ,x w ?us be se5 t ! claim = peps9 9 ?is prep>ation has be5 ab&on$1 t ! /atem5t z to ! iron be+ 9 organic =m has be5 modifi$1 & t ! food value ( ! album9 is exagg]at$2 b p]haps ! manufactur]s d n expect ! physician to apply 8 ari?metic to su* problems4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,april #bc1 #aiaj47 ,,kutn[',s ,,p[d] ,:i* ,is ,x1 a 8,propriet>y0 or a 8,pat5t ,m$ic9e08 ,! t]m 8pat5t m$ic9e0 has be5 appli$1 r loosely1 to ^? no/rums sold & exploit$ directly to ! public1 :ile ! "n 8propriet>y0 has be5 giv5 su* prep>ations z are adv]tis$ only to ! m$ical pr(ession4 ,z has be5 _m times exemplifi$ by reports 9 ,! ,j\rnal1 ! di/9ction is (t5 a v f9e "o & ! divid+ l9e frequ5tly rea*es ! vani%+ po9t4 ,x is n unusual1 = in/ance1 = 8propriet>y0 prep>ations to be foi/$ on ! m$ical pr(ession until a c]ta9 numb] ( te/imonials 7( d\btful value1 x is true1 b /ill te/imonials7 h be5 +5i\sly :e$l$ out ( physicians & ! product r g5]\sly prescrib$4 ,:5 ?is objective po9t has be5 rea*$ ! manufactur] comes into ! op5 & adv]tises ! no/rum to ! public direct & ! te/imonials previ\sly giv5 = ! 8propriet>y0 are us$ z adv]tis+ assets = ! 8pat5t m$ic9e40 ,!n aga9 !re are c]ta9 prep>ations :i* are 8propriet>ies0 or 8pat5t m$ic9es0 accord+ to ! location4 ,on "o side ( ! ,atlantic ! product is adv]tis$ to physicians only1 :ile on ! o!r side x runs indiscrim9ately on ! billbo>ds & 9 ! newspap]s4 ,"o ( ! be/ examples ( ?is la/ class is ,kutn['s ,p[d]4 ,9 ,engl&1 :]e x orig9at$1 ?is prep>ation1 :i* 8dissolves & elim9ates uric acid10 is consi/5tly l9$ up ) ,bee*am's ,pills & ,p9k ,pills = ,pale ,p4 ,full-page newspap] adv]tisem5ts ann\nce ! fact t free samples w be ---------------------------- 8,,s5t ,,to ,,all ,,applicants0 ---------------------------- ,9 ! ,unit$ ,/ates1 h[ev]1 ,kutn['s h le>n$ f _! wide adv]tis+ exp]i5ce t a *eap] & sur] way ( introduc+ a no/rum to ! public is to adv]tise x to ! m$ical pr(ession only4 ,by means ( adv]tisem5ts 9 m$ical j\rnals 7^: space is mu* less exp5sive ?an t ( ! daily pap]s7 & ! lib]al di/ribution ( samples :i* are ---------------------------------- 8,,s5t ,,free ,,to ,,physicians ,,only0 ---------------------------------- ! m$ical pr(ession becomes ! unpaid 8b>k]0 = ! no/rum manufactur]4 ,at pres5t1 !re=e1 ,kutn['s ,p[d] is--9 ! ,unit$ ,/ates--an e?ical 767 8propriet>y40 ,illu/ration ,!re exi/s 9 ?is c\ntry1 z mo/ ( our read]s "k1 an organization ( 8pat5t m$ic9e0 manufactur]s ^: 8reason = be+0 is to get full value receiv$ = ! #dj1jjj1jjj paid annually 9 adv]tis+ no/rums 9 ! newspap]s ( ! c\ntry4 ,?is organization is kn[n z ! ,propriet>y ,association ( ,am]ica4 ,! n[ famili> 8r$ clause0 9 ! adv]tis+ contracts by :i* ! newspap] =feits its contract if /ate laws are enact$ t are inimical to ! 8pat5t m$ic9e0 int]e/s1 is a creation ( ?is organization & has be5 mo/ effective 9 mak+ ! newspap]s ! unpaid lobbyi/s ( ! no/rum int]e/s4 ,! 8sil5ce clause0 is ano!r 8jok]0 9 ! contracts by :i* ! agreem5t is cancel$ if matt] detrim5tal to ! no/rum 8is p]mitt$ to appe> 9 ! read+ columns0 ( ! pap]4 ,x is little wond] t ) su* weapons ! 8pat5t m$ic9e0 manufactur] has assum$ an arrogance t is z disgu/+ z x is s]i\s4 ,great ,brita91 too1 has its 8pat5t m$ic9e0 m5's organization1 :i* is kn[n z ! ,propriet>y ,articles ,trades ,association4 ,( bo? ^! honorable bodies ,mr4 ,s4 ,kutn[ ( ,kutn[ ,bro!rs1 ,ltd41 is1 or 01 a conspicu\s memb]4 ,at a rec5t meet+ ( ! ,briti% organization1 ,mr4 ,kutn[ work$ himself into a f9e fr5zy ( indignation because ( "s articles t _h appe>$ 9 ! ,ph>maceutical ,j\rnal ( ,london on ! subject ( 8,secret ,rem$ies & ,propriet>ies40 ,z ^! articles did n specifically m5tion ,kutn['s ,p[d]1 & z evid5ce 0 direct$ aga9/ only ^? prep>ations z 7 mo/ disreputable1 x is evid5t t ,mr4 ,kutn[ n[ appraises 8 own product at its face value4 ,he gave 8 op9ion ( ! ,ph>maceutical ,j\rnal & told ! meet+ t :5 ! adv]tis+ man = t j\rnal solicit$ adv]tis+ he refus$ to h any m deal+s ) him ow+ to ! articles t _h appe>$ 9 ! ,ph>maceutical ,j\rnal4 ,he decl>$ t he 0 q indep5d5t ( any newspap] or j\rnal1 & 0 able to take c>e ( himself4 ,!re9 ,mr4 ,kutn[ is mi/ak52 he is n indep5d5t ( newspap]s & j\rnals4 ,on ! contr>y1 he & o!rs ( 8 ilk are mo/ subs]vi5tly dep5d5t on !m4 ,let reputable pap]s & m$ical j\rnals refuse1 = b "o ye>1 to c>ry ! high-fl[n adv]tisem5ts ( 8 ,anglo-,am]ican ,pat5t-,propriet>y1 & 8 firm w\ld p]=ce seek "s wor?i]1 if less pr(itable1 l9e ( bus9ess4 ,! editor ( ! ,ph>maceutical ,j\rnal res5ts ,mr4 ,kutn['s 8impli$ assumption t by ins]t+ paid ann\ncem5ts 9 ! adv]tis+ columns ( a newspap]1 he or any "o else1 c dictate ! policy ( t organ40 ,! ,ph>maceutical ,j\rnal1 x %\ld be said1 is ! (ficial organ ( ! ,ph>maceutical ,society ( ,great ,brita91 & is ! mo/ influ5tial organ ( ! drug trade 9 ! ,briti% ,isles4 ,x is refre%+ to note1 9 ^! days ( 8cann$0 editorials & paid 8write-ups0 masqu]ad+ z orig9al articles1 t !re is /ill to be f\nd a j\rnal t c n be b\ght4 ,"o wond]s :e!r a l>ge exp]i5ce 9 ! adv]tis+ _w1 & especially 8 memb]%ip 9 ! ,propriet>y ,association ( ,am]ica1 has unconsci\sly l$ ,mr4 ,kutn[ to assume t muzzl+ ! press is "o ( ! p]quisites ( ! l>ge pur*as]s ( adv]tis+ space4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,aug4 #ca1 #aijg47 ,,lymph ,,comp\nd ,r-,h ,,& ,,or*itic ,,fluid ,,tablets ,a physician wrote ,! ,j\rnal3 8,i h "u my c>e a pati5t ) *ronic p>5*ymat\s nephritis4 ,microscopic exam9ation %[s occasional epi!lial ca/s1 ) hyal9e & granul> ca/s4 ,! pati5t feels well & appe>s to enjoy ! be/ ( heal?4 ,please give me y\r op9ion on ! use1 9 su* a case1 ( ! lymph injections put out by ! ,animal ,!rapy ,company ( ,*icago1 f :om ,i h j receiv$ a supply ( lit]ature40 ,! ,j\rnal repli$ z foll[s3 8,! ,c\ncil on ,ph>macy & ,*emi/ry took up = consid]ation ! #8,lymph ,comp\nd ,r-,h1' & #8,or*itic ,fluid ,tablets1' sold by ! ,animal ,!rapy ,company & refus$ !m recognition4 8,! treatm5t ( a case ( *ronic p>5*ymat\s nephritis is a task requir+ ! be/ judgm5t & ! greate/ k t ! physician c comm&4 ,f ! fir/ 8 aim %\ld be to d no h>m1 & ) ?is 9 view he w recognize t s9ce we d n "k ! cause ( ?is disease1 & s9ce we are unable to influ5ce ! ess5tial process 9 ! kidney1 ! adm9i/ration ( a rem$y capable ( do+ h>m %\ld be und]tak5 only "u ! cle>e/ indications4 ,x is probable t ! rem$y propos$1 conta9+1 x is ass]t$1 a mixture ( =eign prote9s1 might injure heal?y kidneys1 to say no?+ ( sick ones4 ,x is well kn[n t =eign prote9s1 su* z ! :ite ( egg1 if !y ent] ! circulation un*ang$1 are excret$ by ! kidney & are liable to produce s]i\s irritation1 :i* 9 ! case ( p>5*ymat\s nephritis might easily aggravate ! exi/+ condition & fru/rate all o!r ef=ts at a cure4 ,m especially is x imp]ative to d no h>m :51 z 9 ! case report$ by our correspond5t1 ! pati5t appe>s to be 9 good heal?4 ,two que/ions %\ld be rais$ 9 t case4 ,fir/1 is !re any evid5ce t ! occasional excretion ( a few ca/s1 :atev] may be _! v>iety1 is actually do+ ! pati5t any h>m8 ,& second1 s9ce !re are no symptoms1 :at possible improvem5t c\ld be expect$ f treatm5t8 ,x is admitt$ t we h no rem$y :i* c affect an ess5tial *ange 9 ! condition ( ! diseas$ kidney4 ,:at mu/ be done 9 su* a case is to sp>e ! kidney--to require ( x ! m9imum ( functional activity4 ,9 su* a case1 ! physician :o introduces an animal prote91 =eign to ! human sy/em1 w\ld be tak+ a s]i\s responsibility4 ,! *ances are t x w\ld d h>m2 h[ great1 no "o c tell4 ,if ! physician c really make up 8 m9d to exp]im5t at ! risk ( ! life ( 8 pati5t1 ?is case appe>s to be "o unusually favorable to ! manufactur] ( ! s]um4 ,!re are *ances t ! diagnosis may be incorrect & t su* a condition ( ! ur9e does n indicate a s]i\s condition ( ! kidney4 ,x is frequ5tly ! case aft] an acute infection1 or "s simil> irritation1 t ! kidney cont9ues = "s "t to excrete album9 & ca/s1 b ! condition ev5tually cle>s up4 ,9 su* a case1 if ! s]um did no h>m x w\ld be giv5 ! cr$it ( cur+ ! pati5t1 :o recov]s 9 spite ( x4 ,x is a little un=tunate1 h[ev]1 = ! purpose ( su* demon/ration t ! pati5t is said to feel well4 ,if only he c\ld be p]suad$ t he has a s]i\s disease s t he might be some:at depress$ m5tally1 ! effect ( ! cure w\ld be m rem>kable6 8,if ! physician to :om su* a pati5t comes = advice1 in/ead ( tak+ ! wise c\rse ( seek+ reliable in=mation1 7 to take at _! face value ! /atem5ts ( int]e/$ comm]cial manufactur]s--if he 7 to adm9i/] ?is unkn[n & dang]\s rem$y1 ! effects ( :i* he _c pr$ict--he w\ld commit a brea* ( tru/ m culpable ?an ! mo/ vici\s attempts ( ! no/rum-mak] to mislead ! physician & ! public40--7,f ! ,j\rnal ,a4 ,m4 ,a41 ,dec4 #ad1 #aiab47 ,,lysol-,,! ,,evolution ,,( ,a ,,propriet>y ,reg>d+ c]ta9 propriet>y prep>ations & _! equival5ts f\nd 9 ! ph>macopeias or o!r /&>d works ( ref]5ce1 x is (t5 que/ion$ :e!r ! propriet>y is ! orig9al & ! (ficial prep>ation ! imitation1 or vice v]sa4 ,z a g5]al proposition1 m$ic9al comp\nds & prep>ations are n born b evolv$1 z 9 ! case ( ep9ephr91 9 :i* ! cr$it ( discov]y belongs to no "o p]son1 b to sev]al4#ajh ,s x is (t5 ! case t ! propriet>y & (ficial prep>ations may be bas$ "o on ! o!r1 :ile bo? are usually bas$ on "s prep>ation :i* ant$ates !m4 ,?is is well illu/rat$ by ! propriet>y prep>ation ,lysol1 ! practical equival5t ( :i*--liquor cresolis compositus--is (ficial 9 ! ,unit$ ,/ates ,ph>macopeia4 ,aft] ! discov]y ( ph5ol 7c>bolic acid7 & ! recognition ( its g]micidal value1 x 0 gradually le>n$ t o!r ph5olic comp\nds occurr+ 9 ! crude di/illates f t> & wood 7 m effici5t & less poison\s ?an ph5ol 7c>bolic acid74 ,:5 ?is 0 discov]$1 attempts ( c\rse 7 made to utilize ^! high] & m effici5t ph5ols1 :i* meant t _! insolubility 9 wat] _h to be ov]come4 ,9 ^! attempts !re 7 ef=ts to =m new comp\nds z well z a se>* = simple solv5ts4 ,:ile ! fir/ fail$1 because ^! comp\nds 7 less effici5t ?an ! ph5ol f :i* !y 7 made1 a simple solv5t 0 f\nd 9 soap4 ,! fir/ attempt to utilize ! solv5t p[] ( soap gave creol91 a mixture ( ! s-call$ crude c>bolic acid 7really conta9+ b little ph5ol & consi/+ l>gely ( high] ph5ols along ) in]t hydroc>bons7 ) soap4 ,?is 0 foll[$ 9 #ahhd by ,s*5kel's discov]y t a portion ( ?is 8crude c>bolic acid0 c\ld be made soluble 9 wat] by treatm5t ) soap4 ,s*5kel 0 refus$ a pat5t on ! gr\nd t any soap manufactur] %\ld be p]mitt$ to add ph5ol to 8 soap1 b 9 #ahhi a pat5t = a cresol-soap solution 0 grant$ to ,damann1 :o us$ cresol1 a con/itu5t ( 8crude c>bolic acid40 ,! prep>ation 0 put on ! m>ket & has s9ce be5 widely adv]tis$ "u ! propriet>y "n 8,lysol40#aji ,x is ?us se5 t ,lysol is a good example ( ! way 9 :i* manufactur]s appropriate ! discov]ies ( o!rs1 develop !m & turn !m to propriet>y use4 #ajh ,! ,j\rnal ,a4 ,m4 ,a41 ,m>* #be1 #aiaa1 pp4 #ija1 #iaj4 #aji ,ph>m4 ,ztg41 ,oct4 #ad1 #aijh1 p4 #hag4 ,! ill-des]v$ pat5t protection = ,lysol happily expir$ long ago & ! product c n[ be made by anyone4 ,9 view ( ! non-descriptive "* ( ! "n 8,lysol0 & ! dang] 9 us+ su* names 9 connection ) pot5t & poison\s rem$ies1 ?is cresol-soap solution has be5 admitt$ to ph>macopeias1 n "u ! orig9al "n 8,lysol10 b "u descriptive names su* z t 9 ! ,unit$ ,/ates ,ph>macopeia--8liquor cresolis compositus40--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,dec4 #ad1 #aiab47 ,,?ompson',s ,,malt$ ,,food ,,company ,& ,its ,blood1 ,n]ve & ,tissue ,build]1 8,hemo0 ,dur+ ! pa/ eighte5 mon?s ,! ,j\rnal has receiv$ inquiries f physicians 9 v>i\s p>ts ( ! c\ntry ask+ = in=mation reg>d+ 8,?ompson's ,malt$ ,food ,company0 ( ,wauke%a1 ,wis41 :i* = "s "t has be5 sell+ & try+ to sell its /ock to physicians & o!rs4 ,9 reply ,! ,j\rnal call$ att5tion to ! fallacy ( any conc]n try+ to induce p to pur*ase its /ock on ! gr\nd t ! ,bromo-,seltz] company1 ! ,po/um ,c]eal company & o!rs _h be5 successful4 ,illu/ration3 ,a m9iature reproduction ( a full-page adv]tisem5t ( 8,hemo0 appe>+ 9 a ,milwaukee pap]4 ,! orig9al cov]$ #cda squ>e in*es4 ,! e>li] "n = ! ,?ompson conc]n 0 8,am]ican ,malt$ ,food ,company0 & orig9ally x _h its (fice & factory 9 ,milwaukee4 ,its products are 8,malt$ ,milk10 8,malt$ ,beef-,peptone0 & 8,hemo40 ,z long ago z #aiaa ! company 0 s5d+ out gl[+ descriptions ( ! money t might be expect$ to be made by inve/+ 9 ! conc]n1 :i* 0 !n kn[n z ! ,am]ican ,malt$ ,food ,company4 ,accord+ to ! company's booklet x 0 e/imat$ t 9 ! ,unit$ ,/ates & ,canada alone #bj1jjj1jjj wor? ( dry malt food products 7 consum$ annually4 ,fur!r3 8,on ! mo/ cons]v+ e/imate ! ,am]ican ,malt$ ,food ,company w supply #e p] c5t4 ( ! dem& or #a1jjj1jjj ( ! consumption f ! v outset44440 ,at ! "t ?is 0 writt5 7#aiaa7 ! company claim$ t its /ock _h 8be5 advanc$ ov] #ajj p] c5t4 9 "o ye>'s "t0 & t ev5 !n x _h 8f\nd x advisable to curtail ! sale ( /ock s z n to exce$ ! prescrib$ numb] ( %>es to any "o p]son40 ,9 #aiad1 h[ev]1 ! company /ill _h its repres5tatives 9 ! field (f]+ /ock = sale4 ,9 ,novemb]1 #aiac1 "o physician wrote t ?ree ye>s previ\sly he _h pur*as$ /ock 9 ! company & at t "t 7#aiaj7 0 giv5 to und]/& t divid5ds w\ld be paid 9 at lea/ a ye>6 ,he has receiv$ no divid5ds to date4 ,o!r physicians h writt5 t ! company's ag5ts 9 attempt+ to sell /ock h giv5 ! impression t ! conc]n ei!r is pay+ divid5ds or is ab\t to pay divid5ds4 ,/ill o!r physicians say t ! ag5ts made no claim to !m t ! conc]n 0 pay+ divid5ds4 ,to quote f a few ( _m lett]s toge!r ) ! date ( ! communications3 8,allur+ promises ( big pr(its 9 ! ne> future h be5 held out by ! canvass]s44440 7,septemb]1 #aiac74 8,no actual promise 0 made b x 0 #8e/imat$' t divid5ds w\ld be decl>$ #8ab\t ! fir/ ( ! ye>'0 7,novemb]1 #aiac74 8,aft] ,i said ,i w\ldn't buy any /ock 0 told ! company 0 already pay+ divid5ds & ,i 0 turn+ d[n a good ?+40 7,m>*1 #aiad74 8,! ag5t gave me to und]/& t ! pr(its ( ! company 7 enorm\s & t l>ge divid5ds w\ld be paid 9 ! ne> future40 7,m>*1 #aiad74 8,mr4 ---- ! ag5t told me ! company expect$ to pay divid5ds z soon z all ! /ock _h be5 sold40 7,may1 #aiad47 8,! ag5t gave me to und]/& t !y 7 ab\t to pay v g5]\s divid5ds & t x 0 a *ance to get 9 on ! gr\nd floor on a good ?+40 7,may1 #aiad74 ,! price ask$ = /ock dur+ ! pa/ ye> or m has be5 #a4ej a %>e1 ! p> value ( ! /ock be+ held at #a4jj4 ,at v>i\s times1 h[ev]1 ! /ock seems to h be5 pur*asable f o!r s\rces at a mu* l[] figure4 ,a physician writ+ ,septemb]1 #aiac1 /at$ t he _h j be5 solicit$ to pur*ase /ock 9 ! ,?ompson ,malt$ ,food ,company at #a4ej a %>e1 & t imm$iately he wrote to two firms1 "o 9 ,*icago & "o 9 ,milwaukee1 t sell unli/$ securities1 ask+ ! price ( ,?ompson's ,malt$ ,food ,company /ock4 ,bo? brok]s express$ ! op9ion1 accord+ to ! physician1 t at #ij c5ts a %>e ! /ock w\ld be a 8good buy10 & bo? (f]$ to und]take to secure /ock at t price4 ,"o ( ! conc]ns s5t a circul> to ! physician (f]+ ! /ock at #hj c5ts4 ,! physician !reon cancel$ 8 ord] = /ock :i* he _h made at #a4ej & decl>$ t if he b\ght at all he w\ld buy f o!r s\rces4 ,,hemo ,at ! pres5t "t ! product t ,?ompson's ,malt$ ,food ,company seems to be 8pu%+0 is a product x calls 8,hemo40 ,accord+ to adv]tisem5ts1 ,hemo is 8! food t builds up weak /oma*s40 ,hemo1 we are told1 conta9s 8! iron ( sp9a*1 ! juices ( prime beef1 ! tonic prop]ties ( select$ malt 9 p[d]$ =m & ! ri*e/ sweet milk40 ,fur!rmore1 8,hemo conta9s ! active pr9ciple ( select$ b>ley malt 4440--:atev] ! 8active pr9ciple0 ( b>ley malt may be4 ,accord+ to ! ,?ompson ,malt$ ,food ,company 8#hj p] c5t4 ( ! ,am]ican citiz5s0 are 8tr\bl$ ) anemia0 & x is = !m t 8,hemo has be5 especially prep>$40 ,9 a s5t5ce3 8,x is a well-kn[n fact t organic iron c be obta9$ f animal life z well z f vegetable life1 & z ! dige/ive organs ( a majority ( ! p are n equal to ! task ( supply+ _! bodies ) a suffici5t am\nt ( organic iron to ma9ta9 a supply ( a good quality blood1 ! lack ( :i* results 9 num]\s n]v\s ailm5ts--insomnia1 diabetes1 rheumatism1 anemia1 tub]culosis1 etc41 x has be5 f\nd necess>y to secure = mank9d organic iron 9 a =m t w be conc5trat$1 palatable & mo/ easily assimilat$40 ,?is is a sample ( ! f>rago ( pseudo-sci5tific nons5se s5t out by ?is conc]n 9 its attempt to sell 8,hemo40 ,to cont9ue ! quotation3 8,) ?is object 9 view1 ! laboratories ( ,?ompson's ,malt$ ,food ,company h successfully produc$ & successfully tri$ out ,hemo on ! mo/ desp]ate cases40 ,9 a lett] address$ to a physician-/ockhold]1 ! /atem5t is made3 8,our ,hemo-,malt$ ,milk has nev] _h & nev] w h an equal z a build] ( blood1 n]ve & tissue 444 x w build tissue1 n]ve & blood 9 less "t ?an any o!r food h]et(ore kn[n40 ,disreg>d+ ! "q :e!r or n ?is is a /ock jobb+ s*eme or :e!r ! pur*ase ( ! /ock is a good inve/m5t1 !re is ano!r side to ! matt]4 ,x mu/ be evid5t t ! public is n gett+ a squ>e deal :5 physicians are f9ancially int]e/$ 9 ! products !y prescribe =1 or recomm5d to1 ! sick4 ,:atev] ! value ( ! ,?ompson products1 ! me?od ( exploitation & ! attempts on ! "p ( ! company to get physicians f9ancially int]e/$ 9 its v5tures1 are to be deprecat$4 ,if laym5 ( a speculative turn ( m9d wi% to inve/ 9 ! /ock ( companies putt+ out 8bottl$ en]gy10 8blood build]s0 & 8n]ve repair]s0 t is _! bus9ess1 b x is c]ta9ly nei!r conducive to ! sci5tific practice ( m$ic9e nor to ! int]e/ ( ! public = physicians to be f9ancially int]e/$ 9 products ( ?is sort4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,oct4 #bd1 #aiad47 ,,manola ,physicians z ,unpaid ,p$l]s ( ,no/rums ,"o ( ! mo/ di%e>t5+ features ( ! fight aga9/ ! propriet>y evil )9 ! pr(ession is ! sl[ness ) :i* physicians awake to _! responsibilities 9 ! matt]4 ,x is a notori\s fact1 famili> to physicians aga9/ adv]tis+ m5 alike1 t ! simple/ & *eape/ way to introduce a no/rum to ! public is ?r\gh ! in/rum5tality ( ! m$ical pr(ession4 ,ev] s9ce ! bir? ( ! propriet>y evil 9 ?is c\ntry1 %rewd manufactur]s h p]suad$ doctors to act z unpaid p$l]s = _! wret*$ no/rums & to become p>ticeps crim9is 9 ! exploitation ( su* w>es4 ,manola is an alcoholic no/rum ) j en\gh m or less in]t m$ic9al products add$ to exempt x f ! int]nal rev5ue tax1 b n en\gh to prev5t its be+ us$ z a tipple by ^? :o object to tak+ _! 8toddy0 9 a simpl] =m4 ,x is prep>$ by ! ,luyties ,ph>macy ,company ( ,/4 ,l\is1 a homeopa?ic conc]n ^: hahnemannian lean+s are n s /rong b t x is will+ to cat] to ! v>i\s sect>ian s*ools ( m$ic9e z well z to ! regul> pr(ession4 ,s9ce ! promot]s realize1 d\btless1 t to put ?is /uff out "u a homeopa?ic label might n be conducive to /imulat+ physicians' confid5ce1 ,manola is label$3 8,prep>$ only by ! ,manola ,company1 ,/4 ,l\is40 ,9 o!r words1 x is ! old dodge ( =m+ subsidi>y companies = ! purpose ( hid+ ! id5tity ( ! real own]s4 ,9 ?is connection1 x is wor? rem9d+ our read]s1 incid5tally1 t ! ,walk] ,ph>macal ,company1 ,/4 ,l\is1 is ano!r subsidi>y conc]n ( ! ,luyties ,ph>macy ,company1 creat$ = ! purpose ( pu%+ ano!r no/rum--,hymosa4 ,manola is seldom adv]tis$ 9 m$ical j\rnals4 ,in/ead ! ,luyties ,ph>macy ,company has discov]$ a m effective me?od ( 8putt+ "o ov]0 on physicians & druggi/s4 ,! me?od :i* has be5 pursu$ = ye>s & :i*1 "u ! same title & subtitle t head ?is article1 0 expos$ 9 ,! ,j\rnal z long ago z ,may #f1 #aije1 consi/s 9 s5d+ to physicians a lett] conta9+ ?ree po/c>ds--un/amp$1 ( c\rse4 ,) ! po/c>d !re is a slip t reads3 ,,in/ruction ,,= ,,obta9+ #c ,,bottles ,,( ,,manola ,,free ,de> ,doctor3 ,fill out ! atta*$ c>ds ,nos4 #a & #b4 ,mail ,no4 #a to u & h& ,nos4 #b & #c to y\r druggi/4 ,impress ^u him ! necessity ( mail+ po/al c>d ,no4 #c direct to u1 & n to 8 jobb]4 ,y\rs truly1 ,,! ,,manola ,,company4 ,! po/c>ds are numb]$1 respectively1 #a1 #b & #c4 ,"h is ,no4 #a3 ,illu/ration3 ---------------------------------------- ------------- #a ,mail ,?is ,c>d to ! ,manola ,co41 ,/ ,l\is1 ,mo4 ,date #ai ,,! ,,manola ,,company ,/4 ,l\is1 ,mo4 ,g5tlem53 ,i h reque/$ ,mr4 druggi/1 to ord] "o doz5 bottles ( ,,manola = my prescription4 ,please include ) 8 ord] ?ree bottles = me1 z p] y\r (f]4 ,,dr4 ,,*icago ,,ill4 ---------------------------------------- ------------- ,dr ,ezym>k writes ! "n ( 8 druggi/ on ,c>d #a1 puts a /amp on x & mails x to ! ,manola ,company1 alias ,luyties ,ph>macy ,co4 ,c>d #b1 address$ to 8 druggi/1 also is fill$ out by ,dr4 ,ezym>k4 ,"h x is3 ,illu/ration3 ---------------------------------------- ------------- #b ,please ,h& ,?is ,c>d to ,y\r ,druggi/ ,mr4 ,druggi/4 ,please ord] ( ! ,manola ,company1 ,/4 ,l\is1 ,mo41 #a doz5 bottles ( ,manola1 all ( :i* ,i agree to prescribe 9 my practice4 ,by fill+ out c>d ,no4 #c & =w>d+ x to ! ,manola ,company1 ,/4 ,l\is1 ,mo41 !y w include = me1 ) y\r ord]1 ?ree bottles ( ,manola1 free1 = cl9ical purposes4 ,y\rs truly1 ,m4,d4 ,t[n ---------------------------------------- ------------- ,!n ! doctor1 act+ ! "p ( err&-boy1 deliv]s ,c>d #b & also ,c>d #c to 8 druggi/4 ,"h is ,c>d #c3 ,illu/ration3 ---------------------------------------- ------------- #c ,,please ,,fill ,,out ,,& ,,mail ,,?is ,,c>d ,,to ,,! ,,manola ,,co41 ,,/4,,l\is1 ,,mo41 ,,n ,,to ,,y\r ,,jobb] ,date #ai ,,! ,,manola ,,company1 ,/4 ,l\is1 ,mo41 ,g5tlem53 ,please %ip me_/u z p] y\r (f] #a ,,doz5 manola ,,at #h4jj p] doz54 #a_/d doz5 ,,manola1 free1 = ,dr4 ,%ip ?r\gh my jobb]3 ,m ,sign$ ,druggi/4 ,t[n ,t[n ,/ate ,/ate ---------------------------------------- ------------- ,?is1 ,mr4 ,goat1 ! druggi/1 has to fill out1 affix a /amp & s5d to ! ,manola ,company4 ,9 return = all ?is1 ,mr4 ,goat has 8 %elves load$ up ) a doz5 bottles ( ,manola &1 = t privilege pays #h out ( 8 own pocket4 ,dr4 ,ezym>k gets ?ree free bottles4 ,incid5tally1 he also gets ! contempt ( 8 druggi/--& ( su* pati5ts z le>n ( x4 ,! only "o :o pr(its by all ?is is ! ,luyties ,ph>macy ,co41 alias ! ,manola ,co41 alias ! ,walk] ,ph>macal ,company4 ,evid5tly ?is me?od ( exploitation pays2 t x does pay is a disgrace to ! m$ical pr(ession4 ,to ^? physicians :o h 9 ! pa/ act$ z p$l]s = ,manola we w\ld say3 ,if y\r pati5ts really ne$ %]ry w9e let !m pur*ase x "u its own "n & at ! ord9>y m>ket price4 ,y w !n "k :at !y are gett+ & y w be able to reta9 n only y\r own self-respect b also ! respect ( y\r druggi/ & ! public4 ,! ,composition ( ,manola ,exam9ation ( ,manola 9 ! ,association laboratory indicates t its composition is consi/5t ) its orig91 = its m$ic9al +r$i5ts are pres5t 9 truly homeopa?ic quantities4 ,! laboratory report foll[s3 ,an exam9ation ( an orig9al bottle ( ,manola gave ! foll[+ results3 ,specific gravity at #be ,c4 #a4jcbi ,alcohol #ah4jj p] c5t4 by vol4 ,non-volatile matt] 7residue on evaporation7 #ae4ic gm4 9 #ajj c4c4 ,a% 4#if gm4 9 #ajj c4c4 ,phosphoric p5toxid 7,p#b,o#e7 4#jffh gm4 9 #ajj c4c4 ,total alkaloids 4#jjdg gm4 9 #ajj c4c4 ,calcium ,traces4 ,magnesium ,traces4 ,iron ,traces4 ,sodium ,traces4 ,ars5ic ,traces4 ,manola is a light amb] color$ liquid hav+ ! odor & ta/e ( %]ry w9e4 ,! above analysis indicates t x is no?+ m ?an w9e1 =tifi$ ) alcohol & a slight am\nt ( m$ic9al sub/ances add$4 ,! non-volatile matt] appe>s to be ne>ly all sug>1 glyc]91 or "s simil> sub/ance & ! pres5ce ( less ?an "o gram ( a% to #ajj c4c4 excludes ! pres5ce ( m ?an a small am\nt ( organic salts4 ,f ! am\nt ( phosphorus f\nd !re appe>s to be ab\t "o dose ( phosphoric acid to a tw5ty-ounce bottle4 ,ars5ic is pres5t 9 su* small am\nts t ! ord9>y hydrog5 sulphid te/ fail$ to %[ its pres5ce & ! delicate ,gutzeit's te/ _h to be us$ to detect x4--7,modifi$ f ,! ,j\rnal ,a4 ,m4 ,a41 ,april #b1 #aiaj47 ,,m]col ,r4 ,hunt & ,a4 ,seidell1 ,wa%+ton1 ,d4 ,c41 report ! result ( an exam9ation ( a prep>ation call$ ,h[ell's ,m]col1 manufactur$ by ,h4 ,b4 ,h[ell ,co41 ,ltd41 ,new ,orleans1 & claim$ to be a #a p] c5t4 solution ( m]curic iodid 9 a non-irritat+ neutral m5/ruum1 & recomm5d$ = hypod]mic use 9 ! treatm5t ( syphilis4 ,_! exam9ation indicates1 z !y say1 8t al?\gh ! manufactur]s ( ,m]col may h us$ a m]curic iodid 9 its prep>ation1 !y h n succe$$ 9 obta9+ a #a p] c5t4 solution ( ?is comp\nd 9 _! #8non-irritat+ neutral m5/ruum4' ,x is fur!rmore evid5t t ! sample exam9$ z above outl9$ conta9s none1 or at mo/ only traces1 ( b9iodid ( m]cury40 ,x is /at+ x mildly to say t a manufactur] is c>eless :o claims to make an effici5t prep>ation ( :at is almo/ a specific = "o ( ! mo/ s]i\s ( diseases b :i* conta9s practically none ( ! ess5tial active +r$i5t4--7,ab/ract$ f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #af1 #aiji47 ,! ,compon5t ,p>ts & ! ,f9i%$ ,product ,aft] ! appe>ance ( ! fir/ article1 a physician wrote /at+ he _h se5 ,m]col manufactur$1 foll[+ ! process 9 detail & _h himself weigh$ out a suffici5t quantity ( m]curic iodid to produce a #a p] c5t4 solution4 ,he prote/$ t ! firm 8_h no desire to foi/ on ! m$ical pr(ession or ! public a fraud40 ,) 8 lett] he s5t a sample ( ! p>ticul> bat* ( ,m]col :i* he _h se5 manufactur$4 ,?is sample 0 analyz$ ) ! same c>e & ?or\ghness t ! previ\s sample _h be51 & ! practical abs5ce ( m]curic iodid 0 aga9 demon/rat$4 ,:ile ,! ,j\rnal does n "q ! hone/y & good fai? ( ei!r ! manufactur]s or ! physician1 x ma9ta9s t claims = rem$ial ag5t %\ld be bas$ on ! f9i%$ product r ?an on ! compon5t p>ts us$ 9 its manufacture4 ,)\t attempt+ to expla9 :at has become ( ! m]curic iodid1 x insi/s t ! important fact1 & ! "o t vitally conc]ns bo? pati5t & physician1 is t ! f9i%$ product fails to conta9 x4 ,if ! manufactur] has made an hone/ mi/ake 9 suppos+ he c\ld produce a #a p] c5t4 solution ( m]curic iodid 9 liquid petrolatum1 he w d\btless see t ! mi/ake is correct$4 ,if1 on ! o!r h&1 he is gov]n$ by comm]cial consid]ations only1 ! misrepres5tation w probably be p]petuat$4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,may #ae1 #aiji47 ,,midol ,,& ,,nurito ,pyramidon ,ent]+ ! ,pat5t-,m$ic9e ,field ,repeat$ w>n+s to ! public ( ! dang]s ( acetanilid1 antipyr9 & acetph5etid9 & ! requirem5t 9 ! ,food & ,drugs ,act :i* makes x obligatory to decl>e ! pres5ce ( acetanilid & acetph5etid9 on ! labels ( 8pat5t m$ic9es10 h be5 responsible = ! gr[+ unpopul>ity ( no/rums conta9+ ^! drugs4 ,,midol ,dur+ ! pa/ few mon?s adv]tisem5ts h appe>$ 9 ! newspap]s ( a new 8heada*e cure10 ! adv]tis+ slogan ( :i* is t x 8conta9s no acetanilid or ph5acet940 ,! "n ( ?is prep>ation is ,midol & x is sold "u ! foll[+ claims3 8,in/antly relieves heada*e1 neuralgia1 too?a*e40 8,has no depress+ effect40 8,m effective ?an antipyr91 acetanilid1 ph5acet9 or simil> pa9-reliev+ products40 8,midol is ! "o safe-to-take aid ( suff]]s ( heada*e40 8,quickly relieves pa9 ( :atev] nature40 8,!re is no cumulative action40 8,no bad effect ^u ! he>t or o!r organs40 ,an orig9al package ( ,midol 0 pur*as$ & exam9$ 9 ! ,association laboratory4 ,! *emi/s' report foll[s3 8,midol is sold 9 ! =m ( :ite tablets ea* weigh+1 on an av]age1 #j4dbe gm4 or ab\t six & "o-half gra9s4 ,! tablets are soluble 9 wat]1 *lor(orm or b5z5e to ! ext5t ( ab\t #hj p] c5t4 ,! soluble portion appe>$ to be l>gely compos$ ( />*1 ) ab\t #d4e p] c5t4 ( "s inorganic matt]1 probably talc4 ,! *lor(orm soluble portion 0 f\nd to consi/ *iefly ( pyramidon1 *emically kn[n z dime?yl-dime?ylam9o-pyrazolon4 ,besides pyramidon1 ! *lor(orm soluble matt] conta9$ a small quantity ( caffe9 & may h conta9$ small am\nts ( o!r sub/ances4 8,f exam9ation x is conclud$ t ,midol dep5ds ess5tially on pyramidon = its !rapeutic effect40 ,pyramidon is a propriet>y prep>ation d]iv$ f1 & hav+ ! antipyretic & anodyne prop]ties (1 antipyr94 ,:ile "s obs]v]s h ass]t$ t x is m likely to cause collapse ?an are ei!r antipyr9 or acetph5etid9 !re is no positive evid5ce ( ?is ass]tion4 ,t ! use ( pyramidon has be5 until rec5tly practically re/rict$ to physicians may acc\nt = ! fact t its toxic effects are n z well kn[n z are ^? ( antipyr91 acetph5etid91 acetanilid1 etc41 :i* = "s ye>s h be5 indiscrim9ately us$ by ! public4 ,z ! use ( pyramidon z a 8pat5t m$ic9e0 n[ bids fair to become z g5]al z ! bett] kn[n antipyretics1 x is probable t its toxicology w become bett] kn[n4 ,x is int]e/+ to note t pyramidon 9 ! =m ( ,midol is put on ! ,am]ican m>ket by ! ,g5]al ,drug ,company1 :i* also acts z a di/ributor ( salv>san 78#fjf074 ,! ,g5]al ,drug ,company is said to h = its presid5t1 ,w4 ,m4 ,hoge1 :o 0 =m]ly employ$ 9 ! comptroll]'s (fice dur+ ! adm9i/ration ( ,h]man ,a4 ,metz1 & ! latt] be+ employ$ by ! ,consolidat$ ,color & ,*emical ,works & be+ presid5t ( ,victor ,koe*l ,co4 ,! ,g5]al ,drug ,company1 9 its price li/ to physicians1 li/s ! 8e?ical propriet>y0 pyramidon1 b conta9s no m5tion ( its 8pat5t m$ic9e0 ,midol4 ,,nurito ,midol is n ! only 8pat5t m$ic9e0 9 :i* pyramidon is ! ess5tial drug4 ,nurito1 :i* is adv]tis$ z 8n a pat5t m$ic9e b a propriet>y prep>ation10 is a no/rum put on ! m>ket by ! ,magi/ral ,*emical ,co41 ,new ,york4 ,"h are "s ( ! claims3 8,only ,u4 ,s4 ,p4 +r$i5ts are us$ 9 ,nurito40 8,gu>ante$ to relieve or y\r money refund$1 ,rheumatism1 ,sciatica1 ,neuritis40 8,!re is no comp\nd kn[n 9 m$ic9e t s rationally1 sci5tifically & effectively removes wa/e & poisons f ! human sy/em z ,nurito40 ,! ,association's laboratory rec5tly analyz$ a specim5 ( ,nurito4 ,! report foll[s3 ,a doll>-size package ( ,nurito 0 pur*as$ & f\nd to conta9 sev5 p[d]s4 ,! p[d]s rang$ 9 weight f #i to #ab gra9s1 ! av]age weight be+ ne>ly #aa gra9s4 ,! pres5ce ( pyramidon1 ph5olph?ale9 & milk sug> 0 demon/rat$4 ,alkaloids1 acetanilid1 acetph5etid91 *lorids1 bromids1 iodids1 heavy metals1 />* & sulphates 7 abs5t4 ,quantitative exam9ation indicat$ t ! composition ( ,nurito is ess5tially z foll[s3 ,milk sug> #cd p] c5t4 ,ph5olph?ale9 #f p] c5t4 ,pyramidon #fj p] c5t4 ,ea* p[d]1 !re=e1 conta9s ab\t #b-b_/c gra9s ( milk sug>1 #b_/c ( a gra9 ( ph5olph?ale9 & #f-b_/c gra9s ( pyramidon4 ,:at 0 said ( pyramidon 9 ! prec$+ article applies equally well "h4 ,! claim t ,nurito is compos$ ( 8,u4 ,s4 ,p4 +r$i5ts0 is evid5tly a falsehood4 ,! *ief !rapeutic +r$i5ts are pyramidon & ph5olph?ale91 nei!r ( :i* is describ$ 9 ! ,unit$ ,/ates ,ph>macopeia4--7,f ! ,j\rnal ,a4 ,m4 ,a41 ,aug4 #aj1 #aiab47 ,,mu-,,col ,salt & ,borax z ,wond]-,work]s 8,mu-col1 = ,cleans+ ,muc\s ,membranes0 is a no/rum put on ! m>ket by ! ,mu-col ,company 7,inc471 ,buffalo1 ,new ,york4 ,z a specim5 ( ! claims made = ! prep>ation1 ! foll[+ is typical3 8,mu-col obta9s mo/ gratify+ results 9 cat>rhal inflammations ( ! muc\s membranes4 ,leucorrhea1 ,tonsillitis1 ,sore ,?roat1 ,cy/itis1 ,int]nal ,hemorrhoids1 ,nasal ,cat>rh & ,pus ,cases respond at once to irrigation ) ,mu-col solution4 ,/rong solutions ( ,mu-col h prov5 ( /]l+ value 9 treat+ ,hives1 ,prickly ,heat1 ,ivy ,poison1 ,sunburn1 ,eczema1 ,typhoid & ,sc>let ,fev]40 ,?is1 & mu* m ,mu-col w d--accord+ to its manufactur]s6 ,no wond] physicians want to "k ! composition ( ,mu-col4 ,z ! manufactur]s d n give ?is in=mation ! aid ( ! ,association's ,laboratory 0 invok$4 ,let ! *emi/s speak3 ,,laboratory ,,report 8,! specim5 exam9$ 0 a :ite p[d]1 & f ! odor1 ?ymol1 eucalyptol1 camphor & oil ( w9t]gre5 c\ld be recogniz$4 ,qualitatively sodium1 *lorid & borate 7 f\nd4 ,z9c1 b5zoate1 ph5olsulphonate & sulphate c\ld n be f\nd4 ,! solution 0 alkal9e to litmus4 ,gravimetric det]m9ation ( *lorid z silv] *lorid & titration ( borax by ,?ompson's me?od indicat$ sodium *lorid 7,na,cl7 #dg4b p] c5t41 sodium borate 7,na#b;,b#d,o#gaj;,h#b,o7 #ej4a p] c5t4 8,x ?us appe>s t ,mu-col is a mixture ( ord9>y salt & borax 9 equal p>ts ) ! addition ( a small am\nt ( aromatic sub/ances40 ,mu-col w d j :at a solution ( salt & borax w d--no m1 no less4 ,& yet1 x is claim$3 8,mu-col has be5 successfully us$ s9ce ! ye> #aijj by m ?an #ej1jjj physicians1 :i* has prov5 x to be ! mo/ ,effici5t1 ,economical & acceptable1 prep>ation 9 its field40--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,feb4 #g1 #aiad47 ,,n>k9e ,! ,intangible ,product ( ! ,tild5 ,laboratory ,a little book1 publi%$ by ! ,druggi/s ,circul>1 & call$ 8,mod]n ,mat]ia ,m$ica10 gives 9 diction>y =m ! in=mation reg>d+ new rem$ies :i* t j\rnal publi%es 9 its mon?ly issues4 ,su* in=mation is n always acceptable to ! manufactur]s ( v>i\s prep>ations ( d\btful value4 ,a case 9 po9t is br\ght to notice ) ref]5ce to a rem$y call$ ,n>k9e1 put out by ! ,tild5 ,company ( ,/4 ,l\is4 ,9 ?is little book ! foll[+ appe>s3 8,n>k9e is describ$ z #8an opium prep>ation f :i* all delet]i\s qualities h be5 elim9at$'2 an unsupportable claim1 z all opiates & o!r hypnotics are ess5tially delet]i\s40 ,! ,tild5 ,company wrote to ! ,druggi/s ,circul>1 /at+ t !y gu>ante$ ,n>k9e 8to be absolutely free f coal-t> or opium d]ivatives10 yet ! 8lit]ature0 ( ! company describes x z 8a specially prep>$ product ( opium devoid ( ! nauseat+ & disagreeable prop]ties ( ?is drug1 yet possess+ ! anodyne & soporific pr9ciples ( same 9 ! highe/ degree40 ,to remove f opium all its d]ivatives & yet reta9 ! anodyne & soporific pr9ciples atta*$ to no?+ 9 p>ticul>1 indicates a degree ( ph>maceutical skill seldom atta9$4 ,"o is irresi/ibly rem9d$ ( ! ,*e%ire cat 9 8,alice 9 ,wond]l&10 ^: smile rema9$ long aft] ! cat _h vani%$4 ,! absurdity ( ! ?+1 h[ev]1 has app>5tly n occurr$ to _m physicians1 = ^! disembodi$ spirits ( ! ph>macologic _w are evid5tly be+ prescrib$4 ,! ,druggi/s ,circul> is to be congratulat$ on expos+ ?is late/ ph>maceutical freak4 ,x does s 9 a r /rik+ mann] by means ( photographic reproductions ( ! claims ( ! ,tild5 ,company4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,oct4 #bd1 #aijh47 ,,pap9e ,a ,disguis$ ,morph9 ,solution ,to ! ?9k+ physician x %\ld be evid5t t a prep>ation conta9+ morph9 mu/ possess n only all ( ! valuable prop]ties ( ?is drug1 b also all ( ! objectionable ones4 ,!re are /ill "s physicians1 app>5tly1 :o give cr$5ce to ! ass]tions ( ! manufactur]s conc]n+ ! morph9 prep>ation f :i*1 x is claim$1 all ( ! undesirable morph9 effects h be5 remov$4 ,! foll[+ qu]y f a correspond5t illu/rates ?is fact3 8,w y in=m me z to ! cont5ts ( #8,pap9e'8 ,i h a case ( *ronic int]/itial nephritis1 & my consultant insi/s on giv+ ?is prep>ation4 ,i ask$ him if he knew :at drugs x conta9$ & 8 answ] 0 #8"o-eigh? ( a gra9 ( morph9 ) ! objectionable p>ts ( ! drug remov$4'0 ,! qu]y 0 ref]r$ to ! ,association ,laboratory1 :i* submitt$ ! foll[+ report3 ,= _m ye>s ,pap9e has be5 adv]tis$ by its mak]s1 ,battle ,company1 ,/4 ,l\is1 z an anodyne4 ,9 ! circul>s ,pap9e is describ$ 9 "p z foll[s3 8,pap9e repres5ts 9 ph>maceutical =m ! purely anodyne pr9ciples ( opium fre$ f ! n>cotic & tetanis+ con/itu5ts40 8,pap9e is ! anodyne or pa9-reliev+ pr9ciple ( opium1 ! n>cotic & convulsive elem5ts be+ elim9at$4 ,"o fluid dra*m is equal 9 anodyne p[] to "o-eigh? gra9 ( morph940 8,?r\gh special me?ods ( prep>ation1 ! anodyne & analgesic pr9ciples ( ,papav] somnif]um are s extract$ z to free !m ( ! n>cotic & convulsive elem5ts t ev] h be51 & mu/ ev] cont9ue to be s]i\s objections to ! use ( opium & its common d]ivatives4444 ,no dem& is m regul>ly made on ! physician ?an t = ! relief ( pa91 & to be able to af=d x promptly & completely1 )\t ! slighte/ delet]i\s action1 is an advantage t _c be ov]e/imat$40 8,unlike mo/ d]ivatives & prep>ations ( opium1 ,pap9e nei!r nauseates nor con/ipates2 nor does x inhibit ! secretory functions ( ! body40 8,9 conditions ( extreme n]v\sness1 especially 9 wom51 rec\rse to morph9 is att5d$ by ! v real dang] ( ! =mation ( a habit4 ,la/ly1 opium & its alkaloids mu/ n be adm9i/]$ to p]sons ^: kidneys are n 9 good work+ ord] on acc\nt ( ! risk ( toxic accumulation40 8,no su* re/riction exi/s 9 respect ( ,pap9e1 its action be+ ex]t$ exclusively on ! elem5t pa92 9 o!r words1 x is purely anodyne40 8,pap9e does n nauseate1 con/ipate nor create a habit40 ,illu/ration3 ,! ,pap9e label be=e 7on left7 & aft] 7on "r7 ! passage ( ! ,food & ,drugs ,act4 ,& ! exploit]s ( ?is morph9 solution h ! effront]y to claim t x does n create a habit6 ,f ^! /atem5ts ! incauti\s physician might be l$ to inf] t ,pap9e is a prep>ation analog\s or simil> to ! (ficial t9cture ( deodoriz$ opium4 ,=m]ly 9 ! manufacture ( ! latt] prep>ation1 9 addition to removal ( ! odor\s sub/ances1 n>cot91 !n ?\ght to be ! pr9cipal convulsive alkaloid1#aaj 0 also remov$4 ,by ! process = ! manufacture ( ?is t9cture1 :i* is n[ (ficial 9 ! ,unit$ ,/ates ,ph>macopeia1 mo/ ( ! n>cot9e is f\nd 9 ! f9i%$ prep>ation4 ,:ile x is a comp>atively simple matt] to remove ! n>cot9 f opium & its prep>ations1 ?us elim9at+ mo/ ( ! commonly reput$ 8convulsive elem5ts10#aaa to remove ! 8n>cotic elem5ts0 f opium w\ld result 9 de/roy+ ! integrity ( ! product4 ,! reasons = ?is are t morph9 is ! mo/ p[]ful n>cotic sub/ance f\nd 9 opium1 & x is pres5t 9 ! l>ge/ proportion ( any ( ! alkaloidal con/itu5ts4 ,its removal f an opium prep>ation w\ld1 !re=e1 r5d] t prep>ation practically valueless4 #aaj ,n>cot9 is n[ kn[n to possess v little physiologic effect4 #aaa ,( ! opium alkaloids1 laudan9 & !ba9 possess ! mo/ p[]fully tetaniz+ prop]ties1 b !y are pres5t 9 opium 9 too small quantities to produce any noticeable effect4 ,nei!r ( ^! alkaloids is remov$ by ! usual processes = 8d5>cotiz+0 opium4 ,f ,pap9e1 h[ev]1 ! morph9 has n be5 remov$1 = s9ce ! passage ( ! ,food & ,drugs ,act ! label has to admit t ,pap9e conta9s #a gra9 ( morph9 9 ea* ounce6 ,a specim5 ( ,pap9e 0 exam9$ & f\nd to be no?+ m ?an a simple aque\s-alcoholic solution ( morph91 conta9+ glyc]94 ,! prep>ation is flavor$ to imitate *]ry & color$ ) co*9eal4 ,) ! exception ( morph91 nei!r n>cot91 code9 nor o!r opianic alkaloids 7 f\nd1 :ile meconic acid1 a *>act]i/ic con/itu5t ( opium1 0 abs5t4 ,s9ce ,pap9e is claim$ n to cause con/ipation1 & z is well kn[n1 ?is condition is frequ5tly produc$ by morph91 x seem$ possible t ,pap9e might conta9 laxative sub/ances4 ,on exam9ation1 h[ev]1 no casc>a1 rhub>b1 ph5olph?ale9 or laxative salts 7 f\nd4 ,:ile ,battle ,co4 h p]si/5tly exploit$ ,pap9e z be+ an opium prep>ation hav+ none ( ! objectionable qualities ( opium1 ! analysis %[s t ! p>adoxical claims made = x _c be sub/antiat$4 ,9 prescrib+ morph9 !re is an abundance ( (ficial prep>ations to *oose f1 & !re c]ta9ly is no necessity or excuse = resort+ to ! mu* m exp5sive & 9 no way sup]ior ,pap9e4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,april #bi1 #aiaa47 ,,pasadyne,,aw ,,aw ,see also report on ,passiflora & ,daniel's ,t9cture1 p4 #aef4 ,a physician asks3 8,c y tell me ! =mula ( a prep>ation on ! m>ket call$ ,pasadyne1 put up by ,john ,b4 ,daniel1 ,atlanta1 ,georgia80 ,accord+ to ! manufactur] ,pasadyne is a t9cture ( passion-fl[]4 ,=m]ly ?is no/rum 0 sold "u ! title 8,daniel's ,conc5trat$ ,t9cture ( ,passiflora ,inc>nata40 ,:ile ! manufactur] claims m>vel\s virtues = ?is prep>ation1 made f 8! fruit1 roots & v9es ( ! passion-fl[] or ,may-pop10 passiflora 7passion fl[]7 is n[ g5]ally recogniz$ z be+ ( little if any value4 ,a circul> makes ! foll[+ absurd /atem5t3 8,*loral & ! bromids1 be=e ! recognition & adv5t into m$ic9e ( ,pasadyne 7,daniel's ,conc5trat$ ,t9cture ( ,passiflora ,inc>nata71 7 widely employ$ 9 all turbul5t /ates ( ! psy*e &1 not)/&+ _! _m unt[>d1 ev5 sometimes dang]\s effects1 7 held 9 high favor by physicians4 ,= t matt]1 !y /ill reta9 "s ( _! old-"t popul>ity1 b s9ce ! sup]ior value ( ,pasadyne 7,daniel's ,conc5trat$ ,t9cture ( ,passiflora ,inc>nata7 has be5 demon/rat$ to ! pr(ession's satisfaction1 ! er/:ile high e/eem 9 :i* *loral & ! bromids 7 held1 is fa/ wan+ & ere long ,pasadyne w h cr[d$ !m out40 ,! reasons :y ! drug passiflora 0 n deem$ ( suffici5t value & h5ce1 along ) ! ,daniel prep>ation1 0 refus$ recognition1 are giv5 9 a report ( ! ,c\ncil on ,ph>macy & ,*emi/ry4--7,ab/ract$ f ,! ,j\rnal ,a4 ,m4 ,a41 ,m>* #h1 #aiac47 ,,pas-,,av5a ,h[ ,its ,=mula ,evades ! ,food & ,drugs ,act ,pas-,av5a is a widely adv]tis$ 8n]ve s$ative & hypnotic40 ,! prep>ation is put on ! m>ket by ! ,pas-,av5a ,company ( ,new ,york ,city4 ,z a headl9] ! adv]tisem5ts ( ! rem$y /ate t ! =mula has always be5 on e bottle1 & ?is1 ,! ,j\rnal /ates1 has a tw(old object3 ,x aims to give ! impression t ! prep>ation is non-secret1 & x is calculat$ to inspire confid5ce 9 !--app>5tly--sci5tific nature ( ! product4 ,z a matt] ( fact1 x %\ld d nei!r4 ,! prep>ation is ess5tially secret 9 its composition because ( ! pres5ce 9 ! =mula ( an unkn[n quantity & ! liability to *ange ( =mula at ! :im ( ! manufactur]4 ,on ! bottles "s "t ago ! foll[+ =mula 0 giv53 ,ea* tablespoonful conta9s3 ,passiflora #bj m9ims4 ,av5a sativa #aj m9ims4 ,somnalges9e 7,c#cj;,h#bh,n#e,o#f7 #b gra9s4 ,! fir/ two +r$i5ts are plants 9 ^: !rapeutic value b little confid5ce is plac$4 ,somnalges9e1 ! ?ird con/itu5t1 is a secret prep>ation1 ! *emical =mula ( :i* ! manufactur]s 7 k9d en\gh to add4 ,to a *emi/1 h[ev]1 ! =mula is absurd & impossible1 & is includ$ ei!r because ( ! manufactur]'s ignorance or because ( an int5t to deceive ! pr(ession4 ,s9ce ! ,food & ,drugs ,act became law1 ! label ( ,pas-,av5a has be5 *ang$ to read3 ,alcohol #h4cg p] c5t4 by volume4 ,anilipyr9e #af4jj gra9s p] fluid ounce4 ,gu>ante$ "u ! ,food & ,drugs ,act ( ,june #cj1 #aijf4 ,sub/itution ( anilpyr9e = somnalges9e gives little m in=mation4 ,*emi/s may recognize ?is z a "n appli$ to a mixture said to be =m$ by ! fusion ( two molecules ( antipyr9 & "o molecule ( acetanilid4 ,to physicians1 h[ev]1 ! "n c>ries ) x ! same my/]y z did somnalges9e4 ,att5tion is direct$ to ! fact t by publi%+ ! gu>antee "u ! pure food laws ! company presumes to disp]se all d\bt & criticism1 assum+ t ! majority ( physicians w be satisfi$ ) ! gu>antee z x /&s4 ,inasmu* z ! prep>ation conta9s acetanilid & antipyr91 h[ev]1 ! manufactur]s are disreg>d+ t "p ( ! ,food & ,drugs ,act :i* requires t ! "n ( ! p>5t sub/ance--9 ?is case acetanilid & antipyr9--be put 9 p>5!sis4 ,! laws are s well def9$ t physicians appe> to be cont5t to d no?+1 firmly believ+ t !y are safe f ! defraud+ me?ods ( unscrupul\s manufactur]s4--7,ab/ract$ f ,! ,j\rnal ,a4 ,m4 ,a41 ,m>* #g1 #aijh47 ,propriet>y ,h\se ,insolv5t--& ,physicians ,lose8 ,! ,pas-,av5a ,*emical ,company1 ^: product1 ,pas-,av5a1 0 expos$ 9 ,! ,j\rnal a few mon?s ago1 has rec5tly fail$1 accord+ to our ph>maceutical ex*anges4 ,9 record+ ! fact1 "o j\rnal says3 8,x is report$ t consid]able /ock ( ?is company _h be5 sold to physicians40 ,at ?is "t1 :5 physicians are importun$ daily to inve/ money 9 v>i\s wildcat ph>maceutical conc]ns1 ?is s5t5ce might well be us$ 8to po9t a moral or adorn a tale40 ,,p]tuss9 ,dr4 ,l4 ,a4 ,rob]ts1 ,dor*e/]1 ,mass41 writes3 8,please tell me :at ! composition ( ,p]tuss9 is40 ,p]tuss9 is a propriet>y :oop+-c\gh rem$y manufactur$ by ! ,komm&antan ,apo!ke1 ,b]l94 ,a 8physician's sample0 bottle ( ?is prep>ation s5t out by ,lehn ,f9k be>s a label on :i* appe>s ! foll[+3 8#ajj p>ts ,p]tuss9 conta9s3 #a_/b ,ol4 ,?ymi1 et ,?ymol #ba-a_/b ,ext4 ,?ymi #8,taes*n]' #ej ,sac*>um #b ,glyc]9um #f-a_/d ,alcohol #ai-c_/d ,aqua ,de/illata0 ,:ile x nev] has _h mu* vogue 9 ?is c\ntry x has be5 & /ill is us$ 9 ,g]many4 ,x belongs to t class ( vegetable prep>ations :i*1 s9ce !y conta9 no di/9ctive pr9ciple1 are difficult to analyze--p>ticul>ly z conc]ns ! 8jok]0 9 ! =mula1 9 ?is case 8,ol4 ,?ymi1 et ,?ymol0 & 8,ext4 ,?ymi #8,taes*n]'0--h5ce !re has be5 mu* dispute 9 ,g]many z to ! composition ( ?is no/rum4 ,9 g5]al1 x appe>s t :atev] virtues x has are due to "s prep>ation ( common ?yme 9 a m5/ruum conta9+ wat]1 sug> & alcohol4 ,at "o "t ! prep>ation 0 f\nd to conta9 potassium bromid2 b te/s rec5tly made 9 ! ,a4 ,m4 ,a4 ,*emical ,laboratory indicat$ ! abs5ce ( ei!r bromids or iodids4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,m>* #h1 #aiac47 ,,ph5alg9--,a ,,typical ,,example,,ax ,,ax ,= reports & articles on o!r coal-t> prep>ations1 see pp4 #i1 #aae1 #bdd1 #bfh1 #cje4 ,la/ ,june#aab we devot$ consid]able space to ! extravagant !rapeutic claims made = 8,ph5alg90 by its v5d]s4 ,at ?is "t we propose to ref] to ! mis9=mation--to use a cons]vative t]m--t ! ,etna ,*emical ,company has promulgat$ reg>d+ ! composition ( _! prep>ation4 #aab ,see ,! ,j\rnal ,a4 ,m4 ,a41 ,june #bd1 #aije1 p4 #aiig4 ,9 ,june1 #aije1 ! ,c\ncil on ,ph>macy & ,*emi/ry (ficially publi%$ to ! m$ical pr(ession ( ! ,unit$ ,/ates ! in=mation t repeat$ exam9ations %[$ t 8,ph5alg90 is a simple mixture ( acetanilid & sodium bic>bonate or ammonium c>bonate4 ,s f> z we "k1 no direct d5ial ( ! tru? ( ?is has be5 made4 ,!re has appe>$ :at we presume is meant z an answ]2 x is c\*$ 9 ?is s5t5ce1 ,ph5alg9 is j :at we h always said x to be4 ,f ?is expression--:i* has be5 repeat$ 9 bold1 black lett]s 9 practically all ! adv]tisem5ts s9ce la/ ,june--we presume t we are to und]/& t 9 ! pa/ !y h /at$ :at x is4 ,x w\ld h be5 j z easy & m satisfactory if ! ,ph5alg9 p1 in/ead ( say+3 8,ph5alg9 is j :at we h always said x to be10 _h said :at x is1 s9ce ! av]age physician has nei!r ! "t nor ! incl9ation to look up _! lit]ature4 ,= ! b5efit ( ^? :o desire to "k :at ! v5d]s ( ,ph5alg9 8h said x to be10 we h gone ov] _! adv]tis+ lit]ature ( ! pa/1 ) ! foll[+ results1 :i* are 9 ! =m ( quotations f _! adv]tisem5ts3 ,an ,am]ican ,coal-,t> ,product--,ph5alg9--! only syn!tic /imulant1 non-toxic1 antipyretic1 analgesic & hypnotic4 ,ph5alg9 is ! ,,only ammoniat$ ,syn!tic ,coal-,t> ,product made f ,*emically ,pure ,mat]ials ,:at h ! ,ammonol p to say to ?is8--,ed4 ,a syn!tic ,coal-,t> ,product ( ! ,amido-,b5z9e s]ies1 conta9+ ,nasc5t ,ammonia4 ,^! two *emicals 8/imulant ammonia ( coal-t> orig90 & 8*emically pure ph5ylacetamid0 comb9e "u c]ta9 conditions s z to obta9 a produce :i* he ,dr4 ,cyrus ,edson nam$ ,ph5alg9 or ,ammoniat$ ,ph5ylacetamide4 ,ph5alg9 is a comp\nd ( peculi> "* :i* c n be extemporane\sly made into tablets f ! p[d]$ drug1 )\t s]i\sly *ang+ & impair+ its m$ic9al qualities4 ,we believe ^! quotations are suffici5t to %[ :at ! ,etna ,*emical ,company has 8always said x to be40 ,9 go+ ov] ! lit]ature = sev]al ye>s pa/ we f9d ! above /at$ 9 ! same1 or simil>1 words 9 ne>ly all ( x4 ,f ! above f\r /atem5ts may be d$uc$3 #a4 ,!y h /at$ t ,ph5alg9 is a syn!tic#aac prep>ation2 #b1 !y h convey$ ! impression t ,ph5alg9 is a *emical comp\nd2 #c1 !y h ann\nc$ repeat$ly t x is ! 8only0 prep>ation ( ! k9d1 & #d1 !y h claim$ t ,ph5alg9 is non-toxic4 #aac ,dunglison's ,diction>y3 8,syn!tic--,9 *emi/ry ! =mation ( a m complex body by ! union ( simpl] bodies40 ,dorl&'s ,diction>y3 8,syn!sis--,! artificial build+ up ( a *emic comp\nd by ! union ( its elem5ts40 8,union0 is n mix+4 ,we believe t ^! f\r /atem5ts repres5t 9 pla9 ,engli% :at ! above quotations mean4 ,!y are all absolutely false4 ,ph5alg9 is n syn!tic2 x is n a *emical comp\nd2 x is n ! only ammoniat$ ph5ylacetamide1 or ! only acetanilid mixture conta9+ c>bonate ( ammonium--& x is mo/ positively toxic4 ,9 "o place x is /at$ t ,dr4 ,cyrus ,edson ,employ$ 8 great facilities = *emical rese>* & opportunities = *emical exp]im5t = ! purpose ( produc+ a =mula = a comb9ation ( /imulant ammonia ( coal-t> orig9 7sic7 & *emically pure ph5ylacetamide1 also a coal-t> product 444 :i* he nam$ ph5alg91 or ammoniat$ ph5ylacetamide4 ,9 ano!r place we read t ,ph5alg9 is made ,"u ! imm$iate p]sonal sup]vision ( ! orig9al inv5tor ( ammoniat$ coal-t> products4 ,by comp>+ ?is la/ quotation--:i* is f a curr5t--#aije--;adv]tisem5t--) ! prec$+ "o x w be notic$ t we are ask$ to believe t ,ph5alg9 is made 8"u ! imm$iate sup]vision (0 ,dr4 ,cyrus ,edson--& yet ,dr4 ,cyrus ,edson di$ ,dec4 #b1 #aijc4 ,?is is equal to ,lydia ,p9kham's prescrib+ = ! suff]+ wom5 ( ,am]ica :5 ! de> old s\l _h be5 dead = ov] tw5ty ye>s4 ,we h be=e u a full-page adv]tisem5t tak5 f a rec5t numb] ( a weekly m$ical j\rnal1 :i* possibly is meant z an answ] to ! ann\ncem5t ( ! ,c\ncil on ,ph>macy & ,*emi/ry t ,ph5alg9 is a simple acetanilid mixture4 ,! adv]tisem5t is divid$ into two p>ts2 ! fir/ "p is z foll[s3 ---------------------------------------- ------------------- ,,facts ,,ab\t ,,acetanilidum 7,,anci5t ,,hi/ory7 ,x has long be5 recogniz$ t ,acetanilidum & mo/ o!r coal-t> products are apt to ex]t a depress+ influ5ce ^u ! he>t1 b !re has nev] be5 any d\bt ab\t its great value z a pa9 reliev] & temp]ature r$uc]4 ,its !rapeutic value has1 h[ev]1 be5 practically nullifi$ by ! dang] ( cyanosis & o!r evils caus$ by its well-kn[n depressant action & ! difficulty ( obta9+ x 9 a pure /ate4 ,x be+ kn[n t c]ta9 delet]i\s sub/ances are (t5 to be f\nd 9 ,comm]cial ,acetanilidum & t mu* ( ! injuri\s effect attribut$ to ?is drug is entirely traceable to ^! impurities4#aad ---------------------------------------- ------------------- #aad ,?is s5t5ce is n complete1 b1 ( c\rse1 ?is is immat]ial4 ,little ?+s l an incomplete s5t5ce d n c\nt4 ,! above are also falsehoods4 ,! !rapeutic value ( acetanilid is n 8practically nullifi$ 444 by ! difficulty ( obta9+ x 9 a pure /ate40 ,nei!r is x true t 8mu* ( ! injuri\s effect attribut$ to ?is drug is entirely traceable to ^! impurities40 ,:ile delet]i\s sub/ances may be f\nd 9 comm]cial acetanilid1 !y are n f\nd 9 ! sub/ance (f]$ z m$ic9ally pure acetanilid by reputable firms4 ,pure m$ic9al acetanilid is a *eap article1 co/+ less ?an #cj c5ts a p\nd1 = x is a sub/ance t is easily & *eaply purifi$4 ,x is a fact t ! injuri\s effects are 9 ! acetanilid itself & n 9 ! impurities x may occasionally conta94 ,! second half ( ! adv]tisem5t 9 "p is z foll[s3 ---------------------------------------- ------------------- ,,facts ,,ab\t ,,ph5alg9 7,,mod]n ,,sci5ce7 ,m ?an a decade ago ! late ,dr4 ,cyrus ,edson1 !n ,heal? ,commission] = ,new ,york ,city & ,new ,york ,/ate1 recogniz+ ! value ( *emically pure ,acetanilidum z a !rapeutic ag5t1 if x c\ld be depriv$ ( its depressant quality1 employ$ 8 great facilities = *emical rese>* & opportunities = *emical exp]im5t = ! purpose ( produc+ a =mula = a comb9ation ( ,/imulant ,ammonia ( coal-t> orig9 & *emically pure ,ph5ylacetamide1 also a coal-t> product4 ,^! two *emicals comb9e "u c]ta9 conditions s z to obta9 a product :i* he nam$ ,ph5alg9 or ,ammoniat$ ,ph5ylacetamide4 ---------------------------------------- ------------------- ,!re is m ( ! same "*4 ,9 ! fir/ place1 we call att5tion to ! fact t 8,ph5ylacetamide0 is sub/itut$ = 8,acetanilidum0 :5 x is to g into ,ph5alg94 ,to my/ify is "o ( ! 8tricks ( ! trade40 ,few physicians keep up ) *emical t]ms &1 !re=e1 are n suppos$ to "k t ,ph5ylacetamide is "o ( ! *emical names = ,acetanilid4 ,! ref]5ce "h to ,dr4 ,cyrus ,edson br+s up ano!r fact1 & t is t ! ,etna ,*emical ,company tries to convey ! idea t ,dr4 ,edson 0 ! orig9ator ( ,ph5alg94 ,we h always und]/ood t ,dr4 ,cyrus ,edson _h some?+ to d ) pu%+ ,ammonol &1 if we rememb] rightly1 got into "s tr\ble !reby4 ,we d n "k ! exact facts1 b ! foll[+ lett] %[s t he _h a lean+ t[>d ano!r 8ammoniat$ ph5ylacetamid40 ,! lett] is dat$ 8,new ,york1 ,oct4 #f1 #ahid10 & is address$ to ! 8,ammonol ,*emical ,company40 8,dur+ ! pa/ six or eight mon?s ,i h us$ ,ammonol ext5sively 9 my private practice4 ,i h f\nd x excell5t 9 ! treatm5t ( neuralgias & = rheumatism4 ,i h also v]ifi$ y\r /atem5t 9 two cases t 7 suff]+ f alcoholism4 ,my exp]i5ce ju/ifies me 9 say+ t x is ! safe/ & be/ ( ! analgesic coal-t> d]ivatives4 8,v truly y\rs1 ,cyrus ,edson1 ,m4,d40 ,x may be ( int]e/ to "k t ! pr9cipal memb] ( ! firm ( ! ,etna ,*emical ,company 0 at "o "t a memb] ( ! ,ammonol ,company1 & x is usually und]/ood1 we believe1 t ,ph5alg9 is practically ! same z ,ammonol--9 fact1 ! analyses publi%$ reg>d+ ! two prep>ations %[ ?is to be a fact4 ,we mu/ make "o m quotation3 ,x makes little diff]5ce to a physician :e!r ,ph5alg9 is a mixture or a comp\nd or a syn!tic1 ) a "n t w\ld de/roy ! or?ographic balance ( ! univ]se1 provid$ x is j :at he has always f\nd x to be4 ,v complim5t>y to ! intellig5ce & common s5se ( physicians1 is x n8 ,suppose "s fell[ %\ld get up a s*eme to exploit a mixture ( qu99 & "s *eap1 h>mless sub/ance1 say1 />*--equal p>ts ( ea*4 ,suppose he gives x a fanciful "n1 puts x on ! m>ket at a high price1 say #a4be an ounce1 & ann\nces x z a new syn!tic ) wond]ful !rapeutic qualities4 ,suppose t ! s*em] !n adopts ! no/rum v5d]'s me?ods ( fool+ physicians into us+ 8 product by gett+ "s to give te/imonials1 o!rs to furni% write-ups1 & !n subsidizes m$ical j\rnals ?r\gh lib]al adv]tis+ to pr9t bo? ! te/imonials & ! write-ups4 ,! prep>ation w\ld1 ( c\rse1 prove to be a good ?+ if x 7 us$ 9 lib]al quantities :]e qu99 w\ld ord9>ily be us$1 & "s pati5ts us+ x w\ld get well ev5 if qu99 7 n indicat$4 ,!n ) ! psy*ologic effect ( ! te/imonials1 ! write-ups1 & good1 /rong claims rightly pu%$1 un?9k+ physicians w\ld d ! re/4 ,& !n1 aft] a :ile1 :5 ! s*em] _h gott5 to ! po9t :]e1 ea* ye>1 he 0 mak+ a =tune out ( 8 prep>ation1 suppose "s 8self-appo9t$ *emi/s0 %\ld exam9e into ! prep>ation & discov] t x 0 no?+ b qu99 & />*1 & s ann\nce to ! doctors ( ! c\ntry2 :at w\ld ! doctors say8 ,t x makes little diff]5ce 8provid$ x is j :at he has always f\nd x to be60 ,?is analogy is n f>-fet*$1 = x is practically :at has be5 done ) ,ph5alg94 ,"o diff]5ce is t s9ce qu99 co/s z mu* p] ounce z acetanilid does p] p\nd1 ! pr(its on ! acetanilid mixture w\ld be sixte5 times great] ?an t ( our imag9>y prep>ation4 ,ano!r diff]5ce is t acetanilid is really a dang]\s drug1 unless us$ ) c>e1 bo? 9 its imm$iate & 9 its remote effects2 qu99 is f> less s4 8,little diff]5ce0 inde$1 :e!r we are be+ bunco$ or n6 ,evid5tly6 ,9 conclusion1 we *>ge ! ,etna ,*emical ,company ) int5tionally mislead+ & deceiv+ ! memb]s ( ! m$ical pr(ession1 9 t ! said company has 9 its lit]ature & its adv]tisem5ts convey$ ! impression 7:e!r directly /at$ or n73 ,fir/1 t its prep>ation1 ,ph5alg91 is a syn!tic comp\nd2 second1 t ,ph5alg9 requires special skill 9 its prep>ation2 ?ird1 t ,ph5alg9 has !rapeutic values :i* x does n possess2 &1 f\r?1 t ,ph5alg9 is non-toxic4 ,we also *>ge t on acc\nt ( ^! & o!r misrepres5tations1 ?is company has inveigl$ physicians into prescrib+ & us+ a simple me*anical mixture ( common well-kn[n *eap drugs--= :i* an extravagantly high price is *>g$--"u ! supposition t ?is comb9ation ( *eap drugs is a *emical comp\nd ( special & peculi> m]it z a !rapeutic ag5t1 &1 !re=e1 wor?y ( _! confid5ce4 ,our object 9 aga9 giv+ space to ?is prep>ation--& practically all we h said applies to ! o!r acetanilid mixtures t are exploit$ "u fictiti\s names or z *emical comp\nds 7su* z ammonol1 antikamnia & salacet9 or sal-codeia--,bell7--is to impress on physicians1 by a typical example1 ! %amefulness ( ! deceptions practic$ on !m by no/rum manufactur]s to ! great injury ( ! public & ( ! m$ical pr(ession4 ,a ,ph>maceutical ,secret ,:i* ,%\ld ,n ,be ,lo/ ,dr4 ,gregory ,co/igan1 ,new ,york ,city1 writes "u date ( ,janu>y #ba1 z foll[s3 8,i h be5 c>efully read+ & en?usia/ically approv+ y\r articles on ! no/rum evil1 & h be5 impress$ m ?an usual on ! exi/5ce ( quack adv]tis+ 9 m$ical j\rnals z set =? 9 la/ p>agraph & quotation on page #bjf1 bottom ( fir/ column1 ( y\r issue ( ,jan4 #bj1 #aijf4 8,9 ,m]ck's ,ar*ives1 page #aa1 we are told 9 an adv]tisem5t on #8,ph5alg9' t x #8is a comp\nd ( peculi> "* :i* _c be extemporane\sly made f p[d]$ drug' & #8our process ( manufactur+ tablets is co9cid5t ) ! manufacture ( ,ph5alg9 & is ! result ( a long s]ies ( c>eful exp]im5ts by :i* we are able to produce tablets ( ,ph5alg9 9 a friable condition )\t los+ any ( its volatile con/itu5ts or und]go+ *emical *anges f heat or moi/ure'6 ,inasmu* z ,ph5alg9 tablets are n cov]$ ) a wat]pro( coat+ ,i ?9k ?is is a rem>kable /atem5t to make1 & ! manufactur+ ( a drug co9cid5t ) ! manufacture ( a tablet mu/ be a v rem>kable p]=mance1 especially because x #8reta9s ! full !rapeutic value ( ! drug unimpair$' :ile ! adv]tisem5t ass]ts t no o!r manufactur] is cognizant ( ?is wond]ful me?od4 ,?is ad4 is = ! p]usal ( physicians only4 ,! ,etna ,*emical ,company owes x to ! m$ical & ph>maceutical _w n to let ?is secret die ) ! company's dissolution4 ,x owes x z a duty to ! com+ g5]ations ( sci5ce imm$iately to jot d[n ! full data ( ?is wond]ful p]=mance1 to put x away 9 an age-pro( safe & n all[ x to be lo/ to humanity z 7 a great _m o!r arts t 7 well kn[n to ! anci5ts4 ,let !m keep x secret n[ & pr(it by x1 b d n let x be lo/ to po/]ity40--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #ac1 #aijf1 & ,jan4 #bi1 #aijf47 ,an ,e?ical 787 ,propriet>y ,exploit$ ,"u ,fraudul5t & ,ly+ ,claims ---------------------------------------- --------------------- 8,,ph5alg9 ,,is ,,j ,,:at ,,we ,,h ,,always ,,said ,,x ,,to ,,be40 --,etna ,*emical ,co4 9 #aije4 8,ph5alg9 is a syn!tic 8,unlike ! coal-t> syn!tic1 coal-t> product40 ph5alg9 is a /imulant --,etna ,*em4 ,co4 9 #ahih4 r ?an a depressant40 --,etna ,*em4 ,co4 9 #aiaj4 ,,tempus ,,omnia ,,revelat6 ---------------------------------------- --------------------- 8,ph5alg9 is a syn!tic coal-t> product0--?us ran ! adv]tisem5ts "s ye>s ago1 :5 ! m$ical pr(ession 0 will+ to take--or 0 compell$ to take--! ^w ( ! manufactur] ( propriet>y rem$ies at its face value4 ,!n ! ,c\ncil on ,ph>macy & ,*emi/ry 0 br\ght into exi/5ce4 ,"o ( ! fir/ pieces ( "w done by ! ,c\ncil 0 ! publication ( ! results ( a numb] ( analyses ( heada*e p[d]s4 ,ph5alg9 0 among !m4 ,analysis %[$ t ,ph5alg9 0 n a syn!tic b a simple mixture ( ! foll[+ +r$i5ts 9 ! proportions giv53 ,acetanilid #eg p>ts ,sodium bic>bonate #bi p>ts ,ammonium c>bonate #aj p>ts ,! ,etna ,*emical ,company1 :i* puts out ?is product1 0 consid]ably di/urb$ by ! ,c\ncil's exposure4 ,x 8came back0 at ! ,am]ican ,m$ical ,association ) ! slogan 8,ph5alg9 is j :at we h always said x to be40 ,:at1 up to t "t1 ! ,etna ,*emical ,company _h 8always said0 ,ph5alg9 to be1 03 #a4--,ph5alg9 is a syn!tic4 #b4--,ph5alg9 is ! only prep>ation ( ! k9d4 #c4--,ph5alg9 is non-toxic4 ,^!1 9 brief1 7 ! ?ree ?+s t ,ph5alg9 _h be5 ass]t$ to be4 ,ea* /atem5t has be5 prov$ to be a def9ite & unequivocal falsehood4 ,ph5alg9 is n & nev] 0 a 8syn!tic40 ,ph5alg9 is n & nev] 0 ! only acetanilid mixture conta9+ c>bonate ( ammonium4 ,ph5alg9 is n & nev] 0 9 any s5se ( ! ^w non-toxic4 ,ph5alg91 9 %ort1 possesses ! prop]ties--bo? good & bad--t are common to acetanilid4 ,x is a mixture t ! m]e/ tyro 9 ph>macy c\ld disp5se & = :i* any sophomore m$ical /ud5t c\ld write a prescription )\t /opp+ to ?9k4 ,acetanilid sells at #h c5ts an ounce :olesale2 ,ph5alg9 at #a4jj an ounce1 :olesale4 ,all ^! facts & _m m 7 giv5 to ! pr(ession by ! ,c\ncil on ,ph>macy & ,*emi/ry 9 ,! ,j\rnal m ?an six ye>s ago--be=e ev5 ! ,food & ,drugs ,act came into effect4 ,aft] t law became op]ative1 ! ,etna ,*emical ,company 0 compell$ to say some?+ on ! label t x _h nev] said be=e1 namely1 t ,ph5alg9 conta9$ #ej p] c5t4 acetanilid4 ,b ! law n only requir$ !m to add a fact to _! label1 b x also compell$ !m to remove a falsehood4 ,:5 ! pure food law w5t into effect1 ,ph5alg9 0 label$ a 8mal>ia g]micide40 ,x is n a mal>ia g]micide & nev] 0 a mal>ia g]micide1 & ! ,etna ,*emical ,company d>$ n risk tak+ ! "q into c\rt s x remov$ ! /atem5t4 ,un=tunately ! ,food & ,drugs ,act ex]cises no control ov] ! ly+ /atem5ts t may be made = drugs else:]e ?an on ! label4 ,s x is t physicians )9 ! la/ two or ?ree weeks h receiv$ a booklet on ,ph5alg9 conta9+ ! foll[+ ass]tions = ?is acetanilid mixture3 8,)\t ! slighte/ h>m1 injury or depress+ effect40 8,is nev] foll[$ by depression40 8,its prolong$ adm9i/ration does n give rise to de/ructive blood metamorphosis40 8,is ( great value 9 ! treatm5t ( neuralgia 7especially 9 ! anemic470 8,fre$om f ! delet]i\s action or habit-=m+ t5d5cies ( ! opiates40 8,x aids 9 de/roy+ ! mal>ial p>asite40 8,safe/ & mo/ dep5dable ( analgesics40 ,x w be se5 by ?is t :ile ! ,food & ,drugs ,act has =c$ a c]ta9 degree ( tru?fulness on ! ,ph5alg9 labels1 ! adv]tis+ matt] is z fraudul5t & z untru?ful z ev] x 04 ,x is true t ! ass]tion t x is a syn!tic is no long] made1 possibly because ! m$ical pr(ession has be5 s ?or\ghly enlight5$ on ! mu*-ov]work$ 8syn!tic0 fraud t ! falsehood is no long] pr(itable4 ,9 o!r respects1 ! ass]tions are j z false z ev]4 ,x is said to h no depress+ effect--& yet x is acetanilid4 ,x is said to produce no habit--& yet x is acetanilid4 ,x is said to h no injuri\s effect on ! blood--& yet x is acetanilid4 ,x is said to be ! safe/ analgesic--& yet x is acetanilid4 ,h[ long w ! m$ical pr(ession cont9ue to be hoodw9k$ by means ( su* transp>5t falsehoods8 ,! ,ph5alg9 conc]n takes mu* cr$it to itself because on ! c>tons 9 :i* ! bottles ( ,ph5alg9 come1 x is /at$ t ! product is 8= disp5s+ purposes only40 ,yet1 z a matt] ( fact1 practically any layman c g to any drug /ore & obta9 ?is product1 = ! druggi/ appraises ?is spectacul> piece ( ,pecksniffian virtue at its face value--a joke4 ,:y1 if int5d$ only = physicians1 w\ld x be necess>y to include ) e bottle a circul> nam+ ! diseases1 = :i* ?is acetanilid mixture is suppos$ to be good--8heada*e10 8colds10 8lumbago10 8scanty m5/ruation10 8pa9 9 any "p ( ! body0--& :y is ! "n ( ! product & ( ! firm mak+ x bl[n into ! bottle8 ,to sum up !n1 ,ph5alg9 is z big a humbug z ,p]una ev] 04 ,x is sold to-day "u claims t are j z false z ^? us$ six ye>s ago4 ,! ,etna ,*emical ,company is p]petrat+ a /up5d\s fraud on ! m$ical pr(ession to-day & x is do+ x n only ?r\gh ! ag5cy ( ! ,unit$ ,/ates mail1 b ) ! aid & support ( ! foll[+ m$ical j\rnals--& o!rs--9 :i* ! ,ph5alg9 adv]tisem5t appe>s3 ,m$ical ,record ,new ,york ,m$ical ,j\rnal ,p$iatrics ,lancet-,cl9ic ,am]ican ,j\rnal ( ,surg]y ,int]national ,j\rnal ( ,surg]y ,am]ican ,m$ic9e ,am]ican ,j\rnal ( ,ob/etrics ,m$ical ,c5tury ,pacific ,m$ical ,j\rnal ,dietetic & ,hygi5ic ,gazette ,m$ical ,/&>d ,eclectic ,m$ical ,j\rnal ,am4 ,j\r4 ( ,cl9ical ,m$ic9e ,x is conceivable t 9 "s cases x is n easy = ^? editors & publi%]s ( m$ical j\rnals :o insi/ on rely+ on _! own judgm5t to satisfy !mselves t c]ta9 prep>ations are n wor?y ( be+ adv]tis$4 ,no su* difficulty occurs 9 ! case ( ,ph5alg94 ,"h ! issues are cle> cut4 ,! product is exploit$ "u claims t are bo? false & vici\s & _! falsity & vici\sness are p]fectly evid5t to any fre%man m$ical /ud5t4 ,! only *>itable explanation ( ! appe>ance ( ! ,ph5alg9 adv]tisem5ts 9 ! m$ical j\rnals li/$ is t ! editors & publi%]s h n giv5 ! subject ! att5tion x des]ves & to :i* _! read]s are entitl$4 ,p]haps x w\ld help if _! att5tion 7 call$ to ! matt] by _! subscrib]s4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #bg1 #aiab47 ,,ph5o-,,bromate ,an analysis ( ?is prep>ation made at ! in/ance ( ! ,new ,hav5 ,m$ical ,association1 by its *emi/1 & s5t by ,dr4 ,*>les ,j4 ,foote ( ,new ,hav5 to ,! ,j\rnal is 9 "p z foll[s3 ,! package 0 m>k$ 8,sample package1 ,ph5o-,bromate4 ,! ,ph5o-,bromate ,company1 ,new ,york1 ,u4 ,s4 ,a40 ,! box conta9$ a numb] ( tablets & a package ( p[d]s 9 pap]s m>k$1 8,physicians' #aj gra9 p[d]s1 ,ph5o-,bromate40 ,! sub/ance 9 ! pap]s 0 a :ite cry/all9e p[d] n homog5e\s4 ,x 0 completely soluble 9 hot wat]4 ,! hot wat] solution on cool+ yield$ a mass ( ?9 cry/all9e plates4 ,?is mat]ial 0 f\nd to melt at #aac4e ,c4 ,x gave no color ) f]ric *lorid & a positive isonitril te/4 ,! portion insoluble 9 e!r am\nt$ to #di4h p] c5t4 ( ! p[d] & consi/$ ( potassium bromid4 ,quantitative det]m9ations ( potassium & brom9 9 ! orig9al solution confirm$ ?is result4 ,9 my op9ion1 ! p[d] consi/s ( approximately equal quantities ( acetanilid & potassium bromid4 ,qualitative te/s ( ! tablets indicat$ t !y _h ! same composition except = a small quantity ( "s excipi5t n entirely soluble 9 wat]4 ,y\rs truly1 ,h]b]t ,e4 ,smi?1 ,*emi/ ,new ,hav5 ,m$ical ,association4 ,be=e ! ,food & ,drugs ,act ,ph5o-,bromate 0 adv]tis$ z 8a syn!tic comb9ation ( ! ph5etid9 & bromid gr\ps1 & n1 z is ! case ) _m analgesics & antipyretics1 a mixture ( v>i\s coal-t> d]ivatives0 & z 8! safe/ & be/ ( all s$atives40 ,! dose recomm5d$ 9 mo/ cases is #bj gra9s--equal to #aj gra9s ea* ( acetanilid & potassium bromid4 ,s9ce ! ,food & ,drugs ,act has gone into effect its label /ates t x is 8a p]fect comb9ation ( a ph5ol & brom9 d]ivative conta9+ #bhb gra9s ( acetph5etid91 ,u4 ,s4 ,p41 p] ounce40 ,:at a boon x 0 to m5daci\s manufactur]s t ! pat5t rights on ph5acet9 expir$ be=e ! ,food & ,drugs ,act w5t into effect4--7,ab/ract$ f ,! ,j\rnal ,a4 ,m4 ,a41 ,july #ad1 #aijf1 & ,april #ah1 #aijh47 ,,ph5olph?ale9 ,ph5olph?ale9 has long be5 us$ z an indicator 9 *emical reactions1 b its use z a !rapeutic ag5t#aae is comp>atively new4 ,:5 its laxative prop]ties 7 fir/ discov]$ x 0 exploit$ z a propriet>y 9 ,g]many1 & x 0 n long be=e ! ent]pris+ manufactur]s 9 ?is c\ntry saw 9 x a pot5tial gold m9e & n[ ne>ly e propriet>y drug manufactur] 9 ?is c\ntry has co9$ a propriet>y "n = x & is exploit+ x1 ei!r alone or 9 comb9ation ) "o or m o!r laxatives1 & ) m or less unw>rant$ claims4 #aae ,^? :o wi% to /udy ! action & use ( ?is drug fur!r w f9d ref]5ces to articles 9 ,! ,j\rnal z foll[s3 ,! ,j\rnal1 ,jan4 #e1 #aijg1 pp4 #fd & #gj2 ,m>* #cj1 #aijg1 p4 #aacc2 ,april #bj1 #aijg1 p4 #acea2 ,nov4 #ba1 #aijh1 p4 #aghb2 ,nov4 #bh1 #aijh1 p4 #ahhf4 ,! fir/ page m5tion$ discusses ! introduction ( ph5olph?ale9 into m$ic9e4 ,ph5olph?ale9 itself has c]ta9 pretty well def9$ prop]ties1 b :5 a little ( "s o!r drug has be5 add$ wond]ful !rapeutic possibilities are claim$ = ! comb9ation4 ,! drug also has a def9ite m>ket value & ! pure sub/ance 9 ! =m ( p[d]1 tablets or pills c\ld n be sold at a price greatly 9 excess ( ! m>ket value4 ,?us manufactur]s1 f bus9ess policy1 add to x o!r drugs4 ,!re are n[ on ! m>ket num]\s m or less secret & 8fancy0 prep>ations ( ph5olph?ale9 = :i* a price is *>g$ out ( all proportion to ! value ( ! prep>ation4 ,among ^! are3 ,ph5olph?ale9 ,laxative 7,el ,z]nac ,co474 ,exurg9e 7,bis*(f ,co474 ,probil9 7,s*]+ ,glatz74 ,prunoids 7,sultan ,drug ,co474 ,lax9e 7,columbus ,ph>macal ,co474 ,ph5olax ,waf]s 7,upjohn ,co474 ,laxaph5 7,p>ke1 ,davis ,co474 ,ph5ale9 7,pax ,*emical ,co474 ,?alos5 7,abbott ,alkaloidal ,co474 ,laxo?al5 ,tablets 7,pitman-,my]s ,co474 ,v]acolate 7,m>cy ,co474 ,& additional prep>ations are /ill com+ out6 ,"s ( ! prep>ations conta9 only ! ph5olph?ale9 ) a co9$ non-descriptive propriet>y "n atta*$1 b mo/ ( !m conta9 9 addition "o or m ( su* drugs z casc>a1 sulphur1 prune1 s5na1 salicylic acid1 ipecac & aromatics4 ,! exploitation ( ph5olph?ale9 9 ?is way gives opportunity to ! manufactur]s to make all sorts ( /rong claims1 "s ( !m directly contradictory1 = _! prep>ations4 ,= in/ance1 ,ph5olax1 :i* is said to conta9 ph5olph?ale9 & cane sug>1 is claim$ to be 8a great success = all =ms ( con/ipation1 inte/9al atony & hepatic torpor40 ,( ,laxo?al51 :i* is said to conta9 ph5olph?ale91 aromatics & sug>1 x is /at$ t 8its action is conf9$ to ! b[el & x has practically no hepatic action40 ,( ,prunoids1 :i* is said to conta9 ph5olph?ale91 casc>a1 de-emetiz$ ipecac & prunes1 we h ! old famili> /atem5t t 8! h>moni\s bl5d+ ( ! sev]al +r$i5ts w give results t _c be obta9$ ?r\gh _! use sep>ately1 nor w _! use be foll[$ by aft]-con/ipation40 ,at ! "t ph5olph?ale9 0 beg9n+ to be exploit$ 9 ?is c\ntry ,! ,j\rnal#aaf sugge/$ t physicians :o wi%$ to try ! rem$y %\ld prescribe x "u its own "n & n "u fancy1 co9$ names4 ,s9ce ph5olph?ale9 occurs 9 ! =m ( an insoluble & ta/eless p[d] !re is no reason :y special ph>maceutical prep>ations ( x %\ld be plac$ on ! m>ket4 ,x c be prescrib$ 9 p[d] =m1 9 pills1 capsules or tablets4 ,?us giv51 ! true !rapeutic action ( ! drug w\ld be app>5t & its actual value arriv$ at4 #aaf ,! ,j\rnal1 ,m>* #cj1 #aijg1 p4 #aacc4 ,! vice ( ?is unsci5tific habit ( prescrib+ names in/ead ( drugs is /at$ 9 a =cible way 9 a lett] receiv$ f ,dr4 ,v4 ,e4 ,simpson1 a tea*] ( mat]ia m$ica & !rapeutics 9 ! m$ical dep>tm5t ( ! ,univ]sity ( ,l\isville4 ,he says3 8,rec5tly ,p4 ,d4 ,co4's repres5tative left on my desk a sample label$ #8,laxaph54' ,! =mula giv5 is3 ph5olph?ale91 gr4 viii2 salicylic acid1 gr4 #c_/e1 9 ea* fluid\nce1 #8incorporat$ 9 a palatable *ocolate base4' ,n[1 9 ! fir/ place1 ?is "n is "o t ! public w easily le>n & w soon call =2 9 ! second place1 x is n a "n t c>ries ) x ev5 a sugge/ion ( its cont5ts2 &1 f9ally1 ! physician acquires ! habit ( me*anically prescrib+ names in/ead ( drugs1 & 9 ! burd5+ ( 8 memory ) ! myriad ( fanta/ic label+s he f9ds x impossible to rememb] ev5 ! drugs any "o conta9s1 mu* less ! exact proportions ( ^? drugs4 ,!n suppose t a consultation is _h2 ! consultant asks :at is be+ giv5 & ! att5dant answ]s t he is giv+ #8laxaph54' ,! consultant1 p]haps1 has n be5 sampl$ & inquires ab\t x2 ! att5dant mu/ answ]4 #8,oh1 x conta9s "s ph5olph?ale9 & a salicylate1 b ,i h =gott5 ! exact proportions4 ,i h ! lit]ature on my desk4' ,_h he us$ ,u4 ,s4 ,p4 & ,n4 ,f4 rem$ies1 :i* ! consultant & e o!r doctor 9 ! l& has access to & %\ld h "s k (1 ?is emb>rassm5t w\ld n occur40 ,all ( ! above %\ld rem9d ! physician t he %\ld write simple prescriptions1 = drugs ^: action he kn[s1 adapt$ to ! p>ticul> case & n = money-mak+ comb9ations "u fanciful1 non-descriptive names exploit$ by ! propriet>y manufactur]s4 ,9 ?is way he w n only save money = himself & 8 pati5ts1 b he w be giv+ !m exact & effective treatm5t1 he w "k exactly :at he is giv+ & le>n = himself its effect1 & he w be foll[+ ! only me?od :i* entitles him to be call$ a sci5tific physician4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,april #cj1 #aiaj47 ,,mix$ ,,vacc9e ,,& ,,phylacog5s,,ay ,,ay ,a repr9t ( articles on ! subject ( ,phylacog5s orig9ally publi%$ 9 ,! ,j\rnal is issu$ "u ! title 8,! ,phylacog5s3 ,a ,m5ace to ,rational ,!rapy40 ,! not$ advance 9 !rapeutics %[n 9 ! developm5t ( vacc9e !rapy has br\ght ) x grave dang]s z well z advantages4 ,we h1 on a numb] ( occasions1 discuss$ 9 special articles & 9 editorials ! dang]s :i* ?reat5$ f ! rapid comm]cialization ( ?is new me?od4 ,! unsci5tific "* ( mix$ vacc9es & ( ! mix$ filt]$ products ( a numb] ( vacc9es m>ket$ z 8,phylacog5s0 has be5 especially emphasiz$ & ! dang] f _! indiscrim9ate use po9t$ out4 ,a little ov] a ye> ago we publi%$ a s]ies ( articles deal+ ) ! :ole subject 9 :i* ! nature ( mix$ vacc9es 0 describ$#aag z foll[s3 #aag ,bact]ial ,vacc9e ,!rapy3 ,its ,indications & ,limitations1 p4 #cg1 repr9t$ f ,! ,j\rnal ,a4 ,m4 ,a41 ,april #bf ,june #bh1 #aiac1 price #aj c5ts4 8,! mix$ /ock vacc9e ( comm]ce is a make%ift4 ,x is (f]$ z a sub/itute = correct diagnosis4 ,l all su* make%ifts 9 sci5ce1 x is doom$ to failure4444 ,a burd5 is be+ =c$ on ! pr(ession :i* w spe$ily assume ! proportions atta9$ by propriet>y drug comb9ations4 ,! m5ace _c be c\nt]act$ unless physicians w accept ! guidance ( unselfi%1 non-comm]cial int]e/s & refuse to pur*ase & use mix$ comm]cial vacc9es40 ,?is admonition to seek ! guidance ( unbias$ sci5tific obs]v]s is des]v+ ( special emphasis at ! pres5t "t4 ,five weeks ago we publi%$ ! address ( ! *airman ( ! ,section on ,ph>macology & ,!rapeutics1 ,dr4 ,john ,f4 ,&]son1#aah "o ( our =emo/ work]s 9 ?is bran* ( biologic sci5ce1 9 :i* att5tion 0 v =cibly drawn to ! dang]s involv$ 9 ! use ( biologic products ( non-specific "*4 ,he says3 #aah ,&]son1 ,john ,f43 ,"s ,unheal?y ,t5d5cies 9 ,!rapeutics1 ,! ,j\rnal ,a4 ,m4 ,a41 ,july #d1 #aiad1 p4 #a4 8,bact]ial !rapy und\bt$ly 9 "s cases is a mo/ valuable me?od ( treatm5t2 b :5 ! claim is made t a comb9ation ( ! dead bodies or ! filt]$ products ( a numb] ( diff]5t bact]ia are useful = ! treatm5t ( c]ta9 diseases ) a diff]5t specific cause1 x w\ld seem t ! sugge/ion closely approa*es quack]y40 ,fur!r he says3 8,aside f ! d\btful practice ( ! indiscrim9ate use ( unprov$ me?ods ( treatm5t1 x has seem$ to me t a great inju/ice is done ! pati5t by _! use1 s9ce "s ( ! prep>ations t h be5 widely exploit$ h be5 %[n to be h>mful 9 c]ta9 in/ances & ev5 to h caus$ dea?4 ,s ! fir/ /ep 9 attempt+ to rem$y conditions is to awak5 ! physician to ! importance ( ignor+ ! claims ( ^? :o are pu%+ ^! new me?ods until _! usefulness & h>mlessness has be5 cle>ly demon/rat$ by ^? be/ 9 a position to d s40 ,z a result ( sci5tific me?ods 9 tea*+ !rapeutics1 physicians h gradually giv5 up almo/ entirely ! use ( 8%otgun0 prescriptions & n[ prescribe a drug or a comb9ation ( a few drugs1 ea* giv5 = ! purpose ( ex]t+ a def9ite action4 ,on ! o!r h&1 ! purveyors ( bact]ial vacc9es h gradually increas$ ! numb] ( diff]5t bact]ia 9 _! mix$ vacc9es until "s ( ^? n[ adv]tis$ = sale conta9 z _m z sev5 diff]5t k9ds ( bact]ia1 & "s ( ! 8,phylacog5s0 conta9 ! filt]$ products ( at lea/ elev5 bact]ial species6 ,"u ! pres5t f$]al laws !re does n seem to be any way 9 :i* ! f$]al gov]nm5t c d m ?an is be+ done at pres5t4 ,x is a case 9 :i* ! physician becomes ! sole gu>dian ( ! pati5t committ$ to 8 c>e4 ,he is ! "o & ! only responsible individual4 ,he _c ?r[ ! blame = bad results back to ! manufactur]4 ,:5 he subjects 8 pati5t to ! possibility ( h>m by ! use ( ^! unsci5tific & dang]\s prep>ations1 ! physician assumes ! responsibility1 :e!r he wants to or n4 ,if physicians w\ld report _! failures :5 ^! vacc9es are us$1 & especially report ! fatalities consequ5t on _! use1 ) ! "n ( ! manufactur] ( ! p>ticul> product us$1 we are q sure !re w\ld result less5+ 9 ! en?usiasm ( ! purveyors ( ^! products4 ,:5 tempt$ by ! optimi/ic /atem5ts ( ! int]e/$ manufactur] ( ^! mixtures to give !m a trial ! physician %\ld rememb] t ! w>n+s ( dis9t]e/$ sci5ti/s are ( f> m value ?an uncritical cl9ical reports put out "u comm]cial auspices4 ,?is we quote f a rec5t book by ,victor ,c4 ,vaughan1#aai ,presid5t ( ! ,am]ican ,m$ical ,association3 #aai ,vaughan1 ,victor ,c43 ,prote9 ,split ,products 9 ,relation to ,immunity & ,disease1 #aiac1 p4 #bbf4 8,e "t an unbrok5 prote9 is introduc$ into ! body x c>ries ) x1 & z a "p ( x1 a poison4 ,f ! v c>eless1 ra%1 & unw>rant$ way 9 :i* #8vacc9es' ( mo/ div]se orig9 & composition are n[ us$ 9 ! treatm5t ( disease1 ?is matt] c]ta9ly _c be und]/ood or its dang] appreciat$ by ^? :o subject _! pati5ts to su* risk4 ,x %\ld be cle>ly und]/ood t all prote9s conta9 a poison\s gr\p--a sub/ance :i* 9 a dose ( #j4e mg4 inject$ intrav5\sly kills a gu9ea-pig4 ,?is poison is pres5t 9 all ! s-call$ #8vacc9es' n[ s l>gely us$1 & x is n /range t dea? occasionally foll[s ! use ( #8,phylacog5' or simil> prep>ations4 ,n only d ^! prote9s conta9 a poison1 b :5 introduc$ p>5t]ally ! poison is set free1 n 9 ! /oma*1 f :i* x may be remov$1 b 9 ! blood & tissues4 ,x is possible t vacc9e !rapy may become ( great s]vice 9 ! treatm5t ( disease4 ,ev5 n[ !re are occasional brilliant results :i* are report$ :ile ! failures & disa/]s are n s widely adv]tis$40 ,su* a w>n+ z ?is quotation conta9s1 f a man s em95t z ,dr4 ,vaughan1 m]its & %\ld receive ! c>eful att5tion ( m$ical m52 at lea/ x %\ld h z mu* weight z ! 8cl9ical evid5ce0 spread broadca/ among our pr(ession by comm]cial h\ses4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,aug4 #bi1 #aiad47 ,,! ,,dang] ,,9 ,,protonucle91 ,a ,,prep>ation ,,conta9+ ,,?yroid ,protonucle9 0 ! subject ( a little article 9 our ,qu]ies & ,m9or ,notes ,dep>tm5t1 ,nov4 #af1 #aiab1 page #ahab4 ,dr4 ,reid ,hunt1 ,wa%+ton1 ,d4 ,c41 writes3 8,to ! ,editor3--,i h be5 reque/$ by a physician to call y\r att5tion to c]ta9 /atem5ts :i* might well h be5 add$ to y\r reply to ,j4 ,a4 ,c4 9 reg>d to ,protonucle94 ,dr4 ,seidell & ,i exam9$ sev]al samples ( ,protonucle9 "s "t ago#abj & by *emical & physiologic te/s f\nd t !y conta9$ ! equival5t ( #aj p] c5t4 ?yroid ( #j4a p] c5t4 iod9 /r5g? 7! actual am\nt ( ?yroid may h be5 great] or less = we did n "k ! p]c5tage ( iod9 9 ! ?yroid us$74 ,! dose recomm5d$ on ! bottle 0 #f to #ab gra9s e ?ree or f\r h\rs2 ?is repres5ts f #j4f to #a4b gra9s ( "s ( ! comm]cial ?yroid p[d]s1 & is suffici5t to cause pron\nc$ ?yroid effects 9 _m conditions4 ,protonucle9 0 adv]tis$ z a #8p]fectly h>mless antitox91 tissue-build]1' etc41 al?\gh ! dose ( ?yroid did n diff] mat]ially f t 9 #8,r5go' & #8,m>mola1' two anti-fat no/rums :i* we exam9$ at ! same "t4 ,we call$ att5tion to ! dang] ( us+ ?yroid1 ! mo/ p[]ful tissue-de/roy+ drug kn[n1 9 cases ( typhoid1 ph?isis1 etc41 = :i* protonucle9 0 recomm5d$1 ?\gh ^! are conditions 9 :i* ! physician is suppos$ to be ex]t+ e ef=t to build up ! tissues4 #abj ,hunt1 ,reid1 & ,seidell1 ,a!rton3 ,comm]cial ,?yroid ,prep>ations & ,sugge/ions z to ! ,/&>dization ( ,?yroid1 ,! ,j\rnal ,a4 ,m4 ,a41 ,oct4 #bd1 #aijh1 p4 #ache4 8,y also speak ( ! #8high' nucle9 cont5t 7#j4bh p] c5t4 phosphorus73 ! l>ge/ recomm5d$ dose w\ld conta9 only ab\t #a_/c gra9 ( nucleic acid--an am\nt :i* probably has n ! slighte/ effect1 especially :5 giv5 by ! m\?4 8,a sample ( #8,protonucle9 ,special' 0 f\nd to h twice z mu* ?yroid z ! ord9>y ,protonucle92 ?is also 0 /at$ to be #8p]fectly h>mless4'0--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,feb4 #a1 #aiac47 ,,purg5 ,! physicians ( ! ,unit$ ,/ates are receiv+ a neat package conta9+ samples ( a ,g]man propriet>y--,purg54 ,! conta9] is an +5i\s "o &1 besides ! tablets1 includes a circul> 9 ,engli%1 al?\gh mail$ 9 ,europe1 describ+ ! rem>kable virtues ( ?is 8new syn!tic ap]i5t40 ,x has be5 consid]$ /range t ?is propriet>y1 :i* has be5 adv]tis$ s ?or\ghly 9 ,europe1 ,au/ralia1 etc41 %\ld n h made its appe>ance 9 ?is c\ntry4 ,n[ x is "h1 & x is well t physicians %\ld "k :at ,purg5 is & n be my/ifi$ & misl$ by ! lit]ature t !y may receive reg>d+ ! prep>ation4 ,! foll[+ appe>$ 9 ,! ,j\rnal1 ,jan4 #e1 #aijg1 page #fd1 & is repr9t$ n[ z be+ especially timely3 ,! report ( a case ( poison+ by ,purg5 7ph5olph?ale97 is ! occasion = "s p]t95t obs]vations by ,dr4 ,g4 ,bras* z to ! prop] introduction ( su* rem$ies to ! m$ical pr(ession 7,zts*rift fr ,m$iz9albeamte1 ,ab/4 9 ,apo!k]-,zeitung1 ,no4 #ei1 #aijf74 ,he agrees ) ,be/ t all su* rem$ies %\ld fir/ receive a ?or\gh trial 9 an in/itution subject to /ate sup]vision1 be=e !y are adv]tis$ to ! m$ical pr(ession1 s t _! h>mlessness 9 appropriate doses may be asc]ta9$ by a me?od free f liability to error4 ,! mann] 9 :i* ! manufactur]s introduc$ ,purg5 to ! pr(ession & ! laity is to be condemn$1 & probably l$ to ! symptoms ( poison+ exhibit$ 9 ! case ( ,dr4 ,be/ & t5ds to discr$it a rem$y :i* is h>mless & effici5t if us$ 9 prop] doses4 ,! manufactur] ( su* a prep>ation is incl9$1 = obvi\s reasons1 to put ! dose ( 8 prep>ation mu* too high4 ,! mo/ important po9t1 h[ev]1 is ! objectionable "* ( ! names giv5 to su* articles4 ,! organic comp\nd ph5olph?ale9 has be5 kn[n = a long "t & has be5 widely us$ z an indicator4 ,accid5tally x 0 discov]$ t ph5olph?ale9 possess$ laxative prop]ties & !reon x 0 propos$ 7#aija7 z a m$ic9e "u ! "n 8,purg540 ,x is sold 9 tablets conta9+ #j4je1 #j4a & #j4e gra9 ph5olph?ale9 mix$ ) sug> & flavor$ ) vanilla4 ,! au?or says3 8,b x is v desirable--& ,i reg>d ?is z ! mo/ important "p ( my communication--t ph5olph?ale9 %\ld be receiv$ into ! mat]ia m$ica "u its own "n4 ,! addition ( vanilla & sug> is to ! highe/ degree sup]flu\s & ! arbitr>y dosage 9 ?ree /r5g?s ) ! ridicul\s designations1 #8baby1' #8= adults1' #8= pati5ts conf9$ to b$1' are m]ely calculat$ to prejudice ! physician :o is accu/om$ to individualize 9 8 prescriptions1 aga9/ a rem$y :i* is 9 itself an excell5t "o40 ,z explanatory to ! la/ s5t5ce1 x %\ld be /at$ t 9 ,europe ,purg5 is put up 9 ?ree dosage =ms1 8infant ,purg5 = *ildr510 conta9+ #c_/d ( a gra92 8adult ,purg5 = *ronic con/ipation10 conta9+ #a-a_/b gra9s1 & 8/rong ,purg5 = invalids10 conta9+ #g-a_/b gra9s4 ,! =m 9 :i* x is be+ sampl$ 9 ?is c\ntry is 9 ! m$ium dose1 #a-a_/b gra9s4 ,physicians %\ld rememb] t ! promot]s ( ,purg5 are simply introduc+ a *emical well kn[n to laboratory work]s = ! la/ tw5ty ye>s1 :i* has be5 recogniz$ z an ap]i5t = at lea/ sev5 ye>s1 & :i* c be pur*as$ = #dj c5ts an ounce1 :]eas an ounce ( ph5olph?ale9 9 ! =m ( ,purg5 w co/ #c4bj :olesale4 ,! en?usia/ic praise ( ! rem$y1 f\nd 9 ! adv]tis+ circul>s1 %\ld be subject$ to critical judgm5t on acc\nt ( its s\rce & motives4 ,x is und\bt$ly true1 h[ev]1 z we h previ\sly /at$1 t ph5olph?ale9 is wor?y ( a trial4 ,9 ! ,briti% ,m$ical ,j\rnal1 ,oct4 #ah1 #aijb1 ,f4 ,w4 ,tunnicliffe speaks ( ! virtues ( ph5olph?ale91 & ! conclusions rea*$ by him 7 t x is a useful ap]i5t1 )\t irritat+ action on ! kidneys1 & is especially valuable 9 jaundice1 its depress+ action on ! circulation be+ less ?an sulphate ( magnesia4 ,ph5olph?ale9 is n 9 ! ,ph>macopeia1 b has be5 includ$ 9 8,new & ,non(ficial ,rem$ies0 by ! ,c\ncil on ,ph>macy & ,*emi/ry4 ,f ?is we quote3 ,actions & ,uses4--,ph5olph?ale9 acts z a purgative1 b appe>s to possess no fur!r physiologic action4 ,a case ( poison+ f tak+ #a gm4 7#ae gra9s7 is report$4 ,dosage4--,= adults ! av]age dose is #j4a to #j4b gm4 7#a4e to #c gra9s7 giv5 z p[d]1 9 ca*ets1 capsules or pills4 ,x may be giv5 ) safety 9 doses ( #j4e gm4 7#h gra9s71 & ^! doses seem to be necess>y to secure its effects 9 b$ridd5 pati5ts or 9 ob/9ate cases4 ,we h gone into ?is matt] aga9 s t our read]s may h "s k ( ?is rem$y1 & we hope t if !y conclude to try x !y w use ! *emical itself & "u its own "n4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,sept4 #ad1 #aijg47 ,,pyo-,,atox9 8,to ! ,editor3--,i am s5d+ y a sample ( a propriet>y prep>ation t = ! pa/ two or ?ree ye>s has be5 l>gely retail$ 9 ! ,s\? & ,s\?we/ z a new comb9ation t lib]ates l>g] am\nts ( =maldehyd1 etc41 9 ! g5ito-ur9>y tract ?an any kn[n ag5t1 t x is a me?yl5e-=mate1 entirely new1 etc4 8,i ask$ ! repres5tative :y he _h n submitt$ a specim5 to ! ,c\ncil1 & 8 reply 0 t l ,wye? & o!rs !y did n get a fair report1 or some?+ to ?is effect4 ,my reasons = try+ to f9d ! tru? = _! claims is t q a numb] ( g5]al practition]s h ask$ me reg>d+ ?is ,pyo-,atox94 8,w4 ,p4 ,dey1 ,m4,d41 ,jacksonville1 ,fla40 ,dr4 ,dey s5t ) ! =ego+ lett] a box ( ,pyo-,atox9 :i* bore ?is label3 ,pyo-,atox9 ,reg4 9 ,u4 ,s4 ,pat4 ,(fice 7,capsules7 7,ph5o-,me?yl5e-,=mate7 8,hurley0 ,an ,antitoxic ,ag5t ,indicat$ 9 ,gonorrhoea1 ,cy/itis1 ,pyelitis & ,bact]iuric ,conditions4 ,,dose3 ,"o capsule f\r to six times daily1 ,foll[$ by l>ge glass ( wat]4 ,gu>ante$ by ,h4 ,o4 ,hurley1 ,manufactur+ ,ph>maci/1 ,l\isville1 ,ky4 ,"u ! ,food & ,drugs ,act1 ,june #cj1 #aijf ,s]ial ,no4 #agaj4 ,! pseudosci5tific synonym 8ph5o-me?yl5e-=mate0 c>ries ! idea t ,pyo-,atox9 is a def9ite *emical sub/ance4 ,x is unnecess>y to say t ! t]m 8ph5o-me?yl5e-=mate0 is a mean+less "o & its use rem9ds "o ( ^? prep>ations exploit$ sev5 or eight ye>s ago be=e ! ,c\ncil began to expose ^! mixtures masqu]ad+ z def9ite *emical comp\nds4 ,! *emical laboratory 0 ask$ to inve/igate ?is prep>ation & ! foll[+ is a report ( ! *emi/s3 8,! box conta9$ ?irty gelat9 capsules coat$ ) "s black sub/ance giv+ !m ! appe>ance ( "s ( ! popul> gonorrhea no/rums4 ,:5 ! capsules 7 op5$ !y 7 f\nd to conta9 a p[d]--ab\t #j4ce gm4 or #e gra9s p] capsule--compos$ ( l>ge :ite or colorless cry/als mix$ ) a small] am\nt ( a f9e d>k p[d]4 ,! cry/als :5 sep>at$ out & dissolv$ yield$ ! *>act]i/ic te/s = hexame?yl5am94 ,a solution ( ! entire capsule cont5t 0 deep blue & respond$ to ! ,u4 ,s4 ,p4 te/s = me?yl5e blue4 8,z a result ( ^! & o!r te/s x 0 conclud$ t ,pyo-,atox9 consi/$ ess5tially ( two ph>macopeial drugs--hexame?yl5am9 & me?yl5e blue4 ,a quantitative det]m9ation ( ! con/itu5ts 0 consid]$ unnecess>y4 ,f its g5]al appe>ance & prop]ties1 h[ev]1 ! hexame?yl5am9 probably con/itutes approximately f #fj to #hj p] c5t4 ( ! prep>ation40 ,x ?us appe>s t ! capsules conta9 a mixture consi/+ ess5tially ( two well-kn[n (ficial sub/ances1 ! value & p>ticul>ly ! limitations ( :i* %\ld be kn[n by physicians by ?is "t4 ,?is no/rum is simply ano!r example ( h[ physicians are be+ humbugg$4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,feb4 #ad1 #aiad47 ,,res9ol ,! ,philadelphia bran* ( ! ,am]ican ,ph>maceutical ,association issu$ a pamphlet "s two ye>s ago 9 :i* ! foll[+ appe>$ relative to ,res9ol & simil> products3 ,illu/ration 8,)9 rec5t ye>s !re h be5 introduc$ a numb] ( comp\nd o9tm5ts t 9 _! suppos$ range ( !rapeutic usefulness are sc>cely equal$ & c]ta9ly n excell$ by ! magic ungu5ts ( ! quacks & *>latans ( cont95tal ,europe1 :o1 sev]al c5turies ago1 essay$ to cure all mann] ( disease by inunction or ! simple application ( comp\nd o9tm5ts ( secret composition4 8,z typical ( ?is mod]n class ( panaceas we may m5tion ,res9ol4 ,?is prep>ation is be+ widely adv]tis$ at ! pres5t "t 9 ! daily pap]s z a valuable adjunct to ,res9ol ,soap 9 ! treatm5t ( all k9ds & v>ieties ( diseases ( ! sk94 ,! mak]s ( ?is p>ticul> mixture1 9 ! =m ( an o9tm5t1 mode/ly ass]t t x w cure all sk9 diseases1 & is also #8,specific = ,pruritus ,ani1 ,it*+ ,piles1 & ,pruritus ,vulv4'0--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #f1 #aiji47 ,,resor-,,bisnol ,resor-,bisnol 0 consid]$ by ! ,c\ncil & refus$ recognition4 ,! foll[+ =mula = ,resor-,bisnol 0 at "o "t giv5 9 adv]tisem5ts 9 a numb] ( m$ical j\rnals3 8,a sci5tific comb9ation1 9 nicely balanc$ proportions ( ,bismu? ,salts ( antiseptic acids ( ! aromatic s]ies1 & ,resorc94 8,ea* #ajj p>ts conta9s #bj p>ts ,resorc91 & #eb p>ts ,bismu? ,oxid1 comb9$ ) antiseptic acids40 ,besides ?is =mula o!r 8=mulas0 equally indef9ite1 vague & mislead+ h be5 giv5 9 lieu ( an actual /atem5t ( composition1 ?us3 8---- is a mixture ( resorc9 & bismu? salts ( ph5ic acids su* z salicylates1 etc41 & an aromatic alcoholate4 ,its composition is z foll[s4 ,bismu? salts ( ph5ic acids #fj p] c5t4 ,aromatic alcoholate ( bismu? #bj p] c5t4 ,resorc9 #bj p] c5t40 ,! product 0 rec5tly analyz$ 9 our *emical laboratory4 ,! *emi/s report z foll[s3 8,a specim5 ( ,resor-,bisnol exam9$ by u consi/$ ( a light br[n p[d] possess+ a *>act]i/ic odor & a ta/e at fir/ sweeti% & !n bitt]4 ,x 0 f\nd to be only p>tially soluble 9 wat]4 ,! exam9ation indicates t ,resor-,bisnol is probably a mixture consi/+ ess5tially ( a basic bismu? salicylate 7bismu? subsalicylate71 a basic gallate ( bismu? 7bismu? subgallate71 a basic comp\nd ( beta-naph?ol 7bismu? betanaph?olate7 & resorc9ol 7resorc9740 ,x ?us appe>s t ,resor-,bisnol is probably a simple mixture ( well-kn[n sub/ances4 ,9 o!r words1 ! ,resor-,bisnol adv]tis+ & lit]ature are typical ( t issu$ by v>i\s no/rum h\ses3 x conceals ! tru? 9 a mass ( semi-sci5tific v]biage1 & :ile n frankly false1 x deceives by :at is left unsaid r ?an by :at is said4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,june #a1 #aiab47 ,,rob9ol ,,& ,,sevetol ,revamp+ ,disc>d$ ,!ories = ,comm]cial ,purposes ,x is a/oni%+ h[ rapidly m$ical hypo!ses become !ories & !ories are accept$ = e/abli%$ facts1 :5 su* alleg$ facts are favorable to comm]cial ent]prise4 ,yet1 z a matt] ( fact1 ! manufactur]s ( propriet>y prep>ations are "u a moral obligation1 at lea/1 to tell ! tru? ) ref]5ce to ! sci5tific basis = _! claims4 ,to draw f explod$ !ories reasons = ! use ( propriet>y prep>ations is repreh5sible1 n only because x may lead physicians to use prep>ations :i* are wor?less1 b also because x t5ds to confirm 9 ! physician's m9d op9ions :i* sci5ce has disc>d$4 ,rob9ol ,john ,wye? & ,bro!r put up a mixture ( glyc]ophosphates :i* !y call ,rob9ol4 ,9 _! description ( ! prop]ties ( ?is mixture !y say3 8,phosphorus exi/s 9 ! bra91 n]v\s sy/em1 & vital organs z leci?91 ( :i* glyc]ophosphoric acid is ! mo/ important con/itu5t & is ess5tial to ! vital processes = ! reproduction ( life & ma9t5ance ( metabolism 9 old age1 impot5ce1 etc40 ,! fir/ impression on read+ ?is s5t5ce is t x sugge/s t glyc]ophosphates are ess5tial to ! vital processes1 al?\gh ! /atem5t /rictly applies to phosphorus4 ,! next s5t5ce confirms ?is impression & ! m9d glissades f ! accept$ fact ( ! exi/5ce ( phosphorus 9 n]v\s tissue to ! unf\nd$ hypo!sis t ! glyc]ophosphates are necess>y to supply ! ess5tial elem5t4 ,9 ! next s5t5ce ! circul> cont9ues3 8,9 n]v\s & g5]al debility ! glyc]ophosphates z exhibit$ 9 ,rob9ol1 are pref]able to ! m9]al phosphates z !y contribute ! ess5tial con/itu5t ( n]ve tissue & are absorb$ by ! cells m readily ?an any phosphate ( vegetable or inorganic orig940 ,?is /atem5t is utt]ly unf\nd$4 ,x is 9 direct opposition to ! conclusions ( ph>macologi/s4 ,! glyc]ophosphoric acid radical is1 to be sure1 f\nd 9 ! leci?9 ( n]v\s tissues1 b its s\rce is n kn[n4 ,!re is no evid5ce ei!r t x mu/ be pres5t 9 ! food or t x mu/ be tak5 z m$ic9e 9 ord] t ! bra9 & n]v\s tissues %all be n\ri%$4 ,:5 ! glyc]ophosphates are tak5 !re is no evid5ce t !y ent] into ! composition ( ! bra9 or n]v\s tissue4 ,!y are excret$ 9 ! ur9e & feces z phosphates4 ,x has nev] be5 %[n t glyc]ophosphates are absorb$ any m readily ?an o!r phosphates4 ,b ! adv]tis+ circul> has /ill m in=mation to imp>t to physicians3 8,9 t gr\p ( maladies *>act]iz$ by faulty nutrition1 due to ! excessive elim9ation ( phosphorus f ! body1 z is evid5c$ by ! fatigue & weakness foll[+ acute attacks & pres5t 9 _m *ronic affections1 dur+ ! c\rse ( fev]s & 9 ! lat] /ages ( ph?isis & all diseases ( ! n]v\s sy/em1 physicians w f9d ! tonic *alybeate prop]ties ( ! glyc]ophosphates ( great value40 ,physicians "k1 if ! no/rum mak]s d n1 h[ difficult x is to det]m9e :e!r !re is an excessive elim9ation ( phosphorus f ! body4 ,! bulk ( ! phosphates f\nd 9 ! ur9e are d]iv$ f ! food & s little comes f ! metabolism ( ! n]v\s sy/em t x is n easy to prove t any disease is due to excessive elim9ation ( phosphorus f ! body4 ,t fatigue & weakness are due to su* a loss ( phosphorus is m]e assumption1 a conv5i5t !ory = ! exploit]s ( glyc]ophosphates4 ,b admitt+ t n]v\s wa/e or faulty nutrition is *>act]iz$ by ! loss ( phosphorus1 x is easi]1 *eap] & m rational to supply su* loss by ! use ( phosphorus-conta9+ foods1 su* z milk & eggs1 & !re is n ! slighte/ evid5ce t ! loss ( phosphorus w be influ5c$ 9 any way by giv+ a supply 9 ! =m ( glyc]ophosphates4 ,?us1 9 ord] to bol/] up ! sale ( a simple solution ( glyc]ophosphates1 vague !ories & improbable hypo!ses are dress$ 9 all ! dignity ( sci5tific facts4 ,sevetol ,!re 0 a "t1 p]haps a g5]ation ago1 :5 physiologi/s taught t fats 7 absorb$ into ! blood 9 ! =m ( a f9e emulsion4 ,?is !ory has be5 def9itely disprov$ & x is n[ kn[n t fats ent] ! blood only aft] a *emical splitt+ into glyc]ol & fatty acids1 ! latt] be+1 to a l>ge ext5t1 comb9$ ) alkalies 9 ! =m ( soaps4 8,sevetol10 ano!r ,wye? prep>ation1 is pres5t$ to ! pr(ession "u ! claim t x is a v f9e emulsion ( fats1 e portion ( :i* 8is readily absorb$ ?r\gh ! inte/9al wall40 ,to quote3 8,! adm9i/ration ( ,sevetol1 !re=e1 does n tax ! dige/ive p[] ( ! pati5t1 = x is absorb$ ) v little ef=t on ! "p ( ! dige/ive app>atus2 & ev5 if ! organs ( dige/ion be involv$1 nei!r ! weakness ( ! pati5t nor ! sev]ity ( ! symptoms necess>ily contra-indicates its use4 ,! am\nt +e/$ is limit$ only by ! p[] ( assimilation exhibit$ 9 ! tissues1 & x may be giv5 9 l>ge doses = a cont9u$ p]iod ( "t1 or until symptoms ( ov]fe$+ are produc$1 su* z coat$ tongue1 anorexia1 con/ipation1 heada*e & lassitude4 ,:5 ^! symptoms appe>1 ! adm9i/ration ( ,sevetol %\ld be tempor>ily discont9u$ & a mild b effective laxative giv5 = sev]al days1 aft] :i* its use may be resum$40 ,:ile ! language j quot$ is a little m exalt$ & dignifi$ ?an t f\nd 9 typical 8pat5t m$ic9e0 adv]tisem5ts1 ! ?\ght x expresses qualifies x = a place 9 ! 8,lydia ,p9kham0 or 8,p]una0 class4 ,e sophomore m$ical /ud5t kn[s1 if he gives ! matt] any ?\ght1 t ,sevetol mu/ und]go ! same process ( dige/ion z any o!r fat4 ,x mu/ be brok5 up into a fatty acid & glyc]ol1 & saponifi$ be=e x c be absorb$4 ,x is pla9ly evid5t t ! am\nt ( ,sevetol :i* c be tak5 is limit$ n only by ! p[] ( assimilation1 b also by ! p[] ( dige/ion4 ,! symptoms m5tion$ 9 ! adv]tisem5t & ascrib$ to ov]fe$+1 are ! symptoms1 n ( a sy/em saturat$ ) absorb$ fat1 b ( dige/ive organs rebell+ aga9/ an unusual diet4 ,! exploitation ( ,sevetol is b "o m case ( turn+ to comm]cial acc\nt an explod$ !ory4 ,isn't x ab\t "t t our pr(ession dem&$ t ! purveyors ( m$ic9al products tell ! tru?8 ,& isn't x "t1 too1 t we cease tak+ our ph>macology & !rapeutics f propriet>y manufactur]s8--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,july #d1 #aiad47 ,,salacet9 ,"s "t ago we wrote to ,messrs4 ,bell ,co41 call+ _! att5tion to ! fact t we _h made an exam9ation#aba ( _! product1 salacet91 & t z a result ( su* exam9ation x 0 f\nd to be a mixture1 :i* did n co9cide exactly ) _! description ( x4 ,!y repli$3 8,our description ( salacet9 is correct & we h no?+ m to imp>t except t anyone publi%+ any diff]5t =mula f t giv5 9 our circul>s w be held responsible by u40 #aba ,! ,j\rnal ,a4 ,m4 ,a41 ,june #c1 #aije2 reproduc$ on page #aj ( ?is book4 ,! description !y give is z foll[s3 ,prep>$ by ! int]action1 ) heat1 ( salicylic acid1 glacial acetic acid1 & purifi$ ph5ylam9e4 ,?is s\nds v sci5tific1 b :5 we rememb] t acetanilid is a result ( ! action ( glacial acetic acid on ph5ylam9e 7anil97 _! description is cute1 to say ! lea/4 ,( c\rse1 !re is 8int]action ) heat0 :5 salicylic acid is comb9+ ) bic>bonate ( sodium to =m salicylate ( sodium4 ,fur!r1 !re is1 no d\bt1 "s 8int]action ) heat0 :5 ! sub/ances are rubb$ toge!r 9 mix+ !m & :5 !y are go+ ?r\gh ! mill to =m tablets1 n to m5tion ! heat$ imag9ation ( ! promot]s ( ?is 8syn!tic40 ,! foll[+ tak5 f ! adv]tis+ lit]ature furni%$ by ! manufactur]s & di/ribut$ by !m1 is quot$ to %[ ! claims made = ?is prep>ation3 ,salacet9 is free f ,toluod9e & produces no h>mful cyanosis4 ,9 ! treatm5t ( ,acute ,bron*itis1 ,grippe1 ,influ5za1 ,tonsillitis1 ,li!mic ,heada*es1 ,rheumatism & ,neuralgias1 x relieves pa91 r$uces inflammation & abnormal temp]ature1 & elim9ates uric acid m quickly & ?or\ghly ?an ! salicylates1 & )\t caus+ depression or /oma*ic or r5al irritation4 ,h p]sonally int]view$ ?\s&s ( physicians1 includ+ e prom95t "o 9 ! ,ea/1 & c hone/ly /ate t we h nev] kn[n ( any?+ at once s effici5t & s unobjectionable 9 ! removal ( rheumatic & neuralgic pa9 & o!r symptoms ( ! uric-acid accumulation4444 ,9 ,la ,grippe & ,acute ,bron*itis x relieves pa9 & c\gh+1 r$uces inflammation & temp]ature1 makes ! pati5t com=table1 & *ecks ! progress ( ! disease4 ,9 ,tonsillitis its action is specific4444 ,9 ,acid ,cy/itis1 x neutralizes acidity1 r$uces inflammation & removes irritation4444 ,9 ,dysm5orrhea x relieves pa9 & conge/ion ) no halluc9ations1 con/ipation or dang] ( a drug habit4 ,9 ,dysm5orrhea & ,ov>ian ,neuralgias try ,sal-,codeia--,bell4 ,x w relieve ! pa9 z well z morphia4 ,x w n *eck any secretions1 induce any habit1 cause any depression or inconv5i5ce ( any k9d4 ,( c\rse1 x is well und]/ood t acetanilid is a valuable rem$y 9 _m in/ances1 if us$ ) caution & :5 indicat$4 ,x c]ta9ly has "s !rapeutic value4 ,!re is no d\bt t x relieves pa9 ( v>i\s k9ds4 ,x is to be presum$ t comb9+ salicylate ( sodium ) x w h c]ta9 b5eficial effects 9 c]ta9 rheumatic conditions1 on ! supposition t salicylate ( sodium & acetanilid are bo? us$ ) m or less success 9 c]ta9 ( ^! conditions4 ,also1 ! comb9+ ( bic>bonate ( sodium1 c>bonate ( ammonium1 caffe91 citric acid1 "o or sev]al ( ^!1 may result 9 a fairly good comb9ation1 b ^! comb9ations c be f\nd 9 ! li/ ( prep>ations ( all our l>ge manufactur+ ph>maceutical h\ses1 :i* supply !m at "o-t5? ( ! co/ ( ^! secret rem$ies4 ,! physician 9 us+ ^! prep>ations put out by reputable recogniz$ manufactur+ ph>maceutical h\ses n only is prescrib+ prep>ations t are non-secret1 b is us+ rem$ies t co/ "o-t5? z mu* z ! secret prep>ations1 :i* are exploit$ "u fanciful names & pu%$ by ridicul\s claims4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,july #a1 #aije47 ,,sal-,,codeia--,,bell ,accord+ to ! adv]tisem5ts 8,salacet90 8444 is a comb9ation ) heat ( salicylic & glacial acetic acids ) ph5ylam9e1 ! irritat+1 depress+ & blood-corpuscle de/roy+ elem5ts remov$40 ,accord+ to ! ,committee on ,*emi/ry ( ! ,c\ncil on ,ph>macy & ,*emi/ry ( ! ,am]ican ,m$ical ,association1 ^: report 0 publi%$ 9 ,! ,j\rnal ( ! ,am]ican ,m$ical ,association ,june #c1 #aije1 p4 #agia1 8,salacet90 is a mixture ( acetanilid1 salicylate ( sodium & bic>bonate ( sodium4 ,sal-,codeia 7,salacet9-,code97 !re=e w\ld be ! same z above ) code9 add$4 ,( c\rse1 acetanilid & code9 w relieve pa9 7x c\ld n d o!rwise7 & consequ5tly make a v good comb9ation 9 c]ta9 conditions1 if n us$ too (t5 & if us$ ) c>e4 ,al?\gh ! cont9u$ use ( code9 is n likely to produce a drug habit1 x1 z well z acetanilid1 does s sometimes1 & x mu/ be rememb]$ t code9 is a motor p>alysant1 & is n ! be/ comb9ation to be us$ ) acetanilid4 ,= ^? :o wi% to give a comb9ation ( acetanilid1 salicylate ( sodium & code91 ! foll[+ prescription is sugge/$3 ,acetanilid i #d ,sodii bic>bonatis ss #b ,sodii salicylatis ss #b ,code9 sulph4 gr4 vi #d ,m4 et div4 *>t ,no4 xxiv4 ,?is w make five-gra9 p[d]s :i* may be put 9 pap]s1 capsules1 ca*ets or tablets4 ,ea* w conta9 #b-a_/b gra9s 7#j4ae gm47 ( acetanilid & #a-a_/d gra9s 7#j4jge gm47 ea* ( sodium salicylate & sodium bic>bonate1 ) #a_/d gra9 7#j4jae gm47 ( code94 ,! doses ( acetanilid & ( code9 approximate ! av]age adult doses1 b ! sodium salicylate1 to h any appreciable effect1 mu/ be increas$1 = #a-a_/d gra9s ( salicylate ( sodium 9 a dose is insignificantly small4 ,sodium salicylate ) acetanilid makes a fairly good comb9ation 9 c]ta9 rheumatic tr\bles1 b x is n indicat$ by any means z a cure-all1 z "o w\ld judge f ! lit]ature s5t out by ! ,sal-,codeia-,bell p4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #d1 #aije47 ,,sanatog5 ,cottage ,*eese--,! ,new ,elixir ( ,life,,az ,,az ,see also ,m$ical ,j\rnals & ,sanatog51 p4 #dca4 ,! psy*ology ( adv]tis+ is n[h]e bett] exemplifi$ ?an 9 ! 8pat5t m$ic9e0 & propriet>y fields4 ,! reason is evid5t4 ,kn[+ t ! g5]al t5d5cy ( ! human organism is t[>d heal? r ?an t[>d disease & t ! 8heal+ p[] ( nature0--vis m$icatrix natur--w acc\nt = a l>ge proportion ( recov]ies f sickness1 x is n to be wond]$ at t ?\s&s ( prep>ations sold = m$ic9al purposes receive cr$it t is entirely undes]v$4 ,! aw>d+ ( su* undes]v$ cr$it is l>gely due to ! univ]sal t5d5cy ( ^? :o are n tra9$ 9 sci5ce to apply ! po/ hoc1 ergo propt] hoc argum5t 9 all matt]s relat+ to heal? & disease4 ,john ,smi? suff]s f a pass+ indisposition4 ,:5 he recov]s he cr$its 8 recov]y to :atev] he may h done j prec$+ t recov]y4 ,if he has receiv$ m$ical att5tion1 ! physician gets ! cr$it2 if he has tak5 8abs5t treatm5t10 ,*ri/ian ,sci5ce is responsible2 if he has tak5 sug> pills1 8,pr(40 ,munyon gets ! praise--:ile1 z a matt] ( fact1 if he _h tak5 none ( ^! he w\ld h recov]$ s9ce he 0 only tempor>ily indispos$4 ,nor are laym5 ! only ones t fall into su* errors4 ,_m physicians :o prescribe new1 widely-adv]tis$ prep>ations are likely to give ^? products cr$it = :atev] favorable *ange may take place 9 _! pati5ts' condition4 ,?is fail+ is n a mod]n "o4 ,9 #ahdb ,dr4 ,b5jam9 ,brodie wrote3 8,we h no d\bt t _m well-in/ruct$ m$ical practition]s h n suffici5tly consid]$ :at c\rse a giv5 disease w\ld take if x 7 left to itself2 & z to o!rs1 x is n possible t !y %\ld h any real k on ! subject4 ,) ! majority ( p]sons a recov]y w g5]ally pass = a cure40 ,illu/ration3 ,greatly r$uc$ photographic reproduction ( a full-page ,sanatog5 adv]tisem5t appe>+ 9 ! ,london ,graphic4 ,! ,graphic 0 "o ( ! ,london magaz9es t refus$ to accept an adv]tisem5t ( ! book issu$ by ! ,briti% ,m$ical ,association1 expos+ 8pat5t-m$ic9e0 frauds4 ,,! ,,p[] ,,( ,,adv]tis+ ,:ile e physician is p]fectly famili> ) ! facts j /at$1 x seems wor? :ile to give !m z a probable explanation ( :at is to foll[4 ,)9 ! la/ few ye>s ! m$ical pr(ession & ! public ( ?is c\ntry h be5 ask$ to believe t a comb9ation ( cottage *eese--or its equival5t--) a small am\nt ( glyc]ophosphates is capable1 :5 sold "u a propriet>y "n & ) ! "r k9d ( adv]tis+1 ( produc+ physiologic effects t are little %ort ( m>vel\s4 ,! "n ( ?is elixir ( life is ,sanatog51 & x is d\btful if ! hi/ory ( mod]n adv]tis+ furni%es any m notable example ( ! comm]cial pot5tialities ( publicity ?an t exhibit$ 9 ! exploitation ( ?is product4 ,! ,sanatog5 adv]tis+ campaign is probably ! mo/ skilful piece ( "w ( its k9d ev] done4 ,on bo? sides ( ! ,atlantic1 e ef=t has be5 made to end[ ! adv]tisem5ts ) a dignity :i*1 to ^? :o "k ! v ord9>y nature ( ! product adv]tis$1 is grotesquely out ( keep+4 ,only ! highe/-class magaz9es & newspap]s h be5 patroniz$2 ! 8copy0 has be5 s writt5 z to appeal n to ! ignorant b to ! intellig5t4 ,te/imonials f m5 ^: names are well kn[n1 ev5 ?\gh by tra9+ & education !y are incompet5t to pass judgm5t on a product ( ?is k9d1 & fulsomely laudatory lett]s f m5 ^: education & tra9+ %\ld h taught !m bett]--bo? h be5 us$ ) all ! skill ( ! tra9$ publicity man4 ,9 %ort1 ,sanatog5 /&s z a monum5t to ! p[] ( pr9t]s' ink4 ,! claims = ?is product h already be5 ref]r$ to 9 ,! ,j\rnal1 b x w d no h>m to br+ !m aga9 be=e our read]s4 ,"h are "s tak5 f adv]tisem5ts3 8,! ,re-,creator ( ,lo/ ,heal?40 8,sanatog5 is 444 a rebuild+ food40 8444 revitalizes ! ov]work$ n]v\s sy/em40 8,specific n]ve tonic action40 8,mo/ reliable & sci5tific ( all nutri5ts40 8444 9 c]ta9 diseases x ex]ts a specific action :i* r5d]s x a valuable adjunct to o!r curative measures40 8,x /imulates metabolic activity ( tissue cells & secures m complete oxidation ( en]gy-yield+ elem5ts40 8,sanatog5 n\ri%es ! sy/em 9 a p]si/5t1 gradual1 cumulative way1 s t its be/ effects unfold !mselves 9 a sy/ematic1 sub/antial progression to heal? & /r5g?4 ,x foll[s t a regul> & prolong$ adm9i/ration ( ,sanatog5 is necess>y = ! atta9m5t ( la/+ results40 8,sanatog5 is a sci5tific comp\nd1 e p>ticle ( :i* repres5ts ! f9e/ conc5trat$1 tissue-con/ruct+ nutrim5t1 end[$ ) unique revitaliz+ & rejuv5at+ p[]s40 8,sanatog5 conta9s ov] #gjj p] c5t4 m tissue-build+1 life su/a9+ n\ri%m5t ?an :eat fl\r40 ,truly a wond]ful prep>ation--if ^! /atem5ts are true6 ,b !y are false--mo/ ( !m at lea/4 ,& 9 t _m :o c ill af=d x may be l$ to pay a ru9\sly high price = a v ord9>y food1 ! /atem5ts are vici\sly & cruelly false4 ,9 view ( ! prop]ties ) :i* ,sanatog5 is cr$it$1 its composition is naturally a matt] ( m ?an ord9>y int]e/4 ,:at is ?is life-giv+ product8 ,a package ( ,sanatog5 0 pur*as$ & subject$ to exam9ation & analysis 9 ! ,association's laboratory4 ,our *emi/s report3 ,,laboratory ,,report ,sanatog5 is a f9e1 ne>ly :ite p[d] hav+ a fa9t yell[i% t+e4 ,a circul> :i* is enclos$ 9 ! package /ates3 8,sanatog5 is a def9ite organic comb9ation ( #ie p] c5t4 ( pure1 specially prep>$ case9 & #e p] c5t4 ( sodium glyc]ophosphate14440 ,qualitative te/s indicat$ ! pres5ce 9 ,sanatog5 ( case91 sodium1 a phosphor\s comp\nd & glyc]9 or a glyc]9 comp\nd4 ,/>* & sug>s 7 abs5t4 ,quantitative analysis %[$ t ! composition ( ! specim5 0 ess5tially z foll[s3 ,wat] 7loss at #acj ,c47 #h4fj ,a% #f4bc ,case9 & o!r prote9s 7,n #f4ch7 #hc4aj ,case9 7,n 9 precipitat$ case9 #f4ch7 #hj4eg ,prote9s o!r ?an case9 7by diff]5ce7 #b4ec ,sodium glyc]ophosphate 7,na,c#c;,h#g,o#f,p7 7,p 9 filtrate f case9 precipitation #f4gi7 #e4ei ,insoluble matt] #j4hd ,undet]m9$ #a4hg ,:ile ^! results %[ t ! claims conc]n+ ! composition ( ,sanatog5 are n entirely correct1 !y indicate t ! ess5tial elem5t 9 ,sanatog5 is case94 ,! slight v>iation betwe5 ! composition claim$ = ,sanatog5 & ! composition z det]m9$ by *emical analysis is ( m9or importance4 ,:e!r !re is #hc p] c5t4 ( case9 z f\nd by ! ,association's *emi/s or #ie p] c5t4 z ass]t$ by ! manufactur]s matt]s little4 ,! important fact is t case9 makes up ab\t n9e-t5?s ( ! prep>ation &1 z mu/ be p]fectly evid5t1 ,sanatog5 d]ives :atev] food value x may h f t case94 ,case9 is kn[n 9 its commone/ =m z ! curd 9 milk1 or z 8cottage *eese40 ,aft] ! cream has be5 sep>at$1 ! milk :i* rema9s conta9s ne>ly all ! case9 & milk sug> orig9ally pres5t b practically none ( ! fat4 ,,:y ,,n ,,cottage ,,*eese8 ,:5ce comes ! /imulation ( metabolic activity1 ! wond]ful n\ri%m5t ( ! sy/em1 ! m>vel\s revitaliz+ & rejuv5at+ p[] claim$ = ,sanatog58 ,n f ! sodium glyc]ophosphate1 = ! cons5sus ( op9ion among lead+ physiologi/s indicates t phosphorus 9 ! =m ( glyc]ophosphates has little influ5ce on metabolism4 ,n f ! glyc]91 surely1 = ev5 grant+ t glyc]9 has food value ! am\nt pres5t is s small z to be negligible4 ,! real s\rce ( en]gy 9 ,sanatog51 !n1 lies 9 ! case9 :i* comprises ab\t n9e-t5?s ( its +r$i5ts4 ,co/ ( ,calories4 ,k9d ( ,food ,mat]ial ,price p]#a1jjj ,calories,en]gy = ,p\nd ,en]gy ,"o ,doll> ---------------------------------------- ------------------ ,sanatog5 #d4ed #c4ja #ccb ,cel]y 4#je 4#gg #a1cjj ,eggs 7#j4cf p] doz47 4#bd 4#af #f1cjj ,milk 7#j4jg p] qt47 4#jce 4#aa #h1hej ,pork1 lo9 roa/ 4#ab 4#aj #aj1cej ,butt] 4#cj 4#ji #aa1bej ,mack]el1 salt dress$ 4#aj 4#jh #aa1hej ,beef1 /ew meat 4#je 4#jg #ae1cjj ,:eat bread 4#jf 4#je #bj1jjj ,rice 4#jh 4#je #bj1bej ,sug> 4#jf 4#jc #bi1bjj ,pork1 fat salt 4#ab 4#jc #bi1ejj ,potatoes 4#ja 4#jc #bi1ejj ,beans1 :ite 4#je 4#jc #cj1djj ,oatmeal 4#jd 4#jb #de1jjj ,cornmeal 4#jbe 4#jb #fe1djj ,:eat fl\r 4#jbe 4#jb #fe1djj ---------------------------------------- ------------------ ,( c\rse ,sanatog51 be+ compos$ l>gely ( case91 has "s food value4 ,:at t food value is may be se5 by ! accompany+ table :i* comp>es ! yield ( en]gy = ,sanatog5 ) t ( a numb] ( /aple food products1 ! figures = ! latt] hav+ be5 adapt$ f ,pr(essor ,atwat]'s calculations4 ,?is table %[s t1 f ! /&po9t ( economy 9 ! pur*ase ( en]gy1 no o!r food 9 ! li/ is s poor z ,sanatog54 ,:ile ! manufactur]s claim t 8,sanatog5 conta9s ov] #gjj p] c5t4 m tissue-build+1 life-su/a9+ n\ri%m5t ?an :eat fl\r10 ! table %[s t "o doll>'s wor? ( :eat fl\r conta9s z mu* en]gy z "o hundr$ & n9ety-sev5 doll>s' wor? ( ,sanatog56 ,,an ,,inquiry ,l all 8pat5t m$ic9es10 ,sanatog5 is exploit$ by ! te/imonial r\te4 ,actors1 au?ors1 politicians & n a few physicians--! latt]1 to ! cr$it ( ! ,am]ican pr(ession1 be x said1 be+ *iefly ,europeans--h te/ifi$ to ! wond]ful prop]ties ( ?is product4 ,believ+ t x w\ld be ( int]e/ to le>n :at sci5tific m5 ?\ght ( ,sanatog5 a lett] ( inquiry 0 writt5 to sev]al m5 ^: tra9+ p>ticul>ly fits !m to express an imp>tial op9ion on a "q ( ?is k9d4 ,! foll[+ inquiry1 express$ 9 practically ! same words1 0 prop\nd$3 ,is x possible = a product1 ev5 if x has ! composition claim$ = ,sanatog51 to h prop]ties z a food & m$ic9e :i* are claim$ = ?is prep>ation8 ,! replies to ?is inquiry are int]e/+ & in/ructive1 al?\gh !y are :at might h be5 expect$ f m5 ^: judgm5t has n be5 w>p$ by ! glitt]+ claims ( ! ,sanatog5 publicity ag5ts4 ,illu/ration3 ,"s ( ! reasons = ! sale ( ,sanatog56 ,a few specim5 adv]tisem5ts ( ,sanatog5's enorm\sly exp5sive adv]tis+ campaign4 ,,! ,,replies ,dr4 ,lewellys ,f4 ,b>k]1 pr(essor ( m$ic9e1 ,johns ,hopk9s ,univ]sity1 m$ical dep>tm5t1 says 9 "p3 8,if ,sanatog5 consi/s simply ( case9 & sodium glyc]ophosphate1 x is pretty obvi\s t all ( its good effects 7except p]haps ! psy*ic influ5ce ( tak+ an exp5sive &1 to ! layman1 my/]i\s rem$y7 c be gott5 by includ+ milk & eggs 9 ! food4444 8,! objection to ,sanatog5 lies1 x seems to me1 n 9 ! ass]tion ( its proprietors t x is a #8food & a tonic1' b 9 ! mislead+ ( ! public & physicians into ! belief t x possesses extraord9>y p[]s :i* make x wor? :ile to pay ! price *>g$ = x 9 ord] to get x4 ,v extravagant claims are be+ made = x 9 adv]tisem5ts 9 ! lay press4 ,if j z mu*1 & m1 good 9 ! =m ( #8food & tonic' c be obta9$ f a doll>'s wor? ( milk & eggs z f a doll> & n9ety c5ts' wor? ( ,sanatog51 x is surely ! duty ( ! m$ical pr(ession to in=m ! public ( t fact40 ,dr4 ,frank ,bill+s1 pr(essor ( m$ic9e & head ( ! ,dep>tm5t ( ,m$ic9e1 ,univ]sity ( ,*icago1 expresses 8 op9ion ?us3 8,( c\rse1 ! ?+ is a fraud bo? z a food & z a tonic4 ,ev5 if x met all ! requirem5ts ( ! /atem5ts made ( x by ! mak]s1 x w\ld n be any m ( a food ?an z mu* case9 tak5 9 milk & probably n z good2 or any m ?an "s o!r album9 tak5 9 "s o!r =m4 ,i d n "k j :at ph>macologi/s say ( ! glyc]ophosphate ( soda1 b s f> z my own cl9ical obs]vations g ,i nev] saw any result f its use t c\ld be call$ specific1 t is1 due to ! drug40 ,dr4 ,ri*>d ,c4 ,cabot1 assi/ant pr(essor ( cl9ical m$ic9e1 ,h>v>d ,m$ical ,s*ool1 says3 8,9 reply to y\r lett] respect+ ! prop]ties ( ,sanatog51 ,i w\ld say t 9 my op9ion x is va/ly improbable t x has ! prop]ties claim$ = x 9 ! adv]tisem5ts :i* y enclos$ to me4 ,i h no d\bt t x is a fairly good food4 ,i see no reason to believe t ! phosphorus t x conta9s has any special action40 ,otto ,fol91 pr(essor ( biological *emi/ry1 ,h>v>d ,m$ical ,s*ool1 expresses himself ?us3 8,= myself1 or = any "o :o w\ld take my advice1 ,i w\ld pref] a glass ( milk to ,sanatog5 :5 hungry & pla9 glyc]ophosphate to ,sanatog5 :5 9 ne$ ( a tonic4 8,m$icat$ fe$ us$ to be sold = horses4 ,to me ! #8food tonic' comb9ation repres5ts "o ( ! mo/ unscrupul\s fake ideas us$ by manufactur]s ( pat5t$ articles to fool ! public40 ,ludvig ,hekto51 pr(essor ( pa?ology1 ,univ]sity ( ,*icago1 says 9 "p3 8,9 my op9ion1 no att5tion :atsoev] %\ld be paid to ! claims advanc$ 9 favor ( #8,sanatog5' z food & z m$ic9e1 because ! /atem5ts made 9 ! adv]tisem5ts ( ?is product are extravagant1 mislead+ & quacki%40 ,j4 ,h4 ,long1 pr(essor ( *emi/ry & director ( *emical laboratories1 ,nor?we/]n ,univ]sity ,m$ical ,s*ool1 expresses ! foll[+ op9ion3 8,) e read+ ( ! adv]tis+ lit]ature ( ! ,sanatog5 ,company ,i am m & m impress$ by ! gross exagg]ation ( ! claims made = ?is mixture ( case9 & sodium glyc]ophosphate4 ,c['s milk conta9s #c-a_/b to #d p] c5t4 ( case91 associat$ ) soluble phosphates4 ,x is absurd to ?9k t ?is case9 aft] precipitation f ! milk has a great] nutritive value ?an x has 9 its native condition4 ,case91 at be/1 is probably less valuable z a food ?an are c]ta9 o!r prote9s1 because ( its lack ( "s ( ! am9o gr\ps ess5tial 9 tissue build+1 & ! addition ( a glyc]ophosphate _c supply ?is defici5cy4 8,?is is n ! fir/ attempt to exploit case9 prep>ations4 ,! e>li] ef=ts fail$ 9 practice because !y 7 bas$ on a wrong conception conc]n+ ! physiologic value & importance ( ?is prote94 ,! assumption t 9 ! case ( ,sanatog5 a #8def9ite organic comb9ation' ) ! glyc]ophosphate is =m$ _c be tak5 s]i\sly by *emi/s4 ,we h witness$ _m su* ef=ts to palm (f mixtures z def9ite organic comp\nds1 & 9 ?is way to claim = !m a value 9 excess ( t :i* !y actually possess40 ,illu/ration3 ,,:at ,,"o ,,doll> ,,w ,,buy ,,9 ,,food ,,en]gy6 ,a ,,comp>ison ,,( ,,! ,,caloric ,,values ,,( ,,sanatog51 ,,c[',s ,,milk1 ,,sug> ,,& ,,:eat ,,fl\r4 ,,bas$ ,,on ,,! ,,table ,,accompany+ ,,?is ,,article4 ,graham ,lusk1 pr(essor ( physiology1 ,cornell ,univ]sity ,m$ical ,college1 aft] call+ att5tion to ! falsity ( ! claim t ,sanatog5 is 8a life-su/a9+ ag5t 9 disease10 says3 8,if "o consid]s ! case9 cont5t alone1 ! dose ( ,sanatog5 recomm5d$ 9 ! circul> w\ld furni%1 at be/1 ab\t :at is conta9$ 9 a p9t ( milk1 or "o-f\r? ( ! total ( ! prote9 necessities ( ! body--us+ a l[ prote9 requirem5t4 ,t sodium glyc]ophosphate has any di/9ctly b5eficial physiologic action has nev]1 to my k1 be5 %[n4 8,x is a great pity t ! public does n realize ! spl5did & economical value ( milk1 bread & ! ord9>y vegetables1 c]eals & meats1 z true #8tonic food /uffs1' 9 contradi/9ction to prep>$ no/rums ^: sale dep5ds on a psy*ic /imulus appli$ to a susceptible populace40 ,h4 ,gideon ,wells1 associate pr(essor ( pa?ology1 ,univ]sity ( ,*icago1 says3 8,!re is no?+ 9 my k ( physiologic *emi/ry :i* w\ld lead me to believe t a mixture ( *emically isolat$ case9 & sodium glyc]ophosphate w\ld possess any effect m favorable ?an t ( a correspond+ am\nt ( milk4 ,i c easily believe t x w\ld be less valuable ?an milk4 ,! successful practice ( _m comm]cial h\ses1 ( isolat+ "o ( ! con/itu5ts ( our food1 & ascrib+ to x m>vel\s nutritive or !rapeutic prop]ties1 is "o ( ! mo/ tell+ bits ( evid5ce ( ! inadequacy ( ! education ( ! m$ical pr(ession 9 physiology & physiologic *emi/ry t c be conceiv$40 ,! cons5sus ( op9ion ?us express$ is only :at might h be5 expect$ f m5 :o c\ld discuss ! problem 9 a purely judicial _s & ) a fre$om f t bias :i* seems to be insep>able f ! consid]ation ( ! simple/ ( mixtures t h be5 glorifi$ by a propriet>y "n4 ,,! ,,tyranny ,,( ,,words ,h]r ,teufelsdrckh 0 "r :5 he panegyriz$ clo!s4 ,& ! wor%ip ( clo!s is c>ri$ to ! extreme n[h]e s mu* z 9 ! case ( ^w-clo!s4 ,! mo/ plebeian ?+s :5 b$eck$ 9 suffici5tly impos+ ^w-f9]y are end[$ ) ! attributes ( royalty be=e :i* ! av]age intellect b[s d[n4 ,nei!r cottage-*eese nor glyc]ophosphates1 :5 expos$ nak$ to ! _w1 comm&s any ov]we5+ respect2 comb9$ & dress$ 9 ! magic ^w 8,sanatog510 !y receive ! homage ( ^? ^: judgm5t is bl9d$ by ! glitt]+ trapp+s ( ^w-f9]y4 ,"s day1 possibly1 !re w be a democracy ( intellect :i* w refuse to pro/rate itself be=e m]e ^w-raim5t & w insi/ on apprais+ ?+s at _! nak$ wor?4 ,:5 t day comes1 propriet>y humbugs l ,sanatog5 w h become z ext9ct z ! dodo & ! great auk4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,april #bj1 #aiab47 ,! ,bau] ,*emical ,company's 8,reply0 ,to ! ,editor3--,our att5tion has be5 call$ to a mo/ unfair & unw>rant$ attack on ,sanatog5 :i* appe>s 9 y\r e/eem$ publication ,april #bj1 p4 #abaf4 ,! article is su* a p]v]sion ( ! actual facts1 & s completely--if n int5tionally--mislead+ t we reque/1 z a matt] ( common ju/ice1 t y give ?is reply equal publicity to y\r attack4 ,! admiration & respect we h felt = y\r j\rnal & our appreciation ( ! place x holds 9 ! field ( m$ical j\rnalism1 made y\r attack on a product l ,sanatog51 repres5t+ s def9itely ! mo/ pa9/ak+ & sci5tific rese>*1 ! la/ ?+ expect$4 ,inde$1 x seems inconceivable t a j\rnal app>5tly s alive to its responsibilities c\ld publi% broadca/ an article s calculat$ to d h>m1 )\t fir/ giv+ ^? ^: int]e/s are mo/ at /ake an opportunity to sub/antiate _! claims4 ,!re nev] has be5 a "t t we h n be5 ready to meet any reque/ f ,! ,j\rnal1 or ! respect$ g5tlem5 compos+ ! ,c\ncil on ,ph>macy & ,*emi/ry1 = all in=mation & data conc]n+ ,sanatog54 ,_h we _h ! slighte/ inkl+ t our product--or ! claims made = x--7 op5 to "q or criticism1 we w\ld gladly h submitt$ all ( ! evid5ce1 cl9ical1 exp]im5tal1 & !oretical1 on :i* e /atem5t1 h[ev] simple1 has be5 bas$4 ,to make a response is difficult1 because y\r article is n writt5 9 a fair1 unprejudic$ _s4 ,9 fact1 al?\gh "o w\ld expect a sob]1 s]i\s consid]ation ( a matt] s fraught ) importance 7if y\r cont5tion is "r7 y\r :ole attitude is "o ( ridicule & jocul>ity4 ,is x "r to pres5t sci5tific mat]ial 9 su* a way & %[ s little respect = ^? :o h (f]$ y no affront or done y no injury8 ,a little inve/igation w\ld h %[n y t ! /atem5ts we h made ab\t ,sanatog5 are bas$ on ! exp]i5ces & op9ions ( su* m5 z von ,noord51 ,c4 ,a4 ,ewald1 ,duhrss51 ,eul5burg1 ,neiss]1 ,b9swang]1 von ,leyd51 ,krafft-,eb+1 ,tillmanns1 ,tunnicliffe1 & ?\s&s ( o!r e>ne/1 reputable physicians4 ,any "o might diff] ) _! conclusions1 b is x c\rte\s or dec5t to hold !m up to ridicule & contumely8 ,c a discussion ?us conduct$ hope to solve a sci5tific problem or accompli% any real good8 ,x w\ld h>dly seem s1 & ) all due respect we _c help b feel t ! situation has its analogy 9 ! legal doctr9e1 8:5 y h no evid5ce1 ridicule & abuse y\r oppon5t & 8 cli5t40 ,sanatog5 is a def9ite organic comb9ation ( 79 r\nd numb]s7 #ie p] c5t4 case9 & #e p] c5t4 glyc]ophosphate ( sodium4 ,! analysis z publi%$ 9 ,! ,j\rnal fails to %[ t ?is /atem5t is untrue4 ,! slight deviation z to ! am\nt ( case9 pres5t is expla9$ by ! fact t ,! ,j\rnal's figures include ! moi/ure1 :ile ours are on ! dry sub/ance4 ,inasmu* z ne>ly all ! moi/ure is absorb$ aft] ! product leaves ! laboratories & is !re=e add$ weight1 ! figures %\ld be on ! dry sub/ance4 ,x is h9t$ 9 ! article t ,sanatog5 is a m]e mixture ( +r$i5ts1 9 fact "o ( ! g5tlem5 y quote op5ly intimates s4 ,to ?is we say mo/ emphatically t anyone ass]t+ ,sanatog5 to be a m]e me*anical mixture ( +r$i5ts & n a def9ite *emical comp\nd ei!r wilfully mis/ates ! facts or does n "k4 ,sanatog5 repres5ts a new idea or discov]y 9 ! doma9 ( invalid dietetics & z su* its process ( manufacture z well z ! product are protect$ by ,u4 ,s4 ,lett]s ,pat5t4 ,assur$ly x is ! def9ite *emical comb9ation f\nd 9 ,sanatog5 on :i* ! special value ( ?is product z a m$ic9al food & tonic dep5ds4 ,a m]e mixture ( +r$i5ts w\ld repres5t only ! sum-total ( _! individual virtues1 b a def9ite comb9ation ( su* +r$i5ts means ! =mation ( a new comp\nd ) prop]ties ( its own :i* f> transc5d ^? ( any simple mixture ( ! orig9al +r$i5ts4 ,to comp>e ,sanatog5 to cottage *eese is ! height ( absurdity--z x 0 probably int5d$ to be4 ,! case9 ( ,sanatog5 is p]haps ! mo/ c>efully purifi$ milk prote9 available1 & ?is fact is ( ess5tial importance :5 consid]+ ! value ( ,sanatog5 z a m$ic9al food4 ,to comp>e ! case9 ( ,sanatog5 ) crude comm]cial case9 or ) cottage *eese is z ridicul\s z to comp>e a crude drug ) ! ref9$ elem5t4 ,! same applies to ! matt] ( co/4 ,we sugge/ t an attempt be made to prep>e purifi$ case9 accord+ to ,hamm>/5's me?od1 if "o wi%es to det]m9e :at labor & exp5se is involv$ 9 ! op]ation4 ,possibly x w be f\nd *eap] to buy ,hamm>/5's case9 9 ! op5 m>ket :]e ! price is #c4ej p] p\nd :olesale6 ,& x is n a propriet>y product1 ei!r4 ,fur!r1 to comp>e ! economic value ( ,sanatog5 on ! basis ( calories is z unsci5tific z x is delib]ately mislead+4 ,if ! caloric /&>d only c\nt$1 a p\nd ( oleom>g>9e w\ld be z valuable z fifty eggs1 a p\nd ( laundry soap z valuable z a p\nd ( *oice beef4 ,sanatog5 is n int5d$ or recomm5d$ to replace ord9>y food/uffs4 ,x is n recomm5d$ z a caloric or heat produc]1 b z a food-tonic supply+ ! ess5tial elem5ts ( tissue con/ruction & cell-repair 9 easily & p]fectly assimilable =m4 ,dige/ibility1 ease & complet5ess ( assimilation c\nt a great deal1 & are ! sole det]m9+ factors 9 cases ( illness4 ,aga91 />* & fat are n ess5tial sub/ances to life4 ,)\t prote9 we _c live4 ,exclude ev]y?+ else f a pati5t's diet>y1 & he w live4 ,exclude prote9 & x is only a "q ( "t be=e he dies4 ,x is evid5t1 !re=e1 t to measure ! value ( a giv5 food 9 calories only is mislead+ & dang]\s1 & an editorial 9 y\r valuable publication ( ,novemb] #d la/ di/9ctly po9ts ?is out4 ,illu/ration3 ,specim5s ( ,sanatog5 adv]tis+--7#aiac74 ,accord+ to ! mo/ c>eful & ext5sive exp]im5ts1 cov]+ a l>ge numb] ( sci5tifically /udi$ cases1 ,sanatog5 is n approa*$ 9 ! matt] ( rapidity ( dige/ion & absorption by any o!r kn[n food/uff4 ,t su* a product does ex]t a def9ite /imulat+ or activat+ effect on ! dige/ive & assimilative functions1 ?us promot+ ! dige/ion & appropriation ( nutritive mat]ial has be5 demon/rat$ ov] & ov] aga94 ,t ! organic phosphorus ( ,sanatog5 is almo/ completely reta9$ & assimilat$ has be5 prov$ beyond d\bt by c>efully conduct$ metabolism exp]im5ts4 ,t f ?is1 & f ! /imulat+ action on phosphorus & nitrog5 metabolism1 a favorable effect on ! n]v\s sy/em c\ld result1 is conceivable4 ,t su* an effect does actually take place has be5 demon/rat$ cl9ically 9 lit]ally ?\s&s ( cases4 ,z to our adv]tisem5ts & lit]ature3 ,e claim made emanates f ! freely record$ /atem5ts ( compet5t obs]v]s1 *eck$ & re*eck$ by m5 :o h be5 absolutely free f all bias or prejudice4 ,& ^! op9ions1 moreov]1 are n ! sup]ficial1 pass+ views ( a few physicians4 ,in/ead our claims are bas$ on ! volunt>y1 unbias$ writt5 reports ( cl9ical exp]i5ces by ov] #ae1jjj practic+ physicians--among :om a goodly proportion are memb]s ( y\r e/eem$ ,association--& on ov] #aej publi%$ articles 9 ! lead+ m$ical j\rnals ( ! _w1 "s ( :i* y\r j\rnal has consid]$ ( suffici5t importance to pres5t to its read]s 9 ab/ract =m1 suppress+1 x is true1 all m5tion ( ,sanatog51 al?\gh !reby ! orig9al 0 sadly emasculat$1 if n actually falsifi$4 ,among ! physicians :o h c>efully te/$ ,sanatog5 & det]m9$ its dietetic & !rapeutic prop]ties are _m m5 ( truly int]national reputation1 m5 :o are z f> above suspicion z 0 ,caes>'s wife4 ,at lea/ "o ( ^! m5 0 ! honor>y gue/ ( y\r ,association a few ye>s ago4 ,x is su* m5 t y\r article holds up to contempt & di%onor :5 y all[ ! false inf]5ce to g =? t ,sanatog5 is a mixture ( case9 & glyc]ophosphates4 ,x is su* m5's c>eful rese>*es & exp]i5ce t y attempt to (fset by ! snap judgm5t ( m5 :om we claim1 )\t ! slighte/ int5t ( disp>ag+ !m1 to be 9 ! pres5t in/ance unfitt$ to give an op9ion on ,sanatog5 inasmu* z !y--) p]haps "o honorable exception--h nev] te/$ or us$ ! product4 ,_! lack ( def9ite k ( ,sanatog5 is %[n by _! p]si/5t ref]5ces to case9 & ! glyc]ophosphates1 z ?\gh ^! two +r$i5ts 7 sep>ate & n *emically comb9$4 ,to consid] ,sanatog5 a mixture is to lose ! vital detail ( its specific value4 ,n[ aft] all1 is ?is a fair1 judicial _s1 is ?is true sci5tific enquiry8 ,are we to accept (fh& judgm5ts 9 pref]5ce to ! op9ions ( ^? :o speak f ye>s ( obs]vation ( ! effects ( ,sanatog58 ,9 ! "n ( ju/ice & fair play1 is x "r = ! great ,j\rnal ( ! ,a4 ,m4 ,a4 to ignore & suppress ! accumulat$ evid5ce 9 favor ( ,sanatog5 & cite in/ead ! cursory op9ions ( m5 :o h nev] se5 ,sanatog51 te/$ or obs]v$ its effect1 :o by ! v nature ( y\r enquiry mu/ h be5 influ5c$ subconsci\sly 9 favor ( y\r side ( ! matt]4 ,illu/ration3 ,! above is a r$uc$ reproduction ( a full-page adv]tisem5t 9 a magaz9e devot$ to pseudo-sci5tific fads4 ,! adv]tis+ pages ( ?is magaz9e reek ) frauds4 ,dur+ ! twelve ye>s ,sanatog5 has be5 us$1 prescrib$ & recomm5d$ by ?\s&s ( compet5t physicians1 x has be5 free f all secrecy4 ,! tru? has be5 told at all times4 ,f ! fir/ we h coop]at$ ) ! pr(ession4 ,nev] h we fail$ to safegu>d ! doctor's int]e/s4 ,nev] h we sugge/$ by ^w or inf]5ce t any p]son %\ld employ ,sanatog5 to ! exclusion ( m$ical treatm5t4 ,n a day passes b we ref] p :o inquire ab\t ?is or t bodily ill1 to _! physicians = advice4 ,we regret ! l5g? ( ?is lett] b feel t ! sci5tific "* ( ,sanatog51 its well-def9$ *emi/ry & ! respect we owe to ! m5 :o h n hesitat$ to give _! hone/ op9ions conc]n+ its food & tonic effects1 make x imp]ative t we refute at once errors & mislead+ /atem5ts1 & correct to ! be/ ( our ability ! wrong impression y h all[$ to g =?4 ,! cl9ical reports & /atem5ts & ! sci5tific evid5ce on :i* we h bas$ our claims are con/antly available & may be exam9$ by any responsible p]son = v]ification or any o!r legitimate purpose4 ,we h tri$ to make ?is article temp]ate1 fair & free f ill temp] & ill feel+4 ,we only ask = ju/ice & feel t y w be will+--possibly anxi\s--to correct1 s f> z y c1 ! great wrong y h done u4 ,! ,bau] ,*emical ,co4 ,by ,f4 ,w4 ,hehmey]1 ,resid5t ,manag]4 ,comm5t3 ,we devote consid]able space to ! above free adv]tisem5t ( ,sanatog51 z ,! ,j\rnal does n want to be accus$ ( be+ unfair1 ev5 to pat5t m$ic9e v5d]s4 ,z our read]s w recognize1 ! above is simply a reit]ation ( ! /atem5ts t h be5 publi%$ 9 ! adv]tisem5ts ( ,sanatog54 ,! song t runs ?r\gh all ! adv]tis+ matt] is t ,sanatog5 is a *emical comp\nd1 & s9ce x is a *emical comp\nd x !re=e possesses prop]ties n to be f\nd 9 ! ord9>y mixture4 ,x is ! old1 old /ory2 ! 8syn!tic0 argum5t is z ho>y z ! no/rum bus9ess itself b =tunately ! m$ical pr(ession is no long] easily fool$ by x4 ,z a matt] ( fact1 ev5 assum+ = ! sake ( argum5t t ! case9 & glyc]ophosphate 9 ,sanatog5 are 9 *emical comb9ation1 x w\ld be a union ( ! loose/ k9d1 :i* on ent]+ ! dige/ive tract mu/ be brok5 up into its m /able compon5ts1 case9 & glyc]ophosphate4 ,to claim t ,sanatog5 possesses any prop]ties n possess$ by its ess5tial con/itu5ts is a silly piece ( pseudo-sci5tific claptrap4 ,( ! te/imonials on ,sanatog5 we %all at ?is "t h no?+ to say2 ,! ,j\rnal has 9 ! pa/ repeat$ly %[n ! wor?lessness ( ?is k9d ( evid5ce4 ,we h no?+ to retract1 r we w\ld emphasize &1 _h we space1 enl>ge on :at we h already publi%$1 = we believe t a l>ge & un=tunate portion ( ! public1 t c ill af=d x1 is pay+ a ru9\sly high price = a sub/ance hav+ a v m$iocre food value4 ,t indig5t consumptives1 = in/ance1 %\ld be l$ by glitt]+ falsehoods to squ&] on ,sanatog5 money t %\ld g = 8food tonics0 ( inf9itely great] value1 su* z eggs1 milk1 vegetables & meats1 is n only economic wa/e b inhuman cruelty4--,ed4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,may #ah1 #aiab47 ,! ,sanatog5 8,gr& ,prix0 ,a numb] ( lett]s h be5 receiv$ rec5tly express+ surprise t ,sanatog5 _h be5 grant$ a 8gr& prix0 at ! ,exhibition ( ,m$ical & ,surgical ,mat]ial held 9 ,london at ! same "t t ! ,sev5te5? ,int]national ,congress ( ,m$ic9e 0 9 session4 ,! correspond5ts h ask$ :at su* an 8honor0 meant4 ,! company :i* exploits ,sanatog5 9 ! ,unit$ ,/ates has n be5 sl[ to apprise ! ,am]ican public ( ! aw>d4 ,x has gone fur!r & has writt5 ! adv]tis+ manag]s ( magaz9es--includ+ ^? t _h refus$ ,sanatog5 adv]tisem5ts--direct+ _! att5tion to ! fact t ,sanatog5 0 aw>d$ a 8gr& prize0 & op9+ t 8?is unusual di/9ction0 %\ld make pla9 8! desirability ( ! pres5ce ( ,sanatog5 9 ! adv]tis+ columns ( y\r e/eem$ publication40 ,^? famili> ) ! me?ods ( aw>d+ prizes1 m$als & c]tificates to comm]cial firms & _! products at expositions & exhibitions atta* little weight to ! 8honors0 ?us conf]r$4 ,x is a fact t mo/ pur*as]s ( l>ge--& exp5sive--exhibit space at su* exhibitions receive "s k9d ( aw>d :i*1 x is tacitly und]/ood1 w be a useful adv]tis+ asset4 ,e "o c call to m9d _m food products ( m$iocre quality t h flaunt$ on _! labels ! gold m$als receiv$ at v>i\s expositions4 ,nev]!less1 x seem$ wor? :ile to f9d out j :at ! connection 0 betwe5 ! comm]cial exhibition at :i* ,sanatog5 receiv$ ! gr& prize & ! ,sev5te5? ,int]national ,congress ( ,m$ic9e4 ,! foll[+ facts 7 develop$3 ,! comm]cial exhibition 0 entirely di/9ct & sep>ate f ! sci5tific exhibit ( ! ,congress4 ,x 0 manag$ & conduct$ by a ,briti% drug j\rnal :i* _h be5 giv+ annual 8exhibitions0 ( its own = "s ye>s pa/1 & ?is took ! place ( its regul> exhibition4 ,imm$iately aft] ! aw>ds 7 made public ! adv]tis+ pages ( ?is drug j\rnal 7 fill$ ) full-page adv]tisem5ts ( ! v>i\s products t receiv$ prizes4 ,x may int]e/ our read]s to "k t :ile ! cottage-*eese-glyc]ophosphate product ,sanatog5 receiv$ a 8gr& prize0 two o!r propriet>y cottage-*eese-glyc]ophosphate products receiv$ 8gold m$als0 at ! same "t4 ,9 ! ph>maceutical dep>tm5t ( ! exhibit a widely--& fraudul5tly--adv]tis$ 8pat5t m$ic9e0 receiv$ a silv] m$al6 ,f ! facts giv5 x %\ld n be difficult to appraise at its "r value ! 8honor0 conf]r$ on ,sanatog54 ,! fact t ! exploit]s ( ?is prep>ation are try+ to make capital out ( ?is 8aw>d0 is significant4 ,illu/ration3 ,nor is ev5 ! ,asiatic neglect$ 9 ! ,sanatog5 adv]tis+ campaign4 ,"h is reproduc$ an adv]tisem5t appe>+ 9 an ,asian sport+ newspap] publi%$ 9 ,india4 ,! orig9al adv]tisem5t 0 #aj in*es by #ae in*es4 ,among ! memb]s ( ! ,aw>d ,jury ^: names 7 giv5 by ?is drug j\rnal 7 ?ree m5 ( prom95ce 9 ,great ,brita91 to :om we h writt54 ,a reply has be5 receiv$ f "o1 ,dr4 ,/eph5 ,paget1 :o says3 8,i 0 n on ! jury1 nor d ,i "k any?+ ab\t ! matt]4444 ,i _h no?+ :atev] to d ) ! aw>d+ ( prizes40--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,oct4 #aa1 #aiac47 ,a ,re/atem5t ( ! ,case ,! case aga9/ ,sanatog5 has be5 pretty pla9ly giv5 at diff]5t times 9 ,! ,j\rnal1 b ! sale ( ! /uff goes on--?anks to ! p[] ( adv]tis+4 ,"o criticism t has be5 made ( ?is pat5t m$ic9e is ! exorbitant price *>g$ = x4 ,?is objection1 al?\gh b an incid5tal "o1 is ! "o t app>5tly appeals to ! layman m /rongly ?an ! mu* m s]i\s criticism1 fraud 9 exploitation4 ,y arre/ ! att5tion ( ! av]age man :5 y appeal to 8 purse2 he res5ts pay+ an exorbitant price = any?+4 ,?is probably acc\nts = ! fact t ?is p>ticul> criticism has app>5tly hurt ! sale ( ,sanatog5 to a great] degree ?an ! m s]i\s objections made to ! prep>ation4 ,?is also acc\nts1 d\btless1 = ! fact t ! attempts to answ] ,! ,j\rnal criticisms1 by ^? :o are sell+ ,sanatog51 h be5 l>gely devot$ to ! "o po9t--its outrage\sly high price4 ,! fundam5tal objection to ,sanatog5 is n its high price1 b ! attempt to ascribe to a mixture ( case9 & glyc]ophosphates p[]s n possess$ by ^! +r$i5ts--9 o!r words1 ! mislead+ & fraudul5t claims made = x4 ,ev5 if x 7 sold at co/ price1 ! /uff1 z at pres5t adv]tis$1 w\ld /ill be a fraud4 ,! nub ( ! :ole matt] is3 ,! claims made = ,sanatog5 are unw>rant$1 mislead+ & fraudul5t4 ,,"s ,,fraudul5t ,,claims ,! con/itu5ts ( ,sanatog5 are case9 & sodium glyc]ophosphate4 ,^! two v ord9>y sub/ances possess1 s ! ,sanatog5 p w\ld h u believe1 peculi> prop]ties :5 !y are br\ght toge!r 9 *emical comb9ation4 ,sanatog51 !y claim1 is a *emical comb9ation ( ^! con/itu5ts4 ,! claim may be a good 8sell+-po9t10 b x _c be1 & is n1 s]i\sly tak5 by *emi/s4 ,b ev5 suppos+1 = ! sake ( argum5t1 t sodium glyc]ophosphate & case9 c\ld be comb9$1 !re is n a sc9tilla ( evid5ce to %[ t su* a comb9ation c\ld survive ! de/ructive influ5ce ( dige/ion & be absorb$4 ,:e!r ,sanatog5 is a *emical comb9ation ( case9 & sodium glyc]ophosphate or a m]e me*anical mixture ( ^! two sub/ances is really immat]ial4 ,9 ei!r case1 x w\ld be sep>at$ into its con/itu5t p>ts by ! dige/ive juices & w\ld h ! prop]ties ( sodium glyc]ophosphate & case91 & no?+ m4 ,rememb]+ ?is1 let u exam9e once m "s ( ! claims made = ?is pat5t m$ic9e3 8,sanatog5 is a n]ve & tissue food = :i* ! bra91 sp9al cord & ! n]ves h a special pr$ilection40 8444 practically id5tical ) ! ma9 +r$i5t ( n]ve & muscle cells44440 8,sanatog5 /&s pre-em95t 9 its p[] to fe$ ! n]ve c5t]s1 to promote heal?y dige/ion1 to give /r5g? & endurance to ! entire sy/em40 8444 food = tir$ n]ves44440 8444 a rational1 sci5tific n]ve-food40 ,to ! physiologi/1 ! t]m 8n]ve-food0 is an absurdity4 ,! processes ( dige/ion r$uce ! album9\s sub/ances 7prote9s1 su* z case97 ( ! food to simpl] =ms4 ,?is is true no matt] :at may be _! s\rce4 ,:e!r ! prote9s are d]iv$ f ! glut5 ( :eat1 ! case9 ( milk or ! album9 ( egg1 "o w 8fe$ ! n]ves0 j z well z ! o!r4 ,& ,sanatog5 8fe$s ! n]ves0 no m ?an1 9 fact n z mu* z1 d bread & meat & eggs4 ,( c\rse1 ! case9 9 ,sanatog5 has food-value1 b s has ord9>y case9--cottage *eese1 8pot *eese10 or ! ,g]man ,s*mi]kse1 = in/ance--& x is bo? false & fraudul5t to claim = ! case9 9 ,sanatog5 any great] nutritive value ?an t possess$ by ! case9 9 ord9>y milk4 ,to pret5d t !re are wond]ful prop]ties 9 ! prote9 ( ,sanatog5 :5 j z good prote9 c be pur*as$ 7= mu* less money7 f ! milkman1 is to p]petrate a fraud on ! pur*as]4 ,"h are "s m claims3 8444 m>vel\s revitaliz] ( n]ve heal?40 8444 ,sanatog5 has positive recon/ructive =ce 9 neura/h5ia40 8,if ,y ne$ ,new ,/r5g? & ,vitality ,y %\ld at once get acqua9t$ ) ,sanatog540 ,/rangely l ! 8lo/ manhood0 adv]tisem5ts1 ?is la/4 ,& ?is1 also3 8444 has br\ght new /r5g?1 new vitality & new reli% ( life to ?\s&s ^u ?\s&s :o suff]$ f />v$ n]ves44440 8,c\ntless p 444 h rega9$ fre% heal? & vigor ?r\gh ! vitaliz+ & invigorat+ effects ( ,sanatog540 ,( c\rse ,sanatog5 is n sold z a 8consumption cure40 ,no su* crude claims z ^! emanate f ! skill$ adv]tis+ ag5ts employ$ by ! ,sanatog5 p4 ,if !y did !y c\ld n get space 9 high-grade magaz9es6 ,z a prev5tive ( consumption1 h[ev]1 we f9d3 8,sanatog5 444 creates new tissue & n]ve capital 444 ,?is n]ve capital w 444 save ! individual f attacks ( acute disease4 ,aga9/ tub]culosis x is an excell5t inve/m5t40 ,also1 x is a pick-me-up6 ,?us3 8,sanatog5 promises to pick y up :5 run d[n--x does s40 ,mo/ p are "u ! necessity ( work+ = a liv+4 ,if we are to believe ! ,sanatog5 adv]tisem5ts1 x seems rem>kable t ! human race has manag$ to jog along = s _m c5turies )\t ?is product1 = we read3 8,x is practically indisp5sable to all :o are unable to take prolong$ re/44440 ,naturally we d n expect to f9d ! co>se1 8free-to-y-my-si/]0 type ( claims 9 ,sanatog5 adv]tisem5ts4 ,nev]!less3 8,wom5 444 f9d 9 ,sanatog5 a g5u9e su/a9+ ag5t40 ,illu/ration3 ,sanatog5 is adv]tis$ heavily 9 ! ,briti% ,isles4 ,"h are "s greatly r$uc$ adv]tisem5ts appe>+ 9 ,briti% magaz9es4 ,! ?ree l>ge/ adv]tisem5ts %[n "h measur$ 9 ! orig9al #aj in*es by #ad in*es1 ea*4 ,f9ally1 we w\ld respectfully direct ! att5tion ( ^? g5tlem5 ( ! m$ical pr(ession :o h s f> =gott5 ! dignity ( _! call+ z to give fulsome puffs = ?is case9-glyc]ophosphate product to ! foll[+ claims & ask :e!r !y really subscribe to !m3 8444 x revivifies ! n]ves1 promot+ sleep & help+ dige/ion44440 8444 x builds up ! blood1 creat+ new /r5g? & ! p[] to d & accompli%40 8444 ,sanatog5 is a natural1 heal?ful food & tonic44440 8444 a heal? & /r5g? giv+ food & tonic compos$ ( ^? v elem5ts :i* make cell & tissue gr[40 8,blood & tissues alike hung] = ,sanatog5 z _! conc5trat$ n\ri%m5t40 8,sanatog5 is ! "o food tonic t comm&s y\r absolute confid5ce40 ,h[ _m intellig5t physicians really believe t !re is ! slighte/ basis ( fact = ! claims we h quot$8 ,yet x is by means ( ^! claims t ,sanatog5 is be+ foi/$ on a public t looks to ! m$ical pr(ession = enlight5m5t & tru?4 ,& e quotation 9 ?is article is tak5 f adv]tis+ matt] issu$ dur+ ! curr5t ye>1 #aiac6 ,9 clos+1 let u reit]ate3 ,! objections to ,sanatog5 are prim>ily ! objection to any fraud4 ,x is be+ sold "u unsci5tific1 mislead+ & fraudul5t claims2 moreov]1 al?\gh ?is is ( less importance1 ! pur*as] pays an extraord9>y price = a mo/ ord9>y product4 ,we believe ! "t w come :5 ev5 ! artificial /imulus ( va/ adv]tis+ appropriations w be insuffici5t to ov]come ! in]tia inh]5t 9 a product ( small m]it4 ,:5 t "t comes1 ,sanatog5 w die a natural dea?4 ,9 ! meantime1 its exploit]s are reap+ a gold5 h>ve/1 ( :i* no small "p is be+ divid$ among publi%]s1 m$ical & o!rwise4 ,& ! cr$ul\s among ! sick & suff]+ pay ! bills6--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,dec4 #f1 #aiac47 ,,sanatog53 ,a ,,sci5tific ,,inve/igation ,,( ,,its ,,alleg$ ,,action ,,on ,,! ,,recup]at+ ,,p[]s ,,( ,,! ,,blood ,sanatog51 ! new elixir ( life comp\nd$ ( case9 & glyc]ophosphates1 has be5 notic$ 9 ,! ,j\rnal f "t to "t4 ,x w be rememb]$ t1 :ile x has be5 claim$ t 8,sanatog5 conta9s ov] #gjj p] c5t4 m tissue-build+1 life su/a9+ n\ri%m5t ?an :eat fl\r10 ! facts are t "o doll>'s wor? ( :eat fl\r conta9s z mu* en]gy z "o hundr$ & n9ety-sev5 doll>s' wor? ( ,sanatog56 ,to ?is ! manufactur]s rejo91 9 effect1 t ! case9 & glyc]ophosphates 9 ,sanatog51 be+ 9 *emical comb9ation1 possess a my/ical & esot]ic virtue n measurable 9 t]ms ( ! food-value ( ! sev]al +r$i5ts4 ,! fact is1 ( c\rse1 t ev5 assum+1 = ! sake ( argum5t1 t ! +r$i5ts ( ,sanatog5 are 9 *emical comb9ation1 ! comp\nd _c h any effect on ! organism diff]5t f t ( ! uncomb9$ case9 & glyc]ophosphate1 = ! union mu/ be ( ! loose/ k9d & mu/ be brok5 up z soon z ! prep>ation ent]s ! dige/ive tract4 ,te/imonials are publi%$ 9 ! ,sanatog5 8lit]ature0 :i* %[ results 9 a v>iety ( conditions2 c]ebral concussion1 alcoholic ga/ritis1 anemia1 etc4 ,! pati5t is giv5 a *ance to recov] ) re/1 prop] diet--& ,sanatog54 ,& ! recov]y :i* ensues is attribut$ to ,sanatog56 ,n all ( ^! te/imonials are z naive z t ( ! ,"r ,rev]5d ! ,bi%op ( ,ba? & ,wells1 :o contributes ! foll[+ bit ( second-h& te/imony3 8,y may l to he> t ,i am in=m$ by my private secret>y t a memb] ( 8 family has d]iv$ v rem>kable b5efit f us+ ,sanatog540 ,illu/ration3 ,above is a photographic reproduction ( "o ( ! exhibits made at ,atlantic ,city at ! la/ annual meet+ ( ! ,am]ican ,m$ical ,association4 ,j> #a conta9s #c-a_/c ounces ( ! case9-glyc]ophosphate comb9ation made abroad & sold "u ! "n 8,sanatog520 x co/s ,"o ,doll>4 ,j> #b conta9s #b p\nds #ac-a_/b ounces ( a case9-glyc]ophosphate comb9ation made by an ,am]ican case9 company2 x co/s ,"o ,doll>4 ,= ! same money1 !n1 "o gets ne>ly #ae times z mu* ( ?is case9-glyc]ophosphate comb9ation made 9 ,am]ica z :5 ! case9-glyc]ophosphate comb9ation is sold "u ! "n 8,sanatog50 & manufactur$ abroad4 ,j> #c conta9s "o doll>'s wor? ( pure case94 ,! case9 entirely fills ! j>1 al?\gh ! weight ( ! mat]ial is ! same z ! weight ( ! case9-glyc]ophosphate comb9ation 9 ,j> #b4 ,pure case9 is m bulky ?an ! case9-glyc]ophosphate comb9ation4 ,aga9 we w\ld emphasize t ! *ief objection to ,sanatog5 is n its high price1 b ! fraudul5t claims "u :i* x is sold4 ,! foll[+ selections p]haps fairly repres5t ! value to sci5ce ( ! cl9ical evid5ce (f]$4 ,describ+ a case ( vomit+ f c]ebral concussion3 8,i ord]$ an ice-bag to ! head1 a mu/>d leaf to ! epiga/rium1 absolute recumb5cy 9 b$ & small fe$s ( ,sanatog5 ) wat]4 ,?is diet 0 cont9u$ = ?ree days1 b ! vomit+ ceas$ ! second day40 ,& "h a case ( 8hungry tir$ n]ves03 8,i h j _h a recov]y 9 a rem>kable case :i* scores a victory = ,sanatog54 ,! pati5t1 a man #fc1 _h be5 treat$ = "s ye>s pa/ = he>t tr\ble4 ,:5 he came to me1 h[ev]1 ,i diagnos$ 8 tr\ble z #8hungry tir$ n]ves4' ,i put him on ,sanatog5 & eupeptics4 ,9 a mon? he 0 mu* improv$40 ,9 a s]i\s case ( ! 8,am]ican disease03 8,i tri$ ,sanatog5 on a woman suff]+ f extreme neura/h5ia & debility4 ,= ! pa/ six weeks ,i h _h1 & /ill h1 h] "u re/-cure treatm5t1 dur+ :i* "t ,i h giv5 h] ,sanatog54 ,i h be5 v mu* elat$ ) ! treatm5t40 ,anemia 9 a girl ( #bc work+ 9 a bookb9d]y3 8,i promptly decid$ to use ,sanatog54 ,9 addition1 ,i 0 able to secure ! girl's abs5ce f "w s t %e _h ! advantage ( outdoor life & sun%9e4 ,improvem5t 0 rapid4444 ,bo? a priori & f results obta9$ x seems almo/ ju/ifiable to speak ( ,sanatog5 z a specific 9 ord9>y uncomplicat$ anemia40 ,note t 9 all ^! cases two or m rem$ial factors 7 introduc$1 yet any favorable result is promptly ascrib$ to only "o factor1 ,sanatog56 ,& ! factor ( spontane\s improvem5t irrespective ( all rem$ial measures is also ignor$4 ,a 8,,sci5tific0 ,,te/imonial ,e physician kn[s t ! k9d ( evid5ce j quot$ has ! same sci5tific value z t ( ! av]age 8pat5t m$ic9e0 te/imonial--none :atev]4 ,! exploit]s ( ,sanatog5 put =w>d "s te/imony1 h[ev]1 t purports to h a c]ta9 au?ority4 ,?is is a /atem5t to ! effect t 8,sanatog5 acts z a /rong /imulus z f> z ! recup]ative p[]s ( ! blood are conc]n$40 ,?is claim is bas$ on biologic exp]im5ts c>ri$ out by two physicians1 ,drs4 ,g4 ,mann & ,j4 ,g4 ,gage1 ! record ( ^: "w 0 publi%$ 9 ! ,lancet1 ,oct4 #ai1 #aiab4 ,! article ( ,mann & ,gage 0 gone ov] ) "s c>e & ! exp]im5ts !re describ$ did n seem to ju/ify ! conclusions rea*$ by ! au?ors4 ,z x _h be5 publi%$ 9 ! ,lancet1 a m$ical j\rnal ( /&+1 ^: publi%]s app>5tly ?\ght x ( suffici5t importance to w>rant ! exp5se ( a color$ plate ins]t1 x seem$ wor? :ile to h ! "w ( ,mann & ,gage review$ & its conclusions *eck$ by p>allel exp]im5ts4 ,a4 ,j4 ,c>lson1 pr(essor ( physiology at ! ,univ]sity ( ,*icago1 0 ask$ to d ?is "w & k9dly und]took x4 ,8 report foll[s3 ,report ( ,pr(essor ,c>lson ,i am ask$ to review ! "w done by ,drs4 ,g4 ,mann & ,j4 ,g4 ,gage1 f :i* !y draw ! foll[+ conclusions3 8,sanatog5 sodium case9og5ate glyc]ophosphates fur!r /imulates blood cells to und]go nucle> division1 :i* dur+ ! e>ly p]iod is mo/ly amitotic4444 ,!re=e1 x is evid5t t ,sanatog5 acts z a /rong /imulus z f> z ! recup]ative p[]s ( ! blood are conc]n$40 ,?ree s]ies ( exp]im5ts 7 made & report$ by ,drs4 ,mann & ,gage1 comp>+ ! hi/ology ( ! blood 9 />vation & dur+ ! height ( dige/ion4 ,! exp]im5ts ( ! fir/ s]ies 7 made on six /ud5ts1 ! />vation p]iod be+ ?irty-six h\rs1 ord9>y food be+ tak5 aft] ! ?irty-six h\rs' fa/1 s f> z c be ga!r$ f ,dr4 ,mann's report4 ,x 0 f\nd t dur+ ! height ( dige/ion ! nuclei ( ! lymphocytes & leukocytes /a9 m deeply1 & t !re is a slight decrease 9 ! cytoplasm & consequ5t dim9ution 9 ! size & numb] ( ! granules ( ! neutrophil & ! eos9ophil cells1 9 comp>ison ) ! blood dur+ fa/+4 ,! exp]im5ts ( ! second s]ies 7 made on #ajj frogs t _h />v$ = mon?s1 blood-films be+ tak5 at v>y+ p]iods aft] fe$+ #a gm4 ,sanatog54 ,! *anges not$ 9 ! :ite blood-cells ( ! frogs 7 practically id5tical ) ^? describ$ 9 ! case ( ! six /ud5ts4 ,increas$ cell division is /at$ to occur4 ,! nuclei ( ! ery?rocytes /a9 m deeply & ! cells are increas$ 9 size1 & exhibit increas$ cell division tw5ty-f\r h\rs aft] ! fe$+4 ,! ?ird s]ies consi/$ ( "o exp]im5t on ,dr4 ,mann himself4 ,he fa/$ tw5ty h\rs & !n took #ae gm4 ( ,sanatog5 9 a cup ( wat]4 ,practically ! only *ange not$ 9 ! blood aft] ! fe$+ 0 a deep] /a9+ ( ! nuclei ( ! :ite cells4 ,to quote3 8,! *anges 9 ! granules ( ! polymorphonucle> leukocytes & 9 ! eos9ophils 7 mu* less m>k$ ?an 9 ! specim5s suppli$ by ! /ud5ts1 & ! dim9ution 9 ! size ( ! :ite cells 0 s insignificant z to be h>dly noticeable40 ,assum+ t ! blood-*anges report$ are correct1 is ! conclusion w>rant$ t ,sanatog5 is a p[]ful recup]ative /imulant to ! blood8 ,9 ! fir/ place1 x rema9s to be prov$1 = !re is z yet positively no evid5ce1 t ! deep] /a9+ ( ! nuclei dur+ dige/ion & absorption ( a prote9 meal repres5ts 8recup]ative p[] ( ! blood0 or processes ( 8fe$+0 on ! "p ( ! :ite cells4 ,! actual significance ( ^! *anges requires fur!r inve/igation4 ,! increas$ division ( ! blood-cells describ$ by ,dr4 ,mann 9 ! frogs 0 n obs]v$ by him 9 man4 ,?is ph5om5on 9 ! frogs is1 9 all probability1 associat$ ) ! extraord9>y l5g? ( ! />vation p]iod 7mon?s7 & ! well-kn[n seasonal v>iations 9 ! physiology ( ?is species4 ,9 ! second place1 waiv+ = ! mom5t ! "q ( ! significance ( ! blood-*anges obs]v$1 ! evid5ce1 s f> z x goes1 po9ts to ! conclusion t ! great] aff9ity ( ! nuclei ( ! :ite cells = ! /a9 is br\ght ab\t by ! fe$+ ( any prote9 food4 ,! exp]im5ts d n demon/rate any diff]5t or m m>k$ effect f ,sanatog5 ?an f o!r prote9 foods4 ,! te/ on ! six /ud5ts ) ord9>y food c be consid]$ z a control on ! s+le ,sanatog5 te/ on ,dr4 ,mann himself4 ,! blood-*anges 9 ! /ud5ts 7 m m>k$ ?an 9 ,dr4 ,mann4 ,al?\gh ,mann & ,gage say t six frogs 7 us$ z controls1 !y d n say h[ ! controls 7 treat$1 or draw any comp>isons betwe5 ! controls & ! frogs f$ ) ,sanatog54 ,s f> z ! report goes1 !re=e1 ! only basis = comp>ison is af=d$ by ! "w ( "o ( ,dr4 ,mann's pupils1 ,h4 ,g4 ,butt]field4 ,?is work]1 z quot$ by ,mann1 f\nd t on fe$+ newts aft] two weeks' />vation ) a worm ! size ( a wood5 mat*1 ! nuclei ( all tissues 7except+ n]ve cells7 take a mu* deep] /a9 ?an 9 ! control animals4 ,to pron\nce ,sanatog51 on ! basis ( ! facts report$1 a 8p[]ful /imulus0 to blood-=mation is a piece ( special plead+1 if n ( d[nright dis+5u\sness4 ,consid]$ on its own m]its1 ! "w w\ld n h appe>$ to me wor?y ( be+ repeat$ = ! purpose ( *eck+ up su* obvi\sly unw>rant$ conclusions4 ,9 ord] to comply ) ! reque/ made ( me1 h[ev]1 ,i h repeat$ ,dr4 ,mann's exp]im5ts3 ,,exp]im5ts ,,by ,,pr(essor ,,c>lson ,i4 ,,te/s ,,on ,,man 7,a4 ,j4 ,c47 #a4 ,?irty-six h\rs' fa/ foll[$ by a meal ( #be gm4 ,sanatog5 9 wat]4 #b4 ,?irty-six h\rs' fa/ foll[$ by a meal ( #be gm4 case9 9 wat]4 #c4 ,?irty-six h\rs' fa/ foll[$ by a meal ( #bjj c4c4 ( milk4 ,,ii4 ,,te/s ,,on ,,rats #a4 ,f\r animals1 sev5ty-two h\rs' fa/ foll[$ by a meal ( ,sanatog5 9 wat]4 #b4 ,two animals1 sev5ty-two h\rs' fa/ foll[$ by a meal ( crack]s & milk4 #c4 ,two animals1 sev5ty-two h\rs' fa/ foll[$ by a meal ( case9 9 wat]4 #d4 ,two animals1 sev5ty-two h\rs' fa/ foll[$ by a meal ( case9 & sodium glyc]ophosphate 9 wat]4 ,blood-films 7 tak5 at int]vals dur+ ! fa/+ p]iod & = tw5ty-f\r h\rs aft] fe$+ 0 resum$4 ,! te*nic ( fix+ & /a9+ giv5 by ,drs4 ,mann & ,gage 0 foll[$ 9 e detail 9 ord] to make my results comp>able ) _! f9d+s4 ,,results ,my results may be summ>iz$ z foll[s3 #a4 ,! only *ange 9 ! blood-cells t c\ld be detect$ ) c]ta9ty 9 rats or 9 man1 aft] fe$+ ) ,sanatog5 or aft] fe$+ ) o!r foods1 0 a deep] /a9+ ( ! nuclei ( ! :ite cells 9 ! films tak5 aft] fe$+ z comp>$ ) ! films tak5 dur+ fa/+4 ,?is diff]5ce is g5]ally di/9ct1 & unmi/akable1 al?\gh individual cells c always be f\nd 9 ! fa/+ & ! fe$+ prep>ations t %[ no diff]5ce 9 aff9ity = ! dyes4 ,to ?is ext5t my results confirm ^? ( ,mann & ,gage4 ,i 0 n able1 h[ev]1 to make out any con/ant diff]5ce 9 ! size ( ! cells1 quantity ( cytoplasm1 or size & numb] ( cytoplasmic granules simil> to ^? report$ by ,mann & ,gage4 #b4 ,!re 0 no diff]5ce 9 ! aff9ity = /a9s on ! "p ( ! :ite blood-cells 9 films tak5 aft] fe$+ ,sanatog5 & ^? tak5 aft] fe$+ milk1 crack]s1 case91 & case9 & sodium glyc]ophosphate4 ,?is is true = ! te/s bo? on man & on rats4 #c4 ,! above-m5tion$ diff]5ce 9 ! /a9+ ( ! cell nuclei 0 some:at m m>k$ 9 ! te/s on rats ?an 9 ! te/s on man1 probably ow+ to ! long] />vation p]iod 9 ! case ( rats4 ,x has already be5 /at$ t ! significance ( ?is increas$ aff9ity = dyes 9 ! nuclei ( ! :ite blood-cells mu/ be det]m9$ by fur!r inve/igation4 ,x may be relat$ to ! *ange 9 ! titration alkal9ity ( ! blood r ?an an evid5ce ( 8recup]ative p[]0 on ! "p ( ! blood1 z x is well kn[n t />vation induces acidosis1 :ile dur+ dige/ion ! alkal9ity ( ! blood is di/9ctly increas$4 ,if we assume t increas$ /a9+ reaction dur+ dige/ion indicates 8increas$ recup]ative p[] ( ! blood0 x foll[s t su* common & inexp5sive foods z milk1 crack]s & case9 are j z 8p[]ful /imuli0 to ?is recup]ation z ,sanatog54 ,! ext5sive rese>*es ( ,m5del & ,osborne h %[n t case9 is 9 a c]ta9 s5se a p]fect food 9 t x is1 9 normal animals1 capable ( promot+ gr[? & ma9ta9+ nitrog5\s equilibrium1 at lea/ = long p]iods ( "t4 ,! burd5 ( pro(1 h[ev]1 re/s ) ! promot]s ( ,sanatog5 to %[ t ! case9 9 ,sanatog5 is sup]ior to ! natural product ( ! c[4 ,conclusion ,f ! f9d+s 9 ,pr(essor ,c>lson's report on ?is disguis$ puff ( a m5daci\sly exploit$ propriet>y1 ab\t all t rema9s to be said is t x is humiliat+ to f9d su* pseudo-sci5ce1 n only built up by memb]s ( a pr(ession tra9$ 9 sci5ce1 b also giv5 curr5cy & au?ority by a m$ical j\rnal ( high /&+4--7,f ! ,j\rnal ,a4 ,m4 ,a41 ,sept4 #bf1 #aiad47 ,z to ,sanatog5 ,= sev]al ye>s x has be5 kn[n by physiologi/s t all prote9s tak5 into ! /oma* are dis9tegrat$ into _! fundam5tal compon5ts1 ! am9o-acids1 & t !y are n absorb$ at all z prote9s1 except 9 mo/ m9ute am\nts "u exceptional conditions4 ,!re=e1 no matt] :at prote9 is tak5 z food1 ! mat]ial obta9$ f ?is prote9 by ! body is a gr\p ( am9o-acids1 always pretty mu* ! same except 9 relative proportions1 :atev] ! food4 ,a few prote9s lack c]ta9 ess5tial am9o-acids1 b any ord9>y diet supplies en\gh1 & m ?an en\gh1 ( ea* & e am9o-acid4 ,fur!rmore1 s9ce ! prote9s are completely dis9tegrat$ be=e absorption1 x foll[s t any adv5titi\s *emical sub/ance t is b\nd to a prote9 tak5 9 ! food does n ent] ! blood & circulate 9 ! body 9 ! same prote9 comp\nd4 ,all ! facts /at$ above are elem5t>y1 & %\ld be kn[n by any & e physician :o pret5ds to keep ev5 approximately abrea/ ( ! sci5ce ( m$ic9e4 ,if !re are any :o d n "k ^! fundam5tals1 & f c]ta9 unwelcome evid5ce we fe> !re are1 !y mu/ be resign$ to be+ told j :]e !y /&4 ,c]ta9ly !y h no good excuse = _! lack ( in=mation1 = ! physiologi/s & bio*emi/s h in=m$ !m ( mod]n advances 9 innum]able ways4 ,= t5 ye>s & m ^! facts h be5 discuss$ & demon/rat$ 9 societies & 9 m$ical publications4 ,& yet--!re is ,sanatog51 prescrib$ by ,geheimrats1 ,h(rats & also by doctors1 & te/imonial$ z abundantly by m5 ) m$ical degrees z ,duffy's :isky is by c5t5>ians4 ,"o c m]ely ?r[ up 8 h&s4 ,if1 z ! exploit]s ( ,sanatog5 decl>e1 ! product 8has be5 endors$ by von ,noord51 ,ewald1 ,duhrss51 ,eul5burg1 ,neis]1 ,b9swang]1 ,leyd51 ,krafft-,eb+1 ,tillmanns1 ,tunnicliffe & ?\s&s ( o!r e>ne/1 reputable physicians10 we c only say t _! e>ne/ness has n be5 9 ! direction ( grasp+ fundam5tal advances 9 m$ical sci5ces1 h[ev] great ! reputation !y h ga9$ may be4 ,! article by ,john ,phillips ,/reet t foll[s is ano!r report ( exact exp]im5tal obs]vation :i* %[s1 z 0 obvi\s be=eh&1 t ,sanatog5 has ! prop]ties ( its con/itu5ts1 namely1 case9 & glyc]ophosphates4 ,no?+ m nor no?+ less c\ld be ! case4 ,bottl+ dri$ cottage *eese plus "s glyc]ophosphates1 & rais+ ! price _m times1 may increase its psy*ic effect1 b x w n alt] its physiologic action4 ,^! facts we h pres5t$ (t5 en\gh1 b ! am\nt ( paid adv]tis+ ! proprietors ( ?is comp\nd f9d x pr(itable to c>ry 9 ! ,unit$ ,/ates makes u feel oblig$ to give !m ?is bit free4 ,t laym5 may be p]suad$ to pur*ase ,sanatog5 9 ! belief t x possesses "s occult p[]s n to be f\nd 9 its con/itu5ts is n surpris+4 ,by blatant & p]si/5t adv]tis+1 ! public c be fool$ into buy+ any product--h[ev] valueless--= :i* m$ic9al claims are made4 ,b t physicians %\ld prove equally gullible is a sorry comm5t>y on ! sci5tific atta9m5ts ( ! foll[]s ( a le>n$ pr(ession4--7,modifi$ f ,editorial 9 ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #ba1 #aiad47 ,,! ,,fe$+ ,,value ,,( ,,sanatog5 ,,comp>$ ,,) ,,comm]cial ,,case9 ,,) ,,respect ,,to ,,ma9t5ance ,,& ,,gr[? ,john ,phillips ,/reet1 ,m4,s4 ,*emi/ ,connecticut ,agricultural ,exp]im5t ,/ation ,,new ,,hav51 ,,conn4 ,! propriet>y prep>ation 8,sanatog50 is claim$ to consi/ ( ab\t #ie p] c5t4 case9 & #e p] c5t4 sodium glyc]ophosphate4 ,! analysis ( ,c4 ,b4 ,morison#abb is z foll[s3 #abb ,morison1 ,c4 ,b43 ,rept4 ,conn4 ,agri4 ,exp]4 ,/ation1 #aiab1 p4 #aig4 ,wat] #i4ig ,total nitrog5 #ab4ha ,nitrog51 ppt4 by acetic acid #ab4ed ,case9 #hj4ja ,e!r extract #j4aa ,a% #e4ei ,sulphur1 total #j4gc ,sulphur 9 case9 #j4fd ,phosphorus1 total #a4di ,phosphorus 9 case9 #j4fi ,phosphorus 9 inorganic =m #j4aa ,9 connection ) ! above analysis x 0 demon/rat$ t sodium glyc]ophosphate 0 pres5t4 ,sanatog51 !re=e1 consi/s ess5tially1 on ! wat]-free basis1 ( ab\t #ij p] c5t4 case9 & #e p] c5t4 sodium glyc]ophosphate1 ) a small am\nt ( an unid5tifi$ nitrog5\s comp\nd conta9+ bo? sulphur & phosphorus1 & a small am\nt ( phosphorus 9 organic comb9ation4 ,! manufactur]s claim t ! two ess5tial +r$i5ts exi/ 9 ,sanatog5 z a def9ite *emical comp\nd4 ,c]ta9 au?orities1 on ! o!r h&1 h insi/$ t ! case9 & glyc]ophosphate h n be5 *emically comb9$ & t ,sanatog5 is simply a me*anical mixture ( ! two4 ,:i* claim is correct we w n consid] "h1 = inde$ x is ( little importance1 = :e!r or n *emically comb9$ ! action ( ! dige/ive fluids ( ! body w\ld spe$ily break d[n ! alleg$ comp\nd into its con/itu5ts1 & ! body w\ld h case9 & ! glyc]ophosphate (f]$ = its use1 j ! same z ?\gh !y _h be5 (f]$ z a m]e me*anical mixture4 ,x be+ app>5t t ,sanatog5 consi/s almo/ entirely ( case9 & sodium glyc]ophosphate1 ! =m] well-kn[n +r$i5t mak+ up n9e-t5?s ( its weight1 ! "q naturally arises h[ a mixture ( ^! two common sub/ances c acquire1 simply by t admixture1 unusually valuable prop]ties n possess$ by ! two compon5ts4 ,lead+ physiologi/s q g5]ally agree t phosphorus 9 ! =m ( glyc]ophosphates influ5ces metabolism v little4 ,fur!rmore1 x is obvi\s t ! food value ( ! small am\nt ( glyc]9 pres5t mu/ be slight4 ,x is app>5t !re=e1 t :atev] nutrim5t or en]gy ,sanatog5 supplies mu/ be dep5d5t on its ma9 con/itu5t case94 ,sanatog5 is commonly sold at retail 9 #ajj gm4 or #bjj gm4 packages = #a & #a4ij1 respectively4 ,x is possible t 9 l>g] quantities ^! prices might be %ad$ some:at1 b ! fact rema9s t ! ord9>y retail pur*as] ( ,sanatog5 pays = x ab\t #a c5t p] gram1 or ab\t #d4ej p] p\nd4 ,if ! value ( ,sanatog5 dep5ds on its case91 "o might ask1 9 all fairness1 :y %\ld ! pati5t pay #d4ej p] p\nd = ,sanatog5 :5 he c secure ord9>y comm]cial case9 = #h4e to #aj c5ts p] p\nd6 7,! ,case9 ,mfg4 ,co4 ( ,new ,york quot$ to me _! ,no4 #fj case9 at #aj c5ts p] p\nd 9 #e-p\nd lots1 #h4e c5ts p] p\nd f4 o4 b4 ,ba9bridge1 ,n4 ,y41 9 #ajj-p\nd lots1 & #h4e c5ts p] p\nd1 freight paid1 9 #ejj-p\nd lots47 ,i h pur*as$ ,sanatog5 f a :olesale druggi/ at ! rate ( #b4ge = #djj gm41 or #c4ab p] p\nd1 s t "u ! mo/ favorable conditions ! co/ ( ,sanatog5 is m ?an ?irty times z great z ! comm]cial case9 9 "q4 ,is ! consum] ju/ifi$ 9 pay+ ?is exce$+ly high price = purifi$ case98 ,! foll[+ fe$+ exp]im5ts 7 c>ri$ out to answ] ?is qu]y4 ,,fe$+ ,,exp]im5ts ,:ite rats 7 *os5 = ! exp]im5tal animals because ( _! adaptability = te/s ( ?is k9d1 z %[n by ! ext5d$ successful exp]i5ce ( ,osborne & ,m5del1 & also because1 by us+ :ite rats1 ,i c\ld take advantage ( ! equipm5t & ! exp]i5ce ( my colleagues1 ,dr4 ,t4 ,b4 ,osborne1 ,pr(4 ,l4 ,b4 ,m5del & ,miss ,edna ,l4 ,f]ry4 ,! value ( ,sanatog5 z comp>$ ) comm]cial case9 0 /udi$ f two po9ts ( view3 #a4 ,its value 9 ma9ta9+ ! weight ( mature rats4 #b4 ,its value 9 promot+ ! gr[? ( "y rats4 ,i4 ,,! ,,ma9t5ance ,,( ,,weight ,,( ,,mature ,,rats ,! ,sanatog5 us$ conta9$ #ab4hh p] c5t4 ( nitrog51 & ! case91 #ab4hb p] c5t41 s t f ! po9t ( view ( nitrog5 cont5t !y 7 practically equival5t1 gram = gram4 ,six heal?y male animals 7 select$1 ,rats #a1 #b & #c be+ f$ ! case9 ration & ,rats #d1 #e & #f ! ,sanatog5 ration4 ,at ! beg9n+ ( ! exp]im5t ! case9 rats 7 #beg1 #cfj & #cgf days old2 ! ,sanatog5 rats1 #bdi1 #cba & #bge days old1 respectively4 ,^! weight conditions1 if any?+1 slightly favor$ ! ,sanatog5 rats1 z !y 7 slightly less mature1 & a great] gr[? might naturally be expect$4 ,! rations f$ _h ! foll[+ p]c5tage composition3 ,ration #a ,ration #b ,case9 #bj ,sanatog5 #bj ,prote9-free milk,,ba #bh ,prote9-free milk,,ba #bh ,l>d #h ,l>d #ad ,unsalt$ butt] #ah ,unsalt$ butt] #ah ,corn />* #bf ,corn />* #bj ,,ba ,osborne & ,m5del3 ,fe$+ ,exp]im5ts ) ,isolat$ ,food ,sub/ances1 ,c>negie ,in/4 ( ,wa%+ton1 ,publ4 #aef1 #aiaa1 ,"p #b1 p4 #hj4 ,! rats 7 weigh$ twice a week = n9e weeks1 a record ( ! food consum$ also be+ kept4 ,table #a %[s ! weekly weights ( ! case9 rats1 ! weekly ga9 or loss1 & ! weekly consumption ( food4 ,table #b gives simil> data = ! ,sanatog5 rats4 ,illu/ration3 ,*>t #a4--;,gr[? curves ( ,rats #a1 #b & #c1 on ,ration #a3 ,case94 ,illu/ration3 ,*>t #b4--;,gr[? curves ( ,rats #d1 #e & #f1 on ,ration #b3 ,sanatog54 ,c]ta9ly ! above data %[ no sup]iority ( ,sanatog5 ov] comm]cial case94 ,9 fact ! results might be tak5 to sugge/ a slight advantage = ! *eap] article1 if "o 7 w>rant$ 9 draw+ f9e di/9ctions f a limit$ numb] ( animals4 ,to conclude1 a comp>ative fe$+ ( six male :ite rats dur+ n9e weeks %[$ no nutritive sup]iority ( ,sanatog51 co/+ #c4ab p] p\nd1 ov] comm]cial case9 co/+ #aj c5ts p] p\nd4 ,,ii4 ,,! ,,promotion ,,( ,,gr[? ,,9 ,,"y ,,rats ,9 ! second s]ies ( exp]im5ts t5 male rats 7 us$ ) f\r diff]5t rations4 ,9 ^!1 case9 & ,sanatog5 7 comp>$1 us+ bo? ,osborne & ,m5del's 8prote9-free milk0 & _! 8artificial prote9-free milk ,,iv40#abc ,butt] fat 0 also sub/itut$ = ! unsalt$ butt] us$ 9 ,rations #a & #b4 #abc ,osborne & ,m5del3 ,j\r4 ,biol4 ,*em41 #aiac1 xv1 #cag4 ,! p]c5tage composition ( ! rations f$ 0 z foll[s3 ,ration #c ,ration #e ,case9 #bj ,case9 #bj ,prote9-free milk #bh ,artificial p4-f4 milk ,,iv #bi ,l>d #h ,l>d #h ,butt]-fat #ah ,butt]-fat #ah ,corn />* #bf ,corn />* #be ,ration #d ,ration #f ,sanatog5 #bj ,sanatog5 #bj ,prote9-free milk #bh ,artificial p4-f4 milk ,,iv #bi ,l>d #ad ,l>d #ad ,butt]-fat #ah ,butt]-fat #ah ,corn />* #bj ,corn />* #ai ,two male rats 7 us$ ) ea* ( ,rations #c & #d1 & ?ree ) ea* ( ,rations #e & #f4 ,!y 7 all heal?y "y rats rang+ f #eg to #ga days old4 ,z 9 ! fir/ s]ies ( exp]im5ts ! rats 7 weigh$ twice a week & a record kept ( ! food consum$4 ,rations #c & #d 7 f$ = sev5ty-sev5 days1 ,rations #e & #f = ?irty-five days4 ,table #c %[s ! weekly weights & ga9s or losses ( ! rats f$ ,rations #c & #d4 ,rat #h suff]$ m or less f di>rhea dur+ a consid]able "p ( ! exp]im5t1 cov]+ a p]iod f ,m>* #af to ,april #i1 & f ,april #ac to ,may #aa4 ,! food intake correspond+ly decreas$ dur+ ^? p]iods4 ,,table #a4--,,weights ,,( ,,case9 ,,rats1 ,,on ,,ration ,,no4 #a1 ,,ov] ,a ,,p]iod ,,( ,,n9e ,,weeks,,bb ,rat #a ,rat #b ,rat #c ---------------------------------------- --------------- ,date ,weight1,ga9 ,food ,weight1,ga9 ,food ,weight1,ga9 ,food gm4 or ,eat51 gm4 or ,eat51 gm4 or ,eat51 ,loss1 gm4 ,loss1 gm4 ,loss1 gm4 gm4 gm4 gm4 ---------------------------------------- ---------------------- #a_/b #bdj4j -- -- #bfd4f -- -- #cad4a -- -- #a_/i #bej4h #aj4h #gc4g #bgj4i #f4c #he4b #cad4f #j4e #ie4g #a_/af #bfd4c #ac4e #hi4c #bhd4i #ad4j #ii4b #cjh4g -#e4i #aag4i #a_/bc #bgd4i #aj4f #ij4g #bic4e #h4f #ajg4g #cac4h #e4a #aaf4e #a_/cj #bgh4f #c4g #hj4b #cjd4e #aa4j #ajj4e #cbb4b #h4d #aaf4g #b_/f #bgh4c -#j4c #hb4d #bid4b -#aj4c #ig4j #caa4b -#aa4j #aai4i #b_/ac #bhh4g #aj4d #he4e #bha4e -#ab4g #id4b #cjh4b -#c4j #abe4f #b_/bj #bhf4d -#b4c #hf4a #bic4c #aa4h #hf4h #cji4j #j4h #abf4h #b_/bg #bhg4f #a4b #ha4a #big4f #d4c #ajj4g #cjc4d -#e4f #abi4c #c_/f #bib4f #e4j #hj4a #cjg4d #i4h #ajc4a #bib4d -#aa4j #aja4j ,total -- #eb4f #gei4a -- #db4h #hgd4d -- -#ba4ga1jdi4d ,av]age p] week -- #e4h #hd4c -- #d4h #ig4b -- -#b4d #aaf4f ---------------------------------------- ---------------------- ,,bb ,! gr[? curves ( ,rats #a1 #b & #c are giv5 9 ,*>t #a4 ,,table #b4--,,weights ,,( ,,sanatog5 ,,rats1 ,,ration ,,no4 #b1 ,,ov] ,a ,,p]iod ,,( ,,n9e ,,weeks,,bc ,rat #d ,rat #e ,rat #f ---------------------------------------- -------------- ,date ,weight1,ga9 ,food ,weight1,ga9 ,food ,weight1,ga9 ,food gm4 or1 ,eat51 gm4 or ,eat51 gm4 or ,eat51 ,loss gm4 ,loss1 gm4 ,loss1 gm4 gm4 gm4 gm4 ---------------------------------------- --------------------- #a_/b #bea4h -- -- #bij4f -- -- #bid4j -- -- #a_/i #beg4a #e4c #gc4d #big4b #f4f #hf4c #bhi4a - #d4i #eh4d #a_/af #bfb4d #e4c #hi4h #bib4d - #d4h #hh4i #bhf4a - #c4j #gf4h #a_/bc #bgd4d #ab4j #ig4c #bie4g #c4c #ib4h #bhg4f #a4e #he4h #a_/cj #bhb4g #h4c #ie4e #bii4e #c4h #ib4c #bih4f #aa4j #ij4i #b_/f #bgi4h - #b4i #ig4g #bhd4b -#ae4c #hg4g #bib4i - #e4g #hi4h #b_/ac #bga4b - #h4f #if4a #bhj4j - #d4b #id4i #bie4a #b4b #ii4g #b_/bj #beg4e -#ac4g #ia4f #bgd4i - #e4a #if4d #bif4j #j4i #ic4i #b_/bg #beh4j #j4e #ic4e #bgc4j - #a4i #ajc4c #bie4j - #a4j #ie4a #c_/f #bgj4i #ab4i #id4h #bgh4a #e4a #id4i #cjf4c #aa4c #hi4d ,total -- #ai4ahbi4g -- -#ab4e #hcg4e -- #ab4c #ggi4h ,av]age #b4g p] week -- #ib4b -- - #a4d #ic4a -- #a4d #hf4f ---------------------------------------- --------------------- ,,bc ,! gr[? curves ( ,rats #d1 #e & #f are giv5 9 ,*>t #b4 ,,table #c4--;,,comp>ative ,,weights ,,( ,,rats ,,f$ ,,rations #c ,,& #d ,weights ( ,rats1 ,ration #c1 ,weights ( ,rats1 ,ration #d1 ,case91 ,prote9-,free ,milk ,sanatog51 ,prote9-,free ,milk ---------------------------------------- ----------------- ,rat #g ,rat #h ,rat #i ,rat #aj ,date ---------------------------------------- ------------ ,weight1,ga9 ,weight1,ga9 ,weight1,ga9 ,weight1,ga9 gm4 or gm4 or gm4 or gm4 or ,loss1 ,loss1 ,loss1 ,loss1 gm4 gm4 gm4 gm4 ---------------------------------------- ----------------- #c_/i #adb4b -- #ajh4j -- #abg4h -- #ajg4j -- #c_/af #aeb4h #aj4f #abj4c #ab4c #abi4a #a4c #aaf4j #i4j #c_/bc #afe4g #ab4i #ace4a #ad4h #add4f #ae4e #acd4e #ah4e #c_/cj #agh4f #ab4i #adj4d #e4c #afj4j #ae4d #adi4h #ae4c #d_/f #ahg4h #i4b #adh4h #h4d #agc4a #ac4a #adc4h -#f4j #d_/ac #aih4e #aj4g #aeg4f #h4h #ahe4f #ab4e #aff4a #bb4c #d_/bj #bjd4f #f4a #afd4f #g4j #aid4h #i4b #agi4d #ac4c #d_/bg #baj4c #e4g #afg4b #b4f #bjd4f #i4h #aia4j #aa4f #e_/d #bbc4j #ab4g #agi4f #ab4d #bbb4i #ah4c #bjd4g #ac4g #e_/aa #bbc4f #j4f #aia4f #ab4j #bcf4d #ac4e #baj4h #f4a #e_/ah #bca4e #g4i #bjc4f #ab4j #bdj4j #c4f #bah4f #g4h #e_/be #bcg4d #e4i #bac4i #aj4c #bdg4c #g4c #bbf4g #h4a ,total -- #ie4b -- #aje4i -- #aai4e -- #aai4g ---------------------------------------- ----------------- ,! diff]5ce 9 ! ga9s 9 weight %[n by ! f\r rats are n great & c]ta9ly d n w>rant ! conclusion t ,sanatog5 possesses any m>k$ sup]iority ov] ! comm]cial case9 9 promot+ gr[?4 ,! slightly increas$ ga9s %[n by ,rats #i & #aj are entirely incomm5surate ) ! co/ ( ! ,sanatog54 ,all ( ! rats %[$ a vigor\s gr[? & exce$$ ! av]age weight expect$ = rats ( _! respective ages1 bas$ on ! long s]ies ( obs]vations ( ,osborne & ,m5del1 z %[n 9 ,table #d4 ,illu/ration3 ,*>t #c4--;,gr[? curves ( ,rats #g1 #h1 #i & #aj on ,rations #c1 ,case91 prote9-free milk1 & #d1 ,sanatog51 prote9-free milk4 ,,table #d4--,,weight ,,( ,,rats #g ,,to #aj ,,comp>$ ,,) ,,av]age ,,weight ,,( ,,rat ,,( ,,same ,,age ,av]age ,weight ,rat ,age 9 ,days ,f9al weight1 = rat ( gm4 ,same ,age1 gm4 ---------------------------------------- --------- #g #adh #bcg #bjd #h #ach #bad #bja #i #ade #bdg #bjd #aj #acd #bbg #aig ---------------------------------------- --------- ,illu/ration3 ,*>t #d4--;,gr[? curves ( ,rats #aa1 #ab & #ac1 on ,ration #e3 ,case91 artificial prote9-free milk4 ,illu/ration3 ,*>t #e4--;,gr[? curves ( ,rats #ad1 #ae & #af1 on ,ration #f3 ,sanatog51 artificial prote9-free milk4 ,,table #e4--,,weights ,,( ,,rats ,,f$ ,,ration #e1 ,,case91 ,,artificial ,,prote9-,,free ,,milk,,bd ,rat #aa ,rat #ab ,rat #ac ---------------------------------------- --------- ,date ,weight1,ga9 or ,weight1,ga9 or ,weight1,ga9 or gm4 ,loss1 gm4 gm4 ,loss1 gm4 gm4 ,loss1 gm4 ---------------------------------------- ---------------- #c_/i #acb4a -- #aaj4j -- #ii4j -- #c_/af #acj4d -#a4g #aaf4h #f4h #aaj4c #aa4c #c_/bc #acf4h #f4d #acj4h #ad4j #ajh4f -#a4g #c_/cj #acg4a #j4c #ach4j #g4b #ajj4b -#h4d #d_/f #abg4a -#aj4j #adc4i #e4i #ie4e -#d4g #d_/ac #aab4d -#ad4g #adc4f -#j4c #ij4j -#e4e ,total -- -#ai4g -- #cc4f -- -#i4j #d_/bj #adf4g #cc4g #agj4g #bg4a #ajd4j #ad4j ---------------------------------------- ---------------- ,,bd ,date #d_/bj cov]s use ( mix$ food4 ,rat #ac suff]$ m or less f di>rhea ?r\gh\t ! :ole exp]im5t1 & ,rat #af suff]$ simil>ly dur+ ! fir/ two weeks4 ,! results secur$ by ,rations #e & #f comp>$ ) ,rations #c & #d1 ! only diff]5ce be+ t natural prote9-free milk 0 us$ 9 ! latt] & artificial prote9-free milk 9 ! =m]1 are mo/ /rik+4 ,su* results 7 anticipat$ f ! exp]i5ce ( ,osborne & ,m5del 9 fe$+ simil> mat]ials4 ,all ( my rats1 except ,rat #ac1 a case9 rat1 %[$ a decid$ loss 9 weight aft] five weeks' fe$+ on rations conta9+ artificial prote9-free milk4 ,^! losses am\nt$ to #ai4g1 #i4j1 #bc4a1 #f4g & #bg4f gm41 :]eas rats f$ on ! same rations1 except = ! =m ( prote9-free milk1 ga9$1 dur+ ! same p]iod ( five weeks1 #ef4c1 #di4f1 #eg4h & #ei4a gm4 ,! fact t "o case9 ,,table #f4--,,weights ,,( ,,rats ,,f$ ,,ration #f4--,,sanatog51 ,,artificial ,,prote9-,,free ,,milk,,be ,rat #ad ,rat #ae ,rat #af ---------------------------------------- ----------- ,date ,weight1,ga9 or ,weight1,ga9 or ,weight1,ga9 or gm4 ,loss1 gm4 gm4 ,loss1 gm4 gm4 ,loss1 gm4 ---------------------------------------- ---------------- #c_/i #aah4d -- #aaa4c -- #aja4c -- #c_/af #abf4b #g4h #aaf4b #d4i #ajj4j -#a4c #c_/bc #abf4f #j4d #abc4d #g4b #ih4j -#b4j #c_/cj #abd4g -#a4i #abc4c -#j4a #ih4g #j4g #d_/f #aaj4b -#ad4e #aab4c -#aa4j #hh4g -#aj4j #d_/ac #ie4c -#ad4i #ajd4f -#g4g #gc4g -#ae4j ,total -- -#bc4a -- -#f4g -- -#bg4f #d_/bj #acj4c #ce4j #ace4c #cj4g #ajf4d #cb4g ---------------------------------------- ---------------- ,,be ,date #d_/bj cov]s use ( mix$ food4 rat f$ on ! artificial prote9-free milk %[$ a sub/antial ga9 is )\t significance1 z su* exceptions to ! g5]al rule occur occasionally1 &1 fur!rmore1 ?is rat also dur+ ! la/ week ( ! exp]im5t likewise lo/ weight4 ,! ext5t ( ^! losses comp>$ ) :at ! av]age normal male rat weighs at a correspond+ age is %[n 9 ,table #g4 ,,table #g4--,,weight ,,( ,,rats #aa ,,to #af ,,comp>$ ,,) ,,av]age ,,weight ,,( ,,rat ,,( ,,same ,,age ,av]age ,weight ,rat ,age1 ,days ,f9al ,weight1 ( ,rat ( gm4 ,same ,age1 gm4 ---------------------------------------- ------- #aa #ajf #aab #afg #ab #ajf #add #afg #ac #ii #ij #afb #ad #ajf #ie #afg #ae #ib #aje #aec #af #if #gd #aeh ---------------------------------------- -------- ,t ^! losses 9 weight 7 n due to any inh]5t weakness 9 ! rats is %[n by ! fact t by fe$+ ,rats #aa to #af = "o week aft] ! t]m9ation ( ! exp]im5t ) ,osborne & ,m5del's 8mix$ food0 7a mixture ( dog bread1 sunfl[] se$s1 vegetables & meat7 v l>ge ga9s 7 secur$ 9 e in/ance1 rang+ f #ad to #ce gm4 ,! gr[? curves = ,rats #g to #af are %[n 9 ,*>ts #c1 #d & #e4 ,to conclude1 ,a ,,comp>ative ,,fe$+ ,,( ,,f\r ,,male ,,:ite ,,rats ,,dur+ ,,elev5 ,,weeks1 ,,%[$1 ,,if ,,any?+1 ,a ,,slightly ,,great]1 ,,b ,,insignificant1 ,,increase ,,9 ,,weight ,,= ,,sanatog5 ,,ov] ,,comm]cial ,,case94 ,,9 ,a ,,ration ,,9 ,,:i* ,,artificial ,,_h ,,be5 ,,sub/itut$ ,,= ,,natural ,,prote9-,,free ,,milk1 ,,sanatog5 ,,%[$ ,,no ,,advantage ,,ov] ,,comm]cial ,,case9 ,,9 ,,*eck+ ,,! ,,failure ,,9 ,,weight ,,( ,,! ,,rats4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #ba1 #aiad47 ,,poehl',s ,,sp]m9 ,,9 ,,art]ioscl]osis ,a physician address$ ! foll[+ inquiry to ,! ,j\rnal3 8,9 a rec5t numb] ( ! ,gazette md4 belge1 ,i read a detail$ report ( five cases ( art]ioscl]osis 9 :i* ! pati5ts 7 all m>k$ly improv$ & "s ( !m app>5tly cur$ by a c\rse ( #8,sp]m9um ,poehl1' an adv]tis$ rem$y :i* ,i h always di/ru/$ & nev] prescrib$4 ,i am n[ suff]+ myself f a some:at advanc$ case ( art]ioscl]osis & w\ld l to try ?is rem$y if ! ,c\ncil has le>n$ any?+ 9 favor ( x & if !re is no reason to fe> bad effects f x40 ,x4 ,y4 ,z4 ,! ,j\rnal repli$3 ,app>5tly ! exploitation ( ,poehl's sp]m9 pass$ sev]al ye>s ago f ! doma9 ( exp]im5tal m$ic9e to t ( no/rums adv]tis$ to ! laity4 ,s f> z we "k1 x has receiv$ no rec5t discussion f reliable cl9icians or exp]im5t]s4 ,9 "s m$ical j\rnals1 z also 9 lay j\rnals1 x is true1 "o /ill reads t ,poehl's sp]m9 is successfully appli$ 9 8neura/h5ia1 s5ile m>asmus1 anemia1 ra*itis1 g\t1 *ronic rheumatism1 syphilis1 hy/]ia1 tub]culosis1 typhus1 diseases ( ! he>t1 nephritis1 tabes dorsalis1 p>alysis1 neura/h5ic impot5ce1 ov]work1 acute diseases1 & = convalesc5ts40 ,few quack adv]tisem5ts w\ld diff] mu* f ?is puff ( ,poehl's sp]m94 ,s f> z we "k1 !re is no reason to fe> injuri\s results f ! use ( ! rem$y2 nei!r might any good be expect$ f its use 9 art]ioscl]osis4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,april #ae1 #aiaa47 ,,syrup ,,( ,,cocillana ,,comp\nd ,a physician 9 a small t[n 9 ,nebraska writes3 8,9 look+ ov] a prescription file n long ago ,i f\nd a prescription :i* ,i copi$ & am s5d+ to y4 ,x is a good example ( %otgun prescrib+4 ,i d n give ! "n ( ! prescrib]1 & y w please n m5tion f :5ce ?is comes4 ,! doctor :o wrote ?is has _h ab\t t5 ye>s' exp]i5ce40 ,"h is ! prescription giv5 exactly z transmitt$ by our correspond5t3 ,sp4 /icta ,gtt xv ,sp4 ipecac ,gtt x ,sp4 bryonia ,gtt x ,sp4 macrotys i ,brom(orm ,bron*ial ,anodyne ii ,syrup ,cocillana ,comp4 q4 s4 ad vi ,teaspoonful e two or ?ree h\rs4 ,x is evid5t t ! prescrib] is an eclectic4 ,z a matt] ( fact1 9 a second lett] f ! physician :o =w>d$ ! prescription1 we are in=m$ t ! prescrib] is a graduate ( an eclectic in/itution n a ?\s& miles f :]e he practices4 ,! 8,sp40 9 ! prescription does n mean 8,spiritus10 b specific t9cture4 ,! prescrib] is an advocate ( specific rem$ies1 "o ( :i* %\ld fit ! condition1 b he is broad-m9d$ en\gh to call help f ! outside1 & s adds fifte5 o!r rem$ies to ! specific select$1 includ+ alcohol4 ,! inability ( "o m9d to rememb] all ! +r$i5ts ( s complex a mixture w expla9 ! fact t ipecac is duplicat$1 occurr+ bo? z a specific t9cture & z an +r$i5t ( ,brom(orm ,bron*ial ,anodyne4 ,! latt]1 ! manufactur]s tell u1 conta9s 9 "o fluid\nce3 ,alcohol #e p] c5t4 ,brom(orm #h drops ,ipecac #a_/b gr4 ,ammonium bromid #bd grs4 ,b5zo9 #a gr4 ,syrup ,cocillana ,comp41 "o ( ! 8elegant specialties0 ( ,p>ke ,davis ,co41 ( :i* !y c]ta9ly ought to be v pr\d1 conta9s1 we are told1 9 "o fluid\nce3 ,alcohol #e p] c5t4 ,h]o9 hydro*lorid #h_/bd gr4 ,t9ct4 ( euphorbia pilulif]a #abj m94 ,syrup ( wild lettuce #abj m94 ,t9ct4 ( cocillana #dj m94 ,syrup ( squill comp4 #bd m94 ,casc>91 ,p4 ,d4 ,co4 #h grs4 ,m5?ol #h_/ajj gr4 ,?is 8elegant specialty0 ( ,p>ke1 ,davis ,co4 is n only a %otgun prescription1 b has z "o ( its +r$i5ts a mixture itself conta9+ ?ree +r$i5ts1 namely3 ,syrup ,squill ,comp4 7,coxe's ,hive ,syrup71 mak+ t5 9 all--a beautiful example ( sci5tific ph>macy4 ,we wond] if our eclectic bro!r really appreciat$ t 8 prescription1 writt5 out1 w\ld be z foll[s3 ,sp4 /icta ,gtt xv ,sp4 ipecac ,gtt x ,sp4 bryonia ,gtt x ,sp4 macrotys i ,alcohol #e p] c5t4 ,brom(orm #h drops ,ipecac #a_/b gr4 ,ammonium bromid #bd grs4 ,b5zo9 #a gr4 ,alcohol #e p] c5t4 ,h]o9 hydro*lorid #h_/bd gr4 ,t9ct4 ( euphorbia pilulif]a #abj m94 ,syrup ( wild lettuce #abj m94 ,t9ct4 ( cocillana #dj m94 ,fluidextract ( squill #fj m94 ,fluidextract ( s5ega #fj m94 ,antimony & potassium t>tate #a gr4 ,casc>91 ,p4 ,d4 ,co4 #h grs4 ,m5?ol #h_/ajj gr4 ,to use a slang expression1 ?is is c]ta9ly go+ "s6--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,m>* #ah1 #aiaa47 8,a ,c\gh ,syrup ) a ,hi/ory0 ,! foll[+ lett] 0 receiv$ f ,dr4 ,geo4 ,p4 ,tolman1 ,watsonville1 ,cal43 ,to ! ,editor3--,! enclos$ adv]tisem5t 0 und]scor$ & mail$ to me by my druggi/4 ,! prop]ties ( cocillana are simil> to ipecac4 ,! dose ( ! fluidextract is f #aj to #bj m9ims4 ,ea* fluid\nce ( ! extraord9>y 767 d>k-color$ c\gh m>vel ( ,p4 ,d4 ,co4 conta9s #dj m9ims ( ! t9cture4 ,if ! t9cture ( cocillana is #aj p] c5t4 7! av]age t9cture /r5g?7 y c see t to get a m9imal dose ( ! drug y w\ld h to take #b-a_/b fluid\nces ( ! syrup4 8,qu]y3 ,c we /ill hang on to ! old-fa%ion$ c\gh mixtures fre%ly comp\nd$ by our druggi/s or %all we put our %\ld]s to ! :eel & help ,p4 ,d4 ,co4 save ! nation & make a few doll>s = ! druggi/80 8,! secret ( its prompt recognition lay 9 its unusual composition40 ,nay2 its prompt recognition lay 9 lib]al & p]si/5t adv]tis+4 8,x quickly made a #8hit' ) physicians0--because too _m physicians1 l o!r human be+s1 are susceptible to ! psy*ology ( adv]tis+4 ,"h is ! 8unusual composition10 z giv5 by ! manufactur]s3 8,t9ct4 ,euphorbia pilulif]a1 #abj m9s42 ,syrup ,wild ,lettuce1 #abj m9s42 ,t9ct4 ,cocillana1 #dj m9s42 ,syrup ,squill ,comp\nd1 #bd m9s42 ,casc>9 7,p4 ,d4 ,co471 #h grs42 ,h]o9 hydro*loride1 #h-bd gr42 ,m5?ol1 #h-ajj gr40 ,! foll[+ is a reproduction ( ! adv]tisem5t ref]r$ to3 ,illu/ration3 ---------------------------------------- -------------------- ,a c\gh syrup ) a hi/ory4 ,syrup ,cocillana ,comp\nd e/abli%$ itself ) ! m$ical pr(ession 9 a s+le season4 ,x 0 introduc$ 9 #aijf4 ,! secret ( its prompt recognition lay 9 its unusual composition4 ,! =mula %[$ a r>e comb9ation ( a/r+5ts & s$atives4 ,x quickly made a 8hit0 ) physicians4 ,! "n 8,syrup ,cocillana ,comp\nd0 soon began to appe> on prescriptions4 ,today ?is ag5t is ! mo/ widely prescrib$ ( all prep>ations = c\gh4 ,syrup ,cocillana ,comp\nd is a pr(itable product = ! druggi/ to sell4 ,x comm&s a good price4 ,be+ totally unlike ! common1 ord9>y d>k-color$ 8c\gh mixtures0 x does n ent] into competition ) !m4 ,be prep>$ to disp5se x4 ,suppli$ 9 p9t1 #e-p9t & gallon bottles4 ,home ,(fices & ,laboratories1 ,,p>ke1 ,,davis ,,co4 ,detroit1 ,mi*igan4 ---------------------------------------- -------------------- ,z we h said above1 ,p>ke1 ,davis ,co4 %\ld be pr\d ( ?is 8elegant specialty40 ,x w\ld be h>d to f9d a bett] specim5 ( a %otgun prescription2 n only does ! prescription conta9 eight +r$i5ts1 b "o ( ^! +r$i5ts 7comp\nd syrup ( squill7 itself conta9s ?ree4 ,z our correspond5t correctly /ates1 ! drug f :i* ! "n 7n ! action7 ( ! prep>ation is d]iv$ comes f ,bolivia & has prop]ties simil>--b evid5tly inf]ior--to ipecac4 ,t x possesses b little !rapeutic value is p]haps be/ evid5c$ by ! fact t1 9 spite ( ! propag&a made = x by ,p>ke1 ,davis ,co41 nei!r ! drug nor any prep>ation ( x is li/$1 s f> z we "k1 by any o!r l>ge ph>maceutical h\se1 ) "o exception4 ,besides cocillana ! prep>ation conta9s two o!r obsolete drugs1 wild lettuce & euphorbia pilulif]a4 ,! activity ( ! 8c\gh syrup10 x is ne$less to say1 dep5ds 9 ! ma9 on ! drug :i* is m or less buri$ 9 ! publi%$ =mula3 h]o9 hydro*lorid4 ,at "o "t ,p>ke1 ,davis ,co4 admitt$ t ! prep>ation ow$ its *ief value to h]o94 ,9 a lett] to ! ,c\ncil on ,ph>macy & ,*emi/ry ! firm said3 8,! physiologic action ( ?is syrup is t :i* w\ld be sugge/$ by ! con/itu5ts4 ,because ( its activity ! mo/ prom95t action w\ld be t *>act]i/ic ( h]o9 hydro*lorid40 ,)\t d\bt ! important +r$i5t1 f ! po9t ( view ( !rapeutic pot5cy1 is ! h]o92 & x is ?is drug d\btless1 t makes ! mixture a good 8repeat]40 ,syrup ,cocillana ,comp\nd is a no/rum sail+ "u false colors4 ,:e!r its cont9u$ use is due to its my/]i\s1 mean+less1 mislead+ "n or m]ely to insi/5t & p]si/5t adv]tis+ me?ods ( ,p>ke1 ,davis ,co4 is a "q4 ,nei!r explanation is any cr$it to ! m$ical pr(ession :i* tol]ates x1 or to ! physician :o prescribes x4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,feb4 #ae1 #aiac47 ,,aub]gi]',s ,,syrup ,,( ,,lactuc>ium ,t clause 9 ! ,f$]al ,food & ,drugs ,act :i* requires c]ta9 pot5t drugs to be decl>$ on ! label ( ! propriet>y mixtures conta9+ !m has be5 responsible = cle>+ up _m my/]ies4 ,physicians h frequ5tly wond]$ :y !y 7 unable to obta9 f ! syrup ( lactuc>ium1 ,u4 ,s4 ,p41 ! !rapeutic results :i* !y 7 able to obta9 f a propriet>y product kn[n z ,aub]gi]'s ,syrup ( ,lactuc>ium1 sold by ,f\g]a ,co4 at an exorbitant price & put up 9 8pat5t-m$ic9e0 /yle4 ,! milk-juice ( lettuce once bore ! reputation ( be+ a soporific--a reputation t has be5 artificially ma9ta9$ l>gely ?r\gh ! effects ( ! ,aub]gi] prep>ation4 ,) ! adv5t ( ! ,food & ,drugs ,act ! secret ( ! soporific effect ( ! ,aub]gi] product 0 expla9$--x conta9s morph94#abd #abd ,te*nically1 ?is is incorrect1 z ! company _h inconspicu\sly /at$ 9 ! 8lit]ature0--n on ! label--t ! prep>ation conta9$ 8extract ( opium40 ,! practical difficulties ( mak+ a satisfactory syrup ( lactuc>ium are n realiz$ by mo/ physicians4 ,to su* ! foll[+ note1 pres5t$ at a meet+ ( ! ,p5nsylvania ,ph>maceutical ,association by ,mr4 ,l\is ,emanuel1 presid5t ( ! ,p5nsylvania ,ph>macy ,bo>d1 w prove enlight5+3 8,did y ev] make a syrup ( lactuc>ium direct f ! crude drug8 ,if y did1 %ake h&s1 & let me hail y z a bro!r1 a bro!r ph>maci/ 9 fact wor?y ( ! title4 ,if y did n1 ,i am sorry = y2 y h miss$ some?+ wor? kn[+4 8,! ,am]ican ,j\rnal ( ,ph>macy tells u t 9 #ahea #8,aub]gi] cultivat$ lactuca & poppy on a l>g] scale1 9 ord] to obta9 lactuc>ium & opium4 ,please note ! latt] = fur!r ref]5ce4 ,9 lactuc>ium he f\nd lactuc91 mannite1 res91 c]91 asp>mid1 br[n color+-sub/ance & oxalic acid4' ,9 #ahfj1 9 ! same publication1 ,proctor says3 #8,! att5tion ( ! m$ical practition]s has ( late be5 turn$ to ! syrup ( lactuc>ium1 & ! prep>ation sold usually by apo!c>ies 9 ?is city is t kn[n z ,aub]gi]'s1 a ,fr5* prep>ation1 made by dissolv+ #cj p>ts ( alcoholic extract ( lactuc>ium 9 #ejj p>ts ( boil+ wat]1 /ra9+ ! liquor & add+ #ae1jjj p>ts ( boil+ simple syrup1 :i* is kept boil+1 & album9\s wat] add$ f "t to "t until x is cl>ifi$4' ,9 '#ff1 '#gg1 '#gh1 '#hb & '#hd v>i\s writ]s produc$ elaborate diss]tations on ! suppos$ improv$ me?ods ( mak+ ?is syrup1 b n "o has _h ! tem]ity ( inquir+ into ! !rapeutic value ( ?is prep>ation1 or to exam9e ! ,fr5* prep>ation to asc]ta9 :5ce comes its vaunt$ sup]iority4 8,! ,fr5*1 x is said1 are an impressionable p1 b !y appe> to h a limit2 !y d n take any *ances on pla9 syrup ( lactuc>ium4 ,!irs conta9s ! add$ product1 extract ( opium4 ,?is implies a lack ( fai? 9 soporific prop]ties ( lactuc>ium1 & displays a recklessness 9 reg>d to co/ & labor4 8,! ,national ,disp5satory1 fif? edition1 says3 8,! utility ( reta9+ lactuc>ium z an (ficial m$ic9e is v d\btful4 ,x may possibly be desirable z a hypnotic = v impressionable p]sons1 ) :om fai? 9 a rem$y supplies its want ( intr9sic effici5cy40 8,! (ficial modus op]&i = mak+ ?is syrup looks labori\s1 b ! innoc5t-look+ task ( r$uc+ ! drug to a co>se p[d] is a revelation to ! un9itiat$4 8,x 0 a hot day 9 ,july & x took my #age-p\nd cl]k & me all t day to r$uce #ej gm4 ( lactuc>ium to a satisfactory condition4 ,! /uff look$ l old pieces ( disc>d$ rubb] %oes1 & x really appe>$ to act l rubb]4 ,aft] p]spir+ all day ) ! ,ph>macopeia & iron mort>1 imag9e our disgu/1 if y c1 on read+ 9 ! ,national ,disp5satory ! foll[+3 8,?is alcoholic prep>ation ( lactuc>ium is q z valueless & m objectionable ?an ! syrup ( ! same drug40 8,moral3 ,:y pay #f4ej a p\nd = mat]ial t has no m$ic9al value1 & is s h>d to manipulate z lactuc>ium :5 decrepit rubb] %oes are s *eap8 ,y c h j z mu* fun on a hot summ] day 9 r$uc+ ! latt] to a co>se p[d] ) clean s& 9 an iron mort> z y c ) ! m exp5sive mat]ial40 ,"o ( ! advantages claim$ = ready-made prescriptions ov] ! made-to-ord] v>iety1 or ev5 ov] ph>macopeial prep>ations1 is t !y are m elegant 9 appe>ance & less (f5sive to ! no/rils & palate4 ,?is is ! common exp]i5ce ( physicians :o1 hav+ prescrib$ "s ready-made mixture1 wi% to *ange ! dose ( "o ( its con/itu5ts & write a prescription or ask _! ph>maci/s to prep>e a simil> prep>ation4 ,! inability ( ! ph>maci/ to prep>e a prep>ation ev5 approa*+ ! orig9al 9 appe>ance1 color or ta/e usually leads to increas$ confid5ce 9 ! skill ( ! manufactur] ( ! propriet>y & a correspond+ly decreas$ belief 9 ! ph>maci/'s pr(essional atta9m5ts4 ,b ^! conclusions1 al?\gh natural1 are bas$ on false premises4 ,z ! propriet>y did n h ! composition decl>$ on ! label1 a mixture bas$ on ! =mula diff]$ m or less widely f ! propriet>y x 0 expect$ to resemble4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #i1 #aiab47 ,a ,prote/ & a ,reply ,?ree mon?s aft] publi%+ ! =ego+ we receiv$ a n9e-page communication f ,com> ,co4 ( ,p>is1 ! promotors ( ,aub]gi]'s ,syrup ( ,lactuc>ium1 9 :i* !y took issue ) "s ( ! /atem5ts 9 our article4 ,! company claim$ t a possible reason = ! difficulty exp]i5c$ by ,mr4 ,l\is ,emmanuel 9 try+ to make ! ,syrup ( ,lactuc>ium f ! crude drug is t he did n use ! same v>iety ( ,lactuc>ium t x employs4 ,fur!rmore1 x said t ! pres5ce ( morph9 9 ! product 0 ackn[l$g$ be=e ! passage ( ! ,food & ,drugs ,act4 ,on m c>eful inve/igation1 we f9d t ?is is true--t ! pres5ce ( 8a c]ta9 proportion ( extract ( opium0 9 ! prep>ation 0 m5tion$ ev5 be=e ! f$]al ,food & ,drugs ,act compell$ ! morph9 cont5t to be publi%$ on ! label4 ,te*nically1 !n1 ,! ,j\rnal 0 incorrect 9 mak+ ! implication t ! m$ical pr(ession 0 n appris$ ( ! fact t ,aub]gi]'s ,syrup ( ,lactuc>ium conta9$ morph92 practically x 0 "r4 ,! in=mation t ,com> ,co4 gave to physicians 0 buri$ 9 its adv]tis+ 8lit]ature0 s t x is fair to assume t n "o physician 9 t5 ?\s& knew--previ\s to ! ,food & ,drugs ,act--t ,aub]gi]'s ,syrup ( ,lactuc>ium conta9$ morph94--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #i1 #aiab47 ,,t>t>li?9e ,t>t>li?9e 0 exam9$ by two *emi/s ^: reports indicate t x is an eff]vesc+ prep>ation compos$ approximately ( #bj p] c5t4 ( c>bonate ( li?ium & ab\t #hj p] c5t4 ( t>t>ic acid4 ,?us x is simply ano!r ( ! hundr$s ( li?ia prep>ations on ! m>ket (f]$ = ! cure ( rheumatism4 ,?is 9 spite ( ! fact t sci5tific inve/igation & cl9ical exp]i5ce h demon/rat$ t li?ia is ( v little use 9 ! treatm5t ( t disease4 ,:ile ! adv]tisem5t c>ries ! idea t ,t>t>li?9e is a product ( ! ,t>t>li?9e ,company1 & t ,mc,kesson & ,robb9s are simply sell+ ag5ts1 we are in=m$ t ! bus9ess is own$ by ,mc,kesson & ,robb9s1 :o "u ?is /yle manufacture a rem$y = rheumatism4--7,ab/ract$ f ,! ,j\rnal ,a4 ,m4 ,a41 ,april #bc1 #aijg47 ,,?oxos ,?oxos is a 8specialty0 ( ,john ,wye? & ,bro!r4 ,f an adv]tis+ circul> we le>n t x 8(f]s to ! physician a rational treatm5t = ,rheumatism1 bo? ! ,subacute & ,*ronic =ms1 ,li!mia1 ,rheumatic ,ar?ritis1 ,g\t1 ,sciatica & ! v>i\s manife/ations ( uric dia!sis10 & t 8x is a palatable solution ( ,/rontium & ,li?ium soluble salts1 ?irty-two gra9s1 comb9$ ) tw5ty-f\r m9ims ,w9e ( ,col*icum ,se$ & a vegetable alt]ative1 9 ea* fluid\nce1 flavor$ ) aromatics40 ,?is 8=mula0 does n indicate ! acid ) :i* ! metals /rontium & li?ium are comb9$1 or :at ! 8vegetable alt]ative0 is2 x is ess5tially a secret prep>ation4 ,to le>n :at ! miss+ & presumably active +r$i5ts are an analysis 0 made by our *emi/s4 ,,laboratory ,,report ,"o orig9al bottle ( ,?oxos1 ,john ,wye? & ,bro!r1 ,philadelphia1 0 pur*as$ & submitt$ to analysis4 ,! bottle conta9$ a br[n liquid hav+ an aromatic odor & a sweet ta/e4 ,! specific gravity ( ! liquid 0 #a4aah at #ae ,c4 7#fj ,f47 ,! solution 0 acid to litmus4 ,qualitatively ! foll[+ con/itu5ts 7 detect$3 /rontium1 potassium1 sodium1 li?ium1 ammonium1 salicylate1 iodid1 glyc]91 alkaloid1 alcohol & wat]4 ,by ! smell & ta/e1 oil ( w9t]gre51 or me?yl salicylate1 & oil ( sassafras 7 recogniz$4 ,positive te/s = a sapon9-l body indicat$ ! probable pres5ce ( s>sap>illa4 ,quantitatively ! foll[+ results 7 obta9$3 ,ammonia 7,,nh#c7 #j4jjf p] c5t4 ,li?ium 7,li7 #j4ac p] c5t4 ,sodium 7,na7 #j4jc p] c5t4 ,/rontium 7,sr47 #a4jc p] c5t4 ,iodid 7,i7 #j4df p] c5t4 ,salicylate 7,c#f;,h#d4,,oh4,,coo7 #d4ai p] c5t4 ,glyc]9 #ai4b p] c5t4 ,f ! analytic results x w\ld appe> t ! prep>ation conta9s approximately potassium iodid1 #j4fg gm4 p] hundr$ c4c41 or #c gra9s p] fluid\nce2 li?ium salicylate ,li7,c#g;,h#e,o#c71 #j4i gm4 p] hundr$ c4c41 or #d gra9s p] fluid\nce2 /rontium salicylate ,sr7,c#g;,h#e,o#c7b-b;,h#b,o1 #e4ge gm4 p] hundr$ c4c41 or #bf gra9s p] fluid\nce1 & "s salicylic acid comb9$ ) sodium & also 9 ! free /ate4 ,! total salicylate f\nd is equal to #e4dg gm4 ( sodium salicylate p] hundr$ c4c41 or #be gra9s p] fluid\nce4 ,z /rontium salicylate & li?ium salicylate are n[ g5]ally consid]$ to diff] b slightly1 if at all1 9 _! action f t ( sodium salicylate1 ea* dose ( ,?oxos1 #a teaspoonful or #d c4c41 may be consid]$ ! equival5t ( #j4b gm4 or #c gra9s ( sodium salicylate ) a fractional dose ( col*icum4 ,h5ce ?is no/rum--= ?is is ! correct def9ition--is a mixture ( no m value ?an a prescription ( sodium salicylate ) a fractional dose ( potassium iodid & col*icum1 "o t any doctor c\ld write & any druggi/ disp5se4 ,yet x is d\btless prescrib$ by physicians "u ! belief t x possesses "s occult p[] n to be f\nd 9 ord9>y drugs & _! comb9ations4 ,to prescribe ,?oxos is to prescribe a "n1 & ! pati5t :o takes x w\ld be z well (f if he w5t to ! ne>e/ drug /ore & pur*as$ a bottle ( any ( ! ?\s& & "o rheumatism cures ) :i* ! c\ntry is flood$4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,m>* #ba1 #aiad47 ,,trypsog5 ,besides exploit+ a clay p\ltice--8,anti!rmol9e0--! ,g4 ,w4 ,c>nrick ,company appe>s to be *iefly conc]n$ 9 ! promotion ( 8int]nal secretion0 specialties2 a class ( prep>ations ! !rapeutic value ( :i* is problematical4 ,?us x m>kets ! diabetes rem$y1 8,trypsog50 tablets1 said to conta9 8! enzyme ( ! isl&s ( ,lang]hans ) ! tryptic & amylolytic f]m5ts ( ! pancreas0 along ) gold bromid & ars5ic bromid2 ,secretog5 ,elixir1 said to be 8prep>$ f ga/ric secret9 obta9$ f ! pyloric antrum & pancreatic secret9 f ! duod5um1 comb9$ ) ! enzymes ( ! peptic gl&s1 & "o-tw5tie? ( "o p] c5t4 ,h,cl02 ,secretog5 ,tablets1 said to be 8prep>$ f prosecret9 & succus ent]icus obta9$ f ! epi!lial cells ( ! duod5um1 comb9$ ) pancreatic extract02 ,k9azyme1 8a prep>ation ( extract ( sple51 re9=c$ ) tryps91 amylops9 & calcium lactate40 ,:ile great claims h be5 made = ,trypsog5 & :ile x has be5 mo/ widely adv]tis$1 x is ! cons5sus ( op9ion ( ! mo/ em95t /ud5ts ( ! "q t pancreas is n really efficaci\s 9 diabetes4 ,7 x ( any value 9 ?is disease1 x w\ld h won _w-wide recognition = itself ere n[1 9 view ( ! great en?usiasm ) :i* ! discov]y ( ! relation ( ! pancreas to diabetes 0 receiv$ & ( ! enorm\s am\nt ( cl9ical1 z well z animal1 exp]im5tation t foll[$4 ,z ! conditions ( exp]im5t 9 ?is "q are extremely complex1 x is n surpris+ t occasionally app>5tly positive results %\ld h be5 obta9$4 ,7 x really useful1 x %\ld h yield$ positive results mu* m uni=mly4 ,fur!rmore1 if pancreas 7 really efficaci\s 9 ! treatm5t ( diabetes mellitus1 ! addition ( ars5ic1 ( gold1 ( bromid w\ld be entirely unnecess>y4 ,ev5 7 x grant$ t pancreas extracts are valuable 9 ! treatm5t ( diabetes1 & t gold & ars5ic also h b5eficial effects1 x is our op9ion t ,trypsog5 %\ld be consid]$ an unsci5tific %otgun mixture1 because fix$ comb9ations ( rem$ies ( diff]5t pot5cies1 su* z ars5ic1 gold1 bromid & pancreas1 are !rapeutically errone\s1 z !y d n p]mit ( t accurate adju/m5t ( dosage ( ea* +r$i5t t is indisp5sable to obta9 maximum b5efit ) m9imum dang] ( poison+4 ,anti!rmol9e & ,trypsog5 7 at "o "t describ$ 9 ,new & ,non(ficial ,rem$ies4 ,^! prep>ations 7 omitt$ :5 ! ,c\ncil's rules 7 revis$ "s ye>s ago4 ,:5 ! ,c\ncil 0 fir/ organiz$ x und]took only ! correction ( ! mo/ s]i\s abuses t _h become a "p ( ! propriet>y m$ic9e bus9ess1 & paid less att5tion to ! !rapeutic wor? ( a rem$y2 ?us at t "t x admitt$ bo? ,anti!rmol9e & ,trypsog5 to ,new & ,non(ficial ,rem$ies4 ,s9ce !n ! ,c\ncil has modifi$ its rules to exclude unsci5tific mixtures m>ket$ "u names t are mislead+ or !rapeutically sugge/ive4 ,accord+ly x resc9d$ ! acceptance ( ,anti!rmol9e1 :i* 0 ess5tially ! (ficial clay p\ltice1 ,cataplasma ,kaol9i1 ,u4 ,s4 ,p4 ,= simil> reasons & because ! !rapeutic claims 7 held unw>rant$ ,trypsog5 has be5 omitt$ f ,new & ,non(ficial ,rem$ies4 ,x is to be regrett$ t ! progress ( rese>* %\ld be h9d]$ & ! value ( g5u9e products ( int]nal secretion be depreciat$ by confusion ) su* %otgun mixtures & ass]t$ rem$ies1 ^: claims h receiv$ no sci5tific confirmation4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #a1 #aiac47 ,,tyree',s ,,antiseptic ,,p[d],,bf ,n[ ,adv]tis$ ,direct to ! ,public z ! 8,be/ ,prev5tative ,kn[n0 ,,bf ,see also report1 p4 #ba4 ,:5 ! hi/ory ( ! 8pat5t m$ic9e0 bus9ess comes to be writt5 imp>tially & fairly1 x w be realiz$ t we1 ! m$ical pr(ession1 h be5 9 no small degree responsible = its gr[?4 ,n a few widely adv]tis$ no/rums owe _! comm]cial success solely to ! ill consid]$ use accord$ !m by physicians1 to :om !y 7 fir/ exploit$4 ,z a well-kn[n & brilliant adv]tis+ man once said3 8,! pat5t m$ic9e ( ! future is "o t w be adv]tis$ only to doctors4 ,"s ( ! mo/ pr(itable rem$ies ( ! pres5t "t are ( ?is class4 ,!y are call$ propriet>y rem$ies4 ,! g5]al public nev] he>s ( !m ?r\gh ! daily press4 ,all _! publicity is secur$ ?r\gh ! m$ical press1 by means ( ! manufactur]'s lit]ature1 sometimes gott5 out 9 ! %ape ( a m$ical j\rnal1 & ?r\gh samples to doctors4444 ,! m$ical pap]s w reap ! h>ve/ & ! physician himself1 always s l\d 9 ! d5unciation ( #8pat5t m$ic9es1' w be ! mo/ important m$ium ( adv]tis+ at ! comm& ( ! propriet>y manufactur]4 ,9 fact1 he is t to-day40 ,illu/ration3 ,adv]tisem5t f a newspap]--,tyree's ,p[d] z a 8,pat5t ,m$ic9e0 ( ! 8,prev5tive0 ,type4 ,( ! conditions "h describ$ probably no bett] example c be f\nd ?an ,tyree's ,antiseptic ,p[d]4 ,= ye>s ?is prep>ation 0 adv]tis$ to ! m$ical pr(ession "u claims t 7 fraudul5t z to bo? composition & !rapeutic effect4 ,analysis publi%$ 9 ,! ,j\rnal#abe prov$ t ! =mula giv5 out by ,tyree 0 absolutely false & t ! prep>ation 01 ess5tially1 no?+ b a simple mixture ( sulphate ( z9c & boric acid4 #abe ,oct4 #bj1 #aijf1 & ,may #ah1 #aijg4 ,f ! fir/ x w\ld seem t ! manufactur]s ( ?is mixture _h = _! objective po9t t p]iod :51 ?anks to ! use ( ! no/rum by physicians1 x w\ld be widely pur*as$ by ! public4 ,lavi% adv]tis+ 0 done 9 m$ical j\rnals & ,tyree's ,antiseptic ,p[d] ga9$ admission to ! pages ( ev5 ^? j\rnals :i* requir$ ! publication ( a 8=mula0--= a =mula 0 =?com+4 ,! ,j\rnal itself1 until sev5 ye>s ago1 c>ri$ ! adv]tisem5ts ) a 8=mula0 until *emical exam9ation prov$ ! falsity ( ! =mula1 & ( ! !rapeutic claims made = ! product4 ,! m$ical pr(ession 9 its turn prescrib$ ! no/rum & ! 8orig9al package0 s*eme did ! re/4 ,illu/ration3 ,adv]tisem5t f ,m$ical ,j\rnal--,tyree's ,p[d] z a ,highly ,respectable 8,e?ical ,propriet>y40 ,n[1 x seems1 ,tyree consid]s 8 prep>ation s well kn[n t he c be indep5d5t ei!r ( ! assi/ance ( ! physician or ( 8 good-w4 ,= ,tyree's p[d] n[ goes to ! public direct & newspap] read]s f9d x adv]tis$ z3 8,ideal = d\*e40 8,unequall$ z a d\*e40 8,be/ prev5tative kn[n40 8,unequall$ z a prev5tative40 8,has no equal z a prev5tative40 ,& ! foll[+1 ^: v tru? mu/ br+ ! blu% ( %ame to all physicians :o h ! int]e/ ( sci5tific m$ic9e at he>t3 8,prescrib$ by physicians all ov] ! _w = tw5ty-"o ye>s40 8,ask y\r doctor or s5d = booklet40 8,us$ by doctors = ! la/ tw5ty-"o ye>s40 8,"o ( ! highe/ tributes paid ,tyree's ,antiseptic ,p[d] is ! fact t ! mo/ successful physicians h be5 us+ x = ! la/ tw5ty-"o ye>s40 ,n t ,tyree has entirely =sak5 ! m$ical j\rnals1 al?\gh he seems to be dropp+ !m "o by "o4 ,at ! beg9n+ ( ?is ye> at lea/ fifte5 m$ical j\rnals 7 c>ry+ ! ,tyree adv]tisem5t2 by ,m>* ! numb] _h fall5 to sev51 :ile 9 ,june ! only j\rnals c>ry+ x 73 ,m$ical ,record ,am]ican ,j\rnal ( ,ob/etrics ,*icago ,m$ical ,record] ,pacific ,m$ical ,j\rnal ,^? :o answ] ! newspap] adv]tisem5ts receive a free sample ( ! p[d] & sev]al leaflets & circul>s giv+ ! v>i\s uses 787 ( ! no/rum4 ,incid5tally ^! leaflets adv]tise1 9 addition1 ,tyree's 8,elixir ,bu*u & ,hyoscyamus ,comp410 :i* is recomm5d$1 9 v>i\s comb9ations1 = su* conditions z acute nephritis1 epilepsy1 neura/h5ia1 gonorrhea & delirium trem5s4 ,be>+ 9 m9d ! claim t is made 9 ! newspap] adv]tisem5ts t ,tyree's ,antiseptic ,p[d] is ! 8be/ prev5tative0 kn[n1 x is int]e/+ to see :at ,tyree has to say to ^? druggi/s :om he (f]s to supply ) circul>s = free di/ribution3 8,z ^! circul>s deal ) ! c>e ( rubb] goods1 = bo? m$ic9al & toilet purposes1 !y are ( great value to ! cu/om] & w be reta9$ = fur!r ref]5ce4 ,!y are boo/]s = y\r rubb] goods sales1 too40 ,t a no/rum ( ?is sort %\ld g to ! public is n surpris+1 b t x %\ld h rea*$ ! public ?r\gh ! in/rum5tality ( ! m$ical pr(ession is a s]i\s reflection on ! judgm5t ( physicians4 ,b ! incid5t has a bright side4 ,t ! exploit]s ( ?is no/rum no long] f9d x pr(itable to use m$ical j\rnals z a means ( gett+ _! /uff to ! public b mu/ ne$s use ! m exp5sive newspap] adv]tis+1 is cause = optimism4 ,x means t physicians are no long] prescrib+1 indiscrim9ately1 propriet>y products & t !y are refus+ to be1 :at !y h be5 9 ! pa/1 ! unpaid di/ribut+ ag5ts = no/rum v5d]s4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,aug4 #bd1 #aiab47 ,,vapo-,,cresol5e ,vapo-,cresol5e has be5 exam9$ 9 ! ,am]ican ,m$ical ,association's laboratory & ! *emi/s' report foll[s3 ,accord+ to ! /atem5ts on ! trade package1 ,vapo-,cresol5e 8is a product ( coal-t> possess+ f> great] p[] ?an c>bolic acid 9 de/roy+ g]ms ( disease40 ,x is recomm5d$ z a rem$y = a numb] ( diseases1 includ+ cr\p1 cat>rh & diph!ria4 ,accord+ to ! manufactur]s1 x %\ld be us$ only 9 8! ,cresol5e vaporiz]10 :i* makes x 8unequal$ = ! dis9fection ( sick rooms0 & ! 8safe/ & simple/ me?od ( de/roy+ infection & purify+ ! air40 ,f ! exam9ation we conclude t ,vapo-,cresol5e is ess5tially cresol & corresponds 9 e respect to cresol ,u4 ,s4 ,p4 7,physician's ,manual1 page #cf74 ,?is report indicates t ,vapo-,cresol5e is a memb] ( t class ( propriet>ies 9 :i* an ord9>y product is end[$1 by ! manufactur]1 ) extraord9>y virtues4 ,! type is s common & has be5 ref]r$ to s frequ5tly t b = ! dang]s att5dant on ! inhalation ( any ( ! ph5ols1 ?is p>ticul> product ne$ n h be5 m5tion$4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,april #d1 #aijh47 ,,vasog5 ,,& ,,iodovasog5 ,ano!r ,case 9 ,:i* ,indep5d5t ,analyses & ,manufactur]s' ,labels ,disagree ,vasog51 a product ( ,pe>son ,company1 ,hamburg1 ,g]many1 has be5 put on ! m>ket "u ! v>i\s designations1 8oxyg5at$ vasel9e10 8wat]-soluble hydroc>bon0 & 8oxyg5at$ c>bon40 ,! manufactur]s1 & also _! ,am]ican ag5ts1 ,lehn ,f9k1 claim t by a special process ! app>5t impossibility ( saponify+ petrolatum has be5 ov]come ) ,vasog5 z ! result4 ,dis9t]e/$ *emi/s :o h analyz$ ,vasog5 f9d t ! product consi/s ess5tially ( an ammonium soap & petrolatum--practically an ammonia l9im5t mix$ ) petrolatum4 ,j z petrolatum "u its v>i\s trade names 0 at "o "t recomm5d$ z a univ]sal o9tm5t base1 s vasog5 is recomm5d$ promiscu\sly z a vehicle = rem$ies appli$ ext]nally & ev5 = int]nal m$ication--ne$less to say 9 _m cases 9 :i* x is directly contra-indicat$4 ,iodovasog51 recomm5d$ = ext]nal application z a sub/itute = t9cture ( iod91 0 exam9$ by ,z]nik 9 #aije1 :o f\nd t ! iod9 exi/$ n z a free iod91 b *iefly z ammonium iodid4 ,! !rapeutic "* ( ! prep>ation is ?us entirely diff]5t f t to be inf]r$ f ! labels & else:]e1 s9ce ! c\nt]-irritant effects ( free iod9 are ( c\rse abs5t 9 ammonium iodid4 ,pe>son ,co4 n[ claim t :5 ,z]nik's f9d+s 7 publi%$ !y imm$iately modifi$ _! /atem5ts on ! label 9 accordance ) ! tru?4 ,?is is d5i$ by ,dr4 ,lungwitz1 ! editor ( ! ,!rapeutis*e ,runds*au 7,apo!k] ,zeitung1 #aijh1 p4 #ijj71 :o vigor\sly criticizes ! misrepres5tation made by ,pe>son ,co4 9 reg>d to ,iodovasog54 ,he calls att5tion to ! fact t1 :ile ,z]nick's results 7 publi%$ ov] ?ree ye>s ago1 ! labels :i* are 9 use today /ill be> ! /atem5t t ,iodovasog5 consi/s ( ,vasog5 #ij p>ts & resublim$ iod9 #aj p>ts1 & ,vasog5 #id p>ts & resublim$ iod9 #f p>ts1 respectively4 ,z ,iodovasog5 & ,vasog5 9 v>i\s comb9ations are be+ adv]tis$ to ! physicians 9 ! ,unit$ ,/ates1 ! above in=mation f our ,g]man ex*anges is wor?y ( consid]ation4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,feb4 #ac1 #aiji47 ,,viburnum ,,comp\nd--,,& ,,o!r ,,no/rums ,a numb] ( drugs h "s reputation = !rapeutic value )\t !re be+ any p>ticul> evid5ce to sub/antiate ! claims4 ,viburnum1 conc]n+ :i* we rec5tly receiv$ ! foll[+ lett]1 is "o ( ^! drugs3 ,to ! ,editor3--,h y made an analysis ( ,viburnum ,comp\nd8 ,extravagant claims are be+ made = x & ,i _c put my h& on any data4 ,a pati5t has ask$ me conc]n+ x & ,i wi% to advise h] hone/ly4 ,i d n "k b t !re may be sev]al 8viburnum comp\nds40 ,i r>ely use any ( ^! 8put-up0 prep>ations1 & h5ce "k b little ab\t !m4 ,a4 ,j4 ,hess]1 ,m4,d41 ,pittsburgh1 ,pa4 ,no analysis ( ,hayd5's ,viburnum ,comp\nd1 to :i* our correspond5t ref]s1 has be5 made 9 ! ,association laboratory4 ,accord+ to adv]tis+ circul>s1 ! prep>ation conta9s ,am]ican skullcap 7,scutell>ia lat]iflora71 cramp-b>k 7,viburnum opulus7 & wild yam 7,dioscorea villosa74 ,s9ce ^! drugs conta9 no well-def9$ !rapeutically active +r$i5ts1 an analysis ( ! prep>ation w\ld necess>ily be unsatisfactory4 ,a numb] ( drugs h 9 "s way obta9$ a reputation z be+ valuable 9 ! treatm5t ( diseases ( wom51 )\t _! !rapeutic claims ev] hav+ be5 prov$4 ,x is said t "s 7 us$ by ! aborig9es = su* affections & we f9d a consid]able numb] ( !m comb9$ 9 v>i\s no/rums 7sometimes ) !rapeutically active drugs7 & exploit$ = ! cure ( female disord]s1 "u mo/ extravagant & usually absurd claims4 ,?us 8,pi]ce's ,favorite ,prescription0 is adv]tis$ z conta9+ black coho%1 blue coho%1 gold5seal1 lady's-slipp] & false unicorn-root2 8,dioviburnia0 7,dios ,*emical ,co47 z conta9+ ,am]ican skullcap1 cramp-b>k1 wild yam1 blue coho%1 black haw1 />-grass1 trail+ arbutus & false unicorn-root2 8,viburnumal0 7,l\isville ,ph>macal ,works7 z conta9+ ,am]ican skullcap1 cramp-b>k1 wild yam1 />-grass & mo!rwort4 ,mo/ ph>maceutical h\ses1 foll[+ ! lead ( no/rum-mak]s1 put simil> mixtures on ! m>ket2 = example3 8,elixir ( ,viburnum ,comp\nd0 7,nelson1 ,bak] ,co47 is said to conta9 cramp-b>k1 ,am]ican skullcap & wild yam2 8,elixir ( ,hydra/is & ,viburnum ,comp\nd0 7,smi?1 ,kl9e ,fr5* ,co471 cramp-b>k1 gold5seal1 ,jamaica dogwood & pulsatilla2 8,elixir ( ,hydra/is & ,cramp ,b>k ,comp\nd0 7,p>ke1 ,davis ,co471 cramp-b>k1 hydra/is1 ,jamaica dogwood & pulsatilla2 8,fluid ,extract ( ,cramp ,b>k ,comp\nd0 7,h4 ,k4 ,mul=d ,co471 ,am]ican skullcap1 cramp-b>k & wild yam2 8,"m's ,cordial0 7,eli ,lilly ,co471 cramp-b>k1 blue coho%1 false unicorn & squaw v9e2 8,ut]9e ,s$ative ,elixir0 7,eli ,lilly ,co471 cramp-b>k1 gold5seal1 ,jamaica dogwood & pulsatilla2 8,vibut]o0 7,fr$4 ,/e>ns ,co471 cramp-b>k1 wild yam1 black haw1 squaw v9e1 ,jamaica dogwood1 saw palmetto & pulsatilla4 ,practically all ( ^! drugs except gold5seal are ignor$ 9 ! /&>d works on ph>macology4 ,fur!r1 ! results ( c>eful exam9ation by ! ,c\ncil on ,ph>macy & ,*emi/ry ( ! !rapeutic claims made = mo/ ( !m %[s t ^! claims are n su/a9$ by reliable cl9ical exp]i5ce4 ,! fact is t ! popul>ity ( prep>ations ( ?is k9d is purely an artificially creat$ "o4 ,a no/rum conta9+1 let u say1 extractives ( "s little-us$ or wor?less drugs is put on ! m>ket & heavily adv]tis$4 ,%\ld x be adv]tis$ 9 a mann] to make x sell1 a ho/ ( imitations appe> & ! l>ge ph>maceutical h\ses put out sub/itutes = x4 ,! uncritical physician does ! re/4 ,he prescribes x indiscrim9ately 9 ! class ( cases = :i* x is adv]tis$4 ,naturally1 a c]ta9 proportion ( ! pati5ts :o take x recov]1 & ! recov]ies are cr$it$ to ! no/rum4 ,a vici\s circle is ?us e/abli%$ & ! dem& = ! /uff increases4 ,its sale1 toge!r ) ! sale ( simil> products1 cont9ues until ! ov]:elm+ exp]i5ce ( ^? :o h prescrib$ x proves its uselessness4 ,9 ! meantime ! manufactur]s h reap$ a h>ve/1 at ! exp5se bo? ( ! public & ( ! m$ical pr(ession4 ,& ! manufactur]s' excuse = putt+ su* absurd 8specialties0 on ! m>ket is t physicians prescribe !m6--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,aug4 #ca1 #aiab47 ,,:eel]',s ,,n]ve ,,vitaliz] ,names ( no/rums (t5 mislead by ! use ( fake nom5clature giv+ errone\s ideas reg>d+ ! composition ( ! prep>ation or misrepres5t+ ! true action ( ! no/rum4 ,z an example ( ! latt] class ,:eel]'s ,n]ve ,vitaliz] 0 exam9$ 9 ! ,association laboratory & f\nd to be n a vitaliz]1 z ! "n implies1 b r a n]ve s$ative4 ,! results ( ! exam9ation foll[3 ,:eel]'s ,n]ve ,vitaliz] 0 pack$ 9 a c>ton be>+ ! "n ( ! prep>ation1 its manufactur]s1 8,! ,j4 ,w4 ,brant ,co41 ,ltd41 ,albion1 ,mi*410 & an exhau/ive li/ ( ! diseases = :i* ! product is int5d$1 besides ! g5]al /atem5t t x is a cure = 8all n]v\s diseases40 ,! 8,vitaliz]0 is a br[n1 syrupy liquid hav+ a peculi> salty ta/e p>tially mask$ by licorice4 ,qualitative te/s %[$ ! pres5ce ( sodium1 potassium & brom91 & no o!r acid radicals except small quantities ( *lor94 ,x 0 decid$ !re=e t ! prep>ation conta9$ a mixture ( sodium & potassium bromids4 ,9 ord] to sep>ate ! *lor9 & brom9 ! prep>ation 0 evaporat$1 *>r$1 extract$ ) wat] & acetic acid & potassium p]manganate add$ & ! mixture di/ill$ ) /eam until all ! brom9 _h be5 di/ill$ ov]1 ?us leav+ ! *lor9 9 ! di/ill+ flask4 ,! solution 9 ! di/ill+ flask 0 !n treat$ ) silv] nitrate & ! *lor9 e/imat$ 9 ! usual way4 ,! quantity ?us obta9$ 0 subtract$ f ! total silv] bromid & *lor9 obta9$ by precipitat+ a solution ( ! prep>ation ) silv] nitrate & ! rema9d] calculat$ to brom94 ,by ?is me?od sev]al samples ( #e c4c4 ea* ( ! prep>ation yield$ an av]age ( #j4jjei cm4 silv] *lorid or #j4jjab gm4 p] c4c4 ,! total silv] haloids obta9$ by direct precipitation ( ! dilut$ prep>ation 0 f\nd to be #j4caeh gm4 p] c4c41 ?us leav+ #j4cadf gm4 silv] bromid to be calculat$ to brom94 ,! total sodium & potassium 0 obta9$ 9 ! usual way & ! potassium det]m9$ z ! *lor-plat9ate & ! sodium calculat$ f ! diff]5ce4 ,by ?is me?od ! quantity ( sodium f\nd calculat$ to sodium bromid gave ! foll[+ results3 7a7 #j4jfbi gm4 & 7b7 #j4jfcb gm41 or an av]age ( #j4jfc gm4 p] c4c4 ,f ! potassium e/imations ! foll[+ 7 calculat$3 7a7 #j4abfd gm4 potassium bromid & 7b7 #j4abei gm4 potassium bromid p] c4c41 an av]age ( #j4abfa gm4 potassium bromid p] c4c4 ,! bromids calculat$ f ! sodium & potassium det]m9ations 7 f\nd to be #j4jfcj gm4 sodium bromid & #j4abfa gm4 potassium bromid p] c4c41 ! equival5t ( #j4caci gm4 silv] bromid4 ,! total silv] bromid obta9$ 0 #j4cadf gm41 %[+ practical agreem5t ) ! total bromids calculat$ f ! sodium & potassium det]m9ations4 ,! prep>ation conta9$ !n #f4cj gm4 sodium bromid & #ab4fa gm4 potassium bromid p] #ajj c4c41 or #i4gc gra9s ( potassium bromid & #d4hf gra9s sodium bromid1 a bromid cont5t equal to #ae4ce gra9s potassium bromid p] fluid dram4 ,,zymotoid ,a ,fraud ( ! ,liquozone-,oxytonic-,septicide ,type ,dr4 ,arnold's ,zymotoid1 a no/rum manufactur$ by ,arnold's ,zymotoid ,company1 ,rock=d1 ,ill41 is claim$ to be an 8antiseptic1 g]micide & antiphlogi/ic0 :i* 8has absolutely no pe] 9 m$ic9e40 ,accord+ to ! /atem5ts ( ! manufactur]1 ,zymotoid is 8successfully employ$ n only z an ext]nal dress+ on all w\nd$ & diseas$ surfaces1 b 9 all zymotic conditions :]e9 a reliable antiseptic & g]micide is ne$$ int]nally40 ,& 9 tell+ physicians ( ! great value ( ,zymotoid ! company says3 8,we assur$ !m t if !y w\ld simply place ,zymotoid #8next' to any w\nd$ surface--& no?+ else--!y w\ld h no inflammation1 no suppuration1 no infection or blood poison4 ,its prompt use 9 all cases :]e su* tr\ble arises gives imm$iate & c]ta9 relief40 ,?is is a l>ge contract to be und]tak5 by ,zymotoid--or any o!r prep>ation--:i*1 z w be %[n1 consi/s pr9cipally ( boric acid & wat]4 ,! company also app5ds to its ann\ncem5t conc]n+ ,zymotoid a numb] ( ! usual te/imonials & a lot ( alleg$ 8case reports40 ,zymotoid seems to be exploit$ pr9cipally by circul>s address$ to physicians & by ag5ts :o attempt to sell x to physicians4 ,!y also try to "w factories & o!r l>ge employ]s ( labor4 ,9 _! circul> to physicians !y claim t 8,zymotoid is /rictly e?ical40 ,& 8we publi% its composition40 ,! composition giv5 is3 8sulphur1 nit]1 c9namon & boric acid 9 gase\s solution40 ,x is also claim$ to be 8a *emical comp\nd--n a mixture--:i* is :olly non-toxic & c be us$ z freely z desir$ int]nally absolutely )\t h>m to ! smalle/ *ild40 ,on ! label ( ! ,zymotoid package is ! foll[+3 8,zymotoid is a conc5trat$ *emical comp\nd consi/+ ( ! solids & gases ( sulphur1 potassium nitrate1 c9namon & c>bon held 9 a solution ( boric acid40 ,a specim5 ( ,zymotoid 0 exam9$ by our *emi/s & _! report foll[s4 ,z w be se51 x is simply ano!r fraud ( ! ,liquozone-,oxytonic-,septicide type4 ,,laboratory ,,report ,,on ,,zymotoid ,zymotoid is a pale yell[ liquid hav+ a /rong odor l sulphur dioxid4 ,no odor sugge/ive ( c9namon 0 obs]v$ ev5 aft] ! sulphur dioxid _h be5 fix$ by ! addition ( an alkali4 ,qualitative te/s indicat$ ! pres5ce ( boric acid1 sulphuric acid1 sulphur dioxid & traces ea*1 ( a nitrate1 potassium & "s unid5tifi$ organic matt]4 ,alkaloids1 c9namic acid1 glyc]9 & soaps 7 abs5t4 ,f ! results ( ! quantitative exam9ation x is conclud$ t ! composition ( ,zymotoid is ess5tially z foll[s3#abf #abf ,details ( ! analysis appe> 9 ! annual reports ( ! ,*emical ,laboratory4 ,boric acid 7,h#c;,,bo#c7 #j4fcg gm4 ,sulphur dioxid 7,,s#b7 #j4abi gm4 ,sulphuric acid 7,h#b,,s#d7 #j4jdh gm4 ,potassium nitrate trace ,unid5tifi$ organic matt] trace ,wat] 7by diff]5ce7 to make #ajj c4c4 ,! analysis %[s t b = ! pres5ce ( boric acid ! composition ( ,zymotoid is simil> to o!r fraudul5t 8microbe kill]s0 :i* h be5 exploit$ 9 rec5t ye>s & ( :i* "s h be5 decl>$ misbr&$ by ! f$]al gov]nm5t4 ,= example1 8,radam's ,microbe ,kill]0#abg 0 f\nd by ! f$]al *emi/s to be compos$ ( wat]1 conta9+ small quantities ( sulphur dioxid & sulphuric acid4 8,liquozone10 ano!r no/rum :i* 0 widely exploit$ a few ye>s ago1 is said to h a simil> composition4#abh ,accord+ to an analysis made at ! ,nor? ,dakota ,agricultural ,exp]im5t ,/ation1#abi 8,oxytonic0 has a simil> composition4 ,! no/rum 8,septicide10 0 f\nd by ! f$]al *emi/s to be compos$ ( wat] ) small quantities ( sulphur dioxid1 sulphuric acid & a trace ( a nitrate4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,april #f1 #aiab47 #abg ,! ,j\rnal ,a4 ,m4 ,a41 ,july #af1 #aiaj1 p4 #bce4 #abh ,! ,j\rnal ,a4 ,m4 ,a41 ,m>* #bh1 #aijh1 p4 #ajfe4 #abi ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #a1 #aiaj1 p4 #fc4 ,,"p ,,iv ,,contributions ,,f ,,! ,,j\rnal3 ,,miscellane\s ,,matt] ,,acetph5etid9 ,,& ,,ph5acet9--,,_! ,,relative ,,purity ,until six ye>s ago ! *emical product kn[n z ph5acet9 0 pat5t$ bo? z to process & to product4 ,z ! pat5t ran out at t "t1 anyone1 ( c\rse1 c\ld manufacture x4 ,x 0 plac$ 9 ! ,ph>macopeia "u ! "n 8acetph5etid940 ,x is on ! m>ket n[ "u bo? names1 8ph5acet90 & 8acetph5etid940 ,! price ( ! =m] is five times#acj t ( ! latt]1 h5ce x is r important to "k :e!r or n "o is1 9 any way1 bett] or pur] ?an ! o!r4 ,! orig9al pat5tees or manufactur]s1 ! ,f>b5fabrik5 ( ,elb]feld ,company1 m>ket ! product "u ! "n 8ph5acet90 & also "u ! (ficial "n 8acetph5etid910 ! =m] at ab\t #cc c5ts an ounce & ! latt] at ab\t #f or #g c5ts an ounce4 ,evid5tly ^! p believe t acetph5etid9 is all "r s9ce _! price-li/ says3 8,our product is ( ! highe/ /&>d ( purity10 & 9 ano!r place3 8,on acc\nt ( ! l[ price ( acetph5etid9um1 ,u4 ,s4 ,p41 x is especially suitable = ! manufacture ( m$ic9al specialties1 su* z heada*e p[d]s1 etc40 ,rememb] t x is ! manufactur]s ( ph5acet9 :o say ?is4 #acj ,ph5acet9 is li/$ at #cc c5ts an ounce1 acetph5etid9 at #ih c5ts a p\nd 9 qu>t]-p\nd lots4 ,! "q arose :e!r or n ph5acet9 diff]s f acetph5etid94 ,if x does1 !n physicians %\ld "k x4 ,an inquiry 0 address$ to ,f>b5fabrik5 ( ,elb]feld ,company & also to ,lehn ,f9k1 two firms :i* m>ket ! product 9 ?is c\ntry "u bo? names1 ask+ 9 :at respect ! two products diff]4 ,no answ] 0 receiv$ f ei!r firm4 ,) ! object ( answ]+ ! "q our *emi/s h inve/igat$ ! prep>ations on ! m>ket1 bo? ^? sold "u ! "n 8ph5acet90 & ^? "u ! (ficial title 8acetph5etid940 ,! foll[+ is a summ>y ( _! report3#aca #aca ,full details ( analysis are publi%$ 9 ,volume ,v ( ! annual report ( ! ,*emical ,laboratory4 ,,! ,,*emi/s' ,,report ,physical ,appe>ance4--,all ! specim5s 7 f\nd to be f9e :ite cry/all9e p[d]s1 diff]+ some:at 9 appe>ance z foll[s3 ,f\r specim5s--,acetph5etid9 7,f>b5fabrik571 ,ph5acet9 7,specim5 #aacb--;,f>b5fabrik571 ,ph5acet9 7,specim5 #bacb--;,f>b5fabrik57 & ,acetph5etid9 7,squibb7--appe>$ v mu* alike1 ea* be+ a v f9e cry/all9e p[d]1 diff]+ only slightly z to f95ess4 ,five o!r specim5s--,ph5acet9 7,lehn ,f9k71 ,acetph5etid91 ,u4 ,s4 ,p4 7,lehn ,f9k71 ,acetph5etid9 7,m]ck71 & two specim5s ( ,acetph5etid9 7,p[]s-,weightman-,ros5g>t571 _h ! same g5]al appe>ance1 ea* consi/+ ( a f9e cry/all9e p[d] conta9+ a consid]able proportion ( l>ge rectangul> plates4 ,?ree specim5s--,acetph5etid9 7,mall9ckrodt7 & two specim5s ( ,acetph5etid9 7,p[]s-,weightman-,ros5g>t57--_h ! same g5]al appe>ance1 be+ a mod]ately f9e & homog5e\s cry/all9e p[d]4 ,:5 exam9$ microscopically ) a l[-p[] l5s ! ,mall9ckrodt product appe>$ to consi/ pr9cipally ( rectangul> prisms & ! ,p[]s-,weightman-,ros5g>t5 product to be made up l>gely ( plates4 #acb 8,specim5 #a0 is a specim5 ( ! product regul>ly sold 9 ?is c\ntry4 8,specim5 #b0 is a specim5 ( a product sold 9 ,engl& & ^: resale 9 ?is c\ntry 0 prohibit$ by ! manufactur]s4 ,id5tity4--,all ( ! specim5s :5 te/$ side by side respond$ to & compli$ ) ! id5tity te/s ( ! ,unit$ ,/ates1 ,briti%1 ,g]man1 ,swiss1 ,dut*1 ,sw$i%1 ,spani%1 & ,dani% ph>macopeias4 ,! reactions giv5 by ! sev]al specim5s 7 all ! same1 %[+ no diff]5ce 9 any case4 ,melt+-,po9ts4--,z a fur!r pro( ( id5tity & simil>ity ! melt+-po9ts ( ! diff]5t specim5s 7 tak5 & f\nd to be3 ,acetph5etid9 7,f>b5fabrik571 #acd4b ,c42 ,ph5acet9 7,specim5 #a--;,f>b5fabrik57 #acc4g ,c42 ,ph5acet9 7,lehn ,f9k71 #acd4g ,c42 ,acetph5etid9 7,lehn ,f9k7 #acd4i ,c42 ,acetph5etid9 7,p[]s-,weightman-,ros5g>t571 7#a7 #acd4c ,c41 7#b7 #acc4f ,c41 7#c7 #acd4g ,c41 7#d7 #acd4g ,c42 ,acetph5etid9 7,squibb7 #acd4b ,c42 ,acetph5etid9 7,m]ck71 #acd4h ,c41 & ,acetph5etid9 7,mall9ckrodt71 #acd4b ,c4 ,! melt+-po9t is giv5 z #ace ,c4 9 ! ,briti%1 ,fr5* & ,spani% ph>macopeias1 & z #acd to #ace ,c4 9 ! ,unit$ ,/ates1 ,g]man1 ,swiss1 ,dani%1 ,sw$i% & ,dut* ph>macopeias4 ,?us all comply ) ! /&>d giv5 9 our ph>macopeia & mo/ =eign ph>macopeias ) two exceptions & ^? respectively only #j4c ,c4 & #j4d ,c4 l[4 ,abs5ce ( ,acetanilid4--,! abs5ce ( acetanilid 9 all ! specim5s 0 indicat$ by ! brom9 te/ ( ! ,unit$ ,/ates1 ,briti%1 ,g]man1 ,swiss1 ,dut*1 ,sw$i% & ,dani% ph>macopeias4 ,abs5ce ( ,c>bonizable ,matt]4--,! abs5ce ( c>bonizable matt] 0 %[n 9 all specim5s by ! sulphuric acid te/ ( ! ,unit$ ,/ates1 ,briti%1 ,g]man1 ,fr5*1 ,swiss1 ,dut*1 ,sw$i% & ,spani% ph>macopeias4 ,wat]-,soluble ,matt]4--,all specim5s :5 te/$ = excess ( wat]-soluble matt] came well )9 ! limit 7#j4ej p] c5t47 set by ! ,fr5* ph>macopeia1 ! greate/ am\nt be+ #j4bj p] c5t4 ,a%4--,:5 heat$1 all ! specim5s 7 f\nd to yield practically no a%1 ! residues f #a gm4 samples weigh+ 9 no case m ?an #j4jjjd gm4 ,abs5ce ( ,p>aph5etid94--,:5 te/$ by ! me?ods ( ! ,unit$ ,/ates1 ,briti%1 ,g]man & ,fr5* ph>macopeias1 ! abs5ce ( an impurity ( p>aph5etid9 0 %[n 9 all specim5s1 ) ! exception ( "o specim5 obta9$ f ,p[]s-,weightman-,ros5g>t5 ,co41 :i* gave a positive1 ?\gh n /rong1 reaction & two o!r specim5s ( ! same firm :i* react$ /ill m fa9tly4 ,,table ,,%[+ ,,results ,,( ,,analyses ,,( ,,v>i\s ,,specim5s ,,( ,,acetph5etid9 ,,& ,,ph5acet9,,bg ,,column ,,head+s3 ,a ,melt+ ,po9t 7,corr47 ,c4 ,b ,wat]-,soluble ,matt] 91 p] ,c5t4 ,c ,a%1 p] ,c5t4 ,d ,p>aph5etid91 ,u4 ,s4 ,p4 ,te/,,bh ,e ,p>aph5etid91 ,swiss ,te/,,bh ,physical ,"n ,appe>ance ,a ,b ,c ,d ,e ---------------------------------------- ---------------------- ,acetph5etid9 ,v f9e #acd4b #j4ag #j4jb - 7,f>b5fabrik57 homog5e\s 7#a7 cry/all9e p[d] ,ph5acet9 ,v f9e #acc4g #j4jf #j4jj - 7,f>b5fa- homog5e\s brik57 cry/all9e p[d] ,ph5acet9 ,f9e cry/all9e #acd4g #j4aa #j4jb - 7,lehn ,f9k7 p[d]1 n uni=m ,acetph5etid9 ,f9e cry/all9e #acd4h #j4ac #j4jj - 7,lehn ,f9k7 p[d]1 n uni=m ,acetph5etid9 ,homog5e\s #acd4c #j4ai #j4jc 7,p4 ,w4 ,r47 7#a7 cry/all9e p[d] ,acetph5etid9 ,homog5e\s #acd4g #j4af #j4jb 7,p4 ,w4 ,r47 7#b7 cry/all9e p[d] ,acetph5etid9 ,homog5e\s #acd4g #j4ad #j4jb 7,p4 ,w4 ,r47 7#c7 cry/all9e p[d] ,acetph5etid9 ,f9e cry/all9e #acc4f #j4bj #j4ja - - 7,p4 ,w4 ,r47 7#d7 p[d] ,acetph5etid9 ,f9e cry/all9e #acd4c #j4ai #j4jj - 7,squibb7 p[d] ,acetph5etid9 ,f9e cry/all9e #acd4h #j4ae #j4jc - - 7,m]ck7 p[d] ,acetph5etid9 ,f9e cry/all9e #acd4b #j4aa #j4ja - - 7,mall9ckrodt7 p[d] ---------------------------------------- ---------------------- ,,bg ,9 all cases id5tity 0 confirm$2 acetanilid 0 abs5t2 c>bonizable matt] 0 abs5t4 ,,bh ,9 ?is column plus indicates pres5ce2 m9us1 abs5ce4 ,:ile ?is firm's product alone gave any reaction :atev] :5 ! ,u4 ,s4 ,p4 te/ = p>aph5etid9 0 appli$ ) ! te/ ( ! ,swiss ph>macopeia1 all b ,acetph5etid9 7,mall9ckrodt71 ,acetph5etid9 7,m]ck7 & "o specim5 ( ,p[]s-,weightman-,ros5g>t5 ,co4 gave positive1 ?\gh v fa9t1 reactions1 indicat+ t ! majority ( specim5s1 includ+ ^? ( ! orig9al manufactur]1 conta9 a m9ute trace ( ?is impurity4 ,our f9d+s reg>d+ ! product ( ,p[]s-,weightman-,ros5g>t5 ,co4 hav+ be5 communicat$ to ?is firm1 _! correctness 0 ackn[l$g$4 ,at ! same "t ! firm wrote3 8,all t we h on h& n[ gives negative te/s = p>aph5etid91 & we believe our pres5t records are correct :5 we /ate t all lots :i* we are supply+ n[1 & h be5 supply+ = "s "t pa/1 answ] all ,u4 ,s4 ,p4 requirem5ts40 ,?is exam9ation appe>s to demon/rate t ! *emical sub/ance1 p>a-acetph5etid91 :e!r sold z acetph5etid91 ,u4 ,s4 ,p41 or z ph5acet91 is practically id5tical4 ,! impurity ( ! product ( "s ( ! specim5s com+ f ,p[]s-,weightman-,ros5g>t5 ,co4 is too slight to be consid]$ dang]\s4 ,fur!rmore1 a comp>ison ( ! 8lot numb]s0 indicates t ?is firm has be5 improv+ its product /eadily s t 9 ! future its assurances ( an unimpea*able product may be reli$ on4 ,inasmu*1 !re=e1 z acetph5etid9 complies ) all ! ph>macopeial requirem5ts z to id5tity & purity1 9 j ! same way z ph5acet91 :i* sells = z high z five times ! price ( acetph5etid91 physicians ne$ n hesitate 9 us+ ! title ( ! ,u4 ,s4 ,p4 8acetph5etid90 :5 prescrib+ ?is produce4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,m>* #af1 #aiab47 ,acetph5etid9 & ,ph5acet9 ,a physician-ph>maci/ writes3 8,if a prescription calls = #8ph5acet91' %\ld ! ph>maci/ disp5se #8ph5acet9-,bay]'--t is1 ! ph5acet9 manufactur$ by ! orig9al pat5tee--or w\ld he be ju/ifi$ 9 disp5s+ ! (ficial acetph5etid91 manufactur$ by any reliable *emical or ph>maceutical h\se80 ,unless ! ph>maci/ happ5s to "k t ! physician 9 writ+ ! prescription desir$ ! ,bay] br&1 he w\ld be ju/ifi$ 9 disp5s+ acetph5etid91 ,u4 ,s4 ,p4 ,z a g5]al ?+1 physicians use ! ^w 8ph5acet90 )\t int5d+ to prescribe any p>ticul> br& or make1 simply because !y are famili> ) ?is ^w & are n famili> ) ! (ficial t]m 8acetph5etid940 ,!y w d\btless cont9ue to use ! t]m 8ph5acet90 & we "k ( no suffici5t reason = do+ o!rwise4 ,dur+ ! life ( ! pat5t ! ^w 8ph5acet90 became a famili> "o1 & ! product became g5]ally kn[n by ?is t]m4 ,b a co9$ "n = a pat5t$ article loses its propriet>y "* & becomes ! common "n ( ! article :5 ! pat5t expires4 ,9 o!r words1 :5 ! pat5t expires1 n only ! product b also ! "n itself becomes common prop]ty4 ,?is pr9ciple has be5 recogniz$ by ! c\rts4 ,^? :o =m]ly controll$ ! product & ! "n 8ph5acet90 evid5tly recogniz$ ?is pr9ciple1 = !y h tak5 no /eps to prosecute a firm 9 ?is c\ntry :i* sells ! product op5ly "u ! "n 8ph5acet940 ,x might be add$ t ! prep>ation is (ficial 9 mo/ =eign ph>macopeias "u ! "n 8ph5acet940 ,9 agreem5t also ) ?is pr9ciple ! ,c\ncil on ,ph>macy & ,*emi/ry 7,! ,j\rnal1 ,april #bg1 p4 #abih7 li/s 9 ,new & ,non(ficial ,rem$ies su* products z 8lanol910 8ph5acet910 8sulphonal0 & 8trional0 z non-propriet>y names appli$ to ,adeps lan hydrosus1 ,u4 ,s4 ,p41 ,acetph5etid9um1 ,u4 ,s4 ,p41 ,sulphonme?anum1 ,u4 ,s4 ,p41 & ,sulphone?ylme?anum1 ,u4 ,s4 ,p41 respectively4 ,9 view ( ^! facts--& also be>+ 9 m9d ! f9d+s ( ! ,association's ,*emical ,laboratory 7,! ,j\rnal1 ,m>* #af1 p4 #hja7 t ! prep>ations on ! m>ket "u ! title 8acetph5etid90 are ( equal quality ) ! prep>ations sold "u ! "n 8ph5acet90--! ph>maci/ %\ld recognize t acetph5etid9 is id5tical ) ph5acet91 is prescrib$1 provid$1 ( c\rse1 t no special br& ( ph5acet9 is ord]$4 ,x is ! physician's privilege1 ( c\rse1 to specify ! goods ( a p>ticul> manufactur]1 b 9 view ( ! fact br\ght out above t all br&s ( ?is *emical h te/$ up to ! ,u4 ,s4 ,p4 /&>d1 x is plac+ an unnecess>y burd5 on ! ph>maci/ to require him to h on h& _m diff]5t br&s ( "o sub/ance4 ,! physician %\ld save ?is privilege = use :5 prescrib+ "s product t diff]s mat]ially 9 its v>i\s =ms on ! m>ket1 z = example 9 ! case ( c]ta9 fluidextracts4 ,physicians w d\btless f9d t ! above comm5ts w int]e/ _! local ph>maci/s4 ,x is ( mutual value = physicians to talk ^! matt]s ov] ) _! ph>maci/s4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,oct4 #e1 #aiab74 ,,clean ,,adv]tis+ ,x is individual ef=t t c\nts = mo/ 9 e movem5t = bett] ?+s--socially1 economically or politically4 ,realiz+ ?is1 ,! ,j\rnal repeat$ly urges physicians :o write reg>d+ v>i\s fraudul5t adv]tisem5ts to ent] _! individual1 p]sonal prote/ aga9/ ! cont9uation ( su* adv]tisem5ts4 ,)9 ! pa/ few mon?s ,! ,j\rnal has _h br\ght to its att5tion a good example ( :at may be accompli%$ by p]sonal ef=t 9 clean+ up ! adv]tis+ pages ( a frat]nal publication4 ,! ,royal ,neighbor1 (ficial organ ( a frat]nal organization1 until comp>atively rec5tly1 c>ri$ num]\s fraudul5t m$ical adv]tisem5ts4 ,fake liquor cures1 rheumatism cures1 tapeworm expell]s1 tobacco-habit cures1 a/hma & hay-fev] cures1 epilepsy cures1 etc41 disgrac$ its adv]tis+ pages4 ,^! call$ =? prote/s f ,dr4 ,e4 ,a4 ,hall1 ,h5ry1 ,ill41 :o address$ lett]s to ! (ficial physicians ( ! frat]nal ord] t ! ,royal ,neighbor repres5ts1 object+ to su* adv]tisem5ts4 ,^! lett]s 9 turn rea*$ ! adv]tis+ manag]1 & x 0 n long be=e ! bo>d ( manag]s took ! matt] up = consid]ation & decid$ to elim9ate ?is class ( adv]tis+ f _! (ficial organ4 ,by ,decemb]1 #aiac1 ! ,royal ,neighbor came to its read]s clean4 ,!re is no d\bt t ! same results c be duplicat$ 9 simil> cases4 ,:e!r !y are w dep5d on ! am\nt ( active "w done by individuals int]e/$ 9 ! "q ( clean adv]tis+4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,feb4 #ad1 #aiad47 ,,lipp9cott',s ,,magaz9e ,its ,adv]tis+--a ,prote/ & an ,excuse ,a few days ago a physician wrote to ,! ,j\rnal enclos+ two adv]tisem5ts tak5 f ! curr5t issue ( ,lipp9cott's magaz9e4 ,"o ( ^! 0 a half-page adv]tisem5t ( t outrage\s fraud1 ! 8,oxydonor20 ! o!r 0 a full-page adv]tisem5t ( ,j4 ,b4 ,lipp9cott ,company1 ,philadelphia1 call+ = salesm5 8to pres5t /&>d m$ical books to physicians only40 ,! physician s5d+ 9 ?is mat]ial ask$ u to s5d to ,lipp9cott's a pamphlet %[+ ! fraudul5ce ( ! ,oxydonor4 ,in/ead ( do+ s1 we s5t ! pamphlet to ! physician & sugge/$ t he write a p]sonal lett] 9 ! belief t individual mission>y "w is ! mo/ effective way ( fight+ fraud4 ,accord+ly ! doctor wrote to ,lipp9cott's & receiv$ 9 reply ?is lett] f ! adv]tis+ dep>tm5t ( t publication3 8,y\r lett] ( ! #bc;d receiv$1 & 9 reply beg to say t we d n approve ( fraudul5t adv]tis+1 & we h nev] be=e be5 advis$ t ! adv]tisem5t to :i* y call our att5tion 0 objectionable4 ,9 fact1 we "k no?+ :atev] ab\t x4 ,italics ours4--,ed4 ,x came to u1 z d mo/ ( ! o!rs1 ?r\gh an adv]tis+ ag5cy1 & :ile we d n will+ly publi% any?+ t is fraudul5t or objectionable1 x is n our cu/om to v]ify ! claims ( adv]tis]s ,italics1 aga91 ours4--,ed4 especially :5 ! same copy is be+ run 9 almo/ e o!r high-grade publication4 8,we h a v high reg>d = ! ,am]ican ,m$ical ,association1 & !y und\bt$ly are do+ a spl5did "w 9 ridd+ ! c\ntry ( fake m$ical prep>ations1 b ! m]e fact t !y condemn "s ( our adv]tis]s is h>dly suffici5t pro( = u to refuse ! adv]tis+1 because1 if ! adv]tis] desires to d s1 he c make u prove 9 ! c\rts t he is a fak]1 or claim damages f u = refus+ to publi% 8 adv]tisem5t4 ,our italics4--,ed4 ,if ! ,am]ican ,m$ical ,association w gu>antee to protect ! publi%]s aga9/ loss f damage suits br\ght by adv]tis]s ^: bus9ess !y refuse to accept1 !n1 we believe t ! publi%]s w\ld gladly reject !m1 b n _m ( ! publi%]s are 9 a position to inve/igate ! m]its ( all ! adv]tis+ t is (f]$1 especially :5 ! claims are back$ up by affidavits ( reputable p :o believe !mselves to h be5 cur$ by ! prep>ation4 8,we c]ta9ly d n wi% to jeop>dize our m$ical publications by adv]tis+ fake s*emes or propositions ( any k9d1 & we ?ank y = writ+ u conc]n+ ! matt] & w n[ look into ?is p>ticul> case40 ,illu/ration3 ,photographic reproduction 7mu* r$uc$7 ( two adv]tisem5ts f ,janu>y1 #aiad1 ,lipp9cott's4 ,"o ( a fraudul5t quasi-m$ical device1 ! 8,oxydonor02 ! o!r1 call+ = salesm5 to introduce 8/&>d m$ical books to physicians40 ,?is lett] discloses ! work+s ( ! bra9 ( an adv]tis+ man ( ! old s*ool4 ,! pr9ciples enunciat$ !re9 are ^? t dom9at$ ! adv]tis+ field until q rec5tly4 ,!y repres5t ! laissez faire doctr9e z appli$ to adv]tis+4 ,at t "t ! only unacceptable adv]tis+ copy 0 t :i* w\ld deb> ! publication us+ x f ! ,unit$ ,/ates mails4 ,?is 0 ! y>d/ick by :i* all adv]tis+ 0 measur$ at t "t4 ,! economic consci5ce has s9ce awak5$4 ,!re are few reputable magaz9es today1 we v5ture to believe1 t w\ld be will+ to g on record to ! effect t x is n _! 8cu/om to v]ify ! claims ( adv]tis]s40 ,! mod]n1 progressive adv]tis+ man recognizes n only ! responsibilities 8 pr(ession imposes1 b also realizes t1 f ! n>r[] view ( enlight5$ self-int]e/1 ! greate/ m5ace to ! future ( mod]n adv]tis+ is ! fraudul5t adv]tisem5t4 ,! claims on ! "p ( ! adv]tis+ dep>tm5t ( ,lipp9cott's t x d>es n refuse to accept fraudul5t adv]tisem5ts because ! adv]tis] might br+ suit aga9/ x = refus+ to accept 8 adv]tisem5t is a /atem5t ^: falsity is exce$$ only by its sill9ess4 ,equally prepo/]\s is ! /atem5t t ,lipp9cott's w will+ly refuse to accept fraudul5t adv]tisem5ts provid$ ! ,am]ican ,m$ical ,association w gu>antee to protect ! ,lipp9cott ,company aga9/ loss f damage suits t may be br\ght by ! exploit]s ( ! frauds ^: adv]tisem5ts are refus$4 ,x may be news to ,lipp9cott's to le>n t !re are a score & m ( newspap]s & magaz9es t are accept+ ! f9d+s ( ! ,am]ican ,m$ical ,association on m$ical frauds & reject+ adv]tisem5ts ( su* frauds4 ,!re are _m newspap]s t s5d u ! m$ical adv]tis+ 8copy0 submitt$ to !m & ask = an op9ion on x4 ,:5 t op9ion is unfavorable1 ^! pap]s refuse su* adv]tisem5ts4 ,?is is be+ done daily4 ,we h yet to he> ( any 8pat5t m$ic9e0 fak] or quack ev5 ?reat5+ to br+ suit because 8 adv]tisem5ts h be5 reject$4 ,! adv]tis+ dep>tm5t ( ,lipp9cott's may !re=e take he>t4 ,:5 an adv]tisem5t ( an outrage\s fake l ! ,oxydonor is submitt$ to x1 in/ead ( accept+ ! money = x1 meantime mutt]+ an inaudible prote/ at ! un=tunate position 9 :i* x has be5 plac$1 x may look ! fraud 9 ! eye & say ,boo6 ,! fak] w n bite4 ,be=e leav+ ! subject1 we are con/ra9$ to ref] to ,lipp9cott's m$ical publication1 ! ,annals ( ,surg]y4 ,we beg9 to realize n[ :y t j\rnal (f]s a welcome hav5 to su* products z ,sal ,hepatica1 ,bromidia1 ,pap9e1 ,gray's ,glyc]9 ,tonic1 ,fell[s' ,syrup ( ,hypophosphites1 et al4 ,presumably ! same 8cu/om0 obta9s 9 ! acceptance ( adv]tis+ = ! ,annals ( ,surg]y z = ,lipp9cott's1 namely t ! ,lipp9cott ,company does 8n v]ify ! claims ( adv]tis]s40 ,possibly ! ,annals ( ,surg]y is afraid t1 %\ld x reject ! ,sal ,hepatica adv]tisem5t1 = in/ance1 x might he hal$ into c\rt6 ,let u tru/1 = _! peace ( m9d1 t ! publi%]s ( ! ,annals ( ,surg]y d n receive an adv]tisem5t f ,old ,doc ,h>tman = a full page display ( ,p]una4 ,! m5tal angui% !y w\ld und]go 9 reluctantly accept+ ?is adv]tisem5t--"u ! fe> t ,h>tman w\ld 8claim damages0 if x 7 reject$--is pa9ful to contemplate4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,feb4 #g1 #aiad47 ,,m$ical ,,j\rnal ,,adv]tis+ ,& ,me?ods ( ,obta9+ ,paid-,up ,subscrib]s ,"t 0 :5 ! po/al au?orities 7 l5i5t ) publi%]s4 ,! names ( individuals :o _h ev] subscrib$ = publications ( a c]ta9 class 7 c>ri$ on ! books indef9itely1 :e!r !y paid _! subscriptions or n4 ,?is p]mitt$ a padd+ ( ! circulation figures4 ,( late ye>s1 h[ev]1 ! po/(fice dep>tm5t requires publi%]s to h bona-fide paid-up subscriptions if !y wi% _! publications to be c>ri$ at ! l[ second-class rate4 ,c]ta9 m$ical j\rnals h be5 h>d put to x to get a circulation t w\ld be at all attractive to ! adv]tis]s1 on ^: money !y dep5d = cont9u$ exi/5ce4 ,_m & v>i\s h be5 ! s*emes devis$ :]eby ! dw9dl$ circulation might be 8boo/$40 ,subscriptions c\ld n be giv5 away because ! po/al laws =bade x4 ,"o +5i\s me?od ( obviat+ ?is difficulty is work$ 9 ?is fa%ion3 ,dr4 ,john ,doe writes an article t appe>s 9 a reputable m$ical j\rnal4 ,a few days aft] its appe>ance1 ,dr4 ,doe receives a lett] f ! editor & publi%] ( a m$ical j\rnal t is 9 ne$ ( a subscription li/4 ,he is told t ! editor has read 8 article ) mu* int]e/ & w\ld appreciate receiv+ f ,dr4 ,doe a brief ab/ract ( x4 ,he does n expect ! doctor to g to ! tr\ble ( mak+ ?is ab/ract = no?+4 ,he w1 !re=e1 on receipt ( ! ab/ract cr$it ,dr4 ,doe ) ?ree ye>s' subscription = himself or = "o ye> = himself & "o ye> = ea* ( any o!r two doctors he may "n4 ,= e doctor t bites on ?is s*eme ! publi%] increases 8 circulation by ?ree copies & ! f$]al (ficials are assur$ t !y are paid-up subscriptions--n paid = 9 ca%1 x is true1 b 9 8ab/racts40 ,all ( ?is prelim9>y to a lett] rec5tly receiv$3 ,to ! ,editor3--,enclos$ f9d lett] :i* speaks = itself4 ,n[ :at ,i %\ld l to "k f y is ! foll[+3 ,is ! ,*>lotte ,m$ical ,j\rnal all x %\ld be8 ,%\ld a doctor contribute to a j\rnal--!reby add+ to its pre/ige & circulation--t c>ries que/ionable matt] 9 ! adv]tis+ pages8 ,if ! above j\rnal is (f color1 does t act z a b> = good m5 to contribute8 ,v truly y\rs1 ,l4 ,j4 ,g5ella1 ,m4,d41 ,new ,orleans1 ,la4 ,! lett] :i* our correspond5t encloses is on ! /ation]y ( ! ,*>lotte ,m$ical ,j\rnal & sign$ by ! editor ( t j\rnal4 ,"h x is3 8,my ,de> ,doctor ,g5ella3--,i h j look$ ov] an article ( y\rs publi%$ 9 ! ,new ,orleans ,m$ical & ,surgical ,j\rnal entitl$ #8,cl9ical ,/udies 9 ,pituit>y ,irritation1 ) ,report ( ,case4' ,i w\ld be v glad inde$ to h y s5d me a manuscript or article = ! ,*>lotte ,m$ical ,j\rnal4 ,y\r /yle ( writ+ is v attractive4 8,if y w s5d me an article = ! j\rnal1 ,i w be glad to publi% same & w place y\r "n on my complim5t>y mail+ li/4 ,"u sep>ate cov] ,i am s5d+ y a copy ( ! j\rnal4 8,( c\rse ,i w expect ! article to be typewritt540 ,:e!r or n ?is is a modification ( ! 8ab/ract0 s*eme or an attempt to boo/ ! circulation ( ! ,*>lotte ,m$ical ,j\rnal are que/ions we %all n attempt to answ]4 ,z to ! que/ions prop\nd$ by our correspond5t1 !y h be5 answ]$ _m times 9 ^! pages4 ,we turn to "o ( ! rec5t copies ( ! ,*>lotte ,m$ical ,j\rnal & exam9e its adv]tis+ pages4 ,on "o ( ! fir/ we f9d ,anas>c91 a product ^: fraudul5t "* 0 describ$ at "s l5g? 9 ,! ,j\rnal1 ,may #d & #aa1 #aijg4 ,on ano!r page we f9d ,tongal9e1 :i* has also come 9 = a fair %>e ( att5tion 7see ,! ,j\rnal1 ,sept4 #bc1 #aijf1 & ,may #aj1 #aiac74 ,a little f>!r ov] we f9d a half-page adv]tisem5t ( ,bann]man's ,intrav5\s ,solution1 a no/rum fir/ exploit$ z a 8consumption cure0 & n[ z a cure-all 7see ,! ,j\rnal1 ,may #ca1 #aiac74 ,cact9a ,pillets 7see ,! ,j\rnal1 ,m>* #ab1 #aiaj71 ,hagee's ,cordial ( ! ,extract ( ,cod-,liv] ,oil 7see ,! ,j\rnal1 ,oct4 #ac1 #aijf71 ,burnham's ,soluble ,iod9 7see ,! ,j\rnal1 ,m>* #bh1 #aijh71 ,ec?ol 7see ,! ,j\rnal1 ,m>* #ac1 #aiji71 ,bromidia 7see ,! ,j\rnal1 ,april #ba1 #aijf71 ,pap9e 7see ,! ,j\rnal1 ,april #bi1 #aiaa71 ,ph5alg9e--two adv]tisem5ts 7see ,! ,j\rnal1 ,jan4 #ac1 & #bg1 #aijf1 & ,jan4 #bg1 #aiab7 & ,sal ,hepatica 7see ,! ,j\rnal1 ,m>* #bf1 #aiaj7 are "s m products :i* h atta9$ un5viable notoriety b f\nd a safe hav5 9 ! adv]tis+ pages ( ! ,*>lotte ,m$ical ,j\rnal4 ,nei!r mu/ we fail to ref] to ! adv]tisem5t ( ,duffy's ,malt ,:iskey 7see ,! ,j\rnal1 ,nov4 #bc1 #aiab71 :i* looks ?or\ghly at home4 ,does our correspond5t--9 fact1 does any consci5ti\s physician hav+ ! int]e/ ( sci5tific m$ic9e at he>t--want to d any?+ t w t5d to p]petuate !rapeutic fraud8 ,subscrib+ = or contribut+ to m$ical j\rnals ^: income is l>gely d]iv$ f no/rums t are z vici\s z _m ( ! 8pat5t m$ic9es0 adv]tis$ 9 ! daily press hamp]s ! m$ical pr(ession 9 its fight = hone/y 9 !rapeutics & r5d]s l>gely abortive its fight aga9/ fraudul5t 8pat5t m$ic9es40 ,s long z ! accr$it$ organs ( ! m$ical pr(ession tol]ate fraudul5t 8e?ical propriet>ies0 9 _! adv]tis+ pages1 j s long w ! prote/s ( physicians aga9/ ! sw9dl+ adv]tisem5ts ( 8pat5t m$ic9es0 9 ! daily press fall l>gely on deaf e>s--& ju/ly s4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,oct4 #aa1 #aiac47 ,a ,physician ,places ! ,responsibility = ,fraudul5t ,adv]tis+ ,:]e ,x ,belongs 8,to ! ,editor3--,! ,j\rnal has _h mu* to say 9 rec5t ye>s reg>d+ ! e?ics1 or lack ( same1 9 adv]tis+ matt] exploit$ by its contempor>ies4 ,x has be5 criticiz$ by _m = ! /r+5cy ( its attack2 x has be5 criticiz$ by v few because x did n g f> en\gh4 ,is x n ab\t "t to get to ! root ( ! matt]8 8,9 ! la/ numb] see p4 #dbf1 ?is book dissatisfaction is express$ ) ! adv]tis+ policy ( ! ,m$ical ,times4 ,no?+ f9]6 ,g to x6 ,b is ! me?od ( attack "r8 ,i h be=e me a sample copy ( ! ,am]ican ,j\rnal ( ,surg]y4 ,among o!r articles is "o on diseases ( jo9ts & ! bone m>r[ by a man v favorably kn[n 9 ,d5v]4 ,he 0 #8e?ical' en\gh to be accord$ a place on ! program 9 ! ,section on ,m$ic9e at ,m9neapolis4 ,ano!r contributor f ,baltimore rem>ks t he took a pati5t to ! ,univ]sity ,hospital4 ,c x be possible t ,johns ,hopk9s is admitt+ m5 to its w>ds & cl9ics t are bel[ p> 9 pr(essional morals8 ,ano!r article appe>s f a well-kn[n or?op$ic man ( ,wa%+ton1 ,d4 ,c4 ,p]sonally1 ,i see v little to comm5d 9 ! adv]tis+ columns ( ! ,am]ican ,j\rnal ( ,surg]y4 8,i1 :o confess to a /ate bord]+ on y\?1 may be v wrong2 b ,i believe t ! tr\ble w be solv$ only :5 m5 :o claim to h any pr(essional di/9ction refuse to contribute to j\rnals ^: pages are n clean f cov] to cov]4 ,p>don ! presumption1 ,mr4 ,editor1 b 7 y ev] tempt$ to pr9t any?+ l ?is3 8#8,la/ week's issue ( ! ,new ,york ,m$ical ,squall conta9s an article on 8,duod5al ,ulc]0 by ,john ,doe1 ! well-kn[n ,*icago surgeon4 ,dr4 ,doe d\btless kn[s z well z any "o ! disreputable "* ( ! ,squall's adv]tis+ matt]1 b l mo/ ( our great m51 is unable to re/ra9 8 appetite = j\rnali/ic publicity4' 8,physicians read m$ical j\rnals because !y conta9 lit]ature t is wor? :ile4 ,jump on y\r err+ editorial bre?r51 ,mr4 ,editor1 b please rememb] t ! problem ( elim9at+ bogus adv]tisem5ts w be solv$ :5 ! s-call$ lead]s ( our pr(ession %[ en\gh manhood to refuse lit]>y support to publications ^: columns are 9 disrepute4 ,:ile ca/igat+ ! little s9n]1 please don't let ! big s9n] g scot free4 8,cl9ton ,e4 ,h>ris1 ,m4,d41 ,gr9nell1 ,i[a40 ,dr4 ,h>ris sums up ! situation correctly4 ,no small degree ( responsibility re/s on ! prom95t memb]s ( ! m$ical pr(ession :o l5d _! support ei!r z subscrib]s = or contributors to ^? m$ical j\rnals ^: adv]tis+ pages are a /5* 9 ! no/rils ( ?9k+ physicians4 ,dr4 ,h>ris asks :y ,! ,j\rnal does n condemn ! adv]tis+ columns ( ! ,am]ican ,j\rnal ( ,surg]y4 ,! ,j\rnal has done s m ?an once & 9 no unc]ta9 t]ms1 bo? 9 ! ,propag&a dep>tm5t & editorially4 ,at "o "t x said3 8,9 circul> lett]s & 9 an editorial ann\ncem5t 9 its ,decemb] issue1 ! ,am]ican ,j\rnal ( ,surg]y #8features'--to use a newspap] t]m--"s ( ! contributors to its ,janu>y issue4 ,! li/ comprises m5 :o hold1 or h held1 high (fices 9 ! ,am]ican ,m$ical ,association4 ,presid5ts1 vice-presid5ts1 *airm51 secret>ies & memb]s ( sections ( ! ,association--^! are "s ( ! m5 ^: names appe> z contributors to ?is no/rum-promot+ publication4 ,is x any wond] t ! proprietors ( ! ,am]ican ,j\rnal ( ,surg]y assume an attitude ( indiff]5ce to ! class ( propriet>y prep>ations :i* !y admit to ! pages ( _! publication80 ,:at 0 ! result ( ,! ,j\rnal ?us direct+ ! att5tion ( its read]s to ! ,am]ican ,j\rnal ( ,surg]y8 ,9 ! next issue ( ! ,am]ican ,j\rnal ( ,surg]y appe>$ a sev5-column editorial tirade1 entitl$ 8,an ,unw>rant$ ,attack on ! ,presid5t & ,o!r ,em95t ,memb]s ( ! ,am]ican ,m$ical ,association & on ! ,lead+ ,m$ical ,j\rnals ( ! ,c\ntry40 ,on _m & v>i\s occasions has ,! ,j\rnal call$ att5tion to ! v evils t ,dr4 ,h>ris deplores1 & = ! b5efit ( ^? :o c>e to look up ! matt] ^! ref]5ces to "s ( ! articles are app5d$3 8,! ,mote & ! ,beam10 editorial1 ,nov4 #ah1 #aiaa4 8,activity or ,passivity--,sympa?y or ,sacrifice10 editorial1 ,dec4 #i1 #aiaa4 8,cui ,bono10 editorial1 ,dec4 #af1 #aiaa4 8,m$ical ,j\rnals & ! ,great ,am]ican ,fraud10 ,propag&a ,dep>tm5t1 ,dec4 #af1 #aiaa4 8,! ,pr(ession ,mu/ ,apply ! ,p5alty10 editorial1 ,jan4 #ac1 #aiab4 8,fraudul5t ,adv]tis+ 9 ,high-,class ,m$ical ,j\rnals10 editorial1 ,jan4 #d1 #aiac4 8,dem& ,clean ,adv]tis+10 editorial1 ,jan4 #d1 #aiac4 8,m$ical ,j\rnals & ! ,great ,am]ican ,fraud10 editorial1 ,jan4 #ah1 #aiac4 8,a ,good ,pr9ciple to ,apply10 editorial1 ,may #ac1 #aiac4 8,m$ical ,j\rnal ,adv]tis+10 ,propag&a ,dep>tm5t1 ,oct4 #aa1 #aiac4 8,m$ical ,j\rnals & ! ,great ,am]ican ,fraud10 ,propag&a ,dep>tm5t1 ,oct4 #ah1 #aiac4 8,m$ical ,j\rnals & ! ,great ,am]ican ,fraud10 ,propag&a ,dep>tm5t1 ,nov4 #a1 #aiac4 8,! ,m$ical ,times' ,adv]tisem5ts10 ,propag&a ,dep>tm5t1 ,nov4 #h1 #aiac4 ,9 ano!r lett] on ! same subject its writ] says3 8,i ?9k ! "t has arriv$ :5 we h a "r to expect real lead]%ip f ! #8big m5' ( ! pr(ession40--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #bb1 #aiac47 ,,m$ical ,,j\rnals ,,& ,,! ,,great ,,am]ican ,,fraud ,h[ ! ,m$ical ,times ,aids & ,abets ,quack]y1 ) ! ,moral ,support ( ,memb]s ( ! ,m$ical ,pr(ession ,two lett]s h be5 receiv$1 bo? f physicians4 ,"o comes f ,new ,york ,city & ! o!r f ,alex&ria1 ,va4 ,ea* lett] conta9$ an adv]tisem5t ( ! ,kellam ,hospital1 ,ri*mond1 ,va41 cut f ! ,m$ical ,times4 ,"h is ! ,new ,york lett]3 8,to ! ,editor3--,i am enclos+ an adv]tisem5t clipp$ f ! ,m$ical ,times4 ,x seem$ to me an especially flagrant example ( :at may happ5 9 ! abs5ce ( prop] sup]vision ( ! adv]tis+ pages ( a m$ical magaz9e4 ,! condition w\ld seem all ! worse 9 ?is in/ance z among ! #8,bo>d ( ,contribut+ ,editors' are li/$ m5 l ,h[>d ,lili5?al ( ,new ,york & ,almu? ,c4 ,v&iv]1 :o is ,c\nsel = ! ,m$ical ,society ( ! ,c\nty ( ,new ,york4 ,! ,m$ical ,times is s5t to two ( ! physicians :o live at ?is address )\t *>ge & )\t solicitation4 ,_m adv]tisem5ts ( propriet>y prep>ations are ins]t$ 9 type indi/+ui%able f t ( ! body ( ! magaz9e & x is ( c\rse possible t its f9ancial back+ comes entirely f ! manufactur]s ( ^! drugs40 ,illu/ration3 ,fig4 #a4--,photographic reproductions f ! ,m$ical ,times4 ,d ! g5tlem5 ^: names appe> 9 ! li/ ( ! 8,bo>d ( ,contribut+ ,editors0 realize t !y are l5d+ an air ( respectability to an o!rwise disreputable bus9ess8 ,& ?is is f ,virg9ia3 8,to ! ,editor3--,! /atem5ts made 9 ! adv]tisem5t ( ! ,kellam ,hospital 9 ! ,octob] numb] ( ! ,m$ical ,times are s out ( ! ord9>y t ,i ask y to tell u some?+ if y c ( _! in/itution & its me?ods ( cure4 ,c su* ?+s z are /at$ 9 ?is adv]tisem5t be true8 #8,physicians ,treat$ ,free8' #8,endors$ by ! ,s5ate & ,legislature ( ,virg9ia8' ,:at c all ?is mean to ! suff]] f canc]8 ,if true1 let ! :ole _w ( suff]]s "k ! glori\s news40 ,colli]'s paid its respects to ! ,kellam conc]n "s "t ago & we _c d bett] ?an quote f its pages4 ,?us3 ,illu/ration3 ,fig4 #b4--,"o way ( drumm+ up trade 9 ! 8canc] cure0 bus9ess6 ,! ,kellam ,hospital s5ds lett]s l ?is to ! po/ma/]s ( small t[ns ask+ ^! gov]nm5t (ficials to furni% x ) :at1 9 ! p>lance ( quack]y1 is kn[n z a 8suck] li/40 ,a delightful bus9ess1 isn't x8 ,& ?is1 g5tlem5 ( ! 8,bo>d ( ,contribut+ ,editors10 is ! sort ( ?+ to :i* y are l5d+ y\r influ5ce & good names6 8,grief is ! portion ( ! ,kellam ,canc] ,hospital1 ( ,ri*mond1 ,virg9ia1 because 9 ^! editorials x has be5 gr\p$ ) o!r exempl>s ( ! ,great ,am]ican ,fraud4 ,x (f]s ! inv>iable & holl[ mock]y ( te/imonials & endorsem5ts1 :i*1 z has be5 repeat$ly %[n1 c be :e$l$1 br[beat5 or brib$ out ( ! victims ( any =m ( quack]y4 ,x1 ( c\rse1 c\rts ! fulle/ inve/igation1 & desires t we s5d a repres5tative to inve/igate :e!r its claims are n well f\nd$4 ,unsuspect$ by ! ,messrs4 ,kellam1 our repres5tative has already inve/igat$ _! claims1 notably _! /atem5t t !y are endors$ by ! ,legislature ( ! ,/ate ( ,virg9ia4 ,^u reque/ = a copy ( ! endorsem5t !y =w>d$ a weak subt]fuge1 & f9ally1 on pressure1 admitt$ t !y c\ld n produce ! pro( !y _h boa/$4 ,= _! fur!r consid]ation we pres5t a brief p>allel3 ,,f ,,! ,,kellam ,,circul> ,,f ,a ,,kellam ,,lett] ,! ,canc] is remov$ )\t ,we d n claim to 8cure !m ! use ( ! knife or ,x-,ray all40 ,we g fur!r1 & on 444 ,no roots or fib]s left2 our "p1 we agree to treat1 free h5ce x c n return4 ( *>ge1 any pati5t :o suff]s a recurr5ce aft] hav+ be5 treat$ by our me?od4 8,! italics are our own1 b we *e]fully pres5t !m = elucidation to ! ,kellam ,hospital4 ,a little c>eful ?\ght devot$ to reconcil+ ! irreconcilable may help !m to =get _! woe4 ,mean:ile1 !y make !mselves out worse ?an !y really are by pret5d+ to )hold f ! bitt] ne$ ( humanity a true1 non-surgical cure = canc]4 ,if ?is 7 true2 if1 inde$1 !y _h solv$ ! problem :i* has baffl$ ! greate/ m9ds ( mod]n sci5ce2 if1 hav+ a g5u9e cure = ! dreadful ailm5t :i* claims its increas+ ?\s&s ( tortur$ victims ye>ly1 !y secrete _! discov]y = ! sake ( a few paltry doll>s1 !n !y are z cold-he>t$ z ! sailors :o pass )9 fair hail ( ! nak$ isl& on :i* "s %ipwreck$ crew is />v+1 & keep _! /ony eyes on ! compass4 ,!y h n ev5 ! excuse ( ! fanatical among ! ,*ri/ian ,sci5ti/s :o1 d5y+ ! exi/5ce ( pa91 refuse to take measures to ease ! canc] victim's suff]+ ev5 at ! la/4 ,human nature is seldom s call\s40 ,z = ! ,m$ical ,times3 ,?is publication = ye>s conta9$ comp>atively little adv]tis+4 ,!n x came into ! h&s ( ,roma9e ,pi]son1 :o also owns ! ,practical ,druggi/4 ,mr4 ,pi]son is n a physician & to him ! m$ical pr(ession is b a comm]cial problem4 ,he is publi%+ a m$ical j\rnal = ! money !re is 9 x1 & = ?is he is n to be c5sur$4 ,que/ions ( adv]tis+ policy1 9 su* circum/ances1 are det]m9$ on a comm]cial basis4 ,:5 an adv]tis+ contract is submitt$1 = a product t physicians w\ld "k to be fraudul5t1 ! "q t arises is1 8,c x be put ov]80 ,manife/ly1 a m$ical j\rnal publi%$ purely z a bus9ess v5ture w\ld n d>e long to fly 9 ! face ( ! op9ions ( ^? f :om x receiv$ its support--its subscrib]s & contributors4 ,if our correspond5ts w g ?r\gh ! adv]tis+ columns ( ! ,m$ical ,times !y w f9d _m1 _m o!r frauds1 less cruel p]haps ?an ! ,kellam adv]tisem5t1 b no less disreputable or discr$itable to ! m$ical pr(ession4 ,aft] all is said & done1 x is enlight5$ public op9ion t is caus+ publi%]s ( lay magaz9es & newspap]s to elim9ate fraudul5t 8pat5t m$ic9e0 & quack adv]tisem5ts4 ,until ! m$ical pr(ession takes an equally enlight5$ /&1 physicians may expect to be afflict$ ) su* comm]cial m$ical j\rnals z ! ,m$ical ,times1 ! ,int]national ,j\rnal ( ,surg]y1 ! ,am]ican ,j\rnal ( ,surg]y1 ,am]ican ,m$ic9e1 & sev]al o!r pap]s t are publi%$ prim>ily 9 ! int]e/ ( ! adv]tis]4 ,:5 su* j\rnals z ^! f9d !y _c get a circulation among physicians s long z !y c>ry adv]tisem5ts simil> to _m n[ appe>+ 9 _! pages1 ^! adv]tisem5ts w be elim9at$1 b n be=e4 ,_m physicians are receiv+ su* j\rnals at a nom9al price or1 z "o ( our correspond5ts notes1 free4 ,! physician :o p]mits su* j\rnals to come to 8 (fice mu/ %>e ) ! paid subscrib]s ! responsibility = ! l[ /&>d ( m$ical j\rnalism4--7,f ! ,j\rnal ,a4 ,m4 ,a41 ,oct4 #ah1 #aiac47 ,two ,physicians ,express ,!mselves on ! ,e?ics ( ,m$ical ,j\rnalism ,aft] ! prec$+ article 0 9 type1 we receiv$1 9 ! same mail1 two lett]s t are s apropos t we reproduce !m4 ,! fir/ 0 f a t[n 9 ,ill9ois1 & 0 dat$ ,octob] #aa4 ,"h x is3 ,to ! ,editor3--,ab\t two weeks ago1 a repres5tative ( ! ,surg]y ,publi%+ ,company1 ,new ,york1 ,n4 ,y41 came to ---- ,ill4 solicit+ subscriptions = ! ,am]ican ,j\rnal ( ,surg]y4 ,toge!r ) num]\s o!rs ,i subscrib$--*iefly on ! /r5g? ( ! contributors ^: articles appe>$ 9 ! sample numb]s %[n by ! ag5t4 ,s9ce receiv+ ! fir/ numb] 7,octob]7 "o look at ! adv]tis+ pages has %[n me :y ! subscription price = a ye> & a qu>t] is "o doll>4 ,anas>c91 ,tongal9e1 ,cact9a ,pillets1 ,hagee's ,cordial ( ,ext4 ,cod ,liv]1 ,burnham's ,soluble ,iod91 ,pap9e1 ,ph5alg9e1 ,anusol1 etc41 etc4 ,i h writt5 to ! ,surg]y ,publi%+ ,company1 tell+ !m 9 no unc]ta9 language t !re is no room on my read+ desk = su*4 ,h y ev] expos$ ?is j\rnal1 & ! attitude ( our big1 brilliant1 em95t m5 9 p]mitt+ _! articles--presumably orig9al--to fill space 9 su* a j\rnal8 ,yes6 ,! ,j\rnal1 ,dec4 #af1 #aiaa1 pp4 #b1jjj & #b1jac4 ,?is lett] is n = publication--at lea/ n ) "n ( city4 ,keep up ! good "w4444 ,! o!r1 dat$ ,octob] #aj1 foll[s3 ,to ! ,editor3--,t little /ory ab\t m$ical j\rnal adv]tis+ & me?ods ( obta9+ paid-up subscrib]s1 9 ?is week's ,j\rnal makes me blu% 7p4 #dbb1 ?is book74 ,i am guilty4 ,unlike ,dr4 ,g5ella1 ,i swall[$ ! bait--b ! bait 0 ev5 m tempt+ 9 my case2 ! flatt]+ 8editor0 (f]$ me tw5ty-five subscriptions to di/ribute among my fri5ds1 all = an 8ab/ract40 ,?ank goodness1 ,i only accept$ five subscriptions1 b worse luck1 ,i s5t !m to "y m5 by pref]5ce4 ,s ,i am a deep-dy$ (f5d] inde$4 ,ext5uat+ circum/ances affect$ my susceptibility some:at1 h[ev]4 ,i h notic$ t prom95t m5 l ,bev]ly ,rob9son1 ,a4 ,rose1 ,tom ,a4 ,williams1 ,wayne ,babcock1 & ,morris--! latt]1 at lea/1 a really able man & a brilliant writ]--contribute to ^! peanut j\rnals occasionally4 ,if !y d1 :y n ,i8 ,!re's no?+ l be+ 9 big company1 y "k4 ,s f> z ,i "k1 my 8ab/ract0 has n yet be5 publi%$4 ,on look+ ov] ! sample copy ( ?is mon?ly ,i f\nd an adv]tisem5t pr9t$ "r 9 ! li/ ( cont5ts--9 fact1 x 0 ! second 8orig9al article0 9 ! issue1 z brave & respectable z y please6 ,!n1 ) *>act]i/ic ,hib]nian impetuosity ,i got out my ma*9e & p\nd$ t editor a /rong prote/ ) a dire comm& n to use my 8ab/ract0 9 8 mis]able organ4 ,b ,i h nev] receiv$ ! manuscript1 nor any reply to my /]n rebuke4 ,i wi% ,i _h be5 cauti\s l ,dr4 ,g5ella4 ,wm4 ,brady1 ,m4,d41 ,elmira1 ,n4 ,y4 --7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,oct4 #ah1 #aiac47 ,! ,responsibility ( ,physicians ,! responsibility ( m$ical j\rnals = ! cont9u$ exi/5ce ( at lea/ a "p ( ! 8great ,am]ican fraud10 has be5 ref]r$ to 9 ^! pages _m times4 ,)9 ! pa/ few weeks ,! ,j\rnal has call$ att5tion to ! inconsi/5cy ( reputable physicians ( high ideals l5d+ _! moral1 & (t5 f9ancial1 support to ^? m$ical j\rnals ^: adv]tis+ pages are a disgrace to ! pr(ession4 ,specifically1 ! ,m$ical ,times--orig9ally a homeopa?ic m$ical j\rnal--has be5 ref]r$ to1 among o!rs1 z an example ( ?is type ( j\rnalism4 ,x mu/1 h[ev]1 be reg>d$ simply z a type1 = x is no bett] & no worse ?an _m o!r m$ical j\rnals4 ,sev]al lett]s h be5 receiv$ on ! subject1 "s ( :i* we reproduce4 ,! fir/ "o is f ,dr4 ,george ,g4 ,ross ( ,philadelphia3 8,i 0 v mu* j>r$ on receiv+ ! la/ issue ( ,! ,j\rnal to f9d "u ! ,propag&a = ,re=m an article conc]n+ ! ,m$ical ,times1 among ! li/ ( ^: contribut+ editors my "n appe>s4 ,i enclose y h]e) a copy ( my lett] ( resignation to ! ,m$ical ,times4 ,i h a v dim recollection ( :at occurr$ at ! "t t ,i 0 ask$ to give my "n z a contribut+ editor4 ,z ,i recollect x1 h[ev]1 at t "t ! j\rnal 0 a respectable & e?ical publication4 ,i _h be5 ask$ by a fri5d ( m9e to write an article giv+ my op9ion ( ! effects ( college a?letics on und]graduates4 ,?is 0 at ! "t t ,dr4 ,/okes _h issu$ 8 ord] ab\t a?letics at ,annapolis4 ,i want p]sonally to ?ank y & ! committee = ! exposure ( ?is j\rnal & = hav+ drawn my att5tion to ! fact t ,i 0 unwitt+ly aid+ & abett+ su* a j\rnal4 ,i tru/ t if y h space 9 "s future numb] ( ,! ,j\rnal1 y w d me ! ju/ice to publi% all or "p ( ?is lett]40 ,because he feels t he has 8unwitt+ly be5 put 9 an unfavorable light10 ,dr4 ,james ,a4 ,babbitt1 also ( ,philadelphia1 s5ds ,! ,j\rnal a copy ( a lett] writt5 by him to ! editor ( ! ,m$ical ,times4 ,"h x is3 8,= reasons ( :i* y are probably cognizant1 ,i deem x advisable to resign f ! bo>d ( contribut+ editors ( ! ,m$ical ,times1 & desire t ?is resignation be accept$ at once & my "n n appe> 9 fur!r issues40 ,:at %all be done1 asks ,dr4 ,sidney ,?ompson ( ,humboldt1 ,t5nessee1 9 su* cases z ! foll[+8 ,says ,dr4 ,?ompson3 8,9 ! ,propag&a = ,re=m1 9 ,! ,j\rnal1 ,octob] #ah1 #aiac1 9 clos+ y\r article on #8,m$ical ,j\rnals & ! ,great ,am]ican ,fraud1' y say3 #8,! physician :o p]mits su* j\rnals to come to 8 (fice mu/ %>e ) ! paid subscrib]s ! responsibility = ! l[ /&>d ( m$ical j\rnalism4' ,n[ ,i agree ) y 9 ev]y?+ y h said ab\t ! ,m$ical ,times1 b :at ,i want to "k is h[ to keep su* j\rnals f com+ into y\r (fice4 ,! ,m$ical ,times has be5 com+ to me = a numb] ( ye>s ) repeat$ duns = ! subscription price4 ,i h writt5 to !m sev]al times t ,i did n want ! j\rnal & nev] expect$ to pay = x1 b /ill x comes4 ,i h a vague recollection t ,i bit at an (f] to s5d x ?ree or f\r mon?s free1 n kn[+ :at x 01 b ,i nev] au?oriz$ !m to ent] my "n z a regul> subscrib]40 ,! simple/ c\rse 9 su* a case z t describ$ by ,dr4 ,?ompson1 is to write on ! unwelcome publication ! ^w 8refus$0 & ei!r drop x 9 ! ne>e/ mail-box or h& x back to ! po/man4 ,! c\rts h held t a p]son :o cont9ues to accept publications is legally liable = ! paym5t ( su* publications4 ,! po/(fice dep>tm5t1 h[ev]1 has rul$ t a magaz9e--ei!r mon?ly or weekly--may n be s5t at second-class rates = m ?an "o ye> aft] ! expiration ( a bona fide subscription4 ,at ! expiration ( t "t1 /amps mu/ be affix$ & ! publications s5t at ?ird-class po/al rates4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #a1 #aiac47 ,m$ical ,j\rnals & ,sanatog5,,bi ,,bi ,see also ,sanatog51 p4 #ceh4 ,we h frequ5tly ref]r$ to ! inquiries t are receiv$ by ?is (fice f newspap] & magaz9e editors ask+ = in=mation ab\t products ^: adv]tisem5ts !y h be5 (f]$4 ,"o ( ! greate/ difficulties 9 ! way ( accompli%+ ! good t su* inquiries o!rwise might lead to is ! lack ( uni=m action on ! "p ( ! m$ical press ( ! c\ntry4 ,a specific in/ance may be giv54 ,a layman wrote to a high-glass weekly magaz9e publi%$ 9 ,new ,york ,city prote/+ aga9/ an adv]tisem5t ( ,sanatog5 :i* ! magaz9e 0 c>ry+1 & s5d+ a repr9t ( ,! ,j\rnal's article on ?is product4 ,! adv]tis+ manag] ( ! magaz9e 9 "q wrote back t he _h se5 ,! ,j\rnal's article1 b _h s\ght fur!r in=mation reg>d+ ! prep>ation f ! editor ( a m$ical j\rnal 9 8 city4 ,! m$ical editor recomm5d$ t ! magaz9e accept ! ,sanatog5 adv]tisem5t1 s ! adv]tis+ manag] said1 & 9 view ( ?is1 ! manag] sugge/$ t possibly ! article publi%$ by ! ,am]ican ,m$ical ,association 9 its j\rnal 0 inspir$ by "s 8p]sonal prejudice40 ,giv+ weight to ! probability t ! adv]tis+ manag] w5t = 8 in=mation to a s\rce t he knew w\ld be favorable to ! acceptance ( ! adv]tisem5t1 ! fact rema9s t x is a disgraceful /ate ( affairs :5 editors ( m$ical j\rnals w give vici\s advice 9 matt]s on :i* !y are suppos$ly compet5t to pass4 ,! probability is1 ( c\rse1 t ! m$ical j\rnal ^: editor 0 que/ion$ conta9$ ! self-same adv]tisem5t t ! lay magaz9e 0 c>ry+4 ,& ! adv]tis+ manag] ( ! magaz9e 0 will+ to accept--because su* in=mation co9cid$ ) 8 wi%es--in=mation t on its face mu/ be bias$1 & reject$ advice--t did n meet 8 approval--because ( a purely supposititi\s 8p]sonal prejudice40 ,x is probably ask+ too mu* to expect adv]tis+ manag]s n to g to s\rces t are likely to be favorable = in=mation ab\t products ^: adv]tisem5ts are (f]$ to !m4 ,b we h a "r to expect t physicians1 editors ( m$ical j\rnals1 %\ld no long] be p>ticipes crim9is 9 ! fur!rance ( ! great ,am]ican fraud4 ,if our /rictures on ,sanatog5 are unfair1 if ! ,c\ncil on ,ph>macy & ,*emi/ry reject$ ! product 9 m]e pique1 if ! op9ions ( su* m5 z ,bill+s1 ,cabot1 ,hekto5 & ,lusk are to be bru%$ aside z 8p]sonal prejudice10 if ?is mixture ( cottage *eese & glyc]ophosphates really is ! m>vel\s product :i* its exploit]s claim--!n inde$ n only h ! editors ( m$ical j\rnals a "r to praise x1 b x is also _! duty to proclaim ^! wond]s 9 _! editorial pages4 ,if1 on ! o!r h&1 ?is mu*-vaunt$ prep>ation is a v ord9>y mixture sold at an extraord9>y price1 if indig5t consumptives & o!rs are be+ inveigl$ into sp5d+ doll>s = a prep>ation ^: food value c\ld be duplicat$ = a few c5ts--!n 9 ! "n ( humanity & common dec5cy let ! editors ( m$ical j\rnals proclaim ^! facts1 & n let _! sci5tific judgm5t be bl9d$ by ! glitt] ( adv]tis+ contracts4--7,modifi$ f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #ah1 #aiac47 ,,! ,,army ,,& ,,navy ,,m$ical ,,record ,a ,fraudul5t ,publication ,^: ,editorial ,op9ions ,are = ,sale ,:5ev] a bus9ess assumes c]ta9 proportions1 subsidi>y bus9esses spr+ up to cat] to ! ne$s ( ! l>g] ent]prise4 ,= "s ye>s ! no/rum bus9ess has gr[n s l>ge t x has furni%$ a m or less prec>i\s life = _m individuals :o h cat]$ to x4 ,!re are1 = in/ance1 m5 ^: trade x is to obta9 te/imonials2 o!rs1 claim+ a long /r+ ( impos+ degrees1 w furni% fake reports & bogus analyses2 /ill o!rs issue at irregul> int]vals publications ) high-s\nd+ names :i* sell editorial indorsem5t to ! products ( conc]ns su* z are will+ to pay ! price ask$4 8,j\rnals0 ( ?is type h be5 call$ to ! att5tion ( our read]s at diff]5t times2 ! ,new ,york ,heal? ,j\rnal & ! ,unit$ ,/ates ,heal? ,reports come to m9d at ?is mom5t4 ,bo? ( ^! _h _! day & di$ a natural dea?1 z all su* publications mu/ :5 once ! public is cognizant ( _! true "*4 ,,two ,,lett]s ,m rec5tly ! att5tion ( ,! ,j\rnal has be5 call$ to a publication call+ itself ! ,army & ,navy ,m$ical ,record4 ,a physician 9 ! ,s\? s5ds a lett] he has receiv$ f ! ,army & ,navy ,m$ical ,record read+ z foll[s3 8,we h _h _m favorable reports rea* u relative to y\r mo/ excell5t in/itution1 &1 z y are d\btless aw>e1 we come 9 direct contact ) a l>ge numb] ( ,army & ,navy & o!r gov]nm5t atta*s :o h sons t !y desire to provide ) a m$ical education comb9$ ) ! high] c\rse includ$ 9 y\r up-to-date laboratory me?ods & ! sci5ces incid5tal to cl9ical m$ical practice4 8,if y w reg>d ! proposition z confid5tial1 we w agree to c>ry a "o-f\r? page adv]tisem5t ( y\r univ]sity at ! nom9al rate ( #ch p] ye>1 provid$ ?is am\nt is =w>d$ 9 advance at ! "t copy is furni%$2 & we w fur!r promise to editorially indorse & recomm5d y\r s*ool & its me?ods )\t qualification or exception4 ,our italics4--,ed4 ,?is article y %\ld be able to use 7& are au?oriz$ to d s7 aft] publication = adv]tis+ purposes4 8,we w also be able1 & are will+1 to furni% y ) a desirable li/ ( probable c&idates f "t to "t4 8,k9dly let u he> f y at once1 if int]e/$1 & oblige1 8,y\rs ) be/ wi%es1 8,! ,army & ,navy ,m$ical ,record1 8,ar?ur ,g4 ,lewis1 ,manag+ ,editor40 ,! physician to :om ?is 0 address$ made a notation on ! lett] to ! effect t 8?is looks crook$40 ,a few weeks lat]1 ,dr4 ,v4 ,c4 ,vaughan1 dean ( ! ,univ]sity ( ,mi*igan1 ,dep>tm5t ( ,m$ic9e & ,surg]y1 s5t 9 a lett] f ! ,army & ,navy ,m$ical ,record :i* he _h receiv$ 9 8 (ficial capacity at ! univ]sity4 ,"h is ! lett]2 aga9 ! italics are ours3 8,we are gratifi$ to advise y t 9 our ef=ts to select a /rictly e?ical & high-grade in/itution ( m$ic9e t ?is magaz9e c\ld consi/5tly indorse & recomm5d1 we h decid$ on ! ,univ]sity ( ,mi*igan1 ,dep>tm5t ( ,m$ic9e & ,surg]y1 z ! in/itution 9 y\r t]ritory to :om our special publicity concession w be made ?is ye>4 8,y are d\btless aw>e t we come 9 direct contact ) a v l>ge numb] ( ,army & ,navy & o!r gov]nm5t atta*s1 also physicians 9 private practice :o h sons t !y desire to provide ) a m$ical education1 comb9$ ) ! high] c\rses includ$ 9 y\r up-to-date me?ods4 8,= p]sonal reasons we are p>ticul>ly anxi\s to favor y\r in/itution1 & frankly believe t we c prove ( mat]ial s]vice to y4 ,! special proposition1 to be reg>d$ by y z /rictly confid5tial1 is t we w publi% a full "o-half page ann\ncem5t ( y\r in/itution = ! t]m ( "o ye>1 y to m]ely pay a nom9al exp5se *>ge ( #ch = ! ye>'s s]vice4 ,z our regul> rate is #abe p] annum = ?is s]vice1 ! necessity ( reg>d+ ! matt] betwe5 ourselves is app>5t4 ,transp>5tly s4--,ed4 ,we fur!r propose1 )\t exp5se to y1 to editorially indorse & recomm5d y\r in/itution & its me?ods )\t qualification or exception4 ,an electrotype illu/ration may be us$1 )\t *>ge4 8,x is important1 h[ev]1 t we he> f y promptly4 ,await+ y\r imm$iate reply1 we are1 ) be/ wi%es1 8,y\rs fai?fully1 8,! ,army & ,navy ,m$ical ,record1 8,ar?ur ,g4 ,lewis1 ,manag+ ,editor40 ,dr4 ,vaughan1 9 =w>d+ ! matt] to ,! ,j\rnal1 wrote t on receipt ( ! (f] j giv51 he 80 unc]ta9 :e!r its writ] 0 a knave or a fool40 ,aft] inquir+ into ! matt] some:at ?or\ghly1 he conclud$ t 8! manag+ editor ( ! ,army & ,navy ,m$ical ,record is bo? a knave & a fool40 ,,! ,,army ,,& ,,navy ,,magaz9e ,! ,j\rnal _h ! ,army & ,navy ,m$ical ,record "u inve/igation be=e ^! two lett]s 7 receiv$ &1 z a result1 ! foll[+ facts seem to be pretty well sub/antiat$4 ,h]b]t ,c4 ,lewis1 ) 8 bro!r1 ,ar?ur ,g41 conduct$ f ,wa%+ton1 ,d4 ,c41 a publication call$ ! ,army & ,navy ,magaz9e4 ,9 ,! ,j\rnal's no/rum file !re is a booklet put out by ! ,r5ova ,di/ribut+ ,company describ+ ! wond]ful virtues ( its product1 8,anti-,jag10 :i*1 z its "n might intimate1 is a 8liquor cure0 ( ! fake v>iety4 ,"o page ( ?is booklet is giv5 ov] to :at purports to be 8,a ,lett] f a ,great ,magaz9e ,editor40 ,! lett] is dat$ ,june #ai1 #aijj1 f ,wa%+ton1 ,d4 ,c41 & says t 8! editor ( ! ,army & ,navy ,magaz9e takes pleasure 9 /at+ t f 8 own p]sonal k he has f\nd #8,anti-,jag' to be "o ( ! mo/ reliable m$ic9es ev] introduc$ = ! p]man5t cure ( drunk5ness40 ,& m to ! same effect4 ,! lett] is sign$ 8,h]b]t ,c4 ,lewis1 editor40 ,! publi%+ (fices ( ! ,army & ,navy ,magaz9e are at #fjf ,f ,/reet1 ,n4 ,w41 ,wa%+ton1 ,d4 ,c4 ,! build+ at ?is address is kn[n z ! ,baltic ,build+4 ,h]b]t ,c4 ,lewis is said to be a pr9t] by trade4 ,! ,army & ,navy ,m$ical ,record seems to h be5 />t$ )9 ! la/ few mon?s by ,ar?ur ,g4 ,lewis4 ,x does bus9ess f two addresses1 ! ,baltic ,build+1 ,wa%+ton1 ,d4 ,c41 & ! ,maple ,villa ,sanit>ium1 ,hammonton1 ,n4 ,j4 ,lewis is said to h pur*as$ ! ,maple ,villa ,sanit>ium rec5tly1 b app>5tly 8 *ief s\rce ( income is ! ,army & ,navy ,m$ical ,record4 ,he is alleg$ to h claim$ t "s m$ical (ficials ( ! gov]nm5t are int]e/$ ) him 9 ?is publication b t ^! (ficials d n wi% _! names kn[n4 ,we d n blame !m4 ,illu/ration3 ,photographic facsimile ( a lett] s5t by ! ,army & ,navy ,m$ical ,record to ! dean ( ,univ]sity ( ,mi*igan1 ,dep>tm5t ( ,m$ic9e & ,surg]y1 (f]+ "o hundr$ & tw5ty-five doll>s' wor? ( adv]tis+ space = a 8nom9al0 ?irty-eight doll>s--) editorial indorsem5ts & recomm5dations ?r[n 9 = good measure6 ,,adv]tisem5ts ,,z ,,editorials ,a glance ?r\gh two issues ( ! ,army & ,navy ,m$ical ,record makes p]fectly pla9 ! "* ( ! publication4 ,! ,janu>y-,febru>y1 #aiac1 numb] leads (f ) articles by well-kn[n m$ical (fic]s 9 ! ,army1 ! ,navy & ! ,public ,heal? ,s]vice4 ,^! h be5 copi$ f o!r publications4 ,!n comes an editorial entitl$ 8,a ,mu* ,ne$$ ,diet>y ,re=m10 devot$ to ! laudation ( 8,po/um10 ! widely adv]tis$ c(fee sub/itute4 ,foll[+ ?is is an editorial on 8,! ,philosophy ( ,hypnotics0 9 :i* aconit9e1 sal9e laxative & digital9 are ea* giv5 a 8boo/40 ,!n comes an 8orig9al article0 7save ! m>k67 entitl$ 8,! ,physiological ,pa?ology ( ,consumption40 ,?is is by 8,alfr$ ,s4 ,gubb1 ,m4,d41 ,l4,r4,c4,p41 ,london1 ,m4,r4,c4,s41 ,eng41 ,d4,p4,h41 etc4 etc41 ,aix-les-,ba9s1 ,savoie1 ,france40 ,two pages are devot$ to ?is4 ,! 8jok]0 appe>s 9 ! ?ird p>agraphs f ! end--,fell[s' ,syrup ( ,hypophosphites4 ,dioxog5 receives m ?an ?ree pages ( editorial m5tion "u ! caption 8,! ,/]ilization ( ,milk ) ,dioxog540 ,"u 8,ano!r ,new ,electrical ,wond]--,magnifi$ ,s\nd10 ! 8,ac\/icon0 is giv5 a two-&-a-qu>t] page write-up4 8,:at ,wise ,m5 ,we>0 is ! title ( a f\r-page article--unsign$--devot$ to ! laudation ( susp5sories 9 g5]al & ! 8,o-,p-,c ,susp5sory0 9 p>ticul>4 ,dr4 ,h4 ,f4 ,boatman1 ,los ,angeles1 contributes a %ort article on 8,a ,case ( ,advanc$ ,pulmonic ,tub]culosis ,treat$ ) ,injections ( ,diorad910 :ile our good old fri5d ,will>d ,h4 ,morse1 ,m4,d41 8,f4,s4,sc4 7,lond4710 ! *ampion fake-te/imonial-giv] ( ! c\ntry1 writes m or less ent]ta9+ly on 8,putt+ on a ,mu/>d ,pla/]40 ,! article has no?+ to d ) mu/>d pla/]s b has a good deal to d ) 8,zumota10 a no/rum recomm5d$ z a sub/itute = ! mu/>d pla/]4 ,^! are b a few ( ! no/rums to :i* ! editorial & read+ pages ( ! ,army & ,navy ,m$ical ,record are devot$4 ,9 ! ,june-,july issue1 ,ar?ur ,g4 ,lewis becomes bold]4 ,! lead+ article is entitl$ 8,fir/ ,aid 9 ! ,navy10 by ,c4 ,f4 ,/okes1 ,surgeon-,g5]al1 ,unit$ ,/ates ,navy4 ,!re is no?+ to indicate t ?is article 0 n contribut$ to ! ,army & ,navy ,m$ical ,record by its au?or4 ,z a matt] ( fact1 x orig9ally appe>$ 9 an (ficial publication1 ! ,unit$ ,/ates ,naval ,m$ical ,bullet9 = ,janu>y1 #aiac1 & 0 repr9t$ by ,lewis )\t cr$it & )\t p]mission4 ,foll[+ ! article by ,dr4 ,/okes is ano!r1 unsign$1 entitl$ 8,! ,pass+ ( #8,! ,pie ,habit4'0 ,?is describes ! surprise ( ! /ud5ts ( ,h>v>d ,univ]sity at be+ s]v$ breakfa/ c]eals in/ead ( pie at _! noonday meal & sugge/s t 8,%r$d$ ,:eat ,biscuits0 make a 8delici\s dess]t40 ,a two-&-a-half page article on ! 8,dang] ( ,corrosive ,sublimate 9 ,vag9al ,d\*e0 is repr9t$ f ! ,lancet-,cl9ic ( ,septemb]1 #aijc4 ,! reason = resurrect+ ?is t5-ye>-old article becomes app>5t be=e "o gets half ?r\gh x4 ,x deals n s mu* ) ! dang] ( corrosive sublimate z ) ! m>vel\s--alleg$--prop]ties ( ,tyree's ,antiseptic ,p[d]4 ,dr4 ,claude ,c4 ,keel]1 ,d5v]1 has a ?ree-page article on ! 8,m$ical ,treatm5t ( ,pulmon>y ,tub]culosis40 ,! 8m$ical treatm5t0 ref]r$ to is ,wat]bury's ,comp\nd4 ,an editorial entitl$ 8,"o ,not* ,ahead ( ,morph90 is devot$ to t vici\s morph9 solution sold "u ! propriet>y "n 8,pap9e40 ,ano!r on 8,! ,treatm5t ( ,cat>rh by ,palliatives & ,curatives0 deals ) a widely adv]tis$ 8pat5t m$ic9e10 8,kondon's ,cat>rhal ,jelly40 ,:at appe>s to be a contribut$ article by ,*>les ,w>dell ,/iles ( ! ,unit$ ,/ates ,public ,heal? ,s]vice on 8,c\ntry ,s*ools & ,rural ,sanitation0 has really be5 8lift$0 f an (ficial publication )\t cr$it &1 ne$less to say1 )\t ,dr4 ,/iles' p]mission4 ,b m$ic9al prep>ations are n ! only ?+s to :i* ! ,army & ,navy ,m$ical ,record gives editorial indorsem5t4 ,all adv]tis+ matt]1 app>5tly1 is gri/ to its mill4 ,s&wi*$ 9 betwe5 articles on 8,public ,heal? ,adm9i/rations0 & 8,important ,army ,m$ical ,lectures0 is a diss]tation on 8,! ,mill5nium ( ,%irt ,con/ruction10 9 :i* are sung ! virtues ( ! tailless %irt6 ,a little f>!r along ! ,hawaiian p9eapple is extoll$1 :ile ! la/ pages ( ! issue are devot$ to v>i\s bank+ conc]ns4 ,9 addition to ! adv]tisem5ts appe>+ ?r\gh\t ! read+ & editorial pages ( ^! two issues ( ! ,army & ,navy ,m$ical ,record1 !re are a numb] ( display adv]tisem5ts4 ,!re is no reason to suppose1 at lea/ 9 ! majority ( cases1 t ! adv]tis]s _h ! slighte/ reason to suspect ! nature ( ! ,army & ,navy ,m$ical ,record4 ,sev]al pages are devot$ to f9ancial adv]tisem5ts1 !re be+ m ?an =ty banks t h 8fall5 =0 ! wiles ( ,ar?ur ,g4 ,lewis4 ,9 view ( ! lett]s receiv$ by ! deans ( m$ical colleges & o!r educational in/itutions1 ! display adv]tisem5ts ( s*ools & colleges h a special int]e/ to physicians4 ,s*ools = girls1 polyte*nics1 colleges ( music1 vet]9>y1 d5tal & m$ical s*ools--all are to be f\nd 9 ?is cosmopolitan publication4 ,among ! !rapeutic products adv]tis$--9 ! adv]tis+ pages--are3 ,fell[s' ,syrup ( ,hypophosphites #a cov] page ,kondon's ,cat>rhal ,jelly #a_/b page ,expurgo ,anti-,diabetes #a_/b page ,laxol #a_/b page ,campho-,phnique #a_/b page ,palpebr9e #a_/b page ,zumota #a_/b page ,sanmetto #a_/d page ,:ile 9 ! read+ pages ! foll[+ products are puff$3 ,tyree's ,antiseptic ,p[d]4 ,wat]bury's ,comp\nd4 ,pap9e4 ,kondon's ,cat>rhal ,jelly4 ,rani] ,natural ,soap4 ,iodia 7,battle74 ,creo-,d]ma4 ,fell[s' ,syrup ( ,hypophosphites4 ,tannalb94 ,expurgo ,anti-,diabetes4 ,zumota4 ,sulfo!n4 ,dioxog54 ,palpebr9e4 ,bann]man's ,intrav5\s ,solution4 ,daniel's ,conc5trat$ ,t9cture ( ,passiflora4 ,peacock's ,bromides4 ,aletris ,cordial ,rio4 ,gonosan4 ,digipuratum4 ,diorad94 ,pepto-,f]4 ,lactol4 ,campho-,phnique4 ,summ$ up3 ,! ,army & ,navy ,m$ical ,record is b ano!r ( ! p>asites ( quack]y4 ,x is n ent]$ z second-class matt] & x has probably no bona-fide circulation4 ,:ile x is claim$ to be 8,devot$ to ! ,int]e/ ( ! ,m$ical & ,surgical ,corps ( ! ,army & ,navy1 ! ,public ,heal? ,m>9e ,hospital ,s]vice & ! ,r$ ,cross ,society0 x is actually devot$ to none ( ^!4 ,x is devot$ to ! exploitation ( ! adv]tis+ public = ! special f9ancial b5efit ( ! man :o calls himself its editor--,ar?ur ,g4 ,lewis4 ,adv]tis+ contracts are obta9$ "u false & fraudul5t pret5ses4 ,9 brief1 ,ar?ur ,g4 ,lewis is us+ ! good "n ( ! v>i\s m$ical s]vices ( ! ,unit$ ,/ates gov]nm5t to fur!r 8 sw9dl+ op]ations4 ,he has writt5 lett]s to honorable physicians mak+ di%one/ & insult+ propositions to deceive & defraud ! public4 ,editorial indorsem5ts ( ! ,army & ,navy ,m$ical ,record mean no?+ except t money has be5 paid = !m4 ,9 %ort1 ! ,army & ,navy ,m$ical ,record is a fraud1 & its 8editor10 ,ar?ur ,g4 ,lewis1 a fak]4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,oct4 #be1 #aiac47 ,,! ,,m$ical ,,times ,,adv]tisem5ts ,9 ,:i* ,are ,discuss$ ,"s 8,ov]sights0 & ! ,e?ics ( ,j\rnalism ,two or ?ree weeks ago we publi%$ lett]s f two physicians call+ att5tion to an adv]tisem5t ( a 8canc] cure0 hospital appe>+ 9 ! ,m$ical ,times4 ,z a result ( ,! ,j\rnal's comm5ts1 "s ( ! physicians :o 7 li/$ z 8contribut+ editors0 ( ! ,m$ical ,times wrote t !y _h reque/$ t _! names be )drawn f ?is li/4 ,9 reply to at lea/ "s ( ^! lett]s1 ! editor ( ! ,m$ical ,times wrote ask+ !m to reconsid] _! decision & (f]+ z an excuse ! /atem5t t ! appe>ance ( ! 8canc] cure0 hospital adv]tisem5t 0 an ov]sight4 ,9 ?is connection ! foll[+ lett] f ! ,m$ical ,times1 address$ to ,! ,j\rnal ( ! ,am]ican ,m$ical ,association1 is p]t95t3 8,g5tlem53--,we note 9 y\r issue ( ,octob] #ah an article call+ att5tion to an adv]tisem5t :i* appe>s 9 ! columns ( ?is j\rnal1 & to :i* y\r editor rightly objects4 8,! adv]tisem5t 9 ! ,times 0 ! result ( an ov]sight1 & x w n reappe>4 8,:ile we are indebt$ to y = ?us br++ ! matt] to our att5tion1 we _c b feel t a lett] writt5 to u w\ld h be5 m 9 keep+ ) ! e?ics ( j\rnalism4 8,v truly y\rs1 ,! ,m$ical ,times40 ,x w be notic$ t ?is lett]1 l ! lett]s s5t to o!r physicians1 ignores altoge!r ! mo/ important po9t made by ,! ,j\rnal 9 its criticism ( t publication's adv]tis+ policy4 ,! ,j\rnal said 9 ?is connection3 8,if our correspond5ts w g ?r\gh ! adv]tis+ columns ( ! ,m$ical ,times !y w f9d _m1 _m o!r frauds1 less cruel p]haps ?an ! ,kellam adv]tisem5t1 b no less disreputable or discr$itable to ! m$ical pr(ession40 ,! ,m$ical ,times apologizes = ! adv]tisem5t ( ! ,kellam ,canc] ,cure ,hospital b ignores altoge!r ! fact t ! hospital adv]tisem5t 0 b "o ( _m equally discr$itable4 ,we turn to rec5t issues ( ! ,m$ical ,times & we f9d x fairly reek+ ) adv]tisem5ts ( propriet>y prep>ations t are a disgrace to ! m$ical pr(ession1 _m ( !m hav+ be5 repeat$ly expos$ 9 ,! ,j\rnal4 ,we f9d1 = in/ance1 a qu>t]-page adv]tisem5t ( ! ,expurgo ,manufactur+ ,company4 8,expurgo ,anti-,diabetes10 we are solemnly told 9 ! pages ( ! ,m$ical ,times is3 8,! only reliable & ?or\ghly te/$ rem$y = ! cure ( ,diabetes ,mellitus & ,insipidus40 ,?is wret*$ fraud1 :i* also is adv]tis$ 9 true 8pat5t m$ic9e0 /yle direct to ! public1 is pres5t$ to a presumably intellig5t pr(ession z a 8cure0 = a disease :i* s f> has baffl$ ! be/ bra9s 9 ! sci5tific _w4 8,expurgo ,lapis0 we are told1 also via ! ,m$ical ,times is3 8,! only kn[n cure = gall-/ones1 kidney & bladd] /ones1 gravel & all kidney tr\ble aris+ f uric-acid orig940 ,did ,kilm]'s ,swamp-,root ev] claim m8 8,diabetes is no long] an incurable disease0 runs ! adv]tisem5t ( ! ,jireh ,diabetic ,food ,company1 yet ! editor ( ! ,m$ical ,times mu/ "k t 9 ,! ,j\rnal#acc & 9 ! reports ( /ate *emi/s ! ,jireh diabetic foods h be5 %[n "t & aga9 to be among ! mo/ dang]\s & fraudul5tly exploit$ products sold to ! un=tunate diabetic4 #acc ,! ,j\rnal ,a4 ,m4 ,a41 ,dec4 #ad1 #aiab1 ,m>* #bb1 #aiac1 & ,april #e1 #aiac2 see also p4 #dea1 ?is book4 ,ph5alg91#acd tw9 bro!r to ! ,antikamnia fraud1 %\ts its inf]5tial falsehoods 9 a half-page display4 ,micajah's ,waf]s1#ace ! alum-borax mixture long adv]tis$ z a cure = gonorrhea1 endometritis1 etc41 may also be f\nd1 z well z _m o!r prep>ations expos$ at v>i\s times by ,! ,j\rnal4 ,= example3 ,anas>c91#acf ,campho-,ph5ique1#acg ,pap9e1#ach ,bromidia1#aci ,cact9a ,pillets1#adj ,pluto ,wat]1#ada ,prunoids1#adb ,sanatog5#adc & ,sal ,hepatica4#add #acd ,pages #aj & #cce1 ?is book4 #ace ,page #bdj1 ?is book4 #acf ,page #aa1 ?is book4 #acg ,page #dj1 ?is book4 #ach ,page #ccj1 ?is book4 #aci ,no/rums & ,quack]y1 ,ed4 #b1 p4 #ehi2 page #ca1 ?is book4 #adj ,page #cf1 ?is book4 #ada ,! ,j\rnal1 ,m>* #bi1 #aiac1 p4 #ajac4 #adb ,page #agh1 ?is book4 #adc ,no/rums & ,quack]y1 ,ed4 #b1 p4 #dgj2 page #ceh1 ?is book4 #add ,no/rums & ,quack]y1 ,ed4 #b1 p4 #fci2 page #agi1 ?is book4 ,:at excuse c ! ,m$ical ,times (f] = ! pres5ce ( ^! frauds 9 its pages8 ,are ^!1 too1 8! result ( an ov]sight08 ,presumably = ?us br++ to its att5tion ^! v>i\s o!r disreputable adv]tisem5ts1 ,! ,j\rnal w be accus$ aga9 ( violat+ 8! e?ics ( j\rnalism40 ,if call+ att5tion to fraudul5t adv]tisem5ts is out ( keep+ ) ! e?ics ( j\rnalism1 :at1 pray1 mu/ be said ( publications t are will+ to %>e 9 ! pr(its ( su* fraudul5t exploitation8 ,b1 & we _c repeat x too (t51 ! ,m$ical ,times is b "o ( a class1 nei!r worse nor bett] ?an _m o!r m$ical j\rnals ^: f9ancial support comes f ! propriet>y int]e/s r ?an f ! m$ical pr(ession4 ,! responsibility = ! exi/5ce ( ^! j\rnals really re/s n on ! bus9ess m5 :o conduct !m on a comm]cial basis1 b on ! physicians :o tol]ate or enc\rage !m 9 any way4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,nov4 #h1 #aiac47 ,,cause ,,= ,,optimism ,a ,clean ,m$ical ,j\rnal--! ,s\? ,texas ,m$ical ,record ,=tunately1 !re are =ces at "w 9 ! m$ical pr(ession t make = optimism4 ,an editorial 9 ! la/ issue--,april1 #aiae--( ! ,s\? ,texas ,m$ical ,record1 ! (ficial organ ( ! ,s\? ,texas ,di/rict ,m$ical ,association1 is especially significant4 ,:ile n a l>ge j\rnal1 ! ,s\? ,texas ,m$ical ,record c\ld well /& z an example to m$ical publications ( a mu* m pret5ti\s "*4 ,its adv]tis+ pages are above reproa* & ! j\rnal is a cr$it alike to its editors & to ^? memb]s ( ! pr(ession ^: support makes its exi/5ce possible4 ,9 ! editorial ref]r$ to1 entitl$1 8,hone/ ,adv]tis+--,let ,u ,cleanse ,our ,own ,l95 ,fir/10 ! editor-9-*ief1 ,dr4 ,w4 ,burton ,?orn+1 says3 8,a rec5t editorial1 entitl$ #8,hone/ ,adv]tis+1' 9 a daily newspap]1 furni%$ ! occasion = an editorial comm5t 9 ! ,janu>y numb] ( ! ,s\?we/]n ,hospital ,report]4 ,! latt]1 :ile tak+ ! gr\nd t ! newspap] 0 inconsi/5t 9 utt]+ high editorial s5tim5ts & 9 adjo9+ columns pr9t+ pat5t m$ic9e adv]tisem5ts1 impli$ t newspap] m5 %\ld be all[$ "s latitude 9 ! matt] ( accept+ adv]tis+1 on ! plea ( be+ laym5 & !re=e n expect$ to possess ! same am\nt ( in=mation conc]n+ pat5t #8dope' t m$ical m5 h4 8,x w\ld appe> to be a fair assumption t a layman1 ev5 ?\gh a highly educat$ & able editor ( a great newspap]1 does n "k1 & _c be expect$ to "k1 ! dep? ( depravity to :i* ! consumption cure fak] & ! canc] quack c desc5d4 8,grant+ t ! newspap] man accepts ! adv]tisem5ts ?r\gh ignorance ( ! facts conc]n+ _! possibilities = evil1 :at c be (f]$ 9 def5se ( ! m$ical editor :o accepts adv]tis+ matt] equally p]nici\s 9 its influ5ce8 8,inde$1 x is n s _m ye>s s9ce _m ( ! s-call$ e?ical m$ical j\rnals c>ri$ ! ads ( "s ( ! mo/ notori\s quacks ?is c\ntry has ev] kn[n4 8,d\btless !re are few1 if any1 :o d s at ! pres5t "t1 b1 on ! o!r h&1 !re are only a few :o d n adv]tise une?ical in/itutions1 & que/ionable propriet>y m$ic9es4 ,z a matt] ( fact "s ( ! mo/ widely adv]tis$ pat5t m$ic9es ( today 7 =m]ly adv]tis$ z e?ical propriet>ies 9 m$ical p]iodicals1 ! great majority ( :i* are /ill s]v+ z a sort ( prep>atory s*ool = adv]tisem5ts t w pres5tly appe> 9 ! lay press4 8,:at %all be (f]$ 9 def5se ( ! m$ical publication :i* cont9ues to publi% ! adv]tis+ matt] ( hundr$s ( propriet>ies :i* ! ,c\ncil on ,ph>macy & ,*emi/ry ( ! ,am]ican ,m$ical ,association has %[n to be ei!r g5]ally wor?less or an out & out fake8 8,c ! m$ical editor plead ignorance8 ,h>dly4 ,to d s w\ld be to admit utt] incapacity4 ,!re is only "o inf]5ce to be drawn2 ! publication ne$s ! money & is n ov]p>ticul> reg>d+ its s\rce4 8,!re is a rem$y1 h[ev]1 a rem$y absolutely c]ta9 9 its results4 ,if e physician 9 ! ,unit$ ,/ates = a p]iod ( ?ree mon?s w\ld positively refuse to receive at 8 desk a m$ical j\rnal conta9+ que/ionable adv]tis+1 ?is blot* on m$ical j\rnalism c\ld be eras$4 8,x is true t _m ( !m w\ld s9k1 nev] to rise aga91 b ! pr(ession w\ld be bett] (f )\t ^? ^: exi/5ce dep5ds ^u #8phoney' adv]tis+4 ,!re are1 un=tunately1 sev]al ,am]ican j\rnals ^: read+ pages are well & c>efully edit$ & a cr$it to m$ical lit]ature1 ^: adv]tis+ pages c>ry su* undesirable matt] t ! educat$ physician c only feel a s5se ( disgu/4 8,su* j\rnals c\ld v well succe$ on ! quality ( _! read+ matt] & und\bt$ly w\ld increase _! circulation en\gh to m ?an (fset ! loss 9 adv]tis+40--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,may #bi1 #aiae47 ,,! ,,comp>ative ,,nutri5t ,,value ,,( ,,cod ,,liv] ,,oil ,,& ,,cod ,,liv] ,,oil ,,cordials,,bj ,john ,phillips ,/reet1 ,m4,s4 ,*emi/1 ,connecticut ,agricultural ,exp]im5t ,/ation ,,new ,,hav51 ,,conn4 ,,bj ,see also reports on ,hagee's ,cordial1 pp4 #ea1 #bhi2 ,wampole's ,prep>ation1 pp4 #eb1 #ddb1 & ,wat]bury's ,comp\nd1 pp4 #ed1 #eg1 #bia4 ,= a long "t cod liv] oil has be5 recogniz$ z an easily assimilable nutri5t & recon/ructive & ( special value 9 wa/+ diseases4 ,! unpalatability ( ! oil1 h[ev]1 has l$ to v>i\s devices to make x ta/eless or to r5d] x m acceptable to ! /oma*4 ,emulsions conta9+ ! oil 9 mixture ) o!r sub/ances 7 exploit$1 & d\btless s]v$ a useful purpose4 ,! oil1 h[ev]1 b imp]fectly conceal$1 0 /ill disagreeable to _m1 & o!r prep>ations began to appe> on ! m>ket1 :i* claim$ to reta9 ! !rapeutic virtues ( cod liv] oil )\t its disagreeable *>act]i/ics4 ,?is practice has be5 c>ri$ s f> t n[ we f9d = sale cod liv] oil prep>ations f :i* ! oil has be5 remov$ 9 its entirety1 & only ! "n rema9s4 ,c]ta9 ( ^! products claim to 8repres5t0 ! oil & to reta9 all its virtues2 o!rs are said to conta9 oil1 :ile /ill o!rs claim 8all ! valuable con/itu5ts0 ( ! oil )\t ! oil itself4 ,9 ! pa/1 cod liv] oil has be5 consid]$ a food r ?an a m$ic9e1 & its value attribut$ to ! easily dige/ible & metabolizable oil x conta9s4 ,?is position1 h[ev]1 has be5 disput$4 ,by "s its !rapeutic value has be5 attribut$ to ! small am\nt ( iod9 pres5t 9 ! oil1 b 9 rec5t ye>s ! sugge/ion has be5 made t its special pot5cy dep5ds on its peculi> fatty acids4 ,9 ?is connection ! ,u4 ,s4 ,disp5satory#ade says3 #ade ,u4 ,s4 ,disp5satory1 ,ed4 #ai1 p4 #hfj4 8,o!r oleag9\s sub/ances1 c]ta9ly n less nutriti\s1 h n be5 equally effici5t1 ?\gh tak5 9 mu* l>g] quantities4 ,if ?is be ! true explanation1 p]sons liv+ *iefly on milk1 :i* ab\nds 9 oil1 or on fat pork1 ought to %[ a special exemption f scr(ul\s compla9ts4 ,! probability appe>s to u to be t1 9 consequ5ce ( "s peculi> pr9ciple or pr9ciples x conta9s1 x ex]cises a /imulant & alt]ative influ5ce on ! processes ( assimilation & nutrition1 !reby aid+ 9 ! production ( heal?y tissue40 ,inde$1 ,osborne & ,m5del#adf h %[n 9 _! exp]im5ts on alb9o rats t by sub/itut+ cod liv] oil = a portion ( ! l>d 9 _! /&>d diets1 gr[? 0 resum$ aft] failure on foods conta9+ comm]cial l>d alone z ! s\rce ( fat4 ,simil> results 7 secur$ ) butt]-fat & egg yolk fat4 #adf ,osborne1 ,t4 ,b41 & ,m5del1 ,l4 ,b43 ,j\r4 ,biol4 ,*em41 #aiad1 xvii1 #dja4 ,9 ! light ( ! !ories advanc$ = ! !rapeutic value ( cod liv] oil1 & ! results secur$ by ,osborne & ,m5del ) ! oil itself2 x seem$ a pr(itable /udy to exam9e "s ( ! prom95t 8oilless0 prep>ations on ! m>ket to det]m9e :e!r or n ! claims made = !m z nutri5ts 7 ju/ifi$4 ,c]ta9 ( ! s-call$ cod liv] oil prep>ations are t]m$ 8extracts0 ( cod liv] oil1 & are n made f ! oil1 b f ! cod liv]s in/ead4 ,z has be5 well said1#adg 8,!y are prep>ations1 :i*1 if hone/ly made1 might be wor?y ( trial1 b !y are improp]ly call$ #8extracts' ( cod liv] oil1 s9ce !y d n conta9 ! fat1 :i* is ! active con/itu5t ( ! oil1 b ! extractives f ! liv]1 :i* may or may n possess !rapeutic virtues4 ,s f> z we "k1 h[ev]1 no satisfactory evid5ce is =?com+ to indicate t su* extractives h any !rapeutic value40 #adg ,fraud & ,deception ,connect$ ) ,s-,call$ ,cod ,liv] ,oil ,prep>ations1 ,! ,j\rnal ,a4 ,m4 ,a41 ,oct4 #ac1 #aijf1 p4 #abjg4 ,x 0 ) prep>ations ( ?is class t our exp]im5ts 7 made4 ,f\r ( ! m ext5sively adv]tis$ br&s 7 select$1 z !y repres5t r di/9ct types ( ?is class ( products1 z ! foll[+ claims ( _! label w %[3 ,hagee's ,cordial ( ! ,extract ( ,cod ,liv] ,oil1 ,comp\nd4--8,tonic1 /imulant1 alt]ative1 recon/ructive1 nutritive & dige/ive40 8,ea* fluid ounce repres5ts ! extract obta9able f #a_/c fluid ounce ( cod liv] oil 7! fatty portion be+ elim9at$71 #f grs4 calcium hypophosphite1 #c grs4 sodium hypophosphite1 #a_/b gr4 salicylic acid 7made f oil w9t]gre571 ) glyc]9 & aromatics40 ,v9ol4--8,! mod]n tonic recon/ructor conta9+ ! m$ic9al extractives ( fre% cod liv]s ) peptonate ( iron40 8,:5 ! blood is poor1 :5 m fre% blood is ne$$1 :5 ! weak ne$ /r5g?1 :5 ! ?roat & lungs are affect$1 ,,take ,,v9ol40 ,wampole's ,p]fect$ & ,ta/eless ,prep>ation ( an ,extract ( ,cod ,liv]4--8,conta9s a solution ( an extractive obta9able f fre% cod liv]s1 ! oily or fatty portion be+ aft]w>d elim9at$4 ,?is extractive is comb9$ ) liquid extract ( malt1 fluid extract ( wild *]ry & comp\nd syrup ( hypophosphites 7conta9+ calcium1 sodium1 potassium1 iron1 manganese1 qu99e & /ry*n9e740 ,wat]bury's ,comp\nd1 ,pla94--8,made f cod liv] oil1 dige/ive f]m5ts1 malt extract unf]m5t$1 hypophosphites comp4 special1 ext4 *]ry1 eucalyptus1 aromatics1 etc40 ,?us we h repres5t$ 9 our exp]im5ts an 8extract0 ) hypophosphites1 "o ) peptonate ( iron1 "o ) malt extract & hypophosphites & ! alkaloids qu99 & /ry*n91 & "o ) malt extract & hypophosphites )\t alkaloids4 ,9 ord] to prep>e a dry ration ( suitable keep+ prop]ties1 x 0 necess>y to remove ! alcohol & wat] f ! v>i\s prep>ations4 ,?is 0 done by evaporation "u r$uc$ pressure at f #dj to #ee ,c4 7#ajd to #aca ,f474 ,9 ! case ( ,hagee's ,cordial x 0 claim$ t "o fluid\nce ( ! prep>ation repres5t$ #a_/c fluid\nce ( cod liv] oil1 & 9 ! subsequ5t sub/itution = cod liv] oil 9 our rations1 ?is ratio 0 us$ = all f\r products4444 ,^! are v dissimil> prep>ations1 ! alcohol rang+ f #g4ej to #ah4fi p] c5t41 ! extract f #h4gb to #ci4ec p] c5t4 7#aj4ha ( ! #ac4ah gm4 ( extract 9 ,hagee's ,cordial be+ glyc]971 ! a% f #j4cje to #a4ifg p] c5t41 ! r$uc+ sug>s f #a4ce to #ag4aj p] c5t41 & ! glyc]9 f a trace to #aj4ha p] c5t4 ,wampole's conta9$ qu99 & /ry*n91 ! o!rs no alkaloids2 salicylates 7 pres5t 9 all b ,wampole's2 sac*>9 9 ,hagee's4 ,! ,pett5k(f] te/ = bili>y acids gave a negative result 9 ,hagee's & ,wampole's2 9 ,v9ol & ,wat]bury's1 small am\nts ( fatty acids 7 obta9$1 am\nt+ to #j4jaf & #j4jcb gm4 p] hundr$ c4c41 respectively1 q insignificant am\nts4 ,! fe$+ exp]im5ts 7 made on alb9o rats ( bo? sexes1 :i* 7 plac$1 :5 ab\t #f weeks old1 on a /&>d ration1 ,no4 #g1 & aft] sev]al mon?s1 :5 a failure to ma9ta9 weight 0 indicat$1#adh an am\nt ( dealcoholiz$ cordial extract equival5t to #ah p] c5t4 ( cod liv] oil 0 sub/itut$ = a portion ( ! l>d1 ! cordial extract lat] be+ replac$ by an equival5t am\nt ( cod liv] oil4 #adh ,osborne & ,m5del h %[n 7,j\r4 ,biol4 ,*em41 #aiac1 xv1 #caa7 t mixtures ( purifi$ prote91 l>d1 />* & prote9-free milk h be5 s+ul>ly effici5t = a "t 9 promot+ gr[? ( "y rats4 ,9 f sixty to #ajj days or m1 h[ev]1 normal gr[? /ops2 ! animals may rema9 at con/ant weight = a few days1 or gr[ v sl[ly1 & !n sudd5ly decl9e & die unless a *ange is made 9 ! diet4 ,! sub/itution ( butt]-fat1 egg yolk fat1 or cod liv] oil = a portion ( ! l>d 9 ! ration1 9 ! exp]im5ts ( ^! au?orities1 br\ght prompt recov]y & cont9uation ( normal gr[?4 ,,summ>y ,table #aa gives a summ>y ( ! actual ga9s ( ! fifte5 rats on ! f\r rations1 comp>$ ) ! ga9s %[n by cod liv] oil & ^? %[n by normal rats at ! same p]iod ( _! life hi/ory4 ,,table #aa4--,,summ>y ,,( ,,results,,bk ,total ,total ,av]age ,av]age ,rations ,normal ,actual ,normal ,actual ,ga91 ,ga91 ,ga91 ,ga91 ,gm4 ,gm4 ,gm4 ,gm4 ---------------------------------------- --------------- ,hagee ration #bd -#cf4b #f -#i4a ,cod liv] oil ration #aad #aef4d #bh4e #ci4a ,v9ol ration #db -#a4e #aj4e -#j4d ,cod liv] oil ration #db #hg4e #aj4e #ba4i ,wampole ration #hc #ea4d #bj4h #ab4i ,cod liv] oil ration #fb #ha4e #ae4e #bj4d ,wat]bury ration #cb #j4c #aj4g #j4a ,cod liv] oil ration #db #hg4d #ad #bi4a ---------------------------------------- --------------- ,,bk ,9 ?is table are giv5 ! totals & av]ages ( ! figures already pres5t$ 9 ,tables #d1 #f1 #h & #aj4 ,9 consid]+ ! effect ( ^! prep>ations z g5]al m$ic9es1 _! alcohol cont5t mu/ n be ov]look$4 ,hagee's ,cordial conta9s #g4ej p] c5t4 ( alcohol by volume1 ,v9ol #ah4fj p] c5t41 ,wampole's ,prep>ation #af4ei p] c5t41 & ,wat]bury's ,comp\nd #aa4be p] c5t4 ,full /r5g? :isky conta9s #ej p] c5t4 ( alcohol by volume4 ,by foll[+ ! doses prescrib$ by ! manufactur]s ( ^! prep>ations1 ! us] w\ld consume daily ! foll[+ equival5ts ( full /r5g? :isky3 ,9 ,hagee's ,cordial #j4bd fluid\nce ,9 ,v9ol #j4h fluid\nce ,9 ,wampole's ,prep>ation #j4g fluid\nce ,9 ,wat]bury's ,comp\nd #j4f fluid\nce ,^! am\nts ( alcohol are by no means negligible & d\btless expla9 to a consid]able ext5t ! s\rce ( ! alleg$ tonic virtues ( ^! prep>ations4 ,! results ( ! exp]im5ts may be summ>iz$ z foll[s3 ,hagee's ,cordial fail$ to su/a9 rats dur+ p]iods ( sev5 & f\rte5 days1 ! rats %[+ a loss 9 weight ( #cf4b gm41 in/ead ( ! normal ga9 ( #bd gm4 ,v9ol 9 two cases su/a9$ & 9 two cases fail$ to su/a9 gr[? dur+ p]iods ( f elev5 to ?irty-five days1 ! net loss 9 weight ( ! f\r rats be+ #a4e gm41 in/ead ( ! normal ga9 ( #db gm4 ,wampole's ,prep>ation 9 ?ree ,cases su/a9$ & 9 "o case promot$ gr[? 9 rats dur+ p]iods ( eighte5 & ?irty-n9e days1 %[+1 h[ev]1 only #ea4d gm4 ga9 9 weight in/ead ( ! normal #hc gm4 ,wat]bury's ,comp\nd 9 two cases su/a9$ & 9 "o case fail$ to su/a9 rats dur+ p]iods ( f\rte5 & ?irty days1 ! net ga9 9 weight1 h[ev]1 be+ b #j4c gm4 in/ead ( ! normal #cb gm4 ,cod liv] oil %[$ a ga9 ( #db4d gm4 ov] ! normal1 :ile ) ! same rats ,hagee's ,cordial %[$ a loss ( #fj4b gm4 ,cod liv] oil %[$ a ga9 ( #de4e gm4 ov] ! normal1 :ile ) ! same rats ,v9ol %[$ a net loss ( #dc4e gm4 ,cod liv] oil %[$ a ga9 ( #ai4e gm4 ov] ! normal1 :ile ) ! same rats ,wampole's ,prep>ation %[$ a loss ( #ca4f gm4 ,cod liv] oil %[$ a ga9 ( #de4d gm4 ov] ! normal1 :ile ) ! same rats ,wat]bury's ,comp\nd %[$ a net loss ( #ca4g gm4 ,n only did cod liv] oil %[ a m>k$ sup]iority z a s\rce ( nutrim5t ov] ,hagee's ,cordial1 ,v9ol1 ,wampole's ,prep>ation & ,wat]bury's ,comp\nd1 b x also %[$ a rem>kable recon/ructive & recup]ative p[] 9 its ability to enable rats to ga9 weight rapidly & /eadily aft] hav+ suff]$ f a defici5cy 9 nutrim5t :5 f$ ! f\r prep>ations nam$ above4--7,abbreviat$ f ,! ,j\rnal ,a4 ,m4 ,a41 ,feb4 #bj1 #aiae47 ,,diabetic ,,foods ,,(f]$ ,,= ,,sale ,,9 ,,! ,,unit$ ,,/ates ,a ,prelim9>y ,report ,john ,phillips ,/reet1 ,m4,s4 ,*emi/1 ,connecticut ,agricultural ,exp]im5t ,/ation ,,new ,,hav51 ,,conn4 ,rec5t ref]5ces 9 ,! ,j\rnal to glut5 fl\rs & c]ta9 o!r foods (f]$ = ! use ( diabetics sugge/ t a prelim9>y report ( an inve/igation j ab\t complet$ 9 my laboratory by ,pr(4 ,l4 ,b4 ,m5del & myself might be useful to _m diabetics & to physicians :o are call$ on to arrange _! diet>ies4 ,9 #aijf ?is laboratory1 !n "u ! direction ( ,dr4 ,a4 ,l4 ,w9ton1 :o is n[ ) ! ,dep>tm5t ( ,agriculture1 made its fir/ exam9ation ( comm]cial diabetic foods4 ,9 ne>ly e ye> s9ce x has analyz$ v>i\s o!r br&s z !y appe>$ on ! m>ket4 ,! dem& = ! reports on ^! foods & ! _m inquiries direct$ to u h l$ u to make a m ext5sive review ( ! situation1 & to collect z f> z possible all in=mation z to ! quality ( ! s-call$ 8diabetic0 foods (f]$ to ! ,am]ican public4 ,t ! pres5t /ate ( ! m>ket is unsatisfactory is well kn[n1 & ! inf]iority 7f ! diabetic's po9t ( view7 ( _m ( ! products at pres5t (f]$ is un=tunately famili> to all c>eful dietitians4 ,! mo/ dang]\s feature ( ! pres5t situation is t ! unsuspect+ pati5t is l$ to pur*ase foods1 g5]ally at an exorbitant price1 :i* are n only misrepres5t$ b :i* may be positively h>mful to him4 ,9 ?is day ( self-m$ication ?is condition is all ! great] m5ace to ! diabetic4 ,)\t any attempt to sugge/ me?ods ( treatm5t = diabetes1 :i* is ! prov9ce ( ! physician1 ,i may say t x is well recogniz$ t diabetes is prim>ily a di/urbance ( nutrition1 9 :i* ! normal ability ( ! body to make use ( c>bohydrates is m or less completely impair$4 ,all rec5t au?orities agree 9 plac+ ! *ief emphasis on ! role ( diet 9 ! managem5t ( ?is disease4 ,janeway1 ,b5$ict1 ,josl91 ,fut*]1 ,falta1 ,/rauss1 von ,noord5 & o!r writ]s on diabetes c\ld be quot$ at l5g? 9 support ( ?is view4 ,! importance ( a re/riction ( ! c>bohydrates 9 c]ta9 cases & c]ta9 aspects ( diabetes is admitt$ by practically all compet5t au?orities4 ,9 ord] to prescribe a />*-free & sug>-free diet>y1 :i* at times is necess>y1 & to "k accurately ! actual am\nt ( ^! c>bohydrates conta9$ 9 ! v>i\s available foods1 ! physician mu/ rely on ! coop]ation ( ! *emi/ to furni% ?is requisite in=mation4 ,?is is our excuse1 if any be ne$$1 = our pres5t inve/igation4 ,!re seems to be "s unc]ta9ty z to :at sort ( prep>ation is entitl$ to be sold z a 8diabetic0 food4 ,grant+ ! desirability ( fe$+ ! pati5t all ! c>bohydrate he c tol]ate1 & recogniz+ ! possible value ( ! oatmeal1 potato1 rice & o!r treatm5ts1 9 :i* a relative abundance ( c>bohydrate is f$ = a limit$ p]iod1 x w\ld seem t a l[ p]c5tage ( c>bohydrates %\ld be a requisite = a 8diabetic0 food4 ,c]ta9ly no special food conta9+ ne>ly z mu* c>bohydrate z a normal food ( ! same class %\ld be entitl$ to ?is appellation4 ,fl\rs1 breads1 biscuits1 *ocolates1 breakfa/-foods1 mac>oni1 etc41 conta9+ only a slightly l[]$ p]c5tage ( c>bohydrates1 are no m entitl$ to be call$ 8diabetic0 foods ?an ! normal foods !mselves4 ,x is true t1 :5 a pati5t's c>bohydrate tol]ance is well e/abli%$1 ! use ( foods conta9+ #bj1 #be & ev5 #ce p] c5t4 ( c>bohydrates might be p]missible1 :5 us$ "u ! direction ( a compet5t physician2 b :5 a /rict diet is necess>y1 su* z is requir$ to det]m9e ?is tol]ance1 ev5 ^! relatively l[ p]c5tages are objectionable1 if n dang]\s4 ,x has be5 our purpose to include 9 ?is inve/igation1 z ne>ly z possible1 all available data on ! composition ( all diabetic foods sold 9 ,am]ica4 ,our report1 !re=e1 w be 9 "p compil$1 b 9 great] "p w consi/ ( our orig9al analyses4 ,x w %[ #eci analyses ( ab\t #djj br&s1 #bjj ( :i* are our own new analyses & #aaj ^? made 9 ?is laboratory 9 previ\s ye>s4 ,:ile ! purpose ( ?is prelim9>y note is to call att5tion to ! bett] prep>ations r ?an to emphasize ^? :i* are obvi\sly objectionable & fraudul5t1 x may n be out ( place to summ>ize briefly our f9d+s 9 g5]al4 ,! full details ( ! inve/igation are n[ be+ prep>$ = publication & w %ortly be issu$ z a report f ! ,connecticut ,agricultural ,exp]im5t ,/ation4 ,"o hundr$ & eight samples ( sixty-eight br&s ( fl\rs & meals are includ$ 9 ! report4 ,sixty-sev5 ( ^! 7 sold z 8glut50 fl\rs1 tw5ty ( :i* did n ev5 satisfy ! l[ gov]nm5t /&>d ( #ce p] c5t4 prote94 ,twelve samples conta9$ less ?an #ac p] c5t4 c>bohydrates1 :ile ! rema9+ glut5 fl\rs rang$ f #bh to #gf p] c5t4 ,! soy bean fl\rs conta9$ f #bc to #bf p] c5t4 ( c>bohydrates1 ! almond meals #ag p] c5t41 & a cotton-se$ fl\r #ba p] c5t4 ,o!r 8diabetic0 fl\rs1 n specifically sold z 8glut50 fl\rs1 conta9$ f #fg to #hj p] c5t4 ,! pur*as] ( glut5 fl\rs at ! pres5t "t may obta9 prep>ations conta9+ f #hg to #aa p] c5t4 ( prote9 & f #d to #gf p] c5t4 ( c>bohydrates1 at a co/ ( f #i c5ts to #a4ef p] p\nd4 ,9 view ( ! gov]nm5t's l[ /&>d = glut5 fl\r1 & because ( ! wide v>iations 9 composition f\nd 9 ! br&s at pres5t on ! m>ket1 prop] protection ( ! diabetic dem&s t ! manufactur]s ( ^! fl\rs %\ld be requir$ to /ate on ! label ! gu>ante$ p]c5tages ( bo? prote9 & c>bohydrates4 ,?ree samples ( ,am]ican s(t glut5 breads conta9$ f #ce to #cg p] c5t4 ( c>bohydrates2 two o!r br&s conta9$ #di & #ed p] c5t41 little1 if any1 l[] ?an f\nd 9 ord9>y :eat bread4 ,"o hundr$ & =ty-eight analyses ( #aab br&s ( h>d breads1 biscuits1 rusks1 cakes & o!r bak]y products are includ$4 ,eight br&s ( ,luftbrot1 or a]at$ bread1 are report$2 two ( ^! conta9$ f #i to #ab p] c5t4 ( c>bohydrates1 "o #bj p] c5t41 two f #ca to #cc1 & ! o!r ?ree f #dd to #ed p] c5t4 ,a numb] ( ! br&s ( rolls1 biscuits1 breads1 etc41 %[$ satisfactorily l[ p]c5tages ( c>bohydrates1 ?irty-five samples conta9+ f #a to #be p] c5t41 =ty-f\r samples conta9+ f #ce to #ee p] c5t41 & =ty-"o ov] #ee p] c5t41 sev5 ( ! latt] exce$+ #gb p] c5t4 ,! co/ ( ! ,luft breads rang$ f #ga c5ts to #b4cc p] p\nd4 ,biscuits1 conta9+ #aa p] c5t4 or less ( c>bohydrates1 co/ f #gb c5ts to #c p] p\nd4 ,a numb] ( br&s1 conta9+ f #dc to #gg p] c5t41 co/ f #c to #c4fj p] p\nd4 ,ev5 ! *eap] prep>ations1 conta9+ f #ej to #gg p] c5t41 no bett]1 & 9 "s cases ev5 worse1 = ! diabetic's use ?an ord9>y bread1 co/ f #cj to #da c5ts p] p\nd4 ,f\rte5 samples ( breakfa/-foods 7 analyz$1 five ( :i* conta9$ f #dd to #ed p] c5t4 ( c>bohydrates1 some:at l[] p]c5tages ?an normal4 ,sev5 ( ! t5 br&s ( recomm5d$ mac>oni1 noodles1 etc41 conta9$ ov] #gj p] c5t4 ( c>bohydrates1 ! o!r ?ree f #db to #ea p] c5t4 ,! analyses are giv5 ( f\rte5 samples ( peanut butt]1 five ( almond pa/e & butt]1 two ( p9e-nuts1 "o ( almonds & t5 ( miscellane\s nut foods4 ,z 0 to be expect$1 mo/ ( ^! prep>ations prov$ to be suitable diabetic foods4 ,! peanut butt]s conta9$ f #ab to #bj p] c5t4 ( c>bohydrates1 ) an av]age ( #ae p] c5t4 ,! ?ree almond pa/es conta9$ f #cj to #dj p] c5t41 "o %[+ an addition ( #aa p] c5t4 corn/>*4 ,! two almond butt]s conta9$ only #g & #h p] c5t41 ! p9e-nuts f #c to #h p] c5t41 & ! almonds #af p] c5t4 ,! o!r nut prep>ations conta9$ f #f to #dd p] c5t4 c>bohydrates4 ,sev5 br&s ( diabetic *ocolates conta9$ f #aj to #ej p] c5t4 c>bohydrates1 :ile f\r cocoas conta9$ f #ba to #ea p] c5t4 ,! *ocolates co/ f #a4fc to #b4jf p] p\nd1 & ! cocoas 7 simil>ly exp5sive4 ,two sug>-free milks 7 exam9$ :i* 7 true to "n1 conta9+ only ! m]e/ traces ( c>bohydrates4 ,"o 8diabetic0 bak+-p[d] exam9$ conta9$ no />*1 ano!r br& f #ad to #af p] c5t4 ,v>i\s jams1 pres]ves & o!r fruit products 7 exam9$ :i* conta9$ f #a4bd to #g p] c5t4 ( inv]t sug>1 p]c5tages f> bel[ ! normal4 ,a currant-juice conta9$ only #j4he p] c5t4 ( inv]t sug>4 ,f\r ( ! fruit prep>ations 7 artificially color$ ) a coal-t> dye--a p]mitt$ color to be sure1 b seem+ly q out ( place 9 foods int5d$ prim>ily = ! use ( invalids4 ,z already /at$1 ! ma9 purpose ( ?is inve/igation 0 n s mu* to detect fraud z to secure in=mation :i* w\ld be ( b5efit to ! diabetic & to ! physician :o seeks foods suitable = a l[ c>bohydrate diet4 ,9 ! accompany+ tabulations a summ>y is giv5 ( ! br&s1 sold z diabetic foods1 :i* %[$ less ?an #ce p] c5t4 ( c>bohydrates1 arrang$ 9 ! ord] ( _! c>bohydrate#adi cont5t4 ,a date 9 p>5!ses foll[+ a br& "n signifies t ! br& nam$ %[$ v>iations 9 diff]5t ye>s2 9 o!r cases1 9 :i* ! agreem5t 0 close1 ! results h be5 av]ag$4 #adi ,9 ! tables 8c>bohydrates0 is us$ z synonym\s ) 8nitrog5-free extract40 ,,br&s ,,%[+ ,,"u #e ,,p] ,,c5t4 ,,( ,,c>bohydrates ,p] ,c5t4 ,casoid ,bak+ ,p[d] 4#j ,dr4 ,b\ma ,sug>-,free ,fat-,milk 4#j ,:it+'s ,sug>-,free ,milk 4#j ,rademann's ,currant ,juice 8ohne ,zuck]0 #j4i ,kal>ia ,batons 7#aiji7 #j4i ,glid9e #a4j ,casoid ,sug>less ,m>malade #a4b ,casoid ,sug>less ,jam #a4e ,kal>i ,biscuit #a4g ,casoid ,d9n] ,rolls #b4a ,casoid ,fl\r #b4b ,jireh ,diatetic ,p9e ,nuts #c4d ,rademann's ,pres]v$ ,fruits1 8entzuck]t0 #c4e ,kellogg's ,protose #c4f ,b>k]'s ,glut5 ,food 8,a0 #d4a ,kellogg's ,p9e ,nuts #d4b ,kellogg's #hj ,p] ,c5t4 ,glut5 ,biscuit #d4d ,bis*('s ,glut5 ,fl\r #e4j ,,br&s ,,%[+ ,,f #e ,,to #aj ,,p] ,,c5t4 ,,( ,,c>bohydrates ,p] ,c5t4 ,casoid ,biscuits ,no4 #b #e4f ,rademann's ,pres]v$ ,fruits 89 eig55 ,saft0 #e4g ,b>k]'s ,glut5 ,food 8,b0 #e4i ,kellogg's ,nuttol5e #f4c ,na%ville ,sanit>ium ,nutcysa #f4c ,huntley & ,palm]'s ,akoll ,biscuit #f4e ,na%ville ,sanit>ium ,nutfoda #f4h ,rademann's ,pres]v$ ,fruits 8ohne ,zuck]0 #g4j ,mull]'s ,tomatoes fr ,diabetik] #g4c ,b>k]'s ,glut5 ,food 8,c0 #g4g ,kal>i ,batons 7#aiac7 #g4g ,casoid ,biscuits ,no4 #c #g4h ,kellogg's #hj ,p] ,c5t4 ,glut5 7#aiab7 #g4i ,casoid ,biscuits ,no4 #a #h4j ,kellogg's ,almond ,butt] #h4b ,fromm's ,uni ,bread #i4j ,metcalf's ,vegetable ,glut5 7#aiac7 #i4h ,,br&s ,,%[+ ,,f #aj ,,to #ae ,,p] ,,c5t4 ,,( ,,c>bohydrates ,p] ,c5t4 ,kellogg's ,pure ,glut5 ,biscuit 7#aijf7 #aj4b ,heal? ,food ,pure ,wa%$ ,glut5 ,fl\r 7#aiac7 #aa4a ,heal? ,food ,alpha ,diabetic ,waf]s #aa4c ,loeb's ,import$ ,glut5 ,fl\r #aa4h ,heal? ,food ,no4 #a ,proto ,puffs #aa4i ,kellogg's ,potato ,glut5 ,biscuit 7#aijf1 #aiji7 #aa4i ,kellogg's ,nut ,meal #ab4a ,kellogg's #hj ,p] ,c5t4 ,glut5 7#aiji7 #ab4e ,na%ville ,sanit>ium ,nut ,butt] #ac4j ,kellogg's ,nut ,butt] #ac4i ,bis*('s ,diabetic ,glut5 ,bread #ad4c ,jireh ,diabetic ,bak+ ,p[d] #ae4j ,peanut ,butt] 7range f #ab to #bj7 #ae4j ,,br&s ,,%[+ ,,f #ae ,,to #bj ,,p] ,,c5t4 ,,( ,,c>bohydrates ,p] ,c5t4 ,casoid ,*ocolate ,almonds #af4a ,cali=nia ,pap] ,%ell ,almonds #af4c ,call>d's ,cocoanut ,biscuit #af4d ,rademann's ,diabetik]-,*okolade #af4i ,heal? ,food ,almond ,meal #af4i ,call>d's ,g+] ,biscuit #ah4a ,call>d's ,prolactic ,biscuit #ai4c ,,br&s ,,%[+ ,,f #bj ,,to #be ,,p] ,,c5t4 ,,( ,,c>bohydrates ,p] ,c5t4 ,call>d's ,almond ,%ortbreads #bj4g ,call>d's ,casoid ,rusks #bj4h ,rademann's ,diabetik]-,makron5 #bj4h ,heal? ,food ,protosoy ,diabetic ,waf]s #ba4b ,jireh ,pat5t ,cotton-,se$ ,fl\r #ba4c ,casoid ,lun* ,biscuit #ba4f ,rademann's ,diabetik]-,*okolade ,biscuit #ba4i ,c]eo ,soy ,bean ,gruel ,fl\r #bc4g ,heal? ,food ,salvia ,/icks #bd4j ,heal? ,food ,protosoy ,soy ,fl\r #bd4e ,metcalf's ,soja ,bean ,meal #be4j ,,br&s ,,%[+ ,,f #be ,,to #ce ,,p] ,,c5t4 ,,( ,,c>bohydrates ,p] ,c5t4 ,jireh ,soja ,bean ,meal #be4h ,brusson ,*ocolat ) ,add$ ,glut5 #bf4d ,rademann's ,diabetik]-,/ang5 #bg4j ,rademann's ,diabetik]-,dess]t-,gebck #bg4e ,na%ville ,sanit>ium ,malt$ ,nut ,food #bg4e ,metcalf's ,vegetable ,glut5 7#aijf7 #bh4a ,heal? ,food ,pure ,wa%$ ,glut5 ,fl\r 7#aijf7 #bi4e ,fromm's ,luft ,bread #cj4g ,sp5c]'s ,almond ,pa/e #ca4f ,fromm's ,conglut9-,diabetik]-,s*okolade #cb4g ,heal? ,food ,no4 #b ,proto ,puffs #cc4c ,f]buson ,glut5 ,bread #cc4f ,gum ,glut5 ,breakfa/ ,food #cd4b --7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,june #bh1 #aiac47 ,,! ,,jireh ,,diabetic ,,food ,,company ,! ,company ,rises to ,expla9 9 a ,brief ,note ( ,"o ,?\s& ,words ,exploit]s ( fraudul5t & dang]\s ph>maceutical products h no love = ,! ,j\rnal4 ,:5 su* products are expos$ 9 ^! pages1 _! manufactur]s seldom reply to ! criticisms except ?r\gh indirect *annels4 ,!n ! replies are frequ5tly replete ) bill+sgate & d5unciation ( ,! ,j\rnal & its editor1 ! ,association & ! m$ical pr(ession g5]ally4 ,we h1 at diff]5t times1 _h to call ! att5tion ( ! public & ! m$ical pr(ession to ! fraudul5ce & dang]s ( "s ( ! products ( ! ,jireh ,diabetic ,food ,company4 ,we h %[n t ! ,jireh company li$ boldly & directly s long z x c\ld d s )\t gett+ into ! c\rts1 & t x lies inf]5tially /ill2 we h %[n t ,jireh fl\r _h practically z mu* c>bohydrate z ord9>y fl\r2 we h %[n t1 probably to escape prosecution "u ! ,food & ,drugs ,act1 ! ,jireh conc]n has co9$ ! ^w 8diatetic0 & sub/itut$ x = ! ^w 8diabetic10 :i* us$ to appe> 9 its adv]tisem5ts2 we h %[n t ! claim made = ! ,jireh products t !y are 8/>*-*ang$0 0 a false "o1 & t ! company has modifi$ ?is to 8/>*-treat$10 presumably to avoid be+ hal$ into ! c\rts "u ! 8pure food law20 we h %[n1 9 %ort1 ! unreliability bo? ( ! ,jireh conc]n & ( its products4 ,two or ?ree weeks ago a ,new ,york physician wrote to ,! ,j\rnal = in=mation reg>d+ ! ,jireh products4 ,we s5t him su* matt] z _h be5 publi%$ on ! subject1 & he %[$ ?is mat]ial to a pati5t :o 0 us+ ! ,jireh products4 ,! pati5t1 9 turn1 express$ h] op9ion ( ! product to ! retail] f :om %e _h be5 pur*as+ x4 ,a day or two lat] %e receiv$ a lett] f ! ,jireh ,diabetic ,food ,company1 :i*1 9 spite ( its l5g? & discursiv5ess1 we publi% 9 full1 s t physicians may "k j :at ?is company ?9ks ( !m4 ,! lett]1 :i* is dat$ ,nov4 #bj1 #aiac1 really belongs 9 ! 8,knocks & ,boo/s0 dep>tm5t1 b its l5g? prev5ts its use !re4 ,"h x is3 8,we le>n$ ?r\gh ,mess4 ,cu%man ,co4 t y are a con/ant us] ( ,jireh ,foods = "s "t pa/1 & t rec5tly a c]ta9 d]ogatory /atem5t 0 br\ght to y\r att5tion relative to our product4 ,we feel an explanation is due y = two reasons4 8,fir/1 because we want y to cont9ue us+ ,jireh ,foods & ?us receive ! b5efits ( ! same2 & second1 t ! rem>ks call$ to y\r att5tion are n only libel\s1 b are 9 no way p]t95t en\gh to detract f ! value ( our product4 ,9 ! fir/ place1 we want to /ate t ! p>ticul> j\rnal 9 "q has be5 endeavor+ to injure our bus9ess = "s "t pa/ & t we are n ! only desc5t sic manufactur]s ( foods t are suff]+ 9 ?is way at ! h&s ( ! editors ( ?is p>ticul> magaz9e4 ,s9ce y are int]e/$ 9 ! ,jireh ,foods1 y may be m int]e/$ to le>n :y ?is p>ticul> magaz9e is s anxi\s to injure our reputation4 ,! reason is v obvi\s if y w take into acc\nt ! fact t ?is magaz9e is ! (ficial j\rnal ( ! m$ical association ( ?is c\ntry :i* is kn[n z ! back] ( ! m$ical tru/4 ,x is v cle> to y1 no d\bt1 t !re are "s physicians1 p>ticul>ly ^? t are associat$ ) ! magaz9e1 :o are anxi\s to /amp out ( exi/ance sic su* conc]ns t (f] a bona fide product1 a m]itori\s product :i* actually produces ! requir$ results1 )\t ! aid ( m$ic9e4 8,= ! p>ticul> maladies = :i* we (f] our foods1 we h be5 v successful1 consequ5tly ! antagonism on ! "p ( ?is p>ticul> j\rnal is ! logical ?+4 ,9 addition to ?is1 h[ev]1 & p]haps m important to u1 is ! fact t ! editors ( ?is magaz9e h made x kn[n to u t !y w n approve ( our product until su* "t t we c>e to be dom9at$ by ! mov+ influ5ce ( ! magaz9e 9 "q4 ,!y want u to supply !m ) ! private =mula :i* we use = manufactur+ our foods & to enlight5 !m & %[ !m ! v>i\s processes appli$ to our products to produce ! requir$ results4 ,z a bona fide & e?ical bus9ess h\se1 we absolutely & unqualifi$ly refuse to comply ) ?is wi%1 & w always refuse to d s1 no matt] h[ (t5 !y may attack u4 ,we /& /rictly on pr9ciple 9 ?is matt] & propose to run our bus9ess 9 our own way1 & w n1 "u any circum/ances1 all[ a magaz9e or anybody else dictate to u "u :at conditions we are all[$ to d our bus9ess4 8,! rem>ks :i* !y make w\ld p]haps hurt u "s if !y emanat$ f a s\rce t 0 qualifi$ to judge ! m]its ( our food4 ,! absurd side ( ! issue1 & p]haps ! comical side ( x1 is ! fact t ! honorable g5tlem5 :o assume to condemn a product1 "k less ab\t ! disease = :i* ! product is (f]$1 & mu* less ab\t diet & foods ?an ! av]age layman4 ,consequ5tly1 we consid] x simply absurd to all[ !m to /ep into our bus9ess & dictate policy to u4 ,?is is ! ji/ sic ( ! discont5t t prevails betwe5 ! magaz9e editors & ourselves1 & z long z we refuse to comply ) _! wi%1 we c]ta9ly _c expect !m to speak well ( u4 ,x has become a notori\s fact 9 ! m$ical pr(ession t _! criticisms are almo/ valueless1 inasmu* z !y /op at no?+ 9 ord] to create s5sationalism1 & h attack$ n only ourselves1 b e bona fide manufactur] ( foods & drugs 9 ?is c\ntry :o has refus$ to fall 9 l9e ) !m4 8,?is explanation1 we tru/1 w appeal to y\r good judgm5t & w conv9ce y ( :at is said ab\t u is untrue4 ,fur!rmore1 our bus9ess has gr[n to colossal proportions1 not)/&+ _! endeavors to cru% u4 ,we call y\r att5tion to a mo/ peculi> fact3 t is1 t !y make no comm5t :atsoev] z to ! product & its !rapeutic value 9 ! treatm5t ( diabetes4 ,y notice !y make an awful play on our lit]ature1 :i* 0 *ang$ m]ely to suit conditions 9 bus9ess4 ,we also wi% to call y\r att5tion to ano!r peculi> fact1 & t is t a great majority ( ! physicians :o are 9 ) ?is magaz9e readily recomm5d$ our foods1 & we also believe t y\r physician1 aft] read+ ?is lett]1 w feel ! same way z mo/ physicians d 9 relation to our foods4 ,we believe t y\r physician is p]fectly will+ to be conv9c$ t our foods are z repres5t$ to be1 & ! v be/ cl9ical evid5ce z ?is is ! effect our foods h _h ^u y4 ,f9ally1 if ! foods are palatable & :olesome & h alleviat$ ! annoy+ symptoms ( ,diabetes1 !n :y %\ld y be guid$ by ! op9ions ( demagogues & yell[ j\rnali/s8 8,y may be pleas$ to le>n t our foods h receiv$ ! att5tion ( ,dr4 ,wiley1 ! well-kn[n *emi/ & food sci5ti/ ( ?is c\ntry1 & we h n[ 9 our possession 8 reports %[+ ! v high /&>d ( our foods4 ,?is1 9 our op9ion1 is ( m consequ5ce ?an all ! h>angue :i* ^? v5]able g5tlem5 ( ! magaz9e may indulge 94 8,we want to conv9ce y )\t an atom ( d\bt t we are hone/ & bona fide 9 ev]y?+ we say1 & we ext5d to y a he>ty invitation to call at ! fir/ opportunity & %all be glad to tell y any?+ y may wi% to "k4 ,?us await+ ! pleasure ( ?is visit1 we beg to rema9 8,y\rs v truly1 8,jireh ,diabetic ,food ,co40 ,we le>n f ?is lett] t ,! ,j\rnal's 8rem>ks0 on ! ,jireh product are 8libel\s40 ,we h made !m _m times & = sev]al ye>s pa/2 if libel\s1 ! manufactur] has excell5t gr\nds = damages4 ,we le>n1 too1 t our rem>ks 8are 9 no way p]t95t en\gh to detract f ! value0 ( ! ,jireh products4 ,:y1 !n1 take any notice ( !m8 ,we le>n1 moreov]1 = ! hundr$-&-fir/ "t1 t ,! ,j\rnal is ! (ficial organ ( ! 8m$ical tru/10 & we are told t 8!re are "s physicians0 t are oppos$ to ! ,jireh ,foods because ^! products cure diabetes )\t ! use ( m$ic9e6 ,! ,j\rnal1 s ! company says1 wants ! ,jireh ,diabetic ,food ,company to supply its 8private =mula0 & to %[ ! 8v>i\s processes0 by :i* ! ,jireh products are made4 ,su* /atem5ts indicate t ! ,jireh ,diabetic ,food ,company does n conf9e its m5dacity to ! m]e adv]tis+ ( its product1 :]e ! necessity = ly+ is naturally great4 ,! ambigu\s rem>ks reg>d+ ,dr4 ,wiley are evid5tly int5d$ to convey ! idea t ! doctor approves ( ! ,jireh products4 ,dr4 ,wiley 0 s5t a copy ( ! ,jireh lett] & 8 att5tion direct$ to ! /atem5ts appe>+ !re9 reg>d+ himself4 ,he repli$3 8,9 reg>d to ! ,jireh products & _! claims t our reports %[ ! v high /&+ ( _! foods1 ,i w\ld say t ,i consid] su* a claim entirely false4444 ,we did exam9e five or six products 9 our own laboratory1 h[ev]1 & f\nd !m to be ( v fair composition p] se1 b n ( a composition t af=d$ any legitimate basis = _! claims4 ,we entirely disapprov$ 444 ?ree ( ! products mak+ special claim z to _! fitness = diabetics4 ,italics ours4--,ed4 ,^! 7 ! ,:eat ,nuts1 ! ,jireh ,fl\r & ! ,pat5t ,b>ley4 ,two ( ! o!r products 7 pass$ ) a non-committal rat+1 :i* means t !y are n actually disapprov$1 b ! /> m>k+ is n accord$4 ,^! products 7 ! dietetic ,rusks & ! ,mac>oni4 ,= ! latt] especially no specific claims seem to be made4 ,we call$ att5tion1 h[ev]1 to ! g5]ally objectionable juggl+ ( t]ms indulg$ 9 by ?is company44440 ,! ,jireh conc]n says t 9 spite ( ! ef=ts ( ,! ,j\rnal to 8cru%0 x1 8our bus9ess has gr[n to colossal proportions40 ,( ?is ! ,new ,york physician :o s5ds u ! lett] says3 8,_! #8colossal proportions' mu/ h receiv$ a slight j> or !y w\ld n h tak5 "t to write su* a lett]40--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,dec4 #bj1 #aiac47 ,,! ,,"n 8,,ep9ephr90 ,,v]sus ,,! ,,"n 8,,adr5al90,,bl ,,bl ,a repr9t ( ! lett] f ,p>ke1 ,davis ,co4 ref]r$ to 9 ?is article1 toge!r ) ! discussion !re(1 w be s5t on receipt ( a #b-;c5t /amp4 ,!re are ?irty or m diff]5t br&s ( ! blood-pressure-rais+ pr9ciple ( ! supr>5al gl& on ! m>ket1 five be+ 9 ?is c\ntry alone4 ,^! products are id5tical s f> z _! *ief con/itu5t is conc]n$2 !y diff]1 h[ev] z to ! solv5t & pres]vative us$4 ,! processes ( manufacture ( "s ( !m are pat5t$2 all ( !m are sold "u trade names4 ,until two ye>s ago !re 0 no common "n applicable to ?is active pr9ciple2 :5ev] ref]5ce 0 made to x a trade "n _h to be us$4 ,at t "t ! ,c\ncil on ,ph>macy & ,*emi/ry1 realiz+ ! ne$ ( a g5]ic t]m1 adopt$ 8ep9ephr90 z su* a t]m4 ,?is "n 0 select$ 9 "p because ,abel _h adopt$ x 9 #ahii2 9 "p because1 s f> z c\ld be discov]$1 x 0 ! "n "u :i*1 ?r\gh ,abel's publications1 ! sub/ance fir/ appe>$ 9 m$ical lit]ature2 & 9 "p because x seem$ to be ! only suitable "o n already appropriat$ by "s comm]cial firm4 ,aft] ! publication ( ! ,c\ncil's report1 ,! ,j\rnal began gradually to use ! t]m 9 ^? cases 9 :i* x seem$ cle> t ! propriet>y t]m 0 us$ 9 a g5]ic s5se4 ,! sub/itution ( ! "n 8ep9ephr90 = 8adr5al90 9 ! ab/racts ( c]ta9 =eign articles caus$ ,p>ke1 ,davis ,co4 to write a lett] ( prote/ :i* call$ =? ! discussion appe>+ 9 ! ,propag&a ,dep>tm5t ( ?is issue4 ,! am\nt ( space devot$ to ?is matt] may be criticiz$ & consid]$ unw>rant$ by ^? :o d n realize ! importance ( ! subject4 ,! criticism is to a c]ta9 degree1 j4 ,! some:at inord9ate l5g? ( ! article is due 9 "p to ! un=tunate fact t1 9 avail+ !mselves ( ! c\rtesy ext5d$ by ,! ,j\rnal1 ,p>ke1 ,davis ,co41 9 _! reply1 h inject$ into ! discussion side-issues1 su* z ! priority ( discov]y1 ! sup]iority ( _! product1 etc41 :]eas ! "q "u discussion is simply t :i* relates to ! "n4 ,x is1 h[ev]1 n altoge!r a matt] = regret t ! discussion has be5 ?us broad5$1 = x br+s be=e our read]s _m facts reg>d+ ! discov]y ( an important m$ic9al ag5t t are n g5]ally kn[n1 at lea/ by physicians4 ,:e!r or n 8adr5al90 is sup]ior to 8adr910 8supr>5al910 8supr>5910 8adnephr910 or to any o!r ( ! prep>ations is entirely immat]ial 9 ?is connection4 ,! po9t is t ! active pr9ciple ( ! supr>5al gl& is on ! m>ket "u v>i\s trade names1 & t a "n common to all has be5 select$ to be us$ :5 no p>ticul> br& is ref]r$ to4 ,! fact t 8adr5al90 is reg>d$ by _m1 bo? "h & abroad1 z a common1 g5]ic "n does n alt] ! fact t x is claim$ z a trade "n by a comm]cial h\se &1 !re=e1 presumably at lea/1 _c be us$ except z su*4 ,among ! facts br\ght out 9 ?is discussion1 "o /&s out cle>ly3 t ,abel des]ves z mu* cr$it = ! discov]y z any o!r man1 if n m4 ,cr$it belongs to ,takam9e = mak+ use ( reactions :i* 7 already well kn[n4 ,8 "w 0 a /ep 9 ! progress ( k ( ! sub/ance1 b x 0 a /ep :i* he c\ld n h tak5 b = :at o!rs1 ,abel especially1 _h accompli%$ & publi%$4 ,abel's magnific5t "w1 cov]+ sev]al ye>s1 des]ves z mu* cr$it1 to say ! lea/1 z t ( ,takam9e4 ,& x %\ld be kept 9 m9d t ! =m] work$ 9 ! int]e/ ( sci5ce1 & publi%$ 8 results = ! b5efit ( all4 ,he _h no hope ( pecuni>y rew>d1 ask$ = none1 & receiv$ none4 ,let u repeat1 h[ev]1 t ^! are side issues2 ! "q is simply t ( "n4 ,x _c be too /rongly emphasiz$ t 8ep9ephr90 is a true sci5tific "n = ! active pr9ciple ( ! supr>5al gl&1 & t x %\ld be us$ on all occasions :5 ! active pr9ciple & n "s p>ticul> firm's make is ref]r$ to4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,m>* #be1 #aiaa47 ,,! ,,hord ,,sanit>ium 8,propag&a = ,re=m ,dep>tm5t3--,"o (t5 he>s x decl>$ t ! pres5t "t is ! wor/ ev] kn[n = a "y man to make a =tune or get a />t to "o4 8,all a mi/ake1 z ! enclos$ lett] f ! ,hord ,sk9at>ium w c]tify4 ,at #be ?is equals #b1ejj = #ajj cases1 #be1jjj = #a1jjj cases1 & all any "y doctor ne$s is a little pu% to be z ri* z ,j4 ,d4 9 a few mon?s4 ,if y "k ( any cases s5d 'em 9 & get y\r #be4 8,k4 ,t4 ,cross51 ,m4,d41 ,c>bondale1 ,ohio40 ,) 8 lett] ,dr4 ,cross5 encloses a circul> lett] f ! ,hord ,sanit>ium1 8,= ,liquor & ,drug ,habits1 ,a ,cure ,positively ,gu>ante$10 & an unsign$ *eck on ! ,f>m]s ,national ,bank1 ,%elbyville1 ,indiana1 = #be payable to himself4 ,pr9t$ on ! *eck 9 l>ge r$ lett]s is ! /atem5t3 8,,?is ,,*eck ,,w ,,be ,,c\nt]sign$ ,,^u ,,y ,,br++ ,,or ,,s5d+ ,,u ,a ,,pati5t40 ,illu/ration3 ,fig4 #a4--,photographic reproduction ( ! unsign$ *eck t ! ,hord ,sanit>ium s5ds to physicians4 ,illu/ration3 ,fig4 #b4--,"p ( ! lett] t accompanies ! *eck = tw5ty-five doll>s4 ,! ,j\rnal has receiv$ ^! circul> lett]s & unsign$ *ecks by ! hundr$s f physicians :o h express$ v frankly _! contempt ( ! k9d ( bus9ess ! ,hord ,sanit>ium is engag$ 94 ,^! correspond5ts seem to h ov]look$ ! fact t ,! ,j\rnal has already comm5t$ editorially on ?is p>ticul> insult to ! m$ical pr(ession4 ,= ?is reason we repr9t ! editorial note1 8,e?ics60 f ,! ,j\rnal1 ,sept4 #bg1 #aiac3 8,we w pay y #be = ea* pati5t t y br+ or s5d u40 ,?us1 to physicians1 writes ! ,hord ,sanit>ium ( ,%elbyville1 ,indiana1 & cont9ues3 8,we h a p]fect & an absolute cure = all liquor & drug addictions40 ,fe>+ d\btless t ^? to :om ^! (f]s are made may be disgu/$ ) ! fir/ proposition & w realize ! evid5t falsity ( ! second1 ! conc]n encloses a li/ ( ref]5ces 8%[+ ! high moral & pr(essional /&+ ( our sanit>ium40 ,! ,hord ,sanit>ium emphasizes fur!r t x does a /rictly 8no cure no pay0 bus9ess4 ,suspici\sly simil> is ! (f] made by ! ,miz] ,sanatorium ( ,co%octon1 ,ohio1 ,blake ,v4 ,miz]1 manag]4 ,n _m mon?s ago ,mr4 ,miz] 0 runn+ ! ,hord ,sanitorium 7! conc]n's own spell+71 :i* at t "t adv]tis$ 8! only gu>ante$ cure40 ,n[1 ,mr4 ,miz] hurls invectives at ^? conc]ns t make 8unreasonable gu>antees0 & adds virtu\sly t 8we resort to no su* une?ical & pret5d$ gu>antee 9 ord] to d bus9ess40 ,nev]!less1 9 small type 9 ! nor?we/ corn] ( 8 /ation]y1 ,mr4 ,miz] admits t 8 8proposition0 is no cure no pay4 ,! fees ( ! ,miz] ,sanatorium 8are #abe to #bej1 dep5d+ on ! room40 ,! physician's rake-(f is 8#bj p] c5t4 ( ! above40 8,?is10 expla9s ,mr4 ,miz] bl&ly1 8is simply a matt] betwe5 ourselves & does n conc]n ! pati5t 9 any way40 ,( c\rse n4 ,all ! pati5t has to d is to pay ! bills4 ,& ! ,miz] ,sanatorium is 8conduct$ along e?ical 444 l9es0--,mr4 ,miz] says s4 ,! ,miz] ,sanatorium has odd ideas ( :at con/itutes e?ics1 m$ical or o!rwise1 = n long ago x adv]tis$1 9 su* m$ical j\rnals z w\ld accept its 8copy10 t 8m$ical e?ics prev5ts ! /atem5t "h ( ! :ole tru? ab\t ! ,miz] treatm5t40 ,( c\rse m$ical e?ics nev] prev5t$ tru?ful /atem5ts ( any k9d4 ,a dirty bus9ess2 no o!r words express x4 ,:5 ! ,hord ,sanit>ium & ! ,miz] ,sanatorium claim to cure all cases ( drug or liquor addiction1 !y make claims t are false--cruelly false4 ,:5 ^! conc]ns try to drum up trade by (f]+ secret commissions to physicians !y insult an honorable pr(ession4 ,! fact t !y s5d out ?is sort ( adv]tis+ matt] is presumptive pro( t !re are "s physicians :o w patronize !m4 ,su* z d s are unfair to _! pati5ts & untrue to ! ideals ( m$ic9e4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #ca1 #aiad47 ,,! ,,g]man ,,propag&a ,,= ,,re=m ,appreciation by a ,g]man ,lay ,publication ,( all ^? int]e/$ 9 ! re=m ( ! propriet>y drug bus9ess1 ! pati5t has ! mo/ at /ake--& ! public is beg9n+ to und]/& ?is fact4 ,if physicians are sl[ 9 recogniz+ ! necessity = improvem5t1 laym5 w ev5tually dem& re=m 9 _! own int]e/s4 ,! movem5t1 !re=e1 w n be halt$ by ! indiff]5ce ( ! unprogressive elem5t ( ! m$ical pr(ession4 ,new evid5ce ( ?is fact is furni%$ by a rec5t editorial comm5t by ! ,g]man lay p]iodical1 ,wohlfahrt und ,wirts*aft 7,public ,welf>e & ,economics71 on ! ,arzneimittel-,kommission1 a ,g]man organization resembl+ 9 purpose if n 9 scope ! ,c\ncil on ,ph>macy & ,*emi/ry ( ! ,am]ican ,m$ical ,association4 8,"o w\ld suppose10 says ?is lay j\rnal1 8t m$ic9al prep>ations :i* did n w9 ! approval ( sci5tific m$ic9e w\ld n be us$ by any physician1 b ! contr>y is ! case4 ,9 fact1 ^? new m$ic9al prep>ations or old ones ) new names t flood ! m>ket f> surpass ! actual dem& accord+ to ! judgm5t ( all au?orities4 ,! imp>tial advis]s 9 ?is field1 practition]s & memb]s ( m$ical faculties1 dem&1 z a matt] ( public welf>e t ?is ov]production %\ld be regulat$ 9 ! int]e/s ( ! sick1 ! consum]s2 b1 un=tunately1 a m$ical man1 l any "o else1 is impress$ by ! sugge/ion f adv]tis+ done on a l>ge scale40 ,! movem5t = re=m1 ,wohlfahrt und ,wirts*aft goes on to expla91 is n exclusively a m$ical "o4 ,x is a "p ( ! reaction ( 8economic common s5se0 aga9/ a too individuali/ic comm]cial sy/em :i* leads to ov]production4 ,9 o!r words1 x is a reaction aga9/ ! sy/em ( mak+ ?+s because !y c be sold r ?an because !y are ne$$4 ,! int]e/s ( produc]s ne$ to be h>moniz$ ) ^? ( consum]s1 n m]ely 9 ! drug trade alone1 b ?r\gh\t ! comm]cial _w4 ,wohlfahrt und ,wirts*aft quotes ) unqualifi$ approval ! ,arzneimittel,kommission's /atem5t ( its position3 ,an indu/ry :i* s]ves ! sci5ce ( heal+ mu/ be guid$ by t sci5ce4 7,e9e ,indu/rie die d] ,heilwiss5s*aft di5t1 hat si* na* d] ,heilwiss5s*aft zu ri*t547 ,! movem5t = re=m 9 ,g]many has app>5tly ga!r$ suffici5t impetus among ! laity to g on ( its own mom5tum1 ev5 ?\gh1 ) "o exception1 ,g]man m$ical j\rnals1 reluctant to lose ! adv]tis+ ( drug h\ses by publi%+ criticisms ( _! w>es1 h become lukew>m1 if n antagoni/ic1 to ! ef=ts ( ! ,arzneimittel,kommission4 ,! "o exception is ! ,!rapeutis*e ,monat%efte1 :i*1 9 its ,may issue1 quotes 9 full ! editorial j ref]r$ to & makes ! foll[+ comm5t3 8,^! l9es reveal su* intimate k & correct judgm5t ( exi/+ conditions t ! sugge/ions advanc$ 9 reg>d to possible re=ms des]ve s]i\s consid]ation4 ,= u physicians ! editorial is important 9 t x recognizes t ! ef=ts ( ! pr(ession to accompli% ! re=ms aim$ at are rational & b5eficial f ! /&po9t ( g5]al economics & ! public welf>e40--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,june #ac1 #aiad47 ,,! ,,g]man ,,c\ncil ,,on ,,ph>macy ,,& ,,*emi/ry ,at ! meet+ ( ! ,g]man ,congress = ,int]nal ,m$ic9e 9 #aiaa1 a ,g]man c\ncil on ph>macy & *emi/ry1 ,die ,arzneimittelkommission des ,kongresses fr inn]e ,m$iz91 0 organiz$1 ) purposes simil> to ^? = :i* ! ,c\ncil on ,ph>macy & ,*emi/ry ( ! ,am]ican ,m$ical ,association 0 creat$4 ,z practically no?+ has be5 done to re/rict ! adv]tis+ ( propriet>ies 9 ,g]many1 ! task ( ! commission 0 trem5d\s4 ,its "w has be5 not$ 9 ,! ,j\rnal f "t to "t4#aej ,a review ( :at has be5 done up to ! pres5t is giv5 by ,heubn]1#aea & indicates "s diff]5ces betwe5 conditions 9 ,g]many & ?is c\ntry4 ,! memb]s ( ! commission f\nd confront+ !m ! same evils t met ! e>ly ef=ts ( ! ,am]ican c\ncil1 namely1 dom9ant propriet>y int]e/s1 a subs]vi5t & f9ancially int]e/$ m$ical press & an indiff]5t pr(ession4 ,moreov]1 ! pecuni>y int]e/ ( ! editors ( ,g]man m$ical j\rnals 9 ! pr(its ( adv]tis+ seems to be m direct & m important ?an 9 ,am]ica4 ,! ,g]man commission1 9 ,heubn]'s op9ion1 0 plac$ at a disadvantage comp>$ ) ! ,am]ican c\ncil f ! fir/4 ,funds = inve/igation 7 lack+1 & ! commission _h no j\rnal 9 :i* its objects c\ld be pres5t$ to ! m$ical pr(ession4 ,at ! beg9n+ ( its "w ! commission e/abli%$ rules v simil> to ^? ( ! ,am]ican ,c\ncil on ,ph>macy & ,*emi/ry4 ,x li/$ ! articles adv]tis$ 9 ,g]man m$ical j\rnals 9 ?ree gr\ps3 7#a7 ^? :i* con=m$ to ! rules ( ! commission 9 ! me?od ( adv]tis+2 7#b7 ^? :i* violat$ ! rules1 & 7#c7 ^? ^: classification c\ld n be det]m9$4 ,?is am\nt$ to an attack on adv]tis+ 9 m$ical j\rnals & 0 und\bt$ly premature4 ,x ar\s$ at once ! antagonism n only ( ! propriet>y int]e/s b also ( ! m$ical press4 #aej ,a ,g]man ,c\ncil on ,ph>macy & ,*emi/ry1 ,propag&a1 ,! ,j\rnal ,a4 ,m4 ,a41 ,july #bg1 #aiab1 p4 #bia2 ,curr5t ,comm5t1 ,aug4 #aj1 #aiab1 p4 #deb4 ,re=m 9 ! ,adv]tis+ ( ,propriet>y ,m$ic9al ,articles1 ,b]l9 ,lett]1 ,dec4 #g1 #aiab1 p4 #bjha4 ,heubn]1 ,w43 ,wns*e zur ,re=m des ,arzneiv]triebes1 ,!rap4 ,monat%41 #aiab1 xxvi1 ,no4 #aa2 ab/r41 ,! ,j\rnal ,a4 ,m4 ,a41 ,dec4 #ad1 #aiab1 p4 #baie4 #aea ,heubn]3 ,die ,arzneimittelkommission des deuts*5 ,kongresses fr inn]e ,m$iz91 ,!rap4 ,monat%41 #aiad1 xxviii1 #ahe4 8,! e/abli%m5t ( ! li/s ( m$ic9es enc\nt]$ opposition or h9drance f ?ree s\rces10 says ,heubn]1 8fir/1 f ! ph>maceutical & *emical manufactur+ int]e/s2 second1 f ! m$ical press1 & ?ird1 f ! m$ical pr(ession itself4 ,! #8trade' naturally 0 irritat$ at any attempt to int]f]e ) #8bus9ess1' & br\ght =w>d a numb] ( reasons :y ! proc$ure adopt$ by ! commission 0 especially calculat$ to injure ! #8g5]al welf>e4' ,?is opposition 0 to be expect$ & might be disreg>d$4 ,! ext5t to :i* ! m$ical press 0 dep5d5t on ! drug trade1 h[ev]1 _h n be5 =ese54 ,! same j\rnals 9 :i* = _m ye>s all sorts ( articles on ! evils 9 ! trade 9 m$ic9es _h appe>$ %[$ !mselves decid$ly cool or emphatically critical t[>d ! accompli%$ fact ( ! #8li/s ( rem$ies4' ,9 ha/ily writt5 articles a :ole s]ies ( mi/akes 9 g5]al & 9 p>ticul> 7 publi%$4444 ,"o ?+1 h[ev]1 0 n explicitly /at$--namely1 t 9 any ev5t ! li/s ( rem$ies mu/ be reject$1 & = ?is ! cog5t reason 0 anxiety 9 reg>d to adv]tisem5ts4 ,! editors _h be5 suffici5tly w>n$4 ,! ,!rapeutis*e ,monat%efte1 :i* _h n submitt$ to ! wi% ( a great indu/rial firm 9 ano!r matt]1 0 puni%$ = ?is (f5se by ! )drawal ( all its adv]tisem5ts4 ,none ( ! o!r publi%]s want$ to risk su* a r$uction 9 income1 & none ( ! editors 0 will+ to und]take ! risk to ! ext5t ( a conflict ) 8 publi%]4 ,curi\sly1 ! idea does n seem to h aris5 t if ! ?reat5$ publi%]s _h made common cause !y might h fre$ _! editors f ! di/ress+ burd5 ( improp] adv]tisem5ts ) sc>cely any risk at all40 ,heubn] believes t ano!r motive influ5c+ ! editors 0 ! fact t _! ef=ts 9 behalf ( re=m1 sporadic & ineffective at ! be/1 _h be5 replac$ by ! propag&a ( ! commission4 ,x seems cle> t ! opposition f ! press 0 due n to pr9ciple *iefly b to f9ancial pressure4 ,! editors1 h[ev] unwor?y _! motives1 nev]!less ex]t$1 z 9 o!r cases1 a p[]ful influ5ce on public op9ion4 ,among ! m$ical public1 opposition 0 enc\nt]$ because _m physicians 7 int]e/$--sometimes f9ancially--9 "o or m ( ! discr$it$ rem$ies4 ,! mass ( ! pr(ession ei!r 7 n int]e/$ or misund]/ood ! position ( ! c\ncil4 ,despite ! ob/acles enc\nt]$ & ! difficulties involv$1 ! c\ncil & ! ,congress ( ,int]nal ,m$ic9e h n wav]$4 ,heubn]1 h[ev]1 sums up ! "w ( ! c\ncil 9 a r pessimi/ic tone1 z foll[s3 8,:at are ! results ( ! great am\nt ( labor1 self-sacrifice1 hopeful c\rage & wa/$ money8 ,two j\rnals pret5d to be do+ wond]s 9 t !y are elim9at+ "s ( ! wor/ mis/atem5ts1 di/ortions1 obscurations & concealm5ts ( tru? 9 ! adv]tisem5ts4 ,physicians at c]ta9 int]vals receive li/s ( prep>ations1 ! manufactur]s ( :i* z a rule d n ne$ to pay any att5tion to ! c\ncil because _! deal+s are directly ) ! public1 because _! adv]tisem5ts are usually made to physicians by ^w ( m\?1 or _! prep>ations h already a suffici5t reputation--no matt] = :at reason4444 8,!re is little d\bt t ! results h n paid = ! ef=ts exp5d$4 ,!re is no d\bt t ! :ole ent]prise w am\nt to no?+ m ?an a spla% 9 ! wat] if ! "w is n ext5d$1 j z a prelim9>y skirmi% mu/ rema9 )\t effect unless foll[$ up by ! ma9 army4 ,! ma9 army 9 ?is case is ! ,g]man m$ical pr(ession4 ,h[ev] gratify+ ! progressive attitude ( "s individuals &1 9 fact1 ( "s associations1 su* z t ( ,wurtemburg1 may be1 ! fact rema9s t ! pr(ession 9 ,g]many is n advanc+ b r t5ds to retrograde4 ,! support :i* ! executive committee ( ! ,a]ztev]e9sbund at fir/ accord$ to ! ef=ts ( ! c\ncil 0 lat] limit$4 ,all fur!r progress dep5ds on ! developm5ts ( ! ne> future4 ,w suffici5t p[] be giv5 to ! ,g]man m$ical pr(ession aft] settlem5t ) ! insurance societies to p]mit !m to foll[ ! example ( _! ,am]ican colleagues8 8,x %\ld be made p]fectly cle>10 ,heubn] insi/s1 8t we are conc]n$ ) que/ions ( importance = ! /&+ & influ5ce ( ! m$ical pr(ession among ! p1 &1 consequ5tly1 = ! conditions ( its future exi/5ce4 ,b ev5 n[ ! consequ5ces ( ! prevail+ indiff]5ce to ! traffic 9 no/rums are mak+ !mselves felt4 ,! preval5ce ( self-m$ication1 :i* 0 lately recogniz$ by a ,b]l9 c\rt z ! normal = #8slight' affections & :i* has already be5 made an argum5t aga9/ ! ext5sion ( ! compulsory prescription law1 is m]ely a result ( ! great evil bas$ on ! loss ( control by ! m$ical pr(ession ( ! rem$ies x employs4 ,only c5traliz$ & en]getic measures on ! "p ( ! organiz$ pr(ession c secure a re=mation ( ! intol]able conditions t prevail 9 ! field ( mod]n indu/ry 9 m$ic9e & food/uffs4 ,! ,am]ican ,m$ical ,association & ! ,g]man ,arzneimittelkommission h %[n t a little sacrifice & en]gy c secure a condition 9 :i* ! m$ical pr(ession becomes a p[]ful factor1 able to dictate 9 ! field ( ! trade 9 m$ic9e in/ead ( lett+ itself be dictat$ to40--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,april #ah1 #aiad47 ,,gr& ,,prix ,,& ,,gold ,,m$als ,,= ,,sale ,max ,kais] ,(f]s to ,procure 8,aw>ds ( ,m]it0 at ,v>i\s ,int]national ,exhibitions--,price1 ,f\r ,hundr$ ,doll>s ,!re 0 a "t :5 ! manufactur] :o c\ld po9t to ! 8,gr& ,prix0 or ! 8,gold ,m$al0 8 product _h be5 aw>d$ at "s exhibition 0 consid]$ to h a valuable adv]tis+ asset4 ,possibly !re 0 a "t :5 m$als & prizes 7 aw>d$ ) an eye s+le to ! excell5cies ( ! goods & bore no relation to ! am\nt ( money paid by exhibitors to ! organiz]s ( ! exhibition4 ,possibly !re are1 ev5 today1 occasional aw>ds made on a basis ( pure m]it1 b !y are probably few & f> betwe54 ,! matt] :i* foll[s ?r[s an int]e/+ light on ?is subject4 ,)9 ! pa/ two mon?s manufactur]s h receiv$ a lett] on ! /ation]y ( ! 8,int]national ,exhibition1 ,p>is1 #aiad40 ,! lett] came f ! 8,commission]-,g5]al0 ( ! exhibition1 "o ,max ,kais]1 #bd ,holborn1 ,london1 ,e4 ,c4 ,"h x is3 8,de> ,sirs3--,i beg to draw y\r att5tion to ! great ,,int]national ,,exhibition ( ,alim5tation1 ,pure ,food1 ,hygi5e1 ,bev]ages1 ,drugs & alli$ trades1 :i* w be held at ,p>is 9 ,m>*1 #aiad1 invit+ y to p>take ) y\r manufacture at ?is ,,int]national ,,exhibit4 ,i beg to po9t out t ! aim ( ?is ,exhibition is to introduce ,=eign ,manufactur$ ,goods1 ,propriet>y ,articles1 ,pat5ts1 etc41 to ! ,fr5* & ,=eign ,m>kets1 & to op5 up or ext5d new *annels = su* goods4 8,a ,comm]cial ,(fice at ! ,exhibition ,build+1 "u ! ,commission] ,g5]al's own sup]vision1 ) a well-tra9$ /aff1 w d ev]y?+ requir$ 9 ! int]e/ ( ,exhibitors1 su* z effect sales by circul>iz+1 or invit+ prom95t buy]s to call at y\r p>ticul> /all to judge = !mselves ! m]its ( y\r ,exhibit1 & 9 ?is way br+ ! ,am]ican ,manufactur]s 9 direct t\* ) ! ,=eign ,m>kets & ! ,buy+ ,public4 8,?is ,comm]cial ,(fice w also negotiate ) ! ,repres5tatives on y\r behalf3 at ! same "t und]tak+ to arrange y\r ,exhibit1 supply all necess>y fitt+s1 decoration1 ! display1 ma9t5ance1 repack+ & return+ ( ! ,exhibit1 & also to repres5t y be=e ! ,public & ,jury 9 su* a mann] z to make c]ta9 t y\r ,exhibit %all be aw>d$ fir/ honors 7,,gr& ,,prize ,,or ,,gold ,,m$al74 8,y w und]/& t su* an aw>d obta9$ at ?is ,,int]national ,,exhibition means an ev]la/+ adv]tisem5t z an (ficial ackn[l$gm5t & conv9c+ pro( to ! ,sup]ior ,quality ( y\r goods1 & w c]ta9ly put y 9 front ( y\r competitors on ! home m>ket1 & naturally increase y\r sales consid]ably4 8,i might m5tion "h t _m a big bus9ess has be5 built up & small conc]ns be5 prom95tly br\ght to ! notice ( ! ,public by ,exhibit+4 ,9 _m cases ,i h be5 able to int]e/ ,au?orities & ,reign+ ,h\ses 9 ,exhibits "u my c>e1 & ,i h op5$ up or ext5d$ m>kets = firms ,exhibit+ "u my direction4 8,i enclose h]e) a li/ conta9+ "s ( ! mo/ prom95t ,am]ican & ,engli% ,firms :om ,i h repres5t$ at ,european ,exhibitions & = :om ,i a*iev$ spl5did results4 8,i c\ld arrange y\r ,exhibit = ! am\nt ( #djj1 to be paid "o-half on allotm5t & ! balance on receipt ( an aw>d 7,gr& ,prize or ,gold ,m$al74 8,tru/+ t ?is w be ( int]e/ to y1 ,i %all be pleas$ to receive y\r reply by return mail1 & give y any fur!r p>ticul>s y may desire4 ,y\rs fai?fully1 ,! ,commission] ,g5]al4 7,sign$7 ,max ,kais]4 8,i c also accept ,exhibits on exactly ! same t]ms = ! ,,int]national ,,exhibition1 ,rome1 #aiad40 ,illu/ration3 ,photographic reproduction 7r$uc$7 ( ! lett]-head ( ! /ation]y on :i* ,max ,kais] (f]s to 8make c]ta90 t ^? :o exhibit _! products "u 8 direction--price1 #djj--%all receive a ,gr& ,prix or ,gold ,m$al4 ,! li/ ,mr4 ,kais] enclos$ ) 8 lett] 0 a pr9t$ %eet1 giv+ ! names ( a numb] ( ,am]ican & ,briti% manufactur]s :om ,kais] claims to h 8repres5t$0 at v>i\s 8,int]national ,exhibitions40 ,! majority ( ! conc]ns nam$ are brew]ies1 b !re is a good spr9kl+ ( 8pat5t m$ic9e0 companies & a few miscellane\s manufactur]s4 ,9 ! ,am]ican li/ !re are two no/rum conc]ns nam$ t w be m or less famili> to our read]s4 ,!y are3 ,alonzo ,o4 ,bliss ,company1 ,wa%+ton1 ,d4 ,c4 ,?is company sells 8! ,great ,blood ,purifi]1 ,kidney & ,liv] ,regulator0 kn[n z 8,bliss' ,native ,h]bs40 ,accord+ to ,max ,kais]1 ! ,alonzo ,o4 ,bliss ,company obta9$ "o ,gr& ,prize & "o ,gold ,m$al4 ,wat]bury ,*emical ,company1 ,des ,mo9es1 ,i[a4 ,?is company exploits :at us$ to be kn[n z 8,wat]bury's ,cod-,liv] ,oil ,comp\nd10 :i*1 f its lack ( cod-liv] oil1#aeb 0 impell$ to *ange its "n to 8,wat]bury's ,comp\nd40 ,kais] /ates t ! ,wat]bury ,*emical ,company receiv$ f\r ,gr& ,prix & f\r ,gold ,m$als4 #aeb ,see ,wat]bury's ,comp\nd1 pp4 #ed1 #eg & #bia4 ,briefly ! proposition submitt$ by ,max ,kais] is ?is3 ,= #djj he w make all arrangem5ts = a manufactur]s' exhibit at "o ( ! num]\s 8,int]national ,exhibitions40 ,fur!r1 he practically gu>antees t ?is exhibit w receive ei!r a 8gr& prize0 or a 8gold m$al02 9 fact1 ! manufactur] ne$ n complete ! paym5t ( ,kais]'s *>ges until ! prize or m$al has be5 aw>d$6 ,! value ( 8aw>ds0 obta9$ 9 ?is way is1 ( c\rse1 evid5t4 ,z ! public becomes bett] in=m$ on ! subject ( int]national exhibitions1 ! gr& prix1 gold m$als1 & o!r 8aw>ds0 made at su* exhibitions w be apprais$ at _! true value4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,m>* #ad1 #aiad47 ,,! ,,hypophosphite ,,fallacy ,an ,example ( ! ,p]petuation ( a ,false ,!ory by ,adv]tis+ ,a false !rapeutic notion born ( speculation soon dies a natural dea? if expos$ unsupport$ to ! cold _w ( facts1 b :5 nurs$ by comm]cial int]e/s x may be kept alive = g5]ations4 ,int]e/+ examples ( ?is1 to "n b two or ?ree1 are ! misconceptions p]petuat$ dur+ ! pa/ half c5tury conc]n+ 8li?ia10 ! 8natural0 salicylates & ! hypophosphites4 ,take1 = in/ance1 ! li?ia delusion4 ,! suppos$ solv5t p[]s ( li?ium comp\nds = uric acid 7 soon disprov$ to ! satisfaction ( sci5ti/s1 b proprietors ( li?ia wat]s & no/rums = g\t & rheumatism /ill h>p on ! old /r+ & utilize long-explod$ !ories4 ,take1 aga91 ! alleg$ sup]iority ( 8natural0 to 8syn!tic0 salicylates4 ,9 spite ( exp]im5tal pro( to ! contr>y1 propriet>y int]e/s h be5 able = tw5ty ye>s to p]suade a l>ge "p ( ! m$ical pr(ession t ! effects ( pure salicylic acid made artificially diff] f ! effects ( ! same sub/ance obta9$ f natural s\rces4 ,! altoge!r undes]v$ cont9u$ popul>ity ( hypophosphites af=ds a /rik+ example ( ! influ5ce ( adv]tis+ 9 p]petuat+ !rapeutic error1 = hypophosphites are giv5 on a !ory long s9ce disprov$4 ,x may be int]e/+ to trace ! orig9 & hi/ory ( ! !ory on :i* ! practice ( prescrib+ ! hypophosphites is f\nd$4 ,! e>ly "p ( ! la/ c5tury 0 prolific 9 *emical discov]ies1 &1 z a coroll>y1 9 *emical !ories ( disease4 ,_m ( ! !ories arose f ! ha/y application ( ! *emical prop]ties ( new elem5ts & comp\nds to ! explanation ( ! processes 9 ! liv+ body1 )\t due consid]ation ( ! conditions prevail+ 9 ! animal organism4 ,,! ,,elem5t ,,phosphorus ,! elem5t phosphorus is eag] = oxyg5 & readily oxidizable4 ,:5 tak5 into ! sy/em x acts z a viol5t poison1 &1 9 view ( ?is1 x 0 at fir/ suppos$--al?\gh ! supposition 0 bas$ on no sci5tific data--t x w\ld prove to be a p[]ful !rapeutic ag5t :5 giv5 9 m9ute doses4 ,9 its elem5t>y =m1 phosphorus is difficult to h&le1 & !re=e n conv5i5t = use4 ,h5ce x 0 natural t a comp\nd %\ld be s\ght :i* c\ld be us$ z a sub/itute = ! elem5t4 ,broadly speak+1 phosphorus =ms ?ree classes ( salts v>y+ 9 ! degree ( oxidation3 ! phosphates1 conta9+ ! mo/ oxyg51 ! phosphites1 conta9+ less1 & ! hypophosphites1 lea/ ( ! ?ree4 ,! phosphates1 be+ saturat$ ) oxyg51 und]go little *ange 9 ! body1 & because ( ?is 7 ?\ght to be ( little value 9 !rapeutics4 ,! phosphites conta9 less oxyg51 are un/able & are n us$ 9 m$ic9e4 ,! hypophosphites1 conta9+ /ill less oxyg51 /& ne>e/ to elem5t>y phosphorus & are easily decompos$ & readily oxidiz$ to phosphates4 ,h5ce ! !ory t ! hypophosphites w\ld furni% an admirable s\rce f :i* to obta9 ! action ( ! elem5t phosphorus4 ,,*ur*ill',s ,,!ory ,! hypophosphites 7 introduc$ into m$ic9e ab\t #ahee1 z a sub/itute = elem5t>y phosphorus by a ,dr4 ,*ur*ill ( ,p>is1 & lat] ( ,london1 :o advocat$ _! use z a specific rem$y = consumption4 ,*ur*ill conceiv$ ! !ory t ph?isis is caus$ by a lack ( oxyg5 9 ! tissues2 he !re=e s\ght an ag5t capable ( increas+ oxidation4 ,he 0 l$ to ! use ( hypophosphites = ?is purpose on ! supposition t phosphorus exi/s 9 ! organism z a biologic elem5t 9 a l[] degree ( oxidation ?an ! phosphate4 ,he suppos$ t ?is =m ( phosphorus acts by its *emical aff9ity z an initiatory ag5t 9 attract+ & utiliz+ ! inspir$ oxyg54 ,he believ$ t :5 ?is =m ( phosphorus1 :i* he call$ ! 8phosphide elem5t10 is defici5t 9 quantity 7because x _h be5 oxidiz$ into phosphate1 or because ! supply f natural s\rces 0 defici5t71 ! degree ( oxidation ( ! tissues is less ?an normal4 ,!re=e he advocat$ ! use ( hypophosphites to supply ! lack+ oxidiz+ con/itu5t4 ,he believ$ ?is 8phosphide elem5t0 n only to be ess5tial = ! oxidation ( ! tissues1 b also to be ! s\rce ( en]gy ( ! n]v\s sy/em4 ,,! ,,facts ,! !ory 0 a pretty "o2 ! facts1 h[ev]1 did n support x4 ,subsequ5t inve/igations indicate t in/ead ( consumption be+ due to a lack ( oxyg51 !re is 9 t disease really an increas$ oxidation2 9 o!r words1 ! respiratory ex*anges 9 ?is disease are exagg]at$4 ,! exi/5ce 9 ! sy/em ( a =m ( phosphorus less highly oxidiz$ ?an ! phosphates is unprov$4 ,no evid5ce has be5 produc$ to %[ t phosphorus acts z an en]giz] ( oxidation4 ,!re is no pro( t ! hypophosphites ent] into g5]al metabolism or affect disease processes 9 any way4 ,n only is !re no sci5tific evid5ce = ! utility ( ! hypophosphites1 b sci5ce has long s9ce demon/rat$ _! wor?lessness4 ,9 #ahie ,bodda]t#aec publi%$ rese>*es %[+ t hypophosphites are rapidly elim9at$ ?r\gh ! kidneys un*ang$4 ,simil> results h be5 rea*$ by ,paquel9 & ,joly1 :o attribut$ to ! hypophosphites only ! action ( diuretics4 ,9 #aija ,massol & ,gamel#aed f\nd by animal exp]im5tation t ! hypophosphites did n act z diuretics1 b t ! hypophosphor\s acid 0 completely elim9at$ 9 ! =m ( sodium hypophosphite4 ,! urea 0 n increas$ & ! relation ( urea to total nitrog5 rema9$ ! same4 ,_! results indicat$ no increase ( oxidiz+ actions )9 ! sy/em4 ,f9ally1 ,massol & ,gamel exam9$ ! ur9e ( pati5ts tak+ hypophosphites & f\nd ! same conditions3 ! results 7 ! same z 9 ! exp]im5ts on animals4 #aec ,bodda]t3 ,ar*4 de ph>macod41 #ahie1 #b4 #aed ,massol & ,gamel3 ,j\r4 de ph>m4 et de *em41 #aija1 xiv1 #ccg4 ,,propriet>y ,,!rapeutics ,9 spite ( ^! facts ! hypophosphites cont9ue to be employ$ by _m practition]s4 ,:y8 ,because ! !ory1 be+ plausible at ! "t :5 su* *emical !ories 7 popul>1 ga9$ a c]ta9 recognition & 0 accept$ )\t sci5tific inve/igation4 ,?us ! hypophosphites came into use4 ,x 0 n long be=e !y 7 tak5 up by c]ta9 manufactur]s1 & ! !ory on :i* _! use 0 bas$ became a comm]cial asset4 ,z a result ! !ory1 :i* uncomm]cializ$ w\ld h di$ ( inanition1 0 kept alive by cont9u$ adv]tisem5t4 ,! manufactur] ( propriet>ies hav+ settl$ on a plausible !ory on :i* to sell 8 products has no fur!r ne$ = sci5ce4 ,?us1 :ile ^! !ories are no long] to be f\nd 9 accr$it$ text-books1 !y are /ill prea*$ by ! propriet>y int]e/s4 ,an elaborate pamphlet on 8,iod9e & ,phosphorus10 conta9+ /atem5ts :i* are kn[n to be false1 is "o firm's text-book suppli$ to physicians to-day1 & conta9s long quotations f ,dr4 ,*ur*ill's writ+s ( sixty ye>s ago4 ,?is book conta9s no intimation t ^! !ories h be5 ov]?r[n4 ,x is poor economy to wa/e money 9 *ang+ lit]ature :5 ! old !ories & ! old plausible reason+ w sell goods j z well4 ,consequ5tly ! old errors are drumm$ into ^? physicians :o are will+ to read _! physiology f ! neat monographs ( propriet>y lit]ature & to sit at ! feet ( glib salesm5 :o exp\nd to !m ! propriet>y !ory ( !rapeutics4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,april #be1 #aiad47 ,,buffalo ,,li?ia ,,wat] ,conta9s ,"o-,fif? z ,mu* ,li?ium z ,potomac ,riv] ,wat] ,"s ye>s ago1 ,alex&] ,haig evolv$ ! !ory t mo/ diseases are due to uric acid4 ,! data on :i* he f\nd$ 8 !ory 7 n corroborat$ by sci5tific m51 & inve/igation %[$ t 8 me?ods 7 unreliable4 ,9 spite ( ! fact t ,haig's !ories are utt]ly discr$it$1 & h be5 = ye>s1 ! uric acid fallacy /ill p]si/s1 al?\gh x is n[ l>gely conf9$ to ! public4 ,%rewd bus9ess m51 especially ^? :o are m int5t on mak+ money ?an !y are conc]n$ ) ! mann] 9 :i* t money is made1 owe mu* to ,haig's !ory4 ,z a bus9ess proposition1 uric acid has be5 "o ( ! be/-pay+ fallacies on ! m>ket--& possibly /ill is4 ,x is only necess>y to ref] to ,! ,j\rnal's rec5t article#aee on ! ,turnock mail-ord] m$ical fraud to emphasize ?is fact4 #aee ,! ,j\rnal ,a4 ,m4 ,a41 ,may #bc1 #aiad1 p4 #afge4 ,illu/ration3 ,%[+ h[ 8,buffalo ,li?ia ,wat]0 9 ! c\rse ( "t became 8,buffalo ,li?ia ,spr+s ,wat]40 ,! gov]nm5t has %[n t1 to obta9 a !rapeutic dose ( li?ium f ,buffalo ,li?ia ,spr+s ,wat]1 x w\ld be necess>y to dr9k #bjj1jjj gallons ( ! wat]4 ,! gov]nm5t also decl>$ t ,potomac ,riv] wat] conta9$ five times z mu* li?ium z does ,buffalo ,li?ia ,spr+s ,wat]4 ,contempor>y )1 & to a c]ta9 ext5t a coroll>y (1 ! uric acid fallacy 0 ano!r1 viz41 t li?ium w\ld elim9ate uric acid4 ,?is at once gave a good work+ pr9ciple = ! propriet>y m54 ,uric acid1 we 7 told1 causes disease2 li?ium1 we 7 also told1 w\ld elim9ate uric acid2 !re=e1 li?ium is ! new elixir ( life6 ,c\ld any?+ be simpl]8 ,accept+ ?is !ory1 x 0 inevitable t m9]al wat]s conta9+ li?ium salts %\ld become highly popul>4 ,_m exploit]s ( m9]al wat]s began to place mo/ emphasis on ! li?ium salts 9 _! wat]s ev5 9 ^? cases 9 :i* li?ium 0 pres5t 9 su* inf9itesimal am\nts z to r5d] its detection impossible by any b spectroscopic me?ods4 ,"o ( ! be/ kn[n1 because mo/ widely adv]tis$1 ( ! s-call$ li?ia wat]s is ,buffalo ,li?ia ,wat]--or :at us$ to be call$ ,buffalo ,li?ia ,wat]4 ,aft] ! ,f$]al ,food & ,drugs ,act came into effect1 by :i* falsification on ! label 0 p5aliz$1 ! "n ( ,buffalo ,li?ia ,wat] 0 *ang$ to ,buffalo ,li?ia ,spr+s ,wat]4 ,! reason = ?is *ange 0 t :5 ,buffalo ,li?ia ,wat] 0 subject$ to exam9ation by ! gov]nm5t *emi/s x 0 f\nd to conta9 s little li?ium t ! am\nt pres5t 0 unweighable--x c\ld be demon/rat$ only by ! spectroscope4 ,x 0 evid5tly1 !re=e1 n a li?ia wat] 9 t x did n conta9--at lea/ 9 quantities t c\ld be consum$--an am\nt ( li?ium t w\ld give ! !rapeutic effects ( li?ium3 ,possibly ! company imag9$ t by *ang+ ! "n f 8,buffalo ,li?ia ,wat]0 to 8,buffalo ,li?ia ,spr+s ,wat]0 x _h clev]ly evad$ ! f$]al law4 ,_! argum5t 0 to ?is effect3 ,! spr+s f :i* ?is wat] is tak5 are kn[n z ,buffalo ,li?ia ,spr+s2 !re=e1 x is n a mis/atem5t ( facts to call ?is ,buffalo ,li?ia ,spr+s ,wat]4 ,,:at ,,is ,a ,,li?ia ,,wat]8 ,! ,supreme ,c\rt ( ! ,di/rict ( ,columbia1 hold+ a di/rict c\rt1 has rec5tly giv5 an op9ion on ! ,buffalo ,li?ia ,spr+s ,wat] case4 ,! f9d+s ( ! c\rt are refre%+ly simple1 & *>act]iz$ by t broad commons5se view t is becom+ increas+ly m common among mod]n juri/s4 ,read ,judge ,g\ld's op9ion z to :at con/itutes a li?ia wat]3 8,speak+ g5]ally1 & z an individual ( av]age intellig5ce & in=mation1 x w\ld seem t if "o 7 (f]$ a wat] :i* ! v5dor told him 0 a #8li?ia' wat]1 "o w\ld h ! "r to expect en\gh li?ium 9 ! wat] to ju/ify its *>act]ization z su*1 ?us diff]5tiat+ x f ord9>y potable wat]2 & ?is am\nt w\ld reasonably be expect$ to h "s effect on ! consum] ( ! wat] by reason ( ! pres5ce ( ! li?ium40 ,c]ta9ly a reasonable attitude1 & "o :i* ! man 9 ! /reet n only c und]/& b w agree )4 ,!n came ! "q z to ! actual li?ium cont5t ( ,buffalo ,li?ia ,spr+s ,wat]1 & ! c\rt said3 8,= a p]son to obta9 a !rapeutic dose ( li?ium by dr9k+ ,buffalo ,li?ia ,wat] he w\ld h to dr9k f "o hundr$ & fifty ?\s& to two hundr$ & tw5ty-five ?\s& gallons ( wat] p] day4 ,x 0 fur!r te/ifi$1 )\t contradiction1 t ,potomac ,riv] wat] conta9s five times z mu* li?ium p] gallon z ! wat] 9 controv]sy40 ,,"s ,,te/imonials ,"h1 !n1 is a wat] t has = ye>s be5 adv]tis$ fir/1 9 m$ical j\rnals1 & lat]1 9 lay publications1 z a 8li?ia wat]0 yet1 actually1 x conta9s less li?ium1 five to "o1 ?an is to be f\nd 9 ord9>y riv] wat]4 ,?is is a po9t = physicians to pond] well ov]4 ,turn to ! back volumes ( m$ical j\rnals & read1 bo? 9 ! adv]tis+ & read+ pages1 ! elaborate te/imonials1 giv5 by m5 high 9 ! m$ical pr(ession1 on ! m>vel\s effects obta9$ by ! use ( ,buffalo ,li?ia ,wat]4 ,read ! foll[+ 9 light ( ! fact t ! wat] f ! ,potomac ,riv] conta9s five times z mu* li?ium z ,buffalo ,li?ia ,wat]3 8,9 ! class ( cases 9 :i* li?ia1 soda & pota% are reg>d$ z mo/ specially indicat$1 ,i h obta9$ f> bett] results f ! ,buffalo ,li?ia ,wat]s ?an f any ( ! prep>ations ( ! li?ium salts ( ! ,ph>macopeia40 7,/atem5t by a memb] ( ! ,faculty ( ,m$ic9e ( ,p>is1 ,france1 etc47 8,its ,buffalo ,li?ia ,wat] !rapeutic effects1 9 my practice1 h be5 va/ly sup]ior to ^? obta9$ f ,li?ia ,tablets or o!r ,li?ia prep>ations40 7,/atem5t by an ex-presid5t ( ! ,univ]sity ,college ( ,m$ic9e1 ,ri*mond1 ,va41 etc47 8,x ,buffalo ,li?ia ,wat] is /rik+ly sup]ior to em]g5cy solutions ( li?ia tablets & pure wat]1 ev5 :]e ! said solution is an exce$+ly /rong "o40 7,/atem5t by a =m] ,pr(essor ( ,cl9ical ,m$ic9e ( ! ,college ( ,physicians & ,surgeons1 ,new ,york1 & vice-presid5t ( ! ,am]ican ,m$ical ,association1 etc47 8,:5 ,li?ia is indicat$1 ,i prescribe ,buffalo ,li?ia ,wat] 9 pref]5ce to ! ,salts ( ,li?ia1 because x is !rapeutically sup]ior to laboratory prep>ations ( ,li?ia40 7,/atem5t by a =m] pr(essor 9 ! ,m$ical ,college ( ,virg9ia & ex-presid5t ( ! ,m$ical ,society ( ,virg9ia1 etc47 8,buffalo ,li?ia ,wat] 444 by its ri*ness ( composition ( ,li?ia1 is ( m>vel\s efficacy1 9 cases ( g\t1 ( *ronic1 articul>1 & muscul> rheumatism 4440 etc4 7,/atem5t by =m] ,physician 9 ,ord9>y to ! ,pope2 ,memb] ( ,academy ( ,rome1 etc47 8,i h tri$ c>bonate ( li?ia dissolv$ 9 wat] 9 v>i\s proportions2 b x c]ta9ly does n h ! same effect z ,buffalo ,li?ia ,wat]40 7,/atem5t by a =m] ,surgeon-,g5]al ( ! ,u4 ,s4 ,army1 etc47 ,^! are b a few ( _m te/imonials f physicians t might be quot$4 ,!y are int]e/+ f _m po9ts ( view4 ,!y %[ ! wor?lessness ( te/imony ( ?is sort--no matt] f :at s\rce--& ! fallacy ( t bas$ on s-call$ cl9ical evid5ce4 ,to g back to ! c\rt's f9d+s3 ,9 ! case ( ! gov]nm5t aga9/ ,buffalo ,li?ia ,spr+s ,wat]1 "o o!r judicial op9ion is wor?y ( att5tion1 t ref]r+ to ! attempt on ! "p ( ! exploit]s ( ! wat] to circumv5t1 on a te*nicality1 ! evid5t int5t ( ! ,food & ,drugs ,act4 ,said ,judge ,g\ld3 8,! argum5t seems to be t if ,buffalo ,li?ia ,spr+s are falsely nam$1 be+ call$ #8,li?ia' ,spr+s1 :5 !y d n fl[ wat] conta9+ li?ium1 !re=e ! proprietors h ! "r to sell ! product z be+ ,buffalo ,li?ia ,spr+s ,wat]1 ?us p]petuat+ on ! public ! misnom] connect$ ) ! orig9 ( ! wat]4 ,x is n app>5t h[ ! deceit practic$ on ! public by ! label is mitigat$ by c>ry+ x back to ! designation ( ! spr+ f :i* ! wat] comes40 ,= ye>s no "o1 app>5tly1 ev] criticiz$ ! claims made = ?is product4 ,f9ally1 we got ! ,food & ,drugs ,act & ! f$]al (ficials1 act+ "u ! au?ority ve/$ 9 !m by t law1 9 ,decemb]1 #aiaj1 decl>$ ,buffalo ,li?ia ,wat] misbr&$4 ,?us ?is old e/abli%$ ve/$ int]e/ 0 attack$4 ,! company1 ( c\rse1 f\ght4 ,x fir/ demurr$ to ! *>ge br\ght1 & 9 ,april1 #aiab1 ! demurr] 0 su/a9$4 ,at ! same "t an am5d$ libel 0 fil$ by ! gov]nm5t1 :i* ! company aga9 demurr$ to4 ,?is demurr] 0 ov]rul$ 9 ,june1 #aiab1 :]eon ! company 9 ,decemb]1 #aiab1 fil$ an answ] d5y+ t ! wat] 0 misbr&$4 ,! "q has n[ 7#aiad7 be5 f9ally decid$ by ! c\rt sitt+ z a jury1 ! matt] hav+ be5 submitt$ by agreem5t to ! c\rt4 ,buffalo ,li?ia ,wat] has be5 sold s9ce #ahgh4 ,dur+ ?is p]iod und\bt$ly _m physicians h prescrib$ enorm\s quantities ( ?is wat]1 & _m m laym5 h tak5 ! wat] on _! own initiative1 bas$ on ! adv]tis$ claims made = x4 ,practically all :o pur*as$ ! wat]1 :e!r directly or on ! advice ( physicians1 did s 9 ! belief t !y 7 gett+ li?ium4 ,_h !y kn[n t1 to get a !rapeutic dose ( li?ium !y w\ld h _h to dr9k #bjj1jjj gallons ( ,buffalo ,li?ia ,wat]1 !y w\ld h felt1 & rightly s1 t !y 7 ! victims ( an exp5sive hoax4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,june #ac1 #aiad47 ,,meat ,,extracts ,,& ,,meat ,,juices,,bm ,_! ,composition & ,relative ,values ,,bm ,see ,report ( ! ,c\ncil on ,ph>macy & ,*emi/ry on 8,meat & ,beef ,juices10 p4 #abc4 ,! ,bureau ( ,*emi/ry ( ! ,dep>tm5t ( ,agriculture has rec5tly giv5 9 ,bullet9 ,no4 #aad mu* new & valuable data reg>d+ ! comm]cial meat products4 ,! "w conta9$ 9 ?is bullet9 is practically an elaboration or cont9uation ( t publi%$ 9 ,! ,j\rnal ( ,may #aa1 #aijg1 p4 #afab4 ,x 0 tak5 up to det]m9e ! condition & quality ( meat prep>ations 9 g5]al & f ! results obta9$ to prep>e t5tative /&>ds = ! prep>ation & composition ( su* meat prep>ations4 ,! results z well z ! me?ods ( analysis ( _m meat products are giv51 %[+ ! composition & relative value ( ! v>i\s prep>ations4 ,! comm5ts ( _m inve/igators reg>d+ ! food value ( su* products is also a valuable contribution to ! k ( meat extracts1 & w help 9 decid+ ! real value ( ! prep>ations4 ,! prep>ations tak5 up are divid$ into ?ree g5]al classes 7#a7 ,solid & ,fluid ,meat ,extracts2 7#b7 ,meat ,juices2 7#c7 ,miscellane\s ,prep>ations4 ,= ea* ( ^! ! t5tative /&>ds submitt$ by ! ,committee on ,food ,/&>ds ( ! ,association ( ,(ficial ,agricultural ,*emi/s are giv5 along ) ! tabulat$ results ( ! *emical analysis4 ,! prep>ations exam9$ %[$1 = ! mo/ "p1 t !y con=m$ to ! /&>ds1 & only ^? :i* are at v>iance 9 "o or m p>ticul>s w be m5tion$ 9 ?is review4 ,,solid ,,meat ,,extracts ,= solid meat extracts ! foll[+ are ! requirem5ts3 8,meat extract is ! product obta9$ by extract+ meat ) boil+ wat] & conc5trat+ ! liquid portion by evaporation aft] removal ( fat1 & conta9s n less ?an #ge p] c5t4 total solids ( :i* n ov] #bg p] c5t4 is a% & n ov] #ab p] c5t4 is sodium *lorid 7calculat$ f ! total *lor9 pres5t71 n ov] #j4f p] c5t4 is fat & n less ?an #g p] c5t4 is nitrog54 ,! nitrog5\s comp\nds conta9 n less ?an #dj p] c5t4 ( meat bases & n less ?an #aj p] c5t4 ( kreat940 ,) ! above z ! /&>d1 sev]al ( ! solid meat extract prep>ations exam9$ 7 n up to grade on "o or m po9ts1 ?\gh 9 "s cases x is true !y 7 v slightly bel[ ! /&>d set4 ,! foll[+ products 7 f\nd want+ 9 "s respects & ! requirem5ts :i* !y fail$ to meet are giv53 8,,rex0 ,,br& ,,beef ,,extract 7,cudahy ,pack+ ,co41 ,omaha7 conta9$ #bf4ej p] c5t4 wat] in/ead ( ! /&>d #be p] c5t4 ,,extract ,,( ,,beef ,,premi] 7,libby1 ,mc,neil ,libby1 ,*icago7 conta9$ #cj4ib p] c5t4 ( a% in/ead ( ! /&>d #bg p] c5t42 #ah4cb p] c5t4 ( sodium *lorid 7/&>d1 #ab p] c5t472 #f4jb nitrog5 7/&>d1 #g p] c5t474 ,,beef ,,extract 7,swift ,co41 ,*icago7 conta9$ #ac4ea p] c5t4 sodium *lorid 7/&>d1 #ab p] c5t472 #f4fj p] c5t4 nitrog5 7/&>d1 #g p] c5t474 ,,beef ,,extract1 ,,co9 ,,special 7,g4 ,h4 ,hammond ,co41 ,hammond1 ,ind47 conta9s #ac4be p] c5t4 ( sodium *lorid 7/&>d1 #ab p] c5t472 & #f4hf p] c5t4 nitrog5 7/&>d1 #g p] c5t474 ,) ^! few exceptions1 ! solid meat extracts 7 f\nd to comply ) ! /&>ds giv54 ,,fluid ,,meat ,,extracts ,= fluid meat extract ! foll[+ /&>ds h be5 sugge/$3 8,fluid meat extract is id5tical ) meat extract except t x is conc5trat$ to a l[] degree & conta9s n m ?an #ge p] c5t4 & n less ?an #ej p] c5t4 ( total solids40 ,accord+ to ?is /&>d all except+ "o ( ! fluid meat extracts exam9$ 7 f\nd to be bel[ grade 9 "o respect1 t ( solids4 ,! foll[+ are prep>ations exam9$ & ! p]c5tage ( solids f\nd3 ,p] c5t4 ,,conc5trat$ ,,fluid ,,beef ,,extract 7,arm\r ,co41 ,*icago7 #db4be ,,meat ,,juice 7,val5t9e's ,meat ,juice ,co41 ,ri*mond1 ,va47 #db4cf ,,beef ,,juice 7,john ,wye? ,bro41 ,philadelphia7 #da4af ,,vigoral 7,arm\r ,co41 ,*icago7 #ej4jf 8,,rex0 ,,fluid ,,beef ,,extract 7,cudahy ,pack+ ,co41 ,omaha7 #dd4ja ,,fluid ,,extract ,,( ,,beef 7,cibilis ,co41 ,new ,york7 #ce4cg ,,fluid ,,beef ,,jelly 7,mosqu]a-,julia ,food ,co41 ,detroit7 #ca4jc ,special notice is direct$ to ! price ( "s ( ^! prep>ations1 :i* 9 spite ( _! l>ge wat] cont5t1 are high] pric$ ?an "s ( ! solid meat extracts4 ,,meat ,,juices ,! foll[+ is giv5 z ! /&>d = prep>ations ( meat juice3 8,meat juice 444 is ! fluid portion ( muscle fib] obta9$ by pressure or o!rwise1 & may be conc5trat$ by evaporation at a temp]ature bel[ ! coagulat+ po9t ( ! soluble proteids4 ,! solids conta9 n m ?an #ae p] c5t4 ( a%1 n m ?an #b4e p] c5t4 ( sodium *lorid 7calculat$ f ! total *lor9 pres5t71 n m ?an #d p] c5t4 nor less ?an #b p] c5t4 ( phosphoric acid 7,p#b,o#e71 & n less ?an #ab p] c5t4 ( nitrog54 ,! nitrog5\s bodies conta9 n less ?an #ce p] c5t4 ( coagulable proteids & n m ?an #dj p] c5t4 ( meat bases40 ,x is especially noticeable among ! meat juices1 s call$1 t none %[s any appreciable am\nt ( coagulable proteids4 ,val5t9e's ,meat ,juice & ,wye?'s ,beef ,juice1 besides be+ bel[ ! /&>d 9 total solids z fluid extracts1 are misbr&$ :5 call$ meat or beef juices1 z c readily be se5 by comp>+ ! results ( ! analyses & ! /&>d4 ,wye?'s ,beef ,juice is adv]tis$ z conta9+ 8all ! album9\s pr9ciples ( beef 9 an active & soluble =m0 & 89 an unalt]$ =m0--two /atem5ts t are on ! face ( !m untrue & mislead+4 ,to say t all ! album9\s pr9ciples ( meat are pres5t is to say t n only ! juice ( ! meat b all ! fib] is pres5t1 :i* evid5tly is n true4 ,!n aga91 to say t x is pres5t 9 an unalt]$ =m is f> f ! facts1 =1 z is /at$ on page #ah ( ! ,bullet93 8,x appe>s impracticable to prep>e a true meat juice = m>ket1 z ! temp]ature necess>y = ! pres]vation ( food products 9 h]metically seal$ packages coagulates ! proteids & *anges ! nature ( ! product40 ,on page #ee3 8,:5 prep>$ "u ! be/ possible conditions a comm]cial meat extract is1 ( necessity1 9 ord] t x may n spoil1 depriv$ ( ! great] "p ( ! coagulable proteids1 :i* con/itute ! *ief nutriti\s elem5ts ( ! juice40 ,on exam9+ ! tables ( analysis1 x is se5 t ,wye?'s ,beef ,juice conta9s b #bc p] c5t4 ( its total proteids 9 a coagulable =m1 :ile ! /&>d calls = #ce p] c5t41 ?us %[+ x to be no m valuable z a food product ?an any o!r s-call$ meat juice1 ! /atem5ts ( ! manufactur]s to ! contr>y not)/&+4 ,9 ! case ( ,val5t9e's ,meat ,juice we note a l>ge discrepancy betwe5 ! /&>d requirem5ts & ! results ( ! gov]nm5t analysis1 = in/ead ( ! proteid matt] conta9+ #ce p] c5t4 9 ! coagulable =m1 x conta9s b #a4f p] c5t4 ,^! figures %[1 !n1 t ,val5t9e's prep>ation conta9s practically no coagulable proteids1 & s9ce ! quantity ( ^! measures ! food value ( su* prep>ations1 ! conclusion mu/ be drawn t ,val5t9e's ,meat ,juice has practically no value z a food & %\ld c]ta9ly n be class$ z a meat juice4 ,bov99e1 ano!r widely adv]tis$ meat prep>ation1 :i*1 accord+ to /atem5ts on 8,! ,bov99e ,co4's0 lett] head1 is 8a conc5trat$ beef juice0 & 8! only p]fect food 9 ! _w0 0 analyz$ & f\nd bel[ ! /&>d set = meat juices1 s9ce x conta9s only #c4ch p] c5t4 ( coagulable proteids4 ,yet 9 spite ( ?is discrepancy1 ! manufactur]s ( ,bov99e p]si/ 9 exploit+ x z a food1 /at+ x to be 8444 a conc5trat$ easily assimilable1 nitrog5\s food10 & 9 ano!r place x is /at$ t ,bov99e 8is an ideal food40 ,z x is defici5t 9 coagulable proteids & ?us bel[ ! requirem5ts z a food1 x is misbr&$ :5 call$ a food ( any sort1 = to quote aga9 ! ,bullet91 page #ee3 8444 meat extracts 444 mu/ n be look$ on z repres5t+ 9 any notable degree ! food value ( ! beef or o!r meat f :i* !y are d]iv$02 &1 aga93 8,!y are n1 h[ev]1 conc5trat$ foods1 hav+1 on ! contr>y1 b comp>atively little nutritive value40 ,tak5 individually or z a class1 meat extracts are n to be consid]$ foods1 & %\ld1 !re=e1 n be adv]tis$ z su*1 a conclusion :i* ! gov]nm5t (ficials h come to & voic$ 9 ! conclusion ( ! ,bullet9 z foll[s3 ,,value ,,& ,,limitations 8,x seems to be ! cons5sus ( op9ion among sci5tific inve/igators :o h /udi$ ?is "q t ! food value ( ^! meat extracts is r limit$1 & al?\gh !y are a s\rce ( en]gy to ! body !y mu/ n be look$ on z repres5t+ 9 any notable degree ! food value ( ! beef or o!r meat f :i* !y are d]iv$4 ,:5 prep>$ "u ! be/ possible conditions a comm]cial meat extract is ( necessity1 9 ord] t x may n spoil1 depriv$ ( ! great] "p ( ! coagulable proteids1 :i* con/itute ! *ief nutriti\s elem5ts ( ! juice40--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,jan4 #bc1 #aijh47 ,,ph>maceutical ,,manufactur]s ,,& ,,! ,,great ,,am]ican ,,fraud ,at v>i\s times we h giv5 m or less complete acc\nts ( ! prosecutions ! ,unit$ ,/ates ,gov]nm5t has br\ght aga9/ no/rum exploit]s "u ! ,food & ,drugs ,act4 ,"o ( ! m rec5t ( ^!1 :ile ( comp>atively little int]e/ p] se1 is ( importance to ! m$ical pr(ession1 because ( c]ta9 elem5ts connect$ ) x4 ,! case is kn[n te*nically z 8,notice ( ,judgm5t ,no4 #bhd0 & deals ) ! 8,alleg$ ,misbr&+ ( ,d&]9e40 ,! gi/ ( ! case is z foll[s3 ,casks ( ,d&]9e--a widely adv]tis$ 8hair tonic0--7 %ipp$ 9 c>load lots f ,mi*igan to ,we/ ,virg9ia1 :]e ! product 0 bottl$1 label$ & put 9 condition to be retail$4 ,d&]9e conta9s a p]c5tage ( alcohol :i*1 :ile giv5 on ! labels ( ! bottles 9 :i* x is sold1 0 n /at$ on ! casks 9 :i* ! prep>ation 0 %ipp$ 9 bulk4 ,! gov]nm5t s\ght to confiscate1 "u ! ,food & ,drugs ,act1 sixty-five casks ?us %ipp$ because ! quantity or proportion ( alcohol 9 ! casks 0 n /at$4 ,! ,kn[lton ,d&]9e ,company resi/$ ! confiscation & ! c\rt upheld ! company's claim4 ,! po9t 9 ?is case :i* is--or %\ld be--( int]e/ to ! m$ical pr(ession is to be f\nd 9 ! 8/atem5t ( facts0 pres5t$ by ! ,kn[lton ,d&]9e ,company 9 its own def5se4 ,"h x is said t3 8,p>ke1 ,davis ,co41 :o are m5tion$ 9 ! said libel z %ipp]s 444 are "u contract ) ! said ,kn[lton ,d&]9e ,company 444 to comp\nd ! said =mula 4440 ,else:]e x is /at$3 8,p>ke1 ,davis ,co4 7 444 ! manufactur+ ag5ts1 "u contract1 ( ! own]1 ! ,d&]9e ,company 4440 ,?is evid5tly means t ,p>ke1 ,davis ,co41 :o are g5]ally suppos$ to manufacture only 8e?ical0 prep>ations--propriet>y or o!rwise--& z su* to desire ! respect & good wi%es ( ! m$ical pr(ession1 are 9 ! bus9ess ( furni%+ ! supplies = no/rum v5d]s4 ,:at ,d&]9e is1 x is h>dly necess>y to specify4 ,! widely di/ribut$ adv]tisem5ts ( ?is 8hair tonic0 no/rum ) ! slogan3 8,d&]9e ,gr[s ,hair & ,we ,c ,prove ,x0 are suffici5tly well-kn[n to all :o read to make a l5g?y disquisition on ! product unnecess>y4 ,x is int]e/+ 9 ?is connection to note t accord+ to newspap] dispat*es ! ,d&]9e ,company has absorb$ ! ,/]l+ ,rem$y ,company1 :i* exploits 8,casc>ets40 ,?ree ye>s ago a physician1 :o is also a ph>maci/1 wrote to ! ,m$ical ,_w reg>d+ ! manufacture ( ,casc>ets3 8444 ,i h positive evid5ce1 :i* ,i w gladly submit1 t ,p41 ,d4 ,co41 make all ( !m ,casc>ets1 & t !y h a contract ) ! ,casc>et p n to make any?+ simil> = any "o else40 ,9 ! circul> :i* comes 9 ! ,d&]9e packages two o!r 8specialties0 are adv]tis$3 8,neuralg9e0 = 8sick1 weak1 tir$ n]ves0 & 8,drake's ,palmetto ,comp\nd0 = 8weak /oma*s1 sluggi% liv]s1 disord]$ kidneys10 & v>i\s o!r d]angem5ts ( ! sy/em4 ,! "q naturally arises1 are ^!1 too1 %ipp$ 9 casks f ,p>ke1 ,davis ,co41 & m]ely bottl$ & labell$ 9 ,we/ ,virg9ia8 ,n t ! ,d&]9e case is ! fir/ "o 9 :i* ,p>ke1 ,davis ,co4 h be5 expos$ z manufactur]s ( no/rum supplies4 8,vitaopa?y0 a me?od ( 8treatm5t0 practic$ by ! notori\s ,new ,york ,in/itute ( ,physicians & ,surgeons 9 ! p]son ( 8,pr(40 ,adk9 & app>5tly consi/+ ( 8abs5t treatm5t0 & pills1 0 f9ally put out ( bus9ess by a fraud-ord] f ! po/ (fice dep>tm5t4 ,! conc]n us$ to adv]tise3 8,9 ,pr(essor ,adk9's laboratory1 8 *emi/s are daily engag$ 9 extract+ ! life-&-heal?-giv+ pr9ciple f r>e vegetables1 fruits & plants40 8,pr(40 ,adk9 _h no laboratory2 8 *emi/s1 accord+ to ! gov]nm5t report1 7 ,p>ke1 ,davis ,co41 f :om he pur*as$ ! tablets :i* =m$ "p ( 8 /ock-9-trade ( quack]y4 ,! ,nutriola ,company ( ,*icago 0 decl>$ fraudul5t by ! po/al au?orities & a full acc\nt ( ! me?ods ( ?is fake m$ical conc]n appe>$ 9 ,! ,j\rnal1 ,april #bh1 #aijf4 ,nutriola 0 adv]tis$ z3 8,! greate/ ,*emical-,m$ical ,prep>ation ev] prep>$ by ! skill ( man40 8,nutriola & ,nature are ! only inv9cible conqu]ors ( diseases ev] kn[n40 ,! promot] ( ?is s*eme 0 "o ,edw>d ,f4 ,hanson1 :o 0 que/ion$ by ! gov]nm5t inspectors reg>d+ ! manufacture ( ! ,nutriola no/rum4 ,quot+ f ! gov]nm5t report3 8,q4 ,please "n ! *emi/s :o n[ manufacture ! rem$ies ( ! ,nutriola ,company40 8,a4 ,p>ke1 ,davis ,company1 ,detroit2 ,e4 ,l4 ,pat* ,manufactur+ ,company1 ,/oneham1 ,mass42 ,seabury ,johnson1 ,new ,york40 ,n t ! c\rse pursu$ by ,p>ke1 ,davis ,co4 is by any means an exceptional "o 9 ! ph>maceutical _w4 ,x may be recall$ t ,! ,j\rnal has previ\sly ref]r$ to ! fact t ,%>p ,dohme are report$ to make or to h made ! 8,getwell ,tablets0 = ! 8pat5t m$ic9e0 conc]n :i* exploits ! no/rum2 & t ,fr$]ick ,/e>ns ,co4 make or did make ! widely adv]tis$ 8cures0 ,%ac & ,zymole ,trokeys also has be5 m5tion$4 ,t ,seabury ,johnson made prep>ations = a fake m$ic9e conc]n 0 br\ght to light by ,mr4 ,adams 9 ! 8,great ,am]ican ,fraud0 s]ies4 ,& unque/ionably !re are _m o!rs4 ,! attitude tak5 by su* h\ses seems to be t !y are will+ to furni% any?+ 9 ! ph>maceutical l9e t anyone is will+ to pay =1 :e!r x is = legitimate use ( ! physician or ph>maci/ or = fur!r+ ! bus9ess by :i* ! ignorant or gullible sick are humbugg$ & defraud$4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,july #b1 #aiaj47 ,,d[d',s ,,phosphatomet] ,d[d's ,phosphatomet]1 accord+ to its inv5tor1 is a device 8= tak+ ! phosphatic index or pulse ( ! n]v\s sy/em40 ,its orig9ator1 ,j4 ,h5ry ,d[d1 ,m4,d41 ,buffalo1 ,n4 ,y41 writes en?usia/ically ( 8 in/rum5t3 8,physicians :o use ! ,phosphatomet] are s5d+ #ej p] c5t4 less pati5ts away = consultation1 gett+ #ge p] c5t4 bett] results at home1 because ! ,phosphatomet] tells ! cause & :at to d1 & ! ,comp4 ,phosphorus ,tonic gives results 9 #hj p] c5t4 ( all conditions ( illness40 ,! 8,comp4 ,phosphorus ,tonic0 ref]r$ to 9 ! above quotation is a sidel9e ( ,dr4 ,d[d's1 put out by ! ,ri*>dson ,company1 ( ,buffalo4 ,! /ation]y ( ! ,ri*>dson ,company gives its address z #ccd ,frankl9 ,/reet1 b directs t all communications be address$ to #dj ,nor? ,pe>l ,/reet1 :i* is ! private address ( ,j4 ,h5ry ,d[d4 ,accord+ to ! ,buffalo directories1 #ccd ,frankl9 ,/reet is ! drug /ore ( ,ar?ur ,e4 ,reimann4 ,to ^? :o read ! ,d[d 8lit]ature10 ! ,phosphatomet] w appe> to be ei!r "o ( ! wond]s ( ! age or an unsci5tific absurdity4 ,to ! ?9k+ man x w be ! latt]4 ,x pret5ds to det]m9e ! am\nt ( phosphates 9 ! sy/em4 ,?is is accompli%$--alleg$--by tak+ ! second ur9e pass$ 9 ! morn+ & mix+ a portion ( x 9 ! in/rum5t ) a solution :i* is ! well-kn[n magnesia mixture4 ,! height to :i* ! cry/als settle 9 t5 m9utes det]m9es1 accord+ to ,d[d1 ! am\nt ( phosphates6 ,0 ev] a te/ devis$ t violat$ m ( ! fir/ pr9ciples ( quantitative *emical analysis8 ,if s1 we nev] he>d ( x4 ,d[d's sy/em does n require any det]m9ation ( ! am\nt ( ur9e pass$ 9 tw5ty-f\r h\rs or ev5 ( ! am\nt pass$ at ! second micturition 9 ! morn+4 ,if a pati5t ^: ur9e 0 be+ 8te/$0 by ! ,d[d me?od1 %\ld dr9k two cups ( c(fee = breakfa/ in/ead ( "o1 8 ur9e might be s dilute t ! phosphates w\ld fall bel[ ! 8normal0 m>k4 ,d[d says t 8 ,phosphatomet] 8takes ! pulse ( ! n]v\s sy/em40 ,:at ab\t ! pati5t :o eats sev]al eggs or consumes a sweetbread or o!r nucle9-conta9+ articles ( diet8 ,! increas$ am\nt ( phosphates 9 su* a diet might easily lead to an app>5t excess 9 ! ur9e4 ,e physician1 nay1 e sophomore m$ical /ud5t1 kn[s t ! am\nt & k9d ( food +e/$ gov]ns almo/ entirely ! am\nt ( phosphates excret$ 9 ! ur9e4 ,:at actually does 8,d[d's ,phosphatomet]10 :5 us$ accord+ to in/ructions1 %[8 ,x %[s ! pres5ce ( phosphates 9 ! ur9e2 x p]mits a guess--) n ! slighte/ claim to accuracy--z to ! am\nt 9 ! specim5 te/$2 x gives no possible clue to ! normal or abnormal relation ( ! phosphates 9 ! ur9e or z to :e!r ! s\rce ( ! cry/als precipitat$ is ! n]ve tissue or ! food4 ,yet "h are "s ( ! claims made = x3 8,! ,phosphatomet] %[s n]v\s metabolism ! same z ! ureomet] %[s muscul>2 ! =m] errs 9 ab\t #c p] c5t42 ! latt] 9 #dj p] c5t40 8,! ,phosphatomet] %[s ! am\nt ( n]ve food be+ us$ & pres5t 9 ! n]ve cells40 8,ov] #ej p] c5t4 ( pa9 & human suff]+ is due to ! n]ves cry+ = food2 ! ,phosphatomet] w %[ ! true cause 9 t5 m9utes40 8,! ,index n only tells ! pres5t condition1 b =etells ! future1 ?us prev5t+ s]i\s complications :i* might arise40 8,! ,phosphatomet] measures ! am\nt ( phosphorus 9 ! sy/em40 8,! ,d[d ,phosphatomet] n only takes blood-pressure1 x tells h[ to regulate x40 8,! ,phosphatomet] measures ! am\nt ( phosphorus 9 ! n]ve cells2 x is z positive 9 n]ve tr\bles z ! x-ray 9 fractures40 ,^! claims are ess5tially false4 ,z a matt] ( fact1 a simple exam9ation ( ! ur9e = phosphates _c tell u ! condition ( ! n]v\s sy/em4 ,?is mu/ be evid5t f ! fact t only a portion ( ! phosphates is excret$ 9 ! ur9e1 a v consid]able "p pass+ out ) ! feces4 ,fur!r1 ! bulk ( ! phosphorus excret$ comes f ! food & only a small portion f ! wa/e ( ! n]v\s sy/em4 ,! am\nt excret$ by ! ur9e :i* comes f torn-d[n n]ve tissue is s small t x is practically impossible to e/imate v>iations 9 x ev5 by ! mo/ c>eful analytic me?ods4 ,9 brief1 ,d[d's 8sci5tific me?od0 is no?+ m ?an unsci5tific humbug4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,dec4 #bj1 #aiac47 ,,amorph\s ,,phosphorus,,bn ,a ,practically ,in]t ,sub/ance ,introduc$ z a ,valuable ,!rapeutic ,ag5t ,,bn ,! s-call$ amorph\s phosphorus is 9 reality a cry/all9e body & is m correctly call$ r$ phosphorus to di/+ui% x f ! ord9>y or yell[ phosphorus4 ,x is ! ord9>y or yell[ phosphorus :i* is (ficial z 8,phosphorus40 ,amorph\s phosphorus is a *emical anomaly contra/+ m>k$ly ) ord9>y phosphorus 9 its physical1 *emical & ph>macologic prop]ties4 ,ord9>y phosphorus is soluble 9 c]ta9 solv5ts1 su* z oil2 amorph\s phosphorus is insoluble4 ,ord9>y phosphorus is poison\s2 amorph\s phosphorus is n poison\s4 ,ord9>y phosphorus has be5 reg>d$ z ( "s !rapeutic value2 amorph\s phosphorus1 because ( its insolubility & o!r physical prop]ties1 has nev] be5 s reg>d$4 ,ph>macologi/s1 !re=e1 h paid v little att5tion to x4 ,"s ( !m d n ev5 m5tion x1 ?\gh !re are a few acc\nts ( exp]im5tal "w4 ,no1#aef 9 exp]im5ts on ! action ( phosphorus ) yea/1 f\nd t yea/ act$ on ord9>y phosphorus1 produc+ ,,ph#c 7hydrog5 phosphid71 b on amorph\s phosphorus x _h no action4 ,8 exp]im5ts %[ t amorph\s phosphorus 0 n toxic to animals4 #aef ,no1 ,j43 ,action comp>e du phosphore blanc et du phosphore r\ge sur la matire vivante1 ,compt4 r5d4 ,soc4 de biol41 #ahii1 #aje1 i1 #chj4 ,?ornton#aeg quotes ,reese z publi%+ a report ( a case 9 :i* #cj gra9s ( amorph\s phosphorus 7 tak5 by a "y woman ) suicidal int5t1 b no toxic symptoms 7 manife/$4 ,?ornton f\nd x non-toxic to animals4 #aeg ,?ornton1 ,e4 ,q43 ,! ,advantages ( ,amorph\s ,phosphorus ov] ! ,(ficial ,=m1 ,!rap4 ,gaz41 #ahid1 xxxv1 #ai4 ,tr4 ,pan4 ,am4 ,m$4 ,congress1 #ahic1 ,wa%+ton1 #ahie1 p4 #a1dch4 ,wit?aus & ,beck] 7,m$ical ,jurisprud5ce1 ,=5sic ,m$ic9e & ,toxicology1 iv1 #fce7 say3 8,! =m ( phosphorus is practically non-poison\s1 probably by reason ( its insolubility4 ,x has be5 adm9i/]$ to dogs to ! ext5t ( #bjj gm4 7ne>ly half a p\nd7 9 twelve days )\t caus+ poison+40 ,c4 ,d4 ,f4 ,phillips 7,mat]ia ,m$ica1 ,ph>macology & ,!rapeutics1 ,inorganic ,sub/ances1 ,ed4 #c1 p4 #df7 makes ! foll[+ /atem5t3 8,amorph\s phosphorus has be51 by "s obs]v]s1 cr$it$ ) physiologic activity4 ,?us1 ,b$n> us$ x = a long p]iod 9 small doses1 & obs]v$ symptoms ( excitation1 trembl+ & clonic convulsions2 b z mu* z #a ounce has be5 giv5 to dogs )\t p]ceptible effect4 ,?ompson1 9 twelve c>efully obs]v$ cases1 f\nd its action nil1 & plausibly attributes its suppos$ p[]s to a slight admixture ( ord9>y phosphorus 7,ph>m4 ,j\r41 #ahge74 ,i believe x is practically in]t40 ,,h[ ,,introduc$ ,! =ego+ repres5ts our sci5tific k z to ! action ( amorph\s phosphorus4 ,n[1 h[ev]1 comes ,dr4 ,i4 ,l4 ,nas*] & introduces amorph\s phosphorus z a rem$y ( rem>kable value = ! art]ioscl]osis ( old age4 ,! me?od ( introduction is some:at peculi>4 ,! treatm5t seems fir/ to h be5 br\ght to notice ?r\gh a pr9t$ slip s5t to m$ical j\rnals g5]ally4 ,?is slip consi/$ ( an extract f ,nas*]'s book on old age1 :i* at ! "t _h n be5 publi%$6 ,nas*] also publi%$ an article on ?is subject 9 an obscure j\rnal1 ! ,am]ican ,practition]1 = ,decemb]1 #aiac4 ,nei!r ! matt] copi$ f 8 book nor ! article ref]r$ to conta9 a s+le sci5tific fact t w\ld w>rant ! claims made = x z a !rapeutic ag5t4 ,no record is giv5 ( animal exp]im5ts1 & ! cl9ical evid5ce pres5t$ c]ta9ly _c be reg>d$ z sci5tific4 ,z already /at$1 ?is =m ( phosphorus has n be5 previ\sly us$ & has be5 reg>d$ z )\t effect on ! human sy/em because ( its insolubility 9 any ( ! liquids ( ! body4 ,nas*] himself has n be5 able to f9d any new way to dissolve x4 ,he says3 8,i made a numb] ( exp]im5ts to f9d a solv5t4 ,! only sub/ance :i* appe>s to dissolve x is s]um1 b ,i am /ill unc]ta9 :e!r x is a solution or a v f9e susp5sion4 ,! phosphorus is precipitat$ 9 a few days1 b ! s]um rema9s t+$40 ,! fact t x sep>ates f ! s]um on /&+ is q conclusive evid5ce t x is insoluble 9 t liquid4 ,s9ce no way ( mak+ x soluble has be5 discov]$1 !re is no reason = expect+ x to h any effect on ! sy/em4 ,an insoluble & non-absorbable sub/ance c produce no g5]al sy/emic effect2 if1 :5 +e/$1 x produces any effect :atev]1 ?is effect mu/ be local & w be %[n by symptoms ( ga/ro-inte/9al di/urbance4 ,nas*]1 h[ev]1 took #ae gra9s1 & no symptoms ( ga/ro-inte/9al di/urbance foll[$4 ,h5ce1 we mu/ conclude t x is )\t effect on ! ga/ro-inte/9al muc\s membrane4 ,:ile ,nas*] records no exp]im5ts on animals :i* is mu* to be regrett$1 he did exp]im5t on himself & says3 8,t5 gra9s produc$ a frontal heada*e1 re/lessness1 excessive m5tal /imulation1 ideas aris+ ) su* vividness z to appe> z actual occurr5ces4 ,!re 0 a s5se ( weight or oppression 9 ! /oma* & priapism1 ! latt] probably psy*ic1 z ,i 0 look+ = su* a result4 ,^! symptoms pass$ away 9 a few h\rs40 ,)\t d\bt 8 explanations ( ! priapism c be appli$ to ! :ole exp]i5ce2 :atev] symptoms !re 71 !y 7 unque/ionably psy*ic4 ,! consid]ation ( ^! subjective symptoms may be dismiss$1 s9ce x is reasonable to assume t an insoluble1 unabsorbable sub/ance :i* produces no di/urbance ( ! ga/ro-inte/9al tract w h no effect on ! re/ ( ! organism4 ,amorph\s phosphorus did n produce su* symptoms z ,nas*] relates 9 exp]im5ts simil> to 8 made by u4 ,! drug 0 tak5 9 #aj-;gra9 doses by six diff]5t individuals4 ,9 no case did ! symptoms describ$ by ,nas*] foll[2 9 fact1 !re 7 no symptoms :atev]4 ,,nas*]',s ,,!ory ,nas*]1 aft] relat+ 8 subjective exp]i5ces & ^? ( 8 pati5ts1 proce$s to build a !ory to acc\nt = ! unprov$ action ( amorph\s phosphorus 9 disease1 especially 9 art]ioscl]osis4 ,x w\ld h be5 m appropriate if be=e advanc+ ! !ory1 he _h made "s exp]im5ts to prove t ! sub/ance has "s action4 ,b we give 8 !ory z f\nd 9 ! quotation f 8 book1 s5t to m$ical j\rnals1 z already ref]r$ to4 ,"h x is3 8,amorph\s ,phosphorus 9 ,s5ile ,art]ioscl]osis3 ,! au?or has us$ ! r$ amorph\s phosphorus 9 s5ile art]ioscl]osis = sev]al ye>s4 ,giv5 orig9ally z a sub/itute = ord9>y phosphorus 9 s5ile debility1 x 0 f\nd t x 0 elim9at$ z amorph\s phosphate ( lime & t ! lime elim9ation 0 !reby increas$4 ,weil's exp]im5ts %[$ t ! lime elim9ation 9 art]ioscl]osis 0 dim9i%$4 ,phosphorus has ! prop]ty ( comb9+ ) lime & increas+ ! lime assimilation4 ,9 ! small doses :i* c be giv5 :5 ! ord9>y phosphorus is employ$1 ! phosphorus w comb9e ) ! lime ( ! food & increase ! am\nt ( lime salts 9 ! body4 ,:5 giv5 z amorph\s phosphorus1 ! dose is #b gra9s or m sev]al times a day1 & ) a lime-free diet ! lime requir$ = ! comb9ation necess>y to secure ! elim9ation ( ! phosphorus excess is drawn f ! abnormal lime deposits4 ,?is appe>s to be ! rationale ( ! treatm5t & expla9s ! good results obta9$ f its use4 ,f #8,diseases ( ,old ,age1' by ,i4 ,l4 ,nas*]1 ,m4,d41 to be publi%$ %ortly40 ,?us1 accord+ to ,nas*]1 ! phosphorus1 aft] be+ oxidiz$ to phosphoric acid1 cat*es ! calcium & drags x out ( ! sy/em6 ,:at are ! facts8 ,! human body conta9s a l>ge /ore ( phosphates :i* are excret$ 9 ! ur9e 9 comb9ation ) sodium & potassium--& yet ^! d n draw ! calcium f ! blood1 bra9 & bones6 ,to be blunt1 ,nas*]'s !ory is absurd4 ,! calcium 9 its v>i\s deposits 9 ! body is already comb9$ ) phosphoric acid4 ,:y %\ld ! phosphorus introduc$ take calcium f ! phosphate radical ) :i* x is already 9 comb9ation8 ,nas*] ass]ts t ! phosphorus :i* is introduc$ z amorph\s phosphorus is excret$ z amorph\s phosphate ( lime )9 tw5ty-f\r h\rs4 ,h[ does he "k x is8 ,x is1 ( c\rse1 v appropriate t amorph\s phosphorus %\ld =m ! amorph\s phosphate ( lime1 b1 un=tunately1 phosphates made f ! ord9>y phosphorus also are precipitat$ 9 ! amorph\s condition4 ,by :at private m>k does ,dr4 ,nas*] id5tify ! amorph\s phosphate produc$ by 8 amorph\s phosphorus8 ,is x n a fact t he f\nd ! ur9e alkal9e & detect$ a precipitate ( amorph\s calcium phosphate--always pres5t 9 alkal9e ur9e--& conclud$ t ?is mu/ be 8 p>ticul> amorph\s phosphorus 9 comb9ation ) calcium8 ,dr4 ,nas*] makes no record ( exam9ations ( ! feces1 al?\gh a great "p--sometimes ! great] "p--( +e/$ phosphorus is f\nd 9 ! feces 9 exp]im5tal "w on phosphorus metabolism4 ,if he _h exam9$ ! feces he w\ld d\btless h f\nd ! total quantity ( amorph\s phosphorus un*ang$4 ,nas*] ref]s to sev]al cases 9 :i* he has us$ ?is rem$y & /ates t he _h ! mo/ gratify+ results4 ,s f> z we c le>n1 ! b5efit 0 entirely 9 ! subjective symptoms ( ! pati5t4 ,x seems evid5t1 !re=e1 t 8 claims = ! value ( ?is rem$y re/ on no bett] f\ndation ?an an unprov$ !ory )\t exp]im5tal basis4 ,,its ,,comm]cialization ,?us f> we h consid]$ only ! sci5tific aspects ( amorph\s phosphorus !rapy4 ,x is un=tunate t we _c /op "h4 ,"s ( our read]s w h se5 9 rec5t m$ical j\rnals half-page adv]tisem5ts ( amorph\s phosphorus read+3 ,! /rik+ physical & *emical prop]ties possess$ by common phosphorus1 toge!r ) ! fact t phosphorus is "o ( ! con/itu5ts ( n]ve-tissue1 are probably responsible = ! reputation :i* ?is elem5t acquir$ g5]ations ago z a rem$y = sexual impot5ce & m5tal decay4 ,among sci5tific m5 ?is reputation 0 a fleet+ "o1 =1 :5 put to ! te/1 ! product fail$4 ,l s _m products ) a simil> hi/ory1 ! une>n$ reputation x obta9$ f m$ical m5 surviv$ 9 ! m9ds ( ! laity1 &1 z is always ! case1 ! survival has be5 tak5 advantage ( by quacks4 ,among *>latans & no/rum mak]s phosphorus is /ill 9 vogue4 8,weak m5's speciali/s0 & v5d]s ( 8lo/ manhood0 & alleg$ aphrodisiac drugs 8play up0 ! phosphorus fallacy = all x is wor?4 ,x is wor? not+ t ! pres5t exploitation ( amorph\s phosphorus is foll[+ along some:at simil> l9es4 ,! ass]t$ actions ( amorph\s phosphorus are su* z may be calculat$ to appeal to ! sexual neura/h5ic4 ,!re is no d\bt t ! ,%>p ,dohme adv]tisem5ts w br+ ab\t an ext5sive use ( ?is rem$y1 especially by ! uncritical4 ,! psy*ic elem5t--:i* plays s l>ge a "p 9 ! sexual neura/h5ic--w result 9 favorable reports be+ giv5 on ! drug4 ,articles may be expect$ to appe> 9 a c]ta9 class ( m$ical j\rnals1 tell+ ( ! m>vel\s results t ,dr4 ,john ,doe has _h 9 ! use ( 8,pill ,phosphorus ,amorph\s ,s4 ,d40 ,a luxuriant crop ( te/imonials may be expect$ to foll[1 & ! t\t ensemble w g f> to su/a9 ! ,%>p ,dohme propag&a4 ,illu/ration3 ,reproduction--r$uc$--( half-page adv]tisem5t appe>+ 9 m$ical j\rnals4 ,we are prompt$ to believe t ,messrs4 ,%>p ,dohme d n fully realize ! pot5tialities = h>m t lie 9 _! pres5t exploitation ( amorph\s phosphorus4 ,x h>dly seems possible t a firm ( /&+ w\ld kn[+ly put on ! m>ket & adv]tise a wor?less drug ) an appeal to susceptible1 infirm old m54 ,! function ( introduc+ new rem$ies to ! m$ical pr(ession is a responsible "o1 & a firm t assumes x %\ld h among its (fic]s "s "o suffici5tly conv]sant ) ph>macologic sci5ce to prev5t su* unsci5tific absurdities z t exhibit$ 9 ! m>ket+ ( amorph\s phosphorus1 especially "u su* claims z ^? conta9$ 9 ! adv]tisem5ts4--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,m>* #g1 #aiad47 ,dr4 ,nas*]'s ,reply to ,! ,j\rnal's ,article--,comm5ts ,to ! ,editor3--,reg>d+ ! article on ,amorph\s ,phosphorus 9 ! ,m>* #g issue ( ,! ,j\rnal ( ! ,am]ican ,m$ical ,association1 ,i want fir/ ( all to cle> myself ( ! impli$ *>ge ( comm]cialism 9 connection ) ! m>ket+ ( ! ,pill ,phosphorus ,amorph\s by ,%>pe ,dohme4 ,i h nev] _h any?+ to d ) ! manufacture or sale ( ^? pills1 nev] _h any bus9ess deal+s ) ,%>pe ,dohme & ,i h no comm]cial int]e/ :atsoev] 9 ei!r ?is or any o!r drug or drug h\se4 ,i knew no?+ ab\t ! adv]tisem5t :i* y reproduc$ until ,i saw x 9 ! m$ical j\rnals4 ,i imm$iately prote/$ aga9/ ?is unw>rant$ use ( my "n & 0 assur$ t ! /atem5t 8,made "u ! direction ( ,doctor ,i4 ,l4 ,nas*]1 ,new ,york10 0 n made = ! purpose ( mislead+ & t ! ad4 w\ld be imm$iately )drawn4 ,i gave my approval to ! pills made by ?is firm z ,i w\ld give my approval to ! pills made by any o!r reliable h\se = ,i claim ! "r to endorse any drug or prep>ation :i* ,i believe to be ( value :e!r x is approv$ by ! ,c\ncil ( on ,ph>macy & ,*emi/ry or n4 ,9 y\r g5]al *>ge ( comm]cialism y make x appe> t ! exploitation ( amorph\s phosphorus _h ! ult]ior purpose ( appeal+ to ! sexual neura/h5ic along ! l9es ( ! 8lo/ manhood0 ads4 ,s f> z ?is relates to ,%>pe ,dohme1 ,i h no int]e/1 b y h includ$ me 9 y\r g5]al d5unciation4 ,! only ref]5ce ,i ev] made to aphrodisiac effects ( ,amorph\s ,phosphorus1 9 all my writ+s1 is conta9$ 9 ^! words 9 ! f\r-page article 9 ! ,am]ican ,practition]1 8,9 a few cases aphrodisiac effects 7 notic$40 ,i h nev] recomm5d$ amorph\s phosphorus z an aphrodisiac & 9 ! *apt]s on 8,impot5ce & ,neura/h5ia0 9 my book on 8,diseases ( ,old ,age10 ,i h n m5tion$ amorph\s phosphorus at all4 ,y say 8! treatm5t seems fir/ to h be5 br\ght to notice ?r\gh a pr9t$ slip s5t to m$ical j\rnals g5]ally40 ,?is slip conta9+ an extract f my book :i* 0 !n 9 press 0 s5t out ab\t f\r mon?s ago :ile ,i h ref]r$ to amorph\s phosphorus repeat$ly 9 m$ical articles dur+ ! pa/ ?ree ye>s4 ,9 my pap] on ,s5ile ,debility1 ,m$ical ,record1 ,jan4 #ba1 #aiaa1 ,i said amorph\s phosphorus _h no effect1 z ,i 0 !n look+ = ! usual effects ( ! ord9>y phosphorus4 ,9 a pap] on ,s5ile ,m5tality1 ,int]national ,cl9ics1 ,vol4 #d1 #ba/ s]ies1 ,i said ,i 0 us+ amorph\s phosphorus b _h n yet det]m9$ its value4 ,i recomm5d$ x 9 sev]al ( my pap]s1 articles & lectures 9 #aiab & #aiac aft] ,i _h f\nd t "u its use 9 "s cases ( s5ile art]ioscl]osis1 symptoms 7 reliev$4 ,i s5t ^! slips to ! m$ical j\rnals z a g5]al reply to _m inquiries ,i receiv$ ab\t amorph\s phosphorus & ,i /at$ ?is 9 ! lett]s ,i s5t ) ! slips to "s editors4 ,fur!r inquiries = m in=mation l$ me to write ! pap] :i* appe>$ 9 ! ,decemb] issue ( t 8obscure j\rnal0 ! ,am]ican ,practition]4 ,i felt t a m$ical j\rnal :i* c>ri$ articles by ,sir ,james ,b>r1 ex-presid5t ( ! ,briti% ,m$ical ,association1 ,sir ,r4 ,w4 ,philip1 ,r4 ,murray ,leslie1 ,halliday ,su!rl&1 & su* ,am]ican au?orities z ,adami1 ,h>e1 ,brooks1 ,hirs*b]g1 ,knopf1 ,/>key1 ,ely1 ,bissell1 ,wilcox1 ,col4 ,maus1 ,u4 ,s4 ,a41 etc41 0 a repres5tative high class j\rnal & ,i 0 pleas$ to h my pap] 9 x4 ,to take up ! sci5tific criticism ( amorph\s phosphorus1 p]mit me to say at ! outset t ,i am a g5]al practition]1 specially int]e/$ 9 g]iatrics1 & m conc]n$ ab\t obta9+ favorable cl9ical results 9 my cases ?an 9 solv+ laboratory problems4 ,nev]!less ,i h tri$ = ye>s to obta9 ! coop]ation ( exp]t laboratory work]s to help me det]m9e ! prop]ties1 *emical1 physical & physiological1 ( amorph\s phosphorus4 ,9 #aiji or #aiaj ! ,rockefell] ,in/itute1 9 reply to my reque/ = p]mission to exp]im5t !re ) amorph\s phosphorus1 said x did n accept volunte] work]s4 ,f\r heads ( college laboratories c\ld n sp>e ! "t4 ,i ask$ ! ,c\ncil on ,ph>macy & ,*emi/ry la/ ,novemb] to take up its inve/igation & 0 in=m$ t x c\ld n d s at pres5t4 ,i h be5 p]=ce compell$ to dep5d ma9ly on empirical me?ods ) su* little exp]im5tation z ! facilities ( ! physician's (fice p]mitt$ & su* little lit]ature z ,i c\ld f9d4 ,y reject empirical me?ods z be+ unsci5tific not)/&+ ! fact t mo/ ( our !rapeutic k is bas$ on empiricism4 7,i use ! t]ms empirical & empiricism "h 9 ! s5se ( k obta9$ f exp]i5ce & obs]vation1 n 9 ! bad s5se 9 :i* !y might be con/ru$47 ,x w\ld !re=e be folly on my "p to argue ) y t ,i h obta9$ b5eficial results f amorph\s phosphorus 9 _m cases ( s5ile art]ioscl]osis4 ,i did n obta9 su* results f a s+le dose1 b gave x 9 "s cases = _m weeks or mon?s4 ,x is unfair to judge ( ! value ( a drug f a s+le dose or sev]al doses unless x is a drug :i* is expect$ to %[ imm$iate effects4 ,x w\ld be great] folly on my "p to pit my k ( ph>macy & *emi/ry aga9/ ! k ( y\r /aff ( exp]ts4 ,i c b repeat :at ,i h said on _m occasions t "u ! p]si/5t use ( amorph\s phosphorus 9 cases ( s5ile art]ioscl]osis symptoms 7 frequ5tly reliev$4 ,i nev] claim$ t amorph\s phosphorus w cure art]ioscl]osis4 ,9 ! *apt] on ,art]ioscl]osis 9 my book ,i say3 8,s5ile art]ioscl]osis be+ a natural1 normal condition1 is incurable 9 ! s5se t x c be nei!r prev5t$ nor remov$4 ,! be/ t we c hope = is to ret>d its progress & relieve disagreeable symptoms1 etc40 ,y say 9 ref]5ce to ! elim9ation ( ! amorph\s phosphorus z amorph\s phosphate ( calcium1 8,is x n a fact t he 7,i7 f\nd ! ur9e alkal9e & detect$ a precipitate ( amorph\s calcium phosphate--always pres5t 9 alkal9e ur9e--& conclud$ t ?is mu/ be 8 p>ticul> amorph\s phosphorus 9 comb9ation ) calcium80 ,no4 ,! specim5s ( ur9e 7 exam9$ 9 reliable laboratories & ,i h reports %[+ acid & neutral ur9e z well z alkal9e ur9e hav+ ! amorph\s phosphate precipitate4 ,nor is ! amorph\s phosphate 8always pres5t 9 alkal9e ur9e40 ,z = ! !ory ,i advanc$1 x is simply a !ory bas$ on reason+ )\t facts to prove x4 ,if ,i _h facts to prove x1 x w\ld no long] be a !ory or op5 = discussion4 ,be+ a !ory1 x is ! prov9ce ( ! wise man to ridicule x & call x absurd4 ,i w confess t y\r criticism ( x is n cle> to me & ,i /ill d n see its absurdity4 ,i don't see :at relation y\r argum5t1 t ! phosphates ( sodium & potassium d n draw ! calcium f ! blood1 bra9s & bones1 has to ! !ory ,i advanc$4 ,x is true t ,i h no private m>k by :i* ,i c id5tify ! amorph\s phosphate produc$ by amorph\s phosphorus1 b su* argum5t is pu]ile4 ,:5 m$ical sci5ce has s f> progress$ t ! physician w be able to put 8 tag on ! molecule ( drug sub/ance & foll[ x ?r\gh ! v>i\s metabolic processes to its f9al elim9ation we w n ne$ any ,c\ncil on ,ph>macy & ,*emi/ry to decry :at x _c und]/&4 ,let me say "h t sci5tific criticism does n /oop to ridicule = ridicule is usually bas$ on animus or bias4 ,! conclusive pro( ( ! value ( a drug is n its action on ! heal?y dog1 frog or gu9ea-pig b its action on ! individual pati5t1 & no am\nt ( animal exp]im5tation c dispose ( ! p]sonal factor :i* is s m>k$ 9 s5ile cases4 ,?is is no criticism ( animal exp]im5tation z a :ole b ( ! insi/5ce on animal exp]im5tation to det]m9e ! value ( a drug 9 a class ( cases = :i* ! heal?y animal c furni% no comp>ison4 ,y say amorph\s phosphorus is practically in]t & quote ,no1 ,wit?aus & ,beck]1 ,?ornton & ,phillips4 ,! quotations ( ! fir/ ?ree are little m ?an /atem5ts t amorph\s phosphorus is non-toxic4 ,phillips makes two ref]5ces1 "o ( :i* is to ,badn] :o obta9$ decid$ effects f its prolong$ use4 ,?ornton1 :om y quote 9 y\r cont5tion t amorph\s phosphorus is in]t1 says t on prolong$ use 9 doses ( #c_/aj gra9s e two h\rs x produc$ heada*e1 v]tigo1 m5tal excitem5t1 priapism1 etc4 7,see footnote "u ,phosphorus1 ,u4 ,s4 ,disp5satory74 ,%oemak]'s ,mat]ia ,m$ica & ,!rapeutics says x is toxic & is call$ ! s]vant-girl's poison4 ,phillips sugge/$ t ,badn] probably us$ an impure drug4 ,i sugge/$ t ,?ornton probably us$ an impure drug4 ,on ! o!r h&1 ,badn] & ,?ornton obta9$ positive results f prolong$ use1 n f ! s+le dose4 ,y say x has n be5 us$ on acc\nt ( its insolubility 9 any ( ! liquids ( ! body4 ,roscoe & ,s*orlemm]1 quot+ ,neuman1 said if inject$ into ! blood ! usual symptoms ( phosphorus poison+ appe>4 ,9 a lett] f ,dr4 ,hat*] he says ,nass inject$ #j4b gm4 ( ! pure/ amorph\s phosphorus into a rabbit's ve9 & ! animal pres5t$ ! usual symptoms ( phosphorus poison+4 ,!re are also ref]5ces to amorph\s phosphorus action 9 ,kob]t's ,lehrbu* d] ,intoxication51 9 ,bly!'s ,poisons1 etc4 ,y say ( y\r f\r quotations1 8! =ego+ repres5ts our sci5tific k z to ! action ( amorph\s phosphorus40 ,did y n "k ( ^! o!r au?orities1 or are _! /atem5ts unsci5tific1 or 7 !y omitt$ because !y disprove y\r cont5tion t amorph\s phosphorus is practically in]t8 ,y\r d5unciation ( ord9>y phosphorus has no be>+ on ! subject z ,i d n recomm5d ! amorph\s phosphorus z a sub/itute = ! o!r4 ,i h work$ = eight ye>s to ar\se m$ical & public int]e/ 9 ! ag$ & _! ailm5ts & ,i _c af=d *>ges ( comm]cialism1 foi/+ wor?less drugs z aphrodisiacs or o!r une?ical conduct to /& aga9/ me4 ,z = ! *>ge ( unsci5tific "w1 ,i c only po9t to my "w on ,diseases ( ,old ,age1 & my m$ical pap]s1 & express ! hope t o!rs bett] equipp$ = laboratory rese>* w take up ! laboratory inve/igation ( amorph\s phosphorus4 ,i h fai? 9 its !rapeutic value & believe compet5t cl9ical obs]v]s w h favorable results f x 9 suitable cases4 ,i4 ,l4 ,nas*]1 ,m4,d41 ,new ,york4 ,comm5t4--,accompany+ ! prec$+ lett] 0 a note f ,dr4 ,nas*] 9 :i* he says3 8,i want ?is publi%$ 9 full )\t elision or *ange4 ,if y d n int5d to publi% x z writt51 ,i want x return$ & enclose po/age40 ,! lett] !re=e is giv5 9 full 9 spite ( ! fact t mu* ( x is irrelevant to ! "q discuss$4 ,dr4 ,nas*]'s prote/ to ,%>pe & ,dohme aga9/ ! 8unw>rant$ use0 ( 8 "n 9 connection ) 8,pill ,phosphorus ,amorph\s1 ,s ,d0 seems to h result$ 9 v>i\s modifications ( ! phrases connect+ 8 "n ) ! exploitation ( ?is pill4 ,:at 0 app>5tly ! orig9al adv]tisem5t1 conta9$ ! phrase3 8,made "u ! direction ( ,dr4 ,i4 ,l4 ,nas*]1 ,new ,york40 ,lat] adv]tisem5ts1 :ile id5tical 9 all o!r respects ) ! fir/1 _h ?is phrase modifi$ to read3 8,made at ! sugge/ion ( ,dr4 ,i4 ,l4 ,nas*]1 ,new ,york40 ,/ill o!r adv]tisem5ts1 also id5tical ) ! fir/ 9 o!r respects1 are modifi$ to read3 8,made ) ! approval ( ,dr4 ,i4 ,l4 ,nas*]1 ,new ,york40 ,t ,dr4 ,nas*] 0 directly or indirectly connect$ ) ! comm]cializ+ ( ?is product1 ,! ,j\rnal has nev] sugge/$1 inf]5tially or o!rwise4 ,t ! exploitation ( amorph\s phosphorus by ,%>pe & ,dohme is "o t appeals to ! sexual neura/h5ic1 no "o :o has read ! adv]tisem5ts c d5y4 ,z a matt] ( fact1 x w\ld be difficult to sell phosphorus 9 any =m z a m$icam5t1 )\t appeal+ to ! sexual neura/h5ic4 ,! ^w 8phosphorus0 has become1 9 ! m9ds ( bo? laym5 & physicians1 m or less synonym\s ) ! treatm5t ( s-call$ sexual weakness & x is a practical impossibility to divorce ! ^w f ! idea sugge/$4 ,h[ true ?is is1 ,dr4 ,nas*] himself unwitt+ly admits :5 he tells t ! result ( 8 fir/ exp]im5t on himself ) amorph\s phosphorus 0 a priapism t he ackn[l$ges 0 8probably psy*ic1 z ,i 0 look+ = su* a result40 ,b ! ,%>pe & ,dohme adv]tisem5ts pla9ly /ate t ! amorph\s phosphorus pill !y are m>ket+ is a 8new & successful me?od ( treatm5t = 444 functional & s5ile impot5ce44440 ,dr4 ,nas*]'s explanation ( h[ he came to s5d out ! slip reg>d+ amorph\s phosphorus to m$ical j\rnals leaves him ! victim ( an un=tunate co9cid5ce4 ,x is at lea/ unusual = au?ors to s5d out advance extracts f books t are ab\t to be publi%$1 especially :5 su* extracts deal :olly ) a drug t is co9cid5tly be+ introduc$ z a new propriet>y product by "s ent]pris+ ph>maceutical h\se4 ,dr4 ,nas*] takes exception to our /atem5t t ! treatm5t seems fir/ to h be5 br\ght to notice ?r\gh ! pr9t$ slip s5t to m$ical j\rnals1 & /ates t he has 8ref]r$ to amorph\s phosphorus repeat$ly 9 m$ical articles appe>+ dur+ ! la/ ?ree ye>s40 ,8 articles = #aiab & #aiac h be5 exam9$ = ! purpose ( le>n+ :5 ! treatm5t z n[ pres5t$ to ! pr(ession 0 fir/ ann\nc$4 ,9 8 article 8,errors 9 ! ,treatm5t ( ,s5ile ,cases10 ,new ,york ,m$ical ,j\rnal1 ,oct4 #ab1 #aiab1 he speaks ( ! iodids 9 s5ile art]ioscl]osis1 b says no?+ ab\t amorph\s phosphorus4 ,x may be assum$1 !re=e1 t ! treatm5t _h n be5 br\ght to g5]al notice at t "t4 ,! new treatm5t is v briefly describ$ 9 ! ,new ,york ,m$ical ,j\rnal1 ,july #ac1 #aiac1 9 an article ^: title1 8,longevity & ,rejuv5esc5ce0 gave no indication t x dealt ) amorph\s phosphorus4 ,"u ! circum/ances1 x is n /range t its !rapeutic value 0 n le>n$ ( until ,dr4 ,nas*]'s pr9t$ slips 7 s5t out4 ,dr4 ,nas*] admits t 8 !ory is bas$ on empirical me?ods4 ,mo/ ( ! s]i\s errors 9 !rapeutics h _h _! orig9 9 ?is v me?od4 ,x 0 on j su* me?ods t physicians report$ wond]ful results 9 ! use ( alleg$ 8li?ia wat]s0 t actually conta9$ less li?ium ?an ord9>y riv] wat]6 ,s unsci5tific is ! empirical me?od t x is h>dly wor? tak+ ! space to demon/rate its imp]fections4 ,nei!r is x wor? :ile to discuss ! "q ( a con/ant occurr5ce ( a s$im5t ( amorph\s calcium phosphate 9 alkal9e ur9e4 ,if !re are exceptions to ?is rule1 !y mu/ be r>e inde$4 ,9 ,! ,j\rnal's article au?ors 7 quot$ to %[ t amorph\s phosphorus is reg>d$ z in]t4 ,x 0 n sugge/$ t ! au?orities ref]r$ to 7 all t c\ld be f\nd4 ,dr4 ,nas*] ref]s to ,?ornton1 ,%oemak]1 ,neuman1 ,bly! & ,kob]t1 & asks :e!r ! v>i\s /atem5ts on ! subject1 made by ^! m51 are unsci5tific or 7 8omitt$ because !y disprov$0 ! cont5tion t amorph\s phosphorus is practically in]t4 ,?ornton's article 0 omitt$ because x is unsci5tific 9 t he does n report exp]im5ts made by himself1 b ref]s to an unpubli%$ pap] by "o ,kelly4 ,:o ,kelly is1 or 01 he does n tell u4 ,kelly's report1 !re=e1 %\ld be & 0 disreg>d$1 s9ce x is ! "w ( an unkn[n au?or & !re is no?+ 9 ! article to indicate t ,?ornton 0 9 any position to v\* = ,kelly's "w4 ,incid5tally1 x may be said t ,kelly's report m]ely record$ subjective symptoms2 ,dr4 ,nas*] himself indicates 8 di/ru/ ( ,kelly's alleg$ results by sugge/+ t an impure prep>ation 0 us$6 ,%oemak]'s report 0 n giv51 = a simil> reason4 ,%oemak] says3 8,amorph\s phosphorus is almo/ completely de/itute ( ta/e or odor1 has no imm$iate cau/ic effect1 & is claim$ to be less toxic ?an :ite phosphorus2 b 9 ! =m ( mat*es ,italics ours4--,ed4 has caus$ _m dea?s & is kn[n z ! #8s]vant girls' poison4'0 ,x is well kn[n t comm]cial amorph\s phosphorus is usually impure1 & x is m ?an probable t if toxic effects 7 produc$ by ! +e/ion ( mat*-heads1 ^! mat*es 7 made ei!r ( :ite phosphorus or ( v impure r$ phosphorus4 ,9 any case1 ,%oemak]'s /atem5t has no be>+ :atev] on ! ph>macologic action ( pure amorph\s phosphorus4 ,! /atem5t ( ,neuman quot$ f ,roscoe & ,s*orlemm]1 z well z t ( ,nass1 ref]r$ to by ,hat*]1 _h no be>+ on ! "q at issue1 z ^! m5 inject$ ! mat]ial into ! blood-/ream4 ,if1 :5 ! amorph\s phosphorus is inject$ into ! blood1 x produces ! ord9>y symptoms ( phosphorus poison+1 "o w\ld naturally expect ! same symptoms :5 ! sub/ance is giv5 by m\?--if amorph\s phosphorus 7 soluble or absorbable4 ,! fact t su* symptoms are n produc$ :5 amorph\s phosphorus is tak5 into ! alim5t>y canal1 su/a9s ! views held by *emi/s1 ph>macologi/s & physicians1 t ! drug is practically insoluble & unabsorbable--9 o!r words1 in]t4 ,dr4 ,nas*] decl>es t he 8nev] claim$ t amorph\s phosphorus w cure art]ioscl]osis40 ,yet he insi/s t amorph\s phosphorus removes lime f ! 8abnormal lime deposits0 t occur 9 art]ioscl]osis4 ,:at is ?is b claim+ curative action8 ,summ$ up1 ,dr4 ,nas*]'s own admissions amply confirm ! ma9 cont5tions ( ,! ,j\rnal's article4 ,he admits t he has no exp]im5tal basis = ! use ( ?is rem$y2 he admits t 8 !ory 8is simply a !ory )\t facts to prove x40 ,! only conclusions t c be rea*$ f 8 reply co9cide closely ) ! v /atem5t made by ,! ,j\rnal1 & :i* we "h reit]ate3 8,x seems evid5t1 !re=e1 t 8 claims = ! value ( ?is rem$y re/ on no bett] f\ndation ?an an unprov$ !ory )\t exp]im5tal basis40--7,f ,! ,j\rnal ,a4 ,m4 ,a41 ,m>* #bh1 #aiad47 ,,index 7,includ+ ,ref]5ces to ,articles ,n ,conta9$ 9 ,?is ,book7 ,! foll[+ is an index 7#a7 to topics discuss$ 9 ?is volume1 & 7#b7 to products discuss$ 9 reports & o!r articles n includ$ "h3 #a4 ,! ref]5ces to topics discuss$ or m5tion$ 9 ?is volume are pr9t$ 9 ,,capitals4 #b4 ,! ref]5ces to articles publi%$ else:]e are pr9t$ 9 small lett]s4 ,^! ref]5ces include pap]s publi%$ 9 ,! ,j\rnal ( ! ,am]ican ,m$ical ,association1 pap]s publi%$ 9 ! 8,annual ,reports ( ! ,c\ncil on ,ph>macy & ,*emi/ry0 & a few publi%$ 9 ! 8,annual ,reports ( ! ,*emical ,laboratory ( ! ,am]ican ,m$ical ,association40 ,a numb] ( ^! pap]s h appe>$ bo? 9 ,! ,j\rnal & 9 ! ,c\ncil ,reports4 ,9 su* cases1 = ! b5efit ( ^? :o may n h access to files ( bo? ,! ,j\rnal & ! ,c\ncil ,reports1 ref]5ces are giv5 to bo? s\rces4 ,"s ( ?is matt] is also issu$ 9 repr9t =m4 ,,page ,,abbott ,,alkaloidal ,,company1 #cg1 #ajc1 #cdd ,,abican1 #dg ,,acetanilid1 ,,h>mful ,,effects ,,(1 #cje ,,acetanilid ,,mixtures1 #i ,,acetph5etid9 ,,& ,,ph5acet9--,,_! ,,relative ,,purity1 #dad ,,acetph5etid91 ,,h>mful ,,effects ,,(1 #cje ,,ac\/icon1 #dcf ,,adeps9e ,,oil1 #afa ,,adk91 8,,pr(essor01 #dge ,,adr5al91 ,,"n1 ,,v]sus ,,! ,,"n ,,ep9ephr91 #ded ,,adv]tis+1 ,,clean1 #dah ,,ag>-,,lac ,,& ,,ag>-,,lac1 ,,inc41 #aj ,agmel 7,maguey ,products ,co471 ,! ,j\rnal1 ,oct4 #ab1 #aiab1 p4 #acib4 ,agur9 ,tablets 7,bay] ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #afb4 ,,akoll ,,biscuit1 #ddi ,,albol5e1 ,,liquid1 #afa ,alborum 7,:iteh\se ,*emical ,co41 ,inc471 ,! ,j\rnal1 ,dec4 #ab1 #aiad1 p4 #badh2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiad1 p4 #abi4 ,aletr91 ,! ,j\rnal1 ,nov4 #ac1 #aiji1 p4 #afee2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiji1 p4 #ace4 ,aletris ,comp\nd1 ,elixir 7,p>ke1 ,davis & ,co41 ,ray ,*emical ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #df4 ,,aletris ,,cordial1 #df ,,aletris ,,f>9osa1 #bjh ,alfatone 7,norwi* ,ph>macal ,company71 ,! ,j\rnal1 ,aug4 #g1 #aiae1 p4 #edh2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #fb4 ,,ali5i/ ,,& ,,neurologi/1 ,,adv]tis+ ,,91 #ca ,alkal9e ,dige/9e 7,p>ke1 ,davis & ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #dd4 ,alkalol 7,alkalol ,company71 ,! ,j\rnal1 ,nov4 #f1 #aiae1 p4 #affe4 ,,alleotone1 #bfd ,,almond ,,prep>ations1 ,,v>i\s ,,diabetic1 #dej ,,am]ican ,,j\rnal ,,( ,,cl9ical ,,m$ic9e1 ,,adv]tis+ ,,91 #cjc1 #cjd1 #cdb ,,am]ican ,,j\rnal ,,( ,,ob/etrics1 ,,adv]tis+ ,,91 #cdb ,,am]ican ,,j\rnal ,,( ,,surg]y1 ,,adv]tis+ ,,91 #ca1 #di1 #cdb1 #dbd1 #dbi ,,am]ican ,,malt$ ,,food ,,company1 #cai ,,am]ican ,,m$ic9e1 ,,adv]tis+ ,,91 #ca1 #di1 #aca1 #cjd1 #cdb1 #dbi ,,von ,,am]ong51 ,e4 ,m41 #bii ,,amilee1 #afa ,amol9 ,deodorant ,p[d] 7,amol9 ,*emical ,co471 ,! ,j\rnal1 ,feb4 #bb1 #aijh1 p4 #fbf2 ,reports ,*em4 ,lab41 #aiji1 p4 #fc4 ,,ammonol1 #i ,,ammonol ,,*emical ,,company1 #cch ,,amorph\s ,,phosphorus1 #dgh ,,anadol1 #bdf ,,analgesic ,,balm1 ,,b5gu',s1 #bfg ,,analgesic ,,cream1 ,,/e>ns'1 #bfg ,,analg9e-,,labord9e1 #aag ,analutos & ,analutos ,tablets 7,royal ,ph>maceutical ,works1 ,meppel1 ,holl&71 ,! ,j\rnal1 ,feb4 #bj1 #aiae1 p4 #fhd2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #ace4 ,,anas>c91 #aa1 #ab ,,anas>c9 ,,*emical ,,company1 #aa1 #ah ,,&]ton1 ,,dr4 ,t4 ,b41 #ah ,,an$em91 #aa1 #ab1 #af ,,an$em9 ,,*emical ,,company1 #ab1 #af1 #ah ,,angi] ,,*emical ,,company1 #agj ,,angi]',s ,,petroleum ,,emulsion1 #afi ,,angi]',s ,,?roat ,,tablets1 #agc ,,anglo-,,am]ican ,,ph>maceutical ,,company1 ,,ltd41 #eh ,,animal ,,!rapy ,,company1 #cag ,ani/am9a 7,m4 ,olivetti71 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #afb4 ,,annals ,,( ,,surg]y1 ,,adv]tis+ ,,91 #ce1 #dba ,,anodyne ,,balm1 ,p-,m ,,company1 #bfg ,,antidiabeticum-,,bau]1 #bfg ,,anti-,,jag1 #dcd ,,antikamnia1 #i1 #bfh1 #cjg ,antikamnia & ,qu99 7,antikamnia ,*emical ,co471 ,! ,j\rnal1 ,july #a1 #aije1 p4 #ee4 ,,antikamnia ,,*emical ,,company1 #bgg1 #bgi1 #cjg ,antim]i/em-,s*midt 7,laboratorium ,w4 ,s*midt71 ,! ,j\rnal1 ,m>* #h1 #aiac1 p4 #gff4 ,,anti-,,neuralgic ,,o9tm5t1 #bfg ,antiphlogi/9e 7,d5v] ,*emical ,manufactur+ ,company71 ,! ,j\rnal1 ,june #a1 #aijg1 p4 #ahge4 ,,antipyr91 ,,h>mful ,,effects ,,(1 #cje ,,antiseptic ,,p[d]1 ,,maign51 #ai ,,antiseptic ,,p[d]1 ,,tyree',s1 #ba1 #djd1 #dcf ,antiseptic ,tablets1 ,clov] 7,%>p ,dohme71 ,! ,j\rnal1 ,aug4 #bf1 #aiaa1 p4 #gee4 ,,antiseptic ,w-,a1 ,,inte/9al1 #ajc ,,anti!rmol9e1 #djc ,,anusol ,,hemorrhoidal ,,suppositories1 #bbg1 #bhj1 #bha ,,ap]gols1 #bf ,arbor ,vitae1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #ch4 ,,ar*ives ,,( ,,p$iatrics1 ,,adv]tis+ ,,91 #ca ,,arm\r ,,co41 #acc1 #dgb ,,army ,,& ,,navy ,,magaz9e1 #dcd ,,army ,,& ,,navy ,,m$ical ,,record1 #bib1 #cjj1 #dcb ,,arnold',s ,,zymotoid ,,& ,,arnold',s ,,zymotoid ,,company1 #dab ,,aromatic ,,dige/ive ,,tablets1 #bbi ,,aseptikons1 #bf ,,aspiro-,,li?9e1 #bha ,,aspiroph51 #he ,,atlanta ,,j\rnal-,,record ,,( ,,m$ic9e1 ,,adv]tis+ ,,91 #ca1 #ce1 #bif ,,atole9e1 #afa ,,atol91 #afa ,,aub]gi]',s ,,syrup ,,( ,,lactuc>ium1 #cii ,autolys9 7,autolys9 ,laboratory71 ,! ,j\rnal1 ,july #bd1 #aiae1 p4 #ccf2 ,nov4 #f1 #aiae1 pp4 #afdg1 #affb4 ,av59 ,comp\nd ,tablets 7,p>ke1 ,davis ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #dd4 ,baby ,ta5iafuge ,grape 7,grape ,capsule ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #agd4 ,bacillicide 7,prophytol ,products ,co471 ,! ,j\rnal1 ,nov4 #ad1 #aiad1 p4 #aggh2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiad1 p4 #abe4 ,,bak+ ,,p[d]1 ,,casoid1 #ddi ,,bak+ ,,p[d]1 ,,jireh ,,diabetic1 #dej ,bakurol 7,%>p ,dohme71 ,! ,j\rnal1 ,july #aj1 #aiae1 p4 #age4 ,,ball>d1 ,j4 ,f41 #aab1 #aih ,,ball>d-,,sn[ ,,l9im5t ,,company1 #dc ,,ball>d',s ,,sn[ ,,l9im5t1 #bje ,baneb]ry1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #ch4 ,baptis91 ,! ,j\rnal1 ,nov4 #ac1 #aiji1 p4 #afee2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiji1 p4 #ace4 ,,bann]man1 ,,wm41 ,,co41 ,,& ,,bann]man',s ,,intrav5\s ,,solution1 #aje ,,baptisia ,,t9ctoria1 #bji ,,b>k]',s ,,glut5 ,,foods1 #ddi1 #dej ,,battle ,,co41 #ca1 #ha1 #ajh1 #ccj ,,bau]1 ,,*>les1 #bii ,,bau]1 ,,ludwig1 #bfg ,,bau] ,,*emical ,,company1 #cff ,,baume ,,analg,,sique ,,b5gu1 #bfg ,bee1 ,honey1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #ch4 ,,beef ,,extracts1 ,,juices ,,& ,,prep>ations1 #abc1 #acc1 #dga1 #dgb ,,bell ,,co41 #aea1 #bhb1 #cef ,,bell-,,ans 7,,pa-,,pay-,,ans1 ,,bell71 #aea1 #bhb ,b5etol 7,nor!rn ,*emical ,assn471 ,! ,j\rnal1 ,april #ae1 #aiaa1 p4 #aabh2 ,reports ,*em4 ,lab41 #aiaa1 p4 #hb4 ,,betul-,,ol1 #bg ,,bey]1 ,,*>les ,,& ,,frank1 #bii ,,biosol1 #bhd ,,bis*(',s ,,diabetic ,,glut5 ,,bread1 #dej ,,bis*(',s ,,glut5 ,,fl\r1 #ddi ,,bis*(f ,,co41 #bic1 #cdd ,,biscuit1 ,,v>i\s ,,diabetic1 #ddi1 #dej ,bismu? ,iodo-,resorc9 ,sulphonate1 ,! ,j\rnal1 ,feb4 #aa1 #aiaa1 p4 #dda2 ,reports ,*em4 ,lab41 #aiaa1 p4 #ad4 ,bismu?1 ,opium & ,ph5ol ,tablets 7,hance ,bros4 ,:ite1 ,wm4 ,s4 ,m]rell ,*emical ,co41 ,p>ke1 ,davis ,co41 ,%>p ,dohme1 ,f4 ,/e>ns ,co41 ,truax1 ,gre5e ,co41 ,h4 ,k4 ,wampole ,co41 ,wm4 ,r4 ,w>n] ,co471 ,! ,j\rnal1 ,july #be1 #aijh1 p4 #ccj2 ,dec4 #ag1 #aiaj1 p4 #bafi2 ,may #f1 #aiaa1 p4 #acdd2 ,reports ,*em4 ,lab41 #aiji1 p4 #bh2 #aiaj1 p4 #he2 #aiaa1 p4 #bb4 ,bitt] ,b>k1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #ci4 ,bladd] ,wrack1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #ci4 ,,bl&9e1 #afa ,bl&9e ,laxative1 ,mul=d 7,h4 ,k4 ,mul=d ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiad1 p4 #acf4 ,blaud ,capsules & ,blaud ,ars5ic & ,/ry*n9e ,capsules1 ,fros/'s 7,c4 ,e4 ,fros/ ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #afd4 ,,bliss1 ,,alonzo ,o41 ,,company1 #dfc ,blood ,tonic1 ,alt]ative 7,p>ke1 ,davis ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #dg4 ,blue ,coho%1 ,! ,j\rnal1 ,sept4 #aa1 #aiae1 p4 #igb4 ,,boatman1 ,h4 ,f41 #dcf ,boneset1 ,tall1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #de4 ,,boone1 ,,uriel ,s41 #cjg ,borolyptol 7,palisade ,mfg4 ,co471 ,! ,j\rnal1 ,nov4 #ae1 #aiac1 p4 #ahab4 ,,b\ma1 ,,dr41 ,,sug>-,,free ,,fat-,,milk1 #ddi ,,bov99e1 #abc1 #abe1 #abf ,,bov99e ,,company1 #abc ,,bradbury',s ,,eczema ,,lotion1 #bde ,,brant1 ,j4 ,w41 ,,company1 ,,ltd1 #daa ,,breads1 ,,v>i\s ,,diabetic1 #dej ,,breakfa/ ,,food1 ,,gum ,,glut51 #dej ,,breit5ba*1 ,m4 ,j41 ,,company1 #aei ,,bri/ol-,,my]s ,,company1 #hg1 #agi ,brobor 7,gaynor-,bag/ad ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #afd4 ,bromides ) ,cyprip$ium ,comp\nd 7,truax1 ,gre5e ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #dc4 ,,bromides1 ,,peacock',s1 #bh ,,bromidia1 #ca ,,brom9-,,iod9 ,,*emical ,,company ,,& ,,brom9-,,iod9 ,,comp\nd1 #bhe ,bromo-,mangan 7,re9s*ild ,*emical ,company71 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #afe4 ,broom ,corn1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #ci4 ,,br[n',s ,,iron ,,bitt]s1 #bje ,,br[n',s ,,iron ,,bitt]s ,,company1 #dc ,brus*ett9i ,curative ,vacc9e 7,a4 ,brus*ett9i71 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #agf4 ,,brusson ,,*ocolate ,,) ,,add$ ,,glut51 #dej ,,bu*u ,,& ,,hyoscyamus ,,comp41 ,,tyree',s ,,elixir1 #djg ,bu*u & ,hyoscyamus ,comp\nd1 ,tyree's ,elixir ( 7,j4 ,s4 ,tyree71 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #afg4 ,bu*u & ,p>eira ,comp\nd ,elixir 7,p>ke1 ,davis ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #df4 ,bu*u1 ,junip] & ,acetate ,potassium1 ,elixir ( 7,pitman-,moore ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #aff4 ,budwell's ,emulsion ( ,cod-,liv] ,oil1 ,nos4 #a & #b 7,budwell ,ph>macal ,company71 ,! ,j\rnal1 ,feb4 #bj1 #aiae1 p4 #fhd2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #ace4 ,,buffalo ,,li?ia ,,wat]1 #dfg ,,buffalo ,,m$ical ,,j\rnal1 ,,adv]tis+ ,,91 #ca1 #ce1 #cjj ,,burnham',s ,,soluble ,,iod9e1 #aaj1 #bcc ,,burnham',s ,,soluble ,,iod9e ,,company1 #aaj ,,butt]s1 ,,v>i\s ,,diabetic1 #dej ,,cact9 7,,n[ ,,cactoid71 #cg ,cact9 7,! ,abbott ,laboratories7 & ,cact9a 7,sultan ,drug ,company71 ,! ,j\rnal1 ,sept4 #ba1 #aijg1 p4 #ajba2 ,m>* #ba1 #aijh1 p4 #ief2 ,april #d1 #aijh1 p4 #aadj2 ,aug4 #f1 #aiaj1 p4 #dee4 ,,cact9a1 #cf ,,cact9a ,,pillets1 #cg ,,cactus ,,gr&iflorus1 #cf ,cactus ,gr&iflorus1 ,! ,j\rnal1 ,sept4 #ba1 #aijg1 p4 #ajba2 ,jan4 #g1 #aiaa1 p4 #bf4 ,calcid9 ,abbott & ,calcid9 ,tablets 7,! ,abbott ,laboratories71 ,! ,j\rnal1 ,sept4 #g1 #aijg1 p4 #hfe2 ,reports ,*em4 ,lab41 #aiji1 p4 #g4 ,,calcreose1 #dj ,,call>d',s ,,prep>ations ,,= ,,diabetics1 #dej ,,calm9e1 #bhf ,,camph5ol1 #bhg ,,campho-,,ph5ique1 #dj1 #bje ,,campho-,,ph5ique ,,company1 #dj1 #db ,,campho-,,ph5ique ,,p[d]1 #da ,,canada ,,lancet1 ,,adv]tis+ ,,91 #bgi1 #cjj ,,canadian ,,m$ical ,,association ,,j\rnal1 ,,adv]tis+ ,,91 #cjj ,,canadian ,,practition] ,,& ,,review1 ,,adv]tis+ ,,91 #cjj ,,canc] ,,hospital 7,,kellam71 #dbf ,cannabis ,comp\nd1 ,syrup ( 7,pitman-,moore ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #afh4 ,captol 7,mlh5s ,kropff71 ,! ,j\rnal1 ,sept4 #aj1 #aiaj1 p4 #iei2 ,reports ,*em4 ,lab41 #aiaj1 p4 #gj4 ,,c>n9e1 #abc1 #abe1 #abh ,,c>n9e ,,company1 #abc ,,c>nrick1 ,g4 ,w41 ,,company1 #ahe1 #djc ,c>oid & ,ess5ce ( ,c>oid 7,mead1 ,johnson ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiad1 p4 #aji4 ,,c>panutr9e1 #acc ,casca-,aletris 7,pull5-,ri*>dson ,*emical ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #df4 ,,casc>ans 7,,bell71 #aed ,,casc>ets1 #dge ,,casoid ,,diabetic ,,prep>ations1 #ddi1 #dej ,cavibl5 7,a4 ,grimme71 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #agf4 ,c$ron ,se$1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #dj4 ,,cel]9a1 #dc ,,cell>ius ,,company1 #he ,cel]y & v>i\s ,elixirs ( ,cel]y 7,hance ,bros4 ,:ite1 ,nelson1 ,bak] ,co41 ,p>ke1 ,davis ,co41 ,ray ,*emical ,co41 ,smi?1 ,kl9e ,fr5* ,co41 ,f4 ,/e>ns ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #dj4 ,cellas9 7,mead ,johnson ,co471 ,! ,j\rnal1 ,sept4 #ab1 #aijh1 p4 #ica2 ,oct4 #cj1 #aiji1 p4 #adif2 ,reports ,c\ncil ,ph>m4 ,*em41 #aije-h1 p4 #aih2 #aiji1 p4 #aah4 ,,c]eo ,,soy ,,bean ,,gruel ,,fl\r1 #dej ,,*amaelirium ,,luteum1 #hd ,,*amb]la91 ,c4 ,s41 #ha ,,*amb]s1 ,,ar?ur ,,& ,,leslie ,t41 #adg ,,*amb]s1 ,j4 ,h4 ,,& ,m4 ,e41 #adf ,,*apoteaut',s ,,w9e1 #fj ,,*>lotte ,,m$ical ,,j\rnal1 ,,adv]tis+ ,,91 #ca1 #ce1 #dbb ,,*emis*e ,,fabrik ,,falk5b]g1 #he ,,*esebr\gh1 ,,rob]t ,a41 #afa ,,*icago ,,m$ical ,,record]1 ,,adv]tis+ ,,91 #ca ,,*9osol1 #bdh ,,*9osol ,,company1 #bf1 #bdh ,*iodra/is 7,h4 ,k4 ,wampole ,co471 ,*ionacea 7,nelson1 ,bak] ,co41 ,inc471 ,elixir ,*ionan?us ,comp\nd 7,ray ,*emical ,co471 & ,elixir ,*ionan?us 7,special7 7,p>ke1 ,davis ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #db4 ,,*ionia1 #cj ,,*loro-,,ph5ique1 #db ,,*ocolate1 ,,propriet>y ,,diabetic1 #dej ,,*olog51 #bhh ,*ologe/9 7,f4 ,h4 ,/rong ,co471 ,! ,j\rnal1 ,dec4 #aa1 #aiae1 p4 #bajh4 ,*romiac ,tablets 7,maltbie ,*emical ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #dd4 ,,cibilis ,,company1 #dgb ,,c9]>ia ,,m>itima1 #di ,cit>9 7,! ,bay] ,company1 ,inc471 ,! ,j\rnal1 ,feb4 #bj1 #aiae1 p4 #fhe2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiad1 p4 #ace4 ,,citrocoll1 #he ,,clausel1 ,,h5ry1 ,,co41 #bba ,clov] ,comp\nd1 ,syrup ,r$ 7,nelson1 ,bak] ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #dj4 ,,cocillana ,,comp\nd1 ,,syrup ,,(1 #cif ,cod ,liv] ,ext41 ,/e>ns' ,w9e (1 ) ,peptonate ( ,iron 7,fr$]ick ,/e>ns ,co474 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #agg4 ,,cod ,,liv] ,,oil ,,& ,,cod ,,liv] ,,oil ,,cordials1 ,,comp>ative ,,nutri5t ,,value ,,(1 #ddb ,cod-,liv] ,oil1 ,budwell's ,emulsion (1 ,nos4 #a & #b 7,budwell ,ph>macal ,co471 ,! ,j\rnal1 ,feb4 #bj1 #aiae1 p4 #fhd2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #ace4 ,,cod ,,liv] ,,oil ,,prep>ations1 #ea1 #eb1 #ed1 #eg1 #bhi1 #ddb ,coho%1 ,blue1 & ,fluidextract ,blue ,coho% ,comp\nd 7,p>ke1 ,davis ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #dj4 ,col*i-,me?yl ,capsules 7,h4 ,k4 ,wampole ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #afi4 ,,col*i-,,sal1 #eh ,,collyrium-,,wye?1 #bib ,,columbus ,,ph>macal ,,company1 #cdd ,,com> ,,co41 #dja ,comp\nd1 ,wat]bury's 7,wat]bury ,*emical ,co471 ,! ,j\rnal1 ,m>* #bj1 #aiae1 p4 #ajaf2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #ach4 ,condurango1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiaa1 p4 #ed4 ,,conley1 ,,william ,w41 #di ,,consolidat$ ,,color ,,& ,,*emical ,,works1 #cbh ,,copel&1 ,b4 ,f41 #bff ,corydalis ,comp\nd1 ,elixir 7,p>ke1 ,davis ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #dg4 ,,cosmol9e1 ,,liquid1 #afa ,coto & ,coto91 ,reports ,c\ncil ,ph>m4 ,*em41 #aiac1 p4 #ci4 ,,cotton-,,root ,,b>k1 #hd ,,c\drey1 ,h4 ,m41 #aai ,,cramp ,,b>k ,,comp\nd1 ,,fluid ,,extract ,,(1 #daj ,,crawley1 ,m41 #aai ,,crysmal91 #afa ,cuprase 79 8,*emo!rapy & ,tumors071 ,! ,j\rnal1 ,april #ag1 #aiae1 p4 #abhc2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #bh4 ,,cudahy ,,pack+ ,,company1 #dga1 #dgb ,cur>e & ,cur>91 ,! ,j\rnal1 ,jan4 #ae1 #aiaj1 p4 #bai2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiaj1 p4 #g4 ,,cypridol ,,capsules1 #ei ,cy/itis ,tablet 7,p>ke1 ,davis ,co41 ,smi?1 ,kl9e ,fr5* ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #de4 ,,cy/og51 ,,cy/og5 ,,ap]i5t1 ,,cy/og5-,,li?ia ,,& ,,cy/og5 ,,*emical ,,company1 #fj ,,cy/o-,,s$ative1 #fa ,,dad ,,*emical ,,company1 #acf ,damiana1 ,allan's ,comp\nd ,extract ( 7,allan-,pfeiff] ,*emical ,co471 ,! ,j\rnal1 ,july #ai1 #aiac1 p4 #baa4 ,,d&]9e1 #dgd ,,daniel1 ,,john ,b41 #ccb ,,daniel',s ,,conc5trat$ ,,t9cture ,,( ,,passiflora1 #aef1 #ccb ,,d>p91 #dg ,,dawson1 ,,james ,p41 #di ,,deel9e1 #afa ,,d5/on1 ,j4 ,c41 #bea ,,d5v] ,,m$ical ,,times ,,& ,,utah ,,m$ical ,,j\rnal1 ,,adv]tis+ ,,91 #ca1 #ce1 #di ,,detroit ,,m$ical ,,j\rnal1 ,,adv]tis+ ,,91 #cjj ,diabetic ,biscuit & ,fl\r & o!r ,foods1 ,jireh 7,jireh ,diabetic ,food ,company71 ,! ,j\rnal1 ,m>* #bb1 #aiac1 p4 #ibb1 & ,dec4 #ad1 #aiab1 p4 #bagd4 ,,diabetic ,,foods ,,(f]$ ,,= ,,sale ,,9 ,,! ,,unit$ ,,/ates1 #ddf ,dianol ,i1 ,dianol ,,ii & ,dianol ,,iii 7,kalle ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiac1 p4 #cd4 ,dia/os1 ,liquor 7,h4 ,k4 ,mul=d ,co471 ,! ,j\rnal1 ,feb4 #i1 #aijg1 p4 #ecc4 ,,diatuss91 #bic ,,digal51 #fh ,,dietetic ,,& ,,hygi5ic ,,gazette1 ,,adv]tis+ ,,91 #cdb ,,dige/ive ,,tablets1 ,,aromatic1 #bbi ,dige/ive ,tonic 7,truax1 ,gre5e ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #dd4 ,digitalis prep>ations1 propriet>y1 ,! ,j\rnal1 ,dec4 #d1 #aiae1 p4 #bjbd2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #hi4 ,digitalone 7,p>ke1 ,davis ,co471 ,! ,j\rnal1 ,june #ab1 #aiji1 p4 #aich2 ,dec4 #g1 #aiab1 p4 #bjgd2 ,jan4 #aa1 #aiac1 p4 #adc4 ,digitalysatum 7,e4 ,bis*(f ,co471 ,! ,j\rnal1 ,feb4 #ae1 #aiac1 p4 #dii2 ,jan4 #h1 #aiaf1 p4 #ace2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #ic4 ,,diorad91 #gc1 #dcf ,,dios ,,*emical ,,company1 #da1 #aci1 #adf ,,dioscorea ,,villosa1 #bjh ,dioscorea1 v>i\s elixirs ( 7,h4 ,k4 ,mul=d ,co41 ,p>ke1 ,davis ,co41 ,ray ,*emical ,co41 ,f4 ,/e>ns ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 pp4 #da1 #df4 ,,dioviburnia1 #aci1 #ada1 #daj ,,dioxog51 #dcf ,,diuret91 #bea ,diurol 7,h4 ,k4 ,mul=d ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #de4 ,,dodge1 ,,john ,l41 #aee ,dogwood1 ,fl[]+1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #da4 ,,dom9ion ,,m$ical ,,mon?ly1 ,,adv]tis+ ,,91 #cjj ,,d[d1 ,j4 ,,h5ry1 ,,& ,,d[d',s ,,phosphatomet]1 #dgf ,,drake',s ,,palmetto ,,comp\nd1 #dge ,,dubl9 ,,j\rnal ,,m$ical ,,sci5ce1 ,,adv]tis+ ,,91 #bgi ,duod59-,arm\r 7,arm\r ,co471 ,! ,j\rnal1 ,aug4 #d1 #aiae1 p4 #fci2 ,jan4 #ae1 #aiaf1 p4 #agh2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 pp4 #ii1 #aea4 ,dyspepsia ,comp\nd1 ,elixir 7,h4 ,k4 ,mul=d ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #dd4 ,dyspepsia1 ,elixir ,atonic1 ,ph5olat$ 7,wm4 ,s4 ,m]rell ,*emical ,company71 ,! ,j\rnal1 ,feb4 #i1 #aijg1 p4 #ecc4 ,,e*afolta1 #hj ,,e*9acea1 #gi1 #hj ,,e*itone1 #ha ,,e*tisia1 #ha ,,eclectic ,,m$ical ,,j\rnal1 ,,adv]tis+ ,,91 #ca1 #ce1 #di1 #cdb ,,ec?ol1 #hj1 #ha ,,eczema ,,lotion1 ,,dr4 ,,bradbury',s1 #bde ,edema ,tablet 7,p>ke1 ,davis ,co41 ,smi?1 ,kl9e ,fr5* ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 pp4 #da1 #de4 ,,edson1 ,,dr4 ,,cyrus1 #ccf ,,eim] ,,& ,,am5d1 #aac ,,el ,,z]nac ,,company1 #cdd ,eld]1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #da4 ,electro-,sel5ium 79 8,*emo!rapy & ,tumors071 ,! ,j\rnal1 ,april #ag1 #aiae1 p4 #abhc2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #bh4 ,,ell+wood',s ,,!rapeuti/1 ,,adv]tis+ ,,91 #ca1 #ce ,emulsio ,m9]ole9 & ,emulsio ,ph5-,oleum 7,t4 ,r4 ,d4 ,b>se ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #afi4 ,endot9 7,morg5/]n ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiad1 p4 #acf4 ,enesol 7,f\g]a ,co471 ,! ,j\rnal1 ,july #bf1 #aiac1 p4 #bic4 ,,ent]onol ,,& ,,ent]onol ,,company1 #bid ,eos9-,sel5ium 79 8,*emo!rapy & ,tumors071 ,! ,j\rnal1 ,april #ag1 #aiae1 p4 #abhc2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #bh4 ,,ep9ephr91 ,,"n1 ,,v]sus ,,! ,,"n ,,adr5al91 #ded ,episan 7,gaynor-,bag/ad ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #afd4 ,,ergoapiol1 #hb ,ergone 7,p>ke1 ,davis ,co471 ,! ,j\rnal1 ,oct4 #g1 #aiaa1 p4 #abaa2 ,oct4 #ad1 #aiaa1 p4 #acjb4 ,ergotole 7,%>p ,dohme71 ,! ,j\rnal1 ,oct4 #g1 #aiaa1 p4 #abaa2 ,oct4 #ad1 #aiaa1 p4 #acjb4 ,,erpiol 7,,dr4 ,,s*rad]71 #hc ,eryngo1 ,wat]1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #dg4 ,,e/ill1 ,,floyd1 #ah ,,etna ,,*emical ,,company1 #bbe1 #cce ,eunatrol 7,c4 ,bis*(f ,co471 ,! ,j\rnal1 ,feb4 #bb1 #aijh1 p4 #fbg4 ,,eusoma1 #hj ,eusoma 7,eusoma ,ph>maceutical ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #ch4 ,,eusoma ,,ph>maceutical ,,company1 #ha ,,expurgo ,,anti-,,diabetes ,,& ,,expurgo ,,manufactur+ ,,company1 #bii ,,expurgo ,,lapis1 #dci ,expurgo ,lapis 7,expurgo ,manufactur+ ,co471 ,! ,j\rnal1 ,nov4 #h1 #aiac1 p4 #agcc4 ,,exurg9e1 #cdd ,,false ,,unicorn1 #hd ,,f>b5fabrik5 ,,( ,,elb]feld ,,company1 #caa1 #dad ,febrisol 7,tild5 ,co471 ,! ,j\rnal1 ,june #bi1 #aiab1 p4 #bjdc4 ,febri-,tone 7,ar?ur ,vet] ,co471 ,! ,j\rnal1 ,feb4 #a1 #aijh1 p4 #cgi4 ,,fell[s' ,,syrup ,,( ,,hypophosphites1 #dcf ,,f]buson ,,glut5 ,,bread1 #dej ,f]m5lactyl 7,anglo-,am]ican ,ph>macal ,co41 ,ltd471 ,! ,j\rnal1 ,jan4 #cj1 #aiji1 pp4 #cgb1 #cig4 ,f]ric ,ars5ite1 ,soluble1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #cj4 ,figwort1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #db4 ,filud9e 7,geo4 ,j4 ,wallau1 ,inc471 ,! ,j\rnal1 ,sept4 #ah1 #aiae1 p4 #ajde2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #aef4 ,,fl\rs1 ,,v>i\s ,,diabetic1 #ddi1 #dej ,,foods1 ,,diabetic1 ,,(f]$ ,,= ,,sale ,,9 ,,! ,,unit$ ,,/ates1 #ddf ,,foods1 ,,m$ic9al1 #aca ,,=mam9t1 #cjc ,=mam9t 7,a4 ,wulf+ ,co471 ,! ,j\rnal1 ,aug4 #bh4 #aiae1 p4 #haf2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #fd4 ,=mid9 7,p>ke1 ,davis ,co471 ,! ,j\rnal1 ,sept4 #e1 #aijh1 p4 #hah2 ,reports ,c\ncil ,ph>m4 ,*em41 #aije-h1 p4 #aib4 ,,=murol1 #he ,,=tossan1 #agh ,,fossil9e1 ,,liquid1 #afa ,,f\g]a1 ,e4 ,,co41 #aj1 #bg1 #eh1 #ei1 #aae1 #abc ,,franco-,,am]ican ,,f]m5t ,,company1 #abj ,,fras] ,,tablet ,,company1 #bcb ,,fraud1 ,,great ,,am]ican1 ,,& ,,ph>maceutical ,,manufactur]s1 #dgd ,,fr$]ick1 ,,purdue1 ,,company1 #ajj ,fri$mann's ,vacc9e 7,/&>d ,di/ribut+ ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiad1 p4 #acf4 ,fr+e ,tree1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #db4 ,,fromm',s ,,diabetic ,,breads ,,& ,,*ocolate1 #dej ,fros/'s ,blaud ,capsules & ,fros/'s ,blaud1 ,ars5ic & ,/ry*n9e ,capsules 7,c4 ,e4 ,fros/ ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #afd4 ,g4 ,g4 ,ph5oleum ,dis9fectant 7,g4 ,g4 ,*emical ,co41 ,inc471 ,! ,j\rnal1 ,jan4 #cj1 #aiae1 p4 #def2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #aca4 ,galactagogue 7,eli ,lilly ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #dc4 ,,gamble1 ,d4 ,e41 #aai ,,g>dn]1 ,r4 ,w41 #caj ,,g>dn]-,,b>ada ,,*emical ,,company1 #bef ,,g>dn]',s ,,syrup ,,( ,,hydriodic ,,acid1 #ig ,,ga/rog5 ,,tablets1 #hg ,gelsem9e ,hydro*lorid & ,gelsem99e1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiaa1 p4 #eg4 ,,g5]al ,,drug ,,company1 #cbh ,g5itone 7,wm4 ,s4 ,m]rell ,*emical ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #dd4 ,,geol9e1 ,,liquid1 #afa ,,g]man ,,c\ncil ,,on ,,ph>macy ,,& ,,*emi/ry1 #dei ,,g]man ,,propag&a ,,= ,,re=m1 #deh ,,g]miletum1 #aci1 #adc ,,g]o1 ,,l\is1 ,,ltd41 #gd ,,getwell ,,tablets1 #dgf ,g9s5g1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #db2 ,! ,j\rnal1 ,oct4 #bd1 #aiad1 p4 #adhf4 ,g9s5g ,comp\nd1 ,elixir 7,h4 ,k4 ,mul=d ,co471 & ,g9s5g ,comp\nd 7,special71 ,elixir 7,p>ke1 ,davis ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #db4 ,,glasg[ ,,m$ical ,,j\rnal1 ,,adv]tis+ ,,91 #bgi ,,glid9e1 #ddi ,glid9e 7,m5ley ,james71 ,! ,j\rnal1 ,june #bh1 #aiac1 p4 #bjcg4 ,globeol 7,geo4 ,j4 ,wallau1 ,inc471 ,! ,j\rnal1 ,sept4 #ah1 #aiae1 p4 #ajdf2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #aeg4 ,,glut5 ,,products1 ,,v>i\s1 ,,= ,,diabetic ,,use1 #dej ,glutol-,s*lei* 7,s*]+ ,glatz71 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #agj4 ,,glyc]91 ,,m9]al1 #afa ,glyc]9e ,tonic ,comp41 ,gray's 7,purdue ,fr$]ick ,co471 ,! ,j\rnal1 ,july #aj1 #aiae1 p4 #ahi2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #ef4 ,glyc]o-,leci?91 ,pill 7,we/]field ,ph>macal ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #agj4 ,glyc]ole ( ,leci?9 7,fair*ild ,bros4 ,fo/]71 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #abc4 ,,glyco1 #afa ,,glyco-,,h]o91 ,,smi?1 #hh ,,glycol9e1 #afa ,,glyco-,,?ymol9e1 #ib ,,glycozone1 #ie ,,glymol1 #afa ,goat's ,rue1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #db4 ,,gom5ol1 #cjd ,gonococcide 7,cox ,*em4 ,co471 ,! ,j\rnal1 ,aug4 #bd1 #aijg1 p4 #gjh4 ,,gordon1 #ah ,,gossyp91 #hd ,,gr& ,,prix ,,& ,,gold ,,m$als ,,= ,,sale1 #dfb ,gray's ,glyc]9e ,tonic ,comp4 7,purdue ,fr$]ick ,co471 ,! ,j\rnal1 ,july #aj1 #aiae1 p4 #ahi2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #ef4 ,,gris>d1 ,a4 ,f41 ,b4 ,a41 ,,dr4 ,,john ,p4 ,,& ,,dr4 ,,john ,w41 #ah ,guaial9 7,organic ,*emical ,mfg4 ,co471 ,! ,j\rnal1 ,sept4 #e1 #aijh1 p4 #hah2 ,may #h1 #aiji1 p4 #aeaa2 ,reports ,c\ncil ,ph>m4 ,*em41 #aije-h1 p4 #aff2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiji1 p4 #gf4 ,gu>ana & ,cel]y1 v>i\s ,elixirs ( 7,hance ,bros4 ,:ite1 ,p>ke1 ,davis ,co41 & ,ray ,*emical ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #dj4 ,,gubb1 ,,alfr$ ,s41 #dcf ,,gude',s ,,pepto-,,mangan1 #aei ,,gum ,,glut5 ,,breakfa/ ,,food1 #dej ,h-,m-,c2 see ,hyosc9-,morph9 ,cact94 ,,hagee',s ,,cordial ,,( ,,cod-,,liv]-,,oil1 #ea1 #bhi1 #ddc ,hair ,cap ,moss1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #dc4 ,,hammond1 ,g4 ,h41 ,,company1 #dgb ,,hance ,,bros1 ,,& ,,:ite1 #age ,,hanson1 ,,edw>d ,f41 #dgf ,,hayd5',s ,,viburnum ,,comp\nd1 #bah1 #dji ,,hayd51 ,w4 ,r41 #bah ,,heada*e 8,,cures01 #cje ,,heada*e ,,p[d]s1 ,,koehl]',s1 #aj 8,,heal? ,,food0 ,,diabetic ,,prep>ation1 #dej ,,hect9e1 #cjh ,,helonias ,,dioica1 #hd ,helonias1 elixirs & fluidextracts (1 v>i\s 7,hance ,bros4 ,:ite1 ,h4 ,k4 ,mul=d ,co41 ,p>ke1 ,davis ,co41 ,ray ,*emical ,co4 & ,smi?1 ,kl9e ,fr5* ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 pp4 #da1 #df4 ,helon9 ,comp41 ,mi/4 7,s*lott]beck ,foss71 ,! ,j\rnal1 ,dec4 #ah1 #aiae1 p4 #bahf4 ,,hemo1 #cai1 #cbb ,,hemorrhoidal ,,suppositories1 ,,anusol1 #bbg1 #bhj ,,h5ry ,,ph>macal ,,company1 #aih ,,h]b9e1 #bje ,,h]rick',s ,,pills1 #dc1 #bje ,hexa-co-sal-9 7,hexa-,co-,sal-,9 ,company71 ,! ,j\rnal1 ,oct4 #b1 #aiae1 p4 #abjc2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #aei4 ,hex-a-li? 7,smi?-,dorsey ,company71 ,! ,j\rnal1 ,feb4 #ad1 #aiad1 p4 #eee4 ,,hille1 ,h41 #bhd ,,h(fmann-,,la ,,ro*e ,,*emical ,,works1 #fh1 #beb ,,hoge1 ,w4 ,m41 #cbh ,,hord ,,sanit>ium1 #def ,horse ,nettle1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #dc4 ,,hospital ,,bullet9 ,,( ,,! ,,univ]sity ,,( ,,m>yl&1 ,,adv]tis+ ,,91 #ce ,,h[ell1 ,h4 ,b4 ,,co41 ,,ltd41 #cbf ,,huntley ,,& ,,palm]',s ,,akoll ,,biscuit1 #ddi ,,hurley1 ,h4 ,o41 #cea ,hydragog9 7,c4 ,bis*(f ,co471 ,! ,j\rnal1 ,jan4 #bg1 #aijf1 p4 #bhh2 ,! ,j\rnal1 ,sept4 #d1 #aiae1 p4 #hid2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #aed4 ,hydrangea & ,li?ia1 ,elixir 7,hance ,bros4 ,:ite71 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #de4 ,hydrangea1 ,li?iat$ 7,lamb]t ,ph>macal ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #db4 ,,hydra/is ,,& ,,cramp ,,b>k ,,comp\nd1 ,,hydra/is ,,& ,,viburnum ,,comp\nd1 ,,elixir ,,(1 #daj ,,hydriodic ,,acid1 ,,g>dn]',s ,,syrup ,,(1 #ig ,,hydrocyanate ,,( ,,iron1 ,,tild51 #bce ,hydrole9e 7,*>les ,n4 ,critt5ton ,company71 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #aga4 ,hydron 7,wm4 ,s4 ,m]rell ,*emical ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #dd4 ,,hydronaph?ol1 #cjh ,hydrops9 7,ern/ ,bis*(f ,co471 ,! ,j\rnal1 ,jan4 #h1 #aiaf1 p4 #ace2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #id4 ,,hydrozone1 #if1 #cji ,,hymosa1 #bch1 #cbc ,hyosc9-,morph9 ,cact9 7n[ ,hyosc9-,morph9-,cactoid7 7,abbott ,laboratories71 ,! ,j\rnal1 ,dec4 #ba1 #aijg1 p4 #bajc4 ,,hyp]ol1 #ajj ,,hypophosphite ,,fallacy1 #dfd ,,hypophosphites1 ,,fell[s' ,,syrup ,,(1 #dcf ,,hypoqu9idol1 #caj ,i*?ynate 7,mall9ckrodt ,*emical ,works71 ,reports ,*em4 ,lab41 #aiab1 p4 #aaj4 ,,indianapolis ,,m$ical ,,j\rnal1 ,,adv]tis+ ,,91 #ca1 #ce1 #cjj ,,indigo1 ,,wild1 #bji ,,+luv91 #aja ,,+raham1 ,c4 ,w41 #bhe ,int]ol 7,van ,horn ,sawtell71 ,! ,j\rnal1 ,july #aj1 #aiae1 p4 #age4 ,,int]national ,,j\rnal ,,( ,,surg]y1 ,,adv]tis+ ,,91 #ca1 #di1 #cdb1 #dbi ,,int]/ate ,,m$ical ,,j\rnal1 ,,adv]tis+ ,,91 #di ,,inte/9al ,,antiseptic ,w-,a41 #ajc ,intrav59 ,p-,h 7,intrav59 ,products ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #abj4 ,,intrav5\s ,,products ,,company1 #bab1 #bad ,,intrav5\s ,,solution1 ,,bann]man',s1 #aje ,,iodalia1 #ajf ,,iodex1 #ajg ,,iodia1 #ajh ,iod9 ,petrog5 7,john ,wye? ,bro471 ,! ,j\rnal1 ,nov4 #cj1 #aiab1 p4 #aiib4 ,iod9e1 ,burnham's ,soluble & ,burnham's ,soluble ,iod9e ,tablets1 #aaj1 #bcc ,iodival 7,knoll ,co471 ,! ,j\rnal1 ,m>* #d1 #aiaa1 p4 #fhe4 ,iodo-,bromide ( ,calcium ,comp4 8,)\t ,m]cury0 & 8,) ,m]cury10 ,elixir ( 7,tild5 ,co471 ,! ,j\rnal1 ,nov4 #f1 #aiae1 p4 #affb2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #afj4 ,iodomu? 7,organic ,*emical ,mfg4 ,co471 ,! ,j\rnal1 ,sept4 #e1 #aijh1 p4 #hah2 ,may #h1 #aiji1 p4 #aeaa2 ,reports ,c\ncil ,ph>m4 ,*em41 #aije-h1 p4 #aff2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiji1 p4 #ge4 ,,iodonucleoid1 #caj ,,iodotone1 #aac ,,iodovasog51 #djh ,iodum-,mill] & ,iod-,izd-,oil1 ,mill]'s 7,iodum-,mill] ,co471 ,! ,j\rnal1 ,oct4 #b1 #aiae1 p4 #abjb2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #gf4 ,,iosal9e1 #aac ,,iosal9e ,,company1 #aad ,,i[a ,,m$ical ,,j\rnal1 ,,adv]tis+ ,,91 #ce1 #cjj ,,iridium 7,,m$ic9al71 #cab ,,iron1 ,,hydrocyanate ,,(1 ,,tild51 #bce ,iron ,solution = ,intrav5\s ,!rapy--,p]k9s & ,ross 7,p]k9s & ,ross71 ,! ,j\rnal1 ,nov4 #ad1 #aiad1 p4 #aggh2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiad1 p4 #abe4 ,,iron ,,tropon1 #cac ,isopral 7,f>b5fabrik5 ( ,elb]feld ,co471 ,! ,j\rnal1 ,aug4 #h1 #aijh1 p4 #dhg2 ,reports ,c\ncil ,ph>m4 ,*em41 #aije-h1 p4 #aai4 ,j>oma 7,j>oma ,company71 ,! ,j\rnal1 ,sept4 #b1 #aiaa1 p4 #hce2 ,reports ,*em4 ,lab41 #aiac1 p4 #ajc4 ,,j>os1 ,a4 ,l41 #bbe ,jireh ,diabetic 7,diatetic7 ,biscuit1 ,fl\r & o!r foods 7,jireh ,diabetic ,food ,company71 ,! ,j\rnal1 ,m>* #bb1 #aiac1 p4 #ibb2 ,dec4 #ad1 #aiab1 p4 #bagd4 ,,jireh ,,diabetic 7,,diatetic7 ,,food ,,products1 #ddi1 #dej ,,jireh ,,diabetic ,,food ,,company1 #dea ,,johns1 ,l4 ,d41 ,,company ,,& ,,dr4 ,,john',s ,,tablets1 #aed ,,johnson ,,& ,,johnson1 #bhg ,,j\rnal ,,( ,,n]v\s ,,& ,,m5tal ,,diseases1 ,,adv]tis+ ,,91 #ce ,,j\rnal ,,tropical ,,m$ic9e ,,& ,,hygi5e1 ,,adv]tis+ ,,91 #bgi ,jubol 7,geo4 ,j4 ,wallau1 ,inc471 ,! ,j\rnal1 ,aug4 #ad1 #aiae1 p4 #fci2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #aeb4 ,jugl&91 ,! ,j\rnal1 ,nov4 #ac1 #aiji1 p4 #afee2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiji1 p4 #ace4 ,,kais]1 ,,max1 #dfb ,,kal>i ,,batons1 #ddi1 #dej ,,kal>i ,,biscuit1 #ddi ,,kansas ,,city ,,m$ical ,,record1 ,,adv]tis+ ,,91 #bif ,,ka?>mon ,,*emical ,,company1 #ea ,,keel]1 ,,claude ,c41 #dcf ,kefilac 7,kefilac ,co471 ,! ,j\rnal1 ,jan4 #cj1 #aiji1 pp4 #cgb1 #cig4 ,,kellam ,,canc] ,,hospital1 #dbf ,,kellogg',s ,,diabetic ,,products1 #ddi1 #dej ,,k5n$y',s ,,p9us ,,canad5sis1 ,,light ,,& ,,d>k1 #dg ,,k5n]1 ,,rob]t ,c41 #cjj ,k]at91 ,reports ,c\ncil ,ph>m4 ,*em41 #aiaa1 p4 #eh4 ,k9azyme 7,g4 ,w4 ,c>nrick ,co471 ,! ,j\rnal1 ,nov4 #a1 #aiac1 p4 #afdi4 ,,klip/e91 ,a41 ,,co41 #agh ,,knoll ,,co41 #beb ,,kn[lton ,,d&]9e ,,company1 #dgd ,,koe*l1 ,,victor1 ,,co41 #ace1 #cbh ,,koehl]',s ,,heada*e ,,p[d]s1 #aj ,kola ,comp\nd1 ,elixirs 7,h4 ,k4 ,mul=d ,co41 ,p>ke1 ,davis ,co4 & ,ray ,*emical ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #dj4 ,kolynos 7,kolynos ,co471 ,! ,j\rnal1 ,nov4 #ae1 #aiac1 p4 #ahab4 ,,komm&antan ,,apo!ke1 #ccd ,koyol 7,koyol ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #agb4 ,,kress ,,& ,,ow5 ,,company1 #ib ,,kutn[ ,,bro!rs1 ,,ltd41 ,,& ,s4 ,,kutn[1 #caf ,,kutn[',s ,,p[d]1 #cad ,kutn['s ,p[d] 7,kutn[ ,bros471 ,! ,j\rnal1 ,nov4 #i1 #aijg1 p4 #afai4 ,,labord9e1 #aae ,,labord9e ,,ph>macal ,,company1 #aaf1 #aai ,,lactobacill9e1 #abj ,lactone 7,p>ke1 ,davis ,co471 ,! ,j\rnal1 ,jan4 #cj1 #aiji1 pp4 #cgb1 #cig4 ,,lactopept9e1 #aba ,lactopept9e & ,elixir ,lactopept9e 7,new ,york ,ph>macal ,association71 ,! ,j\rnal1 ,oct4 #bc1 #aiae1 p4 #adgg2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #gi4 ,,lactuc>ium1 ,,aub]gi]',s ,,syrup ,,(1 #cii ,,la9e ,,*emical ,,company1 #aif ,,lancet1 ,,adv]tis+ ,,91 #bgi ,,lancet-,,cl9ic1 ,,adv]tis+ ,,91 #ca1 #cdb ,,l>yngoscope1 ,,adv]tis+ ,,91 #ce ,,laxaph51 #cdd ,,lax9e1 #cdd ,,laxo?al5 ,,tablets1 #cdd ,lecibr9 7,fair*ild ,bros4 ,fo/]71 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #abc4 ,leci?91 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #abb4 ,leci?9 ,solution 7,fair*ild ,bros4 ,fo/]71 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #abc4 ,leci?ol 7,arm\r ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #abc4 ,,lehn ,,& ,,f9k1 #dad1 #dae ,lettuce ,calmative 7,nelson1 ,bak] ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #dc4 ,lettuce1 ,wild1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #dc4 ,,lewis1 ,,ar?ur ,g41 #dcc ,,lewis1 ,,h]b]t ,c41 #dcd ,,libby1 ,,mcneil ,,libby1 #dga ,,lilly1 ,,eli1 ,,co41 #acc1 #aie1 #daj ,,lipp9cott',s ,,magaz9e1 ,,adv]tis+ ,,91 #dai ,,liquid ,,peptones1 #acc ,,liquid ,,petrolatum1 #afa ,,liquid ,,taka-,,dia/ase1 #fb ,,liquozone1 #dac ,li?ia & ,broom ,corn ,comp\nd1 ,elixir 7,p>ke1 ,davis ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #ci4 ,li?ia & ,hydrangea1 ,elixirs 7,p>ke1 ,davis ,co41 ,ray ,*emical ,co4 & ,smi?1 ,kl9e ,fr5* ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #de4 ,li?iat$ ,sorghum ,comp\nd 7,%>p ,dohme71 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #ci4 ,,li?ia ,,wat]1 ,,buffalo1 #dfg ,,littleton1 ,j4 ,m4 1 #ah ,liv] ,leaf1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #dc4 ,,loeb',s ,,import$ ,,glut5 ,,fl\r1 #dej ,,l\isville ,,mon?ly ,,j\rnal ,,( ,,m$ic9e ,,& ,,surg]y1 ,,adv]tis+ ,,91 #ca1 #ce1 #cjj ,,l\isville ,,ph>macal ,,works1 #daj ,,luyties' ,,homeopa?ic ,,ph>macy ,,company1 #ej1 #bdj1 #cbc ,,lymph ,,comp\nd ,r-,h1 #cag ,,lyn*1 ,j4 ,j4 1 #ah ,lys(orm & ,lys(orm1 ,crude 7,lys(orm ,gesells*aft71 ,! ,j\rnal1 ,nov4 #ba1 #aiad1 p4 #ahgj2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiad1 p4 #abf4 ,,lysol1 #cah ,,magi/ral ,,*emical ,,company1 #cbh ,,maign5 ,,antiseptic ,,p[d] ,,& ,,maign5 ,,in/itute ,,= ,,! ,,/udy ,,( ,,bact]ial ,,diseases1 #ai ,,maign51 ,p4 ,j4 ,a4 1 #bj ,maizav5a 7,william ,s4 ,m]rell ,*emical ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #dd4 ,,maiz99 ,,comp\nd1 #bdi ,,maizo-,,li?ium1 #aih1 #bjc ,,mall9ckrodt ,,*emical ,,works1 #aai1 #beb1 #dae ,malt ,extract ) ,peps9 & ,pancreat9 7,wm4 ,s4 ,m]rell ,*emical ,co41 ,p>ke1 ,davis ,co471 ,! ,j\rnal1 ,feb4 #i1 #aijg1 p4 #ecc4 ,malt1 ,williams' ,syrup ( 7,am]ican ,malt ,extract ,co471 ,! ,j\rnal1 ,sept4 #d1 #aiae1 p4 #hie2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #aee4 ,,maltbie ,,*emical ,,company1 #dj ,,malt$ ,,beef-,,peptone1 #cai ,,malt$ ,,milk1 #cai ,manaca & v>i\s manaca prep>ations 7,hance ,bros4 ,:ite1 ,william ,s4 ,m]rell ,*emical ,co41 ,h4 ,k4 ,mul=d ,co41 ,nelson1 ,bak] ,co41 ,p>ke1 ,davis ,co41 ,pull5-,ri*>dson ,*emical ,co41 ,ray ,*emical ,co41 ,%>p ,dohme1 ,smi?1 ,kl9e ,fr5* ,co41 ,f4 ,/e>ns ,co4 & ,truax1 ,gre5e ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 pp4 #dc1 #dd4 ,,manola1 #cbc ,,manola ,,*emical ,,company1 #ej1 #bdj1 #cbc ,,m>*&1 ,,*>les1 #ie1 #cji ,,m>cy ,,company1 #baf1 #cdd ,,m>iani ,,co4 ,,& ,,m>iani',s ,,w9e1 #bba ,m>i5bad ,tablets 7,j4 ,sieke71 ,! ,j\rnal1 ,july #ah1 #aijh1 p4 #bcg4 ,,m>malade1 ,,casoid ,,sug>less1 #ddi ,,m>mola1 #cdh ,,m>yl& ,,m$ical ,,j\rnal1 ,,adv]tis+ ,,91 #ca1 #ce ,,massa*usetts ,,m$ical ,,j\rnal1 ,,adv]tis+ ,,91 #ce1 #di1 #cjj ,matico ,comp\nd1 ,elixir 7,p>ke1 ,davis ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #de4 ,,mayfield ,,m$ic9e ,,mfg4 ,,company1 #dc ,,mckesson ,,& ,,robb9s1 #bha1 #dja ,,meat ,,extracts ,,& ,,meat ,,juices1 #abc1 #dgj ,,m$ical ,,brief1 ,,adv]tis+ ,,91 #ca1 #ce1 #di1 #cjj ,,m$ical ,,c5tury1 ,,adv]tis+ ,,91 #di1 #cdb ,,m$ical ,,c\ncil1 ,,adv]tis+ ,,91 #di ,,m$ical ,,=tnightly1 ,,adv]tis+ ,,91 #ca1 #cjj ,,m$ical ,,h]ald1 ,,adv]tis+ ,,91 #ca1 #ce1 #cjj ,,m$ical ,,j\rnals ,,& ,,! ,,great ,,am]ican ,,fraud1 #dbf ,,m$ical ,,j\rnal ,,adv]tis+1 #dbb ,,m$ical ,,press ,,& ,,circul>1 ,,adv]tis+ ,,91 #bgi ,,m$ical ,,record1 ,,adv]tis+ ,,91 #ca1 #cjc1 #cjd1 #cdb ,,m$ical ,,review1 ,,adv]tis+ ,,91 #ce1 #cjj ,,m$ical ,,review ,,( ,,reviews1 ,,adv]tis+ ,,91 #ca1 #ce1 #di1 #cjj1 #cjd ,,m$ical ,,s5t9el1 ,,adv]tis+ ,,91 #ca1 #ce1 #di ,,m$ical ,,/&>d1 ,,adv]tis+ ,,91 #ca1 #ce1 #di1 #cjj1 #cdb ,,m$ical ,,summ>y1 ,,adv]tis+ ,,91 #ca1 #cjj ,,m$ical ,,times1 ,,adv]tis+ ,,91 #ca1 #ce1 #aca1 #cjj1 #dbd1 #dbf1 #dcj1 #dch ,,m$ical ,,_w1 ,,adv]tis+ ,,91 #ca1 #ce1 #aca ,,m$ic9al ,,foods1 #aca ,m$-,o-,l9 7,wav]ly ,oil ,works ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #agb4 ,,mei/]1 ,,lucius ,,brun+1 #ace ,,memphis ,,m$ical ,,mon?ly1 ,,adv]tis+ ,,91 #ce ,,m5ley ,,& ,,james1 ,,ltd41 #ajg ,,m]ck ,,co41 #beb1 #caa1 #dae ,,m]ck',s ,,ar*ives1 ,,adv]tis+ ,,91 #ce ,,m]col1 #cbf ,m]cury ,sozoiodolate & ,m]cury ,sozoiodolate ,solution1 ,! ,j\rnal1 ,feb4 #ac1 #aiji1 p4 #egc4 ,,m]rell1 ,,wm4 ,s41 ,,*emical ,,co41 #ha1 #hc1 #acc1 #bca ,,metcalf',s ,,diabetic ,,products1 #dej ,,me?yl ,,salicylate ,,o9tm5t1 #bfg ,me?yl-,santal 7,h4 ,k4 ,mul=d ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #agc4 ,,metropolitan ,,ph>macal ,,co41 #ahh ,,metz1 ,,h]man ,a41 #cbh ,,mey]1 ,,dr4 ,h4 ,f4 ,c41 ,,& ,,mey]',s ,,blood ,,purifi]1 #hj ,,micajah1 ,,co41 #bda1 #bdc ,,micajah',s ,,m$icat$ ,,ut]9e ,,waf]s1 #bdj ,,microbe ,,kill]1 ,,radam',s1 #dac ,,midol1 #cbg ,,migra991 #ace ,,milk1 ,,sug>-,,free1 #ddi ,mill]'s ,iod-,izd-,oil 7,iodum ,mill] ,co471 ,! ,j\rnal1 ,oct4 #b1 #aiae1 p4 #abjb2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #gg4 ,,milwaukee ,,m$ical ,,j\rnal1 ,,adv]tis+ ,,91 #bif ,,m9]al ,,oil1 ,,m9]al ,,glyc]9e1 #afa ,mi/4 ,helon9 ,comp4 7,s*lott]beck ,foss71 ,! ,j\rnal1 ,dec4 #ah1 #aiae1 p4 #bahf4 ,mit*ella ,comp\nd 7,dr4 ,j4 ,h4 ,dye ,m$ical ,in/itute71 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 pp4 #da1 #df4 ,,miz]1 ,,blake ,v41 ,,& ,,miz] ,,sanatorium1 #deg ,,mon?ly ,,cyclop$ia ,,& ,,m$ical ,,bullet91 ,,adv]tis+ ,,91 #ce ,,morse1 ,,will>d ,h41 #dcf ,,mosqu]a-,,julia ,,food ,,co41 #dgb ,,"m',s ,,cordial1 #daj ,"m's ,cordial 7,eli ,lilly ,co41 ,ray ,*emical ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #df4 ,mo!rwort1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #dd4 ,,mu-,,col ,,& ,,mu-,,col ,,co4 7,,inc471 #cbi ,,mul=d1 ,h4 ,k4 ,,co41 #aic1 #bcj1 #bfg1 #daj ,,mull]',s ,,tomatoes ,f,r ,,diabetik]1 #dej ,mu?ol 7,demu?'s ,laboratories71 ,! ,j\rnal1 ,july #aj1 #aiae1 p4 #age4 ,n>coph9 7,m]ck & ,co471 ,! ,j\rnal1 ,nov4 #ba1 #aiad1 p4 #ahgb4 ,,n>k9e1 #cbi ,,nas*]1 ,i4 ,l41 #dgi ,,na%ville ,,j\rnal ,,( ,,m$ic9e ,,& ,,surg]y1 ,,adv]tis+ ,,91 #ca1 #ce ,,na%ville ,,sanit>ium ,,diabetic ,,food ,,products1 #ddi1 #dej ,,nelson ,,bak] ,,co41 #bfg1 #daj ,nephrit9 7,re$ ,c>nrick ,co471 ,! ,j\rnal1 ,oct4 #e1 #aijg1 p4 #aaih2 ,reports ,c\ncil ,ph>m4 ,*em41 #aije-h1 p4 #gi4 ,nephroson 7,william ,s4 ,m]rell ,*emical ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 pp4 #ci1 #de4 ,,n]ve ,,vitaliz]1 ,,:eel]',s1 #daa ,,neuralg9e1 #dge ,,neurilla1 #acf ,neuro-,leci?9-,abbott 7,abbott ,laboratories71 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #abc4 ,neuroca9e 7,s*ieffel9 ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #agc4 ,,neuros9e1 #aci1 #adj ,,neutralol1 #afa ,,new ,,orleans ,,m$ical ,,& ,,surgical ,,j\rnal1 ,,adv]tis+ ,,91 #ca1 #ce ,,new ,,york ,,heal? ,,j\rnal1 #dcc ,,new ,,york ,,in/itute ,,( ,,physicians ,,& ,,surgeons1 #dge ,,new ,,york ,,m$ical ,,j\rnal1 ,,adv]tis+ ,,91 #ca1 #cjc1 #cjd1 #cdb ,,new ,,york ,,ph>maceutical ,,association1 #aba ,,noitol1 #bde ,,norwi* ,,ph>macal ,,co41 #bed1 #bei ,nose-,ions 7,nose-,ions ,company71 ,! ,j\rnal1 ,dec4 #d1 #aiae1 p4 #bjbf4 ,,n\rry ,,w9e1 #aae ,nujol 7,/&>d ,oil ,co4 ( ,new ,j]sey71 ,! ,j\rnal1 ,july #aj1 #aiae1 p4 #age4 ,,nurito1 #cbg1 #cbh ,,nutri5t ,,w9e ,,( ,,beef ,,peptone1 #acc ,,nutriola ,,co41 #dge ,,nutritive ,,liquid ,,peptone1 #acc ,,nut ,,products1 ,,v>i\s ,,diabetic1 #ddi1 #dej ,o-,p-,c ,,susp5sory1 #dcf ,oats1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #dd4 ,,od ,,*emical ,,co41 #ahb ,,old ,,dom9ion ,,j\rnal ,,( ,,m$ic9e ,,& ,,surg]y1 ,,adv]tis+ ,,91 #aca ,,oleum ,,gabianum1 #afa ,,olo1 #afa ,,orange9e1 #aj ,,or*itic ,,fluid ,,tablets1 #cag ,orsudan 7,burr\ghs1 ,wellcome ,co471 ,! ,j\rnal1 ,april #af1 #aiaj1 p4 #acbc4 ,,oxy*lor9e ,,& ,,oxy*lor9e ,,*emical ,,co41 #adg1 #bfa ,oxyd5dron ,comp\nd1 ,fluidextract 7,nelson1 ,bak] ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 pp4 #dc1 #de4 ,,oxydonor1 #dai ,oxynt9 7,fair*ild ,bro!rs ,fo/]71 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #agd4 ,,oxytonic1 #dac ,,pacific ,,m$ical ,,j\rnal1 ,,adv]tis+ ,,91 #ca1 #bgi1 #cdb ,palmetto ,comp\nd 7,william ,s4 ,m]rell ,*em4 ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #dd4 ,,palpebr9e1 #aci1 #ade ,,pam-,,ala1 #adi ,,pam-,,ala ,,co41 #aej ,,pancreat9 ,,& ,,peps9 ,,mixtures1 #aeg1 #bbi ,pancreat9 & peps9 prep>ations1 v>i\s 7,eli ,lilly ,co41 ,h4 ,k4 ,mul=d ,co41 ,p>ke1 ,davis ,co41 ,%>p ,dohme1 ,smi?1 ,kl9e ,fr5* ,co41 ,f4 ,/e>ns ,co4 & ,william ,r4 ,w>n] ,co471 ,! ,j\rnal1 ,feb4 #i1 #aijg1 p4 #ecc4 ,papa91 ,! ,j\rnal1 ,feb4 #i1 #aijg1 p4 #ebb4 ,,papayans ,,bell1 #aea1 #bhb ,,pap9e1 #ccj ,p>a ,coto & ,p>acoto91 ,reports ,c\ncil ,ph>m4 ,*em41 #aiac1 p4 #ci4 ,,p>aff91 ,,liquid1 ,,p>aff9 ,,oil1 #afa ,,p>ke1 ,,davis ,,co41 #fb1 #acc1 #bca1 #bfg1 #caa1 #cdd1 #cif1 #daj1 #dgd1 #dgf ,,p>ol9e1 #afa ,,pasadyne1 #aef1 #ccb ,,pas-,,av5a ,,& ,,pas-,,av5a ,,co41 #ccc ,,passiflora1 #aef ,,pat*1 ,e4 ,l41 ,,manufactur+ ,,co41 #dgf ,pautaub]ge's ,solution 7,geo4 ,j4 ,wallau71 ,! ,j\rnal1 ,m>* #g1 #aiaj1 p4 #aefj4 ,,pax ,,*emical ,,co1 #cdd ,,peacock ,,*emical ,,co4 ,,& ,,peacock',s ,,bromides1 #bh ,,pe>son ,,co41 #djh ,,p$iatrics1 ,,adv]tis+ ,,91 #aca1 #bif1 #cdb ,,peps9 ,,& ,,pancreat9 ,,mixtures1 #aeg1 #bbi ,peps9 & peps9 & pancreat9 prep>ations1 v>i\s 7,columbus ,ph>macal ,co41 ,eli ,lilly ,co41 ,h4 ,k4 ,mul=d ,co41 ,p>ke1 ,davis ,co41 ,ar?ur ,pet]s ,co41 ,%>p ,dohme1 ,smi?1 ,kl9e ,fr5* ,co41 ,f4 ,/e>ns ,co4 & ,william ,r4 ,w>n] ,co471 ,! ,j\rnal1 ,feb4 #i1 #aijg1 p4 #ecc4 ,pept5zyme1 ,elixir & ,p[d] 7,re$ ,c>nrick ,co471 ,! ,j\rnal1 ,feb4 #i1 #aijg1 p4 #ecc2 ,oct4 #e1 #aijg1 p4 #aaih2 ,reports ,c\ncil ,ph>m4 ,*em41 #aije-h1 p4 #gi4 ,,pepto-,,mangan 7,,gude71 #aei ,peptone1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiac1 p4 #da4 ,,peptones1 ,,liquid1 ,,& ,,peptonic ,,elixir1 #acc ,p]fection ,liquid ,food 7,p]fection ,liquid ,food ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiac41 p4 #dd4 ,,p]tuss91 #ccd ,,petralol1 ,,petro1 ,,names ,,= ,,liquid ,,petrolatum1 #afa ,,petrolatum1 ,,liquid1 ,,cl9ical ,,exp]i5ces ,,)1 #afg ,,petrolatum ,,liquidum1 ,,grave1 ,,& ,,leve1 ,,description ,,(1 #aff ,,petrolax1 ,,petrolia1 ,,petronol1 ,,petrosio1 ,,names ,,= ,,liquid ,,petrolatum1 #afa ,,petroleum ,,emulsion1 ,,angi]',s1 #afi ,,ph>maceutical ,,manufactur]s ,,& ,,! ,,great ,,am]ican ,,fraud1 #dgd ,,phecolates1 ,,phecolax1 ,,phecotones ,,& ,,phecozymes1 #agd ,,ph5acet9 ,,& ,,acetph5etid91 ,,_! ,,relative ,,purity1 #dad ,,ph5ale91 #cdd ,,ph5alg91 #aj1 #cce ,,ph5o-,,bromate ,,& ,,ph5o-,,bromate ,,co41 #cdc ,,ph5ol ,,sodique1 #age ,,ph5olax ,,waf]s1 #cdd ,,ph5olph?ale91 #cdc ,,ph5olph?ale9 ,,laxative1 #cdd ,,phillips1 ,i4 ,g41 #ah ,,phosphatomet]1 ,,d[d',s1 #dgf ,,phosphorus1 ,,amorph\s1 #dgh ,,phosphorus ,,amorph\s1 ,,pill1 ,s4 ,d41 #dhb ,,phosphorus ,,tonic1 ,,comp41 #dgf ,,phospho-,,vanadiol1 #bji ,,phylacog5s1 #cdf ,,phyt91 #agh ,,pi]ce',s ,,favorite ,,prescription1 #daj ,,pi]son1 ,,roma9e1 #dbh ,,p9k]ton1 ,e4 ,d41 #di ,,p9us ,,canad5sis1 ,,k5n$y',s1 #dg ,pip]az9e ,wat] 7,lehn ,f9k71 ,! ,j\rnal1 ,feb4 #bi1 #aijh1 p4 #gjd4 ,,piso',s ,,consumption ,,cure1 #bdb ,,pitman-,,my]s ,,co41 #bfg1 #cdd ,,pix ,,cresol ,,& ,,pix ,,cresol ,,*emical ,,co41 #bdg ,plasmon 7,plasmon ,milk ,products ,co471 ,reports ,*em4 ,lab41 #aiad1 p4 #hh4 ,,plat9um ,,co4 ,,( ,,am]ica1 #cab ,,plessn]1 ,,paul1 ,,co41 #aih ,pluto ,spr+ ,wat]1 ,conc5trat$ 7,fr5* ,lick ,spr+s ,hotel ,co471 ,! ,j\rnal1 ,m>* #bi1 #aiac1 p4 #ajac4 ,,poehl',s ,,sp]m91 #cie ,ponca ,comp\nd 7,melli] ,drug ,co471 ,! ,j\rnal1 ,july #ag1 #aiae1 p4 #bfi2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #fj4 ,poslam 7,em]g5cy ,laboratories71 ,! ,j\rnal1 ,may #bb1 #aiji1 p4 #afgh2 ,reports ,*em41 ,lab41 #aiji1 p4 #be4 ,potassium ,iodo-,resorc9 ,sulphonate1 ,! ,j\rnal1 ,feb4 #aa1 #aiaa1 p4 #dda2 ,reports ,*em4 ,lab41 #aiaa1 p4 #ba4 ,,p[]s-,,weightman-,,ros5g>t5 ,,co41 #beb1 #dae ,,practical ,,druggi/1 #dbh ,,practition]1 ,,adv]tis+ ,,91 #bgi ,,probil91 #cdd ,,proctologi/1 ,,adv]tis+ ,,91 #bif ,,proto ,,puffs1 ,,heal? ,,food ,,nos4 #a ,,& #b1 #dej ,,protonucle91 #cdh ,protonucle9 & ,protonucle9 ,beta 7,re$ ,c>nrick71 ,! ,j\rnal1 ,jan4 #a1 #aiaf1 p4 #dh2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #ij4 ,,protonucle9 ,,special1 #cdi ,,protose1 ,,kellogg',s1 #ddi ,,protosoy ,,diabetic ,,fl\r ,,& ,,waf]s1 #dej ,,prunoids1 #agh1 #cdd ,,psora1 #bdi ,pulsatilla1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #dd4 ,,purdue ,,fr$]ick ,,co1 #ajj ,,purg51 #cdi ,,pyo-,,atox91 #cej ,,pyramidon ,,9 ,,pat5t ,,m$ic9es1 #cbg ,que5 ( ! ,mead[1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #de4 ,qu9a ,la,roche 7,e4 ,f\g]a ,co471 ,! ,j\rnal1 ,m>* #ba1 #aijh1 p4 #igh4 ,qu99 ,ars5ate1 ,! ,j\rnal1 ,july #af1 #aiaj1 p4 #bce2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiaj1 p4 #gc4 ,qu99e ,glyc]ophosphate1 ,reports ,*em4 ,lab41 #aiab1 p4 #ajg4 ,,radam',s ,,microbe ,,kill]1 #dac ,radelium & ! ,radelium ,g5]ator 7,radio-,active ,wat] ,company71 ,reports ,ph>m4 ,*em41 #aiae1 p4 #abh4 ,,rademann',s ,,diabetic ,,prep>ations1 #ddi1 #dej ,radium ,solution = ,intrav5\s ,use1 ,/&>d 7,radium ,*emical ,co471 ,! ,j\rnal1 ,june #bf1 #aiae1 p4 #baef2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #adg4 ,rattlesnake-,v5om1 ,! ,j\rnal1 ,m>* #ae1 #aiac1 p4 #hej2 ,m>* #bi1 #aiac1 p4 #ajja2 ,june #g1 #aiac1 p4 #ahaa4 ,,rectoids1 #bdi ,,reimann1 ,,ar?ur ,e41 #dgg ,,r5go1 #cdh ,,r5ne',s ,,pa9 ,,kill+ ,,oil1 #bje ,,r5ova ,,di/ribut+ ,,co41 #dcd ,,res9ol1 #ceb ,,resor-,,bisnol1 #cec ,respirazone 7,tild5 ,company71 ,! ,j\rnal1 ,june #ad1 #aiac1 p4 #ahii4 ,,rex ,,br& ,,beef ,,extract1 #dga1 #dgb ,rheumalg9e 7,eli ,lilly ,co471 ,! ,j\rnal1 ,june #bf1 #aiae1 p4 #baef2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #adh4 ,rheumatic ,bact]9 7,mix$7 ,no4 #dg1 ,swan's 7,swan-,my]s ,co471 ,! ,j\rnal1 ,nov4 #f1 #aiae1 p4 #affb2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #afj4 ,,ri*>ds1 ,,john ,,morgan1 ,,& ,,sons1 #aba ,,ri*>dson ,,co41 #dgf ,,ri*>dson',s ,,life-,,pres]v+ ,,bitt]s1 #dc ,ric9ol-,grape ,tape-,worm ,rem$y & ,baby ,ta5iafuge-,grape 7,grape ,capsule ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #agd4 ,,rigaud ,,*apoteaut1 #ei ,,rio ,,*emical ,,company1 #dc1 #di ,,rob9ol1 #cec1 #ced ,,rock ,,oil1 #afa ,,roem]1 ,a4 ,,von1 #bjg ,,royal ,,neighbor1 ,,clean ,,adv]tis+ ,,91 #dah ,,ruf1 ,,frank ,a41 #bgf ,,rusks1 ,,call>d',s ,,casoid1 #dej ,,russian ,,m9]al ,,oil1 ,,russian ,,p>aff9 ,,oil1 #afa ,,/4 ,,paul ,,m$ical ,,j\rnal1 ,,adv]tis+ ,,91 #ce ,,salacet9 7,,bell71 #aj1 #aeb1 #cef ,,sal-,,codeia 7,,bell71 #aeb1 #ceg ,,sal ,,hepatica1 #hg1 #agi ,sale/hyl & ,sal-,hyl 7,new ,york ,sale/hyl ,corporation71 ,! ,j\rnal1 ,feb4 #bj1 #aiae1 p4 #fhd2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #acd4 ,,saliod9 ,,& ,,saliod9 ,,*emical ,,co41 #bdi ,salit 7,heyd5 ,*emical ,works71 ,! ,j\rnal1 ,june #e1 #aiji1 p4 #aheb2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiji1 p4 #ajf4 ,,sanatog51 #ceh1 #cgh1 #che ,,sanatog5 ,,& ,,m$ical ,,j\rnals1 #dca ,sangu9>9e ,nitrate1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiaa1 p4 #ei4 ,,sanmetto1 #ahb ,,sanol ,,anti-,,diabetes ,,& ,,sanol ,,manufactur+ ,,co41 ,,ltd4 1 #bii ,,satyria1 #bjb ,,saxol1 ,,liquid ,,saxol9e1 #afa ,,s*]+ ,,glatz1 #bjg1 #bbg1 #cdd ,scopolam9-,morph9 ,mixtures1 ,! ,j\rnal1 ,feb4 #e1 #aiaj1 p4 #ddf2 ,feb4 #ab1 #aiaj1 p4 #eaf2 ,june #g1 #aiac1 p4 #ahad2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiaj1 p4 #aa4 ,,scr(onol1 #dc ,scullcap ,comp\nd1 ,fluidextract 7,p>ke1 ,davis ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #dc4 ,,seabury ,,johnson1 #cjh1 #dgf ,,secretog5 ,,elixir ,,& ,,tablets1 #ahe ,secretog5 & ,elixir ,secretog5 7,g4 ,w4 ,c>nrick ,co471 ,! ,j\rnal1 ,jan4 #ae1 #aiaf1 p4 #agh2 ,reports ,c\ncil ,ph>m4 ,*em41 p4 #ii4 ,s$obrol 8,ro*e0 7,h(fman-,la,roche ,*emical ,works71 ,! ,j\rnal1 ,jan4 #b1 #aiae1 p4 #ga2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiad4 ,sel5ium comp\nds 79 8,*emo!rapy & ,tumors071 ,! ,j\rnal1 ,april #ag1 #aiae1 p4 #abhc2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #bh4 ,semprol9 7,w4 ,br[n+ ,co471 ,! ,j\rnal1 ,july #aj1 #aiae1 p4 #age4 ,,s5eka ,,oil1 #afa ,s5g 7,sultan ,drug ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #abi4 ,,septicide1 #dac ,s]um ,vacc9e1 ,brus*ett9i 7,r4 ,g4 ,b]l+i]i71 ,! ,j\rnal1 ,nov4 #ba1 #aiad1 p4 #ahgj2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiad1 p4 #abg4 ,sev5-,b>k1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #de4 ,,sevetol1 #cec1 #cee ,,%ac1 #dgf ,,%>p ,,dohme1 #acc1 #bca1 #dgf ,,s9k9a1 #adi1 #aej1 #aea1 #ahh ,sirol9 7,sirol9 ,co471 ,! ,j\rnal1 ,june #ba1 #aiac1 p4 #aigd4 ,,smi? ,,bile ,,beans ,,co4 ,,& ,,smi?',s ,,bile ,,beans1 #dc ,,smi?1 ,,*>les ,b41 #aee ,,smi?1 ,,kl9e ,,& ,,fr5* ,,co41 #daj ,,smi?1 ,,m>t9 ,h41 ,,co41 #hb1 #hh ,,society ,,( ,,*emical ,,indu/ry1 #agh ,,soja ,,bean ,,meals1 #dej ,,somnalges9e1 #ccc ,,somnos1 #aic ,s\rwood & ,s\rwood ,elixirs 7,eli ,lilly ,co4 & ,p>ke1 ,davis ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #de4 ,,s\? ,,texas ,,m$ical ,,record1 ,,cr$itable ,,adv]tis+ ,,91 #ddj ,,s\!rn ,,practition]1 ,,adv]tis+ ,,91 #ca1 #ce1 #bgi ,,s\?we/ ,,j\rnal ,,( ,,m$ic9e ,,& ,,surg]y1 ,,adv]tis+ ,,91 #cjj ,,soy ,,fl\rs1 #dej ,,sp5c]',s ,,almond ,,pa/e1 #dej ,,sp]m9um ,,poehl1 #cie ,squaw ,root1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #dj4 ,squaw-v9e & squaw-v9e prep>ations 7,eli ,lilly ,co41 ,p>ke1 ,davis ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #de4 ,,squibb1 ,e4 ,r41 ,,sons1 #beb1 #dae ,/&>d ,radium ,solution = ,intrav5\s ,use 7,radium ,*emical ,co471 ,! ,j\rnal1 ,june #bf1 #aiae1 p4 #baef2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #adg4 ,,/e>ns1 ,,fr$]ick1 ,,co41 #bfg1 #daj1 #dgf ,/e>ns' ,w9e 7,fr$]ick ,/e>ns ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #agg4 ,,/]l+ ,,rem$y ,,co41 #dge ,,/ev5son ,,je/] ,,co41 #acc ,/ill+ia prep>ations1 v>i\s 7,hance ,bros4 ,:ite1 ,h4 ,k4 ,mul=d ,co41 ,p>ke1 ,davis ,co41 ,ray ,*emical ,co4 & ,smi?1 ,kl9e ,fr5* ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 pp4 #db1 #dg4 ,/one ,root1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #df4 ,,/rong1 ,,cobb ,,co41 #fa1 #ha ,/ry*n9 ,ars5ate1 ,! ,j\rnal1 ,sept4 #bd1 #aiaj1 p4 #aabh2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiaj1 p4 #gd4 ,,succus ,,alt]ans1 #aie ,,succus ,,c9]>ia ,,m>itima 7,,walk]71 #ej ,sug> ,cane1 ,*9ese1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #ci4 ,,sulpho-,,ly?91 #aif ,,sultan ,,drug ,,company1 #cg1 #agh1 #cdd ,,susp5sory1 ,o-,p-,c1 #dcf ,,swaim',s ,,panacea1 #bje ,,swa9',s ,,all-,,heal+ ,,o9tm5t ,,& ,,swa9',s ,,laboratory1 #dc ,swan's ,rheumatic ,bact]9 7,mix$7 ,no4 #dg 7,swan-,my]s ,co471 ,! ,j\rnal1 ,nov4 #f1 #aiae1 p4 #affb2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #afj4 ,,swift ,,co41 #dga ,,syn]gia1 #bca ,,syrup ,,( ,,cocillana ,,comp\nd1 #cif ,,syrup ,,( ,,hydriodic ,,acid1 ,,g>dn]',s1 #ig ,,syrup ,,( ,,lactuc>ium1 ,,aub]gi]',s1 #cii ,syrup ( ,malt1 ,williams' 7,am]ican ,malt ,extract ,co471 ,! ,j\rnal1 ,sept4 #d1 #aiae1 p4 #hie4 ,,sz5deffy1 ,,dr4 ,r4 ,,de1 #gd ,tabloge/9 7,f4 ,h4 ,/rong ,co471 ,! ,j\rnal1 ,dec4 #aa1 #aiae1 p4 #bajh4 ,,taka-,,dia/ase ,,& ,,liquid ,,taka-,,dia/ase1 #fb ,tannyl 7,*>les ,gosl>71 ,reports ,*em4 ,lab41 #aiab1 p4 #ajh4 ,,t>t>li?9e ,,& ,,t>t>li?9e ,,co41 #dja ,,taurocol ,,tablets ,,& ,,comp\nd ,,tablets1 #aih ,,t5nant1 ,,george ,c41 #aee ,,t]ralbolia1 ,,t]ral9e1 ,,names ,,= ,,liquid ,,petrolatum1 #afa ,,texas ,,m$ical ,,j\rnal1 ,,adv]tis+ ,,91 #ca1 #ce1 #di ,,texas ,,m$ical ,,news1 ,,adv]tis+ ,,91 #ca1 #ce ,,?alos51 #cdd ,,!obrom9 ,,sodium ,,salicylate ,,v]sus ,,diuret91 #bea ,,!rapeutic ,,gazette1 ,,adv]tis+ ,,91 #ca1 #ce ,,!rapeutic ,,record1 ,,adv]tis+ ,,91 #bgi1 #cjj ,,?ialion1 #bje ,?iocol & ,syrup ,?iocol-,ro*e 7,h(fmann-,la ,ro*e ,*emical ,works71 ,! ,j\rnal1 ,june #ba1 #aiac1 p4 #aigd2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiac1 p4 #af4 ,?i(orm 7,otto ,hann ,bro471 ,reports ,*em41 ,lab41 #aiji1 p4 #gi4 ,,?ompson',s ,,malt$ ,,food ,,co41 #cai ,,?oxos1 #djb ,,?ree ,,*lorides 7,,h5ry71 #aih1 #bja ,,tild5 ,,co41 #bce1 #cbi ,,tol$o ,,m$ical ,,& ,,surgical ,,report]1 ,,adv]tis+ ,,91 #bif ,tonga & v>i\s tonga prep>ations 7,hance ,bros4 ,:ite1 ,eli ,lilly ,co41 ,william ,s4 ,m]rell ,*emical ,co41 ,nelson1 ,bak] ,co41 ,p>ke1 ,davis ,co41 ,ray ,*emical ,co41 ,%>p ,dohme1 ,f4 ,/e>ns ,co41 ,william ,r4 ,w>n] ,co4 & ,h4 ,k4 ,wampole ,co471 ,! ,j\rnal1 ,may #aj1 #aiac1 p4 #adgh2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #df4 ,tongal9e & ,tongal9e ,tablets 7,melli] ,drug ,co471 ,! ,j\rnal1 ,july #ag1 #aiae1 p4 #bfi2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #eh4 ,,tonic ,,beef1 ,s4 ,d41 #acc ,tox9ol 7,hughes ,*emical ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #ci4 ,,tri-,,iodides1 #aih1 #aii ,trifolium prep>ations1 v>i\s 7,hance ,bros4 ,:ite1 ,eli ,lilly ,co41 ,william ,s4 ,m]rell ,*emical ,co41 ,h4 ,k4 ,mul=d ,co41 ,p>ke1 ,davis ,co41 ,ray ,*emical ,co4 & ,f4 ,/e>ns ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 pp4 #ci1 #dj4 ,tril5e ,tablets1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #ci4 ,trophon9e 7,re$ ,c>nrick ,co471 ,! ,j\rnal1 ,oct4 #e1 #aijg1 p4 #aaih2 ,reports ,c\ncil ,ph>m4 ,*em41 #aije-h1 p4 #gi4 ,,truax1 ,,gre5e ,,co41 #bca ,,trypsog51 #djc ,tub]cle ,vacc9e1 ,non-,virul5t1 ,%]man's 7,g4 ,h4 ,%]man71 ,! ,j\rnal1 ,nov4 #ba1 #aiad1 p4 #ahgj2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiad1 p4 #abh4 ,tub]cul9 ,te/ ,plate1 ,kell]'s 7,a4 ,h4 ,kell]71 ,! ,j\rnal1 ,dec4 #ai1 #aiad1 p4 #bbej4 ,tub]culoids 7,columbus ,ph>macal ,company71 ,! ,j\rnal1 ,feb4 #bb1 #aijh1 p4 #gjd4 ,tubo-,arg 7,tubo ,ph>macal ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #age4 ,turkey ,corn1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #dg4 ,,turn]1 ,f4 ,m41 ,,& ,,! ,,dr4 ,,turn] ,,co41 #baa ,,tyree1 ,j4 ,s41 #ba1 #dje ,,tyree',s ,,antiseptic ,,p[d]1 #ba1 #djd ,,tyree',s ,,elixir ,,bu*u ,,& ,,hyoscyamus ,,comp41 #djg ,tyree's ,elixir ( ,bu*u & ,hyoscyamus ,comp\nd 7,j4 ,s4 ,tyree71 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #afg4 ,ulax ,salt 7,f4 ,h4 ,/rong ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #age4 ,,ungu5t9e1 #bed ,,ungu5tum ,,sel5io ,,vanadic 7,v4 ,,roem]71 #bjg ,,unicorn ,,root1 #bjh ,,unit$ ,,/ates ,,heal? ,,reports1 #dcc ,,upjohn ,,co41 #cdd ,uranobl5 7,a4 ,grimme71 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #agf4 ,urasol 7,organic ,*emical ,mfg4 ,co471 ,! ,j\rnal1 ,sept4 #e1 #aijh1 p4 #hah2 ,may #h1 #aiji1 p4 #aeaa2 ,reports ,c\ncil ,ph>m4 ,*em41 #aije-h1 p4 #aff2 #aiji1 p4 #fd4 ,,uric ,,acid ,,mon?ly1 #bjg ,,uric$91 #bef ,uricsol 7,uricsol ,*emical ,co471 ,! ,j\rnal1 ,aug4 #ad1 #aiae1 p4 #fch2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #adi4 ,,urisept91 #bef ,urodonal 7,geo4 ,j4 ,wallau1 ,inc471 ,! ,j\rnal1 ,aug4 #ad1 #aiae1 p4 #fci2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #aec4 ,uron 7,uron ,*emical ,company71 ,! ,j\rnal1 ,nov4 #c1 #aijf1 p4 #aejj2 ,reports ,c\ncil ,ph>m4 ,*em41 #aije-h1 p4 #bf4 ,,usol9e1 #afa ,,ut]9e ,,s$ative ,,elixir1 #daj ,ut]9e ,s$ative1 ,elixir 7,eli ,lilly ,co471 ,! ,j\rnal1 ,aug4 #ca1 #aiab1 p4 #gce2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #dd4 ,ut]9e tonics1 v>i\s 7,abbott ,alkaloidal ,co41 ,gir>d ,*emical ,co41 ,maltbie ,*emical ,co41 ,h4 ,k4 ,mul=d ,co41 ,nelson1 ,bak] ,co41 ,p>ke1 ,davis ,co4 & ,f4 ,/e>ns ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 pp4 #da1 #df4 ,,ut]9e ,,waf]s1 ,,micajah',s ,,m$icat$1 #bdj ,vacc9e1 ,curative1 ,brus*ett9i 7,a4 ,brus*ett9i71 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #agf4 ,vacc9e1 ,fri$mann's 7,/&>d ,di/ribut+ ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiad1 p4 #acf4 ,,vacc9e1 ,,mix$1 #cdf ,vacc9e1 ,non-,virul5t ,tub]cle ,bacillus 7,g4 ,h4 ,%]man71 ,! ,j\rnal1 ,sept4 #bj1 #aiac1 p4 #igi4 ,,val5t9e1 ,m4 ,j41 #abc ,,val5t9e',s ,,meat ,,juice1 #abc1 #abe1 #abi ,,val5t9e',s ,,meat ,,juice ,,co41 #dgb ,vanadic ,acid1 ,! ,j\rnal1 ,may #i1 #aijh1 p4 #aedh2 ,july #bd1 #aiji1 p4 #cji4 ,,vanadiol1 ,,vanadioseptol ,,& ,,vanadium ,,solution ,,= ,,intrav5\s ,,& ,,hypod]mic ,,use1 #bji ,vanadium1 ,! ,j\rnal1 ,june #c1 #aiaa1 p4 #afdh4 ,,vanadium ,,*emical ,,co41 #bja1 #baa ,,vanad(orme1 #baj ,,vapo-,,cresol5e1 #djh ,,vasel9e1 ,,liquid1 #afa ,,vasog51 #djh ,,vass ,,*emical ,,co41 #bje ,,v5>s51 #bab ,,v5od9e1 #bad ,,v]acolate1 #baf1 #cdd ,,v]mont ,,m$ical ,,mon?ly1 ,,adv]tis+ ,,91 #ce ,v](orm ,g]micide 7,v](orm ,hygi5ic ,co471 ,! ,j\rnal1 ,nov4 #bb1 #aiac1 p4 #aibj4 ,,vial1 ,,new ,,york ,,laboratories ,,(1 #ei ,viburn-,ov>o 7,ray ,*emical ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #df4 ,,viburnum ,,comp\nd1 ,,elixir ,,(1 #daj ,,viburnum ,,comp\nd1 ,,hayd5',s1 #bah1 #dji ,viburnum prep>ations1 v>i\s 7,fras] ,tablet ,co41 ,p>ke1 ,davis ,co4 & ,smi?1 ,kl9e ,fr5* ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #df4 ,,viburnumal1 #daj ,,vibut]o1 #daj ,,vigoral1 #dgb ,,v9 ,,m>iani1 #bba ,,v9ol1 #ddc ,v9um ,ext4 ,morrhuae1 ,/e>ns 7,fr$]ick ,/e>ns ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #agg4 ,,virg9ia ,,m$ical ,,semi-,,mon?ly1 ,,adv]tis+ ,,91 #aca ,,virol ,,& ,,virol1 ,,ltd41 #bbe ,,vitaopa?y1 #dge ,,walk] ,,ph>macal ,,co41 #ej1 #bch1 #bdj ,,walk]1 ,,w ,e41 #ah ,,wallau1 ,,george ,j41 ,,inc41 #ajf ,,wampole1 ,,h5ry ,k41 ,,co41 ,,inc41 #bf1 #eb ,,wampole',s ,,p]fect$ ,,& ,,ta/eless ,,prep>ation ,,( ,,an ,,extract ,,( ,,cod ,,liv]1 #eb1 #ddc ,,w>n]1 ,w4 ,r41 ,,co41 #aja ,wat] ,eryngo1 ,reports ,c\ncil ,ph>m4 ,*em41 #aiab1 p4 #dg4 ,,wat]bury ,,*emical ,,co41 #ed1 #eg1 #dfc ,,wat]bury',s ,,comp\nd1 #ed1 #eg1 #bia1 #ddc ,,we/]n ,,canada ,,m$ical ,,j\rnal1 ,,adv]tis+ ,,91 #cjj ,,:eel] ,,*emical ,,works1 #bde ,,:eel]',s ,,n]ve ,,vitaliz]1 #daa ,:it]uss 7,lubric ,oil ,co471 ,! ,j\rnal1 ,july #aj1 #aiae1 p4 #age4 ,:ite ,sulphur ,salts 7,:ite ,sulphur ,spr+s1 ,inc471 ,! ,j\rnal1 ,nov4 #ba1 #aiad1 p4 #ahgj2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiad4 ,,:it+',s ,,sug>-,,free ,,milk1 #ddi ,,:itney1 ,f4 ,,waldo1 #agd ,,wild ,,indigo1 #bji ,,wild ,,yam1 #bjh ,williams' ,syrup ( ,malt 7,am]ican ,malt ,extract ,co471 ,! ,j\rnal1 ,sept4 #d1 #aiae1 p4 #hie2 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #aee4 ,,w9e1 ,,*apoteaut',s1 #fj ,w9e ( ,cod ,liv] ,ext4 ) ,peptonate ( ,iron1 ,/e>ns' 7,fr$]ick ,/e>ns ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiae1 p4 #agg4 ,,wiscons9 ,,m$ical ,,record]1 ,,adv]tis+ ,,91 #ca1 #ce ,,woman',s ,,m$ical ,,j\rnal1 ,,adv]tis+ ,,91 #ca1 #di ,,wye?',s ,,beef ,,juice1 #abc1 #abe1 #abf ,,wye?1 ,,john1 ,,bro!r1 #abc1 #acc1 #bei1 #bib1 #ced1 #djb1 #dgb ,xanol 7,wm4 ,s4 ,m]rell ,*emical ,co471 ,reports ,c\ncil ,ph>m4 ,*em41 #aiaa1 p4 #fd4 ,,yam1 ,,wild1 #bjh ,yogurt 7,yogurt ,co471 ,! ,j\rnal1 ,jan4 #cj1 #aiji1 pp4 #cgb1 #cig4 ,,zemacol1 #bei ,,zymotoid1 #dab ,,zyme-,,oid1 #bfa ,,zymole ,,trokeys1 #dgf ,,zumota1 #dcf ,spell+ inconsi/5cies3 qu99_/qu99e soluble_/solubile_/soluable glucosid_/glucoside p]oxid_/p]oxide oxid_/oxide ,hydra/9_/,hydra/9e small-pox_/smallpox proto*lorid_/proto*loride n>cot9_/n>cot9e anilpyr9e_/anilipyr9e v5d]_/v5dor *emic_/*emical /ry*n9_//ry*n9e pseudo-sci5tific_/pseudosci5tific semi-secret_/semisecret beta-naph?ol_/betanaph?ol to-day_/today acetyl-salicylic_/acetysalicylic indorse_/endorse indorsem5t_/endorsem5t gm4_/,gm4 ,spell+ corrections3 fol[+ -- foll[+ waf] -- wat] ,am$em9 -- ,an$em9 ,prepration -- ,prep>ation he -- ! decription -- description adm9i/ation -- adm9i/ration ov5 -- ev5 te/ -- te/s con/itut5t -- con/itu5t iut5sive -- int5sive accur>y -- accuracy ,helionas -- ,helonias ,phamacopeia -- ,ph>macopeia canc]ns -- conc]ns repiration -- respiration commitee -- committee amp\les -- ampules fradul5t -- fraudul5t ,?p -- ,! ,dia/ate -- ,dia/ase dim9%$ -- dim9i%$ acetph55tid9 -- acetph5etid9 #a1afi -- #a1ffi 79 table7 effci5cy -- effici5cy t -- ?an ?\ght -- b\ght ,fur!more -- ,fur!rmore b>eley -- b>ley acetph5tid9 - acetph5etid9 prramidon -- pyramidon valuless -- valueless conta+ -- conta9+ ,am]ican -- ,am]ica article -- articles ness>y -- necess>y out -- our /rotium -- /rontium s]cret9 -- secret9 radicles -- radicals ,specim5t -- ,specim5 ata9$ -- atta9$ wo -- woe w\nd]s -- wond]s lives -- liv]s matire -- matire ,geseundhitslehr] -- ,geseundheitslehr] readibly -- readily alkoloids -- alkaloids is -- x me?ol -- m5?ol amyolytic -- amylolytic