,,transcrib] ,,notes3 ,words 9 italics are indicat$ ) an und]score 77 at ! beg9+ & end4 ,words 9 bold are indicat$ ) an equal sign 77 at ! beg9+ & end4 ,subscripts conta9$ 9 *emical notations are indicat$ z 4 ,! table on page #cb has be5 modifi$ to fit by ! use ( keys to replace "s ( ! in=mation4 ,u4 ,s4 ,,dep>tm5t ,,( ,,agriculture4 ,,bureau ,,( ,,plant ,,indu/ry--,,bullet9 ,,no4 #abi4 ,b4 ,t4 ,,gall[ay1 ,*ief ( ,bureau4 ,,b>ium1 ,a ,,cause ,,( ,,! ,,loco-,,we$ ,,disease4 ,,by ,,alb]t ,c4 ,,craw=d1 ,,ph>macologi/1 ,,poison\s-,,plant ,,inve/igations4 ,,issu$ ,,augu/ #bb1 #aijh4 ,illu/ration ,,wa%+ton3 ,,gov]nm5t ,,pr9t+ ,,(fice4 #aijh4 ,,bureau ,,( ,,plant ,,indu/ry4 ,physiologi/ & ,pa?ologi/1 & ,*ief ( ,bureau1 ,bev]ly ,t4 ,gall[ay4 ,physiologi/ & ,pa?ologi/1 & ,assi/ant ,*ief ( ,bureau1 ,alb]t ,f4 ,woods4 ,laboratory ( ,plant ,pa?ology1 ,erw9 ,f4 ,smi?1 ,pa?ologi/ 9 ,*>ge4 ,inve/igations ( ,diseases ( ,fruits1 ,m]ton ,b4 ,waite1 ,pa?ologi/ 9 ,*>ge4 ,laboratory ( ,=e/ ,pa?ology1 ,hav5 ,metcalf1 ,pa?ologi/ 9 ,*>ge4 ,cotton & ,truck ,diseases & ,plant ,disease ,survey1 ,william ,a4 ,orton1 ,pa?ologi/ 9 ,*>ge4 ,plant ,life ,hi/ory ,inve/igations1 ,walt] ,t4 ,sw+le1 ,physiologi/ 9 ,*>ge4 ,cotton ,bre$+ ,inve/igations1 ,ar*ibald ,d4 ,%amel & ,daniel ,n4 ,%oemak]1 ,physiologi/s 9 ,*>ge4 ,tobacco ,inve/igations1 ,ar*ibald ,d4 ,%amel1 ,wightman ,w4 ,g>n]1 & ,erne/ ,h4 ,ma!wson1 9 ,*>ge4 ,corn ,inve/igations1 ,*>les ,p4 ,h>tley1 ,physiologi/ 9 ,*>ge4 ,alkali & ,dr\ght ,resi/ant ,plant ,bre$+ ,inve/igations1 ,?omas ,h4 ,ke>ney1 ,physiologi/ 9 ,*>ge4 ,soil ,bact]iology & ,wat] ,purification ,inve/igations1 ,k>l ,f4 ,kell]man1 ,physiologi/ 9 ,*>ge4 ,bionomic ,inve/igations ( ,tropical & ,subtropical ,plants1 ,orator ,f4 ,cook1 ,bionomi/ 9 ,*>ge4 ,drug & ,poison\s ,plant ,inve/igations & ,tea ,culture ,inve/igations1 ,rodney ,h4 ,true1 ,physiologi/ 9 ,*>ge4 ,physical ,laboratory1 ,lyman ,j4 ,briggs1 ,physici/ 9 ,*>ge4 ,crop ,te*nology & ,fib] ,plant ,inve/igations1 ,na?an ,a4 ,cobb1 ,crop ,te*nologi/ 9 ,*>ge4 ,taxonomic & ,range ,inve/igations1 ,fr$]ick ,v4 ,coville1 ,botani/ 9 ,*>ge4 ,f>m ,managem5t ,inve/igations1 ,william ,j4 ,spillman1 ,agriculturi/ 9 ,*>ge4 ,gra9 ,inve/igations1 ,m>k ,alfr$ ,c>leton1 ,c]eali/ 9 ,*>ge4 ,arl+ton ,exp]im5tal ,f>m1 ,lee ,c4 ,corbett1 ,horticulturi/ 9 ,*>ge4 ,vegetable ,te/+ ,g>d5s1 ,william ,w4 ,tracy1 sr41 ,sup]9t5d5t4 ,sug>-,beet ,inve/igations1 ,*>les ,o4 ,t[ns5d1 ,pa?ologi/ 9 ,*>ge4 ,we/]n ,agricultural ,ext5sion ,inve/igations1 ,c>l ,s4 ,sc(ield1 ,agriculturi/ 9 ,*>ge4 ,dry-,l& ,agriculture ,inve/igations1 ,e4 ,*ann+ ,*ilcott1 ,agriculturi/ 9 ,*>ge4 ,pomological ,collections1 ,gu/avus ,b4 ,brackett1 ,pomologi/ 9 ,*>ge4 ,field ,inve/igations 9 ,pomology1 ,william ,a4 ,taylor & ,g4 ,h>old ,p[ell1 ,pomologi/s 9 ,*>ge4 ,exp]im5tal ,g>d5s & ,gr\nds1 ,edw>d ,n4 ,byrnes1 ,sup]9t5d5t4 ,=eign ,se$ & ,plant ,introduction1 ,david ,fair*ild1 ,agricultural ,explor] 9 ,*>ge4 ,=age ,crop ,inve/igations1 ,*>les ,v4 ,pip]1 ,agro/ologi/ 9 ,*>ge4 ,se$ ,laboratory1 ,edg> ,br[n1 ,botani/ 9 ,*>ge4 ,gra9 ,/&>dization1 ,john ,d4 ,%anahan1 ,crop ,te*nologi/ 9 ,*>ge4 ,subtropical ,laboratory & ,g>d51 ,miami1 ,fla41 ,ern/ ,a4 ,bessey1 ,pa?ologi/ 9 ,*>ge4 ,plant ,introduction ,g>d51 ,*ico1 ,cal41 ,w4 ,w4 ,tracy1 jr41 ,assi/ant ,botani/ 9 ,*>ge4 ,s\? ,texas ,g>d51 ,br[nsville1 ,tex41 ,edw>d ,c4 ,gre51 ,pomologi/ 9 ,*>ge4 ,f>m]s' ,coop]ative ,demon/ration ,"w1 ,seaman ,a4 ,knapp1 ,special ,ag5t 9 ,*>ge4 ,se$ ,di/ribution 7,direct$ by ,*ief ( ,bureau71 ,lisle ,morrison1 ,assi/ant 9 ,g5]al ,*>ge4 ,editor1 ,j4 ,e4 ,rockwell4 ,*ief ,cl]k1 ,james ,e4 ,jones4 ,,poison\s-,,plant ,,inve/igations4 ,,sci5tific ,,/aff4 ,rodney ,h4 ,true1 ,physiologi/ 9 ,*>ge4 ,c4 ,dwight ,m>%1 ,exp]t 9 ,*>ge ( ,field ,inve/igations4 ,alb]t ,c4 ,craw=d1 ,ph>macologi/4 ,ar?ur ,b4 ,clawson1 ,exp]t 9 ,field ,inve/igations4 ,iv> ,tide/rom1 ,assi/ant ,botani/1 9 ,coop]ation ) ,=e/ ,s]vice4 ,,lett] ,,( ,,transmittal4 ,u4 ,s4 ,,dep>tm5t ,,( ,,agriculture1 ,,bureau ,,( ,,plant ,,indu/ry1 ,,(fice ,,( ,,! ,,*ief1 ,wa%+ton1 ,d4 ,c41 ,april #aj1 #aijh4 ,,sir3 ,i h ! honor to transmit h]e) ! manuscript ( a te*nical bullet9 entitl$ ,b>ium1 a ,cause ( ! ,loco-,we$ ,disease1 prep>$ by ,dr4 ,a4 ,c4 ,craw=d1 ,ph>macologi/1 "u ! direction ( ,dr4 ,rodney ,h4 ,true1 ,physiologi/ 9 ,*>ge ( ,poison\s-,plant ,inve/igations1 & to recomm5d t x be publi%$ z ,bullet9 ,no4 #abi ( ! s]ies ( ?is ,bureau4 ,= _m ye>s ! /ockm5 9 _m p>ts ( ! ,we/ h report$ disa/r\s consequ5ces foll[+ ! eat+ ( s-call$ loco we$s *>act]i/ic ( ! regions involv$4 ,:ile _m h d\bt$ any causal relation betwe5 ! plants 9 "q & ! /ock losses1 ! reality ( ! damage has rema9$ & has seem$ to require a ?or\ghgo+ sift+ ( ! evid5ce conc]n+ ! "p play$ by ! plants4 ,accord+ly1 9 ! spr+ ( #aije a /ation = ! exp]im5tal /udy ( ! problem 0 e/abli%$ at ,hugo1 ,colo41 9 *>ge ( ,dr4 ,c4 ,dwight ,m>%1 ,exp]t1 9 coop]ation ) ! ,colorado ,agricultural ,exp]im5t ,/ation4 ,lat] a fur!r fe$+ exp]im5t 0 und]tak5 at ,imp]ial1 ,nebr41 9 coop]ation ) ! ,nebraska ,agricultural ,exp]im5t ,/ation4 ,p>allel ) ! fe$+ "w 9 ! field1 laboratory "w1 design$ to te/ "u laboratory conditions ! poison\s action ( ! plants f giv5 areas1 0 und]tak5 at ,wa%+ton by ,dr4 ,a4 ,c4 ,craw=d1 ,ph>macologi/4 ,a fur!r phase ( 8 "p ( ! "w 0 an attempt to asc]ta9 ! nature ( su* poison\s sub/ance or sub/ances z might occur 9 ! loco plants4 ,9 bo? ( ^! l9es ( "w ,doctor ,craw=d has be5 successful1 & ! te*nical results ( 8 "w are "h collect$4 ,respectfully1 ,b4 ,t4 ,,gall[ay1 ,*ief ( ,bureau4 ,hon4 ,,james ,,wilson1 ,secret>y ( ,agriculture4 ,,introductory ,,/atem5t4 ,a sci5tific und]/&+ ( ! s-call$ loco-we$ disease has be5 dem&$ & s\ght aft] = sev]al decades = mo/ practical purposes1 b1 9 spite ( ! great am\nt ( att5tion :i* ?is problem has receiv$1 no g5]al agreem5t has be5 f\nd among ! results obta9$4 ,! field inve/igations h giv5 su* contradictory evid5ce t until ! ,bureau ( ,plant ,indu/ry ( ! ,dep>tm5t ( ,agriculture turn$ its att5tion to ! matt] ! :ole subject ( ! loco disease 0 reg>d$ by _m z a k9d ( delusion & ! exi/5ce ( a di/9ct entity 0 freely d\bt$4 ,n only did ?is confusion *>act]ize ! field aspect ( ! matt]1 b ! situation view$ f ! /&po9t ( laboratory /udy 0 also mu* obscur$4 ,"s inve/igators claim$ to h sep>at$ poison\s sub/ances ( v>i\s sorts f ! loco we$s1 :ile o!rs ( equal sci5tific /&+ d5i$ ! pres5ce ( any poison\s sub/ance 9 ! plants "u g5]al suspicion--! s-call$ loco we$s4 ,9 view ( ! great s]i\sness ( ! loco situation f ! /&po9t ( ! /ock int]e/s1 an active campaign bo? 9 ! l9e ( fe$+ exp]im5ts 9 ! field & laboratory /udy at ,wa%+ton 0 und]tak5 by ! ,(fice ( ,poison\s-,plant ,inve/igations ( ! ,bureau ( ,plant ,indu/ry4 ,! fe$+ exp]im5ts c>ri$ out at ,hugo1 ,colo41 9 coop]ation ) ! ,colorado ,agricultural ,exp]im5t ,/ation1 be=e ! close ( ! fir/ season develop$ evid5ce t !re 0 9 reality su* a ?+ z a loco disease4 ,! inve/igator 9 *>ge 0 enabl$ to describe ! disease 9 its mo/ important manife/ations & made x possible to sift ! facts f ! l>ge numb] ( contradictory /atem5ts 9 ! lit]ature4 ,! laboratory "w1 und]tak5 & c>ri$ on simultane\sly1 consi/$ ( a ph>macological /udy1 "u laboratory conditions & ) ! usual laboratory subjects1 ( ! action ( plant mat]ial s5t 9 f ! field4 ,! acute phase ( loco-we$ poison+1 z well z a m prolong$ type ( ! disease1 0 /udi$4 ,9 plants f\nd 9 ?is prelim9>y fe$+ to be h>mful1 ! poison\s pr9ciple 0 s\ght1 ) ! v /rik+ results fully describ$ 9 ?is pap]4 ,! demon/ration ( ! pres5ce ( b>ium 9 ! plants 0 foll[$ by b>ium fe$+1 ) ! production ( symptoms :i* agre$ ) ^? produc$ 9 ! laboratory ) loco extracts & 9 ! field exp]im5ts ) ! loco plants z se5 gr[+ on ! range4 ,by comp>+ ^! laboratory results ) ^? produc$ 9 connection ) ! field "w1 x became possible to sift ! :eat f ! *aff 9 ! mass ( contradictory evid5ce detail$ 9 ! lit]ature ( ?is subject4 ,! practical importance ( ! discov]y ( ! true nature ( ! active poison\s pr9ciple ( ! loco we$s is v great4 ,x n only %$s light on ! loco situation & enables "o to expla9 _m hi!rto inexplicable ?+s1 b x also adds mu* to our k ( b>ium 9 its m$ical be>+s4 ,x op5s up mo/ important problems conc]n+ ! soils & ! relation ( ! flora to !m4 ,x %\ld be borne 9 m9d t al?\gh b>ium is %[n to be *iefly responsible = ! poison\s prop]ties ( loco we$s 9 ea/]n ,colorado1 x is entirely possible t 9 o!r regions o!r sub/ances may be equally or ev5 m significant4 ,?is discov]y also seems likely to provide a basis = a rational treatm5t ( loco$ /ock4 ,un=tunately1 ! discov]y ( ! fact t b>ium is ! poison\s con/itu5t ( loco we$s came too late to aid 9 ! se>* = rem$ial measures on ! range dur+ ! p]iod cov]$ by ?is report1 b ^? empirically arriv$ at h receiv$ additional support f ^! laboratory results4 ,?us ! "w 9 field & laboratory1 und]tak5 aft] repeat$ attempts & disc\rag+ failures by o!rs1 has yield$ results to p]si/5t sci5tific rese>* & promises practical aid to ! n[ suff]+ live-/ock int]e/s4 ,! results ( ! laboratory "w are pres5t$ 9 ?is bullet94 ,,rodney ,h4 ,,true1 ,physiologi/ 9 ,*>ge4 ,,cont5ts4 ,page4 ,geographical di/ribution ( ! loco-we$ disease & alli$ conditions #i ,plants associat$ ) ! loco$ condition #aj ,cl9ical symptoms ( loco$ animals z describ$ 9 lit]ature #ab ,conditions simil> to loco-we$ poison+ 9 o!r p>ts ( ! _w #af ,pa?ological conditions 9 loco$ animals z describ$ on ! range #ah ,hi/orical sket* ( loco inve/igations f a ph>macological /&po9t #ai ,notes on v>i\s memb]s ( ! loco-we$ family #ce ,laboratory exp]im5ts--physiological #cf ,exp]im5ts on rabbits #cf ,acute cases #cf ,*ronic cases #ch ,pregnant animals #db ,subcutane\s injections #dc ,summ>y ( fe$+ exp]im5ts on rabbits #dd ,exp]im5ts on %eep #dd ,laboratory exp]im5ts--*emical #df ,effect ( ! aque\s extract ( a%$ loco plants #di ,total a% det]m9ations ( loco plants #ed ,b>ium det]m9ations 9 ! a% ( loco plants #ee ,analysis ( soils #eg ,fe$+ exp]im5ts ) b>ium salts on animals 9 ! laboratory #eg ,b>ium poison+ 9 man #fb ,pa?ological lesions 9 exp]im5tal b>ium poison+ #fe ,toxicity ( v>i\s aque\s extracts ( loco plants #ff ,!oretical antidote = loco-we$ poison+ #ga ,action ( b>ium on dome/ic & f>m animals #gb ,application ( ! results ( ^! inve/igations to ! range #gd ,conclusions #ge ,index #gg ,,b>ium1 ,a ,,cause ,,( ,,! ,,loco-,,we$ ,,disease4 ,,geographical ,,di/ribution ,,( ,,! ,,loco-,,we$ ,,disease ,,& ,,alli$ ,,conditions4 ,9 our ,we/]n ,/ates !re is a m>k$ annual loss ( /ock due to v>i\s causes4 ,"s ( ^! animals die 9 a condition kn[n z loco$1 a t]m d]iv$ f ! ,spani% ^w loco1 mean+ fooli% or crazy4 ,?is disord] ext5ds f ,montana to ,texas & ,mexico1 & f ,kansas & ,nebraska to ,cali=nia4#a ,9 #ahih ! ,unit$ ,/ates ,dep>tm5t ( ,agriculture s5t out1 "u ! imm$iate direction ( ,mr4 ,v4 ,k4 ,*esnut1 a reque/ = in=mation conc]n+ ! ravages ( ! loco disease4 ,x 0 f\nd t 9 ! t5 ,/ates ( ,cali=nia1 ,colorado1 ,kansas1 ,montana1 ,nebraska1 ,new ,mexico1 ,nor? ,dakota1 ,oklahoma1 ,texas1 & ,wyom+ ! loss 9 #ahih 0 #add1hej4 ,( ?is am\nt1 #aag1cjj 0 attribut$ to ,colorado alone2 9 fact1 ! disord] spread s t ?is ,/ate exp5d$ m ?an #bjj1jjj 9 two ye>s & ov] #dbe1jjj 9 a p]iod ( n9e ye>s 9 attempts to eradicate ! loco plants1 ! suppos$ cause ( ! tr\ble4#b ,! loss 9 "o area ( #ce by #abj miles 9 s\?we/]n ,kansas am\nt$ to #be1jjj cattle 9 #ahhc4c ,?is loss 9 /ock has be5 s great t ! rais+ ( horses has ( necessity be5 ab&on$ 9 c]ta9 areas on acc\nt ( ! preval5ce ( ^! loco we$s4 ,x is difficult to obta9 accurate data1 z ! ran*m5 believe t any in=mation z to ! preval5ce ( ! disord] w\ld int]f]e ) ! value ( _! /ock4#d ,dr4 ,james ,flet*]1 ( ! ,c5tral ,exp]im5tal ,f>m1 ,ottawa1 ,canada1 te/ifi$ be=e ! ,select ,/&+ ,committee on ,agriculture & ,colonization t he _h nev] se5 a case 9 ! ,nor?-we/ ( a ,canadian br$ animal be+ loco$1 al?\gh ! loco plants 7 preval5t4 ,he expla9$ ?is abs5ce ( loco disease by ! abundance ( grass on ! range1 because ( :i* ! animals d n acquire ! habit ( eat+ loco plants4#e ,cases h be5 report$1 h[ev]1 9 ,manitoba4#f 99 99 99 99 99 ,,footnotes3 #a ,/alk]1 ,m4 ,! ,loco ,plant & ,its ,effect on ,animals4 ,bur4 ,animal ,indu/ry1 #c;d ,ann4 ,rept4 7#ahhf71 p4 #bga4 #ahhg4 #b ,bur4 ,animal ,indu/ry1 #f? & #g? ,ann4 ,repts4 7#ahhi & #ahij71 p4 #bgb4 #ahia4 #c ,day1 ,m4 ,g4 ,loco-,we$4 ,9 ,f4 ,p4 ,fo/]'s ,ref]5ce-,book ( ,practical ,!rapeutics1 vol4 #a1 p4 #ehg4 #ahif4 #d ,o',br9e1 ,d4 ,progress ,bullet9 on ! ,loco & ,l>kspur4 ,colo4 ,/ate ,agric4 ,coll4 ,bul4 #be1 p4 #ah4 #ahic4 #e ,flet*]1 ,j4 ,evid5ce ,be=e ! ,select ,/&+ ,comm9ttee on ,agriculture & ,colonization4 ,ottawas1 #aije1 p4 #ec4 #f ,flet*]1 ,j4 ,exp]im5tal ,f>ms ,reports = #ahib1 p4 #adh4 #ahic4 ,,plants ,,associat$ ,,) ,,! ,,loco$ ,,condition4 ,! condition kn[n z loco$ is popul>ly believ$ to be due to eat+ v>i\s plants1 especially ! memb]s ( ! ,a/ragalus & ,aragallus g5]a ( ! ,legum9os1 or pea family1 b p>ticul>ly to ,a/ragalus mollissimus & ,aragallus lamb]ti4 ,^! plants h !re=e receiv$ ! "n loco plants1#g or crazy we$4 ,b o!rs1 z ,a/ragalus mortoni1#h ,a4 hornii1 ,a4 l5tig9osus1 ,a4 patt]soni1#i ,a4 nuttallianus1 ,a4 miss\ri5sis1 ,a4 lotifloras1 ,a4 bisulcatus1 ,a4 hayd5ianus1#aj ,a4 tridactylicus1#aa ,crotal>ia sagittalis1 ,lotus am]icanus1#ab ,sophora s]icea1 ,caprioides aureum1 ,aragallus deflexa1#ac ,a4 campe/ris1#ad ,a4 lagopus1#ae ,malva/rum cocc9eum1 ,am>an?us graecizans1 & ,rhamnus lanceolata1 are consid]$ by "s z loco plants4#af ,9 o!r places ,/ipa vaseyi1 ,leucocr9um montanum1 ,fritill>ia pudica1 ,zygad5us elegans1#ag & ev5 species ( ,delph9ium are consid]$ loco plants1 s widely has ?is "n be5 us$4 ,9 ,mexico ! t]m loco$ embraces a condition due to ! action ( ,cannabis sativa & v>i\s memb]s ( ! night%ade family4 ,?is t]m has be5 mu* abus$ & has be5 made to embrace _m gr\ps ( symptoms4 ,9 fact1 if an animal dies :ile %[+ m or less /upor x is said to be loco$4#ah ,! e>ly ,spani% settl]s seem$ to be unfamili> ) ! disease1 or at lea/ ( any causative relation betwe5 ! plant & ! disease4 ,! ,spani% "n = ,a/ragalus mollissimus 0 ,g>banzillo1 f its resemblance to ,g>banzo 7,cic] ariet9um71 :i* is us$ 9 ,spa9 z a food4#ai ,! t]m z appli$ to ?is condition seems to be ( comp>atively rec5t orig94#bj ,a some:at simil> condition to ! loco 9 /ock is sometimes attribut$ by ! ran*m5 ( our ,we/]n ,/ates to eat+ v>i\s sages4#ba ,9 ,texas ! loco disease is kn[n z grass /agg]s4#bb ,hayes#bc has describ$ z foll[s a condition kn[n z grass /agg]s1 :i* app>5tly has little resemblance to loco & is suppos$ to be due to eat+ ov]ripe grass1 especially rye4 ,! symptoms1 g5]ally1 take two or ?ree days to become develop$4 ,! animal gradually becomes m or less unconsci\s & p>alyz$ & /agg]s if =c$ to walk4 ,al?\gh he may h great difficulty 9 keep+ on 8 legs1 he is extremely av]se f go+ d[n & leans = support aga9/ any conv5i5t object4 ,he brea!s 9 a snor+ mann]4 ,! muc\s membranes are t+$ ) yell[4 ,convulsions1 or spasms1 l ^? ( tetanus1 may come on4 ,recov]y may be expect$ 9 cases :i* are n m>k$ by extreme symptoms4 ,if animals are n regul>ly salt$1 !y visit salt deposits & eat ! alkalis4 ,?is "s %eepm5 believe to be ! cause ( ! loco$ condition1 b ?is is disprov$ by ! occurr5ce ( loco$ animals 9 ranges )\t salt4 ,o!rs modify ?is view by claim+ t ! vitiation 9 ta/e f eat+ ^! alkalis leads to a desire = ! loco we$s & ?us to ! loco$ condition4#bd 99 99 99 99 99 ,,footnotes3 #e ,flet*]1 ,j4 ,evid5ce ,be=e ! ,select ,/&+ ,committee on ,agriculture & ,colonization4 ,ottawa1 #aije1 p4 #ec4 #g ,sayre1 ,l4 ,e4 ,loco ,we$4 ,am]4 ,vet4 ,rev41 vol4 #aa1 p4 #eee4 #ahhg4--,/alk]1 ,m4 ,! ,loco ,plant & ,its ,effect on ,animals4 ,bur4 ,animal ,indu/ry1 #c;d ,ann4 ,report4 7#ahhf71 p4 #bga4 #ahhg4 #h ,ea/wood1 ,a4 ,! ,loco ,we$s4 ,zoe1 vol4 #c1 p4 #ec4 #ahib4 #i ,*esnut1 ,v4 ,k4 ,prelim9>y ,catalogue ( ,plants ,poison\s to ,/ock4 ,bur4 ,animal ,indu/ry1 #ae? ,ann4 ,rept4 7#ahih71 p4 #djd4 #aj ,williams1 ,t4 ,a4 ,"s ,plants ,injuri\s to ,/ock4 ,s4 ,dak4 ,agric4 ,coll4 & ,exp]4 ,/a4 ,bul4 #cc1 p4 #ba4 #ahic4 #aa ,giv5s1 ,a4 ,j4 ,loco or ,crazy ,we$4 ,m$4 ,c5tury1 vol4 #a1 p4 #bb4 #ahic4 #ab ,ea/wood1 ,a41 l4 c4 #ahib4 #ac ,sayre1 ,l4 ,e4 ,loco ,we$4 ,am]4 ,vet4 ,rev41 vol4 #aa1 p4 #eee4 #ahhg4 #ad ,am]4 ,ph>m4 ,assoc4 ,proc4 = #ahgi1 vol4 #bg1 p4 #faa4 #ahhj4 #ae ,kelsey1 ,f4 ,d4 ,ano!r ,loco ,plant4 ,bot4 ,gaz41 vol4 #ad1 p4 #bj4 #ahhi4 #af ,sayre1 ,l4 ,e4 ,loco ,we$4 ,kans4 ,/ate ,bo>d ,agric41 #e? ,bi5n4 ,rept41 p4 #bji4 #ahhg4 #ag ,&]son1 ,f4 ,w4 ,poison\s ,plants & ! ,symptoms ,!y ,produce4 ,bot4 ,gaz41 vol4 #ad1 p4 #ahj4 #ahhi4--,pammel1 ,l4 ,h4 ,loco ,we$s4 ,vis ,m$icatrix1 vol4 #a1 p4 #dd4 #ahia4 #ah ,/alk]1 ,m4 ,! ,loco ,plant & ,its ,effect on ,animals4 ,bur4 ,animal ,indu/ry1 #c;d ,ann4 ,rept4 7#ahhf71 p4 #bge4 #ahhg4--;,&]son1 ,f4 ,w4 ,poison\s ,plants & ! ,symptoms ,!y ,produce4 ,bot4 ,gaz41 vol4 #ad1 p4 #ahj4 #ahhi4 ,,note4--,! symptoms describ$ 9 ,janvi]'s int]e/+ /ory1 ,9 ,old ,mexico 7,scribn]'s ,magaz9e1 vol4 #a1 p4 #fg1 #ahhg71 w\ld co9cide ) ^? due to "s memb] ( ! night%ade family 7probably ,datura /ramonium74 ,see also ,pilgrim1 ,c4 ,w41 ,does ! ,loco ,we$ ,produce ,insanity8 9 ,proc4 ,am]4 ,m$ico-,psy*olog4 ,assoc41 vol4 #e1 p4 #afg4 #ahih4 #ai ,sayre1 ,l4 ,e4 ,loco ,we$4 ,kans4 ,/ate ,bo>d ,agric41 #e? ,bi5n4 ,rept41 p4 #bji4 #ahhg4 #bj ,/alk]1 ,m4 ,! ,loco ,plant & ,its ,effect on ,animals4 ,bur4 ,animal ,indu/ry1 #c;d ,ann4 ,rept4 7#ahhf71 p4 #bgb4 #ahhg4 #ba ,mayo1 ,n4 ,s4 ,loco4 ,! ,indu/riali/1 vol4 #cj1 p4 #dgc4 #aijd4 #bb ,sci5ce1 vol4 #i1 p4 #cb4 #ahhg4 #bc ,hayes1 ,m4 ,h4 ,vet]9>y ,notes = ,horse ,own]s1 ,london1 #aijc1 p4 #dbe4--;,comp>e ,woron91 ,m4 ,ueb] die ,taumelgetreide 9 ,sd-,ussuri54 ,bot4 ,zeit41 vol4 #di1 p4 #hj4 #ahia4 #bd ,*esnut1 ,v4 ,k41 & ,wilcox1 ,e4 ,v4 ,/ock-,poison+ ,plants ( ,montana4 ,u4 ,s4 ,dept4 ,agric41 ,div4 ,bot41 ,bul4 #bf1 p4 #hh4 #aija4 ,,note4--,! wide di/ribution ( ^! plants is claim$ to be p>tly due to ! buffalo4 ,see ,blank9%ip1 ,j4 ,w41 ,! ,loco & ,"s ,o!r ,poison\s ,plants 9 ,montana1 9 ,mont4 ,agric4 ,exp]4 ,/a4 ,bul4 #de1 p4 #gi4 #aijc4 ,,cl9ical ,,symptoms ,,( ,,loco$ ,,animals ,,z ,,describ$ ,,9 ,,lit]ature4 ,! animals usually affect$ are %eep1 horses1 cattle1 mules1#be donkeys1#bf & goats4 ,x is claim$ t practically all h]bivor\s animals are liable to ! disease1 ev5 antelopes be+ affect$4#bg ,hogs are said to be unaffect$1#bh b def9ite in=mation is lack+4 ,c[s seem to be less s5sitive to ?is =m ( intoxication4#bi ,! condition is usually a *ronic "o1 al?\gh acute cases are said to occur at times4 ,! symptoms consi/ ( dige/ive di/urbances1 associat$ ) emaciation & v>i\s symptoms sugge/+ lesions 9 ! n]v\s sy/em1 c5tral or p]iph]al4 ,! animals lose _! appetite f ! fir/1 beg9 to emaciate1 & %[ symptoms ( malnutrition & />vation4 ,! head trembles1 ! gait becomes feeble & unc]ta91 ! eyes become sunk5 & h a flat1 glassy look4#cj ,!re is a g5]al sluggi%ness1 muscul> incoord9ation1 & difficulty 9 motion2 f9ally all control ( ! limbs is lo/ & ! animal is unable to /&2 ! coat becomes r\gh & loses its lu/]1 &1 9 fact1 all ! typical symptoms ( />vation appe>4 ,9 "s cases di>rhea is also pres5t4 ,all ( ,nockolds's animals1 h[ev]1 7 con/ipat$ & ! /ools 7 cov]$ ) mucus4#ca ,! dep5d5t portions ( ! body may swell1 simply z an expression ( ! anmia4#cb ,sometimes !re are symptoms indicat+ acute pa91#cc ! animals runn+ ab\t z if affect$ ) colic4 ,!y may bel* & _! abdom5s swell4 ,"s claim t ! animals are m>k$ly salivat$ s t ! saliva trickles f _! m\?s4 ,9 o!r cases ! m\? may be dry4#cd ,! eyes may be roll$ up s t ! :ites alone %[4 ,9 "s cases ! pupil has be5 not$ to be dilat$1 z 9 atrop9e poison+1#ce b ,wilcox /ates t !y are contract$ z aft] ! use ( es]9e4#cf ,! temp]ature ( ! animal falls f #a_/b degree to #a-a_/b degrees ,f4 bel[ normal4#cg ,tetanic symptoms may occur1#ch or ! muscles ( ! m\? & tongue becom+ p>alyz$ may int]f]e ) ma/ication4 ,:5 wat] is (f]$ to ! animal1 x gazes /upidly at x & may n dr9k = days4 ,"o ( ! symptoms not$ is ! loss ( p[] to back prop]ly4#ci ,c[s dur+ ! fir/ two or ?ree mon?s ( ge/ation are almo/ sure to abort4#dj ,?is is claim$ by ,kn[les1 h[ev]1 to be due to malnutrition4 ,z a result ( ^! obs]vations1 sugge/+ "s ut]9e action1 ! drug has be5 propos$ z an emm5agogue4#da ,! psy*ical symptoms are %[n by errors ( judgm5t4 ,! animal becomes dull & spiritless & w&]s ab\t half daz$4 ,! m5tal dullness passes into /upor4 ,?is dull1 /upid condition has be5 comp>$ to intoxication ) opium4 ,if ! loco$ horse is l$ across a /ick ly+ on ! gr\nd he (t5 jumps high z if x 7 a great ob/acle4 ,! animal may n[ h maniacal attacks1 dur+ :i* he re>s & may fall backw>d1#db & makes unreasonable jumps & o!r unexpect$ movem5ts1 ?us r5d]+ himself dang]\s to man4#dc ,o!r symptoms due to di/urbances ( ! c5tral n]v\s sy/em are halluc9ations ( v>i\s sorts4 ,?\gh ! optic n]ve itself is app>5tly n affect$1 ! animal w />e at an object = a long "t )\t any app>5t compreh5sion ( its nature4 ,?is di/urbance 9 ! visual function ,mc,cullaugh claims to be "o ( ! fir/ symptoms ( ?is disease4 ,! animal seems to lose all idea ( di/ance1 z he w butt aga9/ an ob/ruction z if oblivi\s ( its pres5ce4 ,any sudd5 or viol5t motion made be=e him may cause him to fall4 ,accord+ to "s1 ! animal loses ! s5se :i* guides him 9 f9d+ wat]4 ,a c[ may fail to recognize h] calf4#dd ,!re is m or less loss ( control ( ! limbs#de & tremors2#df ! feet are lift$ abnormally high :5 trott+1 &1 if cr[d$1 ! animal falls headlong & w jump ov] little holl[s z if !y 7 wide dit*es4#dg ,! horse may %y )\t app>5t cause & kick at imag9>y objects1#dh &1 9 fact1 ! reason+ p[]s seem to be lo/4 ,^! attacks are br\ght on by sudd5 excitem5t or :5 cross+ wat]4#di ,!re may be cutane\s hyp]/hesia4 ,! animals may rema9 ) ! h]d1 b !y (t5 w&] away4 ,/alk] records ! foll[+ obs]vations3 ,i h se5 a s+le animal miles away f any o!r individual ( ! h]d1 c>efully se>*+ z if = "s lo/ object1 & :5 a loco plant is f\nd he w\ld dev\r e morsel ( x ) ! greate/ reli%4 ,z soon z "o plant 0 eat5 he w\ld imm$iately g 9 se>* ( m1 app>5tly oblivi\s to ev]y?+ b ! intoxication af=d$ by 8 "o favorite article ( food4#ej ,all ( ,nockolds's animals :i* 7 loco$ 7 m>es m ?an #f ye>s ( age4#ea ,accord+ to ,/alk] !re is a passive type 9 :i* ! animal %[s symptoms only on be+ di/urb$2 ! animal !n becomes unmanageable4 ,?is happ5s ev5 ) old1 well-brok5 saddle horses4#eb ,!re are few publi%$ reports z to ! symptoms occurr+ 9 %eep :i* are loco$4 ,/alk]#ec says %eep become loco-eat]s1 gr[ /upid1 emaciat$1 & ev5tually die4 ,"o ( ! few descriptions ( ! symptoms is t ( ,ru$i1#ed 9 :i* he claims t ! symptoms 9 %eep are ^? comp>able to ! symptoms ( c]ebro-sp9al m5+itis except t !re is an abs5ce ( fev]4 ,ru$i speaks ( %eep ly+ flat on ! gr\nd1 n able to /&1 & n able ev5 to lift _! heads to dr9k ! (f]$ wat]2 ! head & ! v]tebra 9 opi/hotonus position2 ! f\r legs /ret*$ out & /iff2 brea?+ 0 /]tor\s1 pulse sl[1 abdom5 mu* di/5d$1 di>rhea pres5t4 99 99 99 ,! he>t 99 99 99 0 v sl[ & insuffici5t4 ,! tee? 79 %eep7 may black5 & fall out4#ee ,x is ma9ly ! "y animals1 su* z lambs & colts1 t are affect$1 probably due to ! fact t _! att5tion is m easily direct$ to ! fl[] ( ! loco#ef plants4 ,x is claim$ 7on slight evid5ce7 t m5 h become loco$4 ,! symptoms 9 !m are nausea & heada*e4#eg ,s*u*>dt#eh has call$ att5tion to ! resemblance ( ! symptoms 9 loco$ animals to ^? :i* occur 9 s-call$ la?yrism1 b mo/ obs]v]s 9 ?is c\ntry h especially m>k$ ! resemblance ( ! symptoms to ^? induc$ by ! habitual use ( n>cotic drugs4#ei ,z a rule ! loco plants are refus$ by animals save :5 !re is lack ( o!r food1 al?\gh at times animals h %[n ! ke5e/ reli% = ^! plants1 reject$ all o!r =age1 & devot$ _! :ole att5tion to se>*+ = ! loco plants4#fj ,/alk] says t animals n too long addict$ to ! use ( ^! plants1 if conf9$1 soon lose _! ta/e = !m 7aft] two or ?ree mon?s71#fa al?\gh old loco eat]s d n readily lose ! habit4 ,/alk] also says t x is to be presum$ t ! plant is possess$ ( "s toxic prop]ty t has a specific effect on ! n]v\s c5t]s1 & t ^! effects h a m>k$ t5d5cy to rema9 p]man5t4#fb ,! fundam5tal "* ( ! disord] seems to be a progress+ anmia4 ,! int]pretation ( psy*ical symptoms 9 h]bivora1 & especially on ! range1 mu/ (t5 be fallaci\s4 99 99 99 99 99 ,,footnotes3 #be ,k+sley1 ,b4 ,f4 ,! ,loco ,plant4 ,daniel's ,texas ,m$ical ,j\rnal1 vol4 #c1 p4 #ebb4 #ahhh4 #bf ,s*w>tzkopff1 ,o4 ,! ,effects ( ,loco-,we$4 ,am]4 ,vet4 ,rev41 vol4 #ab1 p4 #afb4 #ahhh4 #bg ,mc,cullaugh1 ,f4 ,a4 ,loco$ ,horses4 ,j\rn4 ,comp4 ,m$4 ,vet4 ,ar*ives1 vol4 #ac1 p4 #dce4 #ahib4 #bh ,ea/wood1 ,a4 ,! ,loco ,we$s4 ,zoe1 vol4 #c1 p4 #eg4 #ahib4 #bi ,vasey1 ,g4 ,plants ,poison\s to ,cattle 9 ,cali=nia4 ,report ( ,commission] ( ,agriculture = #ahgd1 p4 #aei4 #ahge4 #cj ,vasey1 ,g41 l4 c41 p4 #aei4 #ca ,nockolds1 ,c4 ,poison+ by ,loco ,we$4 ,am]4 ,vet4 ,rev41 vol4 #bj1 p4 #egj4 #ahif-g4 #cb ,patt]son1 ,a4 ,h4 ,/>vation ,o,edema4 ,m$4 ,rev41 vol4 #ef1 p4 #gae1 #ahii4 #cc ,vasey1 ,g4 ,botanical ,notes1 ,mon?ly ,reports ( ,dept4 ,agriculture = #ahgc1 p4 #ejd4 #ahgd4 #cd ,&]son1 ,f4 ,w4 ,poison\s ,plants & ! ,symptoms ,!y ,produce4 ,bot4 ,gaz41 vol4 #ad1 p4 #ahj4 #ahhi4 #ce ,s*w>tzkopff1 ,o4 ,! ,effects ( ,loco-,we$4 ,am]4 ,vet4 ,rev41 vol4 #ab1 p4 #afa4 #ahhh4 #cf ,wilcox1 ,t4 ,e4 ,treatm5t ( ,loco ,poison+ 9 ,idaho ,t]ritory4 ,m$4 ,rec41 vol4 #ca1 p4 #bfh4 #ahhg4 #cg ,mayo1 ,n4 ,s4 ,"s ,obs]vations ,^u ,loco4 ,kans4 ,/ate ,agric4 ,coll4 ,bul4 #ce1 p4 #aah4 #ahic4 #ch ,mc,cullaugh1 ,f4 ,a4 ,loco$ ,horses4 ,j\rn4 ,comp4 ,m$4 & ,vet4 ,ar*ives1 vol4 #ac1 p4 #dcf4 #ahib4 #ci ,o',br9e1 ,d4 ,progress ,bullet9 on ! ,loco & ,l>kspur4 ,colo4 ,/ate ,agric4 ,coll4 ,bul4 #be1 p4 #ab4 #ahic4 #dj ,kn[les1 ,m4 ,e4 ,loco ,poison+4 ,bre$]s' ,gaz41 vol4 #ci1 p4 #igc4 #aija4--,sayre1 ,l4 ,e4 ,loco ,we$4 ,kans4 ,/ate ,bo>d ( ,agric41 #e? ,bi5n4 ,rept41 p4 #baa4 #ahhg4--,ru$i1 ,c4 ,loco ,we$4 ,trans4 ,colo4 ,/ate ,m$4 ,soc41 p4 #dbb4 #ahie4 #da ,mill]1 ,c4 ,h4 ,! ,loco ,we$3 ,its ,probable ,usefulness z an ,emm5agogue4 ,s\!rn ,cl9ic1 vol4 #aa1 p4 #bfi4 #ahhh4 #db ,vasey1 ,g4 ,botanical ,notes4 ,mon?ly ,reports ( ,dept4 ,agriculture = #ahgc1 p4 #ejd4 #ahgd4 #dc ,p>k]1 ,w4 ,t4 ,! ,loco-,we$4 ,sci5ce1 vol4 #bc1 p4 #aja4 #ahid4 #dd ,vasey1 ,g4 ,botanical ,notes4 ,mon?ly ,reports ( ,dept4 ,agriculture = #ahgd1 p4 #eac4 #ahge4 #de ,&]son1 ,f4 ,w4 ,poison\s ,plants & ! ,symptoms ,!y ,produce4 ,bot4 ,gaz41 vol4 #ad1 p4 #ahj4 #ahhi4 #df ,sayre1 ,l4 ,e4 ,loco ,we$4 ,proc4 ,am]4 ,ph>m4 ,assoc41 vol4 #cf1 p4 #aaa4 #ahhh4 #dg ,nockolds1 ,c4 ,poison+ by ,loco ,we$4 ,am]4 ,vet4 ,rev41 vol4 #bj1 p4 #egj4 #ahif-g4 #dh ,kn[les1 ,m4 ,e4 ,loco ,poison+4 ,bre$]s' ,gaz41 vol4 #ci1 p4 #igb4 #aija4 #di ,vasey1 ,g4 ,botanical ,notes4 ,mon?ly ,reports ( ,dept4 ,agriculture = #ahgc1 p4 #ejd4 #ahgd4 #ej ,/alk]1 ,m4 ,! ,loco ,plant & ,its ,effect on ,animals4 ,bur4 ,animal ,indu/ry1 #c;d ,ann4 ,rept4 7#ahhf71 p4 #bgb4 #ahhg4--,nockolds1 ,c4 ,poison+ by ,loco ,we$4 ,am]4 ,vet4 ,rev41 vol4 #bj1 p4 #egj4 #ahif-g4--,mais*1 ,j4 ,m4 ,poison\s ,species ( ,a/ragalus4 ,am]4 ,j\rn4 ,ph>m41 vol4 #ea1 p4 #bci4 #ahgi4 #ea ,nockolds1 ,c4 ,poison+ by ,loco ,we$4 ,am]4 ,vet4 ,rev41 vol4 #bj1 p4 #egj4 #ahif-g4 #eb ,/alk]1 ,m41 l4 c41 p4 #bgc4 #ec ,/alk]1 ,m41 l4 c41 p4 #bgd4 #ed ,ru$i1 ,c4 ,loco ,we$ 7,a/ragalus ,mollissimus73 ,a ,toxico-,*emical ,/udy4 ,trans4 ,colo4 ,/ate ,m$4 ,soc41 #ahie1 p4 #dag4 #ee ,blank9%ip1 ,j4 ,w4 ,loco & ,"s ,o!r ,poison\s ,plants 9 ,montana4 ,mont4 ,agric4 ,exp]4 ,/a4 ,bul4 #de1 p4 #ha4 #aijc4 #ef ,blank9%ip1 ,j4 ,w41 l4 c4 #eg ,day1 ,m4 ,g4 ,loco-,we$4 ,9 ,f4 ,p4 ,fo/]'s ,ref]5ce ,book ( ,practical ,!rapeutics1 vol4 #a1 p4 #ehh4 #ahif4--,pilgrim1 ,c4 ,w4 ,does ! ,loco-,we$ ,produce ,insanity8 ,proc4 ,am]4 ,m$ico-,psy*olog4 ,assoc41 vol4 #e1 p4 #afg4 #ahih4 #eh ,s*u*>dt1 ,b4 ,die ,loco-,krankheit d] ,pf]de und des ,r9dviehs4 ,deuts*4 ,zeits4 f4 ,?i]m$41 vol4 #ah1 p4 #dje4 #ahib4--,p>k]1 ,w4 ,t4 ,loco-,we$4 ,sci5ce1 vol4 #bc1 p4 #aja4 #ahid4 #ei ,mc,cullaugh1 ,f4 ,a4 ,loco$ ,horses4 ,j\rn4 ,comp4 ,m$4 & ,vet4 ,ar*ives1 vol4 #ac1 p4 #dce4 #ahib4 #fj ,/alk]1 ,m4 ,! ,loco ,plant & ,its ,effect on ,animals4 ,bur4 ,animal ,indu/ry1 #c;d ,ann4 ,rept4 7#ahhf71 p4 #bgb4 #ahhg4 #fa ,/alk]1 ,m4 ,! ,loco ,plant & ,its ,effect on ,animals4 ,bur4 ,animal ,indu/ry1 #c;d ,ann4 ,rept4 7#ahhf71 p4 #bgb4 #ahhg4--,see also ,l9field1 ,f4 ,b4 ,%eep ,fe$+1 9 ,mont4 ,agric4 ,coll4 ,exp]4 ,/a4 ,bul41 #ei4 #aije4--,special ,report on ,diseases ( ,cattle4 ,bur4 ,animal ,indu/ry1 #aijd1 p4 #ff4--,wilcox1 ,e4 ,v4 ,plant ,poison+ ( ,/ock 9 ,montana4 ,bur4 ,animal ,indu/ry1 #ag? ,ann4 ,rept41 p4 #aae4 #aijj4 #fb ,/alk]1 ,m41 l4 c41 p4 #bge4 ,,conditions ,,simil> ,,to ,,loco-,,we$ ,,poison+ ,,9 ,,o!r ,,p>ts ,,( ,,! ,,_w4 ,accord+ to ,maid5#fc a condition simil> to loco is met ) among animals 9 ,au/ralia & is !re believ$ to be due to eat+ v>i\s species ( ,swa9sona4#fd ,z ,maid5 says1 ,its effect on %eep is well kn[n2 !y sep>ate f ! flock1 w&] ab\t li/lessly1 & are kn[n to ! %eph]ds z 'pea-eat]s' or 'indigo-eat]s4' ,:5 once a %eep takes to eat+ ?is plant x seldom or nev] fatt5s1 & may be said to be lo/ to its own]4 ,horses1 aft] eat+ ?is h]b1 7 exceptionally difficult to cat*1 & x 0 obs]v$ h[ /range !y appe>$4 ,_! eyes 7 />+ out ( _! heads & !y 7 pranc+ aga9/ trees & /umps4 ,! second day two out ( n9e di$1 & five o!rs _h to be left at ! camp4 ,m>t9#fe exp]im5tally /udi$ ^! cases ( intoxication & sums up 8 "w z foll[s3 #a4 ,t "o c by fe$+ %eep ^u ,d>l+ pea reproduce all ! symptoms :i* are attribut$ by pa/orali/s to ?is cause4 ,briefly /at$ ^! symptoms are3 ,/upidity1 loss ( al]tness & an agoniz$ expression1 foll[$ by /iffness & slight /agg]+ & frequ5tly trembl+ ( ! head or limbs4 ,lat]1 clums9ess & un/ead9ess ensue1 :i* sl[ly advance until ! animal (t5 falls d[n4 ,9 ?is /age1 ! action ( ! animal 9 runn+ ov] small ob/acles is *>act]i/ic4 ,x jumps ov] a twig z if x 7 a foot 9 height4 ,:5 fir/ x comm5ces to tumble ab\t1 x is able m or less readily to rega9 its feet1 b 9 ! advanc$ /age ( ! disease ?is is impossible &1 aft] exhau/+ itself 9 ef=ts to d s1 x rema9s ly+ d[n until x dies4 ,dur+ ! :ole "t ! %eep become progressively m bloodless1 & 9 advanc$ cases ! blood :5 %$ appe>s to ! nak$ eye light] 9 color4 ,x conta9s few] r$ blood-cells 7ab\t two-?irds to "o-half ! usual numb]74 7,! corpuscles 7 e/imat$ 9 sev]al cases by means ( a hmocytomet]47 ,all ^! symptoms are mu* aggravat$ by driv+4 ,?us1 an animal 9 :i* ! symptoms are little m>k$ may exhibit !m 9 a /rik+ degree aft] be+ driv54 ,9 addition to ! above ! tee? 7especially 9 "y %eep7 frequ5tly become loose1 & consequ5tly displac$ or ev5 dislodg$4 #b4 ,t ! "t :i* elapses be=e ! onset ( def9ite symptoms is ?ree to f\r weeks 9 %eep ( #b to #c ye>s old4 7,x is probable1 h[ev]1 t ) y\ng] animals ! "t is %ort]47 #c4 ,t "u ! conditions ( ! exp]im5t1 ! animals surviv$ ab\t ?ree mon?s4 ,!y liv$1 h[ev]1 an invalid's life4 ,ev]y?+ 0 br\ght to !m1 & x is improbable t if fe$+ exclusively ^u ! pea1 & left to %ift = !mselves 9 ! paddocks1 !y w\ld survive m ?an two mon?s4 #d4 ,t if a %eep be return$ to prop] fodd] aft] "o mon? to six weeks fe$+ ^u ! pea1 & be=e ! symptoms are fully e/abli%$1 x may recov] completely4 #e4 ,t :5 once ! p>alytic symptoms are e/abli%$ x w n recov]2 b if return$ to prop] food1 w rema9 9 mu* ! same condition1 becom+ nei!r bett] nor worse4 #f4 ,t ,d>l+ pea conta9s a v fair am\nt ( n\ri%+ mat]ial s t animals may1 provid$ !y eat x readily1 reta9 _! condition on x = "s weeks1 until ! poison\s pr9ciple conta9$ has _h "t to ex]t its effects4 ,^! plants1 if f$ ) o!r h]bage1 d n seem to be injuri\s & app>5tly lose _! h>mful action ^u be+ cultivat$4#ff ,z long z salt is prop]ly f$ ! animals w n eat ?is plant#fg & are said to suff] no effects f x4 ,physiological /udy has %[n ! pres5ce ( a body ) m>k$ sudorific p[] :i* causes rapid emaciation 9 frogs4#fh ,x has be5 claim$ t ^! symptoms are due to ! pres5ce ( a n>cotic poison 9 ! plant4#fi ,po/-mortem exam9ations 7 negative save = ! pres5ce ( a p]iph]al neuritis4#gj 99 99 99 99 99 ,,footnotes3 #fc ,maid51 ,j4 ,h4 ,plants ,reput$ to be ,poison\s to ,/ock 9 ,au/ralia4 ,dept4 ,agric41 ,new ,s\? ,wales1 ,misc4 ,pub4 ,no4 #dgg1 pp4 #ae1 #af4 #aija4 #fd ,notes on ,"s ,am]ican & ,au/ralian ,plants ,injuri\s to ,/ock4 ,agric4 ,gaz41 ,new ,s\? ,wales1 vol4 #d1 p4 #fgg4 #ahid4--,notes on ,we$s4 ,! ,d>l+ ,pea4 ,agric4 ,gaz41 ,new ,s\? ,wales1 vol4 #c1 p4 #ccj4 #ahic4 #fe ,m>t91 ,c4 ,j4 ,report on an ,inve/igation into ! ,effects ( ,d>l+ ,pea 7,swa9sona ,galegifolia7 ^u ,%eep4 ,agric4 ,gaz41 ,new ,s\? ,wales1 vol4 #h1 p4 #cff4 #ahih4 #ff ,woolls1 ,w4 ,on ! ,=age-,plants ,indig5\s 9 ,new ,s\? ,wales4 ,l9n4 ,soc41 ,new ,s\? ,wales1 ,proc41 vol4 #g1 pp4 #cae-caf4 #ahhb4 #fg ,gu?rie1 ,f4 ,b41 & ,turn]1 ,f4 ,suppos$ ,poison\s ,plant4 ,agric4 ,gaz41 ,new ,s\? ,wales1 vol4 #d1 p4 #hf4 #ahid4 #fh ,bailey1 ,f4 ,m41 & ,gordon1 ,p4 ,r4 ,plants ,reput$ ,poison\s & ,injuri\s to ,/ock1 ,brisbane1 #ahhg1 p4 #be4 #fi ,gu?rie1 ,f4 ,b41 & ,turn]1 ,f4 ,suppos$ ,poison\s ,plant4 ,agric4 ,gaz41 ,new ,s\? ,wales1 vol4 #d1 p4 #hg4 #ahid4 #gj ,m>t91 ,c4 ,j4 ,report on ! ,inve/igation into ! ,effects ( ,d>l+ ,pea 7,swa9sona ,galegifolia7 ^u ,%eep4 ,agric4 ,gaz41 ,new ,s\? ,wales1 vol4 #h1 p4 #cfg4 #ahih4 7,fur!r lit]ature on ! indigo disease w be f\nd 9 ,bailey1 ,f4 ,m41 & ,gordon1 ,p4 ,r4 ,plants ,reput$ ,poison\s & ,injuri\s to ,/ock1 ,brisbane1 #ahhg1 p4 #be74 ,,note4--,9 ,canada a *ronic disease associat$ ) cirrhosis ( ! liv] results f eat+ ragwort1 or ,s5ecio jacobaea4 ,see ,dept4 ( ,agriculture1 ,canada1 ,rept4 ( ,vet]9>y ,director ,g5]al1 #aije1 ,ottawa1 #aijf1 p4 #ca4--;,9 ,s\? ,africa a disord] kn[n z n5ta appe>s 9 goats aft] eat+ c]ta9 plants1 especially ,cotyl$on v5tricosa4 ,see ,hut*eon1 ,d41 ,n5ta1 9 ,agric4 ,j\rn4 ,cape ( ,good ,hope1 vol4 #ad1 p4 #hfb4 #ahii4 ,,pa?ological ,,conditions ,,9 ,,loco$ ,,animals ,,z ,,describ$ ,,on ,,! ,,range4 ,! pa?ological features z describ$ by previ\s writ]s are a s(t5+ & ulc]ation ( ! /oma* walls#ga & a deg5]ation ( ! walls ( ! inte/9es ) or )\t p]=ations4 ,! p]itoneum may be f\nd inflam$4#gb ,! p]itoneum & om5tum 9 "o case 7c[71 report$ by ,sayre1 7 cov]$ ) small nodules4 ,^! 7 probably tub]cul> 9 orig94 ,! colon 9 "o horse 0 f\nd enorm\sly di/5d$1 :ile ! coecum & small inte/9es 7 normal1#gc save t ! walls appe>$ ?94 ,ulc]s h be5 f\nd at times 9 ! kidneys1 b 7 probably second>y 9 orig91 z o!r cases are report$ ) normal kidneys4 ,faville has f\nd 9 "s cases amyloid deg5]ation4 ,! pancreas & sple5 are report$ normal4 ,! abdom9al cavity may conta9 a slight effusion4#gd ,! liv] has be5 f\nd cirrhotic1 & at times %[s tub]cul> lesions ( a second>y nature4 ,! inn] coat ( ! bladd] has be5 f\nd s(t5$1 & 9 %eep ! bladd] may be m>k$ly di/5d$ at ! autopsy4 ,! c]ebral membranes are conge/$ & p]haps adh]5t1#ge & !re may be blood clots ov] ! longitud9al s9us or at ! base ( ! bra94 ,effusions h be5 especially not$ ar\nd ! m$ulla4 ,! ara*noid has also %[n slight conge/ion1 & 9 o!r cases ! membranes %[$ a slight ?ick5+4 ,! middle v5tricle 0 f\nd fill$ ) yell[ s]um1 :ile ! f\r? v5tricle conta9$ a hemorrhagic effusion1#gf & ! base ( ! bra9 0 cov]$ by a clot4 ,! hemorrhage may become organiz$ & ! bra9 be held to ! membranes by t\gh organiz$ fib]s4 ,9 _m cases s]\s effusion is pres5t 9 ! lat]al v5tricles4 ,! ara*noid space is also 9 "s cases simil>ly fill$4 ,microscopic exam9ation ( ! bra9 9 ! case ( a /e] %[$ atrophy ( ,purk9jie's cells4#gg ,9 %eep ! po/-mortem exam9ation %[$ pal5ess1 anmia ( ! muscles1 & great di/5tion ( ! abdom54 ,! inte/9es 7 f\nd fill$ ) gases1 & ! mes5t]ic blood vessels fill$ ) blood4 ,no p]itonitis1 or ascites1 or ec*ymoses 9 ! muc\s membranes 7 not$ 9 ! autopsies made on %eep by ,ru$i4 ,! liv] has be5 se5 enl>g$4 ,9 %eep ! bra9 0 anmic4 ,microscopically ! bra9 %[$ atrophy & ! ,purk9jie's cells disappe>$ or _! processes atrophi$4 ,9 ^! %eep ! bra9 0 s anmic t ! di/9ction betwe5 ! gray & ! :ite matt] 0 h>d to def9e4#gh ,! membranes ( ! cord h be5 f\nd inflam$ & adh]5t1 b ! sp9al cord 0 usually normal4#gi ,9 "s cases1 h[ev]1 ! sp9al cord has be5 f\nd s(t5$#hj & o$emat\s4 ,! art]ies ( ! limbs 7 gorg$ ) blood1#ha & at ! same "t !re 0 a collection ( s]um 9 ! abdom9al cavity4 ,dea? is ?\ght to be due to />vation4#hb ,9 o!r words1 ! pa?ological condition1 accord+ to publi%$ acc\nts1 %[s little t is *>act]i/ic save "s action on ! ga/ro-inte/9al tract4 99 99 99 99 99 ,,footnotes3 #ga ,&]son1 ,f4 ,w4 ,poison\s ,plants & ! ,symptoms ,!y ,produce4 ,bot4 ,gaz41 vol4 #ad1 p4 #ahj4 #ahhi4 #gb ,sayre1 ,l4 ,e4 ,loco ,we$4 ,am]4 ,vet4 ,rev41 vol4 #aa1 p4 #eeh4 #ahhg4 #gc ,o',br9e1 ,d4 ,progress ,bullet9 on ! ,loco & ,l>kspur4 ,colo4 ,/ate ,agric4 ,coll4 ,bul4 #be1 p4 #ab4 #ahic4 #gd ,faville1 9 ,o',br9e1 ,d4 ,progress ,bullet9 on ! ,loco & ,l>kspur4 ,colo4 ,/ate ,agric4 ,coll4 ,bul4 #be1 p4 #aa4 #ahic4 #ge ,sayre1 ,l4 ,e4 ,loco ,we$4 ,am]4 ,vet4 ,rev41 vol4 #aa1 p4 #eei4 #ahhg4 #gf ,/alk]1 ,m4 ,! ,loco ,plant & ,its ,effect on ,animals4 ,bur4 ,animal ,indu/ry1 #c;d ,ann4 ,rept4 7#ahhf71 p4 #bgd4 #ahhg--,sayre1 ,l4 ,e4 ,loco-,we$4 ,am]4 ,ph>m4 ,assoc4 ,proc41 vol4 #ch1 p4 #ajh4 #ahij4--,o',br9e1 ,d4 ,progress ,bullet9 on ! ,loco & ,l>kspur4 ,colo4 ,/ate ,agric4 ,coll4 ,bul4 #be1 pp4 #af1 #ag4 #ahic4 #gg ,mayo1 ,n4 ,s41 l4 c41 p4 #aah4 #gh ,ru$i1 ,c4 ,loco ,we$ 7,a/ragalus ,mollissimus73 ,a ,toxico-,*emical ,/udy4 ,trans4 ,colo4 ,/ate ,m$4 ,soc41 #ahie1 p4 #dah4 #gi ,sayre1 ,l4 ,e4 ,loco ,we$4 ,am]4 ,vet4 ,rev41 vol4 #aa1 p4 #eei4 #ahhg4 #hj ,o',br9e1 ,d4 ,progress ,bullet9 on ! ,loco & ,l>kspur4 ,colo4 ,/ate ,agric4 ,coll4 ,bul4 #be1 p4 #ab4 #ahic4--,kl5*1 ,j4 ,p4 ,rattlewe$ or ,loco ,disease4 ,am]4 ,vet4 ,rev41 vol #ab1 p4 #cii4 #ahhh4 #ha ,&]son1 ,f4 ,w4 ,poison\s ,plants & ! ,symptoms ,!y ,produce4 ,bot4 ,gaz41 vol4 #ad1 p4 #ahj4 #ahhi4 #hb ,mc,cullaugh1 ,f4 ,a4 ,loco$ ,horses4 ,j\rn4 ,comp4 ,m$4 & ,vet4 ,ar*ives1 vol4 #ac1 p4 #dcf4 #ahib4 ,,hi/orical ,,sket* ,,( ,,loco ,,inve/igations ,,f ,a ,,ph>macological ,,/&po9t4 ,dur+ ! we/]n immigration ( #ahdi ! ,indians along ! ,miss\ri ,riv] describ$ to ! immigrants a plant 7,a/ragalus mollissimus7 produc+ dea? 9 horses & cattle1 :i* 0 prec$$ by v>i\s =ms ( excitem5t4#hc ,! att5tion ( ! ,unit$ ,/ates ,dep>tm5t ( ,agriculture 0 fir/ call$ to ! toxic action ( ! loco plants 9 #ahgc1 :5 specim5s ( ! plants1 :i* 7 id5tifi$ z ,a/ragalus hornii & ,a4 l5tig9osus1#hd 7 s5t f ,cali=nia by ,mr4 ,o4 ,b4 ,ormsby1 ) ! /atem5t t !y 7 poison\s to /ock1 especially to horses4 ,mrs4 ,j4 ,s4 ,:ipple also corroborat$ ?is in=mation4 ,! botani/ ( ! ,dep>tm5t1 ,dr4 ,george ,vasey1#he publi%$ a note & reque/$ fur!r in=mation conc]n+ ! plants4 ,^! notes 7 enl>g$ by a simil> contribution by ,dr4 ,p4 ,m(fat on ,aragallus lamb]ti4#hf ,! foll[+ ye> ,vasey report$ ) m fullness1 & 8 description ( ! action ( ! plants is sub/antially :at we f9d 9 mo/ ( ! books ( to-day4 ,9 #ahgf ,lemmon#hg not$ t ,a/ragalus mortoni 0 a deadly %eep poison4 ,at ! same "t ,ro?rock1#hh botani/ ( ! ,unit$ ,/ates ,geographical ,survey "u ,lieut5ant ,:eel]1 describ$ ^! plants1 & ,kellogg1#hi a botani/ 9 ,cali=nia1 report$ t ,a/ragalus m5ziesii 0 caus+ great losses 9 horses1 %eep1 & cattle & claim$ t ! /ockm5 _h be5 famili> ) ?is disord] = at lea/ t5 or fifte5 ye>s4 ,?is report ( ,kellogg 0 foll[$ by t ( ,ro?rock#ij 9 #ahgg4 ,9 #ahgf a specim5 ( ,aragallus lamb]ti 0 s5t f ,colorado to ,pr(essor ,prescott1 ( ! ,univ]sity ( ,mi*igan1 "u ! "n ( crazy we$1 ) ! /atem5t t x 0 poison\s to horses & cattle & t1 :ile ! ,mexicans (t5 us$ x 9 mak+ be]1 x sometimes caus$ symptoms 9 m54 ,8 pupil1 ,miss ,watson1 und]took a /udy ( its *emical prop]ties4 ,%e fail$ to isolate any pure *emical comp\nd1 b claim$ t 9 ! root !re 0 a body giv+ alkaloidal reactions & t !re 0 also a res9\s body pres5t4 ,ano!r ( 8 pupils1 ,w4 ,r4 ,birdsall1 took ! gr\nd-up root himself 9 doses ( #bj gra9s at v>i\s int]vals = sev]al days & lat] #dj-;gra9 doses 9 "o & a half h\rs1 b )\t exp]i5c+ any m>k$ symptoms except colicky pa9s4 ,a kitt5 also 0 giv5 ab\t "o & a half ounces ( ! fluid extract )\t effect4 ,prescott#ia sums up by say+ t x w\ld seem t ! dri$ gr\nd root possesses no poison\s prop]ties4 ,! "w ( ,miss ,watson 0 consid]$ ( suffici5t importance to be ab/ract$ 9 ! ,annual ,report ( ! ,commission] ( ,agriculture = #ahgh 7#ahgi71 page #acd4 ,gradually ! ,dep>tm5t ( ,agriculture became m & m int]e/$ 9 ?is subject1 & ,pet] ,colli]1 *ief *emi/1 9 #ahgh1 exam9$ ! roots & leaves ( ,aragallus lamb]ti = alkaloids1 b f\nd none4#ib ,9 #ahhj ,pet] ,colli] publi%$ a proximate analysis ( ,a/ragalus mollissimus made by ,francis ,a4 ,w5tz1 ( ,kansas4 ,8 inve/igations %[$ x to h an a% cont5t ( #f4gf p] c5t1 :ile ! ,aragallus lamb]ti1 analyz$ by ,l4 ,f4 ,dyr5=?1 ( ,*icago1 %[$ an a% cont5t ( #d4cb p] c5t4 ,colli]#ic sums up by say+3 ,f ! additional "w done at ?is ,dep>tm5t x seems probable t ! delet]i\s effects obs]v$ f animals eat+ ?is plant may be due pr9cipally to ! fact t ! sweet ta/e causes cattle to reject m nutriti\s food & /rive to subsi/ ^u ! ,oxytropis only4 ,?is plant is me*anically a v unfit sub/ance = food1 be+ ( a t\gh1 fibr\s1 & indige/ible "*4 ,x is possible t1 :5 ! animal becomes some:at enfeebl$ by lack ( prop] n\ri%m5t1 ! small am\nt ( alkaloid may h a direct poison\s action4 ,aga91 x seems probable t ! plant may conta9 mu* l>g] proportions ( alkaloid at c]ta9 /ages 9 its developm5t ?an at o!rs1 or ! se$s may prove to be ! mo/ injuri\s portion4 ,! dep>tm5tal "w 0 cont9u$ by fur!r %ort notices by ,vasey#id 9 #ahhd1 #ahhf1 & #ahhg1 & by ! report ( ,/alk] 9 #ahhg4 ,?is report by ,/alk] is /ill ! be/ description on ! cl9ical side ( ! "q4 ,ro?rock1#ie meet+ ! loco plants 9 8 survey "w1 describes _! effects on animals z foll[s3 ,c]ta9 x is1 h[ev]1 t1 once comm5c$1 !y cont9ue x1 pass+ ?r\gh tempor>y intoxication to a complete n]v\s & muscul> wreck 9 ! lat] /ages1 :5 x has develop$ into a fully m>k$ disease :i* t]m9ates 9 dea? f />vation or inability to dige/ a m n\ri%+ food4 ,! animal t[>d ! la/ becomes /upid or wild1 or ev5 vici\s1 or1 aga91 act+ z ?\gh attack$ ) bl9d /agg]s4 ,"u ! "n ( ,crotal>ia1 ,h4 ,gibbons1#if 9 #ahgi1 ref]s to a plant gr[+ 9 ,cali=nia :i* x 0 claim$ 0 produc+ *>act]i/ic symptoms ( poison+ 9 horses & %eep4 ,?is plant ,pr(essor ,mais* aft]w>ds id5tifi$ z ,aragallus lamb]ti4 ,dr4 ,isaac ,ott#ig und]took ! physiological /udy ( ! "q & us$ an alcoholic extract ( ,a/ragalus mollissimus4 ,he f\nd f its action on frogs1 rabbits1 & cats t ! plant _h decid$ physiological action1 z foll[s3 7#a7 ,x decreases ! irritability ( ! motor n]ves4 7#b7 ,greatly affects ! s5sory ganglia ( ! c5tral n]v\s sy/em1 prev5t+ !m f readily receiv+ impressions4 7#c7 ,has a sp9al tetanic action4 7#d7 ,kills ma9ly by arre/ ( ! he>t4 7#e7 ,increases ! saliv>y secretion4 7#f7 ,has a /upefy+ action on ! bra94 7#g7 ,r$uces ! c>diac =ce & frequ5cy4 7#h7 ,tempor>ily increases art]ial t5sion1 b f9ally decreases x4 7#i7 ,x greatly dilates ! pupil4 ,doctor ,/ockman1 9 ,engl&1 ab\t ?is "t tri$ ! action ( ! aque\s & alcoholic extracts ( ! dri$ ,a/ragalus mollissimus s5t f ,texas4 ,he exp]im5t$ ) frogs & rabbits 9 increas+ doses1 b )\t result4#ih ,9 #ahhh ,hill report$ t a species ( ,a/ragalus 0 act+ detrim5tally on cattle1 goats1 & %eep 9 ,cyprus & t ^! animals fell d[n z if intoxicat$1 & also t ! natives 9 "t ( great dr\ght fe$ _! cattle ) ?is plant mix$ ) /raw1 b t !y 7 always made sick until !y became us$ to x4 ,9 #ahhe ,pr(essor ,sayre1 ( ! ,univ]sity ( ,kansas1 und]took ! inve/igation ( ! loco "q4 ,8 fir/ report 0 made 9 ! ,transactions ( ! ,kansas ,academy ( ,sci5ces = #ahhe1 & 8 reports h be5 cont9u$ at v>i\s p]iods up to #aijd4 ,! results ( 8 exp]im5ts on v>i\s animals--dogs1 cats1 & frogs#ii--;h be5 entirely negative4 ,he adm9i/]$ alcoholic prep>ations to himself & took !m until !y became too nause\s to cont9ue1 & f\nd !y produc$ absolutely no symptoms besides ! nausea4 ,he sugge/s1 h[ev]1 t if ! plant really is poison\s x is due to its f9e hairs1 :i* might me*anically cause dea?4 ,sayre has /at$ t he has s5t ?\s&s ( p\nds ( ! dri$ loco plants to v>i\s inve/igators 9 ,am]ica & ,europe1 b all reports 7 negative z to ph>macological activity4 ,he has1 h[ev]1 done "s "w on ! pure *emi/ry ( ! plant & f\nd t ! plant conta9$ #aj p] c5t ( moi/ure & yield$ #ab4ja p] c5t ( a%4 ,( ?is a%1 #be p] c5t 0 soluble 9 wat]1 :ile #ej4f p] c5t 0 soluble 9 ,h,cl4 ,! insoluble portion consi/$ l>gely ( silica4 ,he f\nd ,ca,o1 ,k#b,o1 ,mg,o1 ,al#b,o#c1 & ,fe#b,o#c1 ) ! acid radicals ,,s#c1 ,cl1 ,p#b,o#e1 ,,co#b1 & ,si,o#b4ajj ,al?\gh ,sayre claims t ! plant is physiologically inactive1 he tri$ by *emical means to isolate a physiologically active body &1 naturally en\gh "u ! circum/ances1 fail$ to f9d "o4 ,he claims t :ile ! plant might give alkaloid reactions1 he 0 unable to isolate ?is body 9 a pure /ate1 & t alfalfa react$ simil>ly4 ,! inve/igation on animals 0 cont9u$ by ,k5n$y4#aja ,he adm9i/]$ an infusion ( #a_/b ounce ( gre5 ,a/ragalus mollissimus to a fa/+ dog weigh+ #bc p\nds1 b !re 7 no symptoms aft] #ab h\rs4 ,a decoction ( #a ounce ( ! gre5 plant & "o ( #d ounces ( ! dri$ plant 7 likewise )\t action4 ,extracts ) hydro*loric acid 7 also inactive4 ,:5 #djj grams ( ! dri$ & p[d]$ plant 7 f$ 9 sub/ance ! result 0 m]ely to increase ! appetite4 ,! organic acid obta9$ f #d ounces ( ! plant 0 also f\nd to be in]t4 ,k5n$y did n /ate 9 :at season ! plant 0 collect$ & f :at locality x 0 obta9$1 b says simply t ! plant extract 0 inactive to a dog1 a c>nivor\s animal1 & t !re=e ! plant is nonpoison\s4 ,he adds t dea? might be due to ! t\gh fib]s & indige/ible "* ( ! plant4 ,he ov]looks1 h[ev]1 ! fact t ! plant might v>y 9 its toxicity1 & he inf]s f ! exp]im5ts on c>nivor\s animals t ^! results w\ld hold good = h]bivora1 yet he does n claim t c>nivora become loco$ 9 nature4 ,k5n$y f\nd t ! plant lo/ #hj p] c5t 9 weight on dry+ & t ! wat] extract :i* repres5t$ #cj4f p] c5t ( ! p[d]$ & dri$ plant conta9$ magnesium sulphate & sodium *lorid1 tannic acid1 gum1 color+ matt]1 an extractive1 & a peculi> organic acid4 ,! a%$ plant yield$ #bj p] c5t ( a%1 consi/+ ( magnesium sulphate1 sodium *lorid1 alum9a1 silica1 & a trace ( iron4 ,! abundant precipitate produc$ by ! alkal9e hydrates1 potassium1 sodium1 & ammonium 0 f\nd to consi/ ( magnesium hydrate1 an abundance ( ?is base be+ pres5t 9 ! plant4 ,k5n$y also obta9$ alkaloidal reactions1 b fail$ to isolate ! body giv+ ^! reactions4 ,9 #ahhi ! inve/igations 7 greatly /imulat$ by ! report ( ,doctor ,day1#ajb !n ( ! ,univ]sity ( ,mi*igan4 ,%e claim$ t %e 0 able to produce m>k$ physiological symptoms1 us+ bo? ,a/ragalus mollissimus & ,aragallus lamb]ti 9 h] "w4 ,%e adm9i/]$ daily #fj to #gj c4c4 ( a decoction#ajc ( ! plants to kitt5s1 toge!r ) abundant milk & o!r food4 ,%e /ates t 9 two days-- ,! kitt5s became less active1 ! coat grew r\gh1 appetite = ord9>y food dim9i%$ & fondness = ! loco increas$1 di>rhea came on1 & ret*+ & vomit+ occasionally occurr$4 ,! expression became peculi> & *>act]i/ic4 ,emaciation & ! above symptoms progressively increas$ until ! eighte5? day1 :5 p]iods ( convulsive excitem5t sup]v5$4 ,at times ! convulsions 7 tetanic 9 "*2 fro?+ at ! m\? & ?r[+ ! head backw>d z 9 opi/hotonus 7 m>k$4 ,at o!r times ! kitt5 w\ld /& on its h9d legs & /rike ! air ) its =epaws1 !n fall backw>d & ?r[ itself f side to side4 ,^! p]iods ( excitem5t 7 foll[$ by p]fect quiet1 ! only app>5t sign ( life be+ ! respiratory movem5ts4 ,aft] a %ort int]val ( quiet ! convulsive movem5ts w\ld recur4 ,^! alt]nate p]iods ( excitem5t & quiet la/$ ?irty-six h\rs1 :5 ! po/]ior extremities became p>alyz$1 & ! kitt5 di$ ab\t two h\rs aft]w>d4 ,!re 0 no app>5t loss ( consci\sness be=e dea?4 ,! po/-mortem exam9ation reveal$ ! pres5ce ( ulc]s 9 ! /oma* & duod5um4 ,"s ( ! ulc]s _h ne>ly p]=at$ ! walls ( ! /oma* & duod5um4 ,! he>t 0 9 dia/ole2 bra9 & myel appe>$ normal4 ,z might be expect$ f ! emaciat$ condition1 ! entire body 0 anmic4 ,9 a second case #fj to #gj cubic c5timet]s ( a m conc5trat$ decoction 7 f$ daily1 ) o!r food z be=e1 to a vigor\s adult cat4 ,! symptoms ( inactivity1 loss ( appetite1 r\gh coat1 di>rhea1 & ! peculi> expression ( c\nt5ance 7 z 9 ! fir/ case4 ,by ! twelf? day ! cat 0 wa/$ almo/ to a skeleton1 & 0 correspond+ly weak4 ,p>alysis ( ! h9d limbs came on1 & ! cat di$ on ! ?irte5? day4 ,!re 7 no p]iods ( excitem5t 9 ?is case4 ,^! cats develop$ a crav+ = ! decoction & w\ld beg = x z an ord9>y kitt5 does = milk1 & :5 suppli$ w\ld lie d[n cont5t$4 ,doctor ,day made controls ) heal?y animals "u ! same conditions1 ) ! exception t !y receiv$ no loco plant4 ,%e also f$ a "y wild jack rabbit on milk & grass = a few days & !n sub/itut$ fre% loco plants = grass4 ,at fir/ ! loco 0 refus$1 b aft] two or ?ree days ! loco 0 eat5 ) z mu* reli% z ! grass _h be54 ,aft] t5 days ( ! milk & loco diet ! rabbit 0 f\nd dead1 ) ! head ?r[n back & ! /oma* ruptur$4 ,subcutane\s injections ( ! conc5trat$ decoction caus$ n]v\s twit*+s 9 frogs & kitt5s1 & if l>ge am\nts 7 us$ dea? foll[$ 9 f "o to two h\rs f p>alysis ( ! he>t4 ,! same symptoms 7 produc$ 9 frogs by ! injection ( an alcoholic extract ( ! residue left aft] ! evaporation to dryness ( ! decoction4 ,9 o!r words1 ,doctor ,day 0 able to produce a *ronic =m ( loco poison+ ) ! *>act]i/ic symptoms s (t5 describ$ save 9 ! occurr5ce ( di>rhea4 ,di>rhea is n usually not$ on ! range4 ,sayre _h already report$ an ulc]at$ condition ( ! inte/9es ( a loco$ c[ simil> to t describ$ by ,doctor ,day z occurr+ 9 cats4 ,doctor ,day urg$ t ! reason previ\s exp]im5t]s fail$ to produce symptoms 0 t !y _h us$ too small an am\nt ( ! plant & t by sy/ematic fe$+ to heal?y cats cases ( loco disease may be produc$4 ,/orke /ates t ,dr4 ,v4 ,c4 ,vaughan1 ( ! ,univ]sity ( ,mi*igan1 has s9ce fully corroborat$ ,dr4 ,day's views4#ajd ,9 h] exp]im5ts ,doctor ,day us$ ! leaves1 roots1 & /ems ( ! plants ga!r$ 9 ,septemb]4 ,%e believ$ t ! greate/ am\nt ( poison is pres5t 9 autumn & w9t]4 ,%e lat] und]took ! isolation ( ! active pr9ciple1 & proce$$ z foll[s3#aje ,! roots1 /ems1 & leaves 7 boil$ t5 h\rs1 /ra9$1 & ! decoction conc5trat$ to a sirup1 p\r$1 :ile hot1 into a hot flask1 cork$ & set away4 ,at ! end ( t5 days ! sirup _h sep>at$ into two lay]s--! upp] a blacki% liquid1 ! l[] a br[ni% s$im5t4 ,! liquid 0 p\r$ into a flask & cov]$ ) six times its volume ( v dilute alcohol1 #cj p] c5t 7! s$im5t also 0 wa%$ ) dilute alcohol1 to insure a complete removal ( ! liquid71 cork$1 & let /& ?ree days2 agitat$ occasionally1 !n filt]$1 & ! filtrate sl[ly evaporat$ 9 ! air1 :5 cry/als 7 =m$4 ,x 0 f\nd important n to hurry ! evaporation1 = :5 ?is took place too rapidly ! cry/als did n =m4 ,^! cry/als are microscopic 9 size1 blue-:ite 9 color1 & ( a v>iety ( =ms4 ,! mo/ *>act]i/ic are sl5d] & po9t$1 arrang$ 9 rosettes or gr\p$ 9 v>i\s ways4 ,!y are soluble 9 di/ill$ wat] & v dilute alcohol1 v sp>+ly soluble 9 /rong alcohol1 n soluble 9 *lor(orm or e!r4 ,! evaporat$ mass conta9+ ! cry/als1 :5 dissolv$ 9 di/ill$ wat]1 is slightly acid 9 reaction4 ,a small am\nt ( ?is f$ to a kitt5 produc$ ! tra9 ( *>act]i/ic toxic symptoms--sleep9ess1 loss ( appetite1 ret*+1 & di>rhea--t is produc$ by q l>ge am\nts ( ! decoction4 ,! cry/als ,sayre#ajf claims to h already se54 ,he says t !y gave no precipitate ) ,may]'s reag5t1 plat9um *lorid1 or ) ammonia1 b t b>ium *lorid & ammonium oxalate gave a precipitate1 & he believes t !y 7 9 reality an inorganic comb9ation ( calcium1 s t :ile ,doctor ,day may h obta9$ an extract :i* produc$ *>act]i/ic symptoms %e c]ta9ly has n isolat$ any pure active pr9ciple4 ,lat] %e admitt$ t x 0 n possible to make positive /atem5ts z to ! *emical "* ( ! active pr9ciple4#ajg ,9 #ahhd !re 0 a fatal outbreak ( a disord] 9 horses 9 portions ( ! ,miss\ri ,valley 9 ,i[a1 ,nebraska1 & ,dakota4 ,?is 0 almo/ uni=mly fatal 9 a few weeks or mon?s4 ,! animals lo/ /r5g? & became emaciat$1 al?\gh !y 7 kept 9 pa/ure :]e !re 0 abundant grass4 ,!re 0 m>k$ /upor1 ! animals fall+ asleep :ile eat+1 & !y w\ld rema9 /&+ = a :ole week1 sleep+ mu* ( ! "t1 ) ! head re/+ ^u "s object4 ,! po/-mortem exam9ation %[$ t 9 e in/ance !re 0 m>k$ hemorrhagic effusion into ! f\r? v5tricle1 ! liv] & sple5 7 abnormally d5se1 ! walls ( ! inte/9es 7 almo/ de/itute ( blood1 & ! /oma* enorm\sly di/5d$ ) undige/$ food4 ,! po/-mortem f9d & cl9ical symptoms sugge/$ to ,/alk]#ajh t ?is disord] 0 due to "s plant analog\s to ,a/ragalus mollissimus4 ,he f\nd abundant 9 ^! regions ,crotal>ia sagittalis1 or rattle-box1 "o ( ! s-call$ loco we$s1 & by ! adm9i/ration p] os to a "y horse ( an infusion ( #ae p\nds ( ! plant1 giv5 9 two days1 produc$ ! cl9ical symptoms & ! po/-mortem condition ( ! bra9 :i* he previ\sly obs]v$ on ! range4 ,p[] & ,cambi]#aji und]took ! *emical /udy & ! isolation ( ! active pr9ciple ( ?is plant1 toge!r ) t ( ,a/ragalus mollissimus4 ,!y f\nd t ! ,a/ragalus mollissimus if di/ill$ ) wat] yield$ a di/illate :i* possess$ a peculi> odor1 :i* !y ?\ght due to a trace ( volatile oil4 ,on di/ill+ ) alkali !y obta9$ ammonia & a trace ( trime?ylam9e4 ,9 ! case ( ,crotal>ia only ammonia 0 f\nd4#aaj ,!y argu$ t because trime?ylam9e 0 n obta9$ 9 ?is case *ol9e 0 n pres5t4 ,on di/ill+ ! ,a/ragalus mollissimus ) acidulat$ wat] 7,h#b,,s#d7 ! di/illate 0 f\nd to conta9 acetic acid--settl+ ! nature ( ! peculi> organic acid describ$ by ,k5n$y4 ,f ?is plant !y obta9$ a res9 or mixture ( res9\s bodies by extract+ ! plant ) alcohol1 & aft] conc5tration precipitat+ ) acid wat]4 ,^! res9s 9 doses ( f #b to #e gra9s fail$ to produce any symptoms 9 kitt5s4 ,an album9oid :i* 0 obta9$ by precipitat+ a conc5trat$ aque\s extract ( ,a/ragalus mollissimus by means ( alcohol likewise 0 f\nd to be inactive to a kitt5 9 doses correspond+ to #ej grams ( ! crude plant4 ,a globul9 :i* 0 isolat$ by precipitation f a #aj p] c5t sodium *lorid solution prov$ also to be inactive 9 doses ( #j4b gram4 ,!y !n extract$ #c kilograms ( ^! plants ) #a_/b p] c5t sulphuric acid1 & aft] evaporation to a ?ick gum ! mass 0 extract$ ) /rong alcohol1 ! alcoholic solution 0 evaporat$1 & ! alcoholic residue tak5 up 9 wat] & precipitat$ by neutral & basic lead acetates1 & aft] remov+ ! lead ) sulphuret$ hydrog5 ! filtrate gave precipitates ) v>i\s alkaloidal reag5ts4 ,! sirupy residue :i* !y obta9$ f ,a/ragalus mollissimus by decompos+ ! precipitate ) ,may]'s solution adm9i/]$ to kitt5s 9 doses ( #j4a gram produc$ m]ely fro?+ at ! m\? ) pr(use fl[ ( saliva1 b ! animals soon recov]$4 ,! pres5ce ( a l>ge am\nt ( calcium 0 %[n b n e/imat$ quantitatively4 ,p[] & ,cambi] summ$ up _! conclusions by /at+ t bo? ! ,a/ragalus & ! ,crotal>ia conta9 v small am\nts ( toxic alkaloids1 to :i* !y believe ! symptoms ( poison+ produc$ 7 due4 ,_! "w f a *emical /&po9t is excell5t1 b f a ph>macological po9t ( view seems to be defici5t2 9 fact1 ,p[] does n claim to be a ph>macologi/4 ,:at w\ld seem to be ! prop] c\rse w\ld h be5 to te/ = !mselves ! action ( ! plant on v>i\s animals &1 aft] decid+ :i* react$ mo/ *>act]i/ically1 te/1 aft] v>i\s precipitations1 bo? ! precipitates & filtrates on v>i\s animals to see :e!r ! orig9al symptoms & pa?ological lesions c\ld be produc$4 ,!y fail$1 h[ev]1 to te/ _! "m sub/ance4 ,x is well recogniz$ t plants gr[n "u v>y+ conditions & on diff]5t soils v>y 9 ! am\nt ( ! physiologically active pr9ciple !y conta94 ,9 ! case ( ,crotal>ia1 ,p[] & ,cambi] _h be=e !m ! exp]im5t ( ,/alk]1 9 :i* he reproduc$ ! disord] by fe$+ ! plant extract to horses1 yet !y claim$ t ! body :i* !y adm9i/]$ 0 ! active pr9ciple1 m]ely because x produc$ "s fro?+ at ! m\? & salivation 9 a kitt54 ,! p]c5tage ( active pr9ciple !y f\nd w\ld be too small to acc\nt = ! symptoms1 except 9 ! case ( a v active comp\nd4 ,c]ta9 ( ^! precipitates 7 also lat] exam9$ physiologically by ,o',br9e4#aaa ,he also f\nd ! res9 precipitat$ f an alcoholic extract ( ! plant & also ! alcoholic extract f #b4b p\nds ( ! dri$ ,a/ragalus mollissimus to be physiologically inactive4 ,oatman1#aab us+ ,p[] & ,cambi]'s me?od ) alfalfa 7,m$icago sativa71 obta9$ a noncry/all9e mass :i* :5 giv5 9 #j4a gram dose caus$ fro?+ at ! m\? 9 a kitt51 b no s]i\s symptoms4 ,?is #j4a gram repres5t$ ab\t #e p\nds ( p[d]$ leaves & tops ( ! plants4 ,s9ce ! appe>ance ( ,p[] & ,cambi]'s "w ,sayre has publi%$ v>i\s pap]s on ! loco we$s 9 ! ,transactions ( ! ,kansas ,academy ( ,sci5ces = #aijc-d1 vol4 #ai1 p4 #aid1 #aije2 #aija-b1 vol4 #ah1 p4 #ada2 ,sev5? ,bi5nial ,report ( ! ,/ate ,bo>d ( ,agriculture ( ,kansas1 vol4 #ab1 p4 #ig1 #ahia2 ,j\rnal ( ! ,kansas ,m$ical ,society1 vol4 #d1 pp4 #bbb & #bda1 #aijd1 etc4 ,he has contribut$ no?+ especially new1 b says t ! old !ory t an alkaloidal poison is secret$ 9 ! plant caus+ ! loco tr\ble has n be5 f\nd t5able1 b wi%es to be und]/ood t he does n discr$it ! gr\nd = ! op9ion t 9 "s my/]i\s way c]ta9 disord]s occur 9 cattle 9 connection ) :at is commonly call$ loco-we$4 ,he sugge/s t ?is connection might be some:at simil> to ! relation%ip betwe5 ! disord] caus$ by ov]-fe$+ half-/>v$ animals on clov] or alfalfa#aac & has _h ! plant analyz$ z to its nutritive value1 giv+ ! table 9 ! ,transactions ( ! ,kansas ,academy ( ,sci5ces1 vol4 #ai1 p4 #aid4 ,he makes ! sugge/ion t any injuri\s action ! plants may h might be due to ! f9e1 hair-l projections on ! plant :i* me*anically set up irritation4 ,?is supposition c be ?r[n out at once by ! exp]im5t ( ,day & o!rs1 :o induc$ symptoms 9 animals by extracts ( ! plant1 & by ! fact t o!r co>se plants d n act simil>ly4 ,?is f9e1 hair-l mat]ial 0 f\nd to con/itute ab\t #cc p] c5t ( ! plant on gr9d+4 ,b ,sayre himself does n seem to be positive z to any conclusion4 ,he1 l ,o',br9e & o!rs1 has obta9$ alkaloidal reactions f ! plant1 b /ates he has obta9$ simil> ones f alfalfa4#aad ,at "o "t he said3 ,i d n consid] loco directly or indirectly ! cause ( ! condition1 b am ( ! op9ion t :at is call$ loco$ is1 fir/1 conge/ion ( ! bra9 & sp9al m>r[ 7caus+ bl9dness & fir/ symptoms71 &1 second1 s(t5+ to a great] or less ext5t4#aae ,^! t]ms describ+ ! alleg$ symptoms ( locoism might occur 9 well recogniz$ diseases result+ f bra9 lesions1 :i* latt] occur 9 s-call$ =age poison+ & poison+ f f\l dr9k+ wat]1 etc4 ,we are n prep>$ to affirm or d5y t ! loco-we$ produces a tra9 ( symptoms *>act]i/ic ( ! plant4#aaf ,aga9 ,sayre /ates3 ,x seems n unreasonable to suppose t ! peculi> condition ( ! animals ( ! pla9s1 :5 !y gorge !mselves ) ?is highly nitrog5\s we$1 has some?+ to d ) ! disease4 ,a condition ( malnutrition may set 9 & give rise to ! rapid gr[? ( a toxic-produc+ micro-organism or an irritat+ pr9ciple4 ,?is pr9ciple may be capable ( cultivation & ( produc+ disease artificially4 ,be ?is z x may1 we feel w>rant$ 9 say+ t ! s-call$ poison is a developm5t )9 ! animal1 n a product preexi/+ 9 ! we$ itself4 ,sayre also sugge/s ! possibility ( ! plants produc+ hydro-cyanic acid1 :i*1 x is well kn[n1 occurs 9 sorghum4#aag ,9 ! ,j\rnal ( ! ,kansas ,m$ical ,society 7vol4 #d1 p4 #bdc71 he claims to h isolat$ a cry/all9e body1 b ?is he has n te/$ physiologically4 ,sayre especially des]ves cr$it = keep+ ! loco inve/igation alive1 & no d\bt 8 *ange 9 position is due to 8 lack ( facilities = ph>macological te/+4 ,c>l ,ru$i#aa f$ rabbits daily by a /oma* tube ) #aj c4c4 ( an extract 7un/at$ /r5g?7 ( ,a/ragalus mollissimus & record$ ! foll[+ results3 ,aft] only five injections "o ( ! rabbits di$1 & ! po/-mortem %[$ to a nicety ! conge/ion ( ! :ole tract ( ! v5a port & ! anmia ( ! bra94 ,i put six rabbits "u ! influ5ce ( loco1 & ! effect 0 m>k$1 b n rapid1 if n giv5 9 v conc5trat$ solutions4 ,! solutions 7 prep>$ diff]5tly1 & ea* ( ! rabbits _h its own prep>ation1 b ! effect 0 ne>ly ! same4 ,9 ! beg9n+ loco acts z a /imulant2 ! animals get lively1 hil>i\s1 runn+ ab\t2 clean+ !mselves1 etc4 ,?is la/s ab\t eight h\rs1 !n !y become v quiet1 sit 9 a corn] ( a box1 & "o c d ) !m pretty ne>ly :at "o likes2 !y d n move f ! place1 or j run into ano!r corn]1 to fall back into ! same complac5t rev]ie4 ,"o c leave ! door op5 & hamm] away at ! box1 b !y d n %[ any incl9ation to run away4 ,dur+ ! excitem5t1 h[ev]1 !y become fi]ce1 & ,i _h once ! opportunity to wat* "o ( ! drolle/ ?+s possible3 ,"o ( ! rabbits1 two h\rs aft] dos+ x1 got loose & ran "u a por*4 ,a heavy tomcat came ne> ?is hole1 & comm5c$ sniff+ ab\t2 ?is (f5d$ ! rabbit highly1 & x jump$ on ! neck ( ! cat1 bit x ?r\gh ! sk91 & ! cat ran scream+ away4 ,:5 ! animals are fir/ "u ! influ5ce ( mod]ate doses ( loco1 !y suff] greatly f hyp]/hesia ( ! cutane\s n]ves2 :5 "o t\*es !m ) a /ick :ile ly+ 9 a corn]1 )\t hurt+ !m1 "o sees ! platysma work+ away v =cibly1 & sometimes !y utt] s\nds ( pa94 ,accord+ to my exp]im5ts ! loco-we$ works sl[ly b surely2 z soon z ! anmia ( ! bra9 sets 91 ! animals act 9 e respect mad l2 "o h\r !y are excitable1 & !n aga9 dull & languid z c be4 ,! rabbits eat1 :5 well1 v quickly1 & :5ev] !y h opportunity2 n s ! loco$ rabbit2 he eats sl[ly = a m9ute or two1 !n he goes into a corn] & m$itates1 comes =w>d to nibble at a c>rot or a piece ( cabbage1 b he nev] eats gre$ily1 & does n /eal x f ! m\? ( 8 neighbor1 or only v exceptionally4 ,i obs]v$ ^! rabbits = t5 days2 !y did n die1 because ,i gave !m weak] solutions2 b !y all became v ill1 & z ,i _h to leave ! p>k ,i kill$ !m ) ! ne$le ins]t$ into ! m$ulla oblongata1 & made ! po/-mortem4 ,9 all ( ^! cases ,i f\nd great conge/ion 9 ! abdom51 & m>k$ anmia ( ! bra94 ,! conge/ion ( ! v5a port comm5ces c]ta9ly v e>ly1 b /ill ! fir/ symptoms are ! n]v\s symptoms1 fir/ z excitants1 !n depress+ or s$ative1 ) a m>k$ hyp]/hesia ( ! cutane\s n]ves4 ,ru$i made an attempt to isolate ! active pr9ciple & sep>at$ a base1 :i* he calls loco91 f an e!r %ak+4 ,?is base1 h[ev]1 he f\nd to be physiologically inactive1 b believes ! activity to be due to a body :i* he calls loco-acid1 :i* is pres5t 9 ! "m liquid aft] ! %ak+ ) e!r4 ,he1 h[ev]1 has n obta9$ ?is 9 any degree ( purity & gives no *emical data to sub/antiate ?is /atem5t save t ! fluid 0 acid4 ,exp]im5ts made at ! ,univ]sity ( ,p5nsylvania ) c]ta9 loco plants on cats1 dogs1 & rabbits prov$ negative4#aai ,o!r exp]im5ts on rabbits h be5 made by ,doctor ,lewis4 ,^! rabbits 7 f$ on ! leaves1 /em1 & :ole plant1 & also extracts ( "o ( ! loco plants 7presumably ,a/ragalus mollissimus7 = "o or two mon?s1 )\t produc+ any noticeable effect4#abj ,?is unc]ta9ty 9 ! results ( ! inve/igation z to ! cause ( ! loco disease turn$ ! att5tion ( obs]v]s into o!r l9es4 ,presid5t ,+]soll1#aba ( ! ,/ate ,agricultural ,college ( ,colorado1 9 8 autopsies on %eep 0 /ruck by ! pres5ce ( tapeworms 7,ta5ia expansa7 9 ! gall duct & small inte/9es4 ,he app>5tly tri$ to prove a relation%ip betwe5 ! tapeworms & ! loco$ condition by fe$+ ! extract ( a loco plant to %eep1 & ?us %[+ its h>mlessness4 ,he prep>$ a decoction f #bj p\nds ( loco plant 7! species 0 n /at$7 & boil$ ?is d[n f #ab gallons to #a qu>t4 ,?is conc5trat$ extract 0 f$ 9 ?ree days to a bottle-f$ lamb2 ?is lamb %[$ no symptoms1 al?\gh kept "u obs]vation = two weeks4 ,?is !ory ( ! causation ( loco by worms 0 also consid]$ by ,curtice1#abb & lat] br\ght =w>d by ,/eele#abc & ,m>%all4#abd ,?is idea is v sugge/ive :5 consid]$ 9 relation to ! etiology ( bo?riocephal\s anmia4#abe ,o!rs1 aga91 h claim$ t ! disease is due to a p>asite f\nd ^u ! loco plants1 b all specim5s exam9$ by entomologi/s prov$ to be h>mless4#abf ,lloyd1 f 8 /udy ( ! subject1 says3 ,f fir/ to la/ ,i h fail$ 9 obta9+ a *>act]i/ic proximate pr9ciple1 ei!r f ! fre% or dri$ plant4 ,! disease call$ loco 0 z murky z ! milk sickness s preval5t 9 ! new settlem5ts ( ,indiana & ,k5tucky 9 e>ly days1 &1 l ! numb]less h]bs t h be5 presum$ to produce t obscure peculi> disease1 milk sickness1 loco 0 unresponsive to my *emi/ry4#abg ,x may be safely said t if a specim5 ( ! plant 7 to be exam9$ 9 ! ord9>y mann] by a *emi/ :o _h no idea ( its importance he w\ld report t x did n conta9 a *>act]i/ic proximate con/itu5t4#abh ,c x be t an admixture ( loco & "s undet]m9$ plant or e>? infect$ ) bact]ia tak5 ) ! roots1 ea* innocu\s "u o!r conditions1 c by dige/ion toge!r 9 ! /oma* & inte/9es result 9 ! production ( a poison8#abi ,to sum up1 x seems to ! writ] t ! poison ( loco is a product1 & n an educt4#acj ,b ,lloyd adds1 9 speak+ ( ! reports ( v>i\s exp]ts & ran*m53 ,_! description conc]n+ its toxic action on animals agre$1 & x 0 folly to argue t s _m obs]v]s f s _m sections ( ! c\ntry c\ld be misl$4 ,!re mu/ be an undet]m9$ some?+ beh9d ! loco-we$4#aca ,9 #ahic ,o',br9e1 f ,colorado1 & ,mayo1 f ,kansas1 report$ on _! "w ) ! loco plants4 ,o',br9e fail$ to isolate any alkaloidal or o!r poison\s body1 & 8 fe$+ exp]im5ts on himself & on rabbits hav+ fail$1 he sums up 9 despair3 ,! m ,i exam9e ! loco "q1 ! m ,i am p]suad$ t we mu/ look = "s o!r cause besides ! loco-we$4#acb ,at ! end ( 8 report he gives "s a% analyses b fails to int]pret !m4 ,he also fails to give details z to ! me?od ( obta9+ & e/imat+ 8 a%4 ,o',br9e's a% analyses are z foll[s3 ,,key ,,to ,,a% ,,analysis3 ,a ,si,o#b4 ,b ,fe#b,o#c & ,al#b,o#c4 ,c ,ca,o4 ,d ,mg,o4 ,e ,k#b,o4 ,f ,na#b,o4 ,g ,h#b,,s#d ,h ,cl4 ,i ,p#b,o#e4 ,j ,,co#b ---------------------------------------- ---------------- ,plant4,total a%4 ,a ,b ,c ,d ,e ,f ,g ,h ,i ,j ---------------------------------------- ---------------- ,,am #ab4aecb4ggaf4bf #f4jec4aaac4cjc4bac4i #j4dgf4abaj4ee ,,al #ac4ebag4jhab4baad4bgb4fbag4bfe4gec4bbc4 hgc4cjag4cg ,,ac #ab4cf #g4hb #e4igab4ajc4eebc4cec4che4efi4j #d4fgbj4fb ---------------------------------------- ---------------- ,,key ,,to ,,plants3 ,,am ,a/ragalus mollissimus 7:ole plant7 ,,al ,aragallus lamb]ti 7:ole plant7 ,,z ,a/ragalus c>yoc>pus ,^! analyses are evid5tly incorrect1 z ,o',br9e e/imates a c>bon cont5t ( #d4ac p] c5t = ! fir/1 & = ! second #b4bb p] c5t1 %[+ incomplete combu/ion4 ,mayo#acc exp]im5t$ ) alcoholic & aque\s extracts ( dri$ ,a/ragalus mollissimus on gu9ea pigs1 ) negative results1 & 0 fir/ l$ to d5y a relation%ip betwe5 ! disease & ! plants4 ,lat]1 z a result ( ! po/-mortem f9d+s1 he 0 conv9c$ t 8 fir/ conclusion 0 wrong & t ! disease is c]ta9ly ! result ( animals fe$+ ^u ! loco-we$4 ,mayo says3 ,a c>eful survey ( ! exp]im5ts p]=m$ & obs]vations not$ leads me to ! op9ion t ! disease kn[n z loco is ! result ( malnutrition1 or a gradual />vation1 caus$ by ! animals eat+ ! plants kn[n z loco we$s1 ei!r ,a/ragalus mollissimus or ,aragallus lamb]ti4 ,if !re is a n>cotic pr9ciple 9 ! plant1 *emi/s h fail$ to f9d x & a fluid extract does n possess x1 & a ton ( ! plant eat5 by an animal ought to conta9 en\gh ( ! poison\s prop]ties to de/roy an animal4 ,kob]t#acd has also te/$ ! activity ( ,a/ragalus mollissimus & says1 ,i* f& ,a/ragalus mollissimus ziemli* unwirksam4 ,doctor ,mc,eackran#ace f$ dri$ ,a/ragalus mollissimus & ,aragallus lamb]ti mix$ ) fe$ to a /abl$ animal = two mon?s )\t result4 7,animal n /at$74#acf ,simil> negative exp]im5ts are report$ f ! ,/ate ( ,wa%+ton1 b ! am\nts us$ 7 too small to =m any conclusions4#acg ,mr4 ,v4 ,k4 ,*esnut#ach has busi$ himself ) ! loco problem1 b ma9ly 9 an executive capacity1 8 own ef=ts be+ direct$ to ! /udy ( ! relation ( ! loco plants to ! disease on ! range4 ,he has done no laboratory "w4 ,*esnut & ,wilcox made num]\s autopsies on %eep & exp]im5ts on animals4 ,!y claim$ t an extract ( ,aragallus spicatus produc$ "s slight n>cotic action 9 rabbits4 ,_! pa?ological exam9ations fail$ to %[ any *>act]i/ic lesion1 b !y /ate t ! c]ebral membranes 7 9 all cases slightly conge/$4 ,!y d5y any causative relation%ip to ! pres5ce ( worms or ) fe$+ ^u alkalis4 ,!y believe t %eep are m likely to become loco$ if n salt$ regul>ly4 ,*esnut describes "o case 9 :i* a lamb became loco$ by nurs+ f a loco$ "m4 ,9 #aija ,reid ,hunt1 at t "t a special ag5t ( ! ,unit$ ,/ates ,dep>tm5t ( ,agriculture1 /udi$ ! loco "q 9 ,montana1 work+ ma9ly ) ,aragallus spicatus4 ,he moi/5$ ! gr\nd-up plant ) #ic p] c5t e?yl alcohol & !n p]colat$ x until exhau/$4 ,?is extract 0 evaporat$ & tak5 up ) wat] s t #a c4c4 ( ! solution correspond$ to #aj grams ( ! plant4 ,?is 0 f$ to an active "y rabbit weigh+ #dij grams1 #f c4c4 be+ f$ by ! m\? & foll[$ 9 ab\t an h\r by #aj c4c4 m1 & two h\rs aft] ?is by #ae c4c4 ,?is rabbit %[$ no symptoms dur+ ! foll[+ day4 ,! next day x 0 v dull & !re 0 m>k$ muscul> weakness1 z ! rabbit's legs 7 spread wide ap>t & 8 nose re/$ on ! gr\nd4 ,lat] respiration became v sl[ & ! pupils 7 dilat$4 ,! p>alytic symptoms increas$ & f9ally1 aft] a convulsive movem5t1 ! animal di$1 ?irty-six h\rs aft] ! fir/ fe$+4 ,hunt m]ely /ates ( ! po/-mortem exam9ation t ! /oma* 0 well fill$ & t ! walls seem normal4 ,hunt tri$ to isolate an active pr9ciple by ! ,drag5dorff me?od1 b fail$ to obta9 any physiologically active %ak+s4 ,he tri$ hypod]mic injections ( #hj p] c5t alcohol extractions ( ! fre% gre5 plant1 & aft] ! injection ( an extract correspond+ to #fj grams ( ! fre% plant !re 0 no effect produc$4 ,he tri$ to induce symptoms by fe$+ ! plant itself to rabbits1 b 0 unsuccessful1 z ! rabbits refus$ to eat ! plant4 ,he 0 n able to induce symptoms ) ! extracts ( ! dri$ plant4#aci ,m>%all#adj /udi$ ! loco "q ) reg>d to %eep & practically d5ies ! exi/5ce ( a loco$ condition due to eat+ ! loco plants1 b believes ! condition due to bad fe$+1 p>asitism1 etc4 ,he lays great /ress ^u ! pres5ce ( worms1 b fails to see t !y may be m]ely a second>y infection sup]impos$ ^u an already morbid condition produc$ by eat+ ! plants4 ,o!rs h claim$ t ! cause is an insect liv+ ^u ! loco plants4 ,o!rs1 aga91 h sugge/$ an analogy ) trypanosome disord]s4 ,*esnut has held ! view t _m ( ! cases ( s-call$ loco$ %eep 7 really due to p>asites1 b t !re 0 a true loco$ condition due to eat+ ! loco we$s4 ,! lack ( agreem5t 9 ! results ( ! inve/igators has caus$ _m to d\bt any positive relation betwe5 ! plant & ! disease1 & ev5 z late z #aijd ,payne#ada practically says ^! diseases are due to lack ( nutrition & n to ! loco plant4 ,! matt] has be5 summ$ up 9 a rec5t "w z foll[s3 ,?\gh _m *emi/s h s\ght = ! con/itu5ts1 none h be5 able to locate ! active prop]ties1 ! trace ( alkaloids1 res9s1 volatile & fix$ oils hav+ ea* 9 turn be5 f\nd de/itute ( x4 ,yet ! poison\s prop]ties are fully e/abli%$ by field obs]vations4 ,! de/ructiv5ess ( ^! plants to /ock is s great z to h probably caus$ upw>d ( a million doll>s loss 9 ! aggregate1 & l>ge b\nties h be5 (f]$ by ,/ate gov]nm5ts = an effective me?od ( avoid+ su* losses4 ,x is consid]$ v probable t ! poison\s con/itu5t is album9oidal4#adb 99 99 99 99 99 ,,footnotes3 #hc ,/orke1 ,b4 ,f4 ,! ,loco ,we$4 ,m$4 ,curr5t1 vol4 #h1 p4 #aee4 #ahib4--,kellogg1 ,a4 ,cali=nia & ,colorado ,loco ,poisons4 ,cal4 ,acad4 ,sci4 ,proc4 = #ahge1 vol4 #f1 p4 #c4 #ahgf4 ,,note4--,! v e>ly reports ( ^! loco plants 7 purely botanical4 ,see ,torrey1 ,j41 ,botany1 9 ,report on ! ,unit$ ,/ates & ,mexican ,b\nd>y ,survey1 by ,w4 ,h4 ,emory1 vol4 #b1 p4 #ef1 #ahei2 also ,botanical ,regi/]1 ,london1 vol4 #ac1 pl4 #ajed1 #ahbg4 #hd ,vasey1 ,g4 ,plants ,poison\s to ,cattle 9 ,cali=nia4 ,rept4 ( ,commission] ( ,agriculture = #ahgd1 p4 #aei4 #ahge4 #he ,vasey1 ,g4 ,botanical ,notes4 ,mon?ly ,reports ( ,dept4 ,agriculture = #ahgc1 p4 #ejc4 #ahgd4 #hf ,vasey1 ,g4 ,botanical ,notes4 ,mon?ly ,reports ( ,dept4 ,agriculture = #ahgd1 p4 #eac4 #ahge4 #hg ,brew]1 ,w4 ,h41 & ,watson1 ,s4 ,geological ,survey ( ,cali=nia1 ,botany1 vol4 #a1 p4 #aee4 #ahgf4 #hh ,ro?rock1 ,j4 ,t4 ,notes on ,economic ,botany1 9 ,g4 ,m4 ,:eel]'s ,report ^u ,u4 ,s4 ,geographical ,surveys ,we/ ( ! ,"o ,hundr$? ,m]idian1 vol4 #f1 p4 #dc4 #ahgh4 #hi ,kellogg1 ,a4 ,cali=nia & ,colorado ,loco ,poisons4 ,cal4 ,academy ( ,sci5ces1 ,proc41 #ahge1 vol4 #f1 p4 #c4 #ahgf4 #ij ,ro?rock1 ,j4 ,t4 ,poison\s ,prop]ties ( ! ,legum9os4 ,acad4 ( ,nat4 ,sci41 ,phila41 ,proc41 vol4 #bi1 p4 #bgd4 #ahgg4 #ia ,prescott1 ,a4 ,b4 ,laboratory ,notes--,a ,p>tial ,analysis ( ! ,oxytropis ,lamb]ti4 ,am]4 ,j\rn4 ,ph>m41 vol4 #ej1 p4 #efd4 #ahgh4 #ib ,rept4 ( ,commission] ( ,agriculture = #ahgh1 p4 #acd4 #ahgi4 #ic ,rept4 ( ,commission] ( ,agriculture = #ahgi1 pp4 #hi1 #ij4 #ahhj4 #id ,rept4 ( ,commission] ( ,agriculture = #ahhf1 p4 #ge4 #ahhg4 ,rept4 ( ,commission] ( ,agriculture = #ahhd1 p4 #abc4 #ahhd4 #ie ,ro?rock1 ,j4 ,t4 ,notes on ,economic ,botany1 9 ,g4 ,m4 ,:eel]'s ,report ^u ,u4 ,s4 ,geographical ,surveys ,we/ ( ! ,"o ,hundr$? ,m]idian1 vol4 #f1 p4 #dc4 #ahgh4 #if ,gibbons1 ,h4 ,poison\s ,effects ( ,crotal>ia--,vulgo ,rattle ,we$1 ,loco ,we$4 ,pacific ,m$4 & ,surg4 ,j\rn41 vol4 #ba1 p4 #dif4 #ahgh-gi4 #ig ,ott1 ,i4 ,physiological ,action ( ,a/ragalus ,mollissimus4 ,new ,rem$ies1 vol4 #aa1 p4 #bbg4 #ahhb4 #ih ,hill1 ,j4 ,r4 ,note on a ,species ( ,a/ragalus f ,cyprus4 ,ph>m4 ,j\rn4 & ,trans41 #c s41 vol4 #ah1 p4 #gab4 #ahhg-hh4 #ii ,sayre1 ,l4 ,e4 ,loco-,we$4 ,proc4 ,am]4 ,ph>m4 ,assoc41 vol4 #cf1 p4 #aab4 #ahhh4 #ajj ,sayre1 ,l4 ,e4 ,loco ,we$4 ,am]4 ,vet4 ,rev41 vol4 #aa1 p4 #eef4 #ahhg4 #aja ,k5n$y1 ,j4 ,loco ,we$ 7,crazy ,we$74 ,ph>m4 ,rec41 vol4 #h1 p4 #aig4 #ahhh4 #ajb ,day1 ,m4 ,g4 ,exp]im5tal ,demon/rations ( ! ,toxicity ( ! ,loco ,we$4 ,n4 ,y4 ,m$4 ,j\rn41 vol4 #di1 p4 #bcg4 #ahhi4 #ajc ,presumably a #aj p] c5t decoction1 ,u4 ,s4 ,p4 #ajd ,/orke1 ,r4 ,f4 ,! ,loco ,we$4 ,m$4 ,curr5t1 vol4 #h1 p4 #aeg4 #ahib4 #aje ,day1 ,m4 ,g4 ,! ,sep>ation ( ! ,poison ( ! ,loco ,we$4 ,n4 ,y4 ,m$4 ,j\rn41 vol4 #ej1 p4 #fjd4 #ahhi4 #ajf ,sayre1 ,l4 ,e4 ,active ,pr9ciple ( ,loco ,we$4 ,notes on ,new ,rem$ies1 vol4 #b1 ,no4 #ab1 p4 #a4 #ajg ,day1 ,m4 ,g4 ,loco ,we$1 9 ,f4 ,p4 ,fo/]'s ,ref]5ce-,book ( ,practical ,!rapeutics1 vol4 #a1 p4 #ehh4 #ahif4 #ajh ,/alk]1 ,m4 #a/ ,ann4 ,rept4 ,/ate ,vet4 ,surg4 ,i[a1 p4 #af4 #ahhe4 #aji ,p[]1 ,f4 ,b41 & ,cambi]1 ,j4 ,*emical ,exam9ation ( ,"s ,loco-,we$s4 ,ph>m4 ,runds*au1 vol4 #i1 p4 #h4 #ahia4--,p[]1 ,f4 ,b4 ,notes on ! ,s-call$ ,loco ,we$s4 ,ph>m4 ,runds*au1 vol4 #g1 p4 #acd1 #ahhi4--,see also ,h(fmann1 ,f41 ,loco-,we$s1 9 ,ph>m4 ,runds*au1 vol4 #g1 p4 #afh4 #ahhi4 #aaj ,k5n$y1 ,j4 ,ph>m4 ,rec41 vol4 #h1 p4 #aig4 #ahhh4 ,k5n$y also obta9$ ammonia f ,a/ragalus mollissimus4 #aaa ,o',br9e1 ,d4 ,progress ,bullet9 on ! ,loco & ,l>kspur4 ,colo4 ,/ate ,agric4 ,coll4 ,bul4 #be1 p4 #ah4 #ahic4 #aab ,oatman1 ,h4 ,c4 ,! ,poison\s ,pr9ciple ( ,loco ,we$4 ,notes on ,new ,rem$ies1 vol4 #d1 p4 #ad4 #ahia-ib4 #aac ,sayre1 ,l4 ,e4 ,loco ,we$4 ,kans4 ,acad4 ,sci4 ,trans41 vol4 #ah1 p4 #ada4 #aijc4 #aad ,sayre1 ,l4 ,e4 ,loco ,we$s4 #g? ,bi5n4 ,rept4 ,kans4 ,/ate ,bo>d ,agric4 = #ahhi-ij1 vol4 #ab1 pt4 #b1 p4 #ii4 #ahia4 #aae ,sayre1 ,l4 ,e4 ,fur!r ,report on ,loco ,we$s4 ,notes on ,new ,rem$ies1 vol4 #d1 p4 #hj4 #ahia-ib4 #aaf ,sayre1 ,l4 ,e4 ,! ,loco ,disease4 ,j\rn4 ,kans4 ,m$4 ,soc41 vol4 #d1 pp4 #bda-bdc4 #aijd4--,:at is ,insanity 9 ,l[] ,animals8 ,j\rn4 ,kans4 ,m$4 ,soc41 vol4 #d1 p4 #bbb4 #aijd4 #aag ,sayre1 ,l4 ,e4 ,loco ,we$4 ,kans4 ,acad4 ,sci4 ,trans41 vol4 #ah1 p4 #add4 #aijc4 #aah ,ru$i1 ,c4 ,loco ,we$ 7,a/ragalus ,mollissimus73 ,a ,toxico-,*emical ,/udy4 ,trans4 ,colo4 ,/ate ,m$4 ,soc41 p4 #dah4 #ahie4--;,also ,treatm5t ( ,animals ,poison$ by ,loco ,we$ 7unpubli%$ article74 #aai ,! ,loco ,disease4 ,!rap4 ,gaz41 vol4 #ab1 p4 #cj4 #ahhh4 #abj ,sayre1 ,l4 ,e4 ,loco ,we$4 ,kans4 ,acad4 ,sci4 ,trans41 vol4 #ah1 p4 #adb4 #aijc4 #aba ,sayre1 ,l4 ,e4 ,loco ,we$s4 #g? ,bi54 ,rept4 ,kansas ,/ate ,bo>d ,agric4 = #ahhi-ahij1 pt4 #b1 p4 #ih4 #ahia4 #abb ,curtice1 ,c4 ,tape-,worm ,disease ( ,%eep ( ! ,we/]n ,pla9s4 ,bur4 ,animal ,indu/ry1 #d? & #e? ,ann4 ,rept41 p4 #afg4 #ahhi4 #abc ,/eele1 ,c4 ,d4 ,new ,!ory ab\t ,loco4 ,f>m & ,ran*1 vol4 #bj1 ,no4 #ce1 p4 #a4 #aija4 #abd ,m>%all1 ,h4 ,t4 ,loco ,we$ ,disease ( ,%eep4 ,johns ,hopk9s ,hospital ,bul41 vol4 #ae1 p4 #aha4 #aijd4--;,data z to ^! p>asites ( %eep may be f\nd 9 ,curtice1 ,c41 ,! ,animal ,p>asites ( ,%eep1 ,bur4 ,animal ,indu/ry1 ,rept41 #ahij4 #abe ,fau/1 ,e4 ,s41 & ,tallqui/1 ,t4 ,w4 ,ueb] d4 ,ursa*5 d] ,bo?riocephalus-anmie4 ,ar*4 f4 ,exp4 ,pa?41 vol4 #eg1 p4 #cfg4 #aijg4 #abf ,wal%ia ,amorphella & ! ,loco ,we$4 ,insect ,life1 vol4 #b1 p4 #ej4 #ahhi-ij4 ,sn[1 ,f4 ,h4 ,loco-,we$4 ,sci5ce1 vol4 #i1 p4 #ib4 #ahhg4 #abg ,lloyd1 ,j4 ,u4 ,loco1 or ,crazy ,we$4 ,eclectic ,m$4 ,j\rn41 vol4 #ec1 p4 #dhb4 #ahic4 #abh ,lloyd1 ,j4 ,u41 l4 c41 p4 #dhc4 #abi ,lloyd1 ,j4 ,u41 l4 c41 p4 #dhd4 ,,note4--,eccles _h previ\sly ann\nc$ a some:at simil> idea4 ,sayre1 ,l4 ,e4 ,loco ,we$4 ,proc4 ,am]4 ,ph>m4 ,assoc41 vol4 #cf1 p4 #aae4 #ahhi4 #acj ,lloyd1 ,j4 ,u41 l4 c41 p4 #dhf4 #aca ,lloyd1 ,j4 ,u41 l4 c41 p4 #dhc4 #acb ,o',br9e1 ,d4 ,progress ,bullet9 on ! ,loco & ,l>kspur4 ,colo4 ,/ate ,agric4 ,coll4 ,bul4 #be1 p4 #ag4 #ahic4 #acc ,mayo1 ,n4 ,s4 ,"s ,obs]vations on ,loco4 ,kans4 ,/ate ,agric4 ,coll4 ,bul4 #ce1 p4 #aaf4 #ahic4 #acd ,kob]t1 ,r4 ,lehrb4 d4 ,intoxikation51 p4 #fae4 #ahic4 #ace ,o',br9e1 ,d4 ,progress ,bullet9 on ,loco & ,l>kspur4 ,colo4 ,/ate ,agric4 ,coll4 ,bul4 #be1 p4 #ac4 #ahic4 #acf ,aft] ! manuscript ( ?is bullet9 0 s5t to ! pr9t] x 0 le>n$ ?r\gh ,pr(essor ,c>p5t] t ! animal 0 a horse4 #acg ,nelson1 ,s4 ,b4 ,fe$+ ,wild ,plants to ,%eep4 ,bur4 ,animal ,indu/ry1 ,bul4 #bb1 p4 #ab4 #ahih4 #ach ,*esnut1 ,v4 ,k41 & ,wilcox1 ,e4 ,v4 ,/ock-,poison+ ,plants ( ,montana4 ,u4 ,s4 ,dept4 ,agric41 ,div4 ,bot41 ,bul4 #bf1 p4 #ie4 #aija4--,wilcox1 ,e4 ,v4 ,plant ,poison+ ( ,/ock 9 ,montana4 ,bur4 ,animal ,indu/ry1 #ag? ,ann4 ,rept41 p4 #aaa4 #aijj4 ,,note4--,! writ] wi%es to ackn[l$ge ! great lit]>y help ,mr4 ,*esnut's c>d catalogue has be5 to him 9 ! prep>ation ( ?is pap]4 #aci ,unpubli%$ report4 #adj ,m>%all1 ,h4 ,t4 ,loco ,we$ ,disease ( ,%eep4 ,johns ,hopk9s ,hospital ,bul41 vol4 #ae1 p4 #ahb4 #aijd4 #ada ,payne1 ,j4 ,e4 ,cattle ,rais+ on ! ,pla9s4 ,colo4 ,agric4 ,expt4 ,/a4 ,bul4 #hg1 p4 #af4 #aijd4 #adb ,national ,/&>d ,disp5satory1 p4 #hfh4 #aije4 ,,note4--,! field exp]im5ts ( ,h>d+ & ,tudor are r conclusive z to ! relation ( ^! plants to ?is disord]4 ,sayre1 ,l4 ,e41 ,loco ,we$1 ,am]4 ,vet4 ,rev41 vol4 #aa1 pp4 #eec-eed1 #ahhg--;,blank9%ip1 ,j4 ,w41 ,loco & ,"s ,o!r ,poison\s ,plants 9 ,montana1 ,mont4 ,agric4 ,exp]4 ,/a4 ,bul4 #de1 pp4 #hc-hd1 #aijc--,loco ,disease1 ,!rap4 ,gaz41 vol4 #ab1 p4 #cj4 #ahih4 ,,notes ,,on ,,v>i\s ,,memb]s ,,( ,,! ,,loco-,,we$ ,,family4 ,a/ragalus c>yoc>pus is at times eat5 9 "s ( ! ,we/]n ,/ates1 b is claim$ by "s at c]ta9 /ages ( its gr[? to conta9 a poison\s pr9ciple4 ,frank=t]1#adc f exp]im5ts on himself1 h[ev]1 d5ies ?is4 ,a/ragalus glycophyllus has be5 us$ z a diuretic & ,a/ragalus exscapus 9 ! treatm5t ( syphilis4#add ,! se$ ( ,a4 boeticus1 plant$ 9 ,g]many & ,engl&1 are f\nd to be ! v be/ sub/itute = c(fee yet tri$1 & s us$--roa/$1 p>*$1 & mix$ ) c(fee4#ade ,a/ragalus nuttallianus1 accord+ to ,smi?1#adf is a highly nutriti\s =age plant 9 spr+4 ,a/ragalus crassic>pus has be5 prophesi$ by him to be a valuable addition to e>ly spr+ soil+ crops4 ,a/ragalus adsurg5s 7nitidus7 & "o or two o!r species ( ,a/ragalus are /ill us$ 9 ,*9ese m$ic9e4#adg ,! ,indians ( ! ,s\?we/ are famili> ) c]ta9 loco plants4#adh ,! ,tewans ( ,hano are said to eat ! root ( ,aragallus lamb]ti1 & ,a/ragalus mollissimus is appli$ locally = heada*es by "s ( ! ,arizona ,indians4 ,"o ( ^! species is us$ z a flavor+ mat]ial by ! ,coahuillas & is mix$ ) o!r plants z spices4#adi ,a/ragalus k5trophyta _h a reputation among ! ,navajos = ! treatm5t ( rabies4#aej ,! use ( c]ta9 loco plants--,a/ragalus mollissimus--has be5 advocat$ on !oretical gr\nds 9 ! treatm5t ( c]ta9 =ms ( insanity1 b )\t favorable results4#aea ,9 ,p]u & ,*ile ,a/ragalus g>bancillo1 ,a4 unifultus1 & ,a4 o*roleucus h be5 consid]$ injuri\s to animals4#aeb ,a/ragalus glyciphyllus & ,a4 alp9us h be5 us$ 9 ,europe z food = /ock4#aec ,details z to ! use ( o!r ,a/ragali c be f\nd 9 ,plan*on1 ,g41 ,sur les ,a/ragales1 9 ,j\rnal de ,ph>macie et de ,*imie1 #e? s]ies1 vol #bd1 p4 #dgc1 #ahia2 #e? s]ies1 vol4 #be1 pp4 #afi1 #bcc1 #ahib4 99 99 99 99 99 ,,footnotes3 #adc ,frank=t]1 ,g4 ,b4 ,a ,*emical ,/udy ( ,a/ragalus ,c>yoc>pus4 ,am]4 ,j\rn4 ,ph>m41 vol4 #gb1 p4 #cbj4 #aijj4 #add ,mais*1 ,j4 ,m4 ,poison\s ,species ( ,a/ragalus4 ,am]4 ,j\rn4 ,ph>m41 vol4 #ea1 p4 #bdj4 #ahgi4--;,fleurot4 ,*imiques et ,ph>maceutiques sur la ,rac9es d',a/ragale sans ,tiges4 ,j\rn4 de ,*im4 ,m$41 vol4 #aj1 p4 #fef4 #ahcd4 #ade ,por*]1 ,f4 ,p4 ,res\rces ( ! ,s\!rn ,fields & ,=e/s1 p4 #bjd4 #ahfi4 #adf ,smi?1 ,j4 ,g4 ,fodd] & ,=age ,plants4 ,u4 ,s4 ,dept4 ,agric41 ,div4 ,agro/41 ,bul4 #b 7rev4 ed471 p4 #ab4 #aijj4 #adg ,holmes1 ,e4 ,m4 ,notes on ,*9ese ,drugs4 ,ph>m4 ,j\rn4 & ,trans41 vol4 #ba1 #c s41 p4 #aadi4 #ahia4 #adh ,h\gh1 ,w4 ,environm5tal ,int]relations 9 ,arizona4 ,am]4 ,an?ropologi/1 vol4 #aa1 pp4 #adc1 #adg4 #ahih4 #adi ,b>r[s1 ,d4 ,p4 ,e?no-,botany ( ! ,coahuilla ,indians ( ,s\!rn ,cali=nia1 p4 #fg4 #aijj4 #aej ,mat!ws1 ,w4 ,navajo ,names = ,plants4 ,am]4 ,nat41 vol4 #bj1 p4 #ggb4 #ahhf4 #aea ,giv5s1 ,a4 ,j4 ,loco or ,crazy ,we$4 ,m$4 ,c5tury1 vol4 #a4 p4 #ba4 #ahic4--;,comp>e ,hurd1 ,h4 ,m4 ,am]4 ,j\rn4 ,insanity1 vol4 #db1 p4 #agh4 #ahhe-hf4 #aeb ,ros5?al1 ,d4 ,a4 ,synopsis ,plant>um ,diaphoric>um1 ,erlang51 #ahfa1 p4 #ajjd4 ,gre%(f1 ,m4 ,bes*rijv+ d4 ,giftige en ,b$welmeude ,plant5 bij de ,vis*vang/ 9 ,gebrulk1 p4 #ea4 #aijj4 #aec ,pott1 ,e4 ,h&b4 d4 ti]is*4 ,ernhrung1 vol4 #b1 p4 #aac4 #aijg4 ,,laboratory ,,exp]im5ts--,,physiological4 ,! fir/ po9t 9 our inve/igations 0 to det]m9e :e!r ! plant ex]t$ any poison\s action & to f9d "s animal :i* respond$ regul>ly to x2 !n to asc]ta9 if ! lack ( results ( previ\s inve/igators 0 n due to insuffici5t doses1 & lat] to see if by fe$+ small] am\nts at repeat$ int]vals symptoms comp>able to ^? describ$ z occurr+ on ! range c\ld n be produc$4 ,! animal f9ally select$ 0 ! rabbit4 ,,exp]im5ts ,,on ,,rabbits4 ,,acute ,,cases4 ,exp]im5t ,no4 #a4--,on ,septemb] #h1 #aije1 an aque\s extract ( #ccc grams ( fre% ,a/ragalus mollissimus1 made 9 ,hugo1 ,colo41 & %ipp$ pres]v$ 9 *lor(orm1#aed kill$ a rabbit weigh+ #a1faf grams 9 "o h\r & ?irty-five m9utes1 :ile an extract correspond+ to #afg grams m]ely caus$ dr[s9ess & loss ( appetite 9 a rabbit weigh+ #gfe grams4 ,exp]im5t ,no4 #b4--,on ,novemb] #bi1 #aije1 a rabbit weigh+ #a1afb4c grams 0 f$ ) a conc5trat$ aque\s extract ( #ejj grams ( fre% ,a/ragalus mollissimus1 :i* _h be5 %ipp$ f ,hugo1 ,colo41 pres]v$ 9 *lor(orm 9 seal$ vessels4 ,?is animal di$ 9 "o h\r & t5 m9utes4 ,! symptoms consi/$ 9 dullness1 rapid respiration1 & signs ( pa94 ,at autopsy ! /oma* & upp] "p ( ! small inte/9es %[$ hemorrhagic ec*ymoses1 ) dilation ( ! dural vessels ( ! bra9 & cord1 ) a clot ov] a portion ( ! sp9al cord4 ,exp]im5t ,no4 #c4--,on ,febru>y #ac1 #aijf1 a rabbit weigh+ #iib grams 0 f$ ) a conc5trat$ aque\s extract ( #ejj grams ( ! fre% ,a/ragalus mollissimus1 collect$ 9 ,septemb] & pres]v$ 9 *lor(orm wat]4 ,be=e fe$+1 ! rabbit's e>s 7 w>m & ! rabbit /ruggl$ :5 any attempt 0 made to turn him on 8 back4 ,! temp]ature at #aj4ej a4m41 ! "t ( fe$+1 0 #ajc4e;,f42 at #aa4ae a4m41 #ajb4e;,f4 ,at #aa4cj a4m4 ! rabbit 0 brea?+ v rapidly & w\ld /ay on 8 back = "s "t if plac$ s4 ,! temp]ature at ?is "t 0 #ajb4f;,f4 ,bo? pupils1 ! "o expos$ to ! light & ! "o protect$1 7 contract$4 ,at #ab4jb p4m4 convulsive movem5ts ( ! legs appe>$4 ,! rabbit made "o leap1 ! temp]ature rose to #ajc4f;,f41 & aft] a few convulsive movem5ts ( ! limbs ! anus relax$ & a small /ool appe>$1 ! pupils dilat$1 & ! animal di$ at #ab4jf p4m4 ,exp]im5t ,no4 #d4--,! fe$+ ( ! extract ( #dfd grams induc$ a fall 9 temp]ature ( #b4d;,f4 9 ?ree h\rs1 & ! rabbit di$ sev]al h\rs lat] 7at night74 ,exp]im5t ,no4 #e4--,m>* #b1 #aijf1 a rabbit weigh+ #ibh grams 0 f$ ) a conc5trat$ extract ( #ejj grams ( ! fre% se$s & pods ( ,a/ragalus mollissimus1 made 9 ,septemb]1 #aije1 & pres]v$ ) *lor(orm wat]4 ,?is animal di$ 9 "o h\r & sev5 m9utes4 ,! animal %[$ ! usual po/-mortem conditions4 ,x 0 ?us f\nd t ! aque\s extract ( #ejj grams ( ! fre% ,a/ragalus mollissimus w\ld cause dea? 9 ab\t "o h\r 9 rabbits weigh+ ab\t #b p\nds 7#ijg grams71 ^! rabbits %[+ con/ant cl9ical symptoms--ur9ation1 p>alysis1 m or less convulsive muscul> twit*+s1 (t5 t]m9at+ 9 g5]al convulsions1 dr[s9ess1 & /upor1 ) m or less ane/hesia4 ,! pupils at ! "t ( dea? 7 (t5 unequal4 ,at fir/ !re 0 usually a slight rise 9 temp]ature1 b ?is 0 soon succe$$ by a fall4 ,(t5 !re 7 s(t /ools4 ,! po/-mortem lesions 9 ^! cases 7 m>k$ conge/ion1 ) hemorrhages 9 ! /oma* walls & a secretion ( ?ick mucus4 ,! portions ( ! /oma* walls mo/ affect$ 7 ! dep5d5t portions ne> ! c>diac end4 ,! inte/9es %[$ dilatation ( ! blood vessels4 ,! mes5t]ic vessels & also ! vessels 9 ! c]ebral portions ( ! dura 7 m>k$ly dilat$2 9 "s cases !re 7 clots1 especially at ! po/]ior portion ( ! bra91 betwe5 ! c]ebrum & ! c]ebellum4 ,at times !re 7 clots ov] ! dorsal portion ( ! cord4 ,on cutt+ into ! bra9 ! bra9 sub/ance itself did n appe> to be conge/$4 ,! cord seem$ ab\t normal1 b ! vessels ( its membranes 7 well m>k$4 ,! o!r organs %[$ no?+ *>act]i/ic macroscopically4 ,^! exp]im5ts 7 repeat$ _m times & f\nd to be con/ant4 ,^! acute symptoms 7 likewise produc$ by an extract ( #ejj grams ( ! fre% ,aragallus lamb]ti f ,arizona pres]v$ 9 *lor(orm wat] 7rabbit weigh+ #a1iih grams74 ,an aque\s extract ( #aej grams ( ! dri$ ,a/ragalus mollissimus#aee f ,imp]ial1 ,nebr4 7#aijf71 caus$ dea? 9 "o h\r & fifty-eight m9utes 9 a rabbit weigh+ #a1ecj grams1 & an extract ( #ajj grams kill$ 9 "o h\r & tw5ty-two m9utes a rabbit weigh+ #gcf grams4 ,an aque\s extract ( #ajj grams ( ! dri$ ,a/ragalus bigel[ii induc$ dea? 9 "o h\r & ?irty-eight m9utes1 ! rabbit weigh+ #a1ejb grams4 ,an aque\s extract ( #aej grams ( ,a/ragalus nitidus collect$ at ,woodl& ,p>k1 ,colo41 9 #aijf induc$ dea? 9 ?ree h\rs & five m9utes1 ! rabbit weigh+ #a1fgb grams4 ,an aque\s extract ( #bjj grams ( ! dri$ ,a/ragalus bisulcatus caus$ dea? aft] sev]al h\rs 7at night71 ! rabbit weigh+ #b1dbc grams4 ,9 c]ta9 cases ?is production ( acute symptoms 0 n entirely a "q ( salt action1 z 0 %[n by c]ta9 o!r exp]im5ts4 ,9 o!r cases salt action seems to be ! important factor1 s t ! production ( ^! acute symptoms c n always be consid]$ *>act]i/ic4 99 99 99 99 99 ,,footnotes3 #aed ,9 all cases 9 :i* ! plants 7 pres]v$ ) *lor(orm seal$ vessels 7 us$ = %ipp+4 ,! *lor(orm 0 c>efully evaporat$ (f 9 vacuo be=e fe$+ ! extract1 ! evaporation requir+ sev]al h\rs4 ,! plants 7 collect$ by ,dr4 ,c4 ,dwight ,m>%1 9 *>ge ( ! field inve/igations at ,hugo1 ,colo4 #aee ,all extracts f dri$ mat]ial 7 made at ,wa%+ton4 ,,*ronic ,,cases4 ,exp]im5t ,no4 #f4--;,febru>y #ai1 #aijf1 a l>ge gray rabbit weigh+ #b1jee4c grams 0 f$ ) #fj c4c4 ( fluid repres5t+ ! conc5trat$ aque\s extract ( #bej grams ( ! fre% ,a/ragalus mollissimus1 collect$ ,septemb] #ah1 #aije1 & pres]v$ 9 *lor(orm4 ,?is rabbit 0 v h>d to hold4 ,! e>s re/$ on ! body4 ,! temp]ature at ! "t ( fe$+1 #a4cj p4m41 0 #ajb4c;,f4 ,at #b4eg p4 m4 ! animal look$ dull b resi/$ h&l+4 ,at #c4cj p4m4 x ur9at$4 ,at #d4ae p4m4 ! temp]ature 0 #ih4e;,f41 ! pupils 7 ab\t ! same size z be=e fe$+1 & ! animal became mu* dull]4 ,! next day at #ab4ej p4m4 ! temp]ature 0 #ajb4d;,f41 & at ?is "t ! animal c\ld be h&l$ ) great] ease4 ,! animal ate 9 ! morn+4 ,! same am\nt ( extract 0 aga9 f$ at #a4bd p4 m4 ,at #a4ce p4m4 ! animal 0 mu* dull] & c\ld be turn$ on 8 back ) ease4 ,if di/urb$ he ran aga9/ ! wall z if utt]ly unconsci\s ( ! ob/ruction4 ,! animal _h s(t1 liquid1 br[n /ools & tri$ to lie d[n z mu* z possible4 ,if turn$ on its back ) ! feet up x w\ld /ay s almo/ indef9itely4 ,temp]ature1 #ajc4h;,f42 respiration v rapid4 ,at #b4dj p4m4 ! temp]ature 0 #ii4h;,f41 & ! animal di$ a few m9utes lat]4 ,aft] dea? ! pupils 7 mu* contract$4 ,! vessels ( ! dura cov]+ ! bra9 7 mu* dilat$1 b ! vessels inside ! bra9 7 n dilat$4 ,! /oma* walls 7 conge/$ & m>k$ ) num]\s pete*i & cov]$ ) mucus4 ,exp]im5t ,no4 #g4--,on ,febru>y #ai1 #aijf1 a :ite & br[n rabbit ^: temp]ature 0 #ajc4b;,f4 0 f$ #cj c4c4 ( aque\s fluid repres5t+ ! conc5trat$ extract ( #abe grams ( ! fre% ,a/ragalus mollissimus1 collect$ ,septemb]1 #aije1 & pres]v$ ) *lor(orm4 ,! rabbit weigh$ #a1ejb4e grams4 ,?is extract 0 f$ at #a4de p4m41 & at #d4ae p4m4 ! temp]ature 0 #ajb4f;,f41 b !re 7 no m>k$ symptoms4 ,! foll[+ day at #b4jd p4m4 ! temp]ature regi/]$ #ajb4e;,f4 ,! same am\nt ( extract 0 giv5 at #b4ji p4m4 ,! temp]ature at #d p4m4 0 #ii4h;,f41 ! animal 0 dull1 & ! pupils 7 p]haps a little small]4 ,! animal c\ld n be turn$ ov] )\t resi/ance4 ,! foll[+ day1 ,febru>y #ba1 at #a4cj p4m4 ! temp]ature 0 #ajb4f;,f41 & at #a4de ! same am\nt ( extract 0 giv54 ,at #a4ed p4m4 ! animal 0 mu* dull] & ! brea?+ 0 v rapid4 ,at #d4aj p4m4 ! temp]ature 0 #aja4c;,f4 ,! animal _h be5 dull ev] s9ce ! fe$+ 0 begun4 ,x nibbl$ food %ortly be=e ! la/ fe$+4 ,on ,febru>y #bc ! same am\nt ( extract 0 giv5 at #b4af p4m41 temp]ature #ii;,f4 ,! brea?+ 0 v rapid1 ! e>s %ak+1 & !re 0 a sleepy1 dull look ab\t ! animal4 ,at #c4cj p4m4 ! animal 0 dull1 b w\ld /ill walk ab\t if di/urb$4 ,at ?is "t ! animal weigh$ #a1dde4h grams4 ,at #d4cj p4m4 ! temp]ature 0 #ajb;,f4 & ! pupils 7 ab\t normal size4 ,!re 0 a m>k$ sleepy look ab\t ! animal1 :i* sat quietly 9 its cage4 ,febru>y #bd1 at #a p4m41 ! animal 0 v dull & c\ld ) ease be turn$ on its back ) its feet 9 ! air4 ,x w\ld sit 9 its cage p]fectly quiet4 ,! weight at ?is "t 0 #a1dag4e grams1 ! temp]ature #if4f;,f4 ,on ,febru>y #bf ! animal weigh$ #a1cfj4h grams4 ,x 0 dull & refus$ to eat4 ,! abdom5 felt v di/5d$ & tympanitic4 ,febru>y #bg ! weight 0 /ill #a1cfj4h grams1 & ! animal sat 9 its cage z if asleep1 ) eyes half clos$4 ,!re 0 no di>rhea & ! abdom5 0 v di/5d$4 ,at #aa4ae a4m4 !re 0 a g5]al convulsion & ! animal fell ov]4 ,at #ab m4 ! abdom5 seem$ ev5 m swoll51 ! animal 0 h>dly able to walk1 & x fell ov]1 utt]+ a cry4 ,pupils 7 ab\t normal--p]haps a little small]4 ,! animal di$ at #ab4aj p4m4 ,! po/-mortem1 made imm$iately aft] dea?1 %[$ ! abdom5 m>k$ly tympanitic1 & ! l>ge inte/9es c\ld be outl9$ ?r\gh ! abdom9al walls ) ease4 ,! l>ge inte/9es 7 ( a *ocolate color1 int5sely conge/$1 & m>k$ ) hemorrhages4 ,on op5+ ! abdom5 !re 0 a decid$ putrefactive odor1 & ab\t an ounce ( bloody fluid 0 f\nd 9 ! p]itoneal cavity1 toge!r ) fibr9 flakes4 ,! /oma* 0 pale1 ! fir/ ?ree in*es ( ! small inte/9e up to :]e x turn$ %>ply 7 pale1 & bel[ ?is ! inte/9es 7 inject$ & full ( gas & ( a d>k r$ color4 ,! kidneys 7 #c-a_/b c5timet]s long & 7 pale1 capsules easily peel$ (f2 cortex pale4 ,liv] pale & infect$ ) "s coccide4 ,! gall bladd] 0 "o-qu>t] in* wide & "o in* long4 ,sple5 a trifle pale2 lungs pale1 no?+ abnormal2 he>t relax$4 ,on op5+ ! /oma* gas & fluid1 ) "s food1 exud$4 ,! walls 7 pale1 b p9k 9 "s places4 ,!re 0 no m>k$ conge/ion or hemorrhage or p]=ation4 ,! mes5t]ic vessels 7 dilat$4 ,! upp] portion ( ! inte/9es conta9$ a little mucus-l fluid1 b l[] d[n became bloody1 & /ill l[] conta9$ pus-l fluid4 ,! walls 7 hemorrhagic4 ,! l>ge inte/9e conta9$ a s(t1 fecal-l fluid1 v f\l4 ,its walls 7 mu* conge/$ & full ( hemorrhagic po9ts4 ,! cortex ( ! supr>5al bodies 0 %>ply def9$1 ! m$ull br[ni%4 ,bra9 pale1 "s dural vessels well m>k$1 no clots or hemorrhages4 ,base ( bra9 pale4 ,no conge/ion se5 on cutt+ into ! bra94 ,sp9al cord %[$ no hemorrhages or lymph effusions4 ,exp]im5t ,no4 #h4--,on ,febru>y #ah1 #aijf1 at #b p4m41 a rabbit ^: temp]ature 0 #ajb4b;,f4 0 f$ ) ! aque\s extract ( #abe grams ( fre% ,a/ragalus mollissimus1 collect$ 9 ,septemb]1 #aije1 & pres]v$ 9 *lor(orm1 #cj c4c4 ( ! fluid be+ us$4 ,at #d4be p4m4 ! temp]ature 0 #ajb4d;,f4 ,no symptoms 7 not$4 ,?is rabbit weigh$ #a1fdd4c grams4 ,on ,febru>y #bj at #b4ji p4m4 ! temp]ature 0 #ajb4b;,f4 & ! rabbit %[$ no symptoms4 ,! same dose 0 repeat$ at #b4ae p4m4 ,at #d p4m4 ! temp]ature 0 #ajj4c;,f4 ,! rabbit 0 dull b c\ld n be turn$ ov] )\t a /ruggle4 ,febru>y #ba at #a4cj p4m4 ! temp]ature 0 #aja4d;,f4 ,! same am\nt ( extract 0 f$ at #a4de p4m4 ,at ?is "t ! animal 0 dull & brea!d m rapidly4 ,at #d4aj p4m4 ! temp]ature 0 #ig4c;,f4 ,next day ! same am\nt ( extract 0 aga9 giv5 at #b p4m4 ,at #b4af p4m4 ! brea?+ became rapid & ! animal dull]4 ,! e>s 7 direct$ =w>d4 ,at #d4ae p4m4 ! temp]ature 0 #aja4f;,f42 weight #a1geg4g grams2 animal slightly dull4 ,febru>y #bd1 temp]ature #ajb;,f41 weight #a1ghf grams4 ,m>* #e1 weight #a1gbi4c grams4 ,! animal 0 f$ at #c4bj p4m4 ) a conc5trat$ extract ( #abe grams ( ,a/ragalus mollissimus1 collect$ 9 ,septemb]4 ,temp]ature at "t ( fe$+ #ajj4d;,f42 #c4dj p4m41 no symptoms2 #d p4m41 temp]ature #ajb;,f4 ,m>* #g1 weight #a1fdd4c grams2 ,m>* #h1 weight #a1fgb4f grams2 ,m>* #aj1 weight #a1gja grams2 ,m>* #ab1 weight #a1feh4d grams2 ,m>* #ad1 weight #a1gja grams4 ,9 ?is case1 :]e ! same dose 0 giv5 9 a p]iod ( five days1 v little effect on ! rabbit 0 not$4 ,exp]im5t ,no4 #i4--,on ,m>* #a1 #aijf1 a black rabbit weigh+ #b1ffd4h grams 0 f$ ) a conc5trat$ aque\s extract ( #bej grams ( fre% ,a/ragalus mollissimus1 collect$ 9 ! fall ( #aije4 ,on ,m>* #e ! weight 0 #b1bif4c grams4 ,! animal 0 !n giv5 ! same am\nt ( extract4 ,dur+ ! aft]noon x pass$ mucus & ?ick pieces ( feces & 0 dull2 respiration v rapid4 ,m>* #f1 weight #b1bhb grams2 ,m>* #g1 #c p4m41 animal v dull & w\ld n eat2 sat hun*$ up1 b resi/$ be+ di/urb$3 weight #b1caj4e grams4 ,m>* #h1 weight #b1ahc grams2 ,m>* #i1 weight #b1jfi4e grams4 ,pupils dilat$2 f+] c\ld be run almo/ aga9/ ! eye1 provid$ ! la%es 7 n t\*$1 )\t ! animal w9k+ or pay+ any att5tion4 ,rabbit ate v little & _h n ur9at$ s9ce ! prec$+ day4 ,left e> _h fall5 to ! side z if ! animal 7 unable to support x4 ,weight1 #a1iab4h grams4 ,f ,m>* #i to ,m>* #aa1 #fg c4c4 ( cl\dy ur9e 7 void$4 ,?is did n cle> ) acetic acid4 ,left eye te>+4 ,m>* #aj1 head held to "r side4 ,m>* #ab1 weight #a1ghf grams4 ,left pupil small] ?an "r1 nei!r respond+ to light4 ,rabbit v weak4 ,m>* #ad1 weight #a1gbi4c grams4 ,w\ld n eat4 ,m>* #af1 weight #a1fdd4c grams4 ,"r pupil l>g] ?an left1 nei!r respond+ to light4 ,di>rhea pres5t4 ,brea?+ noisy4 ,9 sitt+ d[n %e rais$ h]self on h] =elegs1 evid5tly to take ! pressure (f h] abdom51 :i* 0 di/5d$4 ,if di/urb$1 %e w\ld butt aga9/ ! side ( ! cage1 app>5tly oblivi\s ( its pres5ce4 ,knee j]ks 7 v active1 almo/ a clonus4 ,reflex f t5do ,a*illis active4 ,m>* #ag1 =elegs spread out1 head fall+ to left side4 ,! temp]ature _h fall5 bel[ #id;,f4 & w\ld n regi/] on ! ord9>y cl9ical !rmomet]4 ,! e>s twit*$1 ! head 0 ?r[n back1 ! abdom5 0 di/5d$1 & ! rabbit gritt$ its tee?4 ,di$4 ,weight1 #a1eei4b grams4 ,bra9 & sp9al cord pale4 ,dural vessels pla9ly se5 b n m>k$4 ,inte/9al vessels conge/$4 ,/oma* pale2 no?+ app>5t macroscopically save a small p9-po9t ulc]4#aef ,he>t relax$4 ,po/-mortem exam9ation o!rwise negative macroscopically4 ,exp]im5t ,no4 #aj4--;,a m\se-color$ rabbit weigh+ #a1ibg4h grams 0 f$ ,febru>y #ah1 #aijf1 at #b4bf p4m41 ) a conc5trat$ aque\s extract ( #bej grams ( fre% ,a/ragalus mollissimus collect$ 9 ,septemb]1 #aije1 & pres]v$ 9 *lor(orm wat]4 ,! temp]ature ( ?is rabbit 0 #ajb4f;,f4 ,! fluid giv5 0 #dj c4c4 ,at #b4de p4m4 ! rabbit ur9at$ & at #b4eg p4m4 0 dull & ! respiration became rapid4 ,! animal !n abort$ & _h ?ree "y1 two ( :i* %[$ "s movem5t aft] bir?1 b 7 app>5tly premature4 ,on ,febru>y #bc ! temp]ature ( ?is rabbit 0 #ajb4i;,f4 at #a4dj p4 m4 ,%e 0 !n f$ ) ! same am\nt ( ! extract z be=e4 ,at #b4af p4m4 %e lay d[n & became mu* dull]2 left e> fall5 to side4 ,at #c4cj p4m4 ! rabbit 0 unable to /&4 ,! pupil ( ! eye expos$ to ! light 0 dilat$4 ,! animal di$ )\t a /ruggle4 ,! /oma* conta9$ mu* bloody mucus4 ,9 ! dep5d5t portion ( ! /oma* ne> ! c>diac end 7 m>k$ pete*i 9 ! walls1 ) bright-r$ blood 9 ! /oma* itself4 ,! he>t 0 relax$4 ,! inte/9es %[$ no?+ abnormal4 ,! dural vessels ( ! bra9 7 dilat$2 !re 0 a clot on ! dura ov] ! f\r? v5tricle4 ,sp9al cord & kidneys normal1 ! capsules n adh]+4 ,weight1 #a1ghf grams at dea?4 ,exp]im5t ,no4 #aa4--,on ,m>* #a1 #aijf1 a rabbit weigh+ #b1abf4b grams 0 f$ ) a conc5trat$ aque\s extract ( #bej grams ( ! fre% ,aragallus lamb]ti pres]v$ 9 *lor(orm wat]4 ,on ,m>* #e ?is dose 0 repeat$1 #cg4e c4c4 ( ! fluid be+ us$4 ,m>* #f ! rabbit weigh$ #a1ief grams2 ,m>* #g1 #a1iac4f grams2 ,m>* #h1 #a1hbh4e grams2 ,m>* #i1 #a1gja grams2 ,m>* #ab1 #a1fgb4f grams2 ,m>* #ad1 #a1fdd4c grams4 ,exp]im5t ,no4 #ab4 ,janu>y #ai1 #aijf1 a conc5trat$ aque\s extract ( #ejj grams ( ! fre% ,aragallus lamb]ti pres]v$ ) *lor(orm wat] 0 f$ to a rabbit weigh+ #ghe grams4 ,! temp]ature at #ab4aj p4m41 ! "t ( fe$+1 0 #aja4f;,f4 ,! temp]ature #a h\r & #dc m9utes lat] 0 #id4f;,f41 & ! animal di$ %ortly aft]1 %[+ ! same condition z occurr$ aft] fe$+ extracts ( ,a/ragalus mollissimus4 99 99 99 99 99 ,,footnotes3 #aef ,comp>e ,plnius1 ,w41 ,beziehung5 d4 ,ges*wrs u4 d4 ,erosion5 d4 ,mag5s z4 d4 funktionell4 ,/rung5 u4 ,krankh4 d4 ,d>mes1 ,ar*4 f4 ,v]dauungsk41 vol4 #ac1 pp4 #ahj1 #bgj1 #aijg1 & ,tixi]1 ,l41 ,anmies ,exp]4 ,consc4 aux ,ulcr4 du ,pylore1 ,comp4 ,r5d4 ,hebd4 ,soc4 de ,biol41 vol4 #fb1 p4 #ajda1 #aijg4 ,,pregnant ,,animals4 ,exp]im5t ,no4 #ac4--;,a l>ge1 gray1 pregnant rabbit weigh+ #b1hia4f grams 0 f$ on ,febru>y #bb1 #aijf1 ) #db c4c4 ( fluid1 correspond+ to ! aque\s extract ( #bej grams ( ,a/ragalus mollissimus collect$ 9 ,septemb] & ,octob]1 #aije1 & pres]v$ ) *lor(orm4 ,at #d p4m4 ! animal 0 dull1 b /ill resi/$ ef=ts to h&le4 ,on ,febru>y #bd ?is animal weigh$ #b1ggh4b grams1 & on ,febru>y #bf x bore a litt] ( sev5 "y rabbits4 ,"o or two ( ^! %[$ movem5ts ( ! limbs1 b 7 app>5tly immature4 ,?is rabbit on ,m>* #aj weigh$ #b1ecg4c grams2 ,m>* #ab1 #b1dch grams2 ,m>* #ad1 #b1ejh4i grams2 ,m>* #bb1 #b1did4g grams4 ,exp]im5t ,no4 #ad4--,on ,m>* #a1 #aijf1 a black rabbit weigh+ #b1gba4f grams 0 f$ at #ab4ae p4m4 ) a conc5trat$ aque\s extract ( #bej grams ( ! fre% ,a/ragalus mollissimus collect$ 9 ,septemb]1 #aije4 ,on ,m>* #b x weigh$ #b1dch grams2 at #b4eh p4m4 x /ill resi/$ ef=ts to turn x on its back2 at #c4ae p4m4 x c\ld be turn$ on its back ) ease4 ,m>* #f ! weight 0 #b1cch4h grams2 ,m>* #g ! animal 0 v dull1 w\ld n eat1 pupils dilat$1 h9d legs p>alyz$2 di$ dur+ ! night2 weight1 #b1bfg4i grams4 ,! /oma* walls 7 pale save at ! dep5d5t portion ne> ! c>diac end1 :]e !re 0 a hemorrhagic1 ulc]at$ area ab\t #a-a_/b by #a-a_/b in*es4 ,! inte/9es 7 full ( gas1 b n hemorrhagic4 ,! ut]us conta9$ eight immature foeti4 ,! ut]9e walls 7 hemorrhagic4 ,! kidneys weigh$ #i-a_/b grams2 _! m$ull 7 d>k & ! /raight tubules well def9$4 ,! c]ebral dural vessels 7 conge/$ & ! sp9al dural vessels 7 well def9$4 ,! bladd] 0 f\nd contract$4 ,! blood gave no b&s = me?moglob91 b %[$ m]ely ^? ( oxyhmoglob9 on spectroscopic exam9ation4 ,exp]im5t ,no4 #ae4--;,control exp]im5ts made by fe$+ wat] 7 negative1 except :5 a l>ge quantity 7#aej c4c47 ( wat] 0 giv5 to a rabbit weigh+ #a1jbj4e grams4 ,! animal di$ 9 #ab h\rs ) m>k$ pallor ( ! tissues 7hydrmia71 a pa?ological condition q diff]5t f t obta9$ by fe$+ extracts ( ! loco plants1 & no su* results 7 secur$ ) ! am\nt ( wat] us$ 9 our fe$+ exp]im5ts1 #ej to #gj c4c4 ,,subcutane\s ,,injections4 ,exp]im5t ,no4 #af4--,on ,febru>y #bh1 #aijf1 a :ite rabbit weigh+ #eha4b grams 0 inject$ subcutane\sly at #aj4ce a4m4 ) a conc5trat$ aque\s extract ( #hc grams ( fre% ,a/ragalus mollissimus collect$ 9 ,septemb]1 #aije1 & pres]v$ ) *lor(orm4 ,! temp]ature be=e injection 0 #ajb4a;,f4 ,at #a4dj p4m4 ! animal 0 dull2 at #c4ab p4m4 ! temp]ature regi/]$ #ii4h;,f4 ,! animal di$ dur+ ! night4 ,! po/-mortem exam9ation 0 negative4 ,/oma* pale2 he>t relax$ save left v5tricle1 :i* seem$ contract$2 dural vessels ( ! bra9 dilat$2 kidneys p]haps normal4 ,no microscopical exam9ation4 ,exp]im5t ,no4 #ag4--;,febru>y #bh1 #aijf1 at #aj4be a4m41 a gu9ea pig weigh+ #dif grams 0 inject$ subcutane\sly ) a conc5trat$ aque\s extract ( #hc grams ( ! fre% ,a/ragalus mollissimus pres]v$ 9 *lor(orm wat]4 ,at #a4dj p4m4 !re 0 muscul> twit*+4 ,! animal 0 dull & c\ld be easily turn$ on 8 back4 ,! h9d legs began to %[ weakness4 ,at #a4ej p4m4 ! h9d legs 7 almo/ completely p>alyz$ & ! animal c\ld be easily turn$ on 8 back4 ,muscles ( ! limbs twit*$ & sem5 0 expell$4 ,animal di$ at #b4ae p4m4 ,po/-mortem %[$ dural vessels ( cord & bra9 full ( blood4 ,/oma* p9k] ?an normal3 mes5t]ic vessels dilat$4 ,he>t almo/ empty ( blood4 ,kidneys conge/$4 ,,summ>y ,,( ,,fe$+ ,,exp]im5ts ,,on ,,rabbits4 ,^! exp]im5ts indicate t an acute =m ( poison+ may be induc$ by fe$+ conc5trat$ aque\s extracts ( ,a/ragalus mollissimus & ,aragallus lamb]ti f ,hugo1 ,colo41 & ,imp]ial1 ,nebr41 to rabbits1 & t if ! extract is giv5 9 small] & repeat$ doses a m prolong$ or *ronic condition may foll[4 ,! rabbits %[+ ! *ronic effects ( ^! plants exhibit symptoms :i* h a m>k$ p>allelism ) ^? report$ z occurr+ 9 l>g] h]bivora 7horses & cattle7 on ! range :5 loco$2 t is1 ! loss ( appetite 7,exp]im5t ,no4 #i71 ! emaciation & loss 9 weight 7,exp]im5t ,no4 #i71 ! dullness & /upor1 ) m or less ane/hesia 7,exp]im5t ,no4 #g71 ! di/urbance 9 ! visual function 7,exp]im5t ,no4 #i71 & ! m5tal symptoms 7,exp]im5t ,no4 #f74 ,! occasional abortion comp>es ) :at has be5 obs]v$ 9 l>g] animals4 ,! dri$ ,a/ragalus mollissimus & ,aragallus lamb]ti /ill reta9$ _! poison\s prop]ties1 z we 7 able to kill ) aque\s extracts ( ! dri$ plants made 9 ! laboratory "u ! prop] conditions4 ,,exp]im5ts ,,on ,,%eep4 ,exp]im5t ,no4 #a4--,on ,may #ca1 #aijf1 a %eep weigh+ #cb4b kilos 0 f$ ) a conc5trat$ aque\s extract ( #a1jjj grams ( ! fre% ,a/ragalus mollissimus pres]v$ 9 *lor(orm wat]4 ,! temp]ature at #aa o'clock1 ! "t ( fe$+1 0 #ajc4d;,f4 ,at #aa4de a4m4 ?is dose 0 repeat$4 ,at #ab o'clock ! temp]ature 0 #ajd4a;,f4 ,at #ab4de ! animal ur9at$4 ,at #a4aj p4m4 a simil> extract ( #b1jjj grams 0 f$4 ,! total liquid us$ 0 #a1ejj c4c4 ,on ,june #a no symptoms 7 not$4 ,on ,june #e an extract ( #c1jjj grams ( fre% ,aragallus lamb]ti & #c1jjj grams ( ,a/ragalus mollissimus 0 f$4 ,aft] fe$+ ?is ! animal c\ld be easily turn$ ov] on its back & its e> prick$ ) impunity4 ,! animal at ?is "t weigh$ #cj4h kilos4 ,on ,june #f1 at #aa a4m41 ! temp]ature 0 #ajd;,f4 ,! %eep _h num]\s s(t /ools1 & 0 v dull1 & w\ld n eat4 ,on ,june #g ! temp]ature 0 #ajc4g;,f4 & ! %eep /ill refus$ to eat4 ,on ! #h? ! temp]ature 0 #ajc4b;,f4 at #aj4dj a4m41 & ! /ools 7 /ill num]\s & s(t4 ,!re 7 !n f$ #fdj c4c41 repres5t+ ! aque\s extract ( #d1jjj grams ( ! fre% ,aragallus lamb]ti4 ,! animal c\ld be easily turn$ on its back4 ,x weigh$ at ?is "t #bh4eg kilos4 ,on ,june #i1 at #aj4dg a4m41 ! temp]ature 0 #ajc4d;,f4 ,! %eep /ill did n eat1 b _h no di>rhea4 ,x n[ weigh$ #bg4i kilos1 & ! temp]ature 0 #ajc;,f4 at #aj4de a4m4 ,on ,june #ac ! animal began to eat1 & #a1gjj c4c4 ( fluid1 repres5t+ #e1ejj grams ( ! fre% ,aragallus lamb]ti1 7 f$4 ,! temp]ature at #ab4cj p4m4 0 #ajc;,f4 ,on ,june #ad ! temp]ature 0 #ajc4d;,f41 ! animal weigh$ #bh4c kilos1 & refus$ food4 ,on ,june #af ! weight 0 #bh4c kilos2 ! temp]ature at #b p4m4 0 #ajc4e;,f4 ,!re 0 no di>rhea4 ,on ,june #ai ! aque\s extract ( #a1jjj grams ( ! dri$ ,a/ragalus mollissimus 0 f$ ) #dbj c4c4 ( wat]4 ,! temp]ature 0 #ajb4f ,f4 ,on ,june #bj ! temp]ature 0 #ajb4i;,f4 at #aj4de a4m4 ,on ,june #ba #ejj c4c41 repres5t+ ! aque\s extract ( #a1jjj grams ( ! dri$ ,a/ragalus mollissimus1 7 aga9 f$4 ,! animal n[ weigh$ #bf4i kilos4 ,on ,june #bf ! animal weigh$ #bf kilos1 & its gait 0 v unc]ta94 ,! temp]ature 0 #ajd4b;,f4 ,x 0 f$ #cjj c4c4 ( fluid1 repres5t+ ! extract ( #djj grams ( ! dri$ ,a/ragalus mollissimus4 ,on ,june #bi ! animal weigh$ #bf4h kilos & ! temp]ature 0 #ajb4h;,f4 ,x 0 f$ ! extract ( #a1jjj grams ( dri$ ,a/ragalus mollissimus 9 #ejj c4c4 ( wat]4 ,on ,june #cj1 at #aj4de a4 m41 ! temp]ature 0 #ajd4b;,f4 ,! animal 0 v dull & di$ at night4 ,at autopsy ! inte/9es & /oma* m]ely appe>$ pale4 ,!re 7 no worms1 & ! lungs & o!r organs appe>$ normal4 ,exp]im5t ,no4 #b4--;,a lamb weigh+ #ae4d kilos 0 f$ on ,july #f1 at #a4aj p4m41 ) #fdj c4c4 ( fluid1 repres5t+ ! extract ( #b1jjj grams ( ,a/ragalus mollissimus4 ,at #a4ag p4m4 ! animal c\ld be turn$ on its back1 & x rega9$ its feet ) difficulty4 ,at #a4bd p4 m4 x ur9at$ & _h a /ool4 ,! lamb di$ dur+ ! night4 ,! autopsy ! foll[+ morn+ %[$ ! he>t fill$ ) clots2 lungs normal save = hypo/atic conge/ion4 ,! c]ebral & dural vessels 7 dilat$4 ,ab\t #a-a_/b teaspoonfuls ( bloody s]um 7 f\nd at ! base ( ! bra94 ,!re 0 none 9 ! lat]al v5tricles1 & no clots4 ,! kidneys exhibit$ no m>k$ conge/ion4 ,!re 0 no fluid f\nd 9 ! p]itoneal or ! pleural or p]ic>dial cavities4 ,! fir/ /oma*1 h[ev]1 conta9$ small hemorrhagic spots1 & ! second 0 black4 ,!re 7 small hemorrhages 9 ! inte/9es4 ,exp]im5t ,no4 #c4--;,july #ac1 #aijf1 a %eep weigh+ #ai4e kilos 0 f$ ) #fdj c4c4 ( fluid1 repres5t+ ! extract ( #b1jjj grams ( ,aragallus lamb]ti4 ,! temp]ature at ! "t ( fe$+1 #a4aj p4 m41 0 #aje4c;,f4 ,at #a4di p4m4 ! %eep c\ld be easily turn$ on its back4 ,at #b4bc p4m4 ! temp]ature 0 #ajc4f;,f4 ,at #c4db p4m4 ! temp]ature 0 #ajc4e;,f4 ,at #d4bj p4m4 ! respiration 0 fairly rapid4 ,on ,july #ad1 at #aa4ae a4m41 ! temp]ature 0 #ajc4f;,f4 ,! %eep w\ld run ab\t b c\ld easily be turn$ ov]4 ,x _h n eat51 b !re 0 di>rhea pres5t4 ,july #ae1 at #c4cj p4m41 ! temp]ature 0 #ajd;,f4 ,! animal _h eat54 ,on ,july #ag ! temp]ature 0 #ajd;,f4 & ! animal weigh$ #ah4h kilos4 ,on ! #bg? x weigh$ #ag4b kilos2 on ,augu/ #bi1 #bj4h kilos4 ,exp]im5t ,no4 #d4--;,a lamb weigh+ #ai kilos 0 f$ ,augu/ #ba1 #aijf1 ) #gdj c4c41 repres5t+ ! aque\s extract ( #b1ejj grams ( ! fre% ,a/ragalus mollissimus1 %ipp$ to ,wa%+ton 9 ,septemb]1 #aije4 ,?is animal ate at night1 b ! foll[+ day 0 dull4 ,:5 se5 on ,augu/ #bg !re 0 di>rhea pres5t & ! animal 0 /ill dull4 ,on ! #bh? ! animal di$1 weigh+ #af4g kilos4 ,!re 0 no autopsy on acc\nt ( decomposition4 ,exp]im5t ,no4 #e4--;,a lamb weigh+ #ae4f kilos 0 f$ on ,septemb] #d1 #aijf1 ) an aque\s extract repres5t+ #c1ejj grams ( ! dri$ ,aragallus lamb]ti1 #a1jjj c4c4 ( wat] be+ us$4 ,! temp]ature at ! "t ( fe$+ 0 #ajd4c;,f4 ,at #b4dh p4m4 ! animal on ris+ to its feet develop$ a slight tremor ( ! =e legs & %[$ m>k$ dis9cl9ation to /& on its feet4 ,! temp]ature 0 #ajd;,f4 ,! animal di$ at #d4be p4m4 ,! po/-mortem 0 negative1 save = "s r$d5+ ( ! second /oma*4#aeg ,^! fe$+ exp]im5ts 9 %eep c n be consid]$ quantitative1 because1 z is %[n lat]1 aque\s extracts ( dri$ plants are (t5 inactive1 yet poison\s pr9ciples may be obta9$ f ! plants by treatm5t ) dige/ive fluids4 ,extracts ( dri$ loco plants v>y mu* 9 _! toxicity2 ) "s ! writ] 0 unable to kill rabbits1 ev5 :5 an extract ( #cjj grams ( ! dri$ plant 0 us$4 ,x is int]e/+ to note t :5 ! field /ation 0 e/abli%$ at ,hugo1 ,colo41 9 #aije1 almo/ all ! aque\s extracts ( dri$ specim5s s5t to ,wa%+ton w\ld produce ! acute symptoms ( poison+ 9 rabbits1 b dur+ ! ?ird season ( its exi/5ce _m ( ! samples s5t f ! same area 7 mu* less active1 if n inactive4 99 99 99 99 99 ,,footnotes3 #aeg ,!re 0 a slight odor ( *lor(orm notic$ on op5+ ! /oma*1 s t p]haps ! imp]fect removal ( ! *lor(orm due to a hurri$ evaporation ( ! extract %\ld be tak5 into consid]ation 9 ?is case4 ,,laboratory ,,exp]im5ts--,,*emical4 ,! fact t ! aque\s extract ( #ejj grams ( ! fre% ,a/ragalus mollissimus1 or ( #bjj grams 79 "s cases #ajj grams7 ( ! dri$ plant1 :5 f$ by m\?1 w\ld regul>ly kill a rabbit weigh+ ab\t #ijg grams1 ) c]ta9 def9ite cl9ical symptoms & pa?ological lesions1 0 at fir/ arbitr>ily select$ z our te/ to aid 9 ! isolation ( ! active pr9ciple4 ,lat] ! production ( *ronic symptoms by ! aque\s extract or dige/ion ( #bjj grams ( ^! dri$ plants giv5 9 doses ( #ajj grams ea* on two successive days 0 consid]$ ess5tial4 ,c>nivora1 su* z dogs & cats1 vomit s easily z to r5d] !m unsuitable = ^! inve/igations4 ,! aque\s extract 0 di/ill$ ) & )\t /eam1 also aft] acidify+ ) sulphuric acid1 & likewise aft] ! addition ( magnesium oxid1 b 9 all cases ! di/illate 0 inactive4 ,! conc5trat$ aque\s extract 0 %ak5 by ! ,drag5dorff me?od ) petroleum e!r1 b5zol1 *lor(orm1 e!r1 & amyl alcohol1 bo? 9 alkal9e & acid condition1 b ! %ak+s yield$ no physiologically active body4 ,%ak+s by ! ,otto-,/as me?od also prov$ inactive4 ,lead acetate1 lead subacetate1 silv] nitrate1 m]curic *lorid1 alcohol1 phosphotung/ic acid1 tri*loracetic acid1 ammonium hydrate1 sodium c>bonate1 sodium hydrate1 ,may]'s solution1 uranyl acetate1 silv] oxid1 & b>ium c>bonate also fail$ to remove ! active con/itu5t4 ,!y gave heavy precipitates 9 all cases1 b ^! prov$ inactive4 ,hydrocyanic acid 0 s\ght = ) negative results4 ,! pa?ological lesions 9 ! v acute cases sugge/$ 9 "s respects oxalic acid1 a sapon91 a metal1 or p]haps a toxalbum9 z ! active pr9ciple1 b none ( ! precipitants = sapon9s1 su* z lead & copp]1 or ! magnesium oxid me?od yield$ a body :i* 0 active4 ,proteids 7 exclud$ by ! fact t ! v>i\s proteid precipitants--alcohol1 tri*loracetic acid1 lead subacetate1 m]curic sulphate or *lorid1 & salt+ out ) ammonium sulphate & sodium *lorid 7complete saturation & half saturation7--fail$ to give an active precipitate4 ,glucosidal or alkaloidal bodies 7 also exclud$4 ,on dialys+ = tw5ty-f\r h\rs1 "s ( ! active pr9ciple w5t into ! dialysate & "s rema9$ 9 ! dialys]4 ,e!r yield$ a precipitate f alcoholic solution :i* fail$ to kill4 ,! possibility ( ! activity ( ! plants be+ due to its normal acidity 0 exclud$ by neutraliz+ ! extract ) sodium hydrate & precipitat+ ! salts ) alcohol4 ,! filtrate prov$ active aft] remov+ ! alcohol4 ,! negative results 9 look+ = active alkaloidal1 or glucosidal1 or proteid bodies sugge/$ t p]haps ! action 0 due to "s inorganic con/itu5t4 ,! writ] !n boil$ ! extract ?ree m9utes & z ! filtrate 0 /ill f\nd active & ! proteid precipitate inactive became conv9c$ ( ! inorganic nature ( ! active con/itu5ts1 & f9ally inc9]at$ ! plant4 ,! acid extract f ?is 0 also active1 b dea? 0 delay$ sev]al h\rs4 ,?is 0 believ$ to be due to ! insoluble =m into :i* ! comp\nd 0 conv]t$4#aeh ,9 fact1 ! "q ( solubility & ! avoidance ( an acid reaction1 :i* ( itself may kill1 are ! ma9 po9ts to keep 9 m9d4 ,^! exp]im5ts indicat$ t ! injuri\s action t[>d rabbits ( ! ,a/ragalus mollissimus & ,aragallus lamb]ti collect$ at ,hugo1 ,colo41 0 due to "o or m inorganic con/itu5ts1#aei b x does n foll[ t all loco plants h ! same poison\s pr9ciple nor t ! same species occurr+ on all soils has ! same poison\s action4#afj ,( ,a/ragalus mollissimus f ,imp]ial1 ,nebr41 collect$ 9 #aijf1 #bjj grams 7 a%$ 9 a plat9um b[l & extract$ ) wat]4 ,?is aque\s extract :5 neutraliz$ produc$ no m>k$ symptoms 9 a rabbit & ! weight ( ! animal rema9$ ab\t ! same4 ,! a% undissolv$ aft] ?is extraction 0 !n treat$ ) acetic acid & wat] ov]night1 & aft] c>efully evaporat+ (f ! acetic acid on ! ba? 7te/$ by litmus pap]7 ! residue 0 f$1 p>tly 9 solution & p>tly susp5d$ 9 wat]1 to a rabbit weigh+ #a1hjj4b grams4 ,next day ! rabbit weigh$ #a1gga4h grams1 %[$ p>alysis ( ! limbs1 & di$ dur+ ! morn+4 ,! /oma* 0 int5sely r$d5$ & contract$4 ,an extract ( a simil> a% 0 made by boil+ ! same am\nt ) a l>ge quantity ( #id p] c5t alcohol4 ,?is 0 evaporat$ 9 vacuo & tak5 9 wat] & f$ to a rabbit weigh+ #a1dei4i grams4 ,on ! six? day ! animal di$1 hav+ lo/ #gj4i grams 9 weight4 ,! /oma* %[$ r$d5+ b no ulc]s4 ,an acetic acid aque\s extract1 made f ! a% aft] ! alcoholic extraction1 prov$ inactive1 %[+ t ! alcohol _h remov$ ! active bodies4 ,a #gj p] c5t alcohol extract ( ano!r a%$ lot prov$ active1 kill+ ! rabbit ov]night4 ,( ,a/ragalus mollissimus f ,imp]ial1 ,nebr41 #bjj grams 7 a%$ 9 a plat9um b[l & ! a% treat$ ) acetic acid wat]4 ,aft] free+ f acid1 "o half ( ! solution & emulsion 0 f$ "o day & ! second half f$ ! foll[+ day4 ,! rabbit at ! "t ( fe$+ weigh$ #a1bge4g grams4 ,f\rte5 days lat] ! animal di$1 weigh+ #a1aje4f grams4 ,no autopsy4 ,a simil> extract ( ! a% f betwe5 #ajj & #aej grams ( ! same dri$ plant produc$ dea? 9 a rabbit weigh+ #a1aij grams 9 two h\rs & fifty-eight m9utes4 ,! acetic acid extract ( ! a% ( #abe grams ( a mixture ( ! dri$ ,a/ragalus mollissimus & ,aragallus lamb]ti receiv$ f ,hugo1 ,colo41 ,june1 #aijg1 aft] free+ f acid1 0 f$ to a rabbit weigh+ #a1cjd grams on ,july #bi4 ,on ,july #cj x weigh$ #a1ccb4d grams4 ,augu/ #a x weigh$ #a1bai grams1 & x di$ ! same day4 ,! /oma* 0 r$d5$ & %[$ ulc]s4 ,a simil> extract f #bej grams ( ! same dri$ plants on boil+ gave a heavy precipitate1 b ?is precipitate 0 inactive1 :ile ! filtrate kill$ a rabbit 9 f\r h\rs4 ,( dry ,aragallus lamb]ti collect$ 9 ,septemb]1 #aijf1 #bjj grams 7 extract$ ) wat] & f$ to a rabbit weigh+ #a1eaf4g grams4 ,two days lat] ! animal weigh$ #a1cfj grams & di$ ! same day4 ,! a% f #bjj grams ( ! same dri$ plant 0 extract$ ) acetic acid1 & aft] evaporat+ (f ! acid ?is 0 f$ to a rabbit weigh+ #b1jde4c grams4 ,sev5 days lat] ! animal weigh$ #a1gbi4c grams1 hav+ lo/ #caf grams 9 weight4 ,! a% f #bej grams ( ! same species ( plant1 aft] simil> treatm5t ) acetic acid1 induc$ dea? 9 a rabbit weigh+ #b1jfi grams 9 #b h\rs & #bj m9utes4 ,! /oma* 0 inflam$4 99 99 99 99 99 ,,footnotes3 #aeh ,"w is n[ be+ done by ! writ] on ! inorganic con/itu5ts ( v>i\s plants4 #aei ,scatt]$ ?r\gh\t ! vet]9>y lit]ature "o f9ds cases ( poison+ 9 animals ) symptoms simil> to ^? occurr+ 9 loco$ animals :i* are attribut$ to eat+ plants gr[n on a peculi> soil1 z 9 ,os][1 ,ueb] ,krankh4 d4 ,pf]de1 wel*e ,aehnli*keit mit d] ,c]ebro-sp9al m5+itis hab51 ab] dur* ,v]giftung5 mit ,grs]n von ,salzgrnd5 7,salzmoor57 v]ursa*t w]d51 ,j\rn4 f4 ,allgem4 ,vet]9r-,m$ic91 ,/4 ,pet]sburg1 p4 #dhf1 #aijf4 ,ab/ract 9 ,jahresb]4 b] d4 ,lei/ung5 auf dem ,gebiete d4 ,vet]9r-,m$ic91 vol4 #bf1 p4 #bbf1 #aijf4--;,comp>e also tude sur ,quelques ,plantes ,vnneuses des ,regions ,calcaires1 ,bul4 ,soc4 ,c5t4 de ,md4 ,vt41 vol4 #dh1 p4 #cgh4 #ahid4 #afj ,aft] complet+ ?is "w ! writ] f\nd t ,sayre _h said t he _h ! sugge/ion t ! h>m com+ f ?is plant is due to ! inorganic con/itu5ts2 ?is clue has be5 foll[$ up1 b l ! o!rs has br\ght u no ne>] to ! solution ( ! problem4 ,kans4 ,acad4 ,sci4 ,trans41 vol4 #ah1 p4 #add4 #aijc4 ,,effect ,,( ,,! ,,aque\s ,,extract ,,( ,,a%$ ,,loco ,,plants4 ,! filtrate f ! a% f #bjj grams ( dri$ ,a/ragalus mollissimus1 f ,imp]ial1 ,nebr41 aft] simil> treatm5t ) acetic acid wat] & fre$ f free acid1 kill$ a rabbit 9 sev]al h\rs4 ,hydro*loric acid also r5d]$ ! toxic ag5t ( ! a% soluble 9 wat]1 b prov$ unsuitable = our "w1 z x 0 f\nd impossible to obta9 neutral residues by m]e evaporation on ! ba?4 ,at fir/ "o ( ! heavy metals or memb]s ( ! ,h#b,s gr\p#afa 0 suspect$1 b on pass+ ,h#b,s into ! slightly acid extract ( ! a% no active precipitate result$1 b ! filtrate rema9$ active4#afb ,a special ,m>% te/ 01 h[ev]1 made = ars5ic & antimony ) negative results4 ,a te/ = tung/5 ) z9c & hydro*loric acid prov$ negative4 ,memb]s ( ! ammonium sulphid gr\p 7 !n suspect$1 b :ile ammonium hydrate alone gave a heavy :ite precipitate1 ?is precipitate1 z also ! black "o ) ammonium sulphid1 prov$ inactive save :5 n ?or\ghly fre$ f acid 7us$ = solution74 ,! action ( ?is ammonium sulphid precipitate on rabbits 0 wat*$ = sixte5 days1 b )\t result4 ,nev]!less1 ! writ] /ill suspect$ "s ( ! r>e e>?s4#afc ,se/9i#afd _h f\nd t if c]ta9 plants 7 n\ri%$ ) a solution ( a b]yllium salt1 9 ! a% ( ^! plants c\ld be %[n ! pres5ce ( b]yllium4 ,two grams ( b]yllium *lorid 7 f$ 9 aque\s solution to a rabbit weigh+ #a1hjj4b grams4 ,9 f\r days ?is animal lo/ #bda grams & di$4 ,! /oma* %[$ ! same g5]al pallor se5 9 *ronic loco$ rabbits1 b no ulc]s4 ,! te/s = b]yllium by ,se/9i's me?od1 h[ev]1 fail$ to %[ b]yllium 9 ! active loco plants exam9$4 ,?orium *lorid1 c]ium *lorid1 & lan?anum *lorid 9 #b-;gram doses & zirconium *lorid 9 #c-;gram doses produc$ no *ronic symptoms 9 rabbits or1 9 fact1 any di/urbance4 ,titanium *lorid1 #b4e grams1 evaporat$ 9 ! air & !n f$ 9 an emulsion to a rabbit1 also prov$ inactive1 b ?is inactivity may h be5 due to its insolubility4 ,?allium nitrate c4 p41 9 aque\s solution1 9 #b-;gram doses1 kill$ a rabbit weigh+ #b1aed4f grams 9 two h\rs & fifte5 m9utes4 ,! /oma* 9 ?is case1 :ile p9k1 0 n hemorrhagic4 ,zirconium *lorid has an a/r+5t ta/e1 & if f$ repeat$ly w cause ! metallic a/r+5t action4 ,on boil+ an acetic acid solution ( ! a% ) sodium acetate a precipitate =m$4#afe ,! pres5ce ( zirconium 0 ?us suspect$ & ,dr4 ,e4 ,c4 ,sullivan1 ( ! ,unit$ ,/ates ,geological ,survey1 e/imat$ x to be pres5t 9 ! a% ( a sample ( ,aragallus lamb]ti 9 ab\t #j4ja p] c5t zirconium oxid1 ) also #j4a p] c5t titanium dioxid4#aff ,zirconium *lorid1 #c grams1 0 f$ 9 aque\s solution to a rabbit weigh+ #hej4e grams4 ,?is rabbit lo/ #if grams 9 sev5 days1 & 0 !n f$ #c grams m ( ! same solution & ! foll[+ day #b grams m4 ,x di$ eight days lat]1 weigh+ #fef grams4 ,! /oma* & inte/9es 7 contract$1 b %[$ no ulc]s4 ,h[ev]1 #d grams kill$ a rabbit 9 two h\rs & ?irty-two m9utes4 ,! filtrate1 aft] treat+ an active solution ( ! a% ) hydrog5 p]oxid1 prov$ active1 ?us %[+ t zirconium 0 n entirely responsible = ! poison\s action4 ,yttrium1 :ile n f\nd 9 ! plant1 0 adm9i/]$ z yttrium *lorid to a rabbit weigh+ #a1ecj grams 9 #b-;gram doses 9 solution4 ,?is animal ga9$ #aac4d grams 9 five days4 ,didymium *lorid c4 p41 9 #c-;gram doses1 0 f$ to a rabbit weigh+ #a1jbj grams4 ,?is rabbit lo/ #gj grams 9 f\r days4 ,! adm9i/ration ( manganese acetate#afg 9 #b-;gram doses 0 foll[$ by a ga9 9 weight ( a rabbit ( #db4e grams1 :ile a dose ( #c grams kill$ a rabbit weigh+ #a1jgg grams 9 two h\rs & ?irty m9utes4 ,wohlwill#afh has emphasiz$ ! fact t ! memb]s ( ! iron gr\p owe _! comp>ative h>mlessness to n be+ absorb$ by ! ga/ro-inte/9al tract4 ,no z9c 0 f\nd 9 ! plant4#afi ,x is well recogniz$ t potassium salts giv5 hypod]mically are decid$ly toxic & t ammonium salts giv5 p] os w kill1 s t ! writ] consid]$ ! possibility ( o!r memb]s ( ! gr\p be+ responsible = ! injuri\s action4 ,! fact t ! alkal9e di/illate ( ! plant prov$ inactive elim9at$ ! ammonium salts4 ,csium *lorid c4 p41 #b grams1 0 f$ 9 aque\s solution to a rabbit weigh+ #a1jgg4b grams4 ,9 six days ?is animal lo/ #bee grams 9 weight1 :5 x di$4#agj ,a second rabbit1 weigh+ #a1jbj4e grams1 0 f$ ) #b grams ( ! same solution & lo/ #cfh grams 9 tw5ty-"o days4 ,! spectroscopic te/1 h[ev]1 fail$ to %[ csium 9 ! a%$ plant4 ,rubidium *lorid c4 p41 9 #b-;gram doses1 prov$ inactive4 ,! plat9um *lorid precipitate f ! extract ( ! plant prov$ inactive4 ,! fact t ! filtrate aft] precipitation ( ! phosphates by t9 & nitric acid & ,h#b,s 0 active exclud$ ! phosphoric acid radical1 & ! filtrate aft] treatm5t ) ,ba,c,o#c & ,ag,o be+ active exclud$ ! ,h#b,,s#d & ,h,cl radicals z ! toxic body4 ,fluor9e 0 prov$ to be abs5t4 ,a radio-active sub/ance 0 suspect$1 b ,dr4 ,l4 ,j4 ,briggs1 ,physici/ ( ,bureau ( ,plant ,indu/ry1 report$ t ! dri$ plant %[$ no special am\nt ( radio-activity4#aga ,p[] & ,cambi]1 ,sayre1 & ,k5n$y _h previ\sly call$ att5tion to ! abundance ( calcium 9 ! plant1 & ! writ]'s inve/igations confirm ?is4 ,ph>macologi/s are av]se to believ+ calcium giv5 p] os poison\s4 ,! writ] has1 h[ev]1 f$ #e grams ( ! acetate ( calcium 9 solution to a rabbit weigh+ #feb grams4 ,?is animal di$ 9 two h\rs1 ) m>k$ irritation ( ! /oma*1 ! result be+ due to ! s-call$ salt action4 ,mu* l>g] am\nts 7 f$ 9 divid$ doses1 b )\t injury4 ,calcium phosphate & calcium sulphate 9 #b-;gram doses prov$ h>mless to a rabbit weigh+ ab\t #a1djj grams4 ,?ree grams ( magnesium acetate#agb 7 f$ 9 solution = five successive days to a rabbit weigh+ #a1dag grams1 b )\t app>5t effect4 ,/rontium acetate c4 p41 9 #b-;gram doses1 likewise caus$ no di/urbance4#agc ,no /rontium 9 any am\nt recognizable by *emical te/s 0 prov$ 9 ! plant4 ,s t by a process ( exclusion ! writ] 0 =c$ to ?9k ( b>ium z ! ma9 cause ( ! tr\ble4 ,! writ] not$ t if ! a%$ plant 0 extract$ ) ,h#b,,s#d wat] & ?is extract fre$ f sulphuric acid ) ,pb,c,o#c & ,h#b,s ! solution prov$ inactive to rabbits & also t aft] ?is extraction ! acetic acid extract ( ! a% fail$ to kill4 ,9 o!r words1 ! sulphate ( our body 0 insoluble 9 wat]4 ,at times 9 pass+ ,h#b,s into active solutions ( ! a%$ plant fre$ f ! acetic acid by evaporation ! filtrate & likewise ! precipitate 7 inactive4 ,noyes & ,bray#agd h not$ t if ,h#b,s is pass$ into c]ta9 solutions 9 ! pres5ce ( an oxydiz+ ag5t1 su* z f]ric iron1 ,h#b,,s#d w\ld be =m$1 :i* w\ld ?r[ any b>ium out ( solution4 ,9 "o blood-pressure record made ) a dog 7vagi n]ves cut71 a rise 9 blood pressure 7a *>act]i/ic physiological action ( b>ium7 0 se5 to foll[ ! intrav5\s injection ( ! aque\s extract ( ! plant1 9 spite ( its normal acid reaction4 ,accid5tally ! writ] f\nd t ,spr5gel#age _h report$ ! pres5ce ( b>ium 9 ,a/ragalus exscapus1 a closely alli$ plant4 ,b>ium has also be5 f\nd 9 ! vegetable _w by ,s*eele 9 #aghh1 & lat] by ,eck>d1#agf :o f\nd x 9 bee*1 :ile ,=*hamm]#agg prov$ x 9 bir*1 & ,lutt]kor? f\nd x 9 ! soil ( ! same area 9 :i* ,eck>d work$4 ,dworzak#agh not$ ! occurr5ce ( traces ( ?is elem5t 9 :eat gr[n along ! ,nile1 & ,knop#agi f\nd x 9 ! soil4 ,doctor ,balf\r1 ( ,kh>tum1 ,egypt1 in=m$ ! writ] t he knew ( no cases 9 :i* ?is b>ium 9 :eat _h produc$ poison+4 ,hornb]g]#ahj f\nd b>ium bo? 9 ! r$ bee* gr[n 9 ,g]many & 9 ! soil on :i* ^! trees grew4 ,x has also be5 claim$ t v>i\s m>9e plants may take up b>ium f ! sea4#aha ,hillebr&#ahb has call$ att5tion to ! fact t ! igne\s rocks ( ! ,rocky ,m\nta9s %[$ a high] p]c5tage ( b>ium ?an rock f o!r portions ( ! ,unit$ ,/ates1 s t "u ^! conditions "o might expect ! pres5ce ( b>ium 9 plants gr[+ 9 ?is region4 ,a sample ( ,aragallus lamb]ti & "o ( ,a/ragalus mollissimus 7 s5t to ! ,bureau ( ,*emi/ry = spectroscopic exam9ation = v>i\s elem5ts & !y report$ traces ( b>ium 9 ea*4#ahc ,) ^! argum5ts ! writ] felt sure ( ! pres5ce ( b>ium1 & ! matt] 0 discuss$ ) ,dr4 ,e4 ,c4 ,sullivan1 ( ! ,unit$ ,/ates ,geological ,survey1 & he k9dly corroborat$ ! conclusions rea*$ z to ! pres5ce ( b>ium1 controll+ its pres5ce by means ( ! spectroscope1 & e/imat$ x r\ghly z #j4a p] c5t ,ba,o 9 ! a% ( a sample ( ,aragallus lamb]ti 7#f4c milligrams ,ba,s,o#d 9 #d grams a%74 ,?is det]m9ation 0 made by ,hillebr&'s me?od4 ,kob]t has anticipat$ ?is result1 say+ t all plants are 9 ! position occasionally to take up b>ium comb9ations f ! soil1 & ! plants :i* ?us conta9 b>ium may act injuri\sly to m5 & animals4#ahd 99 99 99 99 99 ,,footnotes3 #afa ,swa91 ,r4 ,e41 & ,h>k9s1 ,w4 ,d4 ,ars5ic 9 ,vegetation ,expos$ to ,smelt] ,smoke4 ,j\rn4 ,am]4 ,*em4 ,soc41 vol4 #cj1 p4 #iae4 #aijh4--;,h>k9s1 ,w4 ,d41 & ,swa91 ,r4 ,e4 ,! ,*ronic ,ars5ical ,poison+ ( ,h]bivor\s ,animals4 ,j\rn4 ,am]4 ,*em4 ,soc41 vol4 #cj1 p4 #ibh1 #aijh4 #afb ,a simil> extract 0 s5t to ! ,bureau ( ,*emi/ry1 & t ,bureau also report$ an abs5ce ( ! elem5ts ( ! ,h#b,s gr\p4 #afc ,ba*em1 ,c4 ,ph>makologis*es b] e9ige ,edel]d54 ,ar*4 ,int]nat4 de ,ph>macodyn41 vol4 #ag1 p4 #cfc4 #aijg4 #afd ,se/9i1 ,f4 ,esp]4 di ,vegetaz4 del ,frum5to con ,so/ituz4 della ,gluc9a alla ,magnesia4 ,/az4 ,sp]4 ,agr>4 ,ital41 vol4 #bj1 p4 #bef4 #ahia4--;,di alcuni ,elem5ti ,*imici ,r>i a ,trov>si nei ,vegetabili4 ,/az4 ,sp]4 ,agr>4 ,ital41 vol4 #ae1 p4 #bij4 #ahhh4 ,,note4--,! ammonium sulphid precipitate 0 v small if ! phosphates 7 fir/ remov$ ) t9 & nitric acid4 #afe ,bhm1 ,c4 ,r4 ,d>/ellung d4 selt55 ,erd51 vol4 #a1 p4 #dj4 #aije4 #aff ,wait1 ,c4 ,e4 ,occurr5ce ( ,titanium4 ,j\rn4 ,am]4 ,*em4 ,soc41 vol4 #ah1 p4 #djb4 #ahif4 ,,note4--,!re seem to be no records ( any /udy ( ! ph>macological action ( titanium4 #afg ,comp>e ,jaks*1 ,r4 v4 ,ueb] ,mangantoxikos5 und ,manganophobie4 ,mn*4 ,m$4 ,wo*41 p4 #ifi4 #aijg4 #afh ,wohlwill1 ,f4 ,ueb] d4 ,wirkung d4 ,metalle d4 ,nickelgruppe4 ,ar*4 f4 ,exp]4 ,pa?41 vol4 #ef1 p4 #dji4 #aijg4 #afi ,lab&1 ,l4 ,zur ,v]breitung des ,z9kes im ,pflanz5rei*e4 ,zeits4 f4 ,unt]su*4 d4 ,nahrungs u4 ,g5ussmittel1 vol4 #d1 p4 #dhi4 #aija4 #agj ,csium occurs 9 v>i\s plants & ! possibility ( poison+ by ?is elem5t mu/ be consid]$4 ,x is hop$ t ! writ] may be able to und]take a m ?or\gh ph>macological /udy ( ?is elem5t4 #aga ,acqua1 ,c4 ,sull'accumulo di ,so/anze ,radioattive nei ,vegetali4 ,atti della ,reale ,accad4 dei ,l9cei1 #e s1 vol4 #af1 sem4 #b1 p4 #ceg4 #aijg4 #agb ,comp>e ,meltz]1 ,s4 ,j4 ,toxicity ( ,magnesium ,nitrate ,:5 ,giv5 by ,m\?4 ,sci5ce1 vol4 #bf1 p4 #dgc4 #aijg4 #agc ,burgassi1 ,g4 ,modificaz4 del ,ricambio p] ,azione dello ,/ronzio4 ,ar*iv4 di ,f>macol41 vol4 #f1 p4 #eea4 #aijg4 #agd ,noyes1 ,a4 ,a41 & ,bray1 ,w4 ,c4 ,sy/em ( ,qualitative ,analysis = ! ,common ,elem5ts4 ,j\rn4 ,am]4 ,*em4 ,soc41 vol4 #bi1 pp4 #afh1 #agb1 & #aia4 #aijg4 ,,note4--,b>ium sulphate is nontoxic on acc\nt ( its insolubility4 ,orfila f$ #af-bd grams to dogs )\t caus+ any di/urbance4 ,b>y1 ,a4 ,beitr4 z4 ,b>yumwirkung4 ,dorpat1 #ahhh1 p4 #be4 #age ,spr5gel1 ,c4 ,von d5 ,sub/anz5 d] ,ack]brume und des ,unt]grundes1 ,j\rn4 f4 ,te*n4 u4 ,o,ekon4 ,*em41 vol4 #c1 p4 #cac4 #ahbh4 #agf ,eck>d1 ,g4 ,e4 ,b>yt1 e9 ,be/&!il d] ,as*e des ,bu*5holzes4 ,annal4 d] ,*em4 u4 ,ph>m41 n4 s41 vol4 #bc1 p4 #bid4 #ahef4 #agg ,=*hamm]1 ,j4 ,g4 ,ueb] d5 ,e9fluss des ,ko*salzes auf die ,bildung d] ,m9]ali54 ,annal4 d4 ,physik u4 ,*emie1 vol4 #e1 p4 #ia4 #aije4--,lutt]kor?1 ,h4 ,kohl5sur] ,b>yt1 e9 ,be/&!il des ,s&/e9es 9 d] ,geg5d von ,gtt+54 ,annal4 d4 ,*em4 u4 ,ph>m41 n4 s41 vol4 #bc1 p4 #bif4 #ahef4 #agh ,dworzak1 ,h4 ,b>yt unt] d5 ,as*5be/&!il5 des4 gyptis*5 ,weiz54 ,l&w4 ,v]su*s4-,/at41 vol4 #ag1 p4 #cih4 #ahgd4 #agi ,knop1 ,w4 ,analys5 von ,nilabsatz4 ,l&w4 ,v]su*s4-,/at41 vol4 #ag1 p4 #fe4 #ahgd4--;,comp>e also ,dem\ssy1 ,e41 ,absorption p> les ,plantes de ,quelques ,sels ,solubles1 ,?se1 ,p>is1 #ahii4--,knop1 ,w41 ,e9ige neue ,resultate d] ,unt]su*ung b] die ,ernhrung d] ,pflanze1 ,b]4 4 ,v]h&l4 d4 knigl4 s*s4 ,gesells4 d4 ,wiss5s4 zu ,leipzig1 ,ma?4 ,phys4 ,cl41 vol4 #bi1 p4 #aac1 #ahgg4--,suzuki1 ,u41 ,c ,/rontium & ,b>ium ,replace ,calcium 9 ,phnogams8 ,bul4 ,coll4 ,agric4 ,tokio ,imp4 ,univ41 vol4 #d1 p4 #fi1 #aijj-aijb4 #ahj ,hornb]g]1 ,r4 ,ueb] d4 ,vorkomm5 d4 ,b>yums 9 d4 ,pflanze und im ,bod54 ,l&w4 ,v]su*s4-,/at41 vol4 #ea1 p4 #dgc4 #ahii4 #aha ,roscoe1 ,h4 ,e41 & ,s*orlemm]1 ,c4 ,treatise on ,*emi/ry1 vol4 #b1 p4 #dee4 #ahig4 #ahb ,hillebr&1 ,w4 ,f4 ,analysis ( ,silicate & ,c>bonate ,rocks4 ,dept4 ,int]ior1 ,u4 ,s4 ,geol4 ,survey1 ,bul4 #cje1 p4 #ah4 #aijg4 #ahc ,?is report came f ! ,plant ,analysis ,laboratory ( ! ,bureau ( ,*emi/ry1 a diff]5t "o f t :i* lat] controll$ ! writ]'s te/s quantitatively & qualitatively4 ,9 o!r words1 ! conclusions ( ! writ] z to ! pres5ce ( b>ium 7 controll$ by ?ree sep>ate individuals4 #ahd ,kob]t1 ,r4 ,kann e9 9 e9em ,pflanz5pulv] gefund5] abnorm hh] ,b>ytgehalt erklrt w]d5 dur* direkte ,aufnahme von ,b>yumsalze dur* die leb5de ,pflanze aus dem ,bod58 ,*em4 ,zeit41 vol4 #aj1 p4 #dia4 #ahii4 ,,note4--,! writ] has also f\nd b>ium 9 entirely diff]5t botanical families f ! loco-we$1 & x is hop$ a report c %ortly be made ( "s ( ^!4 ,,note4--,! fir/ sample ( a% analyz$ by ! ,bureau ( ,*emi/ry _h #j4ba p] c5t ,fe#b,o#c1 #j4ib p] c5t ,al#b,o#c1 #j4ih p] c5t ,ca,o1 #j4cg p] c5t ,mg,o1 #e4ej p] c5t ,si,o#b4 ,! second lot 0 only exam9$ = c]ta9 con/itu5ts1 & gave ,k#b,o1 #b4be p] c5t2 ,ca,o1 #a4bj p] c5t2 ,mg,o1 #j4da p] c5t2 ,p#b,o#e1 #j4eb p] c5t2 & ,,s#c1 #j4bd p] c5t4 ,,total ,,a% ,,det]m9ations ,,( ,,loco ,,plants4 ,! reports ( ! a% analyses ( ! loco plants %[ m>k$ v>iations 9 ! total am\nt ( ! a%4 ,?us1 f ,aragallus lamb]ti ,dyr5=? obta9$ #d4cb p] c5t & ,o',br9e #ac4eb p] c5t ( a%4 ,! ,bureau ( ,*emi/ry analyz$ two diff]5t samples ( ?is dri$ plant & report$ 9 "o case #aa4ae p] c5t & 9 ! second #aa4fd p] c5t ( a%4 ,o',br9e#ahe obta9$ #ac4eb p] c5t ( a% f ! same species4 ,! writ]'s analysis#ahf gave 9 "o sample ( ,aragallus lamb]ti1 collect$ at ,hugo1 ,colo41 9 #aijg1 #ah4h p] c5t ( a%2 a second lot 7#aijg71 #ab4dd p] c5t2 a ?ird 7#aijf71 #aa p] c5t1 & a f\r? 7,may1 #aije7 gave #cg4c p] c5t ( a%4#ahg ,"o lot f ,woodl& ,p>k1 ,colo4 7,octob]1 #aijf71 gave #f4d p] c5t4 ,"o lot f ,hugo1 ,colo4 7,octob]1 #aijg71 yield$ #i4f p] c5t4 ,9 ! case ( ,a/ragalus mollissimus1 ,w5tz obta9$ #f4gf p] c5t1 ,sayre #ab4ja p] c5t1 ,k5n$y #bj p] c5t1 ,o',br9e #ab4ae p] c5t1 :ile ! sample analyz$ by ! ,bureau ( ,*emi/ry gave #ah4d p] c5t ( a%4 ,"o sample f ,kit ,c>son ,c\nty1 ,colo4 7,decemb]1 #aijf71 :i* prov$ inactive physiologically1 gave an a% cont5t ( #f4i p] c5t4 ,a sample ( ,a/ragalus miss\ri5sis collect$ at ,hugo1 ,colo41 ,june1 #aijg1 yield$ an a% cont5t ( #ba4h p] c5t1 & an ,a/ragalus miss\ri5sis collect$ at ,pi]re1 ,s4 ,dak41 ,septemb]1 #aijg1 yield$ #bg p] c5t4 ,an ,a/ragalus nitidus f ,cu/]1 ,s4 ,dak4 7,july1 #aijg71 gave #e4b p] c5t a%1 :ile an ,a/ragalus nitidus collect$ at ,woodl& ,p>k1 ,colo41 9 ,octob]1 #aijf1 yield$ #g4h p] c5t1 & ano!r specim5 ( ,a/ragalus nitidus also collect$ at ,woodl& ,p>k1 ,colo41 9 ,octob]1 #aijg1 gave #ab4b p] c5t4 ,an ,a/ragalus drummondii f ,cu/]1 ,s4 ,dak4 7,july1 #aijg71 gave #e4i p] c5t4 ,a/ragalus pect9atus 7,hugo1 ,june1 #aijg7 yield$ #f4a p] c5t4 ,a fre% 7undri$7 specim5 ( ,a/ragalus mollissimus 7unkn[n orig91 ,novemb]1 #aijg7 yield$ #c4h p] c5t ( a%4 ,"o sample ( ,a/ragalus decumb5s 7,ephraim1 ,utah1 ,augu/1 #aijg7 gave #ba4h p] c5t ( a%4 ,^! det]m9ations mu/ necess>ily be only approximate1 z ! plants 7 collect$ by diff]5t p]sons :o ex]cis$ diff]5t degrees ( c>e 9 free+ !m f adh]5t soil1 & possibly 9 dry+ ! plants1 s t ! ma9 value ( ^! figures is _! aid 9 det]m9+ ! am\nt ( b>ium pres5t4 99 99 99 99 99 ,,footnotes3 #ahe ,! detail$ analysis ( ,o',br9e c be f\nd on page #cb ( ?is report4 #ahf ,all a% & b>ium det]m9ations 7 made f ! dri$ plants save :5 o!rwise specifi$4 #ahg ,evid5tly ^! plants mu/ h be5 imp]fectly fre$ f soil4 ,,b>ium ,,det]m9ations ,,9 ,,! ,,a% ,,( ,,loco ,,plants4 ,att5tion has be5 call$ to ! fact t 9 a%+ plants conta9+ b>ium a "p at lea/ ( ?is b>ium is conv]t$ into ! insoluble sulphate & a "p into ! c>bonate1 s t ! *>act]i/ic ph>macological action ( ! a% w dep5d n ^u ! total b>ium pres5t1 b ^u ! =m 9 :i* x occurs--little action if mu* ,ba,s,o#d1 & m complete if m ,ba,c,o#c results4 ,a fur!r difficulty 9 ! recognition ( b>ium 9 plants is due to ! fact t c]ta9 inorganic salts int]f]e ) ! precipitation by ,h#b,,s#d4 ,a specim5 ( ,aragallus lamb]ti 7,hugo1 summ] ( #aijg7 ) #ab4dd p] c5t ( a% 0 exam9$ = its b>ium cont5t by ,hillebr&'s me?od4#ahh ,! me?od 0 z foll[s3 ,two grams ( ! a% 7 fir/ fus$ ) sodium c>bonate & ! fus$ mass wa%$ ) wat] conta9+ sodium c>bonate4 ,! residue 0 wa%$ into a beak] & treat$ ) a few drops ( sulphuric acid4 ,! residue n[ rema9+ 0 filt]$ & aft] ignition 0 treat$ ) hydr(luoric & sulphuric acids4 ,aft] evaporat+ (f ^! acids1 ! residue 0 treat$ ) sulphuric acid wat]1 filt]$1 & !n fus$ ) sodium c>bonate4 ,aft] extract+ ) sodium c>bonate wat]1 ! residue 0 dissolv$ 9 j en\gh hydro*loric acid & precipitat$ ) sulphuric acid4 ,! precipitate 0 dissolv$ 9 conc5trat$ sulphuric acid & reprecipitat$ by wat] & weigh$ z ,ba,s,o#d4ahi ,s f> z ! writ] c asc]ta91 !re h be5 no control exp]im5ts made = ?is me?od to det]m9e ! exp]im5tal error4 ,( ! above a%1 #a4iih grams gave #e4b milligrams ( ,ba,s,o#d1 :i* w\ld correspond to #ge4ge milligrams ( b>ium acetate cry/als-- ,ba7,c#b;,h#c,o#b7b;,h#b,o--9 #bjj grams ( ! dri$ plant4 ,! residue by ! ,hillebr& me?od aft] weigh+ 0 te/$ ) ! spectroscope & gave a bright spectrum = b>ium4 ,! same a% 0 analyz$ by ! ,bureau ( ,*emi/ry1 us+ a %ort] me?od1 & !y report$ #b4g milligrams ( b>ium sulphate 9 #a4abag grams ( a%4 ,a second sample collect$ e>li] 9 ! summ]1 ) an a% cont5t ( #ah4f p] c5t1 0 %[n to yield b>ium correspond+ to #c4d milligrams ( ,ba,s,o#d 9 #b4e grams ( ! a%4#aij ,"o lot ( ,aragallus lamb]ti collect$ at ,hugo1 ,colo41 9 ,may1 #aije1 & :i* gave an a% cont5t ( #cg4c p] c5t1 0 f\nd to yield #c milligrams ( ,ba,s,o#d f #a4iih grams ( a%1 or #agc4hh milligrams ( ,ba7,c#b;,h#c,o#b7b;,h#b,o 9 #bjj grams ( ! dri$ plant1 b ?is a% also conta9$ #j4bg p] c5t ( ,,s#c4 ,! ,bureau ( ,*emi/ry report$ ! b>ium to correspond to #b4i milligrams ( ,ba,s,o#d 9 #b4de grams ( ! a%4 ,! ,a/ragalus miss\ri5sis 7,hugo1 ,june1 #aijg71 ) an a% cont5t ( #ba4h p] c5t1 gave #c milligrams ( ,ba,s,o#d 9 #b4ja grams ( a%1 or #gf4eh milligrams ( ,ba7,c#b;,h#c,o#b7b;,h#b,o 9 #bjj grams ( ! dri$ plant4 ,! residue aft] weigh+ 0 te/$ spectroscopically & gave a bright b>ium spectrum4 ,! ,a/ragalus drummondii f ,cu/]1 ,s4 ,dak4 7#aijf71 ,a/ragalus mollissimus f ,kit ,c>son ,c\nty1 ,colo4 7,decemb]1 #aijf71 & ,a/ragalus nitidus f ,woodl& ,p>k1 ,colo4 7,octob]1 #aijg71 7 report$ by ! ,bureau ( ,*emi/ry to conta9 no b>ium4 ,! a% ( ! ,a/ragalus pect9atus 7,hugo1 ,june1 #aijg7 0 report$ by ! ,bureau ( ,*emi/ry to %[ no b>ium on spectroscopic exam9ation4 ,two grams ( active loco plant a% yield$ f #e to #f milligrams ( ,ba,s,o#d1 b x c be easily se5 t 9 multiply+ ?is am\nt to correspond to #bjj grams ( ! dri$ plant errors w\ld be likely to arise1 s t ! :ole am\nt ( b>ium w\ld n necess>ily be acc\nt$ =4 99 99 99 99 99 ,,footnotes3 #ahh ,hillebr&1 ,w4 ,f4 ,analysis ( ,silicate & ,c>bonate ,rocks4 ,u4 ,s4 ,geol4 ,surv4 ,bul4 #cje1 p4 #aaf4 #aijg4 ,see also ,fol91 ,o41 ,on ! ,r$uction ( ,b>ium ,sulphate 9 ,ord9>y ,gravimetric ,det]m9ations1 9 ,j\rn4 ,biol4 ,*em41 vol4 #c1 p4 #ha4 #aijg4 #ahi ,all ! det]m9ations ( b>ium :i* result$ ei!r positively or negatively 7 made ) ! same bottle ( sodium c>bonate & ,h#b,,s#d1 s t impurities 9 ! *emicals 7 ?us elim9at$4 #aij ,report f ,bureau ( ,*emi/ry4 ,,analysis ,,( ,,soils4 ,"o sample ( ! soil f ne> ,hugo1 ,colo41 f :i* ! ,aragallus lamb]ti 0 collect$1 0 exam9$ by ! ,bureau ( ,soils1 & t ,bureau report$ ! abs5ce ( b>ium & zirconium1 at lea/ ( any recognizable by ! *emical me?ods us$1 s t x c n be said t ! b>ium came f any soil accid5tally mix$ ) ! a%4 ,traces ( titanium 71 h[ev]1 f\nd4 ,evid5tly ! plant mu/ collect m9imal quantities ( ^! elem5ts f ! soil & /ore !m4 ,! wat] f a well ( an adjac5t area 0 exam9$ by ! ,bureau ( ,*emi/ry & report$ to conta9 #cg4d p>ts ( calcium & #ac4g p>ts ( magnesium 9 "o million1 & t ! wat] conta9$ no b>ium4#aia 99 99 99 99 99 ,,footnotes3 #aia ,b>ium has be5 f\nd 9 well wat] 9 ,engl&4 ,see ,?orpe1 ,t4 ,e41 ,contribution to ! ,hi/ory ( ! ,old ,sulphur ,well1 ,h>rogate1 9 ,philos4 ,mag41 #e s41 vol4 #b1 p4 #ej1 #ahgf4 ,,fe$+ ,,exp]im5ts ,,) ,,b>ium ,,salts ,,on ,,animals ,,9 ,,! ,,laboratory4 ,on ^! figures ! writ] took #j4b gram ( cry/alliz$ b>ium acetate c4 p41 us+ ! acetate because acetic acid has be5 prov$ 9 c]ta9 loco plants by ,p[] & ,cambi]1 & aft] dissolv+ x 9 wat] f$ x at #i4de a4m4 to a rabbit weigh+ #a1agg grams4 ,! head soon fell =w>d s t ! nose re/$ on ! gr\nd4 ,at #aj4eh a4m4 ! rabbit seem$ unable to guide itself & w\ld run into ob/ructions if =c$ to move4 ,!re 0 no di>rhea b x ur9at$ sev]al times4 ,!re 0 a peculi> tremor ( ! muscles not$4 ,! animal w\ld n />tle by sudd5 noises & at #aa4jf a4m4 c\ld be plac$ on its back ) ease4 ,! pupils appe>$ ab\t normal4 ,! :ites ( ! eyes %[$ v prom95tly4 ,at #aa4ce a4m4 ! =e legs 7 p>alyz$4 ,! foll[+ morn+ ! animal 0 dead1 its weight be+ #a1abj grams4 ,! he>t 0 dilat$2 ! /oma* 0 n hemorrhagic1 b r pale4 ,a second rabbit1 :i* weigh$ #a1fcj grams1 0 f$ ) a solution ( #j4e gram ( ! same salt at #i4db a4m4 ,at #aj4ce a4m4 ! animal pass$ s(t /ools & %[$ a m>k$ dis9cl9ation to move1 ) evid5ce ( pa94 ,! di>rhea#aib became m m>k$ & ! animal's h9d qu>t]s 7 soil$ ) feces4 ,at #aj4dh a4m4 !re 0 m>k$ incoord9ation ( ! limbs & inability to /&4 ,f9ally1 at #aj4ef a4 m41 convulsions began & ! animal di$ at #aa4jb a4m4 ,! autopsy 0 made ab\t two h\rs lat]4 ,! animal 0 !n rigid4 ,! kidneys seem$ r conge/$4 ,! inte/9es 7 relax$2 mes5t]ic vessels dilat$4 ,! pyloric region ( ! /oma* appe>$ hemorrhagic4 ,a ?ird rabbit1 f$ l ! prec$+ ) #j4e gram ( b>ium acetate1 %[$ mu* ! same result4 ,9 ?is case !re 0 "s ret*+1 b ! o!r symptoms 7 z above1 ! animal dy+ 9 "o h\r & five m9utes4 ,no hemorrhages 7 se5 9 ! /oma* walls4 ,x 0 not$ t aft] ! adm9i/ration ( c]ta9 doses1 #j4b gram1 !re 0 no di>rhea4 ,on ,septemb] #bc1 #aijg1 a rabbit weigh+ #a1geg grams 0 f$ at #aj4db a4 m4 ) #j4a gram ( ! same b>ium acetate4 ,! temp]ature at ! "t ( fe$+ 0 #ajb4i;,f4 ,at #ab4je a4m4 ! animal ur9at$4 ,temp]ature1 #aja4d;,f4 ,on ,septemb] #bd ! animal weigh$ ! same4 ,temp]ature at #aj4ee a4m41 #ajb4c;,f4 ,! same am\nt ( b>ium 0 f$4 ,at #c4dj p4m4 ! temp]ature 0 #ajb4e;,f4 ,on ,septemb] #be ! animal weigh$ #a1hjj grams4 ,temp]ature1 #ajb4b;,f4 at #aj4ci a4m4 ,! dose ( b>ium 0 repeat$4 ,at #c4ee p4m4 ! temp]ature 0 #aja4d;,f4 ,on ,septemb] #bf at #i4ch a4m4 ! temp]ature 0 #aja4a;,f41 & aga9 ! b>ium 0 giv54 ,at #c4eg p4m4 ! temp]ature 0 #aja4e;,f4 ,on ,septemb] #bg ! rabbit weigh$ #a1ggb grams4 ,! temp]ature at #i4ec a4 m4 0 #ajb4c;,f4 ,! b>ium 0 f$ = ! fif? "t4 ,at #aj4bg a4m4 !re 7 g5]al convulsions4 ,! eyes te>$4 ,at #aj4cb a4m4 s(t /ools appe>$ & ! animal ur9at$4 ,/ools 7 pass$ at v>i\s p]iods4 ,at #aa4cj a4m4 !re 7 no signs ( pa9 on p9*+ ! e>4 ,at #aa4eh a4m4 ! animal ret*$4 ,! animal 0 ly+ ) ! =e legs wide ap>t & c\ld n support itself4 ,at #ab4je p4m4 ! temp]ature 0 #ih;,f4 & ! rabbit di$ %ortly aft]4 ,! p]itoneal cavity seem$ normal4 ,! small inte/9es 7 relax$1 :ile ! mes5t]ic vessels 7 dilat$4 ,! kidneys seem$ conge/$4 ,! /oma* walls 7 p9k & 9 places cov]$ ) mucus4 ,! he>t 0 relax$ save ! left v5tricle1 :i* seem$ firm4 ,on ,septemb] #bc1 #aijg1 a second rabbit1 weigh+ #a1cfj grams1 0 f$ ) a simil> solution & ! fe$+ 0 repeat$ at ! same "t ! fir/ rabbit 0 f$4 ,on ,septemb] #bg ! animal weigh$ #a1daf grams4 ,on ?is day a peculi> movem5t ( ! h9d legs on jump+ appe>$1 app>5tly due to an inability to draw ! legs completely up1 & ! =e legs 7 spread wide ap>t1 z if too weak to support ! animal4 ,! temp]ature _h also fall54 ,on ,septemb] #bh ! animal _h app>5tly recov]$4 ,weight1 #a1eaf grams on ,octob] #ba4 ,on ,septemb] #bc1 #aijg1 a ?ird rabbit1 weigh+ #a1cjd grams1 0 f$ ) #ej milligrams ( b>ium acetate4 ,?is dose 0 repeat$ ea* "t ! o!r two rabbits 7 f$4 ,on ,septemb] #bg x weigh$ #a1cjd grams4 ,m>k$ muscul> twit*+ appe>$1 ) dis9cl9ation to move4 ,f9ally !re 7 convulsions & p>alysis ( ! limbs4 ,no /ools 7 se54 ,?is animal lay quiet all night1 app>5tly unable to move1 & cont9u$ on its side until #c4ae p4m4 on ,septemb] #bh1 :5 x gradually recov]$1 weigh+ #a1cdf grams on ,octob] #bd4 ,on ,octob] #bd1 #aijg1 a rabbit weigh+ #a1cdf4e grams 0 f$ ) a solution ( #be milligrams ( cry/alliz$ b>ium acetate4 ,on ! next day ! weight 0 #a1cah grams1 & ! dose 0 repeat$4 ,on ,octob] #bf x weigh$ #a1bge4g grams1 & ! dose 0 repeat$2 on ,octob] #cj x weigh$ #a1ccb grams1 & on ,octob] #ca its weight 0 #a1cge grams4 ,! animal di$ at night on ,novemb] #f2 weight1 #a1acd grams4 ,! po/-mortem exam9ation1 made ) ,dr4 ,meade ,bolton1 ( ! ,bureau ( ,animal ,indu/ry1 0 negative save = ! pres5ce ( necrotic tissue 9 "o enl>g$ ?yroid4 ,on ,octob] #bd1 #aijg1 a rabbit weigh+ #a1ccb grams 0 f$ ) a solution ( #be milligrams ( cry/alliz$ b>ium acetate4 ,on ! next day ! animal weigh$ ! same1 & ! dose 0 repeat$4 ,on ,octob] #bf x weigh$ #a1bhi grams1 & ! same am\nt ( b>ium 0 giv54 ,on ,octob] #bh ! weight 0 #a1bai grams & two days lat] #a1bhi grams4 ,on ,octob] #ca1 #aijg1 a rabbit weigh+ #gbc grams 0 f$ ) a solution ( #be milligrams ( b>ium acetate4 ,?is rabbit 0 f$ 9 all n9e times dur+ a p]iod ( t5 days4 ,at ! end ( ?is "t x weigh$ #ggi grams & di$ six days lat]1 weigh+ #gbc grams4 ,! po/-mortem 0 negative4 ,a rabbit weigh+ #ggi grams 0 also f$ on ,octob] #ca1 #aijg1 ) a simil> am\nt ( b>ium4 ,?is dose 0 repeat$ six times dur+ an int]val ( eight days4 ,at ! end ( t "t ! animal /ill reta9$ its normal weight4 ,on ,novemb] #ad1 #aijg1 x weigh$ #gji grams1 hav+ lo/ #gj grams4 ,?us aft] daily doses ( #j4a gram ( cry/alliz$ b>ium acetate no symptoms appe>$ until ! fif? day1 :5 dea? result$4 ,aft] ! simil> adm9i/ration ( #ej milligrams sev]e symptoms develop$ on ! same day1 b ! animal recov]$4 ,aft] ! adm9i/ration ( #be milligrams on ?ree successive days ! animal di$4 ,9 o!r cases ( fe$+ #be milligrams = sev]al successive days1 "s lo/ weight & di$2 o!rs m]ely lo/ 9 weight1 b recov]$4 ,b>y f$ a rabbit weigh+ #j4i kilogram a solution ( #cj milligrams ( b>ium *lorid on "o day1 on ! second day #ij milligrams1 & on ! ?ird day #cj milligrams4 ,! only symptom not$ 0 di>rhea4 ,! animal di$ on ! fif? day4 ,9 o!r words1 aft] fe$+ small doses ( b>ium salts = sev]al days acute symptoms sudd5ly set 91 %[+ a cumulative action4 ,?is cumulative action has be5 not$ on man4#aic ,onsum#aid f$ a m$ium-siz$ rabbit daily ) small doses ( b>ium c>bonate1 beg9n+ ) #bj milligrams4 ,:5 ! total am\nt rea*$ #j4ai grams ! rabbit di$4 ,! animal be=e dea? %[$ p>alysis1 respiratory di/urbances1 & fall 9 temp]ature4 ,! s5sibility ( ! cornea dim9i%$1 b ! pupils respond$ to light4 ,! /oma* walls %[$ ec*ymoses & ! blood vessels ( ! bra91 ! sp9al cord1 & ! abdom9al vessels 7 dilat$4 ,emboli 9 ! pulmon>y art]ies 7 also not$4 ,9 a rabbit ! application ( #j4ff gram ( b>ium *lorid to a w\nd 0 foll[$ 9 tw5ty m9utes by convulsions1 p>alysis1 & f9ally coma & dea?4#aie ,( b>ium nitrate #j4ff gram mix$ ) sug> & f$ to a rabbit caus$ dea? 9 less ?an "o h\r1 & #j4cc gram induc$ dea? 9 ano!r rabbit 9 tw5ty-sev5 h\rs4#aif ,six gra9s 7#j4d gram7 ( b>ium iodid f$ 9 solution to a rabbit caus$ dea? ! foll[+ day4 ,on ?is day !re 7 tremors ( ! neck & %\ld]s ) convulsive movem5ts ( ! limbs4 ,!re 0 also gr9d+ ( ! tee?4 ,! muc\s membrane ( ! /oma* 0 rose-r$ at ! c>dia1 & s(t5$4 ,membranes ( ! cord & bra9 also 7 conge/$4#aig ,= rabbits weigh+ #a1ejj to #b1jjj grams ! le?al dose ( b>ium *lorid on subcutane\s use is /at$ to be #j4je to #j4jf grams4#aih ,a rabbit weigh+ #a1ajf grams 0 f$ ) a solution conta9+ #ej milligrams ( cry/alliz$ b>ium acetate c4 p4 & #ej milligrams ( zirconium *lorid 7pure74 ,9 fifty-sev5 m9utes ! animal %[$ difficulty 9 mov+ ! =e legs1 develop+ m>k$ p>alysis ( ! same ab\t five h\rs lat]1 & di$ ! foll[+ morn+--t is1 tw5ty-two h\rs aft] fe$+4 ,! he>t 0 f\nd dilat$1 kidneys conge/$1 /oma* walls p9k & cov]$ 9 places ) mucus & p>tly dige/$ blood1 & c]ebral dural vessels dilat$1 b no clots 7 se52 bladd] full4 ,mixtures ( #j4e gram ( calcium acetate & #ej milligrams ( b>ium acetate fail$ to kill4 ,mixtures ( titanium & b>ium 7 n tri$1 z no titanium salt soluble 9 wat] & ( neutral reaction 0 accessible4 ,mittel/a$t call$ att5tion to ! fact t pregnant rabbits 7 m easily affect$ by ! b>ium adm9i/ration ?an nonpregnant ones1 & not$ abortion 9 "o case4#aii ,"o gram ( ! b>ium c>bonate kill$ a dog 9 eight h\rs4 ,a second dog di$ 9 fifte5 h\rs4 ,bo? ( ^! animals vomit$ s t a portion ( ?is mu/ h be5 lo/4#bjj ,b>ium c>bonate 0 =m]ly employ$ z a rat poison4#bja ,( b>ium *lorid #j4f gram1 f$ 9 aque\s solution1 caus$ dea? 9 a dog 9 =ty-eight m9utes if vomit+ 0 prev5t$4#bjb ,9 ,tidy's h&s #b grams ( ! b>ium nitrate caus$ dea? 9 a small t]ri] 9 ?ree & ?ree-f\r? h\rs4 ,?is dog _h slight convulsions1 0 almo/ unable to /&1 & _h vomit+ & purg+4 ,! reflexes 7 dim9i%$4 ,a small dog recov]$ only completely 9 five days aft] be+ f$ #j4ff gram1 :ile a l>ge dog aft] be+ f$ #a4c grams only recov]$ aft] two days4 ,9 cats #j4h gram ( b>ium c>bonate :5 introduc$ into a w\nd caus$ on ! ?ird day languor1 sl[ respiration1 feeble pulse1 twit*+ ( h9d legs1 dilat$ pupils1 & dea?4#bjc 99 99 99 99 99 ,,footnotes3 #aib ,magnus1 ,r4 ,wirkungsweise u4 ,angriffspunkt e9ig] ,gifte am ,katz5d>m4 ,ar*iv4 f4 ,gesam4 ,physiol41 vol4 #ajh1 p4 #dd1 #aije4 ,,note4--,reports on ! hi/ological *anges 9 acute b>ium poison+ c be f\nd 9 ,pilliet1 ,a41 & ,malbec1 ,a4 ,note sur les ,lesions ,hi/ologiques du ,re9 ,produits p> les ,sels de ,b>yte sur les ,animaux4 ,comp4 ,r5d4 ,hebd4 ,soc4 de ,biol41 vol4 #d1 p4 #ieg4 #ahib4 ,lit]ature on ! ph>macology ( b>ium n o!rwise ref]r$ to is z foll[s3 ,boehm1 ,r4 ,ueb] d4 ,wirkung5 d4 ,b>ytsalze auf d4 ,?i]krp]4 ,ar*4 f4 ,exp4 ,pa?41 vol4 #c1 p4 #bag4 #ahge4--,somm]1 ,f4 ,beitr4 z4 ,k5nt4 d4 ,b>yum-,v]giftung4 ,diss]t41 ,wrzburg1 #ahij4--,neumann1 ,j4 ,ueb] d5 ,v]bleib d] 9 d5 ?i]is*5 ,organismus e+efhrt5 ,b>iumsalz54 ,ar*iv4 f4 ,gesam4 ,physiol41 vol4 #cf1 p4 #egf4 #ahhe4--;,hefftn]1 ,a4 ,auss*eidung krp]fremd] ,sub/anz5 im ,h>n1 ,ergeb4 d4 ,physiol41 pt4 #a1 p4 #aba4 #aijc4--;,b9et1 ,p4 ,re*]*es ,comp>4 sur l',action ,physiol4 des ,mtaux1 ,alcal9s et ,alcal9o-t]reux4 ,rev4 ,md4 de la ,suisse ,rom&e1 vol4 #ab1 pp4 #ece1 #fjg4 #ahib4--;,cyon1 ,m4 ,ueb] d4 toxis*4 ,wirkung4 d4 ,b>yt u4 ,oxalsurev]b9dung54 ,ar*iv4 f4 ,anat41 ,physiol4 u4 ,wiss5s4 ,m$41 #ahff1 p4 #aif4--,mickwitz1 ,l4 ,v]glei*4 ,unt]su*4 4 d4 ,physiol4 ,wirkung d4 ,salze d4 ,alcali5 u4 ,alcal4 ,erd54 ,diss]t41 ,dorpat1 #ahgd4--;,heilborn1 ,f4 ,ueb] ,v]nd]ung5 im ,d>me na* ,v]gift4 mit ,ars51 ,*lorb>ium und ,phosphor4 ,diss]t41 ,wrzburg1 #ahia4--,re9cke1 ,j4 ,j4 ,e9 ,fall mehrfa*] ,v]giftung dur* kohl5sur5 ,b>yt4 ,vi]telj4 f4 g]i*tl4 ,m$41 n4 s41 vol4 #bh1 p4 #bdh4 #ahgh4--,orfila1 ,mmoire sur l',empoisonnem5t p> les ,alcalis ,fixes4 ,j\rn4 de ,*imie ,md41 #b s41 vol4 #h4 p4 #bjj4 #ahdb4--,santi1 ,l4 ,se nel ,v5eficio p] ,sali di ,b>io que/o ,metallo passa alla ,ur9a8 ,gazz4 ,*em4 ,ital41 vol4 #cc1 pt4 #b1 p4 #bjb4 #aijc4--,web]1 ,f4 ,r4 ,b>ium ,*loride4 ,milwaukee ,m$4 ,j\rn41 vol4 #ab1 pp4 #ci1 #fj4 #aijd4--,rabuteau4 ,de l',innocuit des ,sels de ,/rontium ,comp>e l',activit du ,*lorure de ,b>yum4 ,gaz4 ,md4 de ,p>is1 #c s41 vol4 #bd1 p4 #bah4 #ahfi4--,! v e>ly lit]ature is consid]$ 9 detail by ,b>y4 #aic ,b>y1 ,a4 ,beitr4 z4 ,b>yumwirkung4 ,diss]t41 ,dorpat1 #ahhh1 p4 #ajj4 #aid ,onsum1 ,j4 ,ueb] d4 toxis*4 ,wirkung4 d] ,b>yt und ,oxalsurev]b9dung54 ,ar*4 f4 ,pa?4 ,anat41 vol4 #bh1 p4 #bcd4 #ahfc4 #aie ,brodie1 ,b4 ,c4 ,fur!r ,exp]im5ts & ,obs]vations on ! ,action ( ,poisons on ! ,animal ,sy/em4 ,philos4 ,trans41 vol4 #ajb1 p4 #bah4 #ahab4 #aif ,tidy1 ,c4 ,m4 ,on ,poison+ by ,nitrate ( ,b>yta4 ,m$4 ,press & ,circ41 vol4 #f1 p4 #ddh4 #ahfh4 #aig ,glov]1 ,r4 ,m4 ,on ! ,physiological & ,m$ic9al ,prop]ties ( ,brom9e & ,its ,comp\nds4 ,ed9b4 ,m$4 ,surg4 ,j\rn41 vol4 #eh1 p4 #cda4 #ahdb4 #aih ,kissn]1 ,g4 ,ueb] ,b>yum ,v]giftung5 u4 d]5 ,e9fluss auf d4 ,glykog5gehalt d] ,leb]4 ,s*olt51 #ahif1 p4 #aa4 #aii ,mittel/a$t1 ,f4 ,ueb] *ronis*e ,b>iumv]giftung4 ,diss]t41 ,greifswald1 #ahie1 p4 #ai4 #bjj ,pelleti]1 ,d4 ,obs]vations sur la ,/rontiane4 ,annal4 de ,*imie1 vol4 #ba1 p4 #aai4 #agig4 #bja ,*ri/ison1 ,r4 ,treatise on ,poisons4 ,ed9burgh1 #ahde1 p4 #egi4--;,crampe4 ,bewhrte ,mittel geg5 ,feldmuse4 ,deuts*4 ,l&w4 ,presse1 vol4 #e1 p4 #ecj4 #ahgh4--;,fellet>1 ,e4 ,flle von ,intox4 mit kohl5sur4 ,b>yum4 ,pe/4 ,m$4-,*ir4 ,presse1 vol4 #bh1 p4 #ajgb4 #ahib4 #bjb ,husemann1 ,t4 ,e9 ,beitrag z4 ,k5nt4 d4 ,b>ytv]giftung54 ,zeits4 f4 pract4 ,heilk41 vol4 #c1 p4 #bce4 #ahff4 ,9 ?is article ,husemann has collect$ _m cases ( poison+ by b>ium 9 animals4 #bjc ,*ri/ison1 ,r4 ,treatise on ,poisons4 ,ed9burgh1 #ahde1 p4 #egi4 ,,b>ium ,,poison+ ,,9 ,,man4 ,! high toxicity ( b>ium 0 call$ att5tion to by e>ly obs]v]s1 b x 0 attribut$ by "s to admix$ ars5ic4 ,! reports ( fe$+ exp]im5ts ) b>ium on animals h v>i$ m>k$ly1 b n[ c>e is be+ advis$ 9 ! use ( b>ium salts4#bjd ,b>ium 0 introduc$ into m$ic9e 9 ! treatm5t ( scr(ula1 b has fall5 into disuse1 & only rec5tly att5tion has be5 call$ to x on acc\nt ( its action on ! circulatory sy/em4 ,filippi1#bje h[ev]1 says1 ,! effects on ! he>t & on ! pressure are already ! fir/ indication ( poison+4 ,?is metal has also be5 us$ 9 ! treatm5t ( *ronic diseases ( ! sp9al cord1 z multiple scl]osis & p>alysis agitans4#bjf ,aft] ! adm9i/ration to a woman ( #a_/ab gra9 7#j4jje gram7 ( b>ium *lorid ?ree to five times a day = a few days1 a total ( #b-a_/d gra9s 7#j4ace gram71 ! pati5t develop$ rapid respiration1 t5d]ness ov] ! epiga/rium1 nausea1 con/ipation1 cramps 9 ! limbs1 loss ( appetite1 weakness1 great emaciation1 dysuria1 "s deafness ) t9nitus1 difficulty 9 speak+ & ?9k+1 ) v]tigo4#bjg ,9 ?is case ! eyes 7 glassy1 ! vision indi/9ct1 & ! *eeks flu%$4 ,kohl aft] ! use ( small doses ( ! same not$ salivation1 swell+ ( ! gums1 & fall+ out ( ! tee?1 ) a m]curial odor to ! brea?4 ,*ri/ison#bjh /ates3 ,i h kn[n viol5t vomit+1 gripes1 & di>rhea produc$ 9 l mann] by a quantity n exce$+ ! usual m$ic9al doses4 ,accord+ to ,k5n$y few p]sons are able to be> #a_/h gra9 7#j4jjge gram7 ( b>ium *lorid4#bji ,9 ,c>p5t]'s case aft] ?ree doses ( #a4f gra9s 7#j4jgj gram7 ( b>ium *lorid ! pati5t develop$ almo/ le?al symptoms4#baj ,c>p5t] calls att5tion to ! dr[s9ess :i* develop$ 9 ?is pati5t aft] ! adm9i/ration ( b>ium1 a fact :i* _h already be5 not$ by ,*ri/ison4#baa ,a c>t>rhal affection ( v>i\s muc\s membranes & a swell+ ( v>i\s gl&s h be5 not$1 especially ( ! lymph & saliv>y gl&s1 & 9 ! male ! te/es h at times swoll54#bab ,! inflammation ( ! gl&s may pass on to suppuration4 ,! sk9 becomes dry & %[s a t5d5cy to crack4 ,febrile attacks are report$ aft] ! repeat$ use ( small doses ( b>ium4 ,s*eibl]#bac has call$ att5tion to ! possibility ( produc+ *ronic b>ium poison+ 9 man f ! use ( b>ium 9 ! manufacture ( food products4 ,acute cases ( poison+ 9 man f f\r or m grams ( b>ium c>bonate or *lorid or nitrate h be5 report$ m or less frequ5tly4#bad ,9 ! acute case ( poison+ 9 man report$ by ,tirabos*i & ,taito1 no macroscopic *anges 7 not$ 9 ! /oma* mucosa4#bae ,lopes#baf has report$ "o case ( acute poison+ 9 man f less ?an #a gram ( b>ium *lorid4 ,9 ?is case p>alysis ( ! limbs 0 a m>k$ feature4 ,/]n#bag cites ,p]ondi & ,lisfranc to ! effect t rem>kably l>ge doses ( b>ium *lorid c be borne )\t injury by gradually increas+ ! doses 7dissolv$ 9 mu* wat]74 ,lisfranc#bah has sugge/$ t ! s5sitiv5ess to poison+ by b>ium salts is great] 9 c]ta9 climates ?an 9 o!rs4 ,no data are z yet available z to ! influ5ce ( altitude & p>tial />vation on ! toxicity ( b>ium salts4 ,z is well kn[n1 almo/ all record$ cases ( loco$ animals h occurr$ at a high altitude4 ,x mu/ also be rememb]$ t ! addition ( "o salt to ! solution ( ano!r may greatly increase ! toxicity ( ! fir/ "o4 ,?us1 ! addition ( a few milligrams ( b>ium *lorid to a solution ( a sulphocyanate r5d]s ! latt] mu* m poison\s4#bai ,?is may be due to ! fact t ! salts are m completely ioniz$4 99 99 99 99 99 ,,footnotes3 #bjd ,accord+ to v4 ,jaks*1 ,sie i/ bei d] gross5 ,toxicitt d] ,sub/anz imm] ern/ zu /ell54 ,v]giftung51 #ahig1 p4 #gi4 ,,note4--,a ?or\gh ph>macological /udy ( "s b>ium salt is mu* ne$$1 & x is hop$ t ! writ] w be able to complete ?is "w4 #bje ,filippi1 ,e4 ,modificaz4 del ,ricambio ,organice p] ,azione del ,cloruro di ,b>io4 ,la ,sp]im5tale1 vol4 #fj1 p4 #faj4 #aijf2 ,sull' ,azione ,c>diaca del ,*loruro di ,b>io4 ,ar*ivio di ,f>macol4 ,sp]im5t41 vol4 #e1 p4 #abb4 #aijf4 #bjf ,s*ulz1 ,h4 ,vorles4 4 ,wirkung4 u4 ,anw5dung d4 unorganis*4 ,arznei/(fe4 ,leipzig1 #aijg1 p4 #bcd4--;,h>e1 ,h4 ,a4 ,use ( ,b>ium ,*loride 9 ,he>t ,disease4 ,m$4 ,news1 vol4 #ed1 p4 #ahc4 #ahhi4 #bjg ,f]guson1 ,j4 ,c4 ,symptoms ( ,poison+ f ,muriate ( ,b>ytes4 ,dubl9 ,qu>t4 ,j\rn4 ,m$4 ,sci41 vol4 #a1 p4 #bga4 #ahdf4 #bjh ,*ri/ison1 ,r41 l4 c41 p4 #ehj4 #bji ,k5n$y1 ,h4 ,dose ( ! ,muriate ( ,b>ytes4 ,lancet1 vol4 #b1 p4 #bh4 #ahgc4 #baj ,c>p5t]1 ,j4 ,s4 ,b>ium ,*oride f a ,cl9ical ,/&po9t4 ,m$4 ,news1 vol4 #ei1 p4 #ic4 #ahia4 #baa ,*ri/ison1 ,r41 l4 c41 #ahde1 p4 #egh4 #bab ,s*ulz1 ,h4 ,vorles4 4 ,wirkung4 u4 ,anw5dung d4 unorganis*4 ,arznei/(fe4 ,leipzig1 #aijg1 p4 #bcc4--,s*wilgu1 ,c4 ,j4 ,a4 ,trait de ,mat4 ,md41 #c ed41 vol4 #a1 p4 #dda4 #ahah4 ,,note4--,accord+ to ! files ( ! ,(fice ( ,poison\s-,plant ,inve/igations1 ,e4 ,d4 ,smi? report$ 9 ! ,orange ,judd ,f>m]1 #ahig1 t loco$ animals %[$ a swell+ ( v>i\s gl&s4 ,z yet ! writ] has be5 unable to v]ify ?is ref]5ce4 #bac ,s*eibl]1 ,c4 ,ueb] d4 ,v]w5dung giftig] ,/(fe1 besond]s d4 ,b>ytv]b9dung5 bei d4 ,zuck]fabrication4 ,*em4 ,zeit41 vol4 #aa1 p4 #adfc4 #ahhg4 #bad ,s*midt's ,jahrb*]1 vol4 #aib1 p4 #aca4 #ahha4--,wal%1 ,j4 ,report ( a ,case ( ,poison+ by ,*loride ( ,b>ium4 ,lancet1 vol4 #a1 p4 #baa4 #ahei4--,wal*4 ,selt5] ,fall e9] tdli*4 ,v]giftung d4 ,b>yta muriatica4 ,zeits4 f4 ,/aats>znk41 vol4 #cj1 p4 #a4 #ahce4--;,c>p5t]1 ,j4 ,s4 ,b>ium ,*loride f a ,cl9ical ,/&po9t4 ,m$4 ,news1 vol4 #ei1 p4 #ic4 #ahia4--;,es*ri*t4 ,ddeligt =lb5de ,=giftn+ m$ salpet]surt ,b>yt4 ,ugeskrift = ,laeg]1 vol4 #d1 p4 #bda4 #ahha4--,ogl] & ,socquet4 ,empoisonnem5t p> le ,*lorure de ,b>yum4 ,annal4 d',hyg4 ,publ41 #c s41 vol4 #be1 p4 #ddg4 #ahia4--;,*evalli]1 ,a4 ,note sur un ,cas d',empoisonnem5t ,dt]m9 p> l',actate de ,b>yte4 ,annal4 d',hyg4 ,publ41 #b s41 vol4 #ci1 p4 #cie4 #ahgc4--;,c\rt91 ,cas d',empoisonnem5t p> du ,*lorure de ,b>yum4 ,rev4 d',hyg41 vol4 #d1 p4 #fec4 #ahhb4--,poison+ by a ,b>yta ,comp\nd4 ,ph>m4 ,j\rn41 #c s41 vol4 #b1 p4 #ajba4 #ahgb4--,rei*>dt1 ,e4 ,v]giftungsfall mit kohl5surem ,b>yt4 ,ar*4 d4 ,ph>m41 #c s41 vol4 #d1 p4 #dbf4 #ahgd4--,lag>de1 ,p4 ,actate de ,b>yte livr s\s le ,nom de ,sulfov9ate de ,s\de4 ,union ,md41 #c s41 vol4 #ad1 p4 #ecg4 #ahgb4--;,baum4 ,zwei ,flle von fahrlssig] ,tdtung dur* saltpet]sures ,b>yt4 ,zeits4 f4 ,m$iz9albeamte1 vol4 #i1 p4 #gei4 #ahif4--;,fun>o1 ,a4 ,sul ,v5eficio p] ,sali di ,b>io4 ,l',orosi1 vol4 #ab1 p4 #cig4 #ahid4 #bae ,tirabos*i1 ,a41 & ,taito1 ,f4 ,avvel5am5to da ,b>io4 ,il ,risveglio ,m$ico d',abruzzo e ,molise1 vol4 #a1 p4 #aga4 #aijf4 ,,note4--,a criticism ( ?is case is to be f\nd 9 ,bellis>i1 ,g41 ,su ,di un ,presunto ,avvel5am5to da ,b>io4 ,il ,risveglio ,m$ico d',abbruzzo e ,molise1 vol4 #b1 p4 #ae4 #aijg4 #baf ,lopes1 ,a4 ,caso ,curioso de ,env55am5to ,pelo ,*loret de ,b>io4 ,m$ic9a ,contempt41 ,lisbon1 vol4 #d1 p4 #aji4 #ahhf4 #bag ,/]n1 ,e4 ,v]giftung mit ,*lorb>ium4 ,zeits4 f4 ,m$iz9albeamte1 vol4 #i1 p4 #chc4 #ahif4 ,,note4--,! writ] has always !oretically que/ion$ ! dang] ( poison+ by loco we$s 9 well-f$ & well-wat]$ animals4 ,comp>e ,/alk]1 ,m41 ,! ,loco ,plant & ,its ,effect on ,animals4 ,bur4 ,animal ,indu/ry1 #c;d ,ann4 ,report 7#ahhf71 p4 #bga4 #ahhg4 #bah ,lisfranc4 ,leon sur l',emploi du ,muriate de ,b>yte contre les ,tumeurs ,blan*es4 ,gaz4 ,md4 de ,p>is1 #b s41 vol4 #d1 p4 #bae4 #ahcf4 #bai ,pauli1 ,w41 & ,frhli*1 ,a4 ,ph>makodynam4 ,/udi54 ,sitz4 ,kais]l4 ,acad4 d4 ,wiss5s4 z4 ,wi51 vol4 #aae1 ,,iii1 pt4 #f1 p4 #dde4 #aijf4 ,,pa?ological ,,lesions ,,9 ,,exp]im5tal ,,b>ium ,,poison+4 ,! po/-mortem exam9ations 9 cases ( acute exp]im5tal b>ium poison+1 accord+ to ,s*$el1#bbj %[ puncti=m or l>ge hemorrhagic effusion 9 ! fundus v5triculi#bba & 9 ! l>ge & small inte/9es1 contraction ( ! bladd]1 & hemorrhage into ! walls ( ! bladd] & ut]us4 ,! he>t is usually f\nd relax$ or ! left v5tricle contract$ 9 sy/ole1 :ile ! "r is relax$4 ,only once 7 ec*ymoses "u ! endoc>dium se54 ,! liv] & kidneys %[$ no?+ special4 ,! ur9e 0 free f album5 & sug>4 ,9 a few cases ! lungs %[$ "s infiltration ) blood4 ,9 *ronic cases1 accord+ to our own inve/igations 9 rabbits1 !re are no *>act]i/ic macroscopic lesions1 a result :i* agrees ) ,mittel/a$t's report4#bbb ,no?nagel & ,rossba*#bbc claim t 9 *ronic poison+ by b>ium ! p]iph]al n]ves are alt]$4 ,! same negative results h also be5 report$ 9 *ronic poison+ 9 high] animals4 ,reynolds#bbd not$ a lay] l a blood clot "u ! c]ebellum 9 a horse f$ ) b>ium *lorid4 ,fu*s#bbe has call$ att5tion to ! fact t ! fle% ( cattle poison$ ) b>ium *lorid 0 h>mless1 p]haps ow+ to a conv]sion into an insoluble salt1 a fact :i* may be consid]$ 9 ! use ( loco$ animals = food4 99 99 99 99 99 ,,footnotes3 #bbj ,s*$el1 ,h4 ,beitr4 z4 ,k5nt4 d4 ,wirkung des ,*lorb>iums4 #aijc1 p4 #ac4 #bba ,aft] subcutane\s injection ( b>ium *lorid1 ,lew91 by means ( ! spectroscope1 has f\nd b>ium 9 ! /oma* walls4 ,lew91 ,l4 ,s*icksal krp]fremd] *em4 ,/(fe im ,m5s*5 u4 besond]s ihre ,auss*eidung4 ,deuts*4 ,m$4 ,wo*41 vol4 #cb1 p4 #agc4 #aijf4 #bbb ,mittel/a$t1 ,f4 ,ueb] *ronis*e ,b>iumv]giftung4 ,diss]t41 ,greifswald1 #ahie1 p4 #bi4 #bbc ,no?nagel1 ,h41 & ,rossba*1 ,m4 ,j4 ,h&b4 d4 ,arzneimittel1 p4 #ha4 #aijd4 #bbd ,reynolds1 ,m4 ,h4 ,a ,/udy ( ,c]ta9 ,ca?>tics4 ,m9n4 ,agric4 ,exp]4 ,/a41 #ae? ,ann4 ,rept4 #aijg4 #bbe ,fu*s1 ,c4 ,j4 ,v]giftungsflle dur* salzsur5 ,b>yt beim ,r9dvieh4 ,?i]rztl4 ,mit!il41 vol4 #e1 p4 #aei4 #ahgj4 ,fu*s sugge/s t fur!r inve/igations on ?is po9t are desirable4 ,! lit]ature ( ?is class ( exp]im5ts is v scanty4 ,see ,frhn] & ,knuds51 ,e9ige ,v]su*e b] d4 ,g5iessb>keit d4 ,fleis*es v]gift4 ,?i]e4 ,monats4 f4 ,prakt4 ,?i]heilk41 vol4 #a1 p4 #ebi4 #ahij4 ,,toxicity ,,( ,,v>i\s ,,aque\s ,,extracts ,,( ,,loco ,,plants4 ,on ,octob] #ba1 #aijg1 a rabbit weigh+ #a1eca grams 0 f$ ) an extract ( #ie grams ( dri$ ,aragallus lamb]ti 7,hugo1 ,colo41 #aijg71 ) an a% cont5t ( #ab4dd p] c5t1 ) a b>ium cont5t e/imat$ z #b4f milligrams ( ,ba,s,o#d 9 #a gram ( a%4 ,on ! foll[+ day x weigh$ #a1eag grams1 & ! same dose 0 aga9 adm9i/]$4 ,on ,octob] #bc ! weight 0 #a1dhh grams1 & ! dose 0 repeat$4 ,on ! next day ! weight 0 ! same & ! dose 0 repeat$4 ,on ,octob] #bf ! weight 0 #a1ddf grams1 & aga9 ! same extract 0 giv54 ,on ,octob] #cj ! animal weigh$ #a1ejb4e grams2 on ,octob] #ca1 #a1eca grams4 ,! animal receiv$ a total extract ( #dge grams ( ! dri$ plant )\t s]i\s injury4 ,?is result 0 app>5tly contradictory to ! e>li] "w4 ,on ,octob] #ba1 #aijg1 a rabbit weigh+ #a1gdc grams 0 f$ ) an extract ( #dg4e grams ( ! same dri$ plant4 ,on ! next day its weight 0 #a1gbi grams1 & ! same am\nt ( ! extract 0 f$4 ,on ,octob] #bc ! weight rema9$ ! same1 & ! dose 0 repeat$4 ,on ,octob] #bd ! weight 0 #a1feh grams1 & ! same am\nt ( extract 0 f$4 ,on ,octob] #bf ! animal weigh$ #a1fcj grams1 :5 x 0 aga9 f$ ) ! same am\nt ( extract4 ,on ,octob] #bh ! animal weigh$ #a1egc4e grams1 b two days lat] ! weight _h ris5 to #a1fdd grams4 ,an extract ( #bcg4e grams _h be5 adm9i/]$4 ,"h aga9 ! results appe>$ contradictory4 ,on ,octob] #ba1 #aijg1 a rabbit weigh+ #a1eag grams 0 f$ ) an extract ( #gg4e grams4 ,on ! next day x weigh$ #a1ede grams1 & ! dose 0 repeat$4 ,on ,octob] #bc ! animal weigh$ #a1eca grams1 & ! same am\nt ( extract 0 giv54 ,on ! foll[+ day x weigh$ #a1dhh grams1 & ! dose 0 repeat$4 ,on ,octob] #bf x weigh$ #a1dgd grams1 & aga9 ! dose 0 repeat$4 ,on ,octob] #cj ! weight _h ris5 to #a1ede grams1 & on ,octob] #ca x 0 #a1eei grams4 ,?is animal receiv$ 9 all an extract ( #chg4e grams ( ! dri$ plant4 ,an aque\s extract ( #bjj grams ( ! same 9 "o dose also fail$ to produce ! acute symptoms4 ,^! fe$+ exp]im5ts %[ little ( ! *>act]i/ic action se5 9 ! e>li] exp]im5ts made ) aque\s extracts ei!r ( ! dry plant or ( ! fre% plant pres]v$ ) *lor(orm4 ,9 o!r words1 ! aque\s extract ( ! dri$ plant 0 only slightly poison\s1 yet ! plant f :i* ! extract 0 made conta9$ b>ium4 ,( ?is same dri$ loco #bjj grams 7 !n extract$ ) wat] & dige/$ ) peps9 & f9ally ) pancreat9 9 ! !rmo/at 7#cg4e;,c474 ,! extract 0 conc5trat$ & f$ to a rabbit weigh+ #a1faf grams4 ,aft] five h\rs & t5 m9utes ! animal appe>$ weak 9 ! =e legs & unable to support himself1 & he di$ dur+ ! night4 ,! inte/9es ! foll[+ morn+ 7 f\nd full ( gas1 ! /oma* r$1 ! lungs seem$ normal1 & ! he>t 0 relax$4 ,a rabbit weigh+ #a1ede grams 0 f$ on ,novemb] #ae1 #aijg1 ) a prep>ation made 9 a simil> mann]1 save t ! plant 0 n extract$ ) wat] be=e dige/ion4 ,on ! next day x weigh$ #a1eag grams & on ,novemb] #ai1 #a1cfa grams4 ,! foll[+ day ! weight 0 #a1cah grams2 on ,novemb] #ba1 #a1bcc grams1 & on ! next day #a1afb grams4 ,! animal di$ dur+ ! night1 & ! autopsy 0 made ! foll[+ morn+4 ,! animal 0 greatly emaciat$ & ! subcutane\s fat _h almo/ all disappe>$4 ,! mes5t]ic vessels 7 dilat$1 b ! inte/9es 7 n dilat$4 ,! p]itoneal cavity 0 normal4 ,! kidneys 7 p]haps a little inject$1 & measur$ #c cm4 9 l5g?4 ,! lungs 7 normal4 ,! left v5tricle 0 contract$ & ! re/ ( ! he>t relax$4 ,! liv] 0 normal & ! sple5 app>5tly normal4 ,! /oma* walls 7 d>k1 ow+ to decomposition4 ,no ulc]s 7 se54 ,! supr>5als 7 p]haps a little enl>g$4 ,! exam9ation ( ! bra9 0 negative1 & no clots 7 f\nd4 ,a simil> dige/ion f #bjj grams ( ! same dri$ plant 0 !n a%$ & ! a% treat$ ) acetic acid & fre$ f acid by evaporation on ! ba?4 ,! a% :i* 0 insoluble 9 wat] 0 gr\nd up into a f9e pa/e & ! :ole 0 f$ to a rabbit weigh+ #iib grams4 ,?is animal di$ 9 =ty m9utes1 %[+ ! *>act]i/ic symptoms se5 9 acute cases already describ$4 ,9 ! autopsy ! lungs & o!r organs seem$ p]fectly normal macroscopically4 ,! /oma* walls1 h[ev]1 7 r$d5$ & ec*ymotic1 & ! mes5t]ic vessels 7 dilat$4 ,on ,janu>y #h1 #aijh1 a simil> dige/ion ( ! same bat* 0 treat$ ) a few drops ( sulphuric acid to remove ! b>ium1 & ! filtrate 0 !n treat$ ) lead c>bonate to remove ! sulphuric acid4 ,aft] c>eful filt]+1 ,h#b,s 0 pass$ into ! solution & aft] conc5tration 0 f$ 9 "o dose on ,janu>y #i1 #aijh1 to a rabbit4 ,! foll[+ morn+ ! rabbit _h ga9$ 9 weight4 ,on ,janu>y #ad ?is animal weigh$ #cj grams m ?an its initial weight4 ,! residue ( ?is plant aft] su* a dige/ion1 exam9$ by ! ,hillebr& me?od1 %[$ no weighable am\nt ( b>ium1 s t x c be se5 t b>ium 9 relatively l>ge am\nt 0 f\nd 9 ! plant itself1 b n aft] ! dige/ion4 ,x mu/ !re=e h be5 ! aque\s dige/ion :i* produc$ ! *>act]i/ic symptoms4 ,! exam9ation ( ?is fluid = b>ium might1 h[ev]1 be mislead+1 z ! l>ge am\nt ( proteids w\ld unque/ionably int]f]e ) ! det]m9ation ( ?is am\nt ( b>ium1 unprotect$ by o!r salts & silica1 s t ?is side ( ! inve/igation 0 n pursu$4 ,control fe$+s ) an emulsion ( "o-half gram ea* ( peps9 & pancreat9 prov$ inactive4 ,( ! same ,aragallus lamb]ti #bjj grams 7 simil>ly dige/$ & ! b>ium 0 remov$ ) a few drops ( ,h#b,,s#d1 ! sulphuric acid by ,pb,c,o#c & a little lead acetate1 & ! lead by ,h#b,s4 ,su* an extract x 0 %[n 9 ! previ\s exp]im5t w\ld n kill4 ,h[ev]1 to ?is extract 0 add$ #ajj milligrams ( cry/alliz$ b>ium acetate 9 a solution & a precipitate =m$4 ,nev]!less1 ! liquid & ! precipitate 7 f$ on ,febru>y #a1 #aijh1 to a rabbit weigh+ #a1cjd grams4 ,on ,febru>y #c ! animal weigh$ #a1bcc grams2 on ,febru>y #d1 #a1agf grams2 ,febru>y #e1 #a1abj grams2 ,febru>y #f1 #a1jjf grams2 ,febru>y #g1 #a1bai grams2 ,febru>y #h1 #a1bai grams2 ,febru>y #aj1 #a1cjd grams4 ,z a control = ?is animal1 to make sure t ! loss 9 weight 0 n due to ! acetic acid set free by ! treatm5t ) ,h#b,s1 a simil> aque\s extract ( ! same lot ( ,aragallus lamb]ti 0 precipitat$ ) v mu* m lead acetate ?an 9 ! prec$+ cases & also ) lead subacetate & !n ,h#b,s4 ,aft] evaporat+ to dryness ?is 0 f$ on ,febru>y #h1 #aijh1 to a rabbit weigh+ #a1jce grams4 ,on ,febru>y #aa x weigh$ #a1jba grams2 on ,febru>y #ac1 #a1jia grams1 & on ,febru>y #ae1 #a1abj grams1 %[+ a ga9 9 weight4 ,( ! dri$ ,a/ragalus miss\ri5sis 7,hugo1 ,colo41 ,june1 #aijg7 #djj grams ) an a% cont5t ( #ba4h p] c5t & :i* 0 kn[n to conta9 b>ium 7#c mg4 ,ba,s,o#d 9 ea* #b grams ( ! a%7 7 extract$ ) wat] & f$ 9 f\r doses correspond+ to #ajj grams ea* 9 a p]iod ( f\r days4 ,on ,novemb] #ah1 #aijg1 ! fir/ day ( fe$+1 ?is rabbit weigh$ #a1hef4g grams4 ,fifte5 days lat] x weigh$ #a1ihd4c grams4 ,"o hundr$ grams ( ?is dri$ plant aft] extraction ) wat] 7 f\nd to leave ab\t #ea4a grams#bbf ( ! plant undissolv$4 ,?is :5 a%$ yield$ #h4b grams ( a%4 ,two grams ( ?is a% yield$ #e milligrams ( ,ba,s,o#d4 ,9 o!r words1 ! aque\s extract ( ! plant 0 inactive & ! b>ium 0 f\nd practically unextract$ 9 ! residue ( ! plant4 ,evid5tly ! b>ium 9 ^! dri$ plants _h be5 conv]t$ into an insoluble =m by dry+ or by "s peculi>ity ( its metabolism1 & 0 n extract$ by wat]1 b c\ld be extract$ by dige/+ ! plants ) ! comb9$ dige/ive f]m5ts1 peps9 & pancreat94 ,( ! same dri$ ,a/ragalus miss\ri5sis #bjj grams 7 extract$ ) wat] & ! extract treat$ ) lead c>bonate to remove any possible free sulphates & aft] filt]+ ?is 0 treat$ ) ,h#b,s to remove ! lead4 ,z ! prec$+ exp]im5t %[$ t ! aque\s extract ( ?is dri$ plant 0 h>mless )\t b>ium1 ! writ] decid$ to add b>ium artificially1 & #ajj milligrams ( b>ium phosphate1#bbg cry/alliz$1 0 add$ to ! liquid & ! :ole f$ to a rabbit weigh+ #b1dbc4i grams4 ,! foll[+ morn+ ! rabbit 0 f\nd dead4 ,! autopsy 0 made by ,dr4 ,h4 ,j4 ,wa%burn1 ( ! ,bureau ( ,animal ,indu/ry4 ,he f\nd t ! supr>5als 7 enl>g$ & conge/$1 & !re 7 small areas ( hepatization at ! apex ( ea* lung4 ,!re 7 also acute corrosion areas on ! great] curvature ( ! /oma* & ov] ! upp] portion ( ! duod5um4 ,( ! ,a/ragalus miss\ri5sis us$ 9 ! prec$+ exp]im5ts1 #bjj grams 7 extract$ ?or\ghly ) wat]1 & ! extract correspond+ to #ajj grams1 toge!r ) #hj milligrams ( b>ium phosphate pure1 0 f$ on ,m>* #ab1 #aijh1 to a rabbit weigh+ #a1bfa4e grams4 ,dur+ ?is day ! animal walk$ at times ) an unc]ta9 gait & ! foll[+ morn+ x weigh$ #a1bcc grams4 ,x 0 !n f$ ! re/ ( ! solution1 t is1 ! extract ( ! rema9+ #ajj grams ( ! plant1 b )\t any b>ium4 ,! animal soon develop$ convulsions & di$ 9 a little ov] tw5ty-f\r h\rs aft] ! orig9al fe$+4 ,! autopsy1 :i* 0 made by ,dr4 ,j4 ,r4 ,mohl]1 ( ! ,bureau ( ,animal ,indu/ry1 %[$ t ! muc\s membrane ( ! /oma* 0 m>k$ly hemorrhagic & 9 areas gelat9\s infiltration 0 v m>k$4 ,9 "o portion ( ?is hemorrhagic area !re 0 di/9ct erosion4 ,! l>ge inte/9es 7 full ( gas1 ! lungs 7 normal1 ! he>t 0 relax$1 & ! lungs collaps$4 ,! blood vessels ( ! kidneys 7 m>k$ly engorg$4 ,( ! dri$ ,a/ragalus nitidus 7,woodl& ,p>k1 ,colo41 ,octob]1 #aijg7 :i* 0 report$ by ! ,bureau ( ,*emi/ry z conta9+ no b>ium1 #bjj grams 7 extract$ ) wat] & f$ 9 #ajj-;gram doses = two successive days4 ,! animal increas$ /eadily 9 weight & fifte5 days aft] ! fir/ fe$+ _h ga9$ #ii4b grams4 ,?is am\nt ( ! plant 0 also extract$ ) wat] & ! residue 0 !n dige/$ ) peps9 & pancreat9 9 ! !rmo/at1 z 9 ! previ\s case1 & f$ 9 two doses correspond+ to #ajj grams ea*4 ,?is animal increas$ 9 weight1 ga9+ #fj grams 9 six days & #afe grams 9 addition aft] a fur!r fifte5 days4 ,an ,a/ragalus mollissimus 7,kit ,c>son ,c\nty1 ,colo41 ,decemb]1 #aijf71 :i* 0 also report$ by ! ,bureau ( ,*emi/ry z conta9+ no b>ium1 0 extract$ ) wat]1 & a dose correspond+ to an extract ( #bjj grams ( ! dri$ plant 0 f$ 9 "o dose )\t any s]i\s result4 ,! same am\nt ( ! dri$ plant 0 also simil>ly dige/$ ) peps9 & pancreat9 & f$ 9 two doses1 b )\t ! production ( any symptoms1 ! rabbit ga9+ #fj grams 9 f\r days4 ,( ! ,aragallus lamb]ti 7,hugo1 ,colo41 ,june1 #aijg71 ) an a% cont5t ( #ab4dd p] c5t1 #bej grams 7 a%$ & ! a% treat$ ) acetic acid &1 aft] evaporat+ (f ! acetic acid1 0 extract$ ) wat] & ! a% dige/$ ) peps9 & pancreat94 ,! aque\s extract & ! dige/ion products ( ! a% 7 !n f$ aft] conc5tration1 b )\t any s]i\s effects to ! animal1 indicat+ t 9 ?is plant ! b>ium is 9 a =m insoluble 9 wat] & 9 ! a%+ is fur!r *ang$ s t x c n n[ be made soluble by dige/ion--an opposite result to ! exp]im5t 9 :i* ! b>ium 0 fir/ r5d]$ soluble by dige/ion & ! dige/ion products a%$1 sugge/+ a possibility t plants might be f\nd 9 :i* ! b>ium is n extract$ by dige/ion1 at pres5t a hypo!sis4 ,( dri$ ,a/ragalus decumb5s 7,ephraim1 ,utah1 #aijg71 :i* 0 report$ by ! ,bureau ( ,*emi/ry to conta9 no b>ium1 #bjj grams also fail$ to produce symptoms 9 rabbits by our te/4 ,a solution conta9+ #ej milligrams ( b>ium acetate 7cry/alliz$7 0 mix$ ) an aque\s extract ( #bjj grams ( ! dri$ ,aragallus lamb]ti :i* _h prov$ inactive ph>macologically1 b a precipitate =m$ 7,ba,s,o#d87 & ! extract /ill rema9$ inactive1 sugge/+ t ! "q ( toxicity dep5d$ n only ^u ! pres5ce ( b>ium1 b also :e!r o!r ag5ts1 su* z sulphates1 etc41 might n be pres5t 9 suffici5t am\nt to r5d] ! b>ium insoluble2 t is1 ph>macologically inactive4 ,?is ,aragallus lamb]ti yield$ an a% cont5t ( #cg4c p] c5t1 & ! ,,s#c gr\p 0 e/imat$ at #j4bg p] c5t ( ! a%1 :ile a correspond+ lot :i* 0 obta9$ two ye>s lat] f ! same area yield$ an a% cont5t ( #ab4dd p] c5t & a ,,s#c cont5t ( #j4bd p] c5t ( ! a%4 ,x may be urg$ t ! full le?al dose ( ! b>ium 0 n always f\nd 9 ! plant1 yet x mu/ be rememb]$ t ! toxic action 0 ! resultant ( ! action ( ! total con/itu5ts & t if ! b>ium 0 remov$ ! extract 0 practically h>mless4 ,9 look+ back ov] ! "w ! mo/ suitable prep>ation = produc+ ! *>act]i/ic symptoms 9 rabbits seems to be ! fre%ly gr\nd-up plant mix$ ) wat] & pres]v$ 9 *lor(orm1 = :ile ! dri$ plant might conta9 b>ium1 yet ! aque\s extract 0 (t5 inactive1 sugge/+1 p]haps1 ! pres5ce ( some?+ 9 ! fre% plant :i* aid$ ! solution ( ! b>ium1 ?us acc\nt+ = ! v>iations 9 toxicity ( aque\s extracts made f plants dri$ "u v>y+ conditions4 ,! nature ( ! comp\nd 9 :i* b>ium exi/s 9 ! plant is z yet unkn[n & has n be5 inve/igat$4 ,x is important to rememb] t n only mu/ b>ium be f\nd 9 ! plant to prove poison\s1 b x mu/ be 9 su* a =m t x c be extract$ 9 ! ga/ro-inte/9al canal4 ,! am\nt ( b>ium f\nd 9 v>i\s species ( loco plants w no d\bt v>y1 & p]haps ! ph>macological te/ on rabbits z ! writ] has us$ x may h to be modifi$ = su* plants1 s t at pres5t ! wise/ plan to te/ ^! plants is to det]m9e _! b>ium cont5t & also make ! physiological te/1 z has be5 propos$1 & if ! b>ium cont5t runs l[1 say bel[ #j4aa p] c5t ( ! a%1 9 plants yield+ f #ab to #ah p] c5t ( a%1 !n to increase ! numb] ( fe$+s on ! rabbit4 ,no d\bt on ranges :]e a l>ge numb] ( loco plants are eat51 ) little o!r food1 plants ) a v l[ b>ium cont5t may be poison\s1 b if l>ge am\nts ( o!r food are f$ ! writ] w\ld expect few1 if any1 s]i\s results4 ,z ! writ]'s "w has be5 conf9$ to ! laboratory side ( ! loco-we$ inve/igations no fe$+ exp]im5ts ) b>ium salts h be5 made by him on l>ge animals4 ,su* exp]im5ts %\ld1 ( c\rse1 be made "u range conditions2 t is1 :]e ! wat] & food supply is defici5t4 99 99 99 99 99 ,,footnotes3 #bbf ,"s 0 lo/1 be+ atta*$ to ! clo? us$ 9 squeez+ ! extract4 #bbg ,?is b>ium phosphate 0 det]m9$ by ! ,bureau ( ,*emi/ry to be ,ba,h,p,o#d & to conta9 traces ( iron1 sodium1 & potassium1 b x 0 free f ars5ic4 ,,!oretical ,,antidote ,,= ,,loco-,,we$ ,,poison+4 ,! fact t treatm5t ( ! loco-we$ extract ) a few drops ( sulphuric acid1 :i* w remove ! b>ium1 r5d]s ^! extracts h>mless1 & ev5 app>5tly nutriti\s1 w\ld sugge/ ! !oretical antidotal treatm5t to be ) sulphates1 9 ! =m1 p]haps1 ( epsom salts1 b p]haps alkal9e bic>bonates may be pres5t 9 ! /oma*1 ei!r due to less5$ acidity ( ! /oma* or f dr9k+ alkal9e wat]s1 9 :i* case ! precipitation ( ! b>ium by sulphates w\ld presumably be int]f]$ )1 & ?us ! treatm5t be r5d]$ ineffectual4#bbh ,x is int]e/+ to note t mo/ ( ! rem$ies propos$ = ! successful treatm5t ( loco$ animals conta9 sulphates4#bbi ,9 ,/or]'s exp]im5ts on fe$+ rats ) b>ium c>bonate x 0 f\nd t ! b>ium c>bonate w\ld kill !m1 b if calcium c>bonate 0 mix$ ) ! b>ium ! rats surviv$1 sugge/+ an antidotal action4 ,?is app>5t antagonism des]ves fur!r /udy & may lead to practical results4#bcj ,a some:at simil> antagonism = at lea/ a "p ( ! action ( b>ium has be5 claim$ to exi/ betwe5 b>ium & potassium4#bca ,h[ev]1 extracts ( a%$ plants1 treat$ ) acetic acid1 :i* conta9$ calcium & potassium1 caus$ dea? 9 ! exp]im5ts ( ! writ]1 b no "w has yet be5 done by him z to ! antidotal action ( calcium c>bonate on b>ium4 ,!n1 too1 z ,ldek+#bcb po9t$ out1 l>ge quantities ( calcium *lorid may int]f]e ) ! precipitation ( b>ium z a sulphate4 ,x is well kn[n t ! pres5ce ( v>i\s salts influ5ces ! solubility ( b>ium sulphate 9 wat]1#bcc & ! fact t b>ium has be5 f\nd 9 solution 9 ! ur9e 9 ! pres5ce ( sulphates %[s t ! precipitation ( b>ium z a sulphate 9 ! body is n s simple z 9 te/-tube exp]im5ts4#bcd ,aga91 9 v dilute solutions1 su* z mu/ necess>ily occur at any "o "t 9 ! /oma*1 ! precipitate ) sulphates only sl[ly =ms & ! b>ium may be absorb$ be=e ! insoluble comp\nd c be =m$4#bce ,evid5tly an important po9t to be consid]$ 9 ! antidotal treatm5t ( loco$ animals ) sulphates is ! possibility ( induc+ a ga/ritis1 ) its att5dant loss ( weight4 ,x !re=e seems app>5t t ! prop] treatm5t at pres5t is prev5tive--t is1 removal f ! plants4 ,lew9#bcf has sugge/$ ! possibility ( acquir+ "s immunity to b>ium1 b our exp]im5ts po9t aga9/ ! production ( any practical immunity4 99 99 99 99 99 ,,footnotes3 #bbh ,m5del1 ,l4 ,b41 & ,si*]1 ,d4 ,f41 l4 c41 p4 #adh4 #bbi ,mayo1 ,n4 ,s4 ,"s ,obs]vations ^u ,loco4 ,kans4 ,/ate ,agric4 ,coll4 ,bul4 #ce1 p4 #aai4 #ahic4 #bcj ,/or]1 ,f4 ,h4 ,exp]im5ts on ,fe$+ ,mice ) ,pa9t]'s ,putty & ) ,o!r ,mixtures ( ,pigm5ts & ,oils4 ,bul4 ( ,bussey ,in/itute1 vol4 #b1 p4 #bgd4 #ahhd4 #bca ,brunton1 ,t4 ,l41 & ,ca%1 ,j4 ,t4 ,contribution to ,our ,k ( ! ,connection betwe5 ,*emical ,con/itution1 ,physiological ,action1 & ,antagonism4 ,philos4 ,trans4 ,royal ,soc4 ,london1 ,i1 vol4 #age1 p4 #bbi4 #ahhd4 #bcb ,ldek+1 ,c4 ,analyse d4 ,b>ytgruppe4 ,zeits4 f4 ,anal4 ,*em41 vol4 #bi1 p4 #eef4 #ahij4 #bcc ,fraps1 ,g4 ,s4 ,solubility ( ,b>ium ,sulphate 9 ,f]ric ,*loride1 ,alum9um ,*loride1 & ,magnesium ,*loride4 ,am]4 ,*em4 ,j\rn41 vol4 #bg1 p4 #bhh4 #aijb4 #bcd ,santi has paid special att5tion to ! solubility ( b>ium 9 ! body4 #bce ,fres5ius1 ,c4 ,g4 ,man4 ( ,qualitat4 ,*em4 ,anal4 ,tr4 by ,h4 ,l4 ,wells1 #aijd1 p4 #adh4 #bcf ,lew91 ,l4 ,neb5wirkung5 d4 ,arzneimittel1 #b ed41 p4 #dci4 #ahic4 ,,action ,,( ,,b>ium ,,on ,,dome/ic ,,& ,,f>m ,,animals4 ,b>ium 9 ! =m ( b>ium *lorid has be5 rec5tly introduc$ into vet]9>y !rapeutics by ,dieck]h(f#bcg 9 ! treatm5t ( con/ipation1 b ,w9sl[#bch says t ! doses requir$ to produce ca?>sis 9 ! horse are almo/ toxic1 & he advises aga9/ ! intrav5\s use ( ?is rem$y4 ,frhn]#bci has c>efully summ>iz$ ! lit]ature on ! use ( b>ium *lorid 9 vet]9>y "w1 & reports t its use 9 ! ,zri* cl9ic has rec5tly be5 s unsatisfactory t x is n[ seldom employ$ & t 9 ! la/ t5 ye>s ! prepond]ance ( reports 9 ! lit]ature are unfavorable to ! use ( ?is ag5t 9 colic4 ,aft] ! adm9i/ration p] os1 mu* ( ! b>ium mu/ be c>ri$ (f 9 ! di>rheal /ools4 ,a numb] ( dea?s 9 horses h be5 attribut$ to ! use ( ?is ag5t4 ,no d\bt ! pres5ce ( sulphates1 etc41 d]iv$ f ! food w\ld r5d] ! b>ium insoluble 9 ! ga/ro-inte/9al tract1 & ?is w\ld expla9 ! lack ( poison\s action 9 c]ta9 ( ! cases 9 :i* l>ge doses ( b>ium prov$ h>mless4 ,hus>d & ,biron adm9i/]$ daily doses ( #h grams ( b>ium *lorid to "o horse1 & ! same am\nt ( b>ium c>bonate to a second horse1 = sev]al days4 ,a =tnight lat] ! fir/ horse unexpect$ly di$1 & ! second a few days lat]4 ,! po/-mortem exam9ation 0 negative4#bdj ,a ?ird horse f$ ) b>ium c>bonate also di$ sudd5ly4 ,rec5tly b>ium occurr+ 9 br9e has giv5 rise to acute poison+ 9 /ock4#bda ,9 a case report$ by ,/iet5ro?#bdb ! horse di$ aft] ! injection ( #j4e gram ( b>ium *lorid into ! jugul> ve94 ,a numb] ( sudd5 dea?s 9 horses aft] ! intrav5\s injection ( #j4g gram & ov] ( b>ium *lorid h be5 collect$ by ,frhn]4#bdc ,! le?al dose by m\? = acute poison+ ) b>ium *lorid 9 horses lies betwe5 #h to #ab grams1 :ile cattle require mu* l>g] doses 7#dj grams7#bdd to induce dea?4 ,dieck]h(f advises aga9/ ! use ( b>ium *lorid 9 ! treatm5t ( con/ipation 9 %eep4 ,aft] a dose ( #f grams ( b>ium *lorid a #b-ye>-old heal?y ram appe>$ p]fectly well1 b ! foll[+ day he 0 depress$1 refus$ to eat1 /agg]$1 & became s weak t he 0 unable to /&4 ,! muscles ( ! extremities 7 p>alyz$ & ! animal di$4 ,! po/-mortem exam9ation reveal$ o$ema ( ! lungs1 slight cl\d9ess ( ! he>t muscles1 num]\s small hemorrhagic spots on ! muc\s membrane ( ! small inte/9e1 & /agnation ( ! blood 9 ! vessels ( ! small & l>ge inte/9es4 ,simil> symptoms & lesions 7 f\nd 9 a lamb #d mon?s old :i* 0 giv5 p] os #f4j grams ( b>ium *lorid dissolv$ 9 #bjj grams ( di/ill$ wat]4#bde ,poison+s ) b>ium c>bonate h also be5 report$ 9 pigs4#bdf ,dome/ic animals pa/ur$ 9 ! neighborhood ( b>ite deposits soon succumb1#bdg & accid5tal cases ( poison+ are report$ 9 c[s4 ,poison+ 9 dogs has also be5 report$ aft] ! subcutane\s use ( ?is ag5t4#bdh ,l9ossi] says t if ! b>ium salts are us$ = any "t ! salts are deposit$ 9 v>i\s organs1 l>gely 9 ! kidneys1 bra91 & m$ulla1 b especially 9 ! bones4#bdi 99 99 99 99 99 ,,footnotes3 #bcg ,dieck]h(f4 ,ueb] d4 ,wirkung d4 ,*lorb>yum bei ,pf]d51 ,r9d]n und ,s*af54 ,b]l9] ,?i]rztl4 ,wo*41 p4 #bfe2 see also pp4 #cac & #ccg1 #ahie2 ,ab/ract ,9 ,vet4 ,mag41 vol4 #b1 p4 #cfj4 #ahie4 #bch ,w9sl[1 ,k4 ,vet4 ,mat]ia ,m$ica & ,!rapeutics1 p4 #aeb4 #aija4 #bci ,frhn]1 ,e4 ,lehrb4 d4 ,arzneimittellehre1 p4 #cii4 #aijf4 ,frhn] gives a detail$ acc\nt ( ^! cases4 ,orig9al note 9 ,ehrh>dt1 ,j4 ,erfahrung5 4 lt]e u4 neue ,arzneimittel4 ,s*weiz] ,ar*iv4 f4 ,?i]heilk41 vol4 #da1 p4 #dd4 #ahii4 #bdj ,pelleti]4 ,obs]vations on ,/rontian4 ,j\rn4 ,nat4 ,philos41 vol4 #a1 p4 #ebi4 #agig2 orig9al 9 ,annales de ,*imie1 vol4 #ba1 p4 #abg4 #agig4 #bda ,h[>d1 ,c4 ,d4 ,occurr5ce ( ,b>ium 9 ! ,ohio ,valley ,br9es & ,its ,relation to ,/ock ,poison+4 ,w4 ,va4 ,univ4 ,agric4 ,exp]4 ,/a4 ,bul4 #ajc4 #aijf4 #bdb ,/iet5ro?4 ,ueb] ,*lorb>ium bei d] ,kolik d] ,pf]de4 ,b]l9] ,?i]rztl4 ,wo*41 p4 #af4 #ahii4 #bdc ,frhn]1 ,e4 ,lehrb4 d4 ,toxikol41 #b ed41 p4 #aaf4 #aija4 #bdd ,frhn]1 ,e41 l4 c41 p4 #aaf4 ,see simil> reports 9 ,vet]9>ian1 vol4 #fh1 p4 #egb1 #ahie1 & vol4 #fi1 p4 #bbh1 #ahif2 ,zeits4 f4 ,vet]9rk41 vol4 #h1 pp4 #ii & #baa1 #ahif2 ,nagl]1 ,f41 ,b]l9] ,?i]rztl4 ,wo*41 p4 #fe4 #ahif4 #bde ,dieck]h(f1 ,w4 ,vet4 ,mag41 vol4 #b1 p4 #cfb4 #ahie4 #bdf ,kabitz1 ,h4 ,ueb] d4 ,wirkung e9ig] ,b>yumsalze beim ,s*we94 ,deuts*4 ,?i]rztl4 ,wo*41 vol4 #ac1 p4 #cag4 #aije4 #bdg ,p>kes4 ,*em4 ,essays1 vol4 #b1 p4 #bac4 ,quot$ by ,*ri/ison1 ,r41 9 ,treatise on ,poisons1 ,ed9burgh1 #d ed41 p4 #eha1 #ahde4--;,fu*s1 ,c4 ,j4 ,v]giftungsflle dur* salzsur5 ,b>yt beim ,r9dvieh4 ,?i]rztl4 ,mit!il41 vol4 #e1 pp4 #acc1 #aed4 #ahgj4 #bdh ,falk4 ,zur ,v]gift4 von ,hund5 mit ,*lorb>ium4 ,b]l9] ,?i]rztl4 ,wo*41 p4 #dj4 #ahig4--,s*irm]1 ,*lorb>iumv]gift4 beim ,hunde4 ,b]l9] ,?i]rztl4 ,wo*41 vol4 #bc1 p4 #bfh4 #ahig4 #bdi ,l9ossi]1 ,g4 ,de la ,localisation du ,b>yum dans l',organisme la ,suite de l',intoxication ,*ronique p> un ,sel de ,b>yum4 ,comp4 ,r5d4 ,hebd4 ,soc4 de ,biol41 #h s41 vol4 #d1 p4 #abc4 #ahhg4 ,,note4--,o!r cases ( poison+ 9 animals may be f\nd 9 ,m>d]1 ,beitrag z4 ,giftwirkung des ,b>yum *loratum4 ,b]l9] ,?i]rtzl4 ,wo*41 vol4 #cg1 p4 #dcf4 #ahig2 ,absi*tli*e ,v]gift4 mit ,*lorb>ium4 ,zeits4 f4 ,vet]9rk41 vol4 #i4 p4 #gb4 #ahig4 ,,application ,,( ,,! ,,results ,,( ,,^! ,,inve/igations ,,to ,,! ,,range4 ,x has be5 calculat$ t a m$ium e/imate ( food = cattle on gre5 fodd] is ab\t #fj p\nds 7#cj kilos7 a day4#bej ,calculat+ ?is entirely 9 t]ms ( ,aragallus lamb]ti & all[+ #aj p] c5t ( moi/ure = ^! plants 7,sayre7 w\ld make #bg kilos ( dry loco eat5 by ea* animal p] diem4 ,9 ! analysis ( ! writ] ( "o ,aragallus lamb]ti f ,hugo1 ,colo41 x 0 f\nd to yield #ab4dd p] c5t ( a%1 & ! b>ium cont5t correspond$ to #b4f milligrams ,ba,s,o#d 9 ea* gram ( ! a%4 ,?is w\ld correspond to #aj4bd grams ( b>ium acetate 7,ba7,c#b;,h#c,o#b7b ,h#b,o7 or #i4ae grams ( b>ium *lorid 7,ba,cl#b #b;,h#b,o7 p] diem4 ,?is am\nt daily adm9i/]$ w\ld1 !oretically1 readily produce *ronic poison+ ow+ to ! accumulation 9 ! sy/em1 z 0 %[n 9 ! case ( rabbits4 ,!re is1 h[ev]1 "s "q z to :e!r ?is full !oretical am\nt ( loco plants is eat5 on ! range1 & ! e/imate has be5 made t "o-six? ( ?is am\nt only w\ld be actually tak54 ,x mu/ be rememb]$1 z ,/alk] po9t$ out1 t loco$ animals develop an especial ta/e = ^! plants & aft] a "t reject o!r food1 s t :ile ! numb] ( loco plants at fir/ tak5 may be small1 yet lat]1 p]haps1 x is great]4 ,a "p ( ?is b>ium1 h[ev]1 may n be tak5 up by ! sy/em1 b may pass out undissolv$4 ,no actual exp]im5ts h yet be5 made ) cattle by fe$+ small doses ( ! pure salt4 ,no d\bt m ( ! pure b>ium salts w be requir$ to produce symptoms ( poison+ 9 animals ?an w\ld be necess>y 9 ! case ( ! =m ( b>ium f\nd 9 ! plant1 z 9 ! loco-we$ ! b>ium is probably bett] protect$ f precipitation ?an are ! b>ium salts :5 dissolv$ 9 wat] alone4 99 99 99 99 99 ,,footnotes3 #bej ,lane1 ,c4 ,b4 ,soil+ ,crop ,exp]im5ts4 ,n4 ,j4 ,agric4 ,exp]4 ,/a4 ,bul4 #aeh1 p4 #ah4 #aijb4--,woll1 ,f4 ,w4 ,"o ,hundr$ ,am]ican ,rations = ,dairy ,c[s4 ,univ4 ,wis4 ,agric4 ,exp]4 ,/a4 ,bul4 #ch1 p4 #ab4 #ahid4--,n4 ,j4 ,/ate ,agric4 ,exp]4 ,/a41 #bj? ,ann4 ,rept4 7#ahii71 p4 #aic4 #aijj4 ,,conclusions4#bea 7#a7 ,conditions analog\s to ^? met ) 9 loco$ animals occur 9 o!r portions ( ! _w1 especially ,au/ralia4 7#b7 ,! ma9 symptoms describ$ 9 /ock on ! range c be reproduc$ on rabbits by fe$+ extracts ( c]ta9 loco plants4 ,^? especially ref]r$ to "h "u ! t]m loco plants are ,a/ragalus mollissimus & ,aragallus lamb]ti4 7#c7 ,! production ( *ronic symptoms 9 rabbits is a crucial te/ ( ! ph>macological activity ( ^! plants4 7#d7 ,! inorganic con/itu5ts1 especially b>ium1 are responsible = ?is action1 at lea/ 9 ! plants collect$ at ,hugo1 ,colo4 ,p]haps 9 o!r portions ( ! c\ntry o!r poison\s pr9ciples may be f\nd4 7#e7 ,a close analogy exi/s betwe5 ! cl9ical symptoms & pa?ological f9d+s 9 b>ium poison+ & ^? result+ f fe$+ extracts ( c]ta9 loco plants4 ,small doses ( b>ium salts may be adm9i/]$ to rabbits )\t app>5t effect1 b sudd5ly acute symptoms set 9 analog\s to :at is report$ on ! range4 7#f7 ,! adm9i/ration ( sulphates1 especially epsom salts1 to =m insoluble b>ium sulphate w\ld be ! *emical antidote :i* w\ld logically be inf]r$ f ! laboratory "w1 b ( necessity ?is w\ld h to be frequ5tly adm9i/]$ & its value aft] hi/ological *anges 9 ! organs h occurr$ rema9s to be settl$4 ,b ev5 ! treatm5t ( acute cases ( b>ium poison+ 9 man is n always successful1 ev5 :5 sulphates comb9$ ) symptomatic treatm5t are employ$4 ,! conditions "u :i* ! sulphates fail to precipitate b>ium mu/ be consid]$4 ,at pres5t x seems be/ to rely on prev5tive measures r ?an on antidotal treatm5t4 7#g7 ,loco plants gr[n on c]ta9 soils are inactive ph>macologically & conta9 no b>ium4 ,9 dry+ c]ta9 loco plants ! b>ium app>5tly is r5d]$ insoluble s t x is n extract$ by wat]1 b c usually be extract$ by dige/ion ) ! dige/ive f]m5ts4 7#h7 ,! b>ium to be h>mful mu/ be 9 su* a =m z to be dissolv$ out by dige/ion4 7#i7 ,9 decid+ :e!r plants are poison\s x is desirable n m]ely to te/ ! aque\s or alcoholic extract1 b also ! extracts obta9$ by dige/+ ^! plants ) ! f]m5ts :i* occur 9 ! ga/ro-inte/9al tract4 7#aj7 ,x is important t ! a% ( plants1 especially ^? gr[n on uncultivat$ soil1 z on our unirrigat$ pla9s1 be exam9$ = v>i\s metals1 us+ me?ods simil> to ^? by :i* rocks are n[ analyz$ 9 ! laboratory ( ! ,unit$ ,/ates ,geological ,survey4 7#aa7 ,x is desirable to /udy v>i\s obscure *ronic conditions1 su* z la?yrism1 ) a view to det]m9e ! inorganic con/itu5ts ( la?yrus & o!r families ( plants4 99 99 99 99 99 ,,footnotes3 #bea ,rsum ( ! results ( ! loco-we$ inve/igations c>ri$ on by ! ,bureau ( ,plant ,indu/ry 0 issu$ z ,bullet9 #aba1 "p #c1 ,bureau ( ,plant ,indu/ry1 on ,janu>y #bh1 #aijh1 9 ! =m ( pap]s by ,c4 ,dwight ,m>% & ,alb]t ,c4 ,craw=d1 respectively1 "u ! titles ,results ( ,loco-,we$ ,inve/igations 9 ! ,field & ,laboratory ,"w on ,loco-,we$ ,inve/igations4 ,,index4 ,page4 ,abortion1 c[s1 caus$ by loco poison+1 #ac rabbits1 caus$ by loco & b>ium poison+1 #da1 #db1 #fb ,acid1 acetic1 f\nd 9 loco-we$1 #bf ,acqua1 ,c41 ref]5ce to "w1 #eb ,africa1 ,s\?1 goat disease1 #ag ,alfalfa1 extract1 exp]im5ts1 #bh ,alkali deposits1 suppos$ to cause loco disease1 #aa ,alkaloidal reactions1 loco plants1 #bj1 #bc1 #bg1 #bh ,am>an?us graecizans1 suppos$ cause ( loco disease1 #aj ,am]ican ,ph>maceutical ,association1 proce$+s1 ref]5ce1 #aj ,ammonia obta9$ f loco plants1 #bf ,ammonium sulphid precipitate1 effect on rabbits1 #ej ,anmia1 progress+1 fundam5tal *>act]i/ic ( loco disease1 #af1 #ai ,analyses ( loco plants1 #ba1 #bb1 #bc1 #cb ,&]son1 ,f4 ,w41 ref]5ces to "w1 #aj1 #ab1 #ad1 #ah1 #ai ,animals1 c>nivor\s & h]bivor\s1 v>y+ immunity to loco disease1 #bc dome/ic1 b>ium poison+1 effects1 #gb exp]im5ts ) b>ium salts 9 laboratory1 #eg-fb f>m1 b>ium poison+1 effects1 #gb loco$1 autopsies1 #ah-ai1 #bd1 #bf1 #cj1 #cd1 #cf-dc1 #de cl9ical symptoms1 #ab-af pa?ological conditions z describ$ on ! range1 #ah-ai poison$ by b>ium1 autopsies1 #eg-fa1 #fd1 #fg1 #gc1 #gd "y1 susceptibility to loco poison+1 #ae ,antelopes1 susceptibility to loco disease1 #ab ,antidote to loco poison1 !oretical1 #ga-gb ,aragallus lamb]ti1 a% det]m9ation1 #ed b>ium det]m9ation1 #ed1 #ef extracts1 uses 9 laboratory exp]im5ts1 fe$+ animals1 #bj1 #bc-be1 #cg1 #db1 #dd-di1 #ff-fh1 #gj prop]ties1 inve/igations1 #bj-ba1 #bc-be1 #cb spicatus1 /udy & exp]im5ts1 #cc spp41 cause ( loco disease1 #aj1 #bj-cd uses1 m$ic9al & toxic prop]ties1 #ce ,ars5ic poison+1 ref]5ces1 #di ,a% det]m9ations ( loco plants1 #ed-ee extract f loco plants1 exp]im5ts1 #dh-eb loco plants1 b>ium det]m9ations1 #ee-eg importance ( analysis1 #gf ,a/ragalus bigel[ii1 extract1 fatal to rabbit1 #ch bisulcatus1 extract fatal to rabbit1 #ch decumb5s1 extracts1 fe$+ exp]im5ts ) rabbits1 #gj ,a/ragalus exscapus1 b>ium report$ by ,c4 ,spr5gel1 #ec hornii1 poison\s prop]ties1 /udy1 #ai l5tig9osus1 poison\s prop]ties1 /udy1 #ai m5ziesii1 /ock poison+1 #bj miss\ri5sis1 a% cont5t & b>ium det]m9ation1 #ef extracts1 fe$+ exp]im5ts ) rabbits1 #fh-fi mollissimus1 di/illate1 composition1 #bf extracts1 exp]im5ts 9 fe$+ animals1 #bb1 #bc-be1 #bg-cc1 #cf-di1 #gj inve/igations1 exp]im5ts1 & analyses1 #ba-cd physiological action1 #bb1 #bd-be mortoni1 a deadly %eep poison1 #bj nitidus extracts1 fe$+ exp]im5ts ) rabbits1 #ch1 #fi spp41 cause ( loco disease1 #aj1 #ai-cd total a% det]m9ations1 #ed-ee uses1 m$ic9al & toxic prop]ties1 #ce v>ieties conta9+ no b>ium1 #eg ,au/ralia1 disease simil> to loco poison1 description1 #af-ah ,autopsies on animals aft] b>ium poison+1 #eg-fa1 #fg1 #gc1 #gd loco poison+1 #ah-ai1 #bd1 #bf1 #cj1 #cd1 #cf-dc1 #de ,ba*em1 ,c41 ref]5ce to "w1 #ej ,bailey1 ,f4 ,m41 ref]5ce to "w1 #ag ,b>ium acetate1 fe$+ exp]im5ts on animals 9 laboratory1 #eg-fb action on f>m & dome/ic animals1 #gb-gd c>bonate1 fe$+ exp]im5ts on animals 9 laboratory1 #fa1 #fb rats1 #ga hypod]mic injection1 cats1 fatal results1 #fb *lorid1 effects on human be+s1 #fc-fe fe$+ exp]im5ts ) animals 9 laboratory1 #fj-fb use 9 vet]9>y !rapeutics1 dang]s1 #gb-gc cont5t ( rocks 9 ,rocky ,m\nta9s1 #ed det]m9ation 9 a% ( loco plants1 #ed1 #ee-eg discov]y 9 loco plants1 fe$+ exp]im5ts1 #e fe$+ exp]im5ts ) range cattle1 desirability1 #ga h>mful :5 9 soluble =m1 #gf 9 br9e1 poison+ /ock1 #gc well wat] 9 ,engl&1 #eg insoluble aft] dry+ loco plants1 extraction ) dige/ive f]m5ts1 #gf nitrate1 fe$+ exp]im5ts on animals 9 laboratory1 results1 #fa1 #fb phosphate1 analysis by ,bureau ( ,*emi/ry1 #fi poison+1 exp]im5tal1 pa?ological lesions1 #fe horses1 %eep1 & pigs1 #gc1 #gd man1 symptoms1 results1 #fb-fe pres5ce 9 c]ta9 vegetable sub/ances1 #ec salts1 fe$+ exp]im5ts on animals 9 laboratory1 #eg-fb toxicity ( diff]5t solutions1 #fd relation ( altitude1 climate1 & v>y+ comb9ations1 #fe use 9 m$ic9e1 #fb-fe1 #gb-gc sulphate1 nontoxic on acc\nt ( insolubility1 #ec ,b>r[s1 ,d4 ,p41 ref]5ce to "w1 #ce ,b>y1 ,a41 ref]5ces to "w1 #ec1 #ei1 #fj ,baum1 ref]5ce to "w1 #fd ,bee*1 b>ium pres5t1 #ec ,be]1 ,mexico1 use ( crazy we$1 #bj ,bellis>i1 ,g41 ref]5ce to "w1 #fd ,b]yllium *lorid1 effect on rabbits1 #ej ,b9et1 ,p41 ref]5ce to "w1 #ei ,bir*1 b>ium pres5t1 #ec ,birdsall1 ,w4 ,r41 exp]im5ts ) ,aragallus lamb]ti1 #bj ,blank9%ip1 ,j4 ,w41 ref]5ces to "w1 #aa1 #cd ,blood1 clots on bra91 #ah1 #bf1 #cg1 #db1 #fe ,boehm1 ,r41 ref]5ce to "w1 #eh ,bhm1 ,c4 ,r41 ref]5ce to "w1 #ej ,bray1 ,w4 ,c41 ref]5ce to "w1 #ec ,brew]1 ,w4 ,h41 ref]5ce to "w1 #bj ,br9e1 b>ium cont5t1 produc+ acute poison+ 9 /ock1 #gc ,brodie1 ,b4 ,c41 ref]5ce to "w1 #fa ,brunton1 ,t4 ,l41 ref]5ce to "w1 #gb ,burgassi1 ,g41 ref]5ce to "w1 #eb ,csium *lorid1 exp]im5ts on rabbits1 #ea occurr5ce 9 plants1 toxicity1 #ea ,calcium acetate1 exp]im5ts on rabbits1 #eb c>bonate1 antidotal to b>ium1 #ga exp]im5ts on rabbits1 #eb occurr5ce 9 loco plants1 #be1 #bg ,cambi]1 ,j41 exp]im5ts ) loco plants1 #bf-bh ,canada1 disease caus$ by eat+ ragwort1 #ag fre$om f loco disease1 #i ,cannabis sativa1 suppos$ cause ( loco$ conditions 9 ,mexico1 #aj ,caprioides aureum1 suppos$ cause ( loco disease1 #aj ,c>p5t]1 ,j4 ,s41 ref]5ces to "w1 #fc1 #fd ,ca%1 ,j4 ,t41 ref]5ce to "w1 #gb ,cats1 b>ium injection exp]im5ts1 #fb loco-plant exp]im5ts1 #bb1 #bd1 #cj ,see also ,kitt5s4 ,cattle1 b>ium fe$+ exp]im5ts "u range conditions1 desirability1 #ga daily ration ( gre5 fodd]1 toxic effects ( loco plants1 #gd loco poison+1 notes1 #ab1 #ai1 #bj1 #bb1 #bh loco$1 fle% h>mless1 #fe poison$ ) b>ium *lorid1 fle% h>mless1 #fe range1 b>ium fe$+ exp]im5ts1 desirability1 #ga susceptibility to loco disease1 #ab ,c]ium *lorid1 exp]im5ts on rabbits1 #ej ,*emical exp]im5ts ) loco plants1 #df-eg ,*emicals 9 aque\s solution1 effects on rabbits1 #ej-eb ,*emi/ry1 ,bureau1 a% & b>ium det]m9ations1 loco plants1 #ed1 #ef ,*esnut1 ,v4 ,k41 ref]5ces to "w1 #aj1 #aa1 #cc ,*evalli]1 ,a41 ref]5ce to "w1 #fd ,*ri/ison1 ,r41 ref]5ces to "w1 #fb1 #fc ,c(fee sub/itute1 use ( se$s ( ,a/ragalus boeticus1 #ce ,colli]1 ,pet]1 /udy ( loco plants1 #ba ,colorado1 loco disease exp]im5ts1 results1 #e loss ( /ock f loco disease1 #ahih1 #i ,con/ipation1 treatm5t ( animals ) b>ium1 dang]1 #gc ,cotyl$on v5tricosa1 cause ( n5ta1 a goat disease1 #ag ,c\rt91 ref]5ce to "w1 #fd ,c[s1 abortion caus$ by loco poison+1 #ac autopsies aft] loco poison+1 #ah loco$1 symptoms1 #be susceptibility to loco disease1 #ab ,craw=d1 ,alb]t ,c41 loco inve/igations1 ref]5ce to publi%$ pap]1 #ge ,crazy we$4 ,see ,loco plants4 ,crotal>ia sagittalis1 cause ( loco disease1 *emical /udy1 #aj1 #bf-bg exp]im5ts ) horses1 #bf-bg ,curtice1 ,c41 ref]5ce to "w1 #ca ,cyon1 ,m41 ref]5ce to "w1 #ei ,cyprus1 loco disease ( cattle1 %eep1 & goats1 #bb ,d>l+ pea1 effects on horses & %eep 9 ,au/ralia1 #af fe$+ %eep1 effects simil> to loco poison+1 #af-ag ,day1 ,m4 ,g41 exp]im5ts ) ,a/ragalus mollissimus & ,aragallus lamb]ti1 #ae1 #bc-bf ,delph9ium spp41 suppos$ cause ( loco disease1 #aj ,dem\ssy1 ,e41 ref]5ce to "w1 #ec ,didymium *lorid1 exp]im5ts on rabbits1 #ea ,dieck]h(f1 ,w41 ref]5ces to "w1 #gb1 #gd ,dige/ion ( loco plants1 exp]im5ts1 #ff1 #fg1 #fh1 #gj ,diuretic1 use ( ,a/ragalus glycophyllus1 #ce ,dogs1 b>ium fe$+ exp]im5ts1 results1 #fb poison+1 subcutane\s injection1 #gd loco-plant fe$+ exp]im5ts1 #bb1 #bc1 #cj1 #ec ,donkeys1 susceptibility to loco disease1 #ab ,dworzak1 ,h41 ref]5ce to "w1 #ec ,dyr5=?1 ref]5ce to "w1 #ed ,ea/wood1 ,a41 ref]5ces to "w1 #aj1 #ab ,eck>d1 ,g4 ,e41 ref]5ce to "w1 #ec ,ehrh>dt1 ,j41 ref]5ce to "w1 #gc ,emory1 ,w4 ,h41 ref]5ce to "w1 #ai ,es*ri*t1 ref]5ce to "w1 #fd ,exp]im5ts1 laboratory1 ) b>ium salts1 #eg-fb loco plants1 #cf-ef1 #ff-ga loco poison+ & b>ium fe$+1 results1 #e ,extracts ( loco plants1 dige/ion ) peps9 & pancreat91 exp]im5ts1 #ff-fh te/+1 importance1 #gf use 9 laboratory exp]im5ts1 v>y+ toxicity1 #cf-di1 #ff-ga ,falk1 ref]5ce to "w1 #gd ,fau/1 ,e4 ,s41 ref]5ce to "w1 #ca ,faville1 ref]5ce to "w1 #ah ,fellet>1 ,e41 ref]5ce to "w1 #fb ,f]guson1 ,j4 ,c41 ref]5ce to "w1 #fc ,filippi1 ,e41 ref]5ce to "w1 #fb ,flet*]1 ,j41 ref]5ce to "w1 #aj ,fleurot1 ref]5ce to "w1 #ce ,fol91 ,o41 ref]5ce to "w1 #ef ,food1 use ( loco plants1 #ce1 #gd ,=age1 use ( ,a/ragalus nuttallianus & ,a4 crassic>pus1 #ce ,=*hamm]1 ,j4 ,g41 ref]5ce to "w1 #ec ,fo/]1 ,f4 ,b41 ref]5ce to "w1 #bf ,frank=t]1 ,g4 ,b41 ref]5ce to "w1 #ce ,fraps1 ,g4 ,s41 ref]5ce to "w1 #gb ,fres5ius1 ,c4 ,g41 ref]5ce to "w1 #gb ,fritill>ia pudica1 suppos$ cause ( loco disease1 #aj ,frogs1 loco-plant exp]im5ts1 #ag1 #bb1 #bd poison+1 #ag1 #bd ,frhli*1 ,a41 ref]5ce to "w1 #fe ,frhn]1 ,e41 ref]5ce to "w1 #gc ,fu*s1 ,c4 ,j41 ref]5ces to "w1 #fe1 #gd ,fun>o1 ,a41 ref]5ce to "w1 #fd ,g>banzillo1 ,spani% "n = ,a/ragalus mollissimus1 d]ivation1 #aa ,gibbons1 ,h41 ref]5ce to "w1 #ba ,giv5s1 ,a4 ,j41 ref]5ces to "w1 #aj1 #ce ,gl&s1 swell+1 9 loco$ animals1 note1 #fc result ( use ( b>ium on human be+s1 #fc ,glov]1 ,r4 ,m41 ref]5ce to "w1 #fa ,goat disease1 ,s\? ,africa1 note1 #ag ,goats1 loco poison+1 #bb susceptibility to loco disease1 #ab ,gordon1 ,p4 ,r41 ref]5ce to "w1 #ag ,grass /agg]s1 ,texas loco disease1 symptoms1 description1 #aa ,gre%(f1 ,m41 ref]5ce to "w1 #ce ,gu9ea pig1 autopsy aft] loco poison+1 #dc pigs1 loco-plant fe$+ exp]im5ts1 #cb1 #dc ,gu?rie1 ,f4 ,b41 ref]5ce to "w1 #ag ,hairs on plants cause ( loco disease1 sugge/ion1 #bb1 #bh ,halluc9ations caus$ by loco poison1 #ac ,h>e1 ,h4 ,a41 ref]5ce to "w1 #fc ,h>k9s1 ,w4 ,d41 ref]5ce to "w1 #di ,hayes1 ,m4 ,h41 description ( ,texas grass /agg]s1 #aa ,hefftn]1 ,a41 ref]5ce to "w1 #eh ,heilborn1 ,f41 ref]5ce to "w1 #ei ,hill1 ,j4 ,r41 ref]5ce to "w1 #bb ,hillebr&1 me?od ( det]m9ation ( b>ium 9 a% ( loco plants1 #ef /atem5t z to b>ium cont5t ( rocks 9 ,rocky ,m\nta9s1 #ed ,h(fmann1 ,f41 ref]5ce to "w1 #bf ,hogs1 susceptibility to loco disease1 #ab ,holmes1 ,e4 ,m41 ref]5ce to "w1 #ce ,hornb]g]1 ,r41 ref]5ce to "w1 #ec ,horses1 autopsies aft] b>ium poison+1 #gc loco poison+1 #ah1 #bf b>ium poison+1 #gc disease caus$ by fe$+ on ,d>l+ pea 7,swa9sona galegifolia71 #af loco-plant exp]im5ts1 #cc loco poison+1 notes1 #af1 #ai1 #bj1 #bf loco$1 symptoms1 #ac susceptibility to loco disease1 #ab ,h\gh1 ,w41 ref]5ce to "w1 #ce ,h[>d1 ,c4 ,d41 ref]5ce to "w1 #gc ,hugo1 ,colo41 soils1 analysis = traces ( b>ium1 #eg ,hunt1 ,reid1 /udy ( & exp]im5ts ) loco plants1 #cc-cd ,hurd1 ,h4 ,m41 ref]5ce to "w1 #ce ,husemann1 ,t41 ref]5ce to "w1 #fb ,hydrocyanic acid1 pres5ce 9 loco plants1 sugge/ion1 #bi ,indigo disease1 simil>ity to loco disease1 #af-ag ,+]soll1 /udy ( loco disease1 #cj ,injections1 subcutane\s1 exp]im5ts ) b>ium salts1 #fb1 #gc1 #gd loco extracts1 #dc ,insanity1 treatm5t1 use ( ,a/ragalus mollissimus1 #ce ,insect ,life1 ref]5ce to "w1 #ca ,intoxication caus$ by loco plants1 #ac1 #af1 #ba1 #bb ,jaks*1 ,j4 v41 ref]5ces to "w1 #ea1 #fb ,janvi]1 ref]5ce to "w1 #aa ,kabitz1 ,h41 ref]5ce to "w1 #gd ,kansas1 loss ( /ock f loco disease 9 #ahhc1 #i ,kellogg1 ,a41 ref]5ce to "w1 #ai ,kelsey1 ,f4 ,d41 ref]5ce to "w1 #aj ,k5n$y1 ,h41 ref]5ce to "w1 #fc ,k5n$y1 ,j41 exp]im5ts ) loco-we$ extracts1 #bc1 #bf ,k+sley1 ,b4 ,f41 ref]5ce to "w1 #ab ,kissn]1 ,g41 ref]5ce to "w1 #fa ,kitt5s1 loco-plant exp]im5ts1 & autopsies1 #bd-bh ,see also ,cats4 ,kleu*1 ,j4 ,p41 ref]5ce to "w1 #ai ,knop1 ,w41 ref]5ce to "w1 #ec ,kn[les1 ,m4 ,e41 ref]5ces to "w1 #ac1 #ad ,kob]t1 ,r41 ref]5ces to "w1 #cc1 #ed ,lab&1 ,l41 ref]5ce to "w1 #ea ,laboratory exp]im5ts ) loco plants1 #cf-eg ,lag>de1 ,p41 ref]5ce to "w1 #fd ,lambs1 exp]im5ts 9 fe$+ loco plants1 symptoms & autopsies1 #ca1 #de1 #df ,lane1 ,c4 ,b41 ref]5ce to "w1 #gd ,lan?anum *lorid1 exp]im5ts on rabbits1 #ej ,la?yrism1 symptoms1 resemblance to loco poison+1 #ae ,leucocr9um montanum1 suppos$ cause ( loco disease1 #aj ,lew91 ,l41 ref]5ces to "w1 #fe1 #gb ,lewis1 ,doctor1 exp]im5ts ) loco plants on rabbits1 #cj ,l9ossi]1 ,g41 ref]5ce to "w1 #gd ,lisfranc1 ref]5ce to "w1 #fd ,lloyd1 ,j4 ,w41 /udy ( loco poison1 #ca1 #cb ,loco-acid1 body suppos$ to be 9 loco plants1 #cj disease1 attribut$ to hairs on plants1 #bb1 #bh worms1 #ca1 #cd exp]im5ts1 ,colorado1 results1 #e symptoms1 descriptions1 #aa1 #ab-af1 #ag1 #bd1 #bf1 #bh1 #bi1 #cc1 #cf-dd eat+ habit1 description1 #ad1 #ae intoxication1 #ac1 #af1 #ba1 #bb inve/igations f a ph>macological /&po9t1 hi/orical sket*1 #ai-cd plants1 a% det]m9ations1 #ed-ee a%$1 aque\s extracts1 effect1 #dh-eb b>ium det]m9ations1 #ee-eg eat5 ) l>ge am\nts ( o!r food presumably n dang]\s1 #ga effects on human be+s1 #ae1 #bj1 #bb1 #ce extracts1 dige/ion ) peps9 & pancreat91 exp]im5ts1 #ff-fh extracts1 v>iations 9 toxicity1 #ff-ga use 9 laboratory exp]im5ts1 v>y+ toxicity1 #cf-eb1 #ff-ga li/1 #aj poison1 v>y+ 9 c>nivor\s & h]bivor\s animals1 #bc ) season1 v>iety1 & orig91 #be1 #dh uses z food1 =age1 m$ic9e1 etc41 #ce )\t b>ium n poison\s1 #fh-ga ,see also ,loco we$s4 poison1 attempts to isolate ! active pr9ciple1 #dg poison+1 laboratory /udy1 results1 #e-f symptoms1 #aa1 #ab-af1 #ag1 #bd1 #bf1 #bh1 #bi1 #cc1 #cf-dd reproduction 9 rabbits1 #bi1 #cc1 #cf-dd1 #ge !oretical antidote1 #ga-gb ,loco$ animals1 cl9ical symptoms1 #ab-af pa?ological conditions z describ$ on ! range1 #ah-ai d]ivation ( t]m1 #i ,loco91 exp]im5ts by ,ru$i1 #cj ,loco-we$ disease1 geographical di/ribution1 #i family1 notes on use ( v>i\s memb]s1 #ce ,see also ,loco plants4 ,lopes1 ,a41 ref]5ce to "w1 #fd ,lotus am]icanus1 suppos$ cause ( loco disease1 #aj ,ldek+1 ,c41 ref]5ce to "w1 #gb ,lutt]kor?1 ,h41 ref]5ce to "w1 #ec ,mc,cullaugh1 ,f4 ,a41 ref]5ces to "w1 #ab1 #ac1 #ae1 #ai ,mc,eackran1 ,doctor1 loco-plant exp]im5ts ) horse1 #cc ,magnesium acetate1 exp]im5ts on rabbits1 #eb ,magnus1 ,r41 ref]5ce to "w1 #eh ,maid51 ,j4 ,h41 ref]5ce to "w1 #af ,mais*1 ,j4 ,m41 ref]5ces to "w1 #ba1 #ce ,malbec1 ,a41 ref]5ce to "w1 #eh ,malnutrition1 cause ( loco disease1 sugge/ion1 #bi1 #cd ,malva/rum cocc9eum1 suppos$ cause ( loco disease1 #aj ,man1 b>ium poison+1 #fb-fe loco poison+1 symptoms1 #ae ,manganese acetate1 exp]im5ts on rabbits1 #ea ,manitoba1 occurr5ce ( loco poison+1 #aj ,m>9e plants1 b>ium tak5 up f sea1 #ec ,m>%1 ,dr4 ,c4 ,dwight1 inve/igation & collection ( loco plants1 & ref]5ce to publi%$ pap]1 #cf1 #ge ,m>%all1 ,h4 ,t41 loco plant /udy1 ref]5ce to "w1 #ca1 #cd ,m>t91 ,c4 ,j41 description ( effects ( fe$+ ! ,d>l+ pea to %eep1 #af-ag ,mat!ws1 ,w41 ref]5ce to "w1 #ce ,mayo1 ,n4 ,s41 loco-plant /udies1 ref]5ces to "w1 #aa1 #ac1 #ah1 #cb1 #ga ,meat f loco$ cattle h>mless1 #fe ,m$icago sativa4 ,see ,alfalfa4 ,m$ic9e1 use ( loco plants1 #ce ,meltz]1 ,s4 ,j41 ref]5ce to "w1 #eb ,mexico1 plants caus+ loco$ condition1 #aj1 #aa ,mickwitz1 ,l41 ref]5ce to "w1 #ei ,mill]1 ,c4 ,h41 ref]5ce to "w1 #ac ,mittel/a$t1 ,f41 ref]5ces to "w1 #fb1 #fe ,m(fat1 ,p41 /udy ( loco plants1 #bj ,mules1 susceptibility to loco disease1 #ab ,nagl]1 ,f41 ref]5ce to "w1 #gc ,nausea1 effect ( loco plants on man1 #ae1 #bj1 #bb ,nelson1 ,s4 ,b41 ref]5ce to "w1 #cc ,n5ta1 goat disease1 ,s\? ,africa1 #ag ,neumann1 ,j41 ref]5ce to "w1 #eh ,neuritis1 p]iph]al1 9 loco$ animals 9 ,au/ralia1 #ag ,new ,s\? ,wales1 ,agricultural ,gazette1 ref]5ces1 #af1 #ag ,night%ade spp41 suppos$ cause ( loco$ condition 9 ,mexico1 #aj ,nockolds1 ,c41 ref]5ces to "w1 #ab1 #ad ,no?nagel1 ,h41 ref]5ce to "w1 #fe ,noyes1 ,a4 ,a41 ref]5ce to "w1 #ec ,oatman1 ,h4 ,c41 exp]im5ts ) alfalfa extract1 #bh ,o',br9e1 loco-plant /udies & analyses & ref]5ces to "w1 #ac1 #ah1 #ai1 #bg1 #cb1 #cc1 #ed ,onsum1 ,j41 ref]5ce to "w1 #fa ,orange ,judd ,f>m]1 ref]5ce1 #fc ,orfila1 ref]5ce to "w1 #ei ,os][1 ref]5ce to "w1 #dh ,ott1 ,dr4 ,isaac1 exp]im5ts ) extract ( ,a/ragalus mollissimus1 results1 #bb ,oxytropis lamb]ti1 analyses1 #bj ,see also ,aragallus4 ,p>alysis1 result ( b>ium poison+ 9 man1 #fd ,p>asites1 loco plants1 sugge/$ cause ( loco disease1 #ca1 #cd ,p>k]1 ,w4 ,t41 ref]5ce to "w1 #ac ,p>kes1 ref]5ce to "w1 #gd ,pa?ological conditions 9 b>ium poison+1 #fe loco$ animals on ! range1 #ah-ai ,patt]son1 ,a4 ,h41 ref]5ce to "w1 #ab ,pauli1 ,w41 ref]5ce to "w1 #fe ,payne1 ,j4 ,e41 ref]5ce to "w1 #cd ,pelleti]1 ,d41 ref]5ces to "w1 #fb1 #gc ,pigs1 b>ium poison+1 #gd gu9ea4 ,see ,gu9ea pigs4 ,pilgrim1 ,c4 ,w41 ref]5ce to "w1 #aa ,pilliet1 ,a41 ref]5ce to "w1 #eh ,plants1 m>9e1 b>ium tak5 up f sea1 #ec ,plnius1 ,w41 ref]5ce to "w1 #da ,poison1 loco1 attempts to isolate ! active pr9ciple1 #dg prop]ties ( c]ta9 loco plants1 #ce ,poison+1 b>ium1 exp]im5tal1 pa?ological lesions1 #fe horses1 %eep1 & pigs1 #gc1 #gd man1 #fb-fe acute cases1 symptoms1 results1 #fd possibility ( production f use ( food1 #fd ,poison+1 loco1 !oretical antidote1 #ga-gb symptoms1 #aa1 #ab-af1 #ag1 #bd1 #bf1 #bi1 #cc1 #cf-dd reproduction 9 rabbits1 #bi1 #cc1 #cf-dd1 #ge ,por*]1 ,f4 ,p41 ref]5ce to "w1 #ce ,po/-mortems4 ,see ,autopsies4 ,pott1 ,e41 ref]5ce to "w1 #ce ,p[]1 ,f4 ,b41 exp]im5ts ) loco plants1 #bf-bh ,pregnancy1 animals 91 exp]im5ts 9 fe$+ b>ium salts1 #fb loco plants1 #da1 #db ,prescott1 ,a4 ,b41 /udy ( ,aragallus lamb]ti1 #bj ,rabbits1 autopsies aft] b>ium poison+1 #eg-fa1 #fg loco poison+1 #cj1 #cd1 #cf-dc b>ium salts1 fe$+ exp]im5ts1 #eg-fb *emicals 9 aque\s solutions1 fe$+ exp]im5ts1 #ej-eb loco plants1 a% extracts1 fe$+ exp]im5ts1 #dh-di1 #ff-ga fe$+ exp]im5ts1 #bb1 #bd1 #bi1 #cj1 #cc1 #cd 9 laboratory1 #cf-dd1 #dh-di1 #ff-ga reproduction ( symptoms ( loco poison+1 #bi1 #cc1 #cf-dd1 #ge ,rabies1 treatm5t1 use ( ,a/ragalus k5trophyta1 #ce ,rabuteau1 ref]5ce to "w1 #ei ,ragwort1 poison\s effects1 ,canada1 #ag ,ram1 b>ium poison+1 autopsy1 #gd ,ration1 daily1 gre5 food = cattle1 toxic effects ( loco plants1 #gd ,rats1 fe$+ exp]im5ts ) b>ium c>bonate1 #ga ,rattle-box4 ,see ,crotal>ia sagittalis4 ,rattlewe$ disease4 ,see ,loco disease4 ,rei*>dt1 ,e41 ref]5ce to "w1 #fd ,re9cke1 ,j4 ,j41 ref]5ce to "w1 #ei ,res9s f loco plants1 exp]im5ts1 #bf ,reynolds1 ,m4 ,h41 inve/igations ) b>ium1 #fe ,rhamnus lanceolata1 suppos$ cause ( loco disease1 #aj ,rocky ,m\nta9s1 high p]c5tage ( b>ium 9 rocks1 #ed ,roscoe1 ,h4 ,e41 ref]5ce to "w1 #ec ,ros5?al1 ,d4 ,a41 ref]5ce to "w1 #ce ,rossba*1 ,m4 ,j41 ref]5ce to "w1 #fe ,ro?rock1 description ( loco plants1 effects on animals1 #bj1 #ba ,ru$i1 ,c>l1 exp]im5ts ) loco plants & ref]5ces to "w1 #ad1 #ai1 #bi-cj ,sages said to cause loco disease1 #aa ,salivation1 result ( loco poison1 #ab use ( b>ium on human be+s1 #fc ,salt licks suppos$ to cause loco disease1 #aa prev5tion ( poison\s effects ( ,d>l+ pea1 #ag ,santi1 ,l41 ref]5ces to "w1 #ei1 #gb ,sayre1 ,l4 ,e41 inve/igations & exp]im5ts & ref]5ces to "w1 #aj1 #aa1 #ad1 #ah1 #ai1 #bb1 #bc1 #be1 #bh1 #bi1 #cj1 #ca1 #cd1 #dh ,s*$el1 ,h41 ref]5ce to "w1 #fe ,s*eibl]1 ,c41 ref]5ce to "w1 #fd ,s*irm]1 ref]5ce to "w1 #gd ,s*orlemm]1 ,c41 ref]5ce to "w1 #ec ,s*u*>dt1 ,b41 description ( symptoms ( loco$ animals1 simil> to la?yrism1 #ae ,s*ulz1 ,h41 ref]5ce to "w1 #fc ,s*w>tzkopff1 ,o41 ref]5ces to "w1 #ab1 #ac ,s*wilgu1 ,c4 ,j4 ,a41 ref]5ce to "w1 #fc ,sci5ce1 ref]5ces to pap]s on loco plants1 #aa1 #ca ,scr(ula1 treatm5t1 use ( b>ium1 #fb ,s5ecio jacoboea1 poison\s effects1 #ag ,se/9i1 ,f41 te/s = b]yllium1 #ej ,%eep1 autopsies aft] b>ium poison+1 #gd loco poison+1 #ah1 #cj1 #cc1 #de disease caus$ by fe$+ on ,d>l+ pea1 #af-ag loco-plant fe$+ exp]im5ts1 #cj1 #dd-df poison+1 notes1 #bj1 #bb1 #cj1 #cc1 #cd loco$1 symptoms1 #ad-ae susceptibility to loco disease1 #ab ,smi?1 ,j4 ,g41 ref]5ce to "w1 #ce ,sn[1 ,f4 ,h41 ref]5ce to "w1 #ca ,soils1 analysis1 ,hugo1 ,colo41 = traces ( b>ium1 #eg ,sophora s]icea1 suppos$ cause ( loco disease1 #aj ,sp9e diseases1 treatm5t1 use ( b>ium1 #fc ,spr5gel1 ,c41 ref]5ce to "w1 #ec ,/agg]s1 grass1 ,texas loco disease1 symptoms1 description1 #aa ,/alk]1 ,m41 description ( symptoms ( loco$ animals & ref]5ces to "w1 #aj1 #aa1 #ad1 #ae1 #af1 #ah1 #ba1 #bf1 #fd ,/eele1 ,c4 ,d41 ref]5ce to "w1 #ca ,/]n1 ,e41 ref]5ce to "w1 #fd ,/iet5ro?1 ref]5ce to "w1 #gc ,/ipa vaseyi1 suppos$ cause ( loco disease1 #aj ,/ock1 losses f loco diseases1 #i1 #cd poison+ by b>ium 9 br9e1 #gc ,/ockman1 ,doctor1 exp]im5ts ) extracts ( ,a/ragalus mollissimus1 #bb ,/or]1 ,f4 ,h41 ref]5ce to "w1 #gb ,/orke1 ,b4 ,f41 ref]5ces to "w1 #ai1 #be ,/rontium acetate1 exp]im5ts on rabbits1 #eb ,subcutane\s injections4 ,see ,injections4 ,sullivan1 ,dr4 ,e4 ,c41 det]m9ation ( b>ium 9 ,aragallus lamb]ti1 #ed ,sulphates antidotal to b>ium1 sugge/ions1 #ga-gb1 #ge ,suzuki1 ,u41 ref]5ce to "w1 #ec ,swa91 ,r4 ,e41 ref]5ce to "w1 #di ,swa9sona galegifolia4 ,see ,d>l+ pea4 spp41 effects on %eep & horses1 simil> to loco poison+1 #af-ag ,syphilis1 treatm5t1 use ( ,a/ragalus exscapus1 #ce ,ta5ia expansa4 ,see ,tapeworm4 ,taito1 ,f41 ref]5ce to "w1 #fd ,tallqui/1 ,t4 ,w41 ref]5ce to "w1 #ca ,tapeworm1 %eep1 sugge/$ cause ( loco disease1 #cj ,texas grass /agg]s1 loco disease1 symptoms1 description1 #aa ,?allium nitrate1 exp]im5ts on rabbits1 #ej ,?orium *lorid1 exp]im5ts on rabbits1 #ej ,?orpe1 ,t4 ,e41 ref]5ce to "w1 #eg ,tidy1 ,c4 ,m41 ref]5ce to "w1 #fa ,tirabos*t1 ,a41 ref]5ce to "w1 #fd ,titanium *lorid1 exp]im5ts on rabbits1 #ej ,tixi]1 ,l41 ref]5ce to "w1 #da ,torrey1 ,j41 ref]5ce to "w1 #ai ,toxicity1 v>iations 9 extracts ( loco plants1 #ff-ga ,turn]1 ,f41 ref]5ce to "w1 #ag ,ulc]s 9 /oma*1 #ah1 #bd1 #cg1 #da1 #dc1 #di1 #fi ,vasey1 ,george1 inve/igations & ref]5ces to "w1 #ab1 #ac1 #ad1 #ai1 #bj1 #ba ,wait1 ,c4 ,e41 ref]5ce to "w1 #ea ,wal%1 ,j41 ref]5ce to "w1 #fd ,watson1 ,s41 /udy ( ,aragallus lamb]ti1 #bj ,web]1 ,f4 ,r41 ref]5ce to "w1 #ei ,:eat1 b>ium pres5t1 #ec ,:eel]1 ,g4 ,m41 ref]5ces to "w1 #bj1 #ba ,wilcox1 ,e4 ,v41 ref]5ces to "w1 #aa1 #cc ,wilcox1 ,t4 ,e41 ref]5ce to "w1 #ac ,williams1 ,t4 ,a41 ref]5ce to "w1 #aj ,w9sl[1 ,k41 ref]5ce to "w1 #gc ,wohlwill1 ,f41 ref]5ce to "w1 #ea ,woll1 ,f4 ,w41 ref]5ce to "w1 #gd ,woolls1 ,w41 ref]5ce to "w1 #ag ,worms1 cause ( loco disease1 sugge/ion1 #cj1 #ca1 #cd ,yttrium *lorid1 exp]im5ts on rabbits1 #ea ,zirconium *lorid1 exp]im5ts on rabbits1 #ej-ea ,zygad5us elegans1 suppos$ cause ( loco disease1 #aj 99 99 99 99 99 ,,transcrib] ,,notes3 ,obvi\s typographical errors & punctuation has be5 correct$ )\t note4 ,alt]nate spell+s & mis-spell+s 9 ! orig9al h be5 reta9$4 ,page #bf3 analag\s *ang$ to analog\s 7"s plant analog\s to74 ,footnote #if3 ,crotall>ia *ang$ to ,crotal>ia 7,poison\s ,effects ( ,crotal>ia74 ,page #eb3 ,rubidum *ang$ to ,rubidium 7,rubidium *lorid c4 p474 ,page #gf3 is *ang$ to x 7s t x is n74